101. Exercise-Induced Cardiac Fatigue after a 45-Minute Bout of High-Intensity Running Exercise Is Not Altered under Hypoxia
- Author
-
John D. Somauroo, David L. Oxborough, Alessandro Fornasiero, Christopher Johnson, Dick H. J. Thijssen, Keith P. George, Arie P.J. van Dijk, Guilherme Fleury Fina Speretta, Maria T. E. Hopman, Nicholas Sculthorpe, and Geert Kleinnibbelink
- Subjects
Adult ,Male ,Cardiac function curve ,medicine.medical_specialty ,Heart Ventricles ,Ventricular Dysfunction, Right ,Vascular damage Radboud Institute for Health Sciences [Radboudumc 16] ,Speckle tracking echocardiography ,030204 cardiovascular system & hematology ,Running ,030218 nuclear medicine & medical imaging ,RC1200 ,Young Adult ,03 medical and health sciences ,0302 clinical medicine ,Afterload ,Internal medicine ,Fraction of inspired oxygen ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Hypoxia ,Exercise ,Fatigue ,Ejection fraction ,business.industry ,High intensity ,Metabolic Disorders Radboud Institute for Health Sciences [Radboudumc 6] ,Stroke Volume ,Hypoxia (medical) ,medicine.anatomical_structure ,Ventricle ,Ventricular Function, Right ,Cardiology ,medicine.symptom ,Cardiology and Cardiovascular Medicine ,business - Abstract
Contains fulltext : 235286.pdf (Publisher’s version ) (Open Access) BACKGROUND: Acute exercise promotes transient exercise-induced cardiac fatigue, which affects the right ventricle and to a lesser extent the left ventricle. Hypoxic exposure induces an additional increase in right ventricular (RV) afterload. Therefore, exercise in hypoxia may differently affect both ventricles. The aim of this study was to investigate the acute effects of a bout of high-intensity exercise under hypoxia versus normoxia in healthy individuals on right- and left-sided cardiac function and mechanics. METHODS: Twenty-one healthy individuals (mean age, 22.2 ± 0.6 years; 14 men) performed 45-min high-intensity running exercise under hypoxia (fraction of inspired oxygen 14.5%) and normoxia (fraction of inspired oxygen 20.9%) in a randomized order. Pre- and post-exercise echocardiography, at rest and during low-to-moderate intensity recumbent exercise ("stress"), was performed to assess RV and left ventricular (LV) cardiac function and mechanics. RV structure, function, and mechanics were assessed using conventional two-dimensional, Doppler, tissue Doppler, speckle-tracking echocardiographic, and novel strain-area loops. RESULTS: Indices of RV systolic function (RV fractional area change, Tricuspid annular plane systolic excursion, RV s', and RV free wall strain) and LV function (LV ejection fraction and LV global longitudinal strain) were significantly reduced after high-intensity running exercise (P .05). CONCLUSIONS: There was no impact of hypoxia on the magnitude of exercise-induced cardiac fatigue in the right and left ventricles after a 45-min bout of high-intensity exercise. This finding suggests that any potential increase in loading conditions does not automatically exacerbate exercise-induced cardiac fatigue in this setting.
- Published
- 2021