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101. Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in Psoriasis

Author

Goyal, Aditya, primary, Dey, Amit K., additional, Chaturvedi, Abhishek, additional, Elnabawi, Youssef A., additional, Aberra, Tsion M., additional, Chung, Jonathan H., additional, Belur, Agastya D., additional, Groenendyk, Jacob W., additional, Lerman, Joseph B., additional, Rivers, Joshua P., additional, Rodante, Justin A., additional, Harrington, Charlotte L., additional, Varghese, Nevin J., additional, Sanda, Gregory E., additional, Baumer, Yvonne, additional, Sorokin, Alexander V., additional, Teague, Heather L., additional, Genovese, Leonard D., additional, Natarajan, Balaji, additional, Joshi, Aditya A., additional, Playford, Martin P., additional, Bluemke, David A., additional, Chen, Marcus Y., additional, Alavi, Abass, additional, Pitman, Roger K., additional, Powell-Wiley, Tiffany M., additional, Tawakol, Ahmed, additional, Gelfand, Joel M., additional, and Mehta, Nehal N., additional

Published
2020
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102. Association Between Soluble Lectinlike Oxidized Low-Density Lipoprotein Receptor-1 and Coronary Artery Disease in Psoriasis

Author

Dey, Amit K., primary, Gaddipati, Ranjitha, additional, Elnabawi, Youssef A., additional, Ongstad, Emily, additional, Goyal, Aditya, additional, Chung, Jonathan H., additional, Teague, Heather L., additional, Rodante, Justin A., additional, Sajja, Aparna A., additional, Sorokin, Alexander V., additional, Lateef, Sundus S., additional, Aksentijevich, Milena, additional, Choi, Harry, additional, Reddy, Aarthi S., additional, Varghese, Nevin J., additional, Groenendyk, Jacob, additional, Belur, Agastya D., additional, Genovese, Leonard, additional, Rivers, Joshua P., additional, Lerman, Joseph, additional, Kabbany, Mohammad Tarek, additional, Harrington, Charlotte, additional, Ortiz, Jenis, additional, Khalil, Noor, additional, Keel, Andrew, additional, Baumer, Yvonne, additional, Chen, Marcus Y., additional, Bluemke, David A., additional, Joshi, Aditya A., additional, Kaplan, Mariana J., additional, Remaley, Alan T., additional, Playford, Martin P., additional, Karathanasis, Sotirios K., additional, Gelfand, Joel M., additional, Gupta, Ruchi, additional, and Mehta, Nehal N., additional

Published
2020
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105. Neighborhood environment perceptions associate with depression levels and cardiovascular risk among middle-aged and older adults: Data from the Washington, DC cardiovascular health and needs assessment.

Author

Andrews, Marcus R., Ceasar, Joniqua, Tamura, Kosuke, Langerman, Steven D., Mitchell, Valerie M., Collins, Billy S., Baumer, Yvonne, Gutierrez Huerta, Cristhian A., Dey, Amit K., Playford, Martin P., Mehta, Nehal N., and Powell-Wiley, Tiffany M.

Subjects
CARDIOVASCULAR diseases risk factors, BIOMARKERS, WELL-being, SOCIAL support, REGRESSION analysis, CARDIOVASCULAR diseases, SOCIAL context, SOCIOECONOMIC factors, MENTAL depression, FACTOR analysis, DESCRIPTIVE statistics, RESIDENTIAL patterns, NEEDS assessment, MIDDLE age, OLD age
Abstract

Little is understood about associations between neighborhood characteristics and depression, a cardiovascular disease (CVD) risk factor, in diverse populations. We examined relationships between perceived/objective neighborhood characteristics, depression, and CVD markers within the Washington, DC CV Health/Needs Assessment, an evaluation among predominantly African-American (AA) adults in resource-limited DC communities. Factor analysis of overall neighborhood environment perception (NEP) identified three NEP sub-scores:1) violence; 2) physical/social environment; 3) social cohesion (higher score = more favorable perception). Objective neighborhood characteristics were measured by geospatially-derived scores of walkability, transportation, and crime. Depression was defined by the revised Center for Epidemiologic Studies Depression Scale (CESD-R). We used linear-regression modeling to examine neighborhood measures and CESD-R associations. To investigate a subsequent connection with CVD risk, we examined relationships between CESD-R and CVD-associated cytokines in a population subset. Participants (N = 99; mean age = 59.06; 99% AA) had a mean CESD-R score = 5.8(SD = 8.88). In adjusted models, CESD-R scores decreased by 0.20 units (p = 0.01) for every overall NEP unit-increase. Perceived physical/social environment (β = −0.34, p = 0.04) and social cohesion (β = −0.82, p = 0.01) were related to CESD-R while perceived violence was not (β = −0.28, p = 0.1). Of objective neighborhood environment measures (i.e. walk, transit, bike, personal crime, and property crime scores), only property crime score was associated with depression (β = 4.99, p < 0.03). In population subset (n = 42), higher CESD-R associated with higher IL-1β (β = 21.25, p < 0.01) and IL-18 (β = 0.006, p = 0.01). Favorable neighborhood perceptions are related to lower depressive symptoms in a predominantly AA cohort from Washington, DC resource-limited communities. Neighborhood perceptions appear to be strongly associated with depressive symptoms compared to objective characteristics. Increasing CESD-R scores were related to higher pro-inflammatory markers. Improving neighborhood perceptions may be beneficial to psychological well-being and CV health for urban minority residents. [ABSTRACT FROM AUTHOR]

Published
2021
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107. WSO895709 Supplemental Material - Supplemental material for Contemporary utilization patterns and outcomes of thrombolytic administration for ischemic stroke among patients with cancer

Author

Owusu-Guha, Jocelyn, Avirup Guha, P Elliott Miller, Sumeet Pawar, Dey, Amit K, Ahmad, Tariq, Attar, Hatim, Awan, Farrukh T, Mitchell, Darrion, Nihar R Desai, and Addison, Daniel

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, WSO895709 Supplemental Material for Contemporary utilization patterns and outcomes of thrombolytic administration for ischemic stroke among patients with cancer by Jocelyn Owusu-Guha, Avirup Guha, P Elliott Miller, Sumeet Pawar, Amit K Dey, Tariq Ahmad, Hatim Attar, Farrukh T Awan, Darrion Mitchell, Nihar R Desai and Daniel Addison in International Journal of Stroke

Published
2019
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108. Chronic Stress-Related Neural Activity Associates With Subclinical Cardiovascular Disease in Psoriasis: A Prospective Cohort Study

Author

Goyal, Aditya, Dey, Amit K., Chaturvedi, Abhishek, Elnabawi, Youssef A., Aberra, Tsion M., Chung, Jonathan H., Belur, Agastya D., Groenendyk, Jacob W., Lerman, Joseph B., Rivers, Joshua P., Rodante, Justin A., Harrington, Charlotte L., Varghese, Nevin J., Sanda, Gregory E., Baumer, Yvonne, Sorokin, Alexander V., Teague, Heather L., Genovese, Leonard D., Natarajan, Balaji, Joshi, Aditya A., Playford, Martin P., Bluemke, David A., Chen, Marcus Y., Alavi, Abass, Pitman, Roger K., Powell-Wiley, Tiffany M., Tawakol, Ahmed, Gelfand, Joel M., and Mehta, Nehal N.

Subjects
Adult, Male, Single Photon Emission Computed Tomography Computed Tomography, Computed Tomography Angiography, Hematopoietic System, Anti-Inflammatory Agents, Comorbidity, Coronary Angiography, Article, Fluorodeoxyglucose F18, Predictive Value of Tests, Risk Factors, Multidetector Computed Tomography, Humans, Psoriasis, Prospective Studies, Aged, Middle Aged, Amygdala, United States, Cross-Sectional Studies, Treatment Outcome, Cardiovascular Diseases, Case-Control Studies, Asymptomatic Diseases, Chronic Disease, Female, Radiopharmaceuticals, Stress, Psychological
Abstract

This study hypothesized that there is an association between chronic stress (as indexed by resting amygdalar activity [AmygA]), hematopoietic system activity (HMPA), and subclinical cardiovascular indexes (aortic vascular inflammation [VI] and noncalcified coronary plaque burden [NCB]) in psoriasis (PSO). The study also hypothesized that treatment of PSO would improve these parameters.PSO is a stress-related chronic inflammatory condition that is associated with increased prevalence of subclinical cardiovascular disease (CVD). In individuals without PSO, stress has been linked to CVD through a serial biological pathway that involves the amygdala, hematopoietic tissues, and atherosclerotic plaques.A total of 164 consecutive patients with PSO and 47 healthy volunteers underwent 18-fluorodeoxyglucose positron emission tomography/computed tomography scans for assessment of AmygA, HMPA, and VI, as well as coronary computed tomography angiography scans for quantifying NCB. Furthermore, a consecutive subset of 30 patients with severe PSO (Psoriasis Area Severity Index Score10) were followed at 1 year to assess the relationship between skin disease improvement and AmygA, HMPA, VI, and NCB.The PSO cohort was middle-aged (mean age: 50 years), had low cardiovascular risk (Framingham risk score: median: 3) and had mild to moderate PSO activity (median Psoriasis Area Severity Index Score: 5.6). AmygA was higher in patients with PSO compared to volunteer participants. AmygA was associated with HMPA (bone marrow activity: β = 0.20, p = 0.01) and subclinical CVD (VI: β = 0.31, p 0.001; NCB: β = 0.27, p 0.001) The AmygA-CVD association was in part mediated by HMPA (VI: 20.9%, NCB: 36.7%). Following 1 year of PSO treatment in those with severe disease, improvement in skin disease was accompanied by a reduction in AmygA, bone marrow activity, and VI, with no progression of NCB.In PSO, a chronic inflammatory disease state, AmygA, which is a manifestation of chronic stress, substantially contributes to the risk of subclinical CVD. Additional studies that use psychometric measures of stress are required to explore therapeutic impact.

Published
2018

110. Association of Biologic Therapy With Coronary Inflammation in Patients With Psoriasis as Assessed by Perivascular Fat Attenuation Index

Author

Elnabawi, Youssef A., primary, Oikonomou, Evangelos K., additional, Dey, Amit K., additional, Mancio, Jennifer, additional, Rodante, Justin A., additional, Aksentijevich, Milena, additional, Choi, Harry, additional, Keel, Andrew, additional, Erb-Alvarez, Julie, additional, Teague, Heather L., additional, Joshi, Aditya A., additional, Playford, Martin P., additional, Lockshin, Benjamin, additional, Choi, Andrew D., additional, Gelfand, Joel M., additional, Chen, Marcus Y., additional, Bluemke, David A., additional, Shirodaria, Cheerag, additional, Antoniades, Charalambos, additional, and Mehta, Nehal N., additional

Published
2019
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111. Association of lipoprotein subfractions and glycoprotein acetylation with coronary plaque burden in SLE

Author

Purmalek, Monica M, primary, Carlucci, Philip M, additional, Dey, Amit K, additional, Sampson, Maureen, additional, Temesgen-Oyelakin, Yenealem, additional, Sakhardande, Simantini, additional, Lerman, Joseph B, additional, Fike, Alice, additional, Davis, Michael, additional, Chung, Jonathan H, additional, Salahuddin, Taufiq, additional, Manna, Zerai, additional, Gupta, Sarthak, additional, Chen, Marcus Y, additional, Hasni, Sarfaraz, additional, Mehta, Nehal N, additional, Remaley, Alan, additional, and Kaplan, Mariana J, additional

Published
2019
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117. Coronary artery plaque characteristics and treatment with biologic therapy in severe psoriasis: results from a prospective observational study

Author

Elnabawi, Youssef A, primary, Dey, Amit K, additional, Goyal, Aditya, additional, Groenendyk, Jacob W, additional, Chung, Jonathan H, additional, Belur, Agastya D, additional, Rodante, Justin, additional, Harrington, Charlotte L, additional, Teague, Heather L, additional, Baumer, Yvonne, additional, Keel, Andrew, additional, Playford, Martin P, additional, Sandfort, Veit, additional, Chen, Marcus Y, additional, Lockshin, Benjamin, additional, Gelfand, Joel M, additional, Bluemke, David A, additional, and Mehta, Nehal N, additional

Published
2019
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118. Association Between Oxidation-Modified Lipoproteins and Coronary Plaque in Psoriasis

Author

Sorokin, Alexander V., primary, Kotani, Kazuhiko, additional, Elnabawi, Youssef A., additional, Dey, Amit K., additional, Sajja, Aparna P., additional, Yamada, Shingo, additional, Ueda, Masashi, additional, Harrington, Charlotte L., additional, Baumer, Yvonne, additional, Rodante, Justin A., additional, Gelfand, Joel M., additional, Chen, Marcus Y., additional, Joshi, Aditya A., additional, Playford, Martin P., additional, Remaley, Alan T., additional, and Mehta, Nehal N., additional

Published
2018
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119. Abstract 16766: Increased Clinical and Financial Burden of Heart Failure Hospitalizations in Patients With Systemic Lupus Erythematosus: Insights From the National Inpatient Sample 2012-2014

Author

Joshi, Aditya A, primary, Sajja, Aparna P, additional, Dey, Amit K, additional, Lerman, Joseph B, additional, Aberra, Tsion M, additional, Patorroyo-Aponte, Maria M, additional, Murali, Srinivas, additional, Benza, Raymond L, additional, and Raina, Amresh, additional

Published
2018
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121. Contemporary utilization patterns and outcomes of thrombolytic administration for ischemic stroke among patients with cancer.

Author

Owusu-Guha, Jocelyn, Guha, Avirup, Miller, P Elliott, Pawar, Sumeet, Dey, Amit K, Ahmad, Tariq, Attar, Hatim, Awan, Farrukh T, Mitchell, Darrion, Desai, Nihar R, and Addison, Daniel

Subjects
STROKE patients, CANCER-related mortality, THROMBOLYTIC therapy, PROPENSITY score matching, CANCER patients
Abstract

Background: Thrombolytic therapy significantly improves outcomes among patients with acute ischemic stroke. While cancer outcomes have dramatically improved, the utilization, safety, and mortality outcomes of patients with cancer who receive thrombolytic therapy for acute ischemic stroke are unknown. Methods: Using a national database, we identified all hospitalizations for acute ischemic stroke requiring thrombolytic therapy between 2003 and 2015. Patients with contraindications to thrombolytic therapy were excluded. Following propensity score matching for comorbidity burden, trends in thrombolytic therapy use and its effect on in-hospital mortality, intracranial or all-cause bleeding, and the combined endpoint of mortality and all-cause bleeding, by presence/absence of cancer were evaluated. We also evaluated 30- and 90-day readmission rates post-thrombolytic therapy administration. Results: We identified 237,687 acute ischemic stroke hospitalizations requiring thrombolytic therapy, of which 26,328 (11%) had an underlying cancer. Over the study period, thrombolytic therapy use increased across all acute ischemic stroke admissions, irrespective of cancer presence (12.4/1000 in 2003 to 81.1/1000 in 2015, P < 0.0001). However, thrombolytic therapy utilization differed by cancer presence (4.8% cancer vs.·5.1% non-cancer, P = 0.001). There was no difference in intracranial bleeding (9.6% vs. 9.7%), all-cause bleeding (13.2% vs. 13.2%), or in-hospital mortality (7.6% vs. 7.2%). While there was no difference in 30-day readmission rates by cancer presence (24% vs. 29%, P = 0.40), at 90-days, cancer patients saw higher readmission rates (17.2% vs. 13.3%, P = 0.02). Conclusions: Contemporary thrombolytic therapy use for acute ischemic stroke has risen, irrespective of presence of cancer. Yet, patients with comorbid cancer appear to see lower rates of thrombolytic therapy use for acute ischemic stroke, despite no difference in the rate of intracranial bleeding or mortality after adjustment for comorbidities. [ABSTRACT FROM AUTHOR]

Published
2021
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122. Association Among Noncalcified Coronary Burden, Fractional Flow Reserve, and Myocardial Injury in Psoriasis.

Author

Wunan Zhou, Abdelrahman, Khaled M., Dey, Amit K., Reddy, Aarthi, Uceda, Domingo E., Lateef, Sundus S., Elnabawi, Youssef A., Anzenberg, Paula, Najafi, Mina Al, Rodante, Justin A., Keel, Andrew, Ortiz, Jenis, Teague, Heather L., Erb-Alvarez, Julie, Singh, Dolly, Joshi, Aditya A., Playford, Martin P., Chen, Marcus Y., Gelfand, Joel M., and Remaley, Alan T.

Published
2020
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123. Application of Non-invasive Imaging in Inflammatory Disease Conditions to Evaluate Subclinical Coronary Artery Disease.

Author

Choi, Harry, Uceda, Domingo E., Dey, Amit K., and Mehta, Nehal N.

Abstract

Purpose of Review: Traditional risk models, such as the Framingham risk score, fail to capture the increased cardiovascular disease risk seen in patients with chronic inflammatory diseases. This review will cover imaging modalities and their emerging applications in assessing subclinical cardiovascular disease for both research and clinical care in patients with chronic inflammatory diseases. Recent Findings: Multiple imaging modalities have been studied to assess for subclinical cardiovascular disease via functional/physiologic, inflammatory, and anatomic assessment in patients with chronic inflammatory diseases. Summary: The use of imaging to evaluate subclinical cardiovascular disease in patients with chronic inflammatory diseases has the potential to capture early sub-clinical atherosclerosis, to improve risk stratification of future cardiovascular events, and to guide effective disease management. [ABSTRACT FROM AUTHOR]

Published
2020
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124. Association of aortic vascular uptake of 18FDG by PET/CT and aortic wall thickness by MRI in psoriasis: a prospective observational study.

Author

Groenendyk, Jacob W., Shukla, Parag, Dey, Amit K., Elnabawi, Youssef A., Aksentijevich, Milena, Choi, Harry, Genovese, Leonard D., Harrington, Charlotte L., Natarajan, Balaji, Goyal, Aditya, Reddy, Aarthi S., Rodante, Justin, Kabbany, Mohammad Tarek, Sadek, Ahmed, Al Najafi, Mina, Playford, Martin P., Joshi, Aditya A., Ahlman, Mark A., Gelfand, Joel M., and Bluemke, David A.

Subjects
PSORIASIS, LONGITUDINAL method, WAIST-hip ratio, AUTORADIOGRAPHY, FLUORODEOXYGLUCOSE F18, CAROTID intima-media thickness, SCIENTIFIC observation
Abstract

Background: The contribution of inflammation to the incidence of cardiovascular disease (CVD) has been increasingly recognized in recent years. We investigated the relationship of aortic vascular uptake of 18F-FDG by PET/CT and aortic wall thickness (AWT) by MRI in psoriasis, a chronic inflammatory disease with increased incidence of CVD. One hundred sixty-five patients with plaque psoriasis participated in an ongoing longitudinal cohort study. Subclinical atherosclerosis was assessed as aortic uptake of 18F-FDG by PET/CT reported as target-to-background ratio (TBR) and AWT by MRI reported as maximal thickness. Results: Patients with psoriasis were middle aged, predominantly male, and had mild CV risk by traditional risk factors. Psoriasis severity as measured by PASI score was a notable determinant of AWT (ρ = 0.20, p = 0.01). Moreover, aortic vascular uptake of 18F-FDG associated with AWT by MRI at baseline in unadjusted analysis (β = 0.27 p = 0.001) and following adjustment for traditional cardiovascular risk factors, waist-to-hip ratio, and statin use (β = 0.21 p = 0.01). Finally, following 1 year of psoriasis treatment, a decrease in aortic vascular uptake of 18F-FDG was associated with a reduction in AWT in fully adjusted models (β = 0.33, p = 0.02). Conclusion: In conclusion, we demonstrate that psoriasis severity and aortic vascular uptake of 18F-FDG in the aorta were associated with AWT. Following treatment of psoriasis, a decrease in aortic vascular uptake of 18F-FDG was associated with a reduction in AWT at 1 year. These findings suggest that aortic vascular uptake of 18F-FDG is associated with early evidence of vascular disease assessed by aortic wall thickness. Prospective studies in larger populations including other inflammatory diseases are warranted. [ABSTRACT FROM AUTHOR]

Published
2019
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126. Association Between Aortic Vascular Inflammation and Coronary Artery Plaque Characteristics in Psoriasis

Author

Joshi, Aditya A., primary, Lerman, Joseph B., additional, Dey, Amit K., additional, Sajja, Aparna P., additional, Belur, Agastya D., additional, Elnabawi, Youssef A., additional, Rodante, Justin A., additional, Aberra, Tsion M., additional, Chung, Jonathan, additional, Salahuddin, Taufiq, additional, Natarajan, Balaji, additional, Dave, Jenny, additional, Goyal, Aditya, additional, Groenendyk, Jacob W., additional, Rivers, Joshua P., additional, Baumer, Yvonne, additional, Teague, Heather L., additional, Playford, Martin P., additional, Bluemke, David A., additional, Ahlman, Mark A., additional, Chen, Marcus Y., additional, Gelfand, Joel M., additional, and Mehta, Nehal N., additional

Published
2018
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127. CS-24 Association of lipoprotein subfractions and glycoprotein acetylation with coronary plaque burden in systemic lupus erythematosus

Author

Purmalek, Monica M, primary, Carlucci, Philip M, additional, Dey, Amit K, additional, Sampson, Maureen, additional, Temesgen-Oyelakin, Yenealem, additional, Sakhardande, Simantini, additional, Lerman, Joseph B, additional, Fike, Alice, additional, Davis, Michael, additional, Chung, Jonathan H, additional, Salahuddin, Taufiq, additional, Manna, Zerai, additional, Gupta, Sarthak, additional, Chen, Marcus Y, additional, Hasni, Sarfaraz, additional, Mehta, Nehal N, additional, Remaley, Alan T, additional, and Kaplan, Mariana J, additional

Published
2018
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129. Abstract 549: Improvement in Large Density HDL Particle Number by NMR is Associated with Reduction in Coronary Soft Plaque Burden by Coronary Computed Tomography Angiography in Psoriasis

Author

Elnabawi, Yousssef A, primary, Dey, Amit K, additional, Goyal, Aditya, additional, Groenendyk, Jacob W, additional, Genovese, Leonard D, additional, Belur, Agastya D, additional, Rodante, Justin A, additional, Chen, Marcus Y, additional, Bluemke, David A, additional, Remaley, Alan T, additional, Playford, Martin P, additional, and Mehta, Nehal N, additional

Published
2018
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130. Neutrophil subsets and their gene signature associate with vascular inflammation and coronary atherosclerosis in lupus

Author

Carlucci, Philip M., primary, Purmalek, Monica M., additional, Dey, Amit K., additional, Temesgen-Oyelakin, Yenealem, additional, Sakhardande, Simantini, additional, Joshi, Aditya A., additional, Lerman, Joseph B., additional, Fike, Alice, additional, Davis, Michael, additional, Chung, Jonathan H., additional, Playford, Martin P., additional, Naqi, Mohammad, additional, Mistry, Pragnesh, additional, Gutierrez-Cruz, Gustavo, additional, Dell’Orso, Stefania, additional, Naz, Faiza, additional, Salahuddin, Taufiq, additional, Natarajan, Balaji, additional, Manna, Zerai, additional, Tsai, Wanxia L., additional, Gupta, Sarthak, additional, Grayson, Peter, additional, Teague, Heather, additional, Chen, Marcus Y., additional, Sun, Hong-Wei, additional, Hasni, Sarfaraz, additional, Mehta, Nehal N., additional, and Kaplan, Mariana J., additional

Published
2018
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131. Abstract P049: Serum Uric Acid Levels Are Associated With Non-Calcified Coronary Plaque Independent of Traditional Cardiovascular Risk Factors in Patients With Psoriasis

Author

Elnabawi, Youssef A, primary, Dey, Amit K, additional, Belur, Agastya D, additional, Goyal, Aditya, additional, Groenendyk, Jacob W, additional, Chung, Jonathan, additional, Rodante, Justin, additional, Joshi, Aditya A, additional, Playford, Martin P, additional, and Mehta, Nehal N, additional

Published
2018
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132. Abstract P363: Visceral, but Not Subcutaneous Adiposity by Computed Tomography is Associated With Increased Aortic Wall Thickness in Psoriasis Patients

Author

Groenendyk, Jacob W, primary, Shukla, Parag, additional, Elnabawi, Youssef A, additional, Rivers, Joshua P, additional, Goyal, Aditya, additional, Belur, Agastya D, additional, Dey, Amit K, additional, Sadek, Ahmed, additional, Nanda, Navya, additional, Rodante, Justin, additional, Ahlman, Mark A, additional, Joshi, Aditya A, additional, Gelfand, Joel M, additional, Playford, Martin P, additional, and Mehta, Nehal N, additional

Published
2018
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133. Visceral Adiposity in Psoriasis is Associated With Vascular Inflammation by 18F-Fluorodeoxyglucose Positron-Emission Tomography/Computed Tomography Beyond Cardiometabolic Disease Risk Factors in an Observational Cohort Study

Author

Rivers, Joshua P., primary, Powell-Wiley, Tiffany M., additional, Dey, Amit K., additional, Rodante, Justin A., additional, Chung, Jonathan H., additional, Joshi, Aditya A., additional, Natarajan, Balaji, additional, Sajja, Aparna P., additional, Chaturvedi, Abhishek, additional, Rana, Anshuma, additional, Harrington, Charlotte L., additional, Teague, Heather L., additional, Lockshin, Benjamin N., additional, Ahlman, Mark A., additional, Yao, Jianhua, additional, Playford, Martin P., additional, Gelfand, Joel M., additional, and Mehta, Nehal N., additional

Published
2018
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134. Chronic skin inflammation accelerates macrophage cholesterol crystal formation and atherosclerosis

Author

Baumer, Yvonne, primary, Ng, Qimin, additional, Sanda, Gregory E., additional, Dey, Amit K., additional, Teague, Heather L., additional, Sorokin, Alexander V., additional, Dagur, Pradeep K., additional, Silverman, Joanna I., additional, Harrington, Charlotte L., additional, Rodante, Justin A., additional, Rose, Shawn M., additional, Varghese, Nevin J., additional, Belur, Agastya D., additional, Goyal, Aditya, additional, Gelfand, Joel M., additional, Springer, Danielle A., additional, Bleck, Christopher K.E., additional, Thomas, Crystal L., additional, Yu, Zu-Xi, additional, Winge, Mårten C.G., additional, Kruth, Howard S., additional, Marinkovich, M. Peter, additional, Joshi, Aditya A., additional, Playford, Martin P., additional, and Mehta, Nehal N., additional

Published
2018
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136. Cardiovascular risk assessment and management of patients undergoing hematopoietic cell transplantation

Author

Oliveira, Guilherme H., Al-Kindi, Sadeer G., Guha, Avirup, Dey, Amit K., Rhea, Isaac B., and deLima, Marcos J.

Abstract

The purpose of this review is to provide a framework for the cardiovascular evaluation and management of patients undergoing hematopoietic cell transplantation (HCT). To accomplish this, we have performed an extensive literature review, critically analyzed the available evidence, and developed a set of recommendations to guide best practice. Herein, we discuss the cardiovascular risk profile of patients undergoing HCT along with putative mechanisms of HCT-induced cardiovascular injury. We then present an algorithm for cardiovascular testing and risk mitigation of potential recipients. Last, we address the management of the most prevalent cardiovascular conditions associated with HCT recipients.

Published
2021
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137. Characterization of PCSK9 in the Blood and Skin of Psoriasis

Author

Garshick, Michael S., Baumer, Yvonne, Dey, Amit K., Grattan, Ryan, Ng, Qimin, Teague, Heather L., Yu, Zu-Xi, Chen, Marcus Y., Tawil, Michael, Barrett, Tessa J., Underberg, James, Fisher, Edward A., Krueger, James, Powell-Wiley, Tiffany M., Playford, Martin P., Berger, Jeffrey S., and Mehta, Nehal N.

Abstract

Mechanisms explaining the link between psoriasis, a proinflammatory condition, and cardiovascular disease are not fully known. PCSK9 is predominantly expressed in hepatocytes as a critical regulator of lipid metabolism, and clinical trials targeting PCSK9 reduce cardiovascular disease. Independent of its role in lipid metabolism, PCSK9 levels associate with endothelial dysfunction and predict cardiovascular events. We used two separate human psoriasis cohorts and the K14-Rac1V12−/+murine model of psoriasis to investigate PCSK9 and cardiovascular risk in psoriasis. In both psoriasis cohorts (n = 88 and n = 20), PCSK9 levels were 20% and 13% higher than in age-, sex-, and cholesterol-matched controls, respectively (P< 0.05 for each comparison) and correlated with PASI (r = 0.43, P< 0.05). Despite no difference in hepatocyte expression, K14-Rac1V12−/+mice demonstrated skin-specific PCSK9 staining, which was confirmed in human psoriatic lesional skin. In patients with psoriasis, PCSK9 levels correlated with impaired endothelial vascular health (e.g., early atherosclerosis, β = 4.5, P< 0.01) and log converted coronary artery calcium score (β = 0.30, P = 0.01), which remained significant after adjustment for Framingham risk, body mass index, and active biologic use. Taken together, these findings suggest, independent of cholesterol, an association between circulating PCSK9 and early as well as advanced stages of atherosclerosis in psoriasis.

Published
2021
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138. Colaboradores

Author

Allahham, Mahmoud, Arps, Kelly, Ballantyne, Christie M., Belur, Agastya D., Bhat, Pavan, Carman, Teresa L., Chang, Anna Marie, Dadu, Razvan T., Dey, Amit K., Goyal, Aditya, Hoogeveen, Ron, Jneid, Hani, Jones, Peter H., Kleiman, Neal S., McEvoy, John W., Mehta, Nehal N., Milks, M. Wesley, Moyé, Lem, Nambi, Vijay, Neeland, Ian J., Oakland, Morgan, Patel, Kershaw V., Peacock, W. Frank, Riggs, Kayla A., Rohatgi, Anand, Saeed, Anum, Sekhon, Navdeep, Singh, Mohita, Wang, Zhe, Tang, W.H. Wilson, and Yu, Bing

Published
2020
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139. Association Between Skin and Aortic Vascular Inflammation in Patients With Psoriasis

Author

Dey, Amit K., primary, Joshi, Aditya A., additional, Chaturvedi, Abhishek, additional, Lerman, Joseph B., additional, Aberra, Tsion M., additional, Rodante, Justin A., additional, Teague, Heather L., additional, Harrington, Charlotte L., additional, Rivers, Joshua P., additional, Chung, Jonathan H., additional, Kabbany, Mohammad Tarek, additional, Natarajan, Balaji, additional, Silverman, Joanna I., additional, Ng, Qimin, additional, Sanda, Gregory E., additional, Sorokin, Alexander V., additional, Baumer, Yvonne, additional, Gerson, Emily, additional, Prussick, Ronald B., additional, Ehrlich, Alison, additional, Green, Lawrence J., additional, Lockshin, Benjamin N., additional, Ahlman, Mark A., additional, Playford, Martin P., additional, Gelfand, Joel M., additional, and Mehta, Nehal N., additional

Published
2017
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140. Coronary Plaque Characterization in Psoriasis Reveals High-Risk Features That Improve After Treatment in a Prospective Observational Study

Author

Lerman, Joseph B., primary, Joshi, Aditya A., additional, Chaturvedi, Abhishek, additional, Aberra, Tsion M., additional, Dey, Amit K., additional, Rodante, Justin A., additional, Salahuddin, Taufiq, additional, Chung, Jonathan H., additional, Rana, Anshuma, additional, Teague, Heather L., additional, Wu, Jashin J., additional, Playford, Martin P., additional, Lockshin, Benjamin A., additional, Chen, Marcus Y., additional, Sandfort, Veit, additional, Bluemke, David A., additional, and Mehta, Nehal N., additional

Published
2017
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141. Abstract 549: Visceral Adipose Tissue Associates With Coronary Plaque Burden Beyond Cardiovascular Risk Factors in Psoriasis

Author

Rivers, Joshua P, primary, Dey, Amit K, additional, Chung, Jonathan H, additional, Rana, Anshuma, additional, Chaturvedi, Abhishek, additional, Rodante, Justin A, additional, Lerman, Joseph B, additional, Playford, Martin P, additional, Yao, Jianhua, additional, Chen, Marcus Y, additional, Bluemke, David A, additional, Powell-Wiley, Tiffany M, additional, and Mehta, Nehal N, additional

Published
2017
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142. Abstract 175: Glycosylated Hemoglobin is Associated With Coronary Plaque Burden in Psoriasis Beyond Cardiovascular Risk Factors

Author

Chung, Jonathan H, primary, Rana, Anshuma, additional, Dey, Amit K, additional, Rivers, Joshua P, additional, Chaturvedi, Abhishek, additional, Lerman, Joseph B, additional, Rodante, Justin A, additional, Harrington, Charlotte L, additional, Playford, Martin P, additional, Chen, Marcus Y, additional, Bluemke, David A, additional, and Mehta, Nehal N, additional

Published
2017
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144. Abstract P039: Lipid Rich Plaque by Coronary CT Angiography Associates With Cholesterol Efflux Capacity Independent of Traditional Cardiovascular Risk Factors in Those at Risk for Myocardial Infarction

Author

Chung, Jonathan H, primary, Dey, Amit K, additional, Chaturvedi, Abhishek, additional, Rivers, Joshua P, additional, Lerman, Joseph B, additional, Harrington, Charlotte L, additional, Ahlman, Mark, additional, Playford, Martin P, additional, Gordon, Scott M, additional, Joshi, Aditya A, additional, Remaley, Alan T, additional, Chen, Marcus, additional, Bluemke, David A, additional, and Mehta, Nehal N, additional

Published
2017
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145. Abstract MP046: Visceral Adipose Tissue but Not Subcutaneous Adipose Tissue Associates With Cholesterol Efflux Capacity in Psoriasis

Author

Rivers, Joshua P, primary, Dey, Amit K, additional, Chaturvedi, Abhishek, additional, Chung, Jonathan H, additional, Kabbany, Mohammad Tarek, additional, Ahlman, Mark A, additional, Rodante, Justin A, additional, Joshi, Aditya A, additional, Harrington, Charlotte L, additional, Playford, Martin P, additional, Yao, Jianhua, additional, Powell-Wiley, Tiffany M, additional, and Mehta, Nehal N, additional

Published
2017
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147. Abstract 12607: Improvement in Skin Inflammation Associates With Improvement in Aortic Vascular Inflammation by 18-FDG PET/CT in Psoriasis

Author

Dey, Amit K, primary, Lerman, Joseph B, additional, Aberra, Tsion M, additional, Chaturvedi, Abhishek, additional, Kabbany, Mohammad T, additional, Joshi, Aditya A, additional, Rodante, Justin A, additional, Silverman, Joanna I, additional, Dahiya, Asha, additional, Shukla, Parag, additional, Natarajan, Balaji, additional, Teague, Heather L, additional, Salahuddin, Taufiq, additional, Ng, Qimin, additional, Aridi, Tarek Z, additional, Playford, Martin P, additional, Lockshin, Benjamin N, additional, Ahlman, Mark A, additional, Chen, Marcus Y, additional, Gelfand, Joel M, additional, and Mehta, Nehal N, additional

Published
2016
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148. Abstract 12608: Coronary Artery Plaque Burden Characterization in Psoriasis Reveals Increase in High Risk Plaque

Author

Lerman, Joseph B, primary, Chaturvedi, Abhishek, additional, Dey, Amit K, additional, Aberra, Tsion M, additional, Joshi, Aditya A, additional, Kabbany, Mohammad T, additional, Salahuddin, Taufiq, additional, Yunus, Raza, additional, Silverman, Joanna I, additional, Rodante, Justin A, additional, Playford, Martin P, additional, Chen, Marcus Y, additional, Sandfort, Veit, additional, Bluemke, David A, additional, and Mehta, Nehal N, additional

Published
2016
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149. Abstract 12605: Brain Metabolic Activity Within Regions Involved in Stress Perception Associates Directly With Arterial Inflammation and Inversely With Aortic Distensibility in Psoriasis

Author

Aberra, Tsion M, primary, Chaturvedi, Abhishek, additional, Lerman, Joseph B, additional, Dey, Amit K, additional, Shukla, Parag, additional, Joshi, Aditya A, additional, Rodante, Justin A, additional, Silverman, Joanna I, additional, Ng, Qimin, additional, Teague, Heather L, additional, Ahlman, Mark A, additional, Bluemke, David A, additional, Playford, Martin P, additional, Tawakol, Ahmed A, additional, and Mehta, Nehal N, additional

Published
2016
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150. Abstract 12593: Improvement in Aortic Vascular Inflammation by 18-FDG PET/CT Associates With Reduction in Aortic Wall Thickness by MRI

Author

Kabbany, Mohammad T, primary, Dey, Amit K, additional, Shukla, Parag, additional, Chaturvedi, Abhishek, additional, Lerman, Joseph B, additional, Aberra, Tsion M, additional, Joshi, Aditya A, additional, Silverman, Joanna I, additional, Ng, Qimin, additional, Teague, Heather L, additional, Dahiya, Asha, additional, Rodante, Justin A, additional, Ahlman, Mark A, additional, Playford, Martin P, additional, and Mehta, Nehal N, additional

Published
2016
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