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614 results on '"Dargazanli, Cyril"'

101. Effect of intravenous thrombolysis before endovascular therapy on outcome according to collateral status: insight from the ETIS Registry.

Author

Anadani, Mohammad, Januel, Anne-Christine, Finitsis, Stephanos, Clarençon, Frédéric, Richard, Sébastien, Marnat, Gaultier, Bourcier, Romain, Sibon, Igor, Dargazanli, Cyril, Arquizan, Caroline, Blanc, Raphael, Lapergue, Bertrand, Consoli, Arturo, Eugene, Francois, Vannier, Stephane, Caroff, Jildaz, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, and Rouchaud, Aymeric

Subjects
EVALUATION of medical care, REPORTING of diseases, INTRAVENOUS therapy, CONFIDENCE intervals, COLLATERAL circulation, THROMBOLYTIC therapy, ENDOVASCULAR surgery, ODDS ratio, PATIENT safety, LONGITUDINAL method
Abstract

Background It is unknown whether collateral status modifies the effect of pretreatment intravenous thrombolysis (IVT) on the outcomes of patients with large vessel occlusions treated with endovascular therapy (EVT). We aimed to assess whether collateral status modifies the effect of IVT on the outcomes of EVT in clinical practice. Methods We used data from the ongoing prospective multicentric Endovascular Treatment in Ischemic Stroke (ETIS) Registry in France. Patients with anterior circulation proximal large vessel occlusions treated with EVT within 6 hours of symptom onset were enrolled. Patients were divided into two groups based on pretreatment with IVT. The two groups were matched based on baseline characteristics. We tested the interaction between collateral status and IVT in unadjusted and adjusted models. Results A total of 1589 patients were enrolled in the study, of whom 55% received IVT. Using a propensity score matching method, 724 no IVT patients were matched to 549 IVT patients. In propensity score weighted analysis, IVT was associated with higher odds of early neurological improvement (OR 1.74; 95% CI 1.33 to 2.26), favorable functional outcome (OR 1.66; 95% CI 1.23 to 2.24), excellent functional outcome (OR 2.04; 95% CI 1.47 to 2.83), and successful reperfusion (OR 2.18; 95% CI 1.51 to 3.16). IVT was not associated with mortality or hemorrhagic complications. There was no interaction between collateral status and IVT association with any of the outcomes. Conclusions Collateral status does not modify the effect of pretreatment IVT on the efficacy and safety outcomes of EVT. [ABSTRACT FROM AUTHOR]

Published
2023
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102. Frontline thrombectomy strategy and outcome in acute basilar artery occlusion.

Author

Abdelrady, Mohamed, Ognard, Julien, Cagnazzo, Federico, Derraz, Imad, Lefevre, Pierre-Henri, Riquelme, Carlos, Gascou, Gregory, Arquizan, Caroline, Dargazanli, Cyril, El Aouni, Mourad Cheddad, Salem, Douraied Ben, Mourand, Isabelle, Costalat, Vincent, and Gentric, Jean Christophe

Subjects
ARTERIAL occlusions, SAFETY, CONFIDENCE intervals, REVASCULARIZATION (Surgery), CEREBRAL infarction, INTRACRANIAL hemorrhage, MAGNETIC resonance imaging, BASILAR artery, TREATMENT effectiveness, COMPARATIVE studies, FUNCTIONAL assessment, THROMBECTOMY, DESCRIPTIVE statistics, ODDS ratio
Abstract

Background Novel thrombectomy strategies emanate expeditiously day-by-day counting on access system, clot retriever device, proximity to and integration with the thrombus, and microcatheter disengagement. Nonetheless, the relationship between native thrombectomy strategies and revascularization success remains to be evaluated in basilar artery occlusion (BAO). Purpose To compare the safety and efficacy profile of key frontline thrombectomy strategies in BAO. Methods Retrospective analyses of prospectively maintained stroke registries at two comprehensive stroke centers were performed between January 2015 and December 2019. Patients with BAO selected after MR imaging were categorized into three groups based on the frontline thrombectomy strategy (contact aspiration (CA), stent retriever (SR), or combined (SR+CA)). Patients who experienced failure of clot retrieval followed by an interchanging strategy were categorized as a fourth (switch) group. Clinicoradiological features and procedural variables were compared. The primary outcome measure was the rate of complete revascularization (modified Thrombolysis in Cerebral Infarction (mTICI) grade 2c-3). Favorable outcome was defined as a 90 day modified Rankin Scale score of 0-2. Results Of 1823 patients, we included 128 (33 underwent CA, 35 SR, 35 SR +CA, and 25 switch techniques). Complete revascularization was achieved in 83/140 (59%) primarily analyzed patients. SR +CA was associated with higher odds of complete revascularization (adjusted OR 3.04, 95% CI 1.077 to 8.593, p=0.04) which was an independent predictor of favorable outcome (adjusted OR 2.73. 95% CI 1.152 to 6.458, p=0.02). No significant differences were observed for symptomatic intracranial hemorrhage, functional outcome, or mortality rate. Conclusion Among BAO patients, the combined technique effectively contributed to complete revascularization that showed a 90 day favorable outcome with an equivalent complication rate after thrombectomy. [ABSTRACT FROM AUTHOR]

Published
2023
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103. Successful WEBectomy during embolization of temporal arteriovenous malformation-associated flow-related basilar aneurysms.

Author

Abdelrady, Mohamed, Dargazanli, Cyril, Derraz, Imad, Cagnazzo, Federico, and Costalat, Vincent

Subjects
*ANEURYSMS, *ENDOVASCULAR surgery, *THERAPEUTIC embolization, *ARTERIOVENOUS malformation, *INJECTORS
Abstract

Objective: Intra-procedural WEB device migration is a scarcely reported complication that necessitates prompt intervention. Case Presentation: Endovascular treatment of two broad necked flow-related aneurysms was planned aided by WEB-SL (Woven EndoBridge-single layer) devices in a 71-year-old female with known left temporal arteriovenous malformation. Inadvertent distal migration occurred while performing a control angiogram with an automated iodine injector. Immediate retrieval was successfully performed using a Solitaire stent-retriever. Conclusion: To our knowledge, we report for the first time the successful retrieval of a distally migrated WEB using a stent-retriever device. [ABSTRACT FROM AUTHOR]

Published
2022
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104. Carotid artery direct access for mechanical thrombectomy: the Carotid Artery Puncture Evaluation (CARE) study.

Author

Dumas, Victor, Kaesmacher, Johannes, Ognard, Julien, Forestier, Geraud, Dargazanli, Cyril, Janot, Kevin, Behme, Daniel, Shotar, Eimad, Chabert, Emmanuel, Velasco, Stephane, Bricout, Nicolas, Hassen, Wagih Ben, Veunac, Louis, Geismar, Maxime, Eugene, Francois, Detraz, Lili, Darcourt, Jean, L'Allinec, Vincent, Eker, Omer F., and Consoli, Arturo

Subjects
SURGICAL complication risk factors, CAROTID artery, CONFIDENCE intervals, ISCHEMIC stroke, ARTERIAL puncture, RETROSPECTIVE studies, TREATMENT effectiveness, RISK assessment, TREATMENT failure, THROMBECTOMY, DESCRIPTIVE statistics, PATIENT safety, EVALUATION
Abstract

Background In acute ischemic stroke due to anterior large vessel occlusion (AIS-LVO), accessing the target occluded vessel for mechanical thrombectomy (MT) is sometimes impossible through the femoral approach. We aimed to evaluate the safety and efficacy of direct carotid artery puncture (DCP) for MT in patients with failed alternative vascular access. Methods We retrospectively analyzed data from 45 stroke centers in France, Switzerland and Germany through two research networks from January 2015 to July 2019. We collected physician-centered data on DCP practices and baseline characteristics, procedural variables and clinical outcome after DCP. Uni- and multivariable models were conducted to assess risk factors for complications. Results From January 2015 to July 2019, 28 149 MT were performed, of which 108 (0.39%) resulted in DCP due to unsuccessful vascular access. After DCP, 77 patients (71.3%) had successful reperfusion (modified Thrombolysis In Cerebral Infarction (mTICI) score ≥2b) and 28 (25.9%) were independent (modified Rankin Scale (mRS) score 0-2) at 3 months. 20 complications (18.5%) attributed to DCP occurred, all of them during or within 1 hour of the procedure. Complications led to extension of the intubation time in the intensive care unit in 7 patients (6.4%) and resulted in death in 3 (2.8%). The absence of use of a hemostatic closure device was associated with a higher complication risk (OR 3.04, 95% CI 1.03 to 8.97; p=0043). Conclusion In this large multicentric study, DCP was scantly performed for vascular access to perform MT (0.39%) in patients with AIS-LVO and had a high rate of complications (18.5%). Our results provide arguments for not closing the cervical access by manual compression after MT. [ABSTRACT FROM AUTHOR]

Published
2022
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105. Effect of Operator's Experience on Proficiency in Mechanical Thrombectomy: A Multicenter Study

Author

François Zhu, Wagih Ben Hassen, Nicolas Bricout, Basile Kerleroux, Kevin Janot, Benjamin Gory, René Anxionnat, Sébastien Richard, Adrien Marchal, Raphael Blanc, Michel Piotin, Arturo Consoli, Denis Trystram, Christine Rodriguez Regent, Jean-Philippe Desilles, David Weisenburger-Lile, Simon Escalard, Denis Herbreteau, Heloise Ifergan, Igor Lima Maldonado, Julien Labreuche, Hilde Henon, Olivier Naggara, Bertrand Lapergue, Grégoire Boulouis, Redjem Hocine, Ciccio Gabriele, Smajda Stanislas, Maier Benjamin, Mazighi Mikael, Obadia Mikael, Sabben Candice, Peres Roxanne, Corabianu Ovide, De Broucker Thomas, Smadja Didier, Alamowitch Sonia, Ille Olivier, Manchon Eric, Garcia Pierre-Yves, Taylor Guillaume, Ben Maacha Malek, Wang Adrien, Evrard Serge, Tchikviladze Maya, Ajili Nadia, Gorza Lucas, Buard Géraldine, Coskun Oguzhan, Di Maria Federico, Rodesh Georges, Zimatore Sergio, Leguen Morgan, Gratieux Julie, Pico Fernando, Rakotoharinandrasana Haja, Tassan Philippe, Poll Roxanna, Marinier Sylvie, Nighoghossian Norbert, Riva Roberto, Eker Omer, Turjman Francis, Derex Laurent, Cho Tae-Hee, Mechtouff Laura, Claire Lukaszewicz Anne, Philippeau Frédéric, Cakmak Serkan, Blanc-Lasserre Karine, Vallet Anne-Evelyne, Marnat Gaultier, Gariel Florent, Barreau Xavier, Berge Jérôme, Menegon Patrice, Sibon Igor, Liegey Sebastien, Olindo Stéphane, Renou Pauline, Sagnier Sharmila, Poli Mathilde, Debruxelles Sabrina, Pangon Nicolas, Bourcier Romain, Detraz Lili, Daumas-Duport Benjamin, Alexandre Pierre-Louis, Roy Monica, Lenoble Cédric, L’allinec Vincent, Girot Jean-Baptiste, Desal Hubert, Bracard Serge, Braun Marc, Derelle Anne-Laure, Tonnelet Romain, Liao Liang, Muszynski Patricio, Schmitt Emmanuelle, Planel Sophie, Humbertjean Lisa, Mione Gioia, Lacour Jean-Christophe, Riou-Comte Nolwenn, Audibert Gérard, Voicu Marcela, Alb Ionel, Reitter Marie, Brezeanu Madalina, Masson Agnès, Tabarna Adriana, Podar Ioana, Macian-Montoro Francisco, Saleme Suzanna, Mounayer Charbel, Rouchaud Aymeric, Costalat Vincent, Arquizan Caroline, Dargazanli Cyril, Gascou Grégory, Lefèvre Pierre-Henri, Derraz Imad, Riquelme Carlos, Gaillard Nicolas, Mourand Isabelle, Corti Lucas, Francois Eugene, Vannier Stéphane, Ferre Jean-Christophe, Raoult Helene, Ronziere Thomas, Lassale Maria, Paya Christophe, Gauvrit Jean-Yves, Tracol Clément, Langnier-Lemercier Sophie, Samson Yves, Rosso Charlotte, Leger Anne, Deltour Sandrine, Clarencon Frederic, Shotar Eimad, Spelle Laurent, Denier Christian, Chassin Olivier, Chalumeau Vanessa, Caroff Jildaz, Venditti Laura, Turc Guillaume, Seners Pierre, Domigo Valérie, Lamy Catherine, Birchenall Julia, Isabel Clothilde, Viguier Alain, Cognard Christophe, Christine Januel Anne, Olivot Jean-Marc, Raposo Nicolas, Bonneville Fabrice, François Albucher Jean, Calviere Lionel, Touze Emmanuel, Barbier Charlotte, Schneckenburger Romain, Boulanger Marion, Cogez Julien, Guettier Sophie, Timsit Serge, Gentric Jean-Christophe, Ognard Julien, Mathias Merrien Francois, Ozkul Wermester Ozlem, Massardier Evelyne, Papagiannaki Chrysanthi, Bourdain Frédéric, Patricia Bernady, Lagoarde-Segot Laurent, Cailliez Hélène, Veunac Louis, Higue David, Wolff Valérie, Pop Raoul, Beaujeux Rémi, Mihoc Dan-Sorin, Manisor Monica, Le Bras Anthony, Evain Sarah, Le Guen Arnaud, Richter Sebastian, Hubrecht Regis, Demasles Stéphanie, Barroso Bruno, Zuber Mathieu, Farhat Wassim, Alias Quentin, Lun François, Stenvenoot Delphine, Heinzlef Olivier, Godon Hardy Sylvie, Bohotin Valentin, and Grimaud Jérôme

Subjects
medicine.medical_specialty, Standard of care, Time Factors, Neuroradiologist, 030204 cardiovascular system & hematology, Brain Ischemia, 03 medical and health sciences, 0302 clinical medicine, Operator (computer programming), Medicine, Humans, Registries, Thrombectomy, Advanced and Specialized Nursing, Surgeons, business.industry, Cerebral infarction, Endovascular Procedures, Cerebral Infarction, medicine.disease, Mechanical thrombectomy, Stroke, Multicenter study, Ischemic stroke, Reperfusion, Physical therapy, Neurology (clinical), Cardiology and Cardiovascular Medicine, business, 030217 neurology & neurosurgery
Abstract

Background and Purpose: We aimed to evaluate among trained interventional neuroradiologist, whether increasing individual experience was associated with an improvement in mechanical thrombectomy (MT) procedural performance metrics. Methods: Individual MT procedural data from 5 centers of the Endovascular Treatment in Ischemic Stroke registry and 2 additional high-volume stroke centers were pooled. Operator experience was defined for each operator as a continuous variable, cumulating the number of MT procedures performed since January 2015, as MT became standard of care or, if later than this date, since the operator started performing mechanical thrombectomies in autonomy. We tested the associations between operator’s experience and procedural metrics. Results: A total of 4516 procedures were included, performed by 36 operators at 7 distinct centers, with a median of 97.5 endovascular treatment procedures per operator (interquartile range, 57–170.2) over the study period. Higher operator’s experience, analyzed as a continuous variable, was associated with a significantly shorter procedural duration (β estimate, −3.98 [95% CI, −5.1 to −2.8]; P P =0.013). Conclusions: In trained interventional neuroradiologists, increasing experience in MT is associated with significantly shorter procedural duration and better reperfusion rates, with a theoretical ceiling effect observed after around 100 procedures. These results may inform future training and practice guidelines to set minimal experience standards before autonomization, and to set-up operators’ recertification processes tailored to individual case volume and prior experience.

Published
2021

106. Predictive value of DWI posterior-circulation lesion volume for 90-day clinical outcome after endovascular treatment of acute basilar artery occlusion: a retrospective single-center study

Author

Mourand, Isabelle, primary, Mahmoudi, Mehdi, additional, Lebars, Emmanuelle, additional, Pavillard, Frederique, additional, Dargazanli, Cyril, additional, Labreuche, Julien, additional, Gaillard, Nicolas, additional, Ter Schiphorst, Adrien, additional, Derraz, Imad, additional, Sablot, Denis, additional, Corti, Lucas, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, and Cagnazzo, Federico, additional

Published
2021
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107. Balloon Guide Catheter is Not Superior to Conventional Guide Catheter when Stent Retriever and Contact Aspiration are Combined for Stroke Treatment

Author

Bourcier, Romain, primary, Marnat, Gaultier, additional, Labreuche, Julien, additional, Desal, Hubert, additional, Maria, Federico Di, additional, Consoli, Arturo, additional, Eugène, François, additional, Gory, Benjamin, additional, Dargazanli, Cyril, additional, Blanc, Raphaël, additional, and Lapergue, Bertrand, additional

Published
2021
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108. Relevance of Brain Regions' Eloquence Assessment in Patients With a Large Ischemic Core Treated With Mechanical Thrombectomy

Author

Kerleroux, Basile, primary, Benzakoun, Joseph, additional, Janot, Kévin, additional, Dargazanli, Cyril, additional, Eraya, Dimitri Daly, additional, Ben Hassen, Wagih, additional, Zhu, François, additional, Gory, Benjamin, additional, Hak, Jean-Francois, additional, Perot, Charline, additional, Detraz, Lili, additional, Bourcier, Romain, additional, Aymeric, Rouchaud, additional, Forestier, Géraud, additional, Marnat, Gaultier, additional, Gariel, Florent, additional, Mordasini, Pasquale, additional, Seners, Pierre, additional, Turc, Guillaume, additional, Kaesmacher, Johannes, additional, Oppenheim, Catherine, additional, Naggara, Olivier, additional, and Boulouis, Gregoire, additional

Published
2021
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110. Association of Hypotension During Thrombectomy and Outcomes Differs With the Posterior Communicating Artery Patency

Author

Maïer, Benjamin, primary, Robichon, Erwan, additional, Bourcier, Romain, additional, Dargazanli, Cyril, additional, Labreuche, Julien, additional, Thion, Laurie-Anne, additional, Leguen, Morgan, additional, Riem, Romuald, additional, Desilles, Jean-Philippe, additional, Boulouis, Grégoire, additional, Delvoye, François, additional, Hebert, Solène, additional, Redjem, Hocine, additional, Smajda, Stanislas, additional, Escalard, Simon, additional, Blanc, Raphaël, additional, Piotin, Michel, additional, Lapergue, Bertrand, additional, Mazighi, Mikael, additional, Fahed, Robert, additional, Maacha, Malek Ben, additional, Rodesch, Georges, additional, Consoli, Arturo, additional, Coskun, Aguzhan, additional, Maria, Federico Di, additional, Bourdain, Frédéric, additional, Decroix, Jean-Pierre, additional, Wang, Adrien, additional, Tchikviladze, Maya, additional, Evrard, Serge, additional, Lopez, Delphine, additional, Turjman, Francis, additional, Gory, Benjamin, additional, Labeyrie, Paul-Emile, additional, Riva, Roberto, additional, Mounayer, Charbel, additional, Saleme, Suzanna, additional, Costalat, Vincent, additional, Bonafé, Alain, additional, Eker, Omer, additional, Gascou, Grégory, additional, Darganzali, Cyril, additional, Bracard, Serge, additional, Tonnelet, Romain, additional, Derelle, Anne Laure, additional, Anxionnat, René, additional, Desal, Hubert, additional, Daumas Duport, Benjamin, additional, Berge, Jérome, additional, Barreau, Xavier, additional, Margnat, Gauthier, additional, Djemmane, Lynda, additional, and Duhamel, Alain, additional

Published
2021
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111. Complete recanalization predicts favorable outcome in patients with distal M2-M3 middle cerebral artery occlusions following endovascular thrombectomy

Author

ABDELRADY, Mohamed, DERRAZ, Imad, DARGAZANLI, Cyril, CHEDDAD EL AOUNI, Mourad, LEFEVRE, Pierre-Henri, CAGNAZZO, Federico, RIQUELME, Carlos, GASCOU, Gregory, ARQUIZAN, Caroline, MOURAND, Isabelle, BEN SALEM, Douraied, COSTALAT, Vincent, GENTRIC, Jean-Christophe, and OGNARD, Julien

Abstract

— scanty articles illustrate the prognostic factors for favorable outcome after endovascular thrombectomy (EVT) in distal vessel occlusion (DMVO). Moreover, the current literature is diversified; conglomerating both primary, secondary, and anterior, posterior circulations embolic strokes in the same shell.

Published
2023
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113. Collateral status reperfusion and outcomes after endovascular therapy: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) Registry

Author

Anadani, Mohammad, primary, Finitsis, Stephanos, additional, Clarençon, Frédéric, additional, Richard, Sébastien, additional, Marnat, Gaultier, additional, Bourcier, Romain, additional, Sibon, Igor, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Blanc, Raphael, additional, Lapergue, Bertrand, additional, Consoli, Arturo, additional, Eugene, Francois, additional, Vannier, Stephane, additional, Spelle, Laurent, additional, Denier, Christian, additional, Boulanger, Marion, additional, Gauberti, Maxime, additional, Liebeskind, David S, additional, de Havenon, Adam, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Rosso, Charlotte, additional, Naggara, Olivier, additional, Turc, Guillaume, additional, Ozkul-Wermester, Ozlem, additional, Papagiannaki, Chrisanthi, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Le Bras, Anthony, additional, Evain, Sarah, additional, Wolff, Valerie, additional, Pop, Raoul, additional, Timsit, Serge, additional, Gentric, Jean-Christophe, additional, Bourdain, Frédéric, additional, Veunac, Louis, additional, Maier, Benjamin, additional, and Gory, Benjamin, additional

Published
2021
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115. Safety and efficacy of the Silk flow diverter: Insight from the DIVERSION prospective cohort study

Author

Gariel, Florent, primary, Marnat, Gaultier, additional, Barreau, Xavier, additional, Menegon, Patrice, additional, Bourcier, Romain, additional, Pierot, Laurent, additional, Spelle, Lauren, additional, Bonafé, Alain, additional, Turjman, Francis, additional, Gory, Benjamin, additional, Berge, Jérôme, additional, Costalat, Vincent, additional, Gascou, Gregory, additional, Dargazanli, Cyril, additional, Soize, Sébastien, additional, Metaxas, Georges, additional, Moret, Jacques, additional, Ikka, Léon, additional, Caroff, Jildaz, additional, Rouchaud, Aymeric, additional, Mihaela, Christian, additional, Benachour, Nidal, additional, Piotin, Michel, additional, Blanc, Raphaël, additional, Redjem, Hocine, additional, Pomero, Elisa, additional, Biondi, Alessandra, additional, Cognard, Christophe, additional, Januel, Anne-Christine, additional, Darcourt, Jean, additional, Guenego, Adrien, additional, Tall, Philippe, additional, Bonneville, Fabrice, additional, Mounayer, Charbel, additional, Saleme, Suzana, additional, Sourour, Nader, additional, Clarençon, Frédéric, additional, Barbier, Charlotte, additional, Herbreteau, Denis, additional, Narata, Ana-Paula, additional, Bibi, Richard, additional, Bracard, Serge, additional, Anxionnat, René, additional, Derelle, Anne-Laure, additional, Tonnelet, Romain, additional, Liao, Liang, additional, Chabert, Emmanuel, additional, Brunel, Hervé, additional, Ricolfi, Frederic, additional, Desal, Hubert, additional, Kulcsar, Zsolt, additional, and Taschner, Christian, additional

Published
2021
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116. Prognosis and risk factors associated with asymptomatic intracranial hemorrhage after endovascular treatment of large vessel occlusion stroke: a prospective multicenter cohort study

Author

Constant Dit Beaufils, Pacôme, Labreuche, Julien, Richard, Śebastien, Fahed, Robert, Desal, Hubert Armand, Piotin, Michel P., Blanc, Raphaël, Redjem, Hocine, Escalard, Simon, Desilles, Jean Philippe, Ciccio, Gabriele, Smajda, Stanislas, Maier, Benjamin, Mazighi, Mikael, Obadia, Mikael, Sabben, Candice, Peres, Roxanne, Corabianu, Ovide, De Broucker, Thomas, Smadja, Didier, Alamowitch, Sonia, Ille, Olivier, Manchon, Eric, Garcia, Pierre Yves, Taylor, Guillaume, Ben Maacha, Malek, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Ajili, Nadia, Lapergue, Bertrand, Weisenburger, David, Gorza, Lucas, Buard, Géraldine, Coskun, Oguzhan, Consoli, Arturo, Di Maria, Federico, Rodesh, Georges, Zimatore, Sergio, Leguen, Morgan, Gratieux, Julie D., Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Marinier, Sylvie, Nighoghossian, Norbert, Riva, Roberto, Eker, Omer faruk, Turjman, Francis, Derex, Laurent, Cho, Tae-Hee, Mechtouff, Laura, Lukaszewicz, Anne Claire, Philippeau, Frédéric, Cakmak, Serkan, Blanc-Lasserre, Karine, Vallet, Anne Evelyne, Marnat, Gaultier, Gariel, Florent, Barreau, Xavier, Berge, Jerome, Veunac, Louis, Menegon, Patrice, Sibon, Igor, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Tourdias, Thomas, Liegey, Jean Sebastien, Bourcier, Romain, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre Louis, Roy, Monica, Lenoble, Cédric, L’Allinec, Vincent, Girot, Jean Baptiste, Desal, Hubert, Guillon, Benoît, De Gaalon, Solène, Preterre, Cécile, Gory, Benjamin, Bracard, Serge R., Anxionnat, René, Braun, Marc, Derelle, Anne Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Richard, Sébastien, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean Christophe, Bonnerot, Mathieu, Riou-Comte, Nolwenn, Macian-Montoro, Francisco, Saleme, Suzanna, Mounayer, Charbel, Rouchaud, Aymeric M., Costalat, Vincent, Arquizan, Caroline, Dargazanli, Cyril, Gascou, Grégory, Lefèvre, Pierre Henri, Derraz, Imad, Riquelme, Carlos, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, Francois, Eugene, Vannier, Stéphane, Ferré, Jean-Christophe, Raoult, Hélène, Ronziere, Thomas, Lassale, Maria, Paya, Christophe, Gauvrit, Jean Yves, Tracol, Clément, Langnier-Lemercier, Sophie, Samson, Yves, Rosso, Charlotte, Leger, Anne, Deltour, Sandrine, Clarencon, Frédéric, Shotar, Eimad, Spelle, Laurent, Denier, Christian, Chalumeau, Vanessa, Caroff, Jildaz, Chassin, Olivier, Venditti, Laura, Turc, G., Naggara, Olivier N., Boulouis, Grégoire, Ben Hassen, Wagih, Seners, Pierre, Viguier, Alain, Cognard, Christophe H., Januel, Anne Christine, Olivot, Jean Marc, Raposo, Nicolas, Bonneville, Fabrice, Touze, Emmanuel, Barbier, Charlotte N., Schneckenburger, Romain, Boulanger, Marion, Cogez, Julien, Guettier, Sophie, Université de Versailles Saint-Quentin-en-Yvelines (UVSQ), Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch], Hôpital Foch [Suresnes], Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), P.C.D.B. and J.L. have nothing to disclose. R. Blanc, R. Bourcier, A.C., H.D., F.D.M., R.F., F.G., B. Gory, G.M., C.P., S.R., I.S. and F.Z. have nothing to disclose. M.M. reports personal fees from Amgen, personal fees from Boerhinger, personal fees from Acticor, and personal fees from Air Liquide, outside the submitted work. B.L. reports grants from Stryker, Penumbra and Microventino, outside the submitted work. S.D.G. reports personal fees and non‐financial support from Boerhinger, outside the submitted work. B. Guillon reports personal fees from Boerhinger‐Ingelheim France and Bristol‐Myers‐Squibb, outside the submitted work., Centre hospitalier universitaire de Nantes (CHU Nantes), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire de Recherche Vasculaire Translationnelle (LVTS (UMR_S_1148 / U1148)), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Cité (UPCité)-Université Sorbonne Paris Nord, Service de neuroradiologie [Suresnes], Service de neurologie [Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Département de Neuro-Radiologie [Bordeaux] (DNR - Bordeaux), CHU Bordeaux [Bordeaux], Service de neurologie [CHRU Nancy], Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), and The Ottawa Hospital

Subjects
Male, endovascular treatment, medicine.medical_specialty, Asymptomatic, Brain Ischemia, Cohort Studies, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Risk Factors, Modified Rankin Scale, Internal medicine, Humans, Medicine, asymptomatic, Registries, 030212 general & internal medicine, Stroke, Thrombectomy, Intracerebral hemorrhage, business.industry, Endovascular Procedures, Odds ratio, medicine.disease, intracerebral hemorrhage, stroke, Confidence interval, 3. Good health, Treatment Outcome, Neurology, Cardiology, [SDV.NEU]Life Sciences [q-bio]/Neurons and Cognition [q-bio.NC], Neurology (clinical), prognosis, medicine.symptom, business, Intracranial Hemorrhages, 030217 neurology & neurosurgery, Cohort study
Abstract

International audience; Background and purpose: Asymptomatic intracranial hemorrhage (aICH) is a common occurrence after endovascular treatment (EVT) for acute ischemic stroke (AIS). The aims of this study were to address its impact on 3-month functional outcome and to identify risk factors for aICH after EVT. Methods: Patients with AIS attributable to anterior circulation large vessel occlusion who underwent EVT were enrolled in a multicenter prospective registry. Based on imaging performed 22–36 h post-EVT, we included patients with no intracranial hemorrhage (ICH) or aICH. Poor outcome defined as a 3-month modified Rankin Scale (mRS) score 4–6 and overall 3-month mRS score distribution were compared according to presence/absence of aICH, and aICH subtype using logistic regression. We assessed the risk factors of aICH using a multivariate logistic regression model. Results: Of the 1526 patients included in the study, 653 (42.7%) had aICH. Patients with aICH had a higher rate of poor outcome: odds ratio (OR) 1.88 (95% confidence interval [CI] 1.44–2.44). Shift analysis of mRS score found a fully adjusted OR of 1.79 (95% CI 1.47–2.18). Hemorrhagic infarction (OR 1.63 [95% CI 1.22–2.18]) and parenchymal hematoma (OR 2.99 [95% CI 1.77–5.02]) were associated with higher risk of poor outcome. Male sex, diabetes, coronary artery disease, baseline National Institutes of Health Stroke Scale score and Alberta Stroke Program Early Computed Tomography Score, number of passes and onset to groin puncture time were independently associated with aICH. Conclusions: Patients with aICH, irrespective of the radiological pattern, have a worse functional outcome at 3 months compared with those without ICH after EVT for AIS. The number of EVT passes and the time from onset to groin puncture are factors that could be modified to reduce deleterious ICH.

Published
2021

117. Safety and Outcome of Carotid Dissection Stenting During the Treatment of Tandem Occlusions: A Pooled Analysis of TITAN and ETIS

Author

Marnat, Gaultier, Lapergue, Bertrand, Sibon, Igor, Gariel, Florent, Bourcier, Romain, Kyheng, Maeva, Labreuche, Julien, Dargazanli, Cyril, Consoli, Arturo, Blanc, Raphael, Piotin, Michel, Mazighi, Mikael, Richard, Sebastien, Gory, Benjamin, Redjem, Hocine, Escalard, Simon, Desilles, Jean-Philippe, Ciccio, Gabriele, Smajda, Stanislas, Fahed, Robert, Obadia, Mikael, Sabben, Candice, Corabianu, Ovide, De Broucker, Thomas, Smadja, Didier, Alamowitch, Sonia, Ille, Olivier, Manchon, Eric, Garcia, Pierre-Yves, Taylor, Guillaume, Ben Maacha, Malek, Bourdain, Frédéric, Decroix, Jean-Pierre, Wang, Adrien, Evrard, Serge, Tchikviladze, Maya, Coskun, Oguzhan, Di Maria, Federico, Rodesh, Georges, Leguen, Morgan, Tisserand, Marie, Pico, Fernando, Rakotoharinandrasana, Haja, Tassan, Philippe, Poll, Roxanna, Nighoghossian, Norbert, Riva, Roberto, Eker, Omer, Turjman, Francis, Derex, Laurent, Cho, Tae-Hee, Mechtouff, Laura, Claire Lukaszewicz, Anne, Philippeau, Frédéric, Cakmak, Serkan, Blanc-Lasserre, Karine, Vallet, Anne-Evelyne, Barreau, Xavier, Berge, Jérôme, Menegon, Patrice, Lucas, Ludovic, Olindo, Stéphane, Renou, Pauline, Sagnier, Sharmila, Poli, Mathilde, Debruxelles, Sabrina, Rouanet, François, Tourdias, Thomas, Liegey, Jean-Sebastien, Detraz, Lili, Daumas-Duport, Benjamin, Alexandre, Pierre-Louis, Roy, Monica, Lenoble, Cédric, L’Allinec, Vincent, Girot, Jean-Baptiste, Desal, Hubert, Bracard, Serge, Anxionnat, René, Braun, Marc, Derelle, Anne-Laure, Tonnelet, Romain, Liao, Liang, Zhu, François, Schmitt, Emmanuelle, Planel, Sophie, Humbertjean, Lisa, Mione, Gioia, Lacour, Jean-Christophe, Bonnerot, Mathieu, Riou-Comte, Nolwenn, Costalat, Vincent, Gascou, Grégory, Lefèvre, Pierre-Henri, Derraz, Imad, Riquelme, Carlos, Arquizan, Caroline, Gaillard, Nicolas, Mourand, Isabelle, Corti, Lucas, Cagnazzo, Federico, Anadani, Mohammad, Spiotta, Alejandro, Alawieh, Ali, Haussen, Diogo, Nogueira, Raul, Papanagiotou, Panagiotis, Siddiqui, Adnan, Dorn, Franziska, Cognard, Christophe, Ribo, Marc, Psychogios, Marios, Labeyrie, Marc Antoine, Biondi, Alessandra, Andrew Grossberg, Jonathan, Guenego, Adrien, Darcourt, Julien, Vukasinovic, Isabelle, Pomero, Elisa, Davies, Jason, Renieri, Leonardo, Hecker, Corentin, Muchada Muchada, Maria, Houdart, Emmanuel, Turner, Raymond, Turk, Aquilla, Chaudry, Imran, Lockau, Johanna, Kastrup, Andreas, Behme, Daniel, Shallwani, Hussain, Christopher, Maurer, Département de Neuro-Radiologie [Bordeaux] (DNR - Bordeaux), CHU Bordeaux [Bordeaux], Hôpital Foch [Suresnes], Service de neurologie [Bordeaux], CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Centre hospitalier universitaire de Nantes (CHU Nantes), Fondation Ophtalmologique Adolphe de Rothschild [Paris], Santé Publique : épidémiologie et qualité des soins (EA 2694), Université Lille 2 - Faculté de Médecine -Centre d'Etudes et de Recherche en Informatique Médicale [Lille] (CERIM), Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Département de Neuroradiologie[Montpellier], Université Montpellier 1 (UM1)-Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Hôpital Gui de Chauliac [Montpellier]-Université de Montpellier (UM), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Université de Lorraine (UL)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de neurologie [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Défaillance Cardiovasculaire Aiguë et Chronique (DCAC), Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), and Université de Montpellier (UM)

Subjects
Male, MESH: Cerebral Hemorrhage, MESH: Cerebral Angiography, carotid dissection, Carotid Artery, Internal, Dissection, 030204 cardiovascular system & hematology, 0302 clinical medicine, MESH: Carotid Stenosis, MESH: Emergencies, Occlusion, Odds Ratio, Carotid Stenosis, Acute ischemic stroke, MESH: Treatment Outcome, MESH: Middle Aged, Cerebral infarction, Endovascular Procedures, MESH: Postoperative Hemorrhage, Middle Aged, cerebral infarction, 3. Good health, reperfusion, Dissection, Treatment Outcome, Pooled analysis, dissection, Female, Stents, Radiology, Internal carotid artery, Carotid dissection, Cardiology and Cardiovascular Medicine, Carotid Artery, Internal, MESH: Ischemic Stroke, Adult, medicine.medical_specialty, MESH: Carotid Artery, Internal, MESH: Endovascular Procedures, internal carotid artery, Postoperative Hemorrhage, MESH: Carotid Artery, Internal, Dissection, 03 medical and health sciences, [SDV.MHEP.CSC]Life Sciences [q-bio]/Human health and pathology/Cardiology and cardiovascular system, medicine.artery, medicine, Humans, In patient, cardiovascular diseases, Mortality, Ischemic Stroke, Retrospective Studies, Advanced and Specialized Nursing, cerebral hemorrhage, MESH: Humans, MESH: Mortality, business.industry, MESH: Adult, MESH: Retrospective Studies, medicine.disease, MESH: Male, MESH: Odds Ratio, Cerebral Angiography, MESH: Stents, Neurology (clinical), Emergencies, business, MESH: Female, 030217 neurology & neurosurgery
Abstract

Background and Purpose: The efficacy of endovascular therapy in patients with acute ischemic stroke due to tandem occlusion is comparable to that for isolated intracranial occlusion in the anterior circulation. However, the optimal management of acute cervical internal carotid artery lesions is unknown, especially in the setting of carotid dissection, but emergency carotid artery stenting (CAS) is frequently considered. We investigated the safety and efficacy of emergency CAS for carotid dissection in patients with acute stroke with tandem occlusion in current clinical practice. Methods: We retrospectively analyzed a prospectively maintained database composed of 2 merged multicenter international observational real-world registries (Endovascular Treatment in Ischemic Stroke and Thrombectomy in Tandem Lesion). Data from endovascular therapy performed in the treatment of tandem occlusions related to acute cervical carotid dissection between January 2012 and January 2019 at 24 comprehensive stroke centers were analyzed. Results: The study assessed 136 patients with tandem occlusion due to dissection, including 65 (47.8%) treated with emergency CAS and 71 (52.2%) without. The overall rates of favorable outcome (90-day modified Rankin Scale score, 0–2) and successful reperfusion (modified Thrombolysis in Cerebral Infarction, 2b–3) were 58.0% (n=76 [95% CI, 49.6%–66.5%]) and 77.9% (n=106 [95% CI, 71.0%–85.0%]), respectively. In subgroup analyses, the rate of successful reperfusion (89.2% versus 67.6%; adjusted odds ratio, 2.24 [95% CI, 1.33–3.77]) was higher after CAS, whereas the 90-day favorable outcome (54.3% versus 61.4%; adjusted odds ratio, 0.84 [95% CI, 0.58–1.22]), symptomatic intracerebral hemorrhage (sICH; 10.8% versus 5.6%; adjusted odds ratio, 1.59 [95% CI, 0.79–3.17]), and 90-day mortality (8.0% versus 5.8%; adjusted odds ratio, 1.00 [95% CI, 0.48–2.09]) did not differ. In sensitivity analyses of patients with successful intracranial reperfusion, CAS was not associated with an improved clinical outcome. Conclusions: Emergency stenting of the dissected cervical carotid artery during endovascular therapy for tandem occlusions seems safe, whatever the quality of the intracranial reperfusion.

Published
2020

118. Endovascular reperfusion of M2 occlusions in acute ischemic stroke reduced disability and mortality: ETIS Registry results

Author

Muszynski, Patricio, primary, Anadani, Mohammad, additional, Richard, Sébastien, additional, Marnat, Gaultier, additional, Bourcier, Romain, additional, Sibon, Igor, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Maïer, Benjamin, additional, Blanc, Raphaël, additional, Lapergue, Bertrand, additional, Consoli, Arturo, additional, Eugene, Francois, additional, Vannier, Stephane, additional, Spelle, Laurent, additional, Denier, Christian, additional, Boulanger, Marion, additional, Gauberti, Maxime, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Clarençon, Frédéric, additional, Rosso, Charlotte, additional, Naggara, Olivier, additional, Turc, Guillaume, additional, Ozkul-Wermester, Ozlem, additional, Papagiannaki, Chrisanthi, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Le Bras, Anthony, additional, Evain, Sarah, additional, Wolff, Valérie, additional, Pop, Raoul, additional, Timsit, Serge, additional, Gentric, Jean-Christophe, additional, Bourdain, Frédéric, additional, Veunac, Louis, additional, Gory, Benjamin, additional, and Finitsis, Stephanos Nikolaos, additional

Published
2021
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119. First-line thrombectomy strategy for anterior large vessel occlusions: results of the prospective ETIS egistry

Author

Maïer, Benjamin, primary, Finitsis, Stephanos, additional, Bourcier, Romain, additional, Papanagiotou, Panagiotis, additional, Richard, Sébastien, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Blanc, Raphael, additional, Piotin, Michel, additional, Lapergue, Bertrand, additional, Consoli, Arturo, additional, Eugene, Francois, additional, Vannier, Stephane, additional, Saleme, Suzana, additional, Macian, Francisco, additional, Clarençon, Frédéric, additional, Rosso, Charlotte, additional, Naggara, Olivier, additional, Turc, Guillaume, additional, Viguier, Alain, additional, Cognard, Christophe, additional, Wolff, Valerie, additional, Pop, Raoul, additional, Mazighi, Mikael, additional, and Gory, Benjamin, additional

Published
2021
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121. Thrombectomy for Basilar Artery Occlusion with Mild Symptoms

Author

Guenego, Adrien, primary, Dargazanli, Cyril, additional, Weisenburger-Lile, David, additional, Gory, Benjamin, additional, Richard, Sébastien, additional, Ducroux, Célina, additional, Piotin, Michel, additional, Blanc, Raphael, additional, Labreuche, Julien, additional, Lucas, Ludovic, additional, Aubertin, Mathilde, additional, Benali, Amel, additional, Bourcier, Romain, additional, Detraz, Lili, additional, Vannier, Stéphane, additional, Guillen, Maud, additional, Eugene, François, additional, Walker, Gregory, additional, Lun, Ronda, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, Fahed, Robert, additional, Redjem, Hocine, additional, Escalard, Simon, additional, Desilles, Jean-Philippe, additional, Ciccio, Gabriele, additional, Smajda, Stanislas, additional, Maier, Benjamin, additional, Hebert, Solene, additional, Delvoye, François, additional, Mazighi, Mikael, additional, Obadia, Mikael, additional, Sabben, Candice, additional, Peres, Roxanne, additional, Corabianu, Ovide, additional, de Broucker, Thomas, additional, Smadja, Didier, additional, Alamowitch, Sonia, additional, Ille, Olivier, additional, Manchon, Eric, additional, Garcia, Pierre-Yves, additional, Taylor, Guillaume, additional, Ben Maacha, Malek, additional, Wang, Adrien, additional, Evrard, Serge, additional, Tchikviladze, Maya, additional, Ajili, Nadia, additional, Weisenburger, David, additional, Gorza, Lucas, additional, Buard, Géraldine, additional, Coskun, Oguzhan, additional, Di Maria, Federico, additional, Rodesh, Georges, additional, Zimatore, Sergio, additional, Leguen, Morgan, additional, Gratieux, Julie, additional, Pico, Fernando, additional, Rakotoharinandrasana, Haja, additional, Tassan, Philippe, additional, Poll, Roxanna, additional, Marinier, Sylvie, additional, Marnat, Gaultier, additional, Gariel, Florent, additional, Barreau, Xavier, additional, Berge, Jérôme, additional, Veunac, Louis, additional, Menegon, Patrice, additional, Sibon, Igor, additional, Olindo, Stéphane, additional, Renou, Pauline, additional, Sagnier, Sharmila, additional, Poli, Mathilde, additional, Debruxelles, Sabrina, additional, Daumas-Duport, Benjamin, additional, Alexandre, Pierre-Louis, additional, Roy, Monica, additional, Lenoble, Cédric, additional, L'allinec, Vincent, additional, Girot, Jean-Baptiste, additional, Desal, Hubert, additional, Bracard, Serge, additional, Anxionnat, René, additional, Braun, Marc, additional, Derelle, Anne-Laure, additional, Tonnelet, Romain, additional, Liao, Liang, additional, Zhu, François, additional, Schmitt, Emmanuelle, additional, Planel, Sophie, additional, Humbertjean, Lisa, additional, Mione, Gioia, additional, Lacour, Jean-Christophe, additional, Bonnerot, Mathieu, additional, Riou-Comte, Nolwenn, additional, Costalat, Vincent, additional, Arquizan, Caroline, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Derraz, Imad, additional, Riquelme, Carlos, additional, Gaillard, Nicolas, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, François, Eugene, additional, Ferre, Jean-Christophe, additional, Raoult, Helene, additional, Ronziere, Thomas, additional, Lassale, Maria, additional, Paya, Christophe, additional, Gauvrit, Jean-Yves, additional, Tracol, Clément, additional, and Langnier-Lemercier, Sophie, additional

Published
2021
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122. Collateral status reperfusion and outcomes after endovascular therapy: insight from the Endovascular Treatment in Ischemic Stroke (ETIS) Registry.

Author

Anadani, Mohammad, Finitsis, Stephanos, Clarençon, Frédéric, Richard, Sébastien, Marnat, Gaultier, Bourcier, Romain, Sibon, Igor, Dargazanli, Cyril, Arquizan, Caroline, Blanc, Raphael, Lapergue, Bertrand, Consoli, Arturo, Eugene, Francois, Vannier, Stephane, Spelle, Laurent, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Liebeskind, David S., and de Havenon, Adam

Subjects
EVALUATION of medical care, CONFIDENCE intervals, COLLATERAL circulation, ENDOVASCULAR surgery, REPERFUSION, ANGIOGRAPHY, ODDS ratio
Abstract

Background Studies have suggested that collateral status modifies the effect of successful reperfusion on functional outcome after endovascular therapy (EVT). We aimed to assess the association between collateral status and EVT outcomes and to investigate whether collateral status modified the effect of successful reperfusion on EVT outcomes. Methods We used data from the ongoing, prospective, multicenter Endovascular Treatment in Ischemic Stroke (ETIS) Registry. Collaterals were graded according to the American Society of Interventional and Therapeutic Neuroradiology/Society of Interventional Radiology (ASITN/SIR) guidelines. Patients were divided into two groups based on angiographic collateral status: poor (grade 0-2) versus good (grade 3-4) collaterals. Results Among 2020 patients included in the study, 959 (47%) had good collaterals. Good collaterals were associated with favorable outcome (90-day modified Rankin Scale (mRS) 0-2) (OR 1.5, 95% CI 1.19 to 1.88). Probability of good outcome decreased with increased time from onset to reperfusion in both good and poor collateral groups. Successful reperfusion was associated with higher odds of favorable outcome in good collaterals (OR 6.01, 95% CI 3.27 to 11.04) and poor collaterals (OR 5.65, 95% CI 3.32 to 9.63) with no significant interaction. Similarly, successful reperfusion was associated with higher odds of excellent outcome (90-day mRS 0-1) and lower odds of mortality in both groups with no significant interaction. The benefit of successful reperfusion decreased with time from onset in both groups, but the curve was steeper in the poor collateral group. Conclusions Collateral status predicted functional outcome after EVT. However, collateral status on the pretreatment angiogram did not decrease the clinical benefit of successful reperfusion. [ABSTRACT FROM AUTHOR]

Published
2022
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124. Abstract P533: Incidence and Outcomes of Thrombectomy Rescue Therapies in Acute Basilar Artery Occlusions

Author

Lun, Ronda, primary, Walker, Greg B, additional, Weisenburger-Lile, David, additional, Lapergue, Bertrand, additional, Guenego, Adrien, additional, heran, navraj s, additional, Siu, William, additional, Dargazanli, Cyril, additional, Benali, Amel, additional, Gory, Benjamin, additional, Richard, Sebastien, additional, Ducroux, Celina, additional, Piotin, Michel, additional, BLANC, RAPHAEL, additional, Labreuche, Julien, additional, Lucas, Ludovic, additional, Haddad, John, additional, Aubertin, Mathilde, additional, vannier, stephane, additional, Guillen, Maud, additional, Eugene, Francois, additional, Maier, Benjamin, additional, Marnat, Gaultier, additional, Detraz, Lili, additional, Bourcier, Romain, additional, and FAHED, Robert, additional

Published
2021
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125. Mechanical Thrombectomy for Acute Ischemic Stroke Amid the COVID-19 Outbreak

Author

Kerleroux, Basile, Fabacher, Thibaut, Bricout, Nicolas, Moïse, Martin, Testud, Benoit, Vingadassalom, Sivadji, Ifergan, Héloïse, Janot, Kévin, Consoli, Arturo, Ben Hassen, Wagih, Shotar, Eimad, Ognard, Julien, Charbonnier, Guillaume, L’Allinec, Vincent, Guédon, Alexis, Bolognini, Federico, Marnat, Gaultier, Forestier, Géraud, Rouchaud, Aymeric, Pop, Raoul, Raynaud, Nicolas, Zhu, François, Cortese, Jonathan, Chalumeau, Vanessa, Berge, Jérome, Escalard, Simon, Boulouis, Grégoire, Chivot, Cyril, Hanafi, Riyad, Pasco, Anne, Girot, Jean-Baptiste, Biondi, Alessandra, Di Caterino, Fortunato, Primikiris, Panagiotis, Vitale, Giovanni, Bonnet, Louise, Gariel, Florent, Barreau, Xavier, Debruxelles, Sabrina, Lucas, Ludovic, Menegon, Patrice, Olindo, Stéphane, Poli, Mathilde, Renou, Pauline, Sagnier, Sharmila, Sibon, Igor, Veunac, Louis, Gentric, Jean-Christophe, Barbier, Charlotte, Boulanger, Marion, Cogez, Julien, Guettier, Sophie, Schneckenburger, Romain, Touze, Emmanuel, Delaitre, Mariette, Lebendinsky, Pablo, Musacchio, Mariano, Ricolfi, Frédéric, Thouant, Pierre, Caparros, François, Casolla, Barbara, Della Schiava, Lucie, Dequatre, Nelly, Henon, Hilde, Pasi, Marco, Kazemi, Apolline, Bala, Fouzi, Estrade, Laurent, Mounayer, Charbel, Saleme, Susanna, Macian-Montoro, Francisco, Eker, Omer, Cotton, François, Blanc-Lasserre, Karine, Cakmak, Serkan, Cho, Tae-Hee, Derex, Laurent, Lukaszewicz, Anne-Claire, Mechtouff, Laura, Nighoghossian, Norbert, Philippeau, Frédéric, Riva, Roberto, Turjman, Francis, Vallet, Anne-Evelyne, Carle, Xavier, Dory-Lautrec, Philippe, Reyre, Anthony, Hak, Jean-François, Brunel, Hervé, Benali, Amel, Collemiche, François-Louis, Dargazanli, Cyril, Cagnazzo, Frederico, Derraz, Imad, Arquizan, Caroline, Corti, Lucas, Costalat, Vincent, Gaillard, Nicolas, Gascou, Grégory, Lefèvre, Pierre-Henri, Mourand, Isabelle, Riquelme, Carlos, Derelle, Anne Laure, Gory, Benjamin, Liao, Liang, Tonnelet, Romain, Anxionnat, René, Bonnerot, Mathieu, Bracard, Serge, Braun, Marc, Humbertjean, Lisa, Lacour, Jean-Christophe, Mione, Gioia, Planel, Sophie, Richard, Sébastien, Riou-Comte, Nolwenn, Schmitt, Emmanuelle, Bourcier, Romain, Detraz, Lili, Desal, Hubert, Alexandre, Pierre-Louis, Daumas-Duport, Benjamin, Lenoble, Cédric, Roy, Monica, Coskun, Oghuzan, Di Maria, Frederico, Lapergue, Bertrand, Rodesch, Georges, Wang, Adrien, Weisenburger-Lile, David, Zimatore, Sergio, Ajili, Nadia, Buard, Géraldine, Evrard, Serge, Gorza, Lucas, Gratieux, Julie, Leguen, Morgan, Marinier, Sylvie, Pico, Fernando, Poll, Roxanna, Rakotoharinandrasana, Haja, Tassan, Philippe, Tchikviladze, Maya, Delvoye, François, Hebert, Solène, Blanc, Raphaël, Ciccio, Gabriele, Desilles, Jean-Philippe, Maier, Benjamin, Mazighi, Mikael, Piotin, Michel, Redjem, Hocine, Smajda, Stanislas, Ben Maacha, Malek, Corabianu, Ovide, De Broucker, Thomas, Ille, Olivier, Manchon, Eric, Obadia, Michael, Obadia, Mickael, Raynouard, Igor, Peres, Roxanne, Sabben, Candice, Smadja, Didier, Taylor, Guillaume, Thion, Laurie-Anne, Lecler, Augustin, Denier, Christian, Caroff, Jildaz, Chassin, Olivier, Spelle, Laurent, Venditti, Laura, Aymard, Armand, Betty, Jean, Civelli, Vittorio, Eliezer, Michael, Fantoni, Matteo, Houdart, Emmanuel, Labeyrie, Marc-Antoine, Saint Maurice, Jean-Pierre, Kalsoum, Erwah, Pacini, Aurelien, Ramadane, Chawkat, Tuilier, Titien, Villain, Adrien, Clarencon, Frédéric, Degos, Vincent, Elhfnawy, Ahmed, Elhorany, Mahmoud, Lenck, Stéphanie, Premat, Kevin, Sourour, Nader-Antoine, Alamowitch, Sonia, Baronnet, Flore, Crozier, Sophie, Deltour, Sandrine, Leger, Anne, Rosso, Charlotte, Pyatigorskaya, Nadya, Rodriguez Regent, Christine, Trystram, Denis, Naggara, Olivier, Seners, Pierre, Turc, Guillaume, Edjlali, Myriam, Agbonon, Rémi, Alotaibi, Mohammed, Sonchet, Antoine, Oppenheim, Catherine, Meder, Jean François, Benzakoun, Joseph, Legrand, Laurence, Fauché, Cédric, Velasco, Stéphane, Manceau, Pierre François, Moulin, Sebastien Solène Soize, Ferré, Jean-Christophe, Paya, Christophe, Eugene, François, Gauvrit, Jean-Yves, Langnier-Lemercier, Sophie, Lassale, Maria, Raoult, helene, Ronziere, Thomas, Tracol, Clément, Vannier, Stéphane, Burel, Julien, Le Moal, Julien, Papagiannaki, Chrysanthi, Aggour, Mohamed, Sachet, Marina, Boutet, Claire, Beaujeux, Remy, Hasiu, Anca, Manisor, Monica, Mihoc, Dan, Kremer, Stéphane, Arteaga, Charles, Gazzola, Sébastien, Darcourt, Jean, Cognard, Christophe, Bonneville, Fabrice, Christine Januel, Anne, Olivot, Jean-Marc, Raposo, Nicolas, Viguier, Alain, Bibi, Richard, Boustia, Fakhreddine, Herbreteau, Denis, Maldonado, Igor, Narata, Ana-Paula, Service de neuroradiologie [Paris], Hôpital Sainte-Anne, CHU Strasbourg, Service de neuroradiologie [Lille], Hôpital Roger Salengro [Lille]-Université de Lille, Droit et Santé-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Service de neuroradiologie diagnostique et interventionnelle, Université de la Méditerranée - Aix-Marseille 2-Assistance Publique - Hôpitaux de Marseille (APHM)- Hôpital de la Timone [CHU - APHM] (TIMONE), Service de neuroradiologie [Tours], Centre Hospitalier Régional Universitaire de Tours (CHRU Tours), Service Neuroradiologie diagnostique et interventionnelle [Hôpital Foch], Hôpital Foch [Suresnes], Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Service de Neuroradiologie [CHU Pitié-Salpêtrière], CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neuroradiologie [Brest], Centre Hospitalier Régional Universitaire de Brest (CHRU Brest), Centre Hospitalier Régional Universitaire de Besançon (CHRU Besançon), Centre Hospitalier Universitaire d'Angers (CHU Angers), PRES Université Nantes Angers Le Mans (UNAM), Hôpital Lariboisière-Fernand-Widal [APHP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Service de Neurologie [Hôpitaux Civils de Colmar], Hôpitaux Civils Colmar, Département de Neuro-Radiologie [Bordeaux] (DNR - Bordeaux), CHU Bordeaux [Bordeaux], Service de Neuroradiologie interventionnelle [CHU Limoges], CHU Limoges, Département de Neuroradiologie [Strasbourg], Les Hôpitaux Universitaires de Strasbourg (HUS), Service de neurologie [Poitiers], Centre hospitalier universitaire de Poitiers (CHU Poitiers), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Service de Neuroradiologie [CHU de Bicêtre], Hôpital Rothschild [AP-HP], Faculté de Médecine [Nancy], Université de Lorraine (UL), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Rothschild [AP-HP], Centre Hospitalier Régional Universitaire de Tours (CHRU TOURS), Service de neuroradiologie diagnostique et fonctionnelle [CHU Pitié-Salpêtrière], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], and Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU)

Subjects
[SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Background and Purpose: The efficiency of prehospital care chain response and the adequacy of hospital resources are challenged amid the coronavirus disease 2019 (COVID-19) outbreak, with suspected consequences for patients with ischemic stroke eligible for mechanical thrombectomy (MT). Methods: We conducted a prospective national-level data collection of patients treated with MT, ranging 45 days across epidemic containment measures instatement, and of patients treated during the same calendar period in 2019. The primary end point was the variation of patients receiving MT during the epidemic period. Secondary end points included care delays between onset, imaging, and groin puncture. To analyze the primary end point, we used a Poisson regression model. We then analyzed the correlation between the number of MTs and the number of COVID-19 cases hospitalizations, using the Pearson correlation coefficient (compared with the null value). Results: A total of 1513 patients were included at 32 centers, in all French administrative regions. There was a 21% significant decrease (0.79; [95%CI, 0.76–0.82]; P

Published
2020

126. MT in anticoagulated patients

Author

L'allinec, Vincent, Sibon, Igor, Mazighi, Mikael, Labreuche, Julien, Kyheng, MaÉva, Boissier, Elodie, Roy, Monica, Gory, Benjamin, Dargazanli, Cyril, Desal, Hubert, Lapergue, Bertrand, Bourcier, Romain, unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Hôpital Haut-Lévêque [CHU Bordeaux], CHU Bordeaux [Bordeaux], Fondation Ophtalmologique Adolphe de Rothschild [Paris], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Evaluation des technologies de santé et des pratiques médicales - ULR 2694 (METRICS), Université de Lille-Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Imagerie Adaptative Diagnostique et Interventionnelle (IADI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Lorraine (UL), Département de neuroradiologie diagnostique et thérapeutique [CHRU Nancy], Centre Hospitalier Régional Universitaire de Nancy (CHRU Nancy), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), and Université de Nantes (UN)-Université de Nantes (UN)

Subjects
[INFO.INFO-IM]Computer Science [cs]/Medical Imaging, [SDV.IB.MN]Life Sciences [q-bio]/Bioengineering/Nuclear medicine, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

International audience; Mechanical thrombectomy (MT) is one of the main treatments for acute ischemic stroke (AIS) in patients on effective anticoagulation. The use of direct oral anticoagulants (DOA) has increased, given their efficacy and safety profile compared to vitamin K antagonists (VKA). We compared procedural and clinical outcomes of MT in patients on DOA and VKA treatment before stroke onset. We analyzed 2 groups from the Endovascular Treatment in Ischemic Stroke prospective registry: patients on DOA and patients on VKA treated by MT without thrombolysis. Generalized linear mixed models including center as random effect were used to compare angiographic (rates of reperfusion at end of procedure, number of passes >2, procedural complications) and clinical (favorable and excellent outcome, 90-day all-cause mortality, and hemorrhagic complications) outcomes according to anticoagulation subgroups. Comparisons were adjusted for prespecified confounders (age, admission NIH Stroke Scale score) as well as for meaningful baseline between-group differences. Among 221 patients included, more DOA-treated patients (n = 115, 52%) achieved successful (modified Thrombolysis in Cerebral Infarction score [mTICI] 2b/3) or near complete (mTICI 2c/3) reperfusion at the procedure end than did VKA-treated patients, with an adjusted odds ratio (OR) for DOA vs VKA of 3.27 (95% confidence interval [CI], 1.40–7.65) and 2.00 (95% CI, 1.08–3.73), respectively. DOA-treated patients had a lower 90-day mortality risk with an adjusted OR of 0.47 (95% CI, 0.24–0.89) and a better excellent outcome OR of 2.40 (1.10–5.27). There was no significant between-group difference in hemorrhagic or procedural complications. The study highlights the benefits of DOA compared to VKA. Regarding mortality, excellent outcomes, and recanalization rate, DOA appears to provide a favorable setting for MT treatment in AIS.

Published
2020

127. sj-pdf-1-wso-10.1177_1747493020923051 - Supplemental material for Identifying the predictors of first-pass effect and its influence on clinical outcome in the setting of endovascular thrombectomy for acute ischemic stroke: Results from a multicentric prospective registry

Author

Maria, Federico Di, Maéva Kyheng, Consoli, Arturo, Jean-Philippe Desilles, Gory, Benjamin, Richard, Sébastien, Rodesch, Georges, Labreuche, Julien, Jean-Baptiste Girot, Dargazanli, Cyril, Marnat, Gaultier, Lapergue, Bertrand, and Bourcier, Romain

Subjects
FOS: Clinical medicine, Cardiology, Medicine, 110904 Neurology and Neuromuscular Diseases
Abstract

Supplemental material, sj-pdf-1-wso-10.1177_1747493020923051 for Identifying the predictors of first-pass effect and its influence on clinical outcome in the setting of endovascular thrombectomy for acute ischemic stroke: Results from a multicentric prospective registry by Federico Di Maria, Maéva Kyheng, Arturo Consoli, Jean-Philippe Desilles, Benjamin Gory, Sébastien Richard, Georges Rodesch, Julien Labreuche, Jean-Baptiste Girot, Cyril Dargazanli, Gaultier Marnat, Bertrand Lapergue, Romain Bourcier and on behalf of the ETIS investigators*in International Journal of Stroke

Published
2020
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128. Microbleeds, Cerebral Hemorrhage, and Functional Outcome After Endovascular Thrombectomy

Author

Derraz, Imad, primary, Cagnazzo, Federico, additional, Gaillard, Nicolas, additional, Morganti, Riccardo, additional, Dargazanli, Cyril, additional, Ahmed, Raed, additional, Lefevre, Pierre-Henri, additional, Riquelme, Carlos, additional, Mourand, Isabelle, additional, Gascou, Gregory, additional, Bonafe, Alain, additional, Arquizan, Caroline, additional, and Costalat, Vincent, additional

Published
2021
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129. European Multicenter Study of ET-COVID-19

Author

Cagnazzo, Federico, primary, Piotin, Michel, additional, Escalard, Simon, additional, Maier, Benjamin, additional, Ribo, Marc, additional, Requena, Manuel, additional, Pop, Raoul, additional, Hasiu, Anca, additional, Gasparotti, Roberto, additional, Mardighian, Dikran, additional, Piano, Mariangela, additional, Cervo, Amedeo, additional, Eker, Omer Faruk, additional, Durous, Vincent, additional, Sourour, Nader-Antoine, additional, Elhorany, Mahmoud, additional, Zini, Andrea, additional, Simonetti, Luigi, additional, Marcheselli, Simona, additional, Paolo, Nuzzi Nunzio, additional, Houdart, Emmanuel, additional, Guédon, Alexis, additional, Ligot, Noémie, additional, Mine, Benjamin, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, Cordona Portela, Pere, additional, Urra, Xabier, additional, Rodriguez, Alejandro, additional, Bolognini, Federico, additional, Lebedinsky, Pablo Ariel, additional, Pasco-Papon, Anne, additional, Godard, Sophie, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Limbucci, Nicola, additional, Nencini, Patrizia, additional, Nappini, Sergio, additional, Saia, Valentina, additional, Caldiera, Valentina, additional, Romano, Daniele, additional, Frauenfelder, Giulia, additional, Gallesio, Ivan, additional, Gola, Giuliano, additional, Menozzi, Roberto, additional, Genovese, Antonio, additional, Terrana, Alberto, additional, Giorgianni, Andrea, additional, Cappellari, Manuel, additional, Augelli, Raffaele, additional, Invernizzi, Paolo, additional, Pavia, Marco, additional, Lafe, Elvis, additional, Cavallini, Anna, additional, Giossi, Alessia, additional, Besana, Michele, additional, Valvassori, Luca, additional, Macera, Antonio, additional, Castellan, Lucio, additional, Salsano, Giancarlo, additional, Di Caterino, Fortunato, additional, Biondi, Alessandra, additional, Arquizan, Caroline, additional, Lebreuche, Julien, additional, Galvano, Gianluca, additional, Cannella, Alfio, additional, Cosottini, Mirco, additional, Lazzarotti, Guido, additional, Guizzardi, Giuseppe, additional, Stecco, Alessandro, additional, Tassi, Rossana, additional, Bracco, Sandra, additional, Bianchini, Elena, additional, Micieli, Camilla, additional, Pascarella, Rosario, additional, Napoli, Manuela, additional, Causin, Francesco, additional, Desal, Hubert, additional, Cotton, François, additional, Costalat, Vincent, additional, Delvoye, François, additional, Ciccio, Gabriele, additional, Smajda, Stanislas, additional, Redjem, Hocine, additional, Hébert, Solène, additional, Blanc, Raphaël, additional, Mazighi, Mikael, additional, Desilles, Jean-Philippes, additional, Mihoc, Dan, additional, Manisor, Monica, additional, Beaujeux, Rémy, additional, Quenardelle, Véronique, additional, Gheoca, Roxana, additional, Wolff, Valérie, additional, Pero, Guiglielmo, additional, Giuditta, Giussani, additional, Chiara, Ceresa, additional, Riva, Roberto, additional, Cappucci, Matteo, additional, Laubacher, Morgane, additional, Tuttle, Celia, additional, Piergallini, Lorenzo, additional, Turjman, Francis, additional, Clarençon, Frédéric, additional, Shotar, Eimad, additional, Lenck, Stéphanie, additional, Premat, Kevin, additional, Degos, Vincent, additional, Samson, Yves, additional, Rosso, Charlotte, additional, Alamowitch, Sonia, additional, Cirillo, Luigi, additional, Gentile, Mauro, additional, Migliaccio, Ludovica, additional, Isceri, Salvatore, additional, Rossi, Simone, additional, Baldini, Tommaso, additional, Dall’Olio, Massimo, additional, Cellerini, Martino, additional, Saint-Maurice, Jean-Pierre, additional, Civelli, Vittorio, additional, Fantoni, Matteo, additional, Gilles, Naeije, additional, Lise, Jodaïtis, additional, Boris, Lubicz, additional, Elens, Stephanie, additional, Thomas, Bonnet, additional, Adrien, Guenego, additional, Niloufar, Sadeghi, additional, Marc, Van Nuffelen, additional, Maria, Federico Di, additional, Coskun, Oguzhan, additional, Rodesch, Georges, additional, Zimatore, Sergio, additional, Florent, Gariel, additional, Berge, Jérôme, additional, Menegon, Patrice, additional, Barreau, Xavier, additional, Tourdias, Thomas, additional, Olindo, Stéphane, additional, Lucas, Ludovic, additional, Liegey, Jean-Sebastien, additional, Sagnier, Sharmila, additional, Renou, Pauline, additional, Couture, Marie, additional, Debruxelles, Sabrina, additional, Poli, Mathilde, additional, Musacchio, Mariano, additional, Delaitre, Mariette, additional, Padolecchia, Riccardo, additional, Ganci, Giuseppe, additional, Sugo, Annalisa, additional, Stefano, Barbero, additional, Giovanni, Taverna Giacomo, additional, Scoditti, Umberto, additional, Castellini, Paola, additional, Latte, Lilia, additional, Grisendi, Ilaria, additional, Epifani, Enrico, additional, Vizzari, Francesco, additional, Molinaro, Stefano, additional, Nativo, Luca, additional, Vinacci, Gabriele, additional, Bonetti, Bruno, additional, Micheletti, Nicola, additional, Tomelleri, Giampaolo, additional, Zampieri, Piergiuseppe, additional, Plebani, Mauro, additional, Grazioli, Andrea, additional, Ricciardi, Giuseppe Kenneth, additional, Polistena, Alessandra, additional, Alessando, Sgreccia, additional, Sanfilippo, Giuseppina, additional, Persico, Alessandra, additional, Boadu, William, additional, Cuzzoni, Maria Giovanna, additional, Magno, Serena, additional, Toscano, Gianpaolo, additional, Denaro, Maria Federica, additional, Tosi, Piera, additional, Censori, Bruno, additional, Puglisi, Valentina, additional, Vinciguerra, Luisa, additional, De Giuli, Valeria, additional, Mavillo, Nicola, additional, Renieri, Leonardo, additional, Fainardi, Enrico, additional, Vitale, Giovanni, additional, Panagiotis, Primikiris, additional, Charbonnier, Guillaume, additional, Claudio, Moratti, additional, Sallustio, Fabrizio, additional, Wlderk, Andrea, additional, Russo, Riccardo, additional, Bergui, Mauro, additional, Comelli, Chiara, additional, Boghi, Andrea, additional, Moynier, Marinette, additional, Maria Ciceri, Elisa Francesca, additional, Toni, Danilo, additional, Frandon, Julien, additional, Mourand, Isabelle, additional, Gaillard, Nicolas, additional, Mangiafico, Salvatore, additional, Derraz, Imad, additional, Dargazanli, Cyril, additional, Lefevre, Pierre-Henri, additional, Riquelme, Carlos, additional, Gascou, Gregory, additional, and Bonafe, Alain, additional

Published
2021
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130. Comparison of Woven EndoBridge device sizing with conventional measurements and virtual simulation using the Sim&Size software: a multicenter experience

Author

Cagnazzo, Federico, primary, Marnat, Gaultier, additional, Ferreira, Ivan, additional, Daube, Pierre, additional, Derraz, Imad, additional, Dargazanli, Cyril, additional, Lefevre, Pierre-Henri, additional, Gascou, Gregory, additional, Riquelme, Carlos, additional, Morganti, Riccardo, additional, Berge, Jérôme, additional, Gariel, Florent, additional, Barreau, Xavier, additional, and Costalat, Vincent, additional

Published
2020
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131. First-line thrombectomy strategy for anterior large vessel occlusions: results of the prospective ETIS egistry.

Author

Maïer, Benjamin, Finitsis, Stephanos, Bourcier, Romain, Papanagiotou, Panagiotis, Richard, Sébastien, Marnat, Gaultier, Sibon, Igor, Dargazanli, Cyril, Arquizan, Caroline, Blanc, Raphael, Piotin, Michel, Lapergue, Bertrand, Consoli, Arturo, Eugene, Francois, Vannier, Stephane, Saleme, Suzana, Macian, Francisco, Clarençon, Frédéric, Rosso, Charlotte, and Naggara, Olivier

Subjects
SAFETY, CONFIDENCE intervals, TREATMENT effectiveness, COMPARATIVE studies, THROMBECTOMY, VASCULAR diseases, ENDOVASCULAR surgery, ODDS ratio, LONGITUDINAL method
Abstract

Background The best recanalization strategy for mechanical thrombectomy (MT) remains unknown as no randomized controlled trial has simultaneously evaluated first-line stent retriever (SR) versus contact aspiration (CA) versus the combined approach (SR+CA). Objective To compare the efficacy and safety profiles of SR, CA, and SR+CA in patients with acute ischemic stroke (AIS) treated by MT. Methods We analyzed data of the Endovascular Treatment in Ischemic Stroke (ETIS) Registry, a prospective, multicenter, observational study of patients with AIS treated by MT. Patients with M1 and intracranial internal carotid artery (ICA) occlusions between January 2015 and March 2020 in 15 comprehensive stroke centers were included. We assessed the association of first-line strategy with favorable outcomes at 3 months (modified Rankin Scale score 0-2), successful recanalization rates (modified Thrombolysis In Cerebral Infarction (mTICI) 2b/3), and safety outcomes. Results We included 2643 patients, 406 treated with SR, 1126 with CA, and 1111 with SR+CA. CA or SR+CA achieved more successful recanalization than SR for M1 occlusions (aOR=2.09, (95% CI 1.39 to 3.13) and aOR=1.69 (95% CI 1.12 to 2.53), respectively). For intracranial ICA, SR+CA achieved more recanalization than SR (aOR=2.52 (95% CI 1.32 to 4.81)), no differences were observed between CA and SR+CA. SR+CA was associated with lower odds of favorable outcomes compared with SR (aOR=0.63 (95% CI 0.44 to 0.90)) and CA (aOR=0.71 (95% CI 0.55 to 0.92)), higher odds of mortality at 3 months (aOR=1.56 (95% CI 1.22 to 2.0)) compared with CA, and higher odds of symptomatic intracranial hemorrhage (aOR=1.59 (95% CI 1.1 to 2.3)) compared with CA. Conclusions Despite high recanalization rates, our results question the safety of the combined approach, which was associated with disability and mortality. Randomized controlled trials are needed to evaluate the efficacy and safety of these techniques. [ABSTRACT FROM AUTHOR]

Published
2022
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132. Endovascular reperfusion of M2 occlusions in acute ischemic stroke reduced disability and mortality: ETIS Registry results.

Author

Muszynski, Patricio, Anadani, Mohammad, Richard, Sébastien, Marnat, Gaultier, Bourcier, Romain, Sibon, Igor, Dargazanli, Cyril, Arquizan, Caroline, Maïer, Benjamin, Blanc, Raphaël, Lapergue, Bertrand, Consoli, Arturo, Eugene, Francois, Vannier, Stephane, Spelle, Laurent, Denier, Christian, Boulanger, Marion, Gauberti, Maxime, Saleme, Suzana, and Macian, Francisco

Subjects
MORTALITY prevention, RESEARCH, ISCHEMIC stroke, SOCIAL services case management, FUNCTIONAL status, NIH Stroke Scale, THROMBOLYTIC therapy, TREATMENT effectiveness, CEREBRAL arteries, ENDOVASCULAR surgery, REPERFUSION, VOCATIONAL rehabilitation, LONGITUDINAL method
Abstract

Background The predictors of successful reperfusion and the effect of reperfusion after endovascular treatment (EVT) for M2 occlusions have not been well studied. We aimed to identify predictors of successful reperfusion and the effect of reperfusion on outcomes of EVT for M2 occlusions in current practice. Methods Patients with acute ischemic stroke due to isolated M2 occlusions who were enrolled in the prospective multicenter Endovascular Treatment in Ischemic Stroke (ETIS) Registry in France between January 2015 and March 2020 were included. The primary outcome was a favorable outcome, defined as modified Rankin Scale (mRS) score of 0-2 at 90 days. Successful reperfusion was defined as an improvement of ≥1 points in the modified Thrombolysis In Cerebral Infarction score between the first and the last intracranial angiogram. Results A total of 458 patients were included (median National Institutes of Health Stroke Scale (NIHSS) score 14; 61.4% received prior intravenous thrombolysis). Compared with the non-reperfused patients, reperfused patients had an increased rate of excellent outcome (OR 2.3, 95% CI 0.98 to 5.36; p=0.053), favorable outcome (OR 2.79, 95% CI 1.31 to 5.93; p=0.007), and reduced 90-day mortality (OR 0.39, 95% CI 0.19 to 0.79; p<0.01). Admission NIHSS score was the only predictor of successful reperfusion. First-line strategy was not a predictor of successful reperfusion or favorable outcome, but the use of a stent retriever, alone or with an aspiration catheter, was associated with higher rates of procedural complications and 90-day mortality. Conclusions Successful reperfusion of M2 occlusions reduced disability and mortality. However, safety is a concern, especially if the procedure failed. [ABSTRACT FROM AUTHOR]

Published
2022
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133. Endovascular therapy with or without intravenous thrombolysis in acute stroke with tandem occlusion.

Author

Anadani, Mohammad, Marnat, Gaultier, Consoli, Arturo, Papanagiotou, Panagiotis, Nogueira, Raul G., Spiotta, Alejandro M., Bourcier, Romain, Kyheng, Maeva, Labreuche, Julien, Siddiqui, Adnan H., Ribo, Marc, de Havenon, Adam, Fischer, Urs, Sibon, Igor, Dargazanli, Cyril, Arquizan, Caroline, Cognard, Christophe, Olivot, Jean Marc, Anxionnat, René, and Audibert, Gérard

Subjects
CEREBRAL embolism & thrombosis, INTRAVENOUS therapy, ISCHEMIC stroke, THROMBOLYTIC therapy, VEIN surgery, THROMBECTOMY, ENDOVASCULAR surgery
Abstract

Background Endovascular therapy (EVT) is effective and safe in patients with tandem occlusion. The benefit of intravenous thrombolysis (IVT) prior to EVT in acute tandem occlusion is debatable. Objective To compare EVT alone with EVT plus IVT in patients with acute ischemic stroke due to anterior circulation tandem occlusions. Methods This is an individual patient pooled analysis of the Thrombectomy In TANdem lesions (TITAN) and Endovascular Treatment in Ischemic Stroke (ETIS) Registries. Patients were divided into two groups based on prior IVT treatment: (1) IVT+ group, which included patients who received IVT prior to EVT, (2) IVT--group, which included patients who did not receive IVT prior to EVT. Propensity score (inverse probability of treatment weighting (IPTW)) was used to reduce baseline between-group differences. The primary outcome was favorable outcome--that is, modified Rankin Scale (mRS) score 0 to 2 at 90 days. Results Overall, 602 consecutive patients with an acute stroke with tandem occlusion were included (380 and 222 in the bridging therapy and EVT alone groups, respectively). Onset to imaging time was shorter in the IVT+ group (median 103 vs 140 min). In contrast, imaging to puncture time was longer in the IVT+ group (median 107 vs 91 min). In IPTW analysis, the IVT+ group had higher odds of favorable outcome, excellent outcome (90-day mRS score 0-1), and successful reperfusion (modified Thrombolysis in Cerebral Infarction score 2b/3 at the end of EVT). There was no difference in the risk of significant hemorrhagic complications between groups. In secondary analysis of patients treated with acute cervical internal carotid artery stenting, bridging therapy was associated with higher odds of favorable outcome and lower odds of mortality at 90 days. Conclusions Our results suggest that bridging therapy in patients with acute ischemic stroke due to anterior tandem occlusion is safe and may improve functional outcome, even in the setting of acute cervical internal carotid artery stenting during EVT. [ABSTRACT FROM AUTHOR]

Published
2022
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134. DWI cerebellar infarct volume as predictor of outcomes after endovascular treatment of acute basilar artery occlusion

Author

Mourand, Isabelle, primary, Mahmoudi, Mehdi, additional, Dargazanli, Cyril, additional, Pavillard, Frederique, additional, Arquizan, Caroline, additional, Labreuche, Julien, additional, Derraz, Imad, additional, Gaillard, Nicolas, additional, Blanchet-Fourcade, Genevieve, additional, Lefevre, Pierre Henri, additional, Boukriche, Yassine, additional, Gascou, Gregory, additional, Corti, Lucas, additional, Costalat, Vincent, additional, Le bars, Emmanuelle, additional, and Cagnazzo, Federico, additional

Published
2020
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135. Impact of endovascular reperfusion therapy in nonagenarians with anterior circulation large-vessel ischaemic stroke

Author

Derraz, Imad, primary, Benali, Amel, additional, Ahmed, Raed, additional, Cagnazzo, Federico, additional, Dargazanli, Cyril, additional, Gascou, Gregory, additional, Riquelme, Carlos, additional, Corti, Lucas, additional, Lefevre, Pierre-Henri, additional, Bonafe, Alain, additional, Arquizan, Caroline, additional, and Costalat, Vincent, additional

Published
2020
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136. Machine Learning Analysis of the Cerebrovascular Thrombi Proteome in Human Ischemic Stroke: An Exploratory Study

Author

Dargazanli, Cyril, primary, Zub, Emma, additional, Deverdun, Jeremy, additional, Decourcelle, Mathilde, additional, de Bock, Frédéric, additional, Labreuche, Julien, additional, Lefèvre, Pierre-Henri, additional, Gascou, Grégory, additional, Derraz, Imad, additional, Riquelme Bareiro, Carlos, additional, Cagnazzo, Federico, additional, Bonafé, Alain, additional, Marin, Philippe, additional, Costalat, Vincent, additional, and Marchi, Nicola, additional

Published
2020
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138. Rescue carotid puncture for ischemic stroke treated by endovascular therapy: a multicentric analysis and systematic review

Author

Allard, Julien, primary, Ghazanfari, Sam, additional, Mahmoudi, Mehdi, additional, Labreuche, Julien, additional, Escalard, Simon, additional, Delvoye, François, additional, Ciccio, Gabriele, additional, Smajda, Stanislas, additional, Redjem, Hocine, additional, Hebert, Solène, additional, Consoli, Arturo, additional, Costalat, Vincent, additional, Desilles, Jean-Philippe, additional, Mazighi, Mikael, additional, Piotin, Michel, additional, Dargazanli, Cyril, additional, Lapergue, Bertrand, additional, Blanc, Raphaël, additional, and Maïer, Benjamin, additional

Published
2020
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140. “Adaptative endovascular strategy to the CloT MRI in large intracranial vessel occlusion” (VECTOR): Study protocol of a randomized control trial

Author

Janot, Kevin, primary, Zhu, François, additional, Kerleroux, Basile, additional, Boulouis, Grégoire, additional, Shotar, Eimad, additional, Premat, Kevin, additional, Eugene, François, additional, Dargazanli, Cyril, additional, Chalumeau, Vanessa, additional, L’Allinec, Vincent, additional, Benhassen, Wagih, additional, Marnat, Gaultier, additional, Lebras, Anthony, additional, Detraz, Lili, additional, Ognard, Julien, additional, Personnic, Thomas, additional, Chivot, Cyril, additional, Cappucci, Matteo, additional, Forestier, Géraud, additional, Soize, Sébastien, additional, Bourdain, Frédéric, additional, Consoli, Arthuro, additional, Labreuche, Julien, additional, Desal, Hubert, additional, Lapergue, Bertrand, additional, Rouchaud, Aymeric, additional, and Bourcier, Romain, additional

Published
2020
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141. Symptomatic isolated internal carotid artery occlusion with initial medical management: a monocentric cohort

Author

Ter Schiphorst, Adrien, primary, Gaillard, Nicolas, additional, Dargazanli, Cyril, additional, Mourand, Isabelle, additional, Corti, Lucas, additional, Charif, Mahmoud, additional, Ayrignac, Xavier, additional, Lippi, Anaïs, additional, Bouly, Stéphane, additional, Thibault, Lalu, additional, Sablot, Denis, additional, Blanchet-Fourcade, Genevieve, additional, Landragin, Nicolas, additional, Costalat, Vincent, additional, Duflos, Claire, additional, and Arquizan, Caroline, additional

Published
2020
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143. Balloon Guide Catheter is Not Superior to Conventional Guide Catheter when Stent Retriever and Contact Aspiration are Combined for Stroke Treatment

Author

Bourcier, Romain, primary, Marnat, Gaultier, additional, Labreuche, Julien, additional, Desal, Hubert, additional, Maria, Federico Di, additional, Consoli, Arturo, additional, Eugène, François, additional, Gory, Benjamin, additional, Dargazanli, Cyril, additional, Blanc, Raphaël, additional, and Lapergue, Bertrand, additional

Published
2020
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144. Embolus Retriever with Interlinked Cages (ERIC) versus conventional stent retrievers for thrombectomy: a propensity score-based analysis

Author

Ducroux, Célina, primary, Renaud, Nicolas, additional, Bourcier, Romain, additional, Marnat, Gaultier, additional, Sibon, Igor, additional, Gory, Benjamin, additional, Richard, Sébastien, additional, Dargazanli, Cyril, additional, Arquizan, Caroline, additional, Eugene, Francois, additional, Vannier, Stephane, additional, Labreuche, Julien, additional, Walker, Gregory, additional, Blanc, Raphaël, additional, Obadia, Mickael, additional, Consoli, Arturo, additional, Lapergue, Bertrand, additional, and Fahed, Robert, additional

Published
2020
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147. Optimal intracranial pressure in patients with aneurysmal subarachnoid hemorrhage treated with coiling and requiring external ventricular drainage

Author

Cagnazzo, Federico, primary, Chalard, Kevin, additional, Lefevre, Pierre-Henri, additional, Garnier, Ocean, additional, Derraz, Imad, additional, Dargazanli, Cyril, additional, Gascou, Gregory, additional, Riquelme, Carlos, additional, Bonafe, Alain, additional, Perrini, Paolo, additional, Di Carlo, Davide Tiziano, additional, Morganti, Riccardo, additional, Le Corre, Marine, additional, Pavillard, Frederique, additional, Perrigault, Pierre-Francois, additional, and Costalat, Vincent, additional

Published
2020
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150. Évaluation par IRM cérébrale après stenting de carotides symptomatiques par technique de protection proximale par ballonnet avec inversion de flux

Author

Hak, Jean-François, primary, Dargazanli, Cyril, additional, Cagnazzo, Federico, additional, Mahmoudi, Mehdi, additional, Collemiche, François-Louis, additional, Gascou, Grégory, additional, Lefèvre, Pierre-Henri, additional, Eker, Omer, additional, Derraz, Imad, additional, Mourand, Isabelle, additional, Gaillard, Nicolas, additional, Charif, Mahmoud, additional, Arquizan, Caroline, additional, and Costalat, Vincent, additional

Published
2020
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