101. MDR1 Haplotype Frequencies in Japanese and Caucasian, and in Japanese Patients with Colorectal Cancer and Esophageal Cancer
- Author
-
Chiho Komoto, Hideaki Omatsu, Tsutomu Nakamura, Toshiyuki Sakaeda, Deanna L. Kroetz, Noboru Okamura, Katsuhiko Okumura, Ikuya Miki, Nobuo Aoyama, Takao Tamura, Masato Kasuga, Tatsuya Koyama, and Toshio Yamada
- Subjects
Adult ,Male ,medicine.medical_specialty ,Pathology ,Esophageal Neoplasms ,Genotype ,Colorectal cancer ,Pharmaceutical Science ,Antineoplastic Agents ,Single-nucleotide polymorphism ,Gastroenterology ,White People ,Gene Frequency ,Japan ,Internal medicine ,medicine ,Humans ,Pharmacology (medical) ,Allele ,Allele frequency ,Aged ,Aged, 80 and over ,Pharmacology ,business.industry ,Haplotype ,DNA ,Middle Aged ,Esophageal cancer ,medicine.disease ,Genotype frequency ,Treatment Outcome ,Haplotypes ,Female ,Genes, MDR ,Colorectal Neoplasms ,business - Abstract
The genotype frequencies of MDR1 T-129C, C1236T, G2677A,T and C3435T SNPs were compared in 154 healthy Japanese and 100 healthy Caucasians to provide basic information on the inter-ethnic differences of pharmacotherapeutic outcome. The variants were found at allelic frequencies of 5.5%, 65.6%, 16.6%, 40.6% and 40.6%, for T-129C, C1236T, G2677A, G2677T and C3435T, respectively, in Japanese, and at 5.1%, 45.9%, 3.6%, 46.4% and 56.6%, respectively, in Caucasians, with a statistically significant difference for C1236T, G2677A,T and C3435T (p
- Published
- 2006