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705 results on '"DeCaprio, James A."'

105. Subtype Heterogeneity and Epigenetic Convergence in Neuroendocrine Prostate Cancer

Author

Cejas, Paloma, primary, Xie, Yingtian, additional, Font-Tello, Alba, additional, Lim, Klothilda, additional, Syamala, Sudeepa, additional, Qiu, Xintao, additional, Tewari, Alok K., additional, Shah, Neel, additional, Nguyen, Holly M, additional, Patel, Radhika A., additional, Brown, Lisha, additional, Coleman, Ilsa, additional, Hackeng, Wenzel M., additional, Brosens, Lodewijk, additional, Dreijerink, Koen M.A., additional, Ellis, Leigh, additional, Abou Alaiwi, Sarah, additional, Seo, Ji-Heui, additional, Pomerantz, Mark, additional, Dall’Agnese, Alessandra, additional, Crowdis, Jett, additional, Van Allen, Eliezer M., additional, Bellmunt, Joaquim, additional, Morrisey, Colm, additional, Nelson, Peter S., additional, DeCaprio, James, additional, Farago, Anna, additional, Dyson, Nicholas, additional, Drapkin, Benjamin, additional, Liu, X. Shirley, additional, Freedman, Matthew, additional, Haffner, Michael C., additional, Corey, Eva, additional, Brown, Myles, additional, and Long, Henry W., additional

Published
2020
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109. Association of Programmed Death 1 Protein Ligand (PD-L1) Expression With Prognosis in Merkel Cell Carcinoma

Author

Hanna, Glenn J., primary, Kacew, Alec J., additional, Tanguturi, Anusha R., additional, Grote, Hans J., additional, Vergara, Victoria, additional, Brunkhorst, Beatrice, additional, Rabinowits, Guilherme, additional, Thakuria, Manisha, additional, LeBoeuf, Nicole R., additional, Ihling, Christian, additional, DeCaprio, James A., additional, and Lorch, Jochen H., additional

Published
2020
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110. KRT-232, a first-in-class, murine double minute 2 inhibitor (MDM2i), for TP53 wild-type (p53WT) Merkel cell carcinoma (MCC) after anti–PD-1/L1 immunotherapy.

Author

Wong, Michael K.K., primary, Kelly, Ciara Marie, additional, Burgess, Melissa Amber, additional, Lewis, Karl, additional, Grewal, Jaspreet Singh, additional, Olszanski, Anthony J., additional, McGreivy, Jesse, additional, Rothbaum, Wayne, additional, Qamoos, Hope, additional, and DeCaprio, James A., additional

Published
2020
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113. Abstract B06: Investigating the microbial etiology of Tanzanian esophageal squamous cell carcinoma

Author

Nomburg, Jason, primary, Bullman, Susan, additional, Collisson, Eric, additional, Mushi, Beatrice, additional, Seleka, Msiba, additional, Vaske, Charlie, additional, Newton, Yulia, additional, Radenbuagh, Amie, additional, Akoko, Larry, additional, DeCaprio, James A., additional, Meyerson, Matthew, additional, Mmbaga, Elia J., additional, and Van Loon, Katherine, additional

Published
2020
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114. ViroPanel

Author

Slevin, Michael K., primary, Wollison, Bruce M., additional, Powers, Winslow, additional, Burns, Robert T., additional, Patel, Neil, additional, Ducar, Matthew D., additional, Starrett, Gabriel J., additional, Garcia, Elizabeth P., additional, Manning, Danielle K., additional, Cheng, Jingwei, additional, Hanna, Glenn J., additional, Kaye, Kenneth M., additional, Van Hummelen, Paul, additional, Nag, Anwesha, additional, Thorner, Aaron R., additional, DeCaprio, James A., additional, and MacConaill, Laura E., additional

Published
2020
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118. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

Author

Kim, Jong Wook, primary, Berrios, Christian, additional, Kim, Miju, additional, Schade, Amy E, additional, Adelmant, Guillaume, additional, Yeerna, Huwate, additional, Damato, Emily, additional, Iniguez, Amanda Balboni, additional, Florens, Laurence, additional, Washburn, Michael P, additional, Stegmaier, Kim, additional, Gray, Nathanael S, additional, Tamayo, Pablo, additional, Gjoerup, Ole, additional, Marto, Jarrod A, additional, DeCaprio, James, additional, and Hahn, William C, additional

Published
2020
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119. Author response: STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation of human cells

Author

Kim, Jong Wook, primary, Berrios, Christian, additional, Kim, Miju, additional, Schade, Amy E, additional, Adelmant, Guillaume, additional, Yeerna, Huwate, additional, Damato, Emily, additional, Iniguez, Amanda Balboni, additional, Florens, Laurence, additional, Washburn, Michael P, additional, Stegmaier, Kim, additional, Gray, Nathanael S, additional, Tamayo, Pablo, additional, Gjoerup, Ole, additional, Marto, Jarrod A, additional, DeCaprio, James, additional, and Hahn, William C, additional

Published
2020
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124. Inhibition of cellular proliferation by the Wilms tumor suppressor WT1 requires association with the inducible chaperone Hsp70

Author

Maheswaran, Shyamala, Englert, Christoph, Zheng, Gang, Lee, Sean Bong, Wong, Jenise, Harkin, D. Paul, Bean, James, Ezzell, Robert, Garvin, A. Julian, McCluskey, Robert T., DeCaprio, James A., and Haber, Daniel A.

Subjects
Kidney glomerulus -- Research, Cell differentiation -- Genetic aspects, Gene expression -- Research, Genetic transcription -- Regulation, Tumor suppressor genes -- Research, Biological sciences
Abstract

A major cellular protein associated with endogenous WT1 has been identified by immunoprecipitation and protein microsequencing analysis as the inducible chaperone Hsp70. WT1, the Wilms tumor suppressor, codes a zinc finger transcription factor expressed in glomerular podocytes during a short time period in kidney development. WT1 and Hsp70 are close in primary Wilms tumor specimens, in rat embryo kidney cells, and in cells in culture with inducible expression of WT1. It appears that Hsp70 is an important cofactor for WT1 and that the chaperone may be a factor during kidney differentiation.

Published
1998

127. Ras signalling linked to the cell-cycle machinery by the retinoblastoma protein

Author

Peeper, Daniel S., Upton, Todd M., Ladha, Mohamed H., Neuman, Elizabeth, Zalvide, Juan, Bernards, Rene, DeCaprio, James A., and Ewen, Mark E.

Subjects
Tumor proteins -- Analysis, Proto-oncogenes -- Analysis, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

The Ras proto-oncogene which is the major component needed by the cells to pass through the G1/S transition of the cell-cycle is functionally linked to retinoblastoma tumour-suppressor protein (Rb). Any disruption of Rb can cause failure of the cells to arrest in G1 following the inactivation of Ras. Rb is an important G1-specific mediator that connects Ras to cell-cycle regulation.

Published
1997

132. STRIPAK directs PP2A activity toward MAP4K4 to promote oncogenic transformation

Author

Kim, Jong Wook, primary, Berrios, Christian, additional, Kim, Miju, additional, Schade, Amy E., additional, Adelmant, Guillaume, additional, Yeerna, Huwate, additional, Damato, Emily, additional, Iniguez, Amanda Balboni, additional, Swanson, Selene K., additional, Florens, Laurence, additional, Washburn, Michael P., additional, Stegmaier, Kim, additional, Gray, Nathaniel S., additional, Tamayo, Pablo, additional, Gjoerup, Ole, additional, Marto, Jarrod A., additional, DeCaprio, James A., additional, and Hahn, William C., additional

Published
2019
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133. The Genomic Landscape of Merkel Cell Carcinoma and Clinicogenomic Biomarkers of Response to Immune Checkpoint Inhibitor Therapy

Author

Knepper, Todd C., primary, Montesion, Meagan, additional, Russell, Jeffery S., additional, Sokol, Ethan S., additional, Frampton, Garrett M., additional, Miller, Vincent A., additional, Albacker, Lee A., additional, McLeod, Howard L., additional, Eroglu, Zeynep, additional, Khushalani, Nikhil I., additional, Sondak, Vernon K., additional, Messina, Jane L., additional, Schell, Michael J., additional, DeCaprio, James A., additional, Tsai, Kenneth Y., additional, and Brohl, Andrew S., additional

Published
2019
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137. Clinical and molecular characterization of virus-positive and virus-negative Merkel cell carcinoma

Author

Starrett, Gabriel J., primary, Thakuria, Manisha, additional, Chen, Tianqi, additional, Marcelus, Christina, additional, Cheng, Jingwei, additional, Nomburg, Jason, additional, Thorner, Aaron R., additional, Slevin, Michael K., additional, Powers, Winslow, additional, Burns, Robert T., additional, Perry, Caitlin, additional, Piris, Adriano, additional, Kuo, Frank C., additional, Rabinowits, Guilherme, additional, Giobbie-Hurder, Anita, additional, MacConaill, Laura E., additional, and DeCaprio, James A., additional

Published
2019
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139. DYRK1A regulates the recruitment of 53BP1 to the sites of DNA damage in part through interaction with RNF169

Author

R. Menon, Vijay, primary, Ananthapadmanabhan, Varsha, additional, Swanson, Selene, additional, Saini, Siddharth, additional, Sesay, Fatmata, additional, Yakovlev, Vasily, additional, Florens, Laurence, additional, DeCaprio, James A., additional, P. Washburn, Michael, additional, Dozmorov, Mikhail, additional, and Litovchick, Larisa, additional

Published
2019
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141. SPOP Promotes Nanog Destruction to Suppress Stem Cell Traits and Prostate Cancer Progression

Author

Zhang, Jinfang, primary, Chen, Ming, additional, Zhu, Yasheng, additional, Dai, Xiangpeng, additional, Dang, Fabin, additional, Ren, Junming, additional, Ren, Shancheng, additional, Shulga, Yulia V., additional, Beca, Francisco, additional, Gan, Wenjian, additional, Wu, Fei, additional, Lin, Yu-Min, additional, Zhou, Xiaobo, additional, DeCaprio, James A., additional, Beck, Andrew H., additional, Lu, Kun Ping, additional, Huang, Jiaoti, additional, Zhao, Cheryl, additional, Sun, Yinghao, additional, Gao, Xu, additional, Pandolfi, Pier Paolo, additional, and Wei, Wenyi, additional

Published
2019
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145. Addiction of Merkel cell carcinoma to MUC1-C identifies a potential new target for treatment

Author

Morimoto, Yoshihiro, Fushimi, Atsushi, Yamashita, Nami, Hagiwara, Masayuki, Bhattacharya, Atrayee, Cheng, Jingwei, Frost, Thomas C., Ahmad, Rehan, Daimon, Tatsuaki, Huang, Lei, Hata, Tsuyoshi, Takahashi, Hidekazu, Yamamoto, Masaaki, Suzuki, Yozo, DeCaprio, James A., and Kufe, Donald

Abstract

Merkel cell carcinoma (MCC) is an aggressive malignancy with neuroendocrine (NE) features, limited treatment options, and a lack of druggable targets. There is no reported involvement of the MUC1-C oncogenic protein in MCC progression. We show here that MUC1-C is broadly expressed in MCCs and at higher levels in Merkel cell polyomavirus (MCPyV)-positive (MCCP) relative to MCPyV-negative (MCCN) tumors. Our results further demonstrate that MUC1-C is expressed in MCCP, as well as MCCN, cell lines and regulates common sets of signaling pathways related to RNA synthesis, processing, and transport in both subtypes. Mechanistically, MUC1-C (i) interacts with MYCL, which drives MCC progression, (ii) is necessary for expression of the OCT4, SOX2, KLF4, MYC, and NANOG pluripotency factors, and (iii) induces the NEUROD1, BRN2 and ATOH1 NE lineage dictating transcription factors. We show that MUC1-C is also necessary for MCCP and MCCN cell survival by suppressing DNA replication stress, the p53 pathway, and apoptosis. In concert with these results, targeting MUC1-C genetically and pharmacologically inhibits MCC self-renewal capacity and tumorigenicity. These findings demonstrate that MCCP and MCCN cells are addicted to MUC1-C and identify MUC1-C as a potential target for MCC treatment.

Published
2022
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148. Epidemiology, biology and therapy of Merkel cell carcinoma: conclusions from the EU project IMMOMEC

Author

Becker, Juergen C., Stang, Andreas, zur Hausen, Axel, Fischer, Nicole, DeCaprio, James A., Tothill, Richard W., Lyngaa, Rikke, Hansen, Ulla Kring, Ritter, Cathrin, Nghiem, Paul, Bichakjian, Christopher K., Ugurel, Selma, Schrama, David, Becker, Juergen C., Stang, Andreas, zur Hausen, Axel, Fischer, Nicole, DeCaprio, James A., Tothill, Richard W., Lyngaa, Rikke, Hansen, Ulla Kring, Ritter, Cathrin, Nghiem, Paul, Bichakjian, Christopher K., Ugurel, Selma, and Schrama, David

Abstract

Merkel cell carcinoma (MCC) is a highly aggressive, often lethal neuroendocrine cancer. Its carcinogenesis may be either caused by the clonal integration of the Merkel cell polyomavirus into the host genome or by UV-induced mutations. Notably, virally-encoded oncoproteins and UV-induced mutations affect comparable signaling pathways such as RB restriction of cell cycle progression or p53 inactivation. Despite its low incidence, MCC recently received much attention based on its exquisite immunogenicity and the resulting major success of immune modulating therapies. Here, we summarize current knowledge on epidemiology, biology and therapy of MCC as conclusion of the project 'Immune Modulating strategies for treatment of Merkel Cell Carcinoma', which was funded over a 5-year period by the European Commission to investigate innovative immunotherapies for MCC.

Published
2018

150. Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping

Author

Baca, Sylvan C., Seo, Ji-Heui, Davidsohn, Matthew P., Fortunato, Brad, Semaan, Karl, Sotudian, Shahabbedin, Lakshminarayanan, Gitanjali, Diossy, Miklos, Qiu, Xintao, El Zarif, Talal, Savignano, Hunter, Canniff, John, Madueke, Ikenna, Saliby, Renee Maria, Zhang, Ziwei, Li, Rong, Jiang, Yijia, Taing, Len, Awad, Mark, Chau, Cindy H., DeCaprio, James A., Figg, William D., Greten, Tim F., Hata, Aaron N., Hodi, F. Stephen, Hughes, Melissa E., Ligon, Keith L., Lin, Nancy, Ng, Kimmie, Oser, Matthew G., Meador, Catherine, Parsons, Heather A., Pomerantz, Mark M., Rajan, Arun, Ritz, Jerome, Thakuria, Manisha, Tolaney, Sara M., Wen, Patrick Y., Long, Henry, Berchuck, Jacob E., Szallasi, Zoltan, Choueiri, Toni K., and Freedman, Matthew L.

Published
2024
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