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102. Single Extracellular VEsicle Nanoscopy

Author

Saftics, Andras, primary, Abuelreich, Sarah, additional, Romano, Eugenia, additional, Ghaeli, Ima, additional, Jiang, Nan, additional, Spanos, Michail, additional, Lennon, Kathleen M., additional, Singh, Gagandeep, additional, Das, Saumya, additional, Van Keuren‐Jensen, Kendall, additional, and Jovanovic‐Talisman, Tijana, additional

Published
2023
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104. List of Contributors

Author

Ahmed, Syed Anees, primary, Alkahtani, Saad, additional, Ansari, Mohammed Tahir, additional, Barik, Harekrushna, additional, Behera, Anindita, additional, Bera, Hriday, additional, Chakraborty, Sudipta, additional, Chowdhury, Sailee, additional, Das, Saumya, additional, Dey, Sanjay, additional, Dhara, Amal Kumar, additional, Hasnain, Md Saquib, additional, Hoda, Mohammad Niyaz, additional, Jameel, Ehtesham, additional, Javed, Md Noushad, additional, Kiran, Vema, additional, Kurakula, Mallesh, additional, Maity, Mala, additional, Mohanta, Bibhash Chandra, additional, Mohanta, Bulu, additional, Nanda, Sitansu Sekhar, additional, Nayak, Amit Kumar, additional, Pattanayak, Dharmajit, additional, Rao, GSN Koteswara, additional, Ray, Priyanka, additional, Roy, Susanta, additional, Sahoo, Girija Sankar, additional, Sami, Farheen, additional, Singh, Helvinder Kaur Balbir, additional, Tabish, Mohammad, additional, Tripathi, Garima, additional, and Yi, Dong Kee, additional

Published
2020
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110. Mir-30d Regulates Cardiac Remodeling by Intracellular and Paracrine Signaling

Author

Li, Jin, Salvador, Ane M., Li, Guoping, Valkov, Nedyalka, Ziegler, Olivia, Yeri, Ashish, Yang Xiao, Chun, Meechoovet, Bessie, Alsop, Eric, Rodosthenous, Rodosthenis S., Kundu, Piyusha, Huan, Tianxiao, Levy, Daniel, Tigges, John, Pico, Alexander R., Ghiran, Ionita, Silverman, Michael G., Meng, Xiangmin, Kitchen, Robert, Xu, Jiahong, Van Keuren-Jensen, Kendall, Shah, Ravi, Xiao, Junjie, and Das, Saumya

Published
2021
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113. Exomap1 mouse: a transgenic model for in vivo studies of exosome biology

Author

Fordjour, Francis K., primary, Abuelreich, Sarah, additional, Hong, Xiaoman, additional, Chatterjee, Emeli, additional, Lallai, Valeria, additional, Ng, Martin, additional, Saftics, Andras, additional, Deng, Fengyan, additional, Carnel-Amar, Natacha, additional, Wakimoto, Hiroaki, additional, Shimizu, Kazuhide, additional, Anh Phu, Tuan, additional, Vu, Ngan K, additional, Geiger, Paige C., additional, Raffai, Robert L., additional, Fowler, Christie Dawn, additional, Das, Saumya, additional, Christenson, Lane K., additional, Jovanovic-Talisman, Tijana, additional, and Gould, Stephen, additional

Published
2023
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114. Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Author

Giannetti, Federica, primary, Barbieri, Miriam, additional, Shiti, Assad, additional, Casini, Simona, additional, Sager, Philip T, additional, Das, Saumya, additional, Pradhananga, Sabindra, additional, Srinivasan, Dinesh, additional, Nimani, Saranda, additional, Alerni, Nicolò, additional, Louradour, Julien, additional, Mura, Manuela, additional, Gnecchi, Massimiliano, additional, Brink, Paul, additional, Zehender, Manfred, additional, Koren, Gideon, additional, Zaza, Antonio, additional, Crotti, Lia, additional, Wilde, Arthur A M, additional, Schwartz, Peter J, additional, Remme, Carol Ann, additional, Gepstein, Lior, additional, Sala, Luca, additional, and Odening, Katja E, additional

Published
2023
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119. CITED4 Protects Against Adverse Remodeling in Response to Physiological and Pathological Stress

Author

Lerchenmüller, Carolin, Rabolli, Charles P., Yeri, Ashish, Kitchen, Robert, Salvador, Ane M., Liu, Laura X., Ziegler, Olivia, Danielson, Kirsty, Platt, Colin, Shah, Ravi, Damilano, Federico, Kundu, Piyusha, Riechert, Eva, Katus, Hugo A., Saffitz, Jeffrey E., Keshishian, Hasmik, Carr, Steven A., Bezzerides, Vassilios J., Das, Saumya, and Rosenzweig, Anthony

Published
2020
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120. Gene- and variant-specific efficacy of serum/glucocorticoid-regulated kinase 1 inhibition in long QT syndrome types 1 and 2

Author

Giannetti, Federica, Barbieri, Miriam, Shiti, Assad, Casini, Simona, Sager, Philip T, Das, Saumya, Pradhananga, Sabindra, Srinivasan, Dinesh, Nimani, Saranda, Alerni, Nicolò, Louradour, Julien, Mura, Manuela, Gnecchi, Massimiliano, Brink, Paul, Zehender, Manfred, Koren, Gideon, Zaza, Antonio, Crotti, Lia, Wilde, Arthur A M, Schwartz, Peter J, Remme, Carol Ann, Gepstein, Lior, Sala, Luca, Odening, Katja E, Giannetti, F, Barbieri, M, Shiti, A, Casini, S, Sager, P, Das, S, Pradhananga, S, Srinivasan, D, Nimani, S, Alerni, N, Louradour, J, Mura, M, Gnecchi, M, Brink, P, Zehender, M, Koren, G, Zaza, A, Crotti, L, Wilde, A, Schwartz, P, Remme, C, Gepstein, L, Sala, L, and Odening, K

Subjects
Cellular electrophysiology, Physiology (medical), LQTS, Animal model, 610 Medicine & health, 610 Medizin und Gesundheit, Cardiology and Cardiovascular Medicine, Genotype-specific therapy, hiPSC, Mechanism-based therapy
Abstract

Aims Current long QT syndrome (LQTS) therapy, largely based on beta-blockade, does not prevent arrhythmias in all patients; therefore, novel therapies are warranted. Pharmacological inhibition of the serum/glucocorticoid-regulated kinase 1 (SGK1-Inh) has been shown to shorten action potential duration (APD) in LQTS type 3. We aimed to investigate whether SGK1-Inh could similarly shorten APD in LQTS types 1 and 2. Methods and results Human-induced pluripotent stem cell-derived cardiomyocytes (hiPSC-CMs) and hiPSC-cardiac cell sheets (CCS) were obtained from LQT1 and LQT2 patients; CMs were isolated from transgenic LQT1, LQT2, and wild-type (WT) rabbits. Serum/glucocorticoid-regulated kinase 1 inhibition effects (300 nM–10 µM) on field potential durations (FPD) were investigated in hiPSC-CMs with multielectrode arrays; optical mapping was performed in LQT2 CCS. Whole-cell and perforated patch clamp recordings were performed in isolated LQT1, LQT2, and WT rabbit CMs to investigate SGK1-Inh (3 µM) effects on APD. In all LQT2 models across different species (hiPSC-CMs, hiPSC-CCS, and rabbit CMs) and independent of the disease-causing variant (KCNH2-p.A561V/p.A614V/p.G628S/IVS9-28A/G), SGK1-Inh dose-dependently shortened FPD/APD at 0.3–10 µM (by 20–32%/25–30%/44–45%). Importantly, in LQT2 rabbit CMs, 3 µM SGK1-Inh normalized APD to its WT value. A significant FPD shortening was observed in KCNQ1-p.R594Q hiPSC-CMs at 1/3/10 µM (by 19/26/35%) and in KCNQ1-p.A341V hiPSC-CMs at 10 µM (by 29%). No SGK1-Inh-induced FPD/APD shortening effect was observed in LQT1 KCNQ1-p.A341V hiPSC-CMs or KCNQ1-p.Y315S rabbit CMs at 0.3–3 µM. Conclusion A robust SGK1-Inh-induced APD shortening was observed across different LQT2 models, species, and genetic variants but less consistently in LQT1 models. This suggests a genotype- and variant-specific beneficial effect of this novel therapeutic approach in LQTS.

Published
2023

122. Improving sudden cardiac death risk stratification by evaluating electrocardiographic measures of global electrical heterogeneity and clinical outcomes among patients with implantable cardioverter-defibrillators: rationale and design for a retrospective, multicenter, cohort study

Author

Waks, Jonathan W., Hamilton, Christopher, Das, Saumya, Ehdaie, Ashkan, Minnier, Jessica, Narayan, Sanjiv, Niebauer, Mark, Raitt, Merritt, Tompkins, Christine, Varma, Niraj, Chugh, Sumeet, and Tereshchenko, Larisa G.

Published
2018
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127. Plasma extracellular vesicle transcriptome as a dynamic liquid biopsy in acute heart failure

Author

Gokulnath, Priyanka, primary, Spanos, Michail, additional, Lehmann, H. Immo, additional, Sheng, Quanhu, additional, Rodosthenous, Rodosthenis, additional, Chaffin, Mark, additional, Varrias, Dimitrios, additional, Chatterjee, Emeli, additional, Hutchins, Elizabeth, additional, Li, Guoping, additional, Daaboul, George, additional, Rana, Farhan, additional, Wang, Ashley Mingyi, additional, Van Keuren-Jensen, Kendall, additional, Ellinor, Patrick T., additional, Shah, Ravi, additional, and Das, Saumya, additional

Published
2023
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128. Circulating Extracellular Vesicles in Human Cardiorenal Syndrome Promote Renal Injury

Author

Chatterjee, Emeli, primary, Rodosthenous, Rodosthenis S, additional, Kujala, Ville, additional, Karalis, Katia, additional, Spanos, Michail, additional, Lehmann, Helge Immo, additional, Oliveira, Getulio Oliveira Pereira de, additional, Shi, Mingjian, additional, Fleming, Tyne W Miller, additional, Li, Guoping, additional, Gokulnath, Priyanka, additional, Ghiran, Ionita Calin, additional, Lindenfeld, JoAnn, additional, Mosley, Jonathan D, additional, Sheng, Quanhu, additional, Shah, Ravi, additional, and Das, Saumya, additional

Published
2023
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129. The impact of government policies, funding, and networking to accelerate transatlantic cardiovascular research.

Author

Acharya, Shubhra, Das, Saumya, Devaux, Yvan, and Robinson, Emma L

Subjects
GOVERNMENT policy, CARDIOVASCULAR diseases
Abstract

This article discusses the importance of networking and collaboration in cardiovascular research, particularly between researchers in the United States and Europe. The authors highlight the impact of government policies and funding on research progress and emphasize the need for international partnerships and capacity building. They also acknowledge the challenges associated with international collaborations, such as communication gaps, regional requirements, and privacy concerns. Despite these challenges, the article presents examples of successful international research projects and emphasizes the role of government initiatives and funding agencies in facilitating collaborative projects. The authors call for the expansion of funding programs to include countries with less developed economies and encourage the involvement of pharmaceutical companies and industries in transatlantic research. They conclude by advocating for the refinement and implementation of policies that support modern technology, interdisciplinary research, and open science to foster inclusivity and knowledge sharing among researchers. [Extracted from the article]

Published
2024
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133. Isolation of Extracellular RNA from Serum/Plasma

Author

Filant, Justyna, primary, Nejad, Parham, additional, Paul, Anu, additional, Simonson, Bridget, additional, Srinivasan, Srimeenakshi, additional, Zhang, Xuan, additional, Balaj, Leonora, additional, Das, Saumya, additional, Gandhi, Roopali, additional, Laurent, Louise C., additional, and Sood, Anil K., additional

Published
2018
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135. Central neuromodulators in mitigating functional gastrointestinal disorders: Mechanism and Effectiveness.

Author

Kumari, Soni, Das, Saumya, and Mishra, Apporva

Subjects
*SEROTONIN uptake inhibitors, *ANTIDEPRESSANTS, *TRICYCLIC antidepressants, *CENTRAL nervous system, *GUT microbiome, *MENTAL illness
Abstract

In Functional gastrointestinal disorders, there is a paucity of knowledge regarding the fundamental physical and chemical anomalies, thus it can be solely diagnosed by symptomatology. They are triggered by gastrointestinal problems like changes in gut permeability, propulsion, gut flora, immunological response, and central nervous system function. The patient's nonadaptive behaviors, anxiety and concurrent psychiatric disorders all make these symptoms worse and result in long-lasting symptoms that affect the entire gut, such as discomfort, indigestion, and disturbed bowel habits. A biopsychosocial approach to management entails dietary and nutritional adjustments, modifications in lifestyle recommendations, and the use of medicine to address underlying pathophysiology. Functional gastrointestinal disorders are treated with antidepressants, antipsychotics and various medications that target the central nervous system. These drugs are now referred to as neuromodulators. Patients may benefit from using tricyclic antidepressants, selective serotonin reuptake inhibitors, and various central neuromodulators, but there are also risks involved. The different approaches to treat functional gastrointestinal problems are described in this review paper. The various negative effects of central neuromodulators as well as the processes by which they operate, the distinctions between the various classes and types of agents, and how they differ from one another are discussed in this paper. [ABSTRACT FROM AUTHOR]

Published
2023
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136. Recent advances in hydrogel-based drug delivery for wound healing therapy: A Systematic Review.

Author

Aishwaray, Das, Saumya, Mazumder, Avijit, and Gajender

Subjects
*WOUND healing, *POLYMER networks, *HYALURONIC acid, *ALGINIC acid, *CELL growth, *HYDROGELS
Abstract

A network of hydrophilic polymers makes the hydrogels, polymeric substances with a high water absorption and retention capacity. These materials are advantageous in many biomedical uses, including wound healing. The medicinal potential of multiple hydrogel for wound healing is explained in this review. Alginate, chitosan and hyaluronic acid are 3 types of hydrogels, these were combined to prepare the multiple hydrogel formulation. Alginate can collect much wound exudate, whereas, chitosan is antibacterial and encourage cell growth. Whereas, hyaluronic acid aid in tissue repair. Wound healing involves four perfectly synchronized processes (hemostasis, inflammation, proliferation, and remodeling). For successfully healing of wounds, these four steps need to take place in the right order and timeframe. To heal the wound and prevent secondary infections, the appropriate wound dressing is crucial. There are numerous formulations, where hydrogel is most suitable and frequently used presently, due to its anti-inflammatory, microbiological and easily accessible qualities. [ABSTRACT FROM AUTHOR]

Published
2023
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137. Amelioration of ulcerative colitis by herbal secondary plant metabolites and their molecular mechanism.

Author

Chandel, Shobhini, Das, Saumya, Neha, and Chauhan, Vijayant Singh

Subjects
*ULCERATIVE colitis, *INFLAMMATORY bowel diseases, *CROHN'S disease, *METABOLITES, *HERBAL medicine, *MESALAMINE, *PLANT metabolites
Abstract

Inflammatory bowel diseases (IBDs) are immune-mediated abnormalities of the gastrointestinal tract and primarily include ulcerative colitis (UC) and Crohn's disease (CD). Environmental and genetic variables are part of the disease's etiology. Antibiotics, steroids, amino-salicylate and immunomodulators have all been used to decrease the signs of illness and maintain the recovery. Unfortunately, it has been discovered that prolonged use of these medicines causes serious toxicities, which discourages consumers. The anti-UC campaigns are primarily targeted at oxidative stress or inflammation, which increases the anti-inflammatory cytokine levels and suppresses the pro-inflammatory cytokine levels. Herbal medicines may have advantages due to their high patient acceptance, efficacy, relative safety and low cost. Numerous studies have shown the usefulness of herbal medicines in treating UC and these have achieved widespread patient approval. The research on herbal therapy is insufficient, complicated and perplexing and it is unquestionably linked to both hazards and benefits. To increase the quality and safety of herbal medicine treatments for UC, more carefully controlled clinical trials are required. [ABSTRACT FROM AUTHOR]

Published
2023
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141. Genetic inhibition of serum glucocorticoid kinase 1 prevents obesity-related atrial fibrillation

Author

Bapat, Aneesh, primary, Li, Guoping, additional, Xiao, Ling, additional, Yeri, Ashish, additional, Hulsmans, Maarten, additional, Grune, Jana, additional, Yamazoe, Masahiro, additional, Schloss, Maximilian J., additional, Iwamoto, Yoshiko, additional, Tedeschi, Justin, additional, Yang, Xinyu, additional, Nahrendorf, Matthias, additional, Rosenzweig, Anthony, additional, Ellinor, Patrick T., additional, Das, Saumya, additional, and Milan, David, additional

Published
2022
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142. Heart Failure Strategically Focused Research Network: Summary of Results and Future Directions

Author

Felker, G.Michael, primary, Buttrick, Peter, additional, Rosenzweig, Anthony, additional, Abel, E. Dale, additional, Allen, Larry A., additional, Bristow, Michael, additional, Das, Saumya, additional, DeVore, Adam D., additional, Drakos, Stavros G., additional, Fang, James C., additional, Freedman, Jane E., additional, Hernandez, Adrian F., additional, Li, Dean Y., additional, McKinsey, Timothy A., additional, Newton‐Cheh, Christopher, additional, Rogers, Joseph G., additional, Shah, Ravi V., additional, Shah, Svati H., additional, Stehlik, Josef, additional, and Selzman, Craig H., additional

Published
2022
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145. Immune thrombocytopenia

Author

Mazumder, Avijit, primary, Das, Saumya, additional, Atri, Ayush, additional, Singh, Komal, additional, and Singh, Madhvi, additional

Published
2022
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147. Cardiac troponin T in extracellular vesicles as a novel biomarker in human cardiovascular disease

Author

Lennon, Kathleen M., primary, Saftics, Andras, additional, Abuelreich, Sarah, additional, Sahu, Parul, additional, Lehmann, H. Immo, additional, Maddox, Adam L., additional, Bagabas, Reem, additional, Januzzi, James L., additional, Van Keuren‐Jensen, Kendall, additional, Shah, Ravi, additional, Das, Saumya, additional, and Jovanovic‐Talisman, Tijana, additional

Published
2022
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149. An additional patient withSMAD4‐ Juvenile Polyposis‐Hereditaryhemorrhagic telangiectasia and connective tissue abnormalities:SMAD4loss‐of‐function and gain‐of‐function pathogenic variants result in contrasting phenotypes

Author

Gheewalla, Gregory M., primary, Luther, Jay, additional, Das, Saumya, additional, Kreher, Jeffrey B., additional, Scimone, Eleanor R., additional, Wong, Ashley W., additional, Lindsay, Mark E., additional, and Lin, Angela E., additional

Published
2022
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150. Sex-Specific Differences in Ventricular Remodeling and Response After Cardiac Resynchronization Therapy

Author

Varrias, Dimitrios, primary, De La Hoz, Miguel Armengol, additional, Zhao, Megan, additional, Pujol, Margarida, additional, Orencole, Mary, additional, Venkata, Vikramaditya Samala, additional, Zordok, Magdi Atef, additional, Luong, Katherine, additional, Rana, Farhan, additional, Lau, Emily, additional, Ibrahim, Nasrein, additional, Newton-Cheh, Christopher, additional, Heist, Kevin, additional, Singh, Jagmeet, additional, and Das, Saumya, additional

Published
2022
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