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508 results on '"Darras, Veerle M."'

101. Low Temperature-Induced Circulating Triiodothyronine Accelerates Seasonal Testicular Regression

Author

Ikegami, Keisuke, primary, Atsumi, Yusuke, primary, Yorinaga, Eriko, primary, Ono, Hiroko, primary, Murayama, Itaru, primary, Nakane, Yusuke, primary, Ota, Wataru, primary, Arai, Natsumi, primary, Tega, Akinori, primary, Iigo, Masayuki, primary, Darras, Veerle M., primary, Tsutsui, Kazuyoshi, primary, Hayashi, Yoshitaka, primary, Yoshida, Shosei, primary, and Yoshimura, Takashi, primary

Published
2014
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109. Monocarboxylate Transporter 8 Modulates the Viability and Invasive Capacity of Human Placental Cells and Fetoplacental Growth in Mice

Author

Vasilopoulou, Elisavet, primary, Loubière, Laurence S., additional, Heuer, Heike, additional, Trajkovic-Arsic, Marija, additional, Darras, Veerle M., additional, Visser, Theo J., additional, Lash, Gendie E., additional, Whitley, Guy S., additional, McCabe, Christopher J., additional, Franklyn, Jayne A., additional, Kilby, Mark D., additional, and Chan, Shiao Y., additional

Published
2013
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114. Age-Dependent Changes of Monocarboxylate Transporter 8 Availability in the Postnatal Murine Retina.

Author

Yoshiyuki Henning, Szafranski, Karol, Darras, Veerle M., and Brockerhoff, Susan E.

Subjects
THYROID hormones, TRIIODOTHYRONINE, RETINAL diseases, MONOCARBOXYLATE transporters, CENTRAL nervous system
Abstract

The thyroid hormones (TH) triiodothyronine (T3) and its prohormone thyroxine (T4) are crucial for retinal development and function, and increasing evidence points at TH dysregulation as a cause for retinal degenerative diseases. Thus, precise regulation of retinal TH supply is required for proper retinal function, but knowledge on these mechanisms is still fragmentary. Several transmembrane transporters have been described as key regulators of TH availability in target tissues of which the monocarboxylate transporter 8 (MCT8), a high affinity transporter for T4 and T3, plays an essential role in the central nervous system. Moreover, in the embryonic chicken retina, MCT8 is highly expressed, but the postnatal availability of MCT8 in the mammalian retina was not reported to date. In the present study, spatiotemporal retinal MCT8 availability was examined in mice of different age. For this purpose, we quantified expression levels of Mct8 via Real-Time Reverse-Transcriptase PCR in mouse eyecups (C57BL/6) of juvenile and adult age groups. Additionally, age-dependent MCT8 protein levels were quantified via Western blotting and localized via immunofluorescence confocal microscopy. While no difference in Mct8 expression levels could be detected between age groups, MCT8 protein levels in juvenile animals were about two times higher than in adult animals based on Western blot analyses. Immunohistochemical analyses showed that MCT8 immunoreactivity in the eyecup was restricted to the retina and the retinal pigment epithelium. In juvenile mice, MCT8 was broadly observed along the apical membrane of the retinal pigment epithelium, tightly surrounding photoreceptor outer segments. Distinct immunopositive staining was also detected in the inner nuclear layer and the ganglion cell layer. However, in adult specimens, immunoreactivity visibly declined in all layers, which was in line with Western blot analyses. Since MCT8 was abundantly present in juvenile and about twofold lower in adult retinae, our findings suggest a pivotal role of MCT8 especially during postnatal maturation. The present study provides novel insights into age-dependent retinal TH supply, which might help to understand different aspects regarding retinal development, function, and disorders. [ABSTRACT FROM AUTHOR]

Published
2016
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115. Experimental manipulation of food availability leads to short-term intra-clutch adjustment in egg mass but not in yolk androgen or thyroid hormones.

Author

Ruuskanen, Suvi, Darras, Veerle M., Vries, Bonnie, Visser, Marcel E., and Groothuis, Ton G. G.

Subjects
*BIOAVAILABILITY, *ANDROGENS, *THYROID hormones, *CELLULAR signal transduction, *PHYSIOLOGICAL control systems
Abstract

In birds, mothers can affect their offspring's phenotype and thereby survival via egg composition. It is not well known to what extent and time-scales environmental variation in resource availability, either via resource constrains or adaptive adjustment to predicted rearing conditions, influences maternal effects. We experimentally studied whether egg and yolk mass and yolk hormone levels respond to short-term changes in food availability during laying in wild great tits Parus major. Our treatment groups were: 1) food supplementation (mealworms) from the 1st until the last egg; 2) food supplementation from the 1st until the 5th egg, where the effect of cessation of the supplementary food treatment could also be studied; 3) no food supplementation (controls). We analysed both nutritional resources (egg, yolk and albumen mass), and the important developmental signals, yolk androgens (testosterone and androstenedione), and for the first time in a wild population, yolk thyroid hormones (thyroxine and 3,5,3′-triiodothyronine). Egg mass is a costly resource for females, androgens most likely non-costly signals, whereas thyroid hormones may be costly signals, requiring environmental iodine. In the food supplemented group egg, yolk and albumen mass increased rapidly relative to controls and when food supplementation was halted, egg and albumen mass decreased, indicating rapid responses to resource availability. Yolk androgen and thyroid hormone levels were not affected by food supplementation during laying. Thyroxine showed an increase over the laying sequence and its biological meaning needs further study. The rapid changes in egg mass to variation in within-clutch food availability suggest energetic/protein/nutrient constrains on egg formation. The lack of a response in yolk hormones suggest that perhaps in this species the short-term changes in resource availability during egg laying do not predict offspring rearing conditions, or (for thyroid hormones) do not cause systemic changes in circulating hormones, and hence do not affect maternal signaling. [ABSTRACT FROM AUTHOR]

Published
2016
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