101. Effects of anti-TNF-α treatment on lipid profile in rheumatic diseases: an analytical cohort study
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Uzi Milman, Idit Lavi, Devy Zisman, Shai Cohen, Joy Feld, Shadi Hassan, and Lihi Eder
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Adult ,Male ,medicine.medical_specialty ,Statin ,medicine.drug_class ,030204 cardiovascular system & hematology ,Gastroenterology ,Cohort Studies ,03 medical and health sciences ,Psoriatic arthritis ,0302 clinical medicine ,Internal medicine ,Rheumatic Diseases ,medicine ,Humans ,Rheumatoid arthritis ,TNF-α inhibitors ,Aged ,Retrospective Studies ,030203 arthritis & rheumatology ,biology ,medicine.diagnostic_test ,business.industry ,Tumor Necrosis Factor-alpha ,Retrospective cohort study ,Middle Aged ,medicine.disease ,Lipids ,Rheumatology ,Lipid profile ,Cardiovascular Diseases ,Antirheumatic Agents ,HMG-CoA reductase ,biology.protein ,Female ,Hydroxymethylglutaryl-CoA Reductase Inhibitors ,business ,Lipoprotein ,Research Article ,Ankylosing spondylitis - Abstract
Background The aim was to assess the influence of long-term treatment with tumor necrosis factor alpha (TNF-α) inhibitors on total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), high-density lipoprotein (HDL), and atherogenic index (AI) in rheumatoid arthritis (RA), psoriatic arthritis (PsA), and ankylosing spondylitis (AS) patients. Methods A retrospective cohort study was conducted on RA, PsA, and AS patients treated with TNF-α inhibitors for at least 270 days between 2001 and 2011. Levels of TC, TG, LDL, and HDL and the AI were compared with baseline values at 0–6, 6–12, 12–18, and 18–24 months. Patients were further subdivided into three groups according to their HMG CoA reductase inhibitor (statin) treatment status in order to assess their effect on the results. Results The records of 311 patients (152 RA, 90 PsA, and 69 AS) were reviewed. TC and TG increased following treatment with TNF-α inhibitors, from 180.85 ± 2.12 mg/dl and 116.00 ± 3.55 mg/dl at baseline to 188.12 ± 2.35 mg/dl (p = 0.02) and 132.02 ± 4.63 mg/dl at 0–6 months (p
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