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The increased cost of doing business domestically and the impact of global competition are two reasons companies establish plants in foreign locations. To have a successful global business, manufacturers must have an effective global supply chain infrastructure, which requires effective information technology. Firms now routinely consider remote domestic and international locations when evaluating potential sites. Many factors must be considered when choosing the right location for manufacturing facilities. These include: physical infrastructure, proximity to suppliers and customers, tax considerations, international trade conditions, and as this research explored, telecommunications infrastructure. This study examined the degree to which the telecommunications infrastructure impacts the decision to select a specific foreign manufacturing site for the organisation. The results of four case studies of electronics firms indicated that telecommunications is a necessity to conduct business. Two of the firms indicated that telecommunications was considered in their most recent site selection. Although the other two firms did not overtly consider telecommunications in the site selection criteria, they did indicate that it is critical to the success of the company in a global market.

Drosophila photoreceptor cells (R cells) develop from the eye imaginal during the third instar larval stage and acquire their adult morphology during pupation. We show that orthodenticle (otd), a homeobox gene, is required for R-cell morphogenesis during pupation. otdUV-insensitive (otduvi) is a hypomorphic allele of otd that only affects R-cell development. The R-cell rhabdomeres are disorganized in otduvi, and there is a disruption of proximal-distal development in the eye. The otd genomic structure was determined and resulted in the identification of a deletion in the third intron of otduvi. Sequences encompassing this deletion are able to direct expression of the lacZ reporter gene at all stages of the developing visual system, including the photosensitive cells of Bolwig's organ, the ocelli, and the adult eye. The third intron enhancer is the primary regulatory element controlling otd in the R cells and is not under the control of the glass gene.

Background Spasticity is a motor disorder that causes significant disability and impairs function. There are no definitive parameters that assess spasticity and there is no universally accepted definition. Spasticity evaluation is important in determining stages of recovery. It can determine treatment effectiveness as well as how treatment should proceed. This paper presents a novel cross sectional robotic pilot study for the primary purpose of assessment. The system collects force and position data to quantify spasticity through similar motions of the Modified Ashworth Scale (MAS) assessment in the Sagittal plane. Validity of the system is determined based on its ability to measure velocity dependent resistance. Methods Forty individuals with Acquired Brain Injury (ABI) and 45 healthy individuals participated in a robotic pilot study. A linear regression model was applied to determine the effect an ABI has on force data obtained through the robotic system in an effort to validate it. Parameters from the model were compared for both groups. Two techniques were performed in an attempt to classify between healthy and patients. Dynamic Time Warping (DTW) with k-nearest neighbour (KNN) classification is compared to a time-series algorithm using position and force data in a linear discriminant analysis (LDA). Results The system is capable of detecting a velocity dependent resistance (p