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417 results on '"Deng, Wei‐Wei"'

107. γ‐Secretase inhibitor reduces immunosuppressive cells and enhances tumour immunity in head and neck squamous cell carcinoma

Author

Mao, Liang, primary, Zhao, Zhi‐Li, additional, Yu, Guang‐Tao, additional, Wu, Lei, additional, Deng, Wei‐Wei, additional, Li, Yi‐Cun, additional, Liu, Jian‐Feng, additional, Bu, Lin‐Lin, additional, Liu, Bing, additional, Kulkarni, Ashok B., additional, Zhang, Wen‐Feng, additional, Zhang, Lu, additional, and Sun, Zhi‐Jun, additional

Published
2017
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114. Antitumor Platelet-Mimicking Magnetic Nanoparticles

Author

Rao, Lang, primary, Bu, Lin-Lin, additional, Meng, Qian-Fang, additional, Cai, Bo, additional, Deng, Wei-Wei, additional, Li, Andrew, additional, Li, Kaiyang, additional, Guo, Shi-Shang, additional, Zhang, Wen-Feng, additional, Liu, Wei, additional, Sun, Zhi-Jun, additional, and Zhao, Xing-Zhong, additional

Published
2017
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118. Inhibition of STAT3 reduces proliferation and invasion in salivary gland adenoid cystic carcinoma

Author

Bu, Lin-Lin, Deng, Wei-Wei, Huang, Cong-Fa, Liu, Bing, Zhang, Wen-Feng, and Sun, Zhi-Jun

Subjects
Original Article
Abstract

In this study, we accessed the expression and correlation of p-STAT3 with Survivin, Cyclin D1, CD147, Slug and Ki67 by immunohistochemical staining of human tissue microarray which contains 72 adenoid cystic carcinoma (AdCC), 12 pleomorphic adenoma (PMA) and 18 normal salivary gland (NSG) using digital pathological scanner and scoring system. We found that the expression of p-STAT3, Survivin, Slug, Cyclin D1 and CD147 was significantly increased in AdCC as compared with PMA and (or) NSG (p0.05). Correlation analysis of these proteins revealed that p-STAT3 up-regulates the expression of Survivin, Slug, Cyclin D1 and CD147 (p

Published
2015

119. LAIR‐1 overexpression and correlation with advanced pathological grade and immune suppressive status in oral squamous cell carcinoma.

Author

Yang, Lei‐Lei, Zhang, Meng‐Jie, Wu, Lei, Mao, Liang, Chen, Lei, Yu, Guang‐Tao, Deng, Wei‐Wei, Zhang, Wen‐Feng, Liu, Bing, Sun, Wei‐Ke, and Sun, Zhi‐Jun

Subjects
SQUAMOUS cell carcinoma
Abstract

Background: This study aims to investigate the characteristic role of inhibitory receptor leukocyte‐associated immunoglobulin‐like receptor 1 (LAIR‐1) in oral squamous cell carcinoma (OSCC). Methods: The expressions of LAIR‐1 and other immune‐related molecules were detected in a human OSCC tissue microarray. LAIR‐1 expression difference among different clinicopathological parameters was analyzed. The correlations of LAIR‐1 with several immune‐related markers were assessed. Results: Compared with dysplasia and oral mucosa, the expression of LAIR‐1 was significantly upregulated in the stroma of OSCC, and its overexpression was correlated with advanced pathological grade. Overexpression of LAIR‐1 was significantly associated with tumor‐associated macrophage and myeloid‐derived suppressor cell markers (CD68, CD163; CD33, CD11b), indoleamine 2,3‐dioxygenase (IDO) and two immune checkpoints (B7‐H3 and VISTA). Conclusions: Overexpression of LAIR‐1 was associated with advanced pathological grade and correlated with immune suppressive features in OSCC. Further studies are required to identify the specific immunological role of LAIR‐1. [ABSTRACT FROM AUTHOR]

Published
2019
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127. Caffeine Content and Related Gene Expression: Novel Insight into Caffeine Metabolism in CamelliaPlants Containing Low, Normal, and High Caffeine Concentrations

Author

Zhu, Biying, Chen, Lin-Bo, Lu, Mengqian, Zhang, Jing, Han, Jieyun, Deng, Wei-Wei, and Zhang, Zheng-Zhu

Abstract

Caffeine is a crucial secondary metabolic product in tea plants. Although the presence of caffeine in tea plants has been identified, the molecular mechanisms regulating relevant caffeine metabolism remain unclear. For the elucidation of the caffeine biosynthesis and catabolism in Camelliaplants, fresh, germinated leaves from four Camelliaplants with low (2), normal (1), and high (1) caffeine concentrations, namely, low-caffeine tea 1 (LCT1, Camellia crassicolumna), low-caffeine tea 2 (LCT2, C. crassicolumna), Shuchazao (SCZ, C. sinensis), and Yunkang 43 (YK43, C. sinensis) were used in this research. Transcriptome and purine alkaloids analyses of these Camellialeaves were performed using RNA-Seq and liquid chromatography–mass spectrometry (LC–MS). Moreover, 15N-caffeine tracing was performed to determine the metabolic fate of caffeine in leaves of these plants. Caffeine content was correlated with related gene expression levels, and a quantitative real-time (qRT) PCR analysis of specific genes showed a consistent tendency with the obtained transcriptomic analysis. On the basis of the results of stable isotope-labeled tracer experiments, we discovered a degradation pathway of caffeine to theobromine. These findings could assist researchers in understanding the caffeine-related mechanisms in Camelliaplants containing low, normal, and high caffeine content and be applied to caffeine regulation and breeding improvement in future research.

Published
2019
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135. Inhibition of SRC family kinases reduces myeloid-derived suppressor cells in head and neck cancer.

Author

Mao, Liang, Deng, Wei‐Wei, Yu, Guang‐Tao, Bu, Lin‐Lin, Liu, Jian‐Feng, Ma, Si‐Rui, Wu, Lei, Kulkarni, Ashok B., Zhang, Wen‐Feng, and Sun, Zhi‐Jun

Abstract

SRC family kinases (SFKs), a group of nonreceptor tyrosine kinases, modulate multiple cellular functions, such as cell proliferation, differentiation and metabolism. SFKs display aberrant activity in progressive stages of human cancers. However, the precise role of SFKs in the head and neck squamous cell carcinoma (HNSCC) signaling network is far from clear. In this study, we found that the inhibition of SFKs activity by dasatinib effectively reduced the tumor size and population of MDSCs in the HNSCC mouse model. Molecular analysis indicates that phosphorylation of LYN, rather than SRC, was inhibited by dasatinib treatment. Next, we analyzed LYN expression by immunostaining and found that it was overexpressed in the human HNSCC specimens. Moreover, LYN expression in stromal cells positively correlated with myeloid-derived suppressor cells (MDSCs) makers CD11b and CD33 in human HNSCC. The dual positive expression of LYN in epithelial and stromal cells (EPI+ SRT+) was associated with unfavorable overall survival of HNSCC patients. These findings indicate that SFKs may be a potential target for an effective immunotherapy of HNSCC by decreasing MDSCs and moreover, LYN will have an impact on such therapeutic strategy. [ABSTRACT FROM AUTHOR]

Published
2017
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136. Short Implants (5 to 8 mm) Versus Longer Implants (>8 mm) with Sinus Lifting in Atrophic Posterior Maxilla: A Meta-Analysis of RCTs.

Author

Fan, Tengfei, Li, Yicun, Deng, Wei‐Wei, Wu, Tianfu, and Zhang, Wenfeng

Subjects
ALVEOLAR process, MAXILLA, CLINICAL trials, DENTAL implants, ORAL surgery
Abstract

ABSTRACT Objective The specific purposes of this study were (1) to undertake a thorough systematic review and meta-analysis based only on randomized clinical trials (RCTs) to compare the rates of survival and complications of short implants to those of long implants; (2) to compare the surgical time and cost of short implants to those of long implants. Methods RCTs were identified from the major electronic databases (MEDLINE, Embase and Cochrane Library) using the keywords 'dental implant,' 'short implant' and 'atrophic maxilla,' and a quantitative meta-analysis was conducted. The survival rate of implants and complications were the primary outcome measures, and other parameters assessed included costs and surgical time. Results Seven RCTs that met the inclusion criteria included 554 implants (265 implants in the short implant group). There was no significant difference in survival rate between two groups (RR: 1.00; 95% CI: [0.97, 1.03]; p = .96; seven trials, 554 participants). Compared with long implant group, the short implant group had a lower complications and the effect measure was significant (RR: 0.58; 95% CI: [0.37, 0.90]; p = .02; seven trials, 554 participants). Conclusion This systematic review showed that no difference between the survival rates of short implants (5-8 mm) and long implants (>8 mm); complications in short implants are lower than that in long implants. However, further studies are required to substantiate our findings. [ABSTRACT FROM AUTHOR]

Published
2017
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