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531 results on '"Di Martino, S."'

103. Insight e resistenza nei pazienti ossessivi

Author

CATAPANO, Francesco, SPERANDEO R., DI MARTINO S., BARTOLI L., MAJ M., Catapano, Francesco, Sperandeo, R., DI MARTINO, S., Bartoli, L., and Maj, M.

Published
1996

108. Web Accessibility

Author

Costagliola, Gennaro, DI MARTINO, S, Ferrucci, Filomena, and Gravino, Carmine

Published
2006

112. Visual input effect on EMG activity of masticatory and postural muscles in healthy and in myopic children

Author

Monaco, A., Cattaneo, R., Spadaro, A., Giannoni, M., Di Martino, S., and Roberto Gatto

Subjects
Adolescent, Electromyography, Neck Muscles, Case-Control Studies, Masticatory Muscles, Myopia, Visual Perception, Humans, Centric Relation, Child, Proprioception
Abstract

The purpose of this study was to evaluate the activity of Anterior Temporal, Masseter, Sternocleidomastoid and Anterior Digastric muscles in response to changes in visual input in subjects with defective vision by means surface electromyography.A total of 20 children, aged between 7 and 13 years, were evaluated. In the study group 10 children with myopic defects were enlisted, selected among patients afferent to the paediatric dentistry clinic. Ten subjects with normal vision, the control group, were chosen through the Pair Matching procedures, so that each myopic child had a matching age case control. Both study group and control group patients maintained mandible at rest with teeth apart and were submitted to a 15-sec electromyography (EMG) recording with closed eyes followed by a 15-sec EMG recording with open eyes.The Root Mean Square (RMS) values were elaborated to obtain means and standard deviation. Statistical analysis was undertaken using the Student's T-test for independent samples. Analysis of the results demonstrated a marked difference in tonic activity of temporal anterior muscles at open eyes between the myopic and the normal groups.The findings suggest that in the evaluation of masticatory muscles tenderness, such as episodic tension type headaches, attention should be paid to vision defects.

Published
2006

113. A FUZZY-BASED DISTANCE TO IMPROVE EMPIRICAL METHODS FOR MENU CLUSTERING

Author

CRISTINA COPPOLA, Costagliola, G., Di Martino, S., Ferrucci, F., Pacelli, T., Yannis Manolopoulos, Joaquim Filipe, Panos Constantopoulos, José Cordeiro, Coppola, Cristina, Costagliola, Gennaro, Di Martino, Sergio, Ferrucci, Filomena, and Pacelli, Tiziana

Subjects
Human-Computer Interaction, Artificial Intelligence, Design methodology, Human factor, Menu design, Information System, Software
Abstract

An effective menu organization is fundamental to obtain usable applications. A common practice to achieve this is to adopt empirical methods in the menu design phase, by requesting a number of intended final users to provide their ideal tasks arrangements. However, to improve the effectiveness of this approach, it is necessary to filter results, by identifying and discarding data coming from subjects whose mental models are too weak on the considered domain. To this aim, in the paper, we propose a formal tool suited to support menu designers, which is based on a fuzzy-based distance we defined. This measure can be easily calculated on the empirical datasets, thanks to a specifically conceived supporting application we developed. As a result, by exploiting the proposed solution, menu designers can rely on a formal tool to evaluate significance of empirical data, thus leading towards more effective menu clustering.

Published
2006

117. Correlation between individual inflammation genetic profile and platelet rich plasma efficacy in hair follicle regeneration: a pilot study reveals prognostic value of IL-1a polymorphism.

Author

ROSSANO, F., DI MARTINO, S., IODICE, L., DI PAOLO, M., MISSO, S., TOMEO, R., MARINI, A. M., BRUGNONE, R., MARLINO, S., SANTORELLI, A., and DI FRANCIA, R.

Abstract

OBJECTIVE: Hair loss generates severe psychosocial implications. To date, exploring the prognostic factors of possible clinical benefit of autologous blood concentrate platelet rich plasma (PRP) was failed. The aim of our pilot study was to explore the correlation between the individual inflammation genetic profile and PRP efficacy in the treatment of hair follicle regeneration. PATIENTS AND METHODS: 41 volunteers (25 men, 16 women) took part in this retrospective study. All the patients were scheduled for 4 sessions of PRP application with intervals of 40-60 days. All the patients were checked up at 6 weekly intervals for 6 months and, then, at the end of the first year. A panel of 5 polymorphisms on 4 genes (IL-1a, IL-1b, IL-6, and IL-10) implicated in the individual genetic inflammation profile were performed. RESULTS: A significant increase rate in hair density was noticed after the third month of treatment in 32/41 (78%) of the subjects. We found an interesting association between the pro-inflammatory cytokine IL-1a polymorphism C>A (rs17561) and responders to PRP treatment. The cases carrying C/C genotype (coding for Ser114) were 21 (66%) in responders and only 2 (22%) in non-responders (p<0.05). In addition, about IL-1a, the frequency of G/G genotype in responder patients was over two times lower in responder (31%) than in non-responder patients (78%). CONCLUSIONS: Our pilot study demonstrated a correlation between the individual genetic inflammatory profile and the efficacy of the PRP treatment in males. On the contrary, in females, it showed a negative correlation. IL-1a could be used as a prognostic value for PRP efficacy. Also, these results provide preliminary evidence that may encourage the design of controlled clinical trials to properly test this modus operandi on a large number of subjects. [ABSTRACT FROM AUTHOR]

Published
2017

139. Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo

Author

Signore, M, Pelacchi, F, Di Martino, Susanna, Runci, D, Biffoni, M, Giannetti, Stefano, Morgante, Liliana, De Majo, M, Petricoin, Ef, Stancato, L, Larocca, Luigi Maria, De Maria Marchiano, Ruggero, Pallini, Roberto, Ricci-Vitiani, L., di Martino S, Giannetti S (ORCID:0000-0002-9456-8865), Morgante L, Larocca LM (ORCID:0000-0003-1739-4758), De Maria Marchiano R (ORCID:0000-0003-2255-0583), Pallini R (ORCID:0000-0002-4611-8827), Signore, M, Pelacchi, F, Di Martino, Susanna, Runci, D, Biffoni, M, Giannetti, Stefano, Morgante, Liliana, De Majo, M, Petricoin, Ef, Stancato, L, Larocca, Luigi Maria, De Maria Marchiano, Ruggero, Pallini, Roberto, Ricci-Vitiani, L., di Martino S, Giannetti S (ORCID:0000-0002-9456-8865), Morgante L, Larocca LM (ORCID:0000-0003-1739-4758), De Maria Marchiano R (ORCID:0000-0003-2255-0583), and Pallini R (ORCID:0000-0002-4611-8827)

Abstract

Glioblastoma (GBM) is the most common and deadly adult brain tumor. Despite aggressive surgery, radiation, and chemotherapy, the life expectancy of patients diagnosed with GBM is ∼14 months. The extremely aggressive nature of GBM results from glioblastoma stem-like cells (GSCs) that sustain GBM growth, survive intensive chemotherapy, and give rise to tumor recurrence. There is accumulating evidence revealing that GSC resilience is because of concomitant activation of multiple survival pathways. In order to decode the signal transduction networks responsible for the malignant properties of GSCs, we analyzed a collection of GSC lines using a dual, but complementary, experimental approach, that is, reverse-phase protein microarrays (RPPMs) and kinase inhibitor library screening. We treated GSCs in vitro with clinically relevant concentrations of temozolomide (TMZ) and performed RPPM to detect changes in phosphorylation patterns that could be associated with resistance. In addition, we screened GSCs in vitro with a library of protein and lipid kinase inhibitors to identify specific targets involved in GSC survival and proliferation. We show that GSCs are relatively insensitive to TMZ treatment in terms of pathway activation and, although displaying heterogeneous individual phospho-proteomic profiles, most GSCs are resistant to specific inhibition of the major signaling pathways involved in cell survival and proliferation. However, simultaneous multipathway inhibition by the staurosporin derivative UCN-01 results in remarkable inhibition of GSC growth in vitro. The activity of UCN-01 on GSCs was confirmed in two in vivo models of GBM growth. Finally, we used RPPM to study the molecular and functional effects of UCN-01 and demonstrated that the sensitivity to UCN-01 correlates with activation of survival signals mediated by PDK1 and the DNA damage response initiated by CHK1. Taken together, our results suggest that a combined inhibition of PDK1 and CHK1 represents a poten

Published
2014

140. Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo

Author

Signore, M., Pelacchi, F., Di Martino, Susanna, Runci, D., Biffoni, M., Giannetti, Stefano, Morgante, Liliana, De Majo, M., Petricoin, E. F., Stancato, L., Larocca, Luigi Maria, De Maria Marchiano, Ruggero, Pallini, Roberto, Ricci-Vitiani, L., Di Martino, S., Giannetti, S. (ORCID:0000-0002-9456-8865), Morgante, L., Larocca, L. M. (ORCID:0000-0003-1739-4758), De Maria Marchiano, R. (ORCID:0000-0003-2255-0583), Pallini, R. (ORCID:0000-0002-4611-8827), Signore, M., Pelacchi, F., Di Martino, Susanna, Runci, D., Biffoni, M., Giannetti, Stefano, Morgante, Liliana, De Majo, M., Petricoin, E. F., Stancato, L., Larocca, Luigi Maria, De Maria Marchiano, Ruggero, Pallini, Roberto, Ricci-Vitiani, L., Di Martino, S., Giannetti, S. (ORCID:0000-0002-9456-8865), Morgante, L., Larocca, L. M. (ORCID:0000-0003-1739-4758), De Maria Marchiano, R. (ORCID:0000-0003-2255-0583), and Pallini, R. (ORCID:0000-0002-4611-8827)

Abstract

Glioblastoma (GBM) is the most common and deadly adult brain tumor. Despite aggressive surgery, radiation, and chemotherapy, the life expectancy of patients diagnosed with GBM is âˆ1⁄414 months. The extremely aggressive nature of GBM results from glioblastoma stem-like cells (GSCs) that sustain GBM growth, survive intensive chemotherapy, and give rise to tumor recurrence. There is accumulating evidence revealing that GSC resilience is because of concomitant activation of multiple survival pathways. In order to decode the signal transduction networks responsible for the malignant properties of GSCs, we analyzed a collection of GSC lines using a dual, but complementary, experimental approach, that is, reverse-phase protein microarrays (RPPMs) and kinase inhibitor library screening. We treated GSCs in vitro with clinically relevant concentrations of temozolomide (TMZ) and performed RPPM to detect changes in phosphorylation patterns that could be associated with resistance. In addition, we screened GSCs in vitro with a library of protein and lipid kinase inhibitors to identify specific targets involved in GSC survival and proliferation. We show that GSCs are relatively insensitive to TMZ treatment in terms of pathway activation and, although displaying heterogeneous individual phospho-proteomic profiles, most GSCs are resistant to specific inhibition of the major signaling pathways involved in cell survival and proliferation. However, simultaneous multipathway inhibition by the staurosporin derivative UCN-01 results in remarkable inhibition of GSC growth in vitro. The activity of UCN-01 on GSCs was confirmed in two in vivo models of GBM growth. Finally, we used RPPM to study the molecular and functional effects of UCN-01 and demonstrated that the sensitivity to UCN-01 correlates with activation of survival signals mediated by PDK1 and the DNA damage response initiated by CHK1. Taken together, our results suggest that a combined inhibition of PDK1 and CHK1 represents a

Published
2014

145. Combined PDK1 and CHK1 inhibition is required to kill glioblastoma stem-like cells in vitro and in vivo

Author

Signore, M, primary, Pelacchi, F, additional, di Martino, S, additional, Runci, D, additional, Biffoni, M, additional, Giannetti, S, additional, Morgante, L, additional, De Majo, M, additional, Petricoin, E F, additional, Stancato, L, additional, Larocca, L M, additional, De Maria, R, additional, Pallini, R, additional, and Ricci-Vitiani, L, additional

Published
2014
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