Search

Your search keyword '"De Sole P"' showing total 313 results
Start Over Author "De Sole P"
313 results on '"De Sole P"'

108. Antibacterial and antioxidant leaf franctions from Actinidia chinensis

Author

BASILE A., SORBO S., VUOTTO M.L., SEPE J., MIRANDO R., JELPO MTL, SIMEONE I., MAESTRALE M., RICCIARDI L., DE SOLE P., MONTESANO D., FERRARA, LYDIA, Basile, A., Sorbo, S., Vuotto, M. L., Sepe, J., Mirando, R., Jelpo, Mtl, Simeone, I., Maestrale, M., Ricciardi, L., DE SOLE, P., Ferrara, Lydia, and Montesano, D.

Abstract

In press

Published
2001

109. Effects of 1,4-butanediol dimethacrylate and urethane dimethacrylate on HL-60 cell metabolism

Author

Nocca G., Martorana G., De Sole P., De Palma F., Callà C., Corsale P., Antenucci M., Gambarini G., Chimenti C., Giardina B., and Lupi A.

Abstract

The polymerization of methacrylic monomers present in dental composite resins never reaches completion and therefore the leakage of residual monomers into the oral cavity and into biological fluids can cause local and systemic adverse effects. This work was carried out to study the in vitro biochemical interactions of urethane dimethacrylate and 1,4-butanediol dimethacrylate monomers with HL-60 cells, a cell line assumed as an experimental model for simulating granulocyte behaviour. Our main finding was that both monomers induce cell differentiation at toxic concentrations and that cytotoxicity seems to be caused by alterations of glucose metabolism arising from mitochondrial dysfunction rather than from oxidative stress, which could not be altogether verified under our experimental conditions. Our study could be considered as a useful approach to investigate the biochemical mechanisms that contribute to the cytotoxicity of methacrylate compounds and it underlines the importance of assessing such parameters for testing biocompatibility in order to promote the development of better and safer dental materials.

Published
2009

115. Alteration of monocytic cell oxidative burst caused by methacrylic monomers present in dental materials: a chemiluminescence study

Author

Nocca G, De Sole P, Gambarini G, De Palma F, Parziale V, Giardina B, and Lupi A.

Abstract

Methacrylates are present in dental composite resins used in clinical practice. Methacrylates are photo-polymerized, but this reaction is never complete, so release of uncured monomers in the periapical tissues and in biological fluids may happen and, potentially, alter the repair of pulpal and of periapical lesions by interfering with local phagocytes. The aim of this study was the evaluation of the functional activity of the monocyte-macrophage system after incubation with methacrylic monomers. The oxidative burst of two cellular systems was analysed using the chemiluminescence technique. Data were collected and statistically analysed. Monomers were found to reduce the in vitro oxidative burst of phagocytes independently from their cytotoxicity. These findings demand further evaluation of the effects of oxidative burst alteration in monocyte-macrophage function and may prompt the inclusion of the described chemiluminescence test in biocompatibility preliminary studies of dental materials.

Published
2006

116. Effect of cigarette smoke extract on the polymorphonuclear leukocytes chemiluminescence: influence of a filter containing glutathione

Author

Donata Scribano, Bruno Giardina, De Sole P, Silvia Persichilli, Angelo Minucci, Bruno Zappacosta, and Silvia Fasanella

Subjects
Time Factors, Neutrophils, Biophysics, Tobacco smoke, law.invention, chemistry.chemical_compound, law, medicine, Cigarette smoke, Humans, Chemiluminescence, chemistry.chemical_classification, Smoke, Chemistry, Smoking, Glutathione, Tars, Respiratory burst, Enzyme, medicine.anatomical_structure, Biochemistry, Chemistry (miscellaneous), Luminescent Measurements, Filtration, Respiratory tract
Abstract

Cigarette smoking is known to be a risk factor for several chronic and neoplastic diseases. Many compounds formed by cigarette burning, ranging from particulate materials to water solutes and gaseous extracts, are considered to be noxious agents, and many biochemical and molecular mechanisms have been proposed for the toxic effects of cigarette smoke. The oral cavity and the upper respiratory tract represent the first contact areas for smoke compounds; even a single cigarette can produce marked effects on some components of the oral cavity, either chemical compounds, such as glutathione and enzymes, or cellular elements, such as polymorphonuclear leukocytes. Several studies suggest a protective role of glutathione against the noxious effects of tobacco smoke; the sulphydril groups of glutathione, in fact, could react with some smoke products, such as unsaturated aldehydes, leading to the formation of harmless intermediate compounds and simultaneously preventing the inactivation of metabolically essential molecules, such as some enzymes. In this paper we analyse the effect of a filter containing glutathione on the respiratory burst of polymorphonuclear leukocytes exposed to aqueous extract of cigarette smoke, measuring their chemiluminescence activity. The results of this paper indicate that the GSH-containing filter has a likely protective effect against the inhibition of cigarette smoke extract on polymorphonuclear leukocyte activity.

Published
2005

122. Transient state kinetic investigation of ferritin iron release

Author

Ciasca, G., Papi, Massimiliano, Chiarpotto, M., Rodio, M., Campi, G., Rossi, C., De Sole, P., Bianconi, A., Ciasca, G. (ORCID:0000-0002-3694-8229), Papi, Massimiliano (ORCID:0000-0002-0029-1309), Ciasca, G., Papi, Massimiliano, Chiarpotto, M., Rodio, M., Campi, G., Rossi, C., De Sole, P., Bianconi, A., Ciasca, G. (ORCID:0000-0002-3694-8229), and Papi, Massimiliano (ORCID:0000-0002-0029-1309)

Abstract

Increased iron concentration in tissues appears to be a factor in the genesis and development of inflammatory and degenerative diseases. By means of real-time small angle x-ray scattering measurements, we studied the kinetics of iron release from the ferritin inorganic core as a function of time and distance from the iron core centre. Accordingly, the iron release process follows a three step model: (i) a defect nucleation in the outer part of the mineral core, (ii) the diffusion of the reducing agent towards the inner part of the core, and (iii) the erosion of the core from the inner to the outer part.

Published
2012

144. High homocystein levels in inflammatory bowel disease

Author

Papa, A., primary, Danese, S., additional, Persichilli, S., additional, Zappacosta, B., additional, Candelli, M., additional, Minucci, A., additional, Nista, E., additional, Di Caro, S., additional, Padalino, C., additional, De Sole, P., additional, Gasbarrini, G., additional, and Gasbarrini, A., additional

Published
2000
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results