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104. Linking in vitro and ex vivo CB1 activity with serum concentrations and clinical features in 5F-MDMB-PICA users to better understand SCRAs and their metabolites.

Author

Janssens, Liesl K., Hudson, Simon, Wood, David M., Wolfe, Caitlin, Dargan, Paul I., and Stove, Christophe P.

Subjects
CANNABINOID receptors, METABOLITES, SYNTHETIC receptors, GLASGOW Coma Scale, DRUG toxicity, POISONS, CORD blood
Abstract

Synthetic cannabinoid receptor agonists (SCRAs) pose a danger to public health. This study focused on individuals experiencing recreational drug toxicity who had used 5F-MDMB-PICA. Patient records were evaluated regarding vital signs, Glasgow Coma Scale (GCS) and clinical features. Liquid chromatography coupled to high-resolution mass spectrometry (LC-HRMS) confirmed and quantified the presence of 5F-MDMB-PICA (and/or metabolites) as the only SCRA present in the serum of 71 patients. Cannabinoid activity was evaluated by a cannabinoid receptor (CB1) bioassay, to assess the relationship between serum concentrations and ex vivo human CB1 activation potential. Furthermore, a link with the clinical presentation was appraised. 5F-MDMB-PICA and five metabolites were pharmacologically profiled in vitro, revealing theoretically possible contributions of two active in vivo metabolites to overall cannabinoid activity. Serum concentrations of 5F-MDMB-PICA were correlated to the ex vivo cannabinoid activity, revealing a sigmoidal relationship. The latter could also be predicted based on pharmacological characterization of 5F-MDMB-PICA and its metabolites and an in-depth investigation of the bioassay outcome. Clinically, the GCS showed a significant trend (decrease) with increasing ex vivo cannabinoid activity. This is the first study to evaluate possible toxic effects of 5F-MDMB-PICA in a unique large patient cohort. It allows a better understanding of 5F-MDMB-PICA and metabolites in humans, suggesting a negligible contribution by 5F-MDMB-PICA metabolites to the overall cannabinoid activity in serum. Additionally, this work shows that in vitro pharmacological characterization allows close prediction of an individual's ex vivo CB1 activity, the latter showing a relationship with the level of consciousness. [ABSTRACT FROM AUTHOR]

Published
2022
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107. MDMA-related presentations to the emergency departments of the European Drug Emergencies Network plus (Euro-DEN Plus) over the four-year period 2014–2017

Author

Noseda, Roberta, Schmid, Yasmin, Scholz, Irene, Liakoni, Evangelia, Liechti, Matthias E., Dargan, Paul I., Wood, David M., Dines, Alison M., Yates, Christopher, Heyerdahl, Fridtjof, Hovda, Knut E., Giraudon, Isabelle, Ceschi, Alessandro, Lukasz Anand, Anseeuw, Kurt, Badaras, Robertas, Bonnici, Jeffrey, Brvar, Miran, Burke, Rachel, Blazena Caganova, Eyer, Florian, Galicia, Miguel, Geith, Stefanie, Gillebeert, Johan, Grenc, Damjan, Gorozia, Ketevan, Jaffal, Karim, Jürgens, Gesche, Konstari, Jutta, Kutubidze, Soso, Gabija Laubner, Liguts, Viesturs, Lyphout, Cathelijne, Mégarbane, Bruno, Òscar Miró, Moughty, Adrian, O'Connor, Niall, Paasma, Raido, Perez, Juan Ortega, Perminas, Marius, Persett, Per Sverre, Põld, Kristiina, Puiguriguer, Jordi, Radenkova-Saeva, Julia, Rulisek, Jan, Sopirala, Radhika, Stašinskis, Roberts, Surkus, Jonas, Toth, Ibolya, Vallersnes, Odd Martin, Vigorita, Federico, Waldman, Wojciech, W. Stephen Waring, and Zacharov, Sergej

Abstract

3,4-Methylenedioxymethamphetamine (MDMA) remains one of the most commonly used recreational drugs in Europe. Monitoring of Emergency Department (ED) presentations with acute toxicity associated with MDMA is important to determine trends in MDMA use and harms. Data were extracted from the European Drug Emergencies Network (Euro-DEN) Plus database for all ED presentations with acute toxicity involving MDMA use, alone or in combination with other substances, between 1 January 2014 and 31 December 2017. Geographical distribution, time trends, patient demographics, clinical features, management and outcome were analysed. Out of 23,947 presentations, 2013 (8.4%) involved MDMA, used alone (88, 4.4%) or with other substances (1925, 95.6%). The proportion of MDMA presentations varied by country, from over 15% in France to less than 5% in Norway. For the 15 sentinel centres where data were available for all four years, MDMA-related presentations peaked in 2016 (10.4% versus 8.1% in 2015, p p = 0.0002). 1436 (71.3%) presentations involved males. Females were significantly younger than males (median 23 years, interquartile range, IQR, 20–27 years, versus median 25 years, IQR 21–30 years, p versus 43.9%, p = 0.02), were more frequently medically discharged directly from the ED (74.7% versus 62.4%, p = 0.03), and less frequently received sedation (43.5% versus 66.5%, p = 0.003). This large multicentre series of MDMA presentations to EDs showed geographical variation and changes in time trends and in patient demographics. Triangulation with data from complementary sources including seizures, prevalence of use and wastewater analysis, will enable a greater understanding of the public health implications of MDMA use in Europe.

Published
2021
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108. Variation of drugs involved in acute drug toxicity presentations based on age and sex:an epidemiological approach based on European emergency departments

Author

Miró, Òscar, Waring, William S., Dargan, Paul I., Wood, David M., Dines, Alison M., Yates, Christopher, Giraudon, Isabelle, Moughty, Adrian, O'Connor, Niall, Heyerdahl, Fridtjof, Hovda, Knut E., Vallersnes, Odd M., Paasma, Raido, Pold, Kristiina, Jürgens, Gesche, Megarbane, Bruno, Anand, Jacek S., Liakoni, Evangelia, Liechti, Matthias, Eyer, Florian, Zacharov, Sergej, Caganova, Blazena, Bonnici, Jeffrey, Radenkova-Saeva, Julia, Galicia, Miguel, Miró, Òscar, Waring, William S., Dargan, Paul I., Wood, David M., Dines, Alison M., Yates, Christopher, Giraudon, Isabelle, Moughty, Adrian, O'Connor, Niall, Heyerdahl, Fridtjof, Hovda, Knut E., Vallersnes, Odd M., Paasma, Raido, Pold, Kristiina, Jürgens, Gesche, Megarbane, Bruno, Anand, Jacek S., Liakoni, Evangelia, Liechti, Matthias, Eyer, Florian, Zacharov, Sergej, Caganova, Blazena, Bonnici, Jeffrey, Radenkova-Saeva, Julia, and Galicia, Miguel

Abstract

Objective: To analyse the relative percentage of acute recreational drug toxicity emergency department (ED) presentations involving the main drug groups according to age and sex and investigate different patterns based on sex and age strata. Methods: We analysed all patients with acute recreational drug toxicity included by the Euro-DEN Plus dataset (22 EDs in 14 European countries) between October 2013 and December 2016 (39 months). Drugs were grouped as: opioids, cocaine, cannabis, amphetamines, gamma-hydroxybutyrate (GHB), hallucinogens, new psychoactive substances (NPS), benzodiazepines and ketamine. Descriptive data by age and sex are presented and compared among age/sex categories and among drug families. Results: Of 17,371 patients were included during the 39-month period, 17,198 (99.0%) had taken at least one of the investigated drugs (median age: 31 years; 23.9% female; ethanol co-ingestion recorded in 41.5%, unknown in 31.2%; multiple drug use in 37.9%). Opioids (in 31.4% of patients) and amphetamines (23.3%) were the most frequently involved and hallucinogens (1.9%) and ketamine (1.7%) the least. Overall, female patients were younger than males, both in the whole cohort (median age 29 vs. 32 years; p < 0.001) and in all drug groups except benzodiazepines (median age 36 vs. 36 years; p = 0.83). The relative proportion of each drug group was different at every age strata and some patterns could be clearly described: cannabis, NPS and hallucinogens were the most common in patients <20 years; amphetamines, ketamine and cocaine in the 20- to 39-year group; GHB/GBL in the 30- to 39-year group; and opioids and benzodiazepines in patients ≥40 years. Ethanol and other drug co-ingestion was more frequent at middle-ages, and multidrug co-ingestion was more common in females than males. Conclusion: Differences in the drugs involved in acute drug toxicity presentations according to age and sex may be relevant for developing drug-prevention and education progr

Published
2021

116. Effect of the UKʼs revised paracetamol poisoning management guidelines on admissions, adverse reactions and costs of treatment

Author

Bateman, Nicholas D., Carroll, Robert, Pettie, Janice, Yamamoto, Takahiro, Elamin, Muhammad E. M. O., Peart, Lucy, Dow, Margaret, Coyle, Judy, Cranfield, Kristina R., Hook, Christopher, Sandilands, Euan A., Veiraiah, Aravindan, Webb, David, Gray, Alasdair, Dargan, Paul I., Wood, David M., Thomas, Simon H. L., Dear, James W., and Eddleston, Michael

Published
2014
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118. Guidelines for Reporting Case Studies on Extracorporeal Treatments in Poisonings: Methodology

Author

Lavergne, Valéry, Ouellet, Georges, Bouchard, Josée, Galvao, Tais, Kielstein, Jan T., Roberts, Darren M., Kanji, Salmaan, Mowry, James B., Calello, Diane P., Hoffman, Robert S., Gosselin, Sophie, Nolin, Thomas D., Goldfarb, David S., Burdmann, Emmanuel A., Dargan, Paul I., Decker, Brian Scott, Hoegberg, Lotte C., Maclaren, Robert, Megarbane, Bruno, Sowinski, Kevin M., Yates, Christopher, Mactier, Robert, Wiegand, Timothy, and Ghannoum, Marc

Published
2014
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122. Differences in clinical features associated with cannabis intoxication in presentations to European emergency departments according to patient age and sex.

Author

Schmid, Yasmin, Galicia, Miguel, Vogt, Severin B., Liechti, Matthias E., Burillo-Putze, Guillermo, Dargan, Paul I., Dines, Alison M., Giraudon, Isabelle, Heyerdahl, Fridtjof, Hovda, Knut Erik, Wood, David M., Yates, Christopher, and Miró, Òscar

Subjects
HOSPITAL emergency services, OLDER patients, AGE groups, MEDICAL assistance, CHEST pain, WEEDS
Abstract

To investigate if clinical features associated with acute cannabis intoxication in patients presenting to Emergency Departments for medical assistance differ according to patient age and sex. We analysed presentations in the Euro-DEN Plus dataset from 2014 to 2019 in which cannabis was the only drug involved (except for alcohol), and age, sex and alcohol co-ingestion had been recorded. Age was considered as categorical (five groups; <20, 20–29, 30–39, 40–49 and ≥50 years), and sex as binary variable (male/female). We evaluated 12 key clinical features recorded during emergency department (ED) care. Risks of presenting with each of these clinical features according to patient age and sex were calculated by logistic regression models, and adjusted for sex, age and alcohol co-ingestion. 4,268 of 43,633 Euro-DEN presentations (9.8%) fulfilled the inclusion criteria (median age: 26 years (IQR = 20–34), 70% male, 52% co-ingested alcohol). The frequency of clinical features was: anxiety 28%, vomiting 24%, agitation 23%, palpitations 14%, reduced consciousness 13%, acute psychosis 9%, hallucinations 9%, chest pain 7%, headache 6%, hypotension 4%, hypertension 3% and seizures 2%. Patients younger than 20 years more frequently had vomiting (34.7% of cases), reduced consciousness (21.5%), and headache (10.8%); and less frequently acute psychosis (5.5%). Patients older than 49 years more often had hypotension (6.5%) and less frequently vomiting (20%), anxiety (14%), agitation (14%) and reduced consciousness (10%). Males more frequently presented with hypertension (3.7 vs. 1.5%; OR = 2.311, 95%CI = 1.299–3.816), psychosis (10.4 vs 6.3%; 1.948, 1.432–2.430), chest pain (8.1 vs 4.5%; 1.838, 1.390–2.430) and seizures (2.5 vs 1.4%; 1.805, 1.065–3.060), and less frequently with vomiting (21.8 vs 28.2%; 0.793, 0.677–0.930), anxiety (25.4 vs 32.3%; 0.655, 0.561–0.766) and hypotension (2.9 vs 5.8%; 0.485, 0.350–0.671). The prevalence of some clinical features typically associated with acute cannabis intoxication differed according to age and sex. The causes for these differences should be further investigated in order to better understand the pathophysiology of cannabis-related acute toxicity, and they may be relevant particularly for developing prevention campaigns and for treatment in specific sex and/or age groups. [ABSTRACT FROM AUTHOR]

Published
2022
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123. Increasing emergency department attendances in central London with methamphetamine toxicity and associated harms.

Author

Harnett, James T., Dargan, Paul I., Dines, Alison M., Archer, John R. H., Greene, Shaun L., Hunter, Laura J., and Wood, David M.

Abstract

Background: Methamphetamine is a stimulant drug of abuse with increasing prevalence of use worldwide leading to public health concern. While previous research by our group a decade ago found no evidence of increasing harms associated with methamphetamine use in the UK, there are conflicting data on whether or not this is still the case. This paper aims to identify trends in methamphetamine-related harms and characterise the clinical features of ED presentations involving methamphetamine with gamma-hydroxybutyrate/gamma-butyrolactone (GHB/GBL).Methods: We retrospectively interrogated a database of all toxicology-related presentations to two central London EDs, extracting data on drugs involved for presentations relating to methamphetamine between 2005 and 2018 to enable analysis of trends. Further clinical data were extracted for presentations between 2014 and 2018 to give a 4-year case series.Results: A total of 1244 presentations involving the use of methamphetamine were identified. The number of presentations rose from 4 in 2005 (1.9% of all recreational drug presentations) to 294 (16.2%) in 2018. A total of 850 cases were identified for the 2014-2018 case series, 94.9% were male with a median (range) age of 35.1 (16-67) years. The most common clinical features in the methamphetamine presentations were neuropsychiatric: agitation (41.5%), anxiety (35.2%), hallucinations (16.5%) and psychosis (14.8%). GHB/GBL was co-used in 54.2% of presentations and appeared to attenuate the neuropsychiatric features seen. Use of GHB/GBL was associated with a higher Poisoning Severity Score and requirement for level 2/3 (high dependency unit/intensive care unit (ICU)) care.Conclusion: ED attendances in central London relating to methamphetamine use have risen over the last decade. Combining methamphetamine with GHB/GBL is common and is associated with a higher Poisoning Severity Score and need for ICU level care. Further work is required to establish whether further resources need to be directed at this clinical and public health problem. [ABSTRACT FROM AUTHOR]

Published
2022
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124. Non-medical Use of Prescription Gabapentinoids (Gabapentin and Pregabalin) in Five European Countries

Author

Fonseca, Francina, primary, Lenahan, William, additional, Dart, Richard C., additional, Papaseit, Esther, additional, Dargan, Paul I., additional, Wood, David M., additional, Guareschi, Marilena, additional, Maremmani, Icro, additional, Auriacombe, Marc, additional, Farré, Magí, additional, Scherbaum, Norbert, additional, and Torrens, Marta, additional

Published
2021
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130. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Murray, Christopher J.L., Aravkin, Aleksandr Y., Zheng, Peng, Abbafati, Cristiana, Abbas, Kaja M., Abbasi-Kangevari, Mohsen, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abegaz, Kedir Hussein, Abolhassani, Hassan, Aboyans, Victor, Abreu, Lucas Guimarães, Abrigo, Michael R.M., Abualhasan, Ahmed, Abu-Raddad, Laith Jamal, Abushouk, Abdelrahman I., Adabi, Maryam, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O., Adham, Davoud, Advani, Shailesh M., Agarwal, Gina, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Akalu, Temesgen Yihunie, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akombi, Blessing, Akunna, Chisom Joyqueenet, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Samiah, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M., Alemu, Biresaw wassihun, Alhabib, Khalid F., Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M., Alonso, Jordi, Altirkawi, Khalid A., Amini-Rarani, Mostafa, Amiri, Fatemeh, Amugsi, Dickson A., Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A., Andrei, Catalina Liliana, Andrei, Tudorel, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antonazzo, Ippazio Cosimo, Antonio, Carl Abelardo T., Antony, Catherine M., Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Ariani, Filippo, Armoon, Bahram, Ärnlöv, Johan, Arzani, Afsaneh, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A., Ashbaugh, Charlie, Assmus, Michael, Atafar, Zahra, Atnafu, Desta Debalkie, Atout, Maha Moh d.Wahbi, Ausloos, Floriane, Ausloos, Marcel, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Badawi, Alaa, Badiye, Ashish D., Bahrami, Mohammad Amin, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M., Baldasseroni, Alberto, Ball, Kylie, Ballew, Shoshana H., Balzi, Daniela, Banach, Maciej, Banerjee, Srikanta K., Bante, Agegnehu Bante, Baraki, Adhanom Gebreegziabher, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H., Barthelemy, Celine M., Barua, Lingkan, Basu, Sanjay, Baune, Bernhard T., Bayati, Mohsen, Becker, Jacob S., Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bell, Michellr L., Bennitt, Fiona B., Bensenor, Isabela M., Berhe, Kidanemaryam, Berman, Adam E., Bhagavathula, Akshaya Srikanth, Bhageerathy, Reshmi, Bhala, Neeraj, Bhandari, Dinesh, Bhattacharyya, Krittika, Bhutta, Zulfiqar A., Bijani, Ali, Bikbov, Boris, Bin Sayeed, Muhammad Shahdaat, Biondi, Antonio, Birihane, Binyam Minuye, Bisignano, Catherine, Biswas, Raaj Kishore, Bitew, Helen, Bohlouli, Somayeh, Bohluli, Mehdi, Boon-Dooley, Alexandra S., Borges, Guilherme, Borzì, Antonio Maria, Borzouei, Shiva, Bosetti, Cristina, Boufous, Soufiane, Braithwaite, Dejana, Breitborde, Nicholas J.K., Breitner, Susanne, Brenner, Hermann, Briant, Paul Svitil, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle B., Bryazka, Dana, Bumgarner, Blair R., Burkart, Katrin, Burnett, Richard Thomas, Burugina Nagaraja, Sharath, Butt, Zahid A., Caetano dos Santos, Florentino Luciano, Cahill, Leah E., Cámera, Luis LA Alberto, Campos-Nonato, Ismael R., Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J., Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A., Castelpietra, Giulio, Castro, Franz, Causey, Kate, Cederroth, Christopher R., Cercy, Kelly M., Cerin, Ester, Chandan, Joht Singh, Chang, Kai Lan, Charlson, Fiona J., Chattu, Vijay Kumar, Chaturvedi, Sarika, Cherbuin, Nicolas, Chimed-Ochir, Odgerel, Cho, Daniel Youngwhan, Choi, Jee Young Jasmine, Christensen, Hanne, Chu, Dinh Toi, Chung, Michael T., Chung, Sheng Chia, Cicuttini, Flavia M., Ciobanu, Liliana G., Cirillo, Massimo, Classen, Thomas Khaled Dwayne, Cohen, Aaron J., Compton, Kelly, Cooper, Owen R., Costa, Vera Marisa, Cousin, Ewerton, Cowden, Richard G., Cross, Di H., Cruz, Jessica A., Dahlawi, Saad M.A., Damasceno, Albertino Antonio Moura, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Dangel, William James, Danielsson, Anna Karin, Dargan, Paul I., Darwesh, Aso Mohammad, Daryani, Ahmad, Das, Jai K., Das Gupta, Rajat, das Neves, José, Dávila-Cervantes, Claudio Alberto, Davitoiu, Dragos Virgil, De Leo, Diego, Degenhardt, Louisa, DeLang, Marissa, Dellavalle, Robert Paul, Demeke, Feleke Mekonnen, Demoz, Gebre Teklemariam, Demsie, Desalegn Getnet, Denova-Gutiérrez, Edgar, Dervenis, Nikolaos, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, Dias da Silva, Diana, Diaz, Daniel, Dibaji Forooshani, Zahra Sadat, Djalalinia, Shirin, Do, Hoa Thi, Dokova, Klara, Dorostkar, Fariba, Doshmangir, Leila, Driscoll, Tim Robert, Duncan, Bruce B., Duraes, Andre Rodrigues, Eagan, Arielle Wilder, Edvardsson, David, El Nahas, Nevine, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, Elgendy, Islam Y., El-Jaafary, Shaimaa I., Elyazar, Iqbal RF, Emmons-Bell, Sophia, Erskine, Holly E., Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Estep, Kara, Etemadi, Arash, Etisso, Atkilt Esaiyas, Fanzo, Jessica, Farahmand, Mohammad, Fareed, Mohammad, Faridnia, Roghiyeh, Farioli, Andrea, Faro, Andre, Faruque, Mithila, Farzadfar, Farshad, Fattahi, Nazir, Fazlzadeh, Mehdi, Feigin, Valery L., Feldman, Rachel, Fereshtehnejad, Seyed Mohammad, Fernandes, Eduarda, Ferrara, Giannina, Ferrari, Alize J., Ferreira, Manuela L., Filip, Irina, Fischer, Florian, Fisher, James L., Flor, Luisa Sorio, Foigt, Nataliya A., Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Force, Lisa M., Foroutan, Masoud, Franklin, Richard Charles, Freitas, Marisa, Fu, Weijia, Fukumoto, Takeshi, Furtado, João M., Gad, Mohamed M., Gakidou, Emmanuela, Gallus, Silvano, Garcia-Basteiro, Alberto L., Gardner, William M., Geberemariyam, Biniyam Sahiledengle, Gebreslassie, Assefa Ayalew Ayalew Ayalew, Geremew, Abraham, Gershberg Hayoon, Anna, Gething, Peter W., Ghadimi, Maryam, Ghadiri, Keyghobad, Ghaffarifar, Fatemeh, Ghafourifard, Mansour, Ghamari, Farhad, Ghashghaee, Ahmad, Ghiasvand, Hesam, Ghith, Nermin, Gholamian, Asadollah, Ghosh, Rakesh, Gill, Paramjit Singh, Ginindza, Themba G.G., Giussani, Giorgia, Gnedovskaya, Elena V., Goharinezhad, Salime, Gopalani, Sameer Vali, Gorini, Giuseppe, Goudarzi, Houman, Goulart, Alessandra C., Greaves, Felix, Grivna, Michal, Grosso, Giuseppe, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Guimarães, Rafael Alves, Guled, Rashid Abdi, Guo, Gaorui, Guo, Yuming, Gupta, Rajeev, Gupta, Tarun, Haddock, Beatrix, Hafezi-Nejad, Nima, Hafiz, Abdul, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J., Halvaei, Iman, Hamadeh, Randah R., Hamidi, Samer, Hammer, Melanie S., Hankey, Graeme J., Haririan, Hamidreza, Haro, Josep Maria, Hasaballah, Ahmed I., Hasan, Md Mehedi, Hasanpoor, Edris, Hashi, Abdiwahab, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J., Hay, Simon I., Hayat, Khezar, Heidari, Golnaz, Heidari-Soureshjani, Reza, Henrikson, Hannah J., Herbert, Molly E., Herteliu, Claudiu, Heydarpour, Fatemeh, Hird, Thomas R., Hoek, Hans W., Holla, Ramesh, Hoogar, Praveen, Hosgood, H. Dean, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsairi, Mohamed, Hsieh, Vivian Chia rong, Hu, Guoqing, Hu, Kejia, Huda, Tanvir M., Humayun, Ayesha, Huynh, Chantal K., Hwang, Bing Fang, Iannucci, Vincent C., Ibitoye, Segun Emmanuel, Ikeda, Nayu, Ikuta, Kevin S., Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Inbaraj, Leeberk Raja, Ippolito, Helen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, M. Mofizul, Islam, Sheikh Mohammed Shariful, Iso, Hiroyasu, Ivers, Rebecca Q., Iwu, Chidozie C.D., Iwu, Chinwe Juliana, Iyamu, Ihoghosa Osamuyi, Jaafari, Jalil, Jacobsen, Kathryn H., Jafari, Hussain, Jafarinia, Morteza, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Jalilian, Farzad, James, Spencer L., Janjani, Hosna, Javaheri, Tahereh, Javidnia, Javad, Jeemon, Panniyammakal, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S., Johansson, Lars, John, Oommen, John-Akinola, Yetunde O., Johnson, Catherine Owens, Jonas, Jost B., Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kalani, Hamed, Kalani, Rizwan, Kalankesh, Leila R., Kalhor, Rohollah, Kanchan, Tanuj, Kapoor, Neeti, Karami Matin, Behzad, Karch, André, Karim, Mohd Anisul, Kassa, Getachew Mullu, Katikireddi, Srinivasa Vittal, Kayode, Gbenga A., Kazemi Karyani, Ali, Keiyoro, Peter Njenga, Keller, Cathleen, Kemmer, Laura, Kendrick, Parkes J., Khalid, Nauman, Khammarnia, Mohammad, Khan, Ejaz Ahmad, Khan, Maseer, Khatab, Khaled, Khater, Mona M., Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khazaei, Salman, Kieling, Christian, Kim, Yun Jin, Kimokoti, Ruth W., Kisa, Adnan, Kisa, Sezer, Kivimäki, Mika, Knibbs, Luke D., Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M., Kochhar, Sonali, Kopec, Jacek A., Korshunov, Vladimir Andreevich, Koul, Parvaiz A., Koyanagi, Ai, Kraemer, Moritz U.G., Krishan, Kewal, Krohn, Kris J., Kromhout, Hans, Kuate Defo, Barthelemy, Kumar, G. Anil, Kumar, Vivek, Kurmi, Om P., Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lami, Faris Hasan, Landires, Iván, Lang, Justin J., Langan, Sinéad M., Larsson, Anders O., Lasrado, Savita, Lauriola, Paolo, Lazarus, Jeffrey V., Lee, Paul H., Lee, Shaun Wen Huey, LeGrand, Kate E., Leigh, James, Leonardi, Matilde, Lescinsky, Haley, Leung, Janni, Levi, Miriam, Li, Shanshan, Lim, Lee Ling, Linn, Shai, Liu, Shiwei, Liu, Simin, Liu, Yang, Lo, Justin, Lopez, Alan D., Lopez, Jaifred Christian F., Lopukhov, Platon D., Lorkowski, Stefan, Lotufo, Paulo A., Lu, Alton, Lugo, Alessandra, Maddison, Emilie R., Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Mahmoudi, Morteza, Majeed, Azeem, Maleki, Afshin, Maleki, Shokofeh, Malekzadeh, Reza, Malta, Deborah Carvalho, Mamun, Abdullah A., Manda, Ana Laura, Manguerra, Helena, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mantilla Herrera, Ana M., Maravilla, Joemer C., Marks, Ashley, Martin, Randall V., Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Masoumi, Seyedeh Zahra, Mathur, Manu Raj, Matsushita, Kunihiro, Maulik, Pallab K., McAlinden, Colm, McGrath, John J., McKee, Martin, Mehndiratta, Man Mohan, Mehri, Fereshteh, Mehta, Kala M., Memish, Ziad A., Mendoza, Walter, Menezes, Ritesh G., Mengesha, Endalkachew Worku, Mereke, Alibek, Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J., Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Miller, Ted R., Mills, Edward J., Mini, G. K., Miri, Mohammad, Mirica, Andreea, Mirrakhimov, Erkin M., Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Mithra, Prasanna, Moazen, Babak, Mohammad, Dara K., Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadian-Hafshejani, Abdollah, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohammed, Ammas Siraj, Mohammed, Hussen, Mohammed, Jemal Abdu, Mohammed, Shafiu, Mokdad, Ali H., Molokhia, Mariam, Monasta, Lorenzo, Mooney, Meghan D., Moradi, Ghobad, Moradi, Masoud, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Morawska, Lidia, Morgado-da-Costa, Joana, Morrison, Shane Douglas, Mosapour, Abbas, Mosser, Jonathan F., Mouodi, Simin, Mousavi, Seyyed Meysam, Mousavi Khaneghah, Amin, Mueller, Ulrich Otto, Mukhopadhyay, Satinath, Mullany, Erin C., Musa, Kamarul Imran, Muthupandian, Saravanan, Nabhan, Ashraf F., Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Nagel, Gabriele, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naimzada, Mukhammad David, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Naserbakht, Morteza, Nayak, Vinod C., Negoi, Ionut, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nguyen, Minh, Nigatu, Yeshambel T., Nikbakhsh, Rajan, Nixon, Molly R., Nnaji, Chukwudi A., Nomura, Shuhei, Norrving, Bo, Noubiap, Jean Jacques, Nowak, Christoph, Nunez-Samudio, Virginia, Oţoiu, Adrian, Oancea, Bogdan, Odell, Christopher M., Ogbo, Felix Akpojene, Oh, In Hwan, Okunga, Emmanuel Wandera, Oladnabi, Morteza, Olagunju, Andrew T., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omer, Muktar Omer, Ong, Kanyin L., Onwujekwe, Obinna E., Orpana, Heather M., Ortiz, Alberto, Osarenotor, Osayomwanbo, Osei, Frank B., Ostroff, Samuel M., Otstavnov, Nikita, Otstavnov, Stanislav S., Øverland, Simon, Owolabi, Mayowa O., P A, Mahesh, Padubidri, Jagadish Rao, Palladino, Raffaele, Panda-Jonas, Songhomitra, Pandey, Anamika, Parry, Charles D.H., Pasovic, Maja, Pasupula, Deepak Kumar, Patel, Sangram Kishor, Pathak, Mona, Patten, Scott B., Patton, George C., Pazoki Toroudi, Hamidreza, Peden, Amy E., Pennini, Alyssa, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K., Pereira, David M., Pesudovs, Konrad, Pham, Hai Quang, Phillips, Michael R., Piccinelli, Cristiano, Pilz, Tessa M., Piradov, Michael A., Pirsaheb, Meghdad, Plass, Dietrich, Polinder, Suzanne, Polkinghorne, Kevan R., Pond, Constance Dimity, Postma, Maarten J., Pourjafar, Hadi, Pourmalek, Farshad, Poznańska, Anna, Prada, Sergio I., Prakash, V., Pribadi, Dimas Ria Angga, Pupillo, Elisabetta, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiee, Ata, Raggi, Alberto, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Rakovac, Ivo, Ram, Pradhum, Ramezanzadeh, Kiana, Ranabhat, Chhabi Lal, Rao, Puja C., Rao, Sowmya J., Rashedi, Vahid, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Rawat, Ramu, Razo, Christian, Redford, Sofia Boston, Reiner, Robert C., Reitsma, Marissa Bettay, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M.N., Resnikoff, Serge, Rezaei, Negar, Rezaei, Nima, Rezapour, Aziz, Rhinehart, Phoebe Anne, Riahi, Seyed Mohammad, Ribeiro, Daniel Cury, Ribeiro, Daniela, Rickard, Jennifer, Rivera, Juan A., Roberts, Nicholas L.S., Rodríguez-Ramírez, Sonia, Roever, Leonardo, Ronfani, Luca, Room, Robin, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Rubagotti, Enrico, Rwegerera, Godfrey M., Sabour, Siamak, Sachdev, Perminder S., Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeedi, Reza, Saeedi Moghaddam, Sahar, Safari, Yahya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sajadi, S. 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Elbarazi, Iffat, Elgendy, Islam Y., El-Jaafary, Shaimaa I., Elyazar, Iqbal RF, Emmons-Bell, Sophia, Erskine, Holly E., Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Estep, Kara, Etemadi, Arash, Etisso, Atkilt Esaiyas, Fanzo, Jessica, Farahmand, Mohammad, Fareed, Mohammad, Faridnia, Roghiyeh, Farioli, Andrea, Faro, Andre, Faruque, Mithila, Farzadfar, Farshad, Fattahi, Nazir, Fazlzadeh, Mehdi, Feigin, Valery L., Feldman, Rachel, Fereshtehnejad, Seyed Mohammad, Fernandes, Eduarda, Ferrara, Giannina, Ferrari, Alize J., Ferreira, Manuela L., Filip, Irina, Fischer, Florian, Fisher, James L., Flor, Luisa Sorio, Foigt, Nataliya A., Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Force, Lisa M., Foroutan, Masoud, Franklin, Richard Charles, Freitas, Marisa, Fu, Weijia, Fukumoto, Takeshi, Furtado, João M., Gad, Mohamed M., Gakidou, Emmanuela, Gallus, Silvano, Garcia-Basteiro, Alberto L., Gardner, William M., Geberemariyam, Biniyam Sahiledengle, Gebreslassie, Assefa Ayalew Ayalew Ayalew, Geremew, Abraham, Gershberg Hayoon, Anna, Gething, Peter W., Ghadimi, Maryam, Ghadiri, Keyghobad, Ghaffarifar, Fatemeh, Ghafourifard, Mansour, Ghamari, Farhad, Ghashghaee, Ahmad, Ghiasvand, Hesam, Ghith, Nermin, Gholamian, Asadollah, Ghosh, Rakesh, Gill, Paramjit Singh, Ginindza, Themba G.G., Giussani, Giorgia, Gnedovskaya, Elena V., Goharinezhad, Salime, Gopalani, Sameer Vali, Gorini, Giuseppe, Goudarzi, Houman, Goulart, Alessandra C., Greaves, Felix, Grivna, Michal, Grosso, Giuseppe, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Guimarães, Rafael Alves, Guled, Rashid Abdi, Guo, Gaorui, Guo, Yuming, Gupta, Rajeev, Gupta, Tarun, Haddock, Beatrix, Hafezi-Nejad, Nima, Hafiz, Abdul, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J., Halvaei, Iman, Hamadeh, Randah R., Hamidi, Samer, Hammer, Melanie S., Hankey, Graeme J., Haririan, Hamidreza, Haro, Josep Maria, Hasaballah, Ahmed I., Hasan, Md Mehedi, Hasanpoor, Edris, Hashi, Abdiwahab, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J., Hay, Simon I., Hayat, Khezar, Heidari, Golnaz, Heidari-Soureshjani, Reza, Henrikson, Hannah J., Herbert, Molly E., Herteliu, Claudiu, Heydarpour, Fatemeh, Hird, Thomas R., Hoek, Hans W., Holla, Ramesh, Hoogar, Praveen, Hosgood, H. Dean, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsairi, Mohamed, Hsieh, Vivian Chia rong, Hu, Guoqing, Hu, Kejia, Huda, Tanvir M., Humayun, Ayesha, Huynh, Chantal K., Hwang, Bing Fang, Iannucci, Vincent C., Ibitoye, Segun Emmanuel, Ikeda, Nayu, Ikuta, Kevin S., Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Inbaraj, Leeberk Raja, Ippolito, Helen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, M. 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Anil, Kumar, Vivek, Kurmi, Om P., Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lami, Faris Hasan, Landires, Iván, Lang, Justin J., Langan, Sinéad M., Larsson, Anders O., Lasrado, Savita, Lauriola, Paolo, Lazarus, Jeffrey V., Lee, Paul H., Lee, Shaun Wen Huey, LeGrand, Kate E., Leigh, James, Leonardi, Matilde, Lescinsky, Haley, Leung, Janni, Levi, Miriam, Li, Shanshan, Lim, Lee Ling, Linn, Shai, Liu, Shiwei, Liu, Simin, Liu, Yang, Lo, Justin, Lopez, Alan D., Lopez, Jaifred Christian F., Lopukhov, Platon D., Lorkowski, Stefan, Lotufo, Paulo A., Lu, Alton, Lugo, Alessandra, Maddison, Emilie R., Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Mahmoudi, Morteza, Majeed, Azeem, Maleki, Afshin, Maleki, Shokofeh, Malekzadeh, Reza, Malta, Deborah Carvalho, Mamun, Abdullah A., Manda, Ana Laura, Manguerra, Helena, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mantilla Herrera, Ana M., Maravilla, Joemer C., Marks, Ashley, Martin, Randall V., Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Masoumi, Seyedeh Zahra, Mathur, Manu Raj, Matsushita, Kunihiro, Maulik, Pallab K., McAlinden, Colm, McGrath, John J., McKee, Martin, Mehndiratta, Man Mohan, Mehri, Fereshteh, Mehta, Kala M., Memish, Ziad A., Mendoza, Walter, Menezes, Ritesh G., Mengesha, Endalkachew Worku, Mereke, Alibek, Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J., Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Miller, Ted R., Mills, Edward J., Mini, G. K., Miri, Mohammad, Mirica, Andreea, Mirrakhimov, Erkin M., Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Mithra, Prasanna, Moazen, Babak, Mohammad, Dara K., Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadian-Hafshejani, Abdollah, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohammed, Ammas Siraj, Mohammed, Hussen, Mohammed, Jemal Abdu, Mohammed, Shafiu, Mokdad, Ali H., Molokhia, Mariam, Monasta, Lorenzo, Mooney, Meghan D., Moradi, Ghobad, Moradi, Masoud, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Morawska, Lidia, Morgado-da-Costa, Joana, Morrison, Shane Douglas, Mosapour, Abbas, Mosser, Jonathan F., Mouodi, Simin, Mousavi, Seyyed Meysam, Mousavi Khaneghah, Amin, Mueller, Ulrich Otto, Mukhopadhyay, Satinath, Mullany, Erin C., Musa, Kamarul Imran, Muthupandian, Saravanan, Nabhan, Ashraf F., Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Nagel, Gabriele, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naimzada, Mukhammad David, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Naserbakht, Morteza, Nayak, Vinod C., Negoi, Ionut, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nguyen, Minh, Nigatu, Yeshambel T., Nikbakhsh, Rajan, Nixon, Molly R., Nnaji, Chukwudi A., Nomura, Shuhei, Norrving, Bo, Noubiap, Jean Jacques, Nowak, Christoph, Nunez-Samudio, Virginia, Oţoiu, Adrian, Oancea, Bogdan, Odell, Christopher M., Ogbo, Felix Akpojene, Oh, In Hwan, Okunga, Emmanuel Wandera, Oladnabi, Morteza, Olagunju, Andrew T., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omer, Muktar Omer, Ong, Kanyin L., Onwujekwe, Obinna E., Orpana, Heather M., Ortiz, Alberto, Osarenotor, Osayomwanbo, Osei, Frank B., Ostroff, Samuel M., Otstavnov, Nikita, Otstavnov, Stanislav S., Øverland, Simon, Owolabi, Mayowa O., P A, Mahesh, Padubidri, Jagadish Rao, Palladino, Raffaele, Panda-Jonas, Songhomitra, Pandey, Anamika, Parry, Charles D.H., Pasovic, Maja, Pasupula, Deepak Kumar, Patel, Sangram Kishor, Pathak, Mona, Patten, Scott B., Patton, George C., Pazoki Toroudi, Hamidreza, Peden, Amy E., Pennini, Alyssa, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K., Pereira, David M., Pesudovs, Konrad, Pham, Hai Quang, Phillips, Michael R., Piccinelli, Cristiano, Pilz, Tessa M., Piradov, Michael A., Pirsaheb, Meghdad, Plass, Dietrich, Polinder, Suzanne, Polkinghorne, Kevan R., Pond, Constance Dimity, Postma, Maarten J., Pourjafar, Hadi, Pourmalek, Farshad, Poznańska, Anna, Prada, Sergio I., Prakash, V., Pribadi, Dimas Ria Angga, Pupillo, Elisabetta, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiee, Ata, Raggi, Alberto, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Rakovac, Ivo, Ram, Pradhum, Ramezanzadeh, Kiana, Ranabhat, Chhabi Lal, Rao, Puja C., Rao, Sowmya J., Rashedi, Vahid, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Rawat, Ramu, Razo, Christian, Redford, Sofia Boston, Reiner, Robert C., Reitsma, Marissa Bettay, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M.N., Resnikoff, Serge, Rezaei, Negar, Rezaei, Nima, Rezapour, Aziz, Rhinehart, Phoebe Anne, Riahi, Seyed Mohammad, Ribeiro, Daniel Cury, Ribeiro, Daniela, Rickard, Jennifer, Rivera, Juan A., Roberts, Nicholas L.S., Rodríguez-Ramírez, Sonia, Roever, Leonardo, Ronfani, Luca, Room, Robin, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Rubagotti, Enrico, Rwegerera, Godfrey M., Sabour, Siamak, Sachdev, Perminder S., Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeedi, Reza, Saeedi Moghaddam, Sahar, Safari, Yahya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sajadi, S. 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Abstract

Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods: GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk–outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk–outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk–outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each

Published
2020

131. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Sub Foundations&PhilosophyofNaturSc begr, IRAS OH Epidemiology Chemical Agents, dIRAS RA-2, Murray, Christopher J.L., Aravkin, Aleksandr Y., Zheng, Peng, Abbafati, Cristiana, Abbas, Kaja M., Abbasi-Kangevari, Mohsen, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abegaz, Kedir Hussein, Abolhassani, Hassan, Aboyans, Victor, Abreu, Lucas Guimarães, Abrigo, Michael R.M., Abualhasan, Ahmed, Abu-Raddad, Laith Jamal, Abushouk, Abdelrahman I., Adabi, Maryam, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O., Adham, Davoud, Advani, Shailesh M., Agarwal, Gina, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Akalu, Temesgen Yihunie, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akombi, Blessing, Akunna, Chisom Joyqueenet, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Samiah, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M., Alemu, Biresaw wassihun, Alhabib, Khalid F., Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Almasi-Hashiani, Amir, Al-Mekhlafi, Hesham M., Alonso, Jordi, Altirkawi, Khalid A., Amini-Rarani, Mostafa, Amiri, Fatemeh, Amugsi, Dickson A., Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A., Andrei, Catalina Liliana, Andrei, Tudorel, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari-Moghaddam, Alireza, Antonazzo, Ippazio Cosimo, Antonio, Carl Abelardo T., Antony, Catherine M., Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Ariani, Filippo, Armoon, Bahram, Ärnlöv, Johan, Arzani, Afsaneh, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A., Ashbaugh, Charlie, Assmus, Michael, Atafar, Zahra, Atnafu, Desta Debalkie, Atout, Maha Moh d.Wahbi, Ausloos, Floriane, Ausloos, Marcel, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Badawi, Alaa, Badiye, Ashish D., Bahrami, Mohammad Amin, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M., Baldasseroni, Alberto, Ball, Kylie, Ballew, Shoshana H., Balzi, Daniela, Banach, Maciej, Banerjee, Srikanta K., Bante, Agegnehu Bante, Baraki, Adhanom Gebreegziabher, Barker-Collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H., Barthelemy, Celine M., Barua, Lingkan, Basu, Sanjay, Baune, Bernhard T., Bayati, Mohsen, Becker, Jacob S., Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bell, Michellr L., Bennitt, Fiona B., Bensenor, Isabela M., Berhe, Kidanemaryam, Berman, Adam E., Bhagavathula, Akshaya Srikanth, Bhageerathy, Reshmi, Bhala, Neeraj, Bhandari, Dinesh, Bhattacharyya, Krittika, Bhutta, Zulfiqar A., Bijani, Ali, Bikbov, Boris, Bin Sayeed, Muhammad Shahdaat, Biondi, Antonio, Birihane, Binyam Minuye, Bisignano, Catherine, Biswas, Raaj Kishore, Bitew, Helen, Bohlouli, Somayeh, Bohluli, Mehdi, Boon-Dooley, Alexandra S., Borges, Guilherme, Borzì, Antonio Maria, Borzouei, Shiva, Bosetti, Cristina, Boufous, Soufiane, Braithwaite, Dejana, Breitborde, Nicholas J.K., Breitner, Susanne, Brenner, Hermann, Briant, Paul Svitil, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle B., Bryazka, Dana, Bumgarner, Blair R., Burkart, Katrin, Burnett, Richard Thomas, Burugina Nagaraja, Sharath, Butt, Zahid A., Caetano dos Santos, Florentino Luciano, Cahill, Leah E., Cámera, Luis LA Alberto, Campos-Nonato, Ismael R., Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J., Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castañeda-Orjuela, Carlos A., Castelpietra, Giulio, Castro, Franz, Causey, Kate, Cederroth, Christopher R., Cercy, Kelly M., Cerin, Ester, Chandan, Joht Singh, Chang, Kai Lan, Charlson, Fiona J., Chattu, Vijay Kumar, Chaturvedi, Sarika, Cherbuin, Nicolas, Chimed-Ochir, Odgerel, Cho, Daniel Youngwhan, Choi, Jee Young Jasmine, Christensen, Hanne, Chu, Dinh Toi, Chung, Michael T., Chung, Sheng Chia, Cicuttini, Flavia M., Ciobanu, Liliana G., Cirillo, Massimo, Classen, Thomas Khaled Dwayne, Cohen, Aaron J., Compton, Kelly, Cooper, Owen R., Costa, Vera Marisa, Cousin, Ewerton, Cowden, Richard G., Cross, Di H., Cruz, Jessica A., Dahlawi, Saad M.A., Damasceno, Albertino Antonio Moura, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Dangel, William James, Danielsson, Anna Karin, Dargan, Paul I., Darwesh, Aso Mohammad, Daryani, Ahmad, Das, Jai K., Das Gupta, Rajat, das Neves, José, Dávila-Cervantes, Claudio Alberto, Davitoiu, Dragos Virgil, De Leo, Diego, Degenhardt, Louisa, DeLang, Marissa, Dellavalle, Robert Paul, Demeke, Feleke Mekonnen, Demoz, Gebre Teklemariam, Demsie, Desalegn Getnet, Denova-Gutiérrez, Edgar, Dervenis, Nikolaos, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, Dias da Silva, Diana, Diaz, Daniel, Dibaji Forooshani, Zahra Sadat, Djalalinia, Shirin, Do, Hoa Thi, Dokova, Klara, Dorostkar, Fariba, Doshmangir, Leila, Driscoll, Tim Robert, Duncan, Bruce B., Duraes, Andre Rodrigues, Eagan, Arielle Wilder, Edvardsson, David, El Nahas, Nevine, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, Elgendy, Islam Y., El-Jaafary, Shaimaa I., Elyazar, Iqbal RF, Emmons-Bell, Sophia, Erskine, Holly E., Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esteghamati, Alireza, Estep, Kara, Etemadi, Arash, Etisso, Atkilt Esaiyas, Fanzo, Jessica, Farahmand, Mohammad, Fareed, Mohammad, Faridnia, Roghiyeh, Farioli, Andrea, Faro, Andre, Faruque, Mithila, Farzadfar, Farshad, Fattahi, Nazir, Fazlzadeh, Mehdi, Feigin, Valery L., Feldman, Rachel, Fereshtehnejad, Seyed Mohammad, Fernandes, Eduarda, Ferrara, Giannina, Ferrari, Alize J., Ferreira, Manuela L., Filip, Irina, Fischer, Florian, Fisher, James L., Flor, Luisa Sorio, Foigt, Nataliya A., Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Force, Lisa M., Foroutan, Masoud, Franklin, Richard Charles, Freitas, Marisa, Fu, Weijia, Fukumoto, Takeshi, Furtado, João M., Gad, Mohamed M., Gakidou, Emmanuela, Gallus, Silvano, Garcia-Basteiro, Alberto L., Gardner, William M., Geberemariyam, Biniyam Sahiledengle, Gebreslassie, Assefa Ayalew Ayalew Ayalew, Geremew, Abraham, Gershberg Hayoon, Anna, Gething, Peter W., Ghadimi, Maryam, Ghadiri, Keyghobad, Ghaffarifar, Fatemeh, Ghafourifard, Mansour, Ghamari, Farhad, Ghashghaee, Ahmad, Ghiasvand, Hesam, Ghith, Nermin, Gholamian, Asadollah, Ghosh, Rakesh, Gill, Paramjit Singh, Ginindza, Themba G.G., Giussani, Giorgia, Gnedovskaya, Elena V., Goharinezhad, Salime, Gopalani, Sameer Vali, Gorini, Giuseppe, Goudarzi, Houman, Goulart, Alessandra C., Greaves, Felix, Grivna, Michal, Grosso, Giuseppe, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Guimarães, Rafael Alves, Guled, Rashid Abdi, Guo, Gaorui, Guo, Yuming, Gupta, Rajeev, Gupta, Tarun, Haddock, Beatrix, Hafezi-Nejad, Nima, Hafiz, Abdul, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J., Halvaei, Iman, Hamadeh, Randah R., Hamidi, Samer, Hammer, Melanie S., Hankey, Graeme J., Haririan, Hamidreza, Haro, Josep Maria, Hasaballah, Ahmed I., Hasan, Md Mehedi, Hasanpoor, Edris, Hashi, Abdiwahab, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J., Hay, Simon I., Hayat, Khezar, Heidari, Golnaz, Heidari-Soureshjani, Reza, Henrikson, Hannah J., Herbert, Molly E., Herteliu, Claudiu, Heydarpour, Fatemeh, Hird, Thomas R., Hoek, Hans W., Holla, Ramesh, Hoogar, Praveen, Hosgood, H. 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William M., Geberemariyam, Biniyam Sahiledengle, Gebreslassie, Assefa Ayalew Ayalew Ayalew, Geremew, Abraham, Gershberg Hayoon, Anna, Gething, Peter W., Ghadimi, Maryam, Ghadiri, Keyghobad, Ghaffarifar, Fatemeh, Ghafourifard, Mansour, Ghamari, Farhad, Ghashghaee, Ahmad, Ghiasvand, Hesam, Ghith, Nermin, Gholamian, Asadollah, Ghosh, Rakesh, Gill, Paramjit Singh, Ginindza, Themba G.G., Giussani, Giorgia, Gnedovskaya, Elena V., Goharinezhad, Salime, Gopalani, Sameer Vali, Gorini, Giuseppe, Goudarzi, Houman, Goulart, Alessandra C., Greaves, Felix, Grivna, Michal, Grosso, Giuseppe, Gubari, Mohammed Ibrahim Mohialdeen, Gugnani, Harish Chander, Guimarães, Rafael Alves, Guled, Rashid Abdi, Guo, Gaorui, Guo, Yuming, Gupta, Rajeev, Gupta, Tarun, Haddock, Beatrix, Hafezi-Nejad, Nima, Hafiz, Abdul, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J., Halvaei, Iman, Hamadeh, Randah R., Hamidi, Samer, Hammer, Melanie S., Hankey, Graeme J., Haririan, Hamidreza, Haro, Josep Maria, Hasaballah, Ahmed I., Hasan, Md Mehedi, Hasanpoor, Edris, Hashi, Abdiwahab, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J., Hay, Simon I., Hayat, Khezar, Heidari, Golnaz, Heidari-Soureshjani, Reza, Henrikson, Hannah J., Herbert, Molly E., Herteliu, Claudiu, Heydarpour, Fatemeh, Hird, Thomas R., Hoek, Hans W., Holla, Ramesh, Hoogar, Praveen, Hosgood, H. Dean, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hsairi, Mohamed, Hsieh, Vivian Chia rong, Hu, Guoqing, Hu, Kejia, Huda, Tanvir M., Humayun, Ayesha, Huynh, Chantal K., Hwang, Bing Fang, Iannucci, Vincent C., Ibitoye, Segun Emmanuel, Ikeda, Nayu, Ikuta, Kevin S., Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Inbaraj, Leeberk Raja, Ippolito, Helen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, M. Mofizul, Islam, Sheikh Mohammed Shariful, Iso, Hiroyasu, Ivers, Rebecca Q., Iwu, Chidozie C.D., Iwu, Chinwe Juliana, Iyamu, Ihoghosa Osamuyi, Jaafari, Jalil, Jacobsen, Kathryn H., Jafari, Hussain, Jafarinia, Morteza, Jahani, Mohammad Ali, Jakovljevic, Mihajlo, Jalilian, Farzad, James, Spencer L., Janjani, Hosna, Javaheri, Tahereh, Javidnia, Javad, Jeemon, Panniyammakal, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S., Johansson, Lars, John, Oommen, John-Akinola, Yetunde O., Johnson, Catherine Owens, Jonas, Jost B., Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jürisson, Mikk, Kabir, Ali, Kabir, Zubair, Kalani, Hamed, Kalani, Rizwan, Kalankesh, Leila R., Kalhor, Rohollah, Kanchan, Tanuj, Kapoor, Neeti, Karami Matin, Behzad, Karch, André, Karim, Mohd Anisul, Kassa, Getachew Mullu, Katikireddi, Srinivasa Vittal, Kayode, Gbenga A., Kazemi Karyani, Ali, Keiyoro, Peter Njenga, Keller, Cathleen, Kemmer, Laura, Kendrick, Parkes J., Khalid, Nauman, Khammarnia, Mohammad, Khan, Ejaz Ahmad, Khan, Maseer, Khatab, Khaled, Khater, Mona M., Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khazaei, Salman, Kieling, Christian, Kim, Yun Jin, Kimokoti, Ruth W., Kisa, Adnan, Kisa, Sezer, Kivimäki, Mika, Knibbs, Luke D., Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M., Kochhar, Sonali, Kopec, Jacek A., Korshunov, Vladimir Andreevich, Koul, Parvaiz A., Koyanagi, Ai, Kraemer, Moritz U.G., Krishan, Kewal, Krohn, Kris J., Kromhout, Hans, Kuate Defo, Barthelemy, Kumar, G. Anil, Kumar, Vivek, Kurmi, Om P., Kusuma, Dian, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lami, Faris Hasan, Landires, Iván, Lang, Justin J., Langan, Sinéad M., Larsson, Anders O., Lasrado, Savita, Lauriola, Paolo, Lazarus, Jeffrey V., Lee, Paul H., Lee, Shaun Wen Huey, LeGrand, Kate E., Leigh, James, Leonardi, Matilde, Lescinsky, Haley, Leung, Janni, Levi, Miriam, Li, Shanshan, Lim, Lee Ling, Linn, Shai, Liu, Shiwei, Liu, Simin, Liu, Yang, Lo, Justin, Lopez, Alan D., Lopez, Jaifred Christian F., Lopukhov, Platon D., Lorkowski, Stefan, Lotufo, Paulo A., Lu, Alton, Lugo, Alessandra, Maddison, Emilie R., Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Mahmoudi, Morteza, Majeed, Azeem, Maleki, Afshin, Maleki, Shokofeh, Malekzadeh, Reza, Malta, Deborah Carvalho, Mamun, Abdullah A., Manda, Ana Laura, Manguerra, Helena, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Mantilla Herrera, Ana M., Maravilla, Joemer C., Marks, Ashley, Martin, Randall V., Martini, Santi, Martins-Melo, Francisco Rogerlândio, Masaka, Anthony, Masoumi, Seyedeh Zahra, Mathur, Manu Raj, Matsushita, Kunihiro, Maulik, Pallab K., McAlinden, Colm, McGrath, John J., McKee, Martin, Mehndiratta, Man Mohan, Mehri, Fereshteh, Mehta, Kala M., Memish, Ziad A., Mendoza, Walter, Menezes, Ritesh G., Mengesha, Endalkachew Worku, Mereke, Alibek, Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J., Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Miller, Ted R., Mills, Edward J., Mini, G. K., Miri, Mohammad, Mirica, Andreea, Mirrakhimov, Erkin M., Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Mithra, Prasanna, Moazen, Babak, Mohammad, Dara K., Mohammad, Yousef, Mohammad Gholi Mezerji, Naser, Mohammadian-Hafshejani, Abdollah, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohammed, Ammas Siraj, Mohammed, Hussen, Mohammed, Jemal Abdu, Mohammed, Shafiu, Mokdad, Ali H., Molokhia, Mariam, Monasta, Lorenzo, Mooney, Meghan D., Moradi, Ghobad, Moradi, Masoud, Moradi-Lakeh, Maziar, Moradzadeh, Rahmatollah, Moraga, Paula, Morawska, Lidia, Morgado-da-Costa, Joana, Morrison, Shane Douglas, Mosapour, Abbas, Mosser, Jonathan F., Mouodi, Simin, Mousavi, Seyyed Meysam, Mousavi Khaneghah, Amin, Mueller, Ulrich Otto, Mukhopadhyay, Satinath, Mullany, Erin C., Musa, Kamarul Imran, Muthupandian, Saravanan, Nabhan, Ashraf F., Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Nagel, Gabriele, Naghavi, Mohsen, Naghshtabrizi, Behshad, Naimzada, Mukhammad David, Najafi, Farid, Nangia, Vinay, Nansseu, Jobert Richie, Naserbakht, Morteza, Nayak, Vinod C., Negoi, Ionut, Ngunjiri, Josephine W., Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nguyen, Minh, Nigatu, Yeshambel T., Nikbakhsh, Rajan, Nixon, Molly R., Nnaji, Chukwudi A., Nomura, Shuhei, Norrving, Bo, Noubiap, Jean Jacques, Nowak, Christoph, Nunez-Samudio, Virginia, Oţoiu, Adrian, Oancea, Bogdan, Odell, Christopher M., Ogbo, Felix Akpojene, Oh, In Hwan, Okunga, Emmanuel Wandera, Oladnabi, Morteza, Olagunju, Andrew T., Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Omer, Muktar Omer, Ong, Kanyin L., Onwujekwe, Obinna E., Orpana, Heather M., Ortiz, Alberto, Osarenotor, Osayomwanbo, Osei, Frank B., Ostroff, Samuel M., Otstavnov, Nikita, Otstavnov, Stanislav S., Øverland, Simon, Owolabi, Mayowa O., P A, Mahesh, Padubidri, Jagadish Rao, Palladino, Raffaele, Panda-Jonas, Songhomitra, Pandey, Anamika, Parry, Charles D.H., Pasovic, Maja, Pasupula, Deepak Kumar, Patel, Sangram Kishor, Pathak, Mona, Patten, Scott B., Patton, George C., Pazoki Toroudi, Hamidreza, Peden, Amy E., Pennini, Alyssa, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K., Pereira, David M., Pesudovs, Konrad, Pham, Hai Quang, Phillips, Michael R., Piccinelli, Cristiano, Pilz, Tessa M., Piradov, Michael A., Pirsaheb, Meghdad, Plass, Dietrich, Polinder, Suzanne, Polkinghorne, Kevan R., Pond, Constance Dimity, Postma, Maarten J., Pourjafar, Hadi, Pourmalek, Farshad, Poznańska, Anna, Prada, Sergio I., Prakash, V., Pribadi, Dimas Ria Angga, Pupillo, Elisabetta, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiee, Ata, Raggi, Alberto, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Rakovac, Ivo, Ram, Pradhum, Ramezanzadeh, Kiana, Ranabhat, Chhabi Lal, Rao, Puja C., Rao, Sowmya J., Rashedi, Vahid, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Rawat, Ramu, Razo, Christian, Redford, Sofia Boston, Reiner, Robert C., Reitsma, Marissa Bettay, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M.N., Resnikoff, Serge, Rezaei, Negar, Rezaei, Nima, Rezapour, Aziz, Rhinehart, Phoebe Anne, Riahi, Seyed Mohammad, Ribeiro, Daniel Cury, Ribeiro, Daniela, Rickard, Jennifer, Rivera, Juan A., Roberts, Nicholas L.S., Rodríguez-Ramírez, Sonia, Roever, Leonardo, Ronfani, Luca, Room, Robin, Roshandel, Gholamreza, Roth, Gregory A., Rothenbacher, Dietrich, Rubagotti, Enrico, Rwegerera, Godfrey M., Sabour, Siamak, Sachdev, Perminder S., Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeedi, Reza, Saeedi Moghaddam, Sahar, Safari, Yahya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sajadi, S. Mohammad, Salam, Nasir, Salamati, Payman, Salem, Hosni, Salem, Marwa R.Rashad, Salimzadeh, Hamideh, Salman, Omar Mukhtar, Salomon, Joshua A., Samad, Zainab, Samadi Kafil, Hossein, Sambala, Evanson Zondani, Samy, Abdallah M., Sanabria, Juan, Sánchez-Pimienta, Tania G., Santomauro, Damian Francesco, Santos, Itamar S., Santos, João Vasco, Santric-Milicevic, Milena M., Saraswathy, Sivan Yegnanarayana Iyer, Sarmiento-Suárez, Rodrigo, Sarrafzadegan, Nizal, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Saxena, Sonia, Schaeffer, Lauren E., Schiavolin, Silvia, Schlaich, Markus P., Schmidt, Maria Inês, Schutte, Aletta Elisabeth, Schwebel, David C., Schwendicke, Falk, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Sepanlou, Sadaf G., Serdar, Berrin, Serre, Marc L., Shadid, Jamileh, Shafaat, Omid, Shahabi, Saeed, Shaheen, Amira A., Shaikh, Masood Ali, Shalash, Ali S., Shams-Beyranvand, Mehran, Shamsizadeh, Morteza, Sharafi, Kiomars, Sheikh, Aziz, Sheikhtaheri, Abbas, Shibuya, Kenji, Shield, Kevin David, Shigematsu, Mika, Shin, Jae Il, Shin, Min Jeong, Shiri, Rahman, Shirkoohi, Reza, Shuval, Kerem, Siabani, Soraya, Sierpinski, Radoslaw, Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silva, João Pedro, Simpson, Kyle E., Singh, Jasvinder A., Singh, Pushpendra, Skiadaresi, Eirini, Skou, Søren T.Skou, Skryabin, Valentin Yurievich, Smith, Emma U.R., Soheili, Amin, Soltani, Shahin, Soofi, Moslem, Sorensen, Reed J.D., Soriano, Joan B., Sorrie, Muluken Bekele, Soshnikov, Sergey, Soyiri, Ireneous N., Spencer, Cory N., Spotin, Adel, Sreeramareddy, Chandrashekhar T., Srinivasan, Vinay, Stanaway, Jeffrey D., Stein, Caroline, Stein, Dan J., Steiner, Caitlyn, Stockfelt, Leo, Stokes, Mark A., Straif, Kurt, Stubbs, Jacob L., Sufiyan, Mu'awiyyah Babale, Suleria, Hafiz Ansar Rasul, Suliankatchi Abdulkader, Rizwan, Sulo, Gerhard, Sultan, Iyad, Szumowski, Łukasz, Tabarés-Seisdedos, Rafael, Tabb, Karen M., Tabuchi, Takahiro, Taherkhani, Amir, Tajdini, Masih, Takahashi, Ken, Takala, Jukka S., Tamiru, Animut Tagele, Taveira, Nuno, Tehrani-Banihashemi, Arash, Temsah, Mohamad Hani, Tesema, Getayeneh Antehunegn, Tessema, Zemenu Tadesse, Thurston, George D., Titova, Mariya Vladimirovna, Tohidinik, Hamid Reza, Tonelli, Marcello, Topor-Madry, Roman, Topouzis, Fotis, Torre, Anna E., Touvier, Mathilde, Tovani-Palone, Marcos Roberto Roberto, Tran, Bach Xuan, Travillian, Ravensara, Tsatsakis, Aristidis, Tudor Car, Lorainne, Tyrovolas, Stefanos, Uddin, Riaz, Umeokonkwo, Chukwuma David, Unnikrishnan, Bhaskaran, Upadhyay, Era, Vacante, Marco, Valdez, Pascual R., van Donkelaar, Aaron, Vasankari, Tommi Juhani, Vasseghian, Yasser, Veisani, Yousef, Venketasubramanian, Narayanaswamy, Violante, Francesco S., Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Vukovic, Rade, Waheed, Yasir, Wallin, Mitchell Taylor, Wang, Yafeng, Wang, Yuan Pang, Watson, Alexandrea, Wei, Jingkai, Wei, Melissa Y.Wei, Weintraub, Robert G., Weiss, Jordan, Werdecker, Andrea, West, J. Jason, Westerman, Ronny, Whisnant, Joanna L., Whiteford, Harvey A., Wiens, Kirsten E., Wolfe, Charles D.A., Wozniak, Sarah S., Wu, Ai Min, Wu, Junjie, Wulf Hanson, Sarah, Xu, Gelin, Xu, Rixing, Yadgir, Simon, Yahyazadeh Jabbari, Seyed Hossein, Yamagishi, Kazumasa, Yaminfirooz, Mousa, Yano, Yuichiro, Yaya, Sanni, Yazdi-Feyzabadi, Vahid, Yeheyis, Tomas Y., Yilgwan, Christopher Sabo, Yilma, Mekdes Tigistu, Yip, Paul, Yonemoto, Naohiro, Younis, Mustafa Z., Younker, Theodore Patrick, Yousefi, Bahman, Yousefi, Zabihollah, Yousefinezhadi, Taraneh, Yousuf, Abdilahi Yousuf, Yu, Chuanhua, Yusefzadeh, Hasan, Zahirian Moghadam, Telma, Zamani, Mohammad, Zamanian, Maryam, Zandian, Hamed, Zastrozhin, Mikhail Sergeevich, Zhang, Yunquan, Zhang, Zhi Jiang, Zhao, Jeff T., Zhao, Xiu Ju George, Zhao, Yingxi, Zhou, Maigeng, Ziapour, Arash, Zimsen, Stephanie R.M., Brauer, Michael, Afshin, Ashkan, and Lim, Stephen S.

Published
2020

132. Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019

Author

Murray, Christopher J L, Aravkin, Aleksandr Y, Zheng, Peng, Abbafati, Cristiana, Abbas, Kaja M., Abbasi-Kangevari, Mohsen, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abegaz, Kedir Hussein, Abolhassani, Hassan, Aboyans, Victor, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abualhasan, Ahmed, Abu-raddad, Laith Jamal, Abushouk, Abdelrahman I, Adabi, Maryam, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O, Adham, Davoud, Advani, Shailesh M, Agarwal, Gina, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Akalu, Temesgen Yihunie, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akombi, Blessing, Akunna, Chisom Joyqueenet, Alahdab, Fares, Al-aly, Ziyad, Alam, Khurshid, Alam, Samiah, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alemu, Biresaw Wassihun, Alhabib, Khalid F, Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Almasi-hashiani, Amir, Al-mekhlafi, Hesham M, Alonso, Jordi, Altirkawi, Khalid A, Amini-rarani, Mostafa, Amiri, Fatemeh, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A, Andrei, Catalina Liliana, Andrei, Tudorel, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari-moghaddam, Alireza, Antonazzo, Ippazio Cosimo, Antonio, Carl Abelardo T, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-zozani, Morteza, Ariani, Filippo, Armoon, Bahram, Ärnlöv, Johan, Arzani, Afsaneh, Asadi-aliabadi, Mehran, Asadi-pooya, Ali A, Ashbaugh, Charlie, Assmus, Michael, Atafar, Zahra, Atnafu, Desta Debalkie, Atout, Maha Moh'd Wahbi, Ausloos, Floriane, Ausloos, Marcel, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Badawi, Alaa, Badiye, Ashish D, Bahrami, Mohammad Amin, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M, Baldasseroni, Alberto, Ball, Kylie, Ballew, Shoshana H, Balzi, Daniela, Banach, Maciej, Banerjee, Srikanta K, Bante, Agegnehu Bante, Baraki, Adhanom Gebreegziabher, Barker-collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H, Barthelemy, Celine M, Barua, Lingkan, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Becker, Jacob S, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bell, Michellr L, Bennitt, Fiona B, Bensenor, Isabela M, Berhe, Kidanemaryam, Berman, Adam E, Bhagavathula, Akshaya Srikanth, Bhageerathy, Reshmi, Bhala, Neeraj, Bhandari, Dinesh, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Bijani, Ali, Bikbov, Boris, Bin Sayeed, Muhammad Shahdaat, Biondi, Antonio, Birihane, Binyam Minuye, Bisignano, Catherine, Biswas, Raaj Kishore, Bitew, Helen, Bohlouli, Somayeh, Bohluli, Mehdi, Boon-dooley, Alexandra S, Borges, Guilherme, Borzì, Antonio Maria, Borzouei, Shiva, Bosetti, Cristina, Boufous, Soufiane, Braithwaite, Dejana, Breitborde, Nicholas J K, Breitner, Susanne, Brenner, Hermann, Briant, Paul Svitil, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle B, Bryazka, Dana, Bumgarner, Blair R, Burkart, Katrin, Burnett, Richard Thomas, Burugina Nagaraja, Sharath, Butt, Zahid A, Caetano Dos Santos, Florentino Luciano, Cahill, Leah E, Cámera, Luis La Alberto, Campos-nonato, Ismael R, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-maia, Joao Mauricio, Castañeda-orjuela, Carlos A, Castelpietra, Giulio, Castro, Franz, Causey, Kate, Cederroth, Christopher R, Cercy, Kelly M, Cerin, Ester, Chandan, Joht Singh, Chang, Kai-lan, Charlson, Fiona J, Chattu, Vijay Kumar, Chaturvedi, Sarika, Cherbuin, Nicolas, Chimed-ochir, Odgerel, Cho, Daniel Youngwhan, Choi, Jee-young Jasmine, Christensen, Hanne, Chu, Dinh-toi, Chung, Michael T, Chung, Sheng-chia, Cicuttini, Flavia M, Ciobanu, Liliana G, Cirillo, Massimo, Classen, Thomas Khaled Dwayne, Cohen, Aaron J, Compton, Kelly, Cooper, Owen R, Costa, Vera Marisa, Cousin, Ewerton, Cowden, Richard G, Cross, Di H, Cruz, Jessica A, Dahlawi, Saad M A, Damasceno, Albertino Antonio Moura, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Dangel, William James, Danielsson, Anna-karin, Dargan, Paul I, Darwesh, Aso Mohammad, Daryani, Ahmad, Das, Jai K, Das Gupta, Rajat, Das Neves, José, Dávila-cervantes, Claudio Alberto, Davitoiu, Dragos Virgil, De Leo, Diego, Degenhardt, Louisa, Delang, Marissa, Dellavalle, Robert Paul, Demeke, Feleke Mekonnen, Demoz, Gebre Teklemariam, Demsie, Desalegn Getnet, Denova-gutiérrez, Edgar, Dervenis, Nikolaos, Do, Hoa Thi, Franklin, Richard Charles, Guo, Yuming, Hasan, Md Mehedi, Johnson, Catherine Owens, Knibbs, Luke D, Leung, Janni, Li, Shanshan, Lim, Lee-ling, Liu, Yang, Morawska, Lidia, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nguyen, Minh, Rahman, Muhammad Aziz, Renzaho, Andre M N, Smith, Emma U R, Tonelli, Marcello, Wang, Yuan-pang, other, and, Murray, Christopher J L, Aravkin, Aleksandr Y, Zheng, Peng, Abbafati, Cristiana, Abbas, Kaja M., Abbasi-Kangevari, Mohsen, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abegaz, Kedir Hussein, Abolhassani, Hassan, Aboyans, Victor, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abualhasan, Ahmed, Abu-raddad, Laith Jamal, Abushouk, Abdelrahman I, Adabi, Maryam, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O, Adham, Davoud, Advani, Shailesh M, Agarwal, Gina, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Akalu, Temesgen Yihunie, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akombi, Blessing, Akunna, Chisom Joyqueenet, Alahdab, Fares, Al-aly, Ziyad, Alam, Khurshid, Alam, Samiah, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alemu, Biresaw Wassihun, Alhabib, Khalid F, Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Alla, François, Allebeck, Peter, Almasi-hashiani, Amir, Al-mekhlafi, Hesham M, Alonso, Jordi, Altirkawi, Khalid A, Amini-rarani, Mostafa, Amiri, Fatemeh, Amugsi, Dickson A, Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A, Andrei, Catalina Liliana, Andrei, Tudorel, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari-moghaddam, Alireza, Antonazzo, Ippazio Cosimo, Antonio, Carl Abelardo T, Antony, Catherine M, Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-zozani, Morteza, Ariani, Filippo, Armoon, Bahram, Ärnlöv, Johan, Arzani, Afsaneh, Asadi-aliabadi, Mehran, Asadi-pooya, Ali A, Ashbaugh, Charlie, Assmus, Michael, Atafar, Zahra, Atnafu, Desta Debalkie, Atout, Maha Moh'd Wahbi, Ausloos, Floriane, Ausloos, Marcel, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Badawi, Alaa, Badiye, Ashish D, Bahrami, Mohammad Amin, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M, Baldasseroni, Alberto, Ball, Kylie, Ballew, Shoshana H, Balzi, Daniela, Banach, Maciej, Banerjee, Srikanta K, Bante, Agegnehu Bante, Baraki, Adhanom Gebreegziabher, Barker-collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barrero, Lope H, Barthelemy, Celine M, Barua, Lingkan, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Becker, Jacob S, Bedi, Neeraj, Beghi, Ettore, Béjot, Yannick, Bell, Michellr L, Bennitt, Fiona B, Bensenor, Isabela M, Berhe, Kidanemaryam, Berman, Adam E, Bhagavathula, Akshaya Srikanth, Bhageerathy, Reshmi, Bhala, Neeraj, Bhandari, Dinesh, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Bijani, Ali, Bikbov, Boris, Bin Sayeed, Muhammad Shahdaat, Biondi, Antonio, Birihane, Binyam Minuye, Bisignano, Catherine, Biswas, Raaj Kishore, Bitew, Helen, Bohlouli, Somayeh, Bohluli, Mehdi, Boon-dooley, Alexandra S, Borges, Guilherme, Borzì, Antonio Maria, Borzouei, Shiva, Bosetti, Cristina, Boufous, Soufiane, Braithwaite, Dejana, Breitborde, Nicholas J K, Breitner, Susanne, Brenner, Hermann, Briant, Paul Svitil, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle B, Bryazka, Dana, Bumgarner, Blair R, Burkart, Katrin, Burnett, Richard Thomas, Burugina Nagaraja, Sharath, Butt, Zahid A, Caetano Dos Santos, Florentino Luciano, Cahill, Leah E, Cámera, Luis La Alberto, Campos-nonato, Ismael R, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-maia, Joao Mauricio, Castañeda-orjuela, Carlos A, Castelpietra, Giulio, Castro, Franz, Causey, Kate, Cederroth, Christopher R, Cercy, Kelly M, Cerin, Ester, Chandan, Joht Singh, Chang, Kai-lan, Charlson, Fiona J, Chattu, Vijay Kumar, Chaturvedi, Sarika, Cherbuin, Nicolas, Chimed-ochir, Odgerel, Cho, Daniel Youngwhan, Choi, Jee-young Jasmine, Christensen, Hanne, Chu, Dinh-toi, Chung, Michael T, Chung, Sheng-chia, Cicuttini, Flavia M, Ciobanu, Liliana G, Cirillo, Massimo, Classen, Thomas Khaled Dwayne, Cohen, Aaron J, Compton, Kelly, Cooper, Owen R, Costa, Vera Marisa, Cousin, Ewerton, Cowden, Richard G, Cross, Di H, Cruz, Jessica A, Dahlawi, Saad M A, Damasceno, Albertino Antonio Moura, Damiani, Giovanni, Dandona, Lalit, Dandona, Rakhi, Dangel, William James, Danielsson, Anna-karin, Dargan, Paul I, Darwesh, Aso Mohammad, Daryani, Ahmad, Das, Jai K, Das Gupta, Rajat, Das Neves, José, Dávila-cervantes, Claudio Alberto, Davitoiu, Dragos Virgil, De Leo, Diego, Degenhardt, Louisa, Delang, Marissa, Dellavalle, Robert Paul, Demeke, Feleke Mekonnen, Demoz, Gebre Teklemariam, Demsie, Desalegn Getnet, Denova-gutiérrez, Edgar, Dervenis, Nikolaos, Do, Hoa Thi, Franklin, Richard Charles, Guo, Yuming, Hasan, Md Mehedi, Johnson, Catherine Owens, Knibbs, Luke D, Leung, Janni, Li, Shanshan, Lim, Lee-ling, Liu, Yang, Morawska, Lidia, Nguyen, Cuong Tat, Nguyen, Huong Lan Thi, Nguyen, Minh, Rahman, Muhammad Aziz, Renzaho, Andre M N, Smith, Emma U R, Tonelli, Marcello, Wang, Yuan-pang, and other, and

Abstract

Background Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk–outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk–outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk–outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome qua

Published
2020

133. Global age-sex-specific fertility, mortality, healthy life expectancy (HALE), and population estimates in 204 countries and territories, 1950–2019: a comprehensive demographic analysis for the Global Burden of Disease Study 2019

Author

Wang, Haidong, Abbas, Kaja M, Abbasifard, Mitra, Abbasi-kangevari, Mohsen, Abbastabar, Hedayat, Abd-allah, Foad, Abdelalim, Ahmed, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abushouk, Abdelrahman I, Adabi, Maryam, Adair, Tim, Adebayo, Oladimeji M, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O, Advani, Shailesh M, Afshin, Ashkan, Aghaali, Mohammad, Agrawal, Anurag, Ahmadi, Keivan, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Al-aly, Ziyad, Alam, Khurshid, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alcalde-rabanal, Jacqueline Elizabeth, Ali, Muhammad, Alicandro, Gianfranco, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Allebeck, Peter, Almadi, Majid Abdulrahman Hamad, Almasi-hashiani, Amir, Al-mekhlafi, Hesham M, Altirkawi, Khalid A, Alumran, Arwa Khalid, Alvis-guzman, Nelson, Amini-rarani, Mostafa, Aminorroaya, Arya, Amit, Arianna Maever L, Ancuceanu, Robert, Andrei, Catalina Liliana, Androudi, Sofia, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari, Iman, Ansari-moghaddam, Alireza, Antonio, Carl Abelardo T, Antony, Catherine M, Anvari, Davood, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-zozani, Morteza, Aravkin, Aleksandr Y, Aremu, Olatunde, Ärnlöv, Johan, Aryal, Krishna K, Asadi-pooya, Ali A, Asgari, Samaneh, Asghari Jafarabadi, Mohammad, Atteraya, Madhu Sudhan, Ausloos, Marcel, Avila-burgos, Leticia, Avokpaho, Euripide Frinel Gbenato Arthur, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Azarian, Ghasem, Babaee, Ebrahim, Badiye, Ashish D, Bagli, Eleni, Bahrami, Mohammad Amin, Bakhtiari, Ahad, Balassyano, Shelly, Banach, Maciej, Banik, Palash Chandra, Barker-collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barzegar, Akbar, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Bazmandegan, Gholamreza, Bedi, Neeraj, Bell, Michellr L, Bennett, Derrick A, Bensenor, Isabela M, Berhe, Kidanemaryam, Berman, Adam E, Bertolacci, Gregory J, Bhageerathy, Reshmi, Bhala, Neeraj, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Bijani, Ali, Biondi, Antonio, Bisanzio, Donal, Bisignano, Catherine, Biswas, Raaj Kishore, Bjørge, Tone, Bohlouli, Somayeh, Bohluli, Mehdi, Bolla, Srinivasa Rao Rao, Borzì, Antonio Maria, Borzouei, Shiva, Brady, Oliver J, Braithwaite, Dejana, Brauer, Michael, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Bumgarner, Blair R, Burugina Nagaraja, Sharath, Butt, Zahid A, Caetano Dos Santos, Florentino Luciano, Cai, Tianji, Callender, Charlton Skh, Cámera, Luis La Alberto, Campos-nonato, Ismael R, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-maia, Joao Mauricio, Castelpietra, Giulio, Castro, Franz, Catalá-lópez, Ferrán, Cederroth, Christopher R, Cerin, Ester, Chattu, Vijay Kumar, Chin, Ken Lee, Chu, Dinh-toi, Ciobanu, Liliana G, Cirillo, Massimo, Comfort, Haley, Costa, Vera Marisa, Cowden, Richard G, Cromwell, Elizabeth A, Croneberger, Andrew J, Cunningham, Matthew, Dahlawi, Saad M A, Damiani, Giovanni, D'amico, Emanuele, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Darwesh, Aso Mohammad, Daryani, Ahmad, Das Gupta, Rajat, Das Neves, José, Davletov, Kairat, De Leo, Diego, Denova-gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Desai, Rupak, Dhungana, Govinda Prasad, Dias Da Silva, Diana, Diaz, Daniel, Dippenaar, Ilse N, Djalalinia, Shirin, Do, Hoa Thi, Dokova, Klara, Doku, David Teye, Dorostkar, Fariba, Doshi, Chirag P, Doshmangir, Leila, Doyle, Kerrie E, Dubljanin, Eleonora, Duraes, Andre Rodrigues, Edvardsson, David, Effiong, Andem, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, El-jaafary, Shaimaa I, Emamian, Mohammad Hassan, Eskandarieh, Sharareh, Esmaeilzadeh, Firooz, Estep, Kara, Farahmand, Mohammad, Faraj, Anwar, Fareed, Mohammad, Faridnia, Roghiyeh, Faro, Andre, Farzadfar, Farshad, Fattahi, Nazir, Fazaeli, Ali Akbar, Fazlzadeh, Mehdi, Feigin, Valery L, Fereshtehnejad, Seyed-mohammad, Fernandes, Eduarda, Ferreira, Manuela L, Filip, Irina, Fischer, Florian, Flohr, Carsten, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Freitas, Marisa, Fukumoto, Takeshi, Fuller, John E, Furtado, João M, Gad, Mohamed M, Gakidou, Emmanuela, Gallus, Silvano, Gebrehiwot, Abiyu Mekonnen, Gebremedhin, Ketema Bizuwork, Gething, Peter W, Ghamari, Farhad, Ghashghaee, Ahmad, Gholamian, Asadollah, Gilani, Syed Amir, Gitimoghaddam, Mojgan, Glushkova, Ekaterina Vladimirovna, Gnedovskaya, Elena V, Gopalani, Sameer Vali, Goulart, Alessandra C, Gugnani, Harish Chander, Guo, Yuming, Gupta, Rajeev, Gupta, Subodh Sharan, Haagsma, Juanita A, Haj-mirzaian, Arvin, Haj-mirzaian, Arya, Halvaei, Iman, Hamadeh, Randah R, Hamagharib Abdullah, Kanaan, Han, Chieh, Handiso, Demelash Woldeyohannes, Hankey, Graeme J, Haririan, Hamidreza, Li, Shanshan, Lim, Lee-ling, Nguyen, Huong Lan Thi, Nguyen, Trang Huyen, Rahman, Muhammad Aziz, Renzaho, Andre M N, Shaw, David H, Tonelli, Marcello, Wang, Yuan-pang, Murray, Christopher J L, Morawska, Lidia, other, and, Wang, Haidong, Abbas, Kaja M, Abbasifard, Mitra, Abbasi-kangevari, Mohsen, Abbastabar, Hedayat, Abd-allah, Foad, Abdelalim, Ahmed, Abolhassani, Hassan, Abreu, Lucas Guimarães, Abrigo, Michael R M, Abushouk, Abdelrahman I, Adabi, Maryam, Adair, Tim, Adebayo, Oladimeji M, Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O, Advani, Shailesh M, Afshin, Ashkan, Aghaali, Mohammad, Agrawal, Anurag, Ahmadi, Keivan, Ahmadieh, Hamid, Ahmed, Muktar Beshir, Al-aly, Ziyad, Alam, Khurshid, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M, Alcalde-rabanal, Jacqueline Elizabeth, Ali, Muhammad, Alicandro, Gianfranco, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Allebeck, Peter, Almadi, Majid Abdulrahman Hamad, Almasi-hashiani, Amir, Al-mekhlafi, Hesham M, Altirkawi, Khalid A, Alumran, Arwa Khalid, Alvis-guzman, Nelson, Amini-rarani, Mostafa, Aminorroaya, Arya, Amit, Arianna Maever L, Ancuceanu, Robert, Andrei, Catalina Liliana, Androudi, Sofia, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari, Iman, Ansari-moghaddam, Alireza, Antonio, Carl Abelardo T, Antony, Catherine M, Anvari, Davood, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-zozani, Morteza, Aravkin, Aleksandr Y, Aremu, Olatunde, Ärnlöv, Johan, Aryal, Krishna K, Asadi-pooya, Ali A, Asgari, Samaneh, Asghari Jafarabadi, Mohammad, Atteraya, Madhu Sudhan, Ausloos, Marcel, Avila-burgos, Leticia, Avokpaho, Euripide Frinel Gbenato Arthur, Ayala Quintanilla, Beatriz Paulina, Ayano, Getinet, Ayanore, Martin Amogre, Azarian, Ghasem, Babaee, Ebrahim, Badiye, Ashish D, Bagli, Eleni, Bahrami, Mohammad Amin, Bakhtiari, Ahad, Balassyano, Shelly, Banach, Maciej, Banik, Palash Chandra, Barker-collo, Suzanne Lyn, Bärnighausen, Till Winfried, Barzegar, Akbar, Basu, Sanjay, Baune, Bernhard T, Bayati, Mohsen, Bazmandegan, Gholamreza, Bedi, Neeraj, Bell, Michellr L, Bennett, Derrick A, Bensenor, Isabela M, Berhe, Kidanemaryam, Berman, Adam E, Bertolacci, Gregory J, Bhageerathy, Reshmi, Bhala, Neeraj, Bhattacharyya, Krittika, Bhutta, Zulfiqar A, Bijani, Ali, Biondi, Antonio, Bisanzio, Donal, Bisignano, Catherine, Biswas, Raaj Kishore, Bjørge, Tone, Bohlouli, Somayeh, Bohluli, Mehdi, Bolla, Srinivasa Rao Rao, Borzì, Antonio Maria, Borzouei, Shiva, Brady, Oliver J, Braithwaite, Dejana, Brauer, Michael, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Bumgarner, Blair R, Burugina Nagaraja, Sharath, Butt, Zahid A, Caetano Dos Santos, Florentino Luciano, Cai, Tianji, Callender, Charlton Skh, Cámera, Luis La Alberto, Campos-nonato, Ismael R, Cárdenas, Rosario, Carreras, Giulia, Carrero, Juan J, Carvalho, Felix, Castaldelli-maia, Joao Mauricio, Castelpietra, Giulio, Castro, Franz, Catalá-lópez, Ferrán, Cederroth, Christopher R, Cerin, Ester, Chattu, Vijay Kumar, Chin, Ken Lee, Chu, Dinh-toi, Ciobanu, Liliana G, Cirillo, Massimo, Comfort, Haley, Costa, Vera Marisa, Cowden, Richard G, Cromwell, Elizabeth A, Croneberger, Andrew J, Cunningham, Matthew, Dahlawi, Saad M A, Damiani, Giovanni, D'amico, Emanuele, Dandona, Lalit, Dandona, Rakhi, Dargan, Paul I, Darwesh, Aso Mohammad, Daryani, Ahmad, Das Gupta, Rajat, Das Neves, José, Davletov, Kairat, De Leo, Diego, Denova-gutiérrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Desai, Rupak, Dhungana, Govinda Prasad, Dias Da Silva, Diana, Diaz, Daniel, Dippenaar, Ilse N, Djalalinia, Shirin, Do, Hoa Thi, Dokova, Klara, Doku, David Teye, Dorostkar, Fariba, Doshi, Chirag P, Doshmangir, Leila, Doyle, Kerrie E, Dubljanin, Eleonora, Duraes, Andre Rodrigues, Edvardsson, David, Effiong, Andem, El Sayed, Iman, El Tantawi, Maha, Elbarazi, Iffat, El-jaafary, Shaimaa I, Emamian, Mohammad Hassan, Eskandarieh, Sharareh, Esmaeilzadeh, Firooz, Estep, Kara, Farahmand, Mohammad, Faraj, Anwar, Fareed, Mohammad, Faridnia, Roghiyeh, Faro, Andre, Farzadfar, Farshad, Fattahi, Nazir, Fazaeli, Ali Akbar, Fazlzadeh, Mehdi, Feigin, Valery L, Fereshtehnejad, Seyed-mohammad, Fernandes, Eduarda, Ferreira, Manuela L, Filip, Irina, Fischer, Florian, Flohr, Carsten, Foigt, Nataliya A, Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Freitas, Marisa, Fukumoto, Takeshi, Fuller, John E, Furtado, João M, Gad, Mohamed M, Gakidou, Emmanuela, Gallus, Silvano, Gebrehiwot, Abiyu Mekonnen, Gebremedhin, Ketema Bizuwork, Gething, Peter W, Ghamari, Farhad, Ghashghaee, Ahmad, Gholamian, Asadollah, Gilani, Syed Amir, Gitimoghaddam, Mojgan, Glushkova, Ekaterina Vladimirovna, Gnedovskaya, Elena V, Gopalani, Sameer Vali, Goulart, Alessandra C, Gugnani, Harish Chander, Guo, Yuming, Gupta, Rajeev, Gupta, Subodh Sharan, Haagsma, Juanita A, Haj-mirzaian, Arvin, Haj-mirzaian, Arya, Halvaei, Iman, Hamadeh, Randah R, Hamagharib Abdullah, Kanaan, Han, Chieh, Handiso, Demelash Woldeyohannes, Hankey, Graeme J, Haririan, Hamidreza, Li, Shanshan, Lim, Lee-ling, Nguyen, Huong Lan Thi, Nguyen, Trang Huyen, Rahman, Muhammad Aziz, Renzaho, Andre M N, Shaw, David H, Tonelli, Marcello, Wang, Yuan-pang, Murray, Christopher J L, Morawska, Lidia, and other, and

Abstract

Background Accurate and up-to-date assessment of demographic metrics is crucial for understanding a wide range of social, economic, and public health issues that affect populations worldwide. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 produced updated and comprehensive demographic assessments of the key indicators of fertility, mortality, migration, and population for 204 countries and territories and selected subnational locations from 1950 to 2019. Methods 8078 country-years of vital registration and sample registration data, 938 surveys, 349 censuses, and 238 other sources were identified and used to estimate age-specific fertility. Spatiotemporal Gaussian process regression (ST-GPR) was used to generate age-specific fertility rates for 5-year age groups between ages 15 and 49 years. With extensions to age groups 10–14 and 50–54 years, the total fertility rate (TFR) was then aggregated using the estimated age-specific fertility between ages 10 and 54 years. 7417 sources were used for under-5 mortality estimation and 7355 for adult mortality. ST-GPR was used to synthesise data sources after correction for known biases. Adult mortality was measured as the probability of death between ages 15 and 60 years based on vital registration, sample registration, and sibling histories, and was also estimated using ST-GPR. HIV-free life tables were then estimated using estimates of under-5 and adult mortality rates using a relational model life table system created for GBD, which closely tracks observed age-specific mortality rates from complete vital registration when available. Independent estimates of HIV-specific mortality generated by an epidemiological analysis of HIV prevalence surveys and antenatal clinic serosurveillance and other sources were incorporated into the estimates in countries with large epidemics. Annual and single-year age estimates of net migration and population for each country and territory were genera

Published
2020

134. Global burden of 369 diseases and injuries in 204 countries and territories, 1990-2019 : a systematic analysis for the Global Burden of Disease Study 2019

Author

Abbafati, Cristiana, Abbas, Kaja M., Abbasi, Mohammad, Abbasifard, Mitra, Abbasi-Kangevari, Mohsen, Abbastabar, Hedayat, Abd-Allah, Foad, Abdelalim, Ahmed, Abdollahi, Mohammad, Abdollahpour, Ibrahim, Abedi, Aidin, Abedi, Parisa, Abegaz, Kedir Hussein, Abolhassani, Hassan, Abosetugn, Akine Eshete, Aboyans, Victor, Abrams, Elissa M., Abreu, Lucas Guimaraes, Abrigo, Michael R. M., Abu Haimed, Abdulaziz Khalid, Abualhasan, Ahmed, Abu-Gharbieh, Eman, Abu-Raddad, Laith Jamal, Abushouk, Abdelrahman I., Acebedo, Alyssa, Ackerman, Ilana N., Adabi, Maryam, Adair, Tim, Adamu, Abdu A., Adebayo, Oladimeji M., Adedeji, Isaac Akinkunmi, Adekanmbi, Victor, Adelson, Jaimie D., Adeoye, Abiodun Moshood, Adetokunboh, Olatunji O., Adham, Davoud, Advani, Shailesh M., Afarideh, Mohsen, Afshari, Mahdi, Afshin, Ashkan, Agardh, Emilie E., Agarwal, Gina, Agasthi, Pradyumna, Agesa, Kareha M., Aghaali, Mohammad, Aghamir, Seyed Mohammad Kazem, Agrawal, Anurag, Ahmad, Tauseef, Ahmadi, Alireza, Ahmadi, Keivan, Ahmadi, Mehdi, Ahmadieh, Hamid, Ahmadpour, Ehsan, Ahmed, Muktar Beshir, Aji, Budi, Akalu, Temesgen Yihunie, Akinyemi, Rufus Olusola, Akinyemiju, Tomi, Akombi, Blessing, Akunna, Chisom Joyqueenet, Alahdab, Fares, Al-Aly, Ziyad, Alam, Khurshid, Alam, Noore, Alam, Samiah, Alam, Tahiya, Alanezi, Fahad Mashhour, Alanzi, Turki M., Albertson, Samuel B., Alcalde-Rabanal, Jacqueline Elizabeth, Alema, Niguse Meles, Alemu, Biresaw Wassihun, Alemu, Yihun Mulugeta, Alhabib, Khalid F., Alhassan, Robert Kaba, Ali, Muhammad, Ali, Saqib, Alicandro, Gianfranco, Alijanzadeh, Mehran, Alinia, Cyrus, Alipour, Vahid, Alizade, Hesam, Aljunid, Syed Mohamed, Alla, Francois, Allebeck, Peter, Almadi, Majid Abdulrahman Hamad, Almasi, Ali, Almasi-Hashiani, Amir, Almasri, Nihad A., Al-Mekhlafi, Hesham M., Almulhim, Abdulaziz M., Alonso, Jordi, Al-Raddadi, Rajaa M., Altirkawi, Khalid A., Alumran, Arwa Khalid, Alvis-Guzman, Nelson, Alvis-Zakzuk, Nelson J., Amare, Azmeraw T., Amare, Bekalu, Amini, Saeed, Amini-Rarani, Mostafa, Aminorroaya, Arya, Amiri, Fatemeh, Amit, Arianna Maever L., Amugsi, Dickson A., Amul, Gianna Gayle Herrera, Anbesu, Etsay Woldu, Ancuceanu, Robert, Anderlini, Deanna, Anderson, Jason A., Andrei, Catalina Liliana, Andrei, Tudorel, Androudi, Sofia, Angus, Colin, Anjomshoa, Mina, Ansari, Fereshteh, Ansari, Iman, Ansari-Moghaddam, Alireza, Antonazzo, Ippazio Cosimo, Antonio, Carl Abelardo T., Antony, Catherine M., Antriyandarti, Ernoiz, Anvari, Davood, Anwer, Razique, Appiah, Seth Christopher Yaw, Arabloo, Jalal, Arab-Zozani, Morteza, Aravkin, Aleksandr Y., Arba, Aseb Arba Kinfe, Aremu, Olatunde, Ariani, Filippo, Aripov, Timur, Armoon, Bahram, Arnlov, Johan, Arowosegbe, Oluwaseyi Olalekan, Aryal, Krishna K., Arzani, Afsaneh, Asaad, Malke, Asadi-Aliabadi, Mehran, Asadi-Pooya, Ali A., Asgari, Samaneh, Asghari, Babak, Jafarabadi, Mohammad Asghari, Ashbaugh, Charlie, Assmus, Michael, Atafar, Zahra, Athari, Seyyed Shamsadin, Atnafu, Desta Debalkie, Atout, Maha Moh'd Wahbi, Atre, Sachin R., Atteraya, Madhu Sudhan, Ausloos, Floriane, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide Frinel Gbenato Arthur, Quintanilla, Beatriz Paulina Ayala, Ayano, Getinet, Ayanore, Martin Amogre, Aynalem, Getie Lake, Aynalem, Yared Asmare, Ayza, Muluken Altaye, Azari, Samad, Azarian, Ghasem, Azene, Zelalem Nigussie, Azhar, Gulrez, Azzopardi, Peter S., Darshan, B. B., Babaee, Ebrahim, Badawi, Alaa, Badiye, Ashish D., Bagherzadeh, Mojtaba, Bagli, Eleni, Bahrami, Mohammad Amin, Baig, Atif Amin, Bairwa, Mohan, Bakhshaei, Mohammad Hossein, Bakhtiari, Ahad, Bakkannavar, Shankar M., Balachandran, Arun, Balakrishnan, Senthilkumar, Balalla, Shivanthi, Balassyano, Shelly, Baldasseroni, Alberto, Ball, Kylie, Ballew, Shoshana H., Balzi, Daniela, Banach, Maciej, Banerjee, Srikanta K., Banik, Palash Chandra, Bannick, Marlena S., Bante, Agegnehu Bante, Bante, Simachew Animen, Baraki, Adhanom Gebreegziabher, Barboza, Miguel A., Barker-Collo, Suzanne Lyn, Barnighausen, Till Winfried, Barrero, Lope H., Barthelemy, Celine M., Barua, Lingkan, Barzegar, Akbar, Basaleem, Huda, Bassat, Quique, Basu, Sanjay, Baune, Bernhard T., Bayati, Mohsen, Baye, Bayisa Abdissa, Bazmandegan, Gholamreza, Becker, Jacob S., Bedi, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Bejot, Yannick, Bekuma, Tariku Tesfaye Tesfaye, Bell, Michelle L., Bello, Aminu K., Bender, Rose G., Bennett, Derrick A., Bennitt, Fiona B., Bensenor, Isabela M., Benziger, Catherine P., Berhe, Kidanemaryam, Berman, Adam E., Bernabe, Eduardo, Bernstein, Robert S., Bertolacci, Gregory J., Bhagavathula, Akshaya Srikanth, Bhageerathy, Reshmi, Bhala, Neeraj, Bhandari, Dinesh, Bhardwaj, Pankaj, Bhat, Anusha Ganapati, Bhattacharyya, Krittika, Bhattarai, Suraj, Bhutta, Zulfiqar A., Bibi, Sadia, Biehl, Molly H., Bijani, Ali, Bikbov, Boris, Bilano, Ver, Bin Sayeed, Muhammad Shahdaat, Biondi, Antonio, Birihane, Binyam Minuye, Bisanzio, Donal, Bisignano, Catherine, Biswas, Raaj Kishore, Bitew, Helen, Bjorge, Tone, Bockarie, Moses John, Bohlouli, Somayeh, Bohluli, Mehdi, Bojia, Hunduma Amensisa, Bolla, Srinivasa Rao, Boloor, Archith, Boon-Dooley, Alexandra S., Borges, Guilherme, Borzi, Antonio Maria, Borzouei, Shiva, Bose, Dipan, Bosetti, Cristina, Boufous, Soufiane, Bourne, Rupert, Brady, Oliver J., Braithwaite, Dejana, Brauer, Michael, Brayne, Carol, Breitborde, Nicholas J. K., Breitner, Susanne, Brenner, Hermann, Breusov, Alexey V., Briant, Paul Svitil, Briggs, Andrew M., Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Britton, Gabrielle B., Brugha, Traolach, Bryazka, Dana, Buchbinder, Rachelle, Bumgarner, Blair R., Burkart, Katrin, Burnett, Richard Thomas, Nagaraja, Sharath Burugina, Busse, Reinhard, Butt, Zahid A., Caetano dos Santos, Florentino Luciano, Cahill, Leah E., Cahuana-Hurtado, Lucero, Cai, Tianji, Callender, Charlton S. K. H., Camera, Luis Alberto, Campos-Nonato, Ismael R., Rincon, Julio Cesar Campuzano, Cao, Jackie, Car, Josip, Cardenas, Rosario, Carreras, Giulia, Carrero, Juan J., Carvalho, Felix, Castaldelli-Maia, Joao Mauricio, Castaneda-Orjuela, Carlos A., Castelpietra, Giulio, Castle, Chris D., Castro, Emma, Castro, Franz, Catala-Lopez, Ferran, Causey, Kate, Cederroth, Christopher R., Cercy, Kelly M., Cerin, Ester, Chalek, Julian, Chandan, Joht Singh, Chang, Alex R., Chang, Angela Y., Chang, Jung-Chen, Chang, Kai-Lan, Charan, Jaykaran, Charlson, Fiona J., Chattu, Vijay Kumar, Chaturvedi, Sarika, Cherbuin, Nicolas, Chimed-Ochir, Odgerel, Chin, Ken Lee, Chirinos-Caceres, Jesus Lorenzo, Cho, Daniel Youngwhan, Choi, Jee-Young Jasmine, Christensen, Hanne, Chu, Dinh-Toi, Chung, Michael T., Chung, Sheng-Chia, Cicuttini, Flavia M., Ciobanu, Liliana G., Cirillo, Massimo, Cislaghi, Beniamino, Classen, Thomas Khaled Dwayne, Cohen, Aaron J., Collins, Emma L., Comfort, Haley, Compton, Kelly, Conti, Sara, Cooper, Owen R., Corso, Barbara, Cortesi, Paolo Angelo, Costa, Vera Marisa, Cousin, Ewerton, Cowden, Richard G., Cowie, Benjamin C., Cromwell, Elizabeth A., Croneberger, Andrew J., Cross, Di H., Cross, Marita, Crowe, Christopher Stephen, Cruz, Jessica A., Cummins, Steven, Cunningham, Matthew, Dahlawi, Saad M. A., Dai, Haijiang, Dai, Hancheng, Damasceno, Albertino Antonio Moura, Damiani, Giovanni, D'Amico, Emanuele, Dandona, Lalit, Dandona, Rakhi, Daneshpajouhnejad, Parnaz, Dangel, William James, Danielsson, Anna-Karin, Gela, Jiregna Darega, Dargan, Paul I., Darwesh, Aso Mohammad, Daryani, Ahmad, Das, Jai K., Das Gupta, Rajat, Das Neves, Jose, Dash, Aditya Prasad, Davey, Gail, Davila-Cervantes, Claudio Alberto, Davis, Adrian C., Davitoiu, Dragos Virgil, Davletov, Kairat, De Leo, Diego, De Neve, Jan-Walter, Dean, Frances E., DeCleene, Nicole K., Deen, Amanda, Degenhardt, Louisa, DeLang, Marissa, Dellavalle, Robert Paul, Demeke, Feleke Mekonnen, Demoz, Gebre Teklemariam, Demsie, Desalegn Getnet, Denova-Gutierrez, Edgar, Dereje, Nebiyu Dereje, Deribe, Kebede, Dervenis, Nikolaos, Desai, Rupak, Desalew, Assefa, Dessie, Getenet Ayalew, Deuba, Keshab, Dharmaratne, Samath Dhamminda, Dhungana, Govinda Prasad, Dianatinasab, Mostafa, da Silva, Diana Dias, Diaz, Daniel, Forooshani, Zahra Sadat Dibaji, Dichgans, Martin, Didarloo, Alireza, Dingels, Zachary V., Dippenaar, Ilse N., Dirac, M. Ashworth, Djalalinia, Shirin, Do, Hoa Thi, Dokova, Klara, Doku, David Teye, Dolecek, Christiane, Dolgert, Andrew J., Dorostkar, Fariba, Doshi, Chirag P., Doshi, Pratik P., Doshmangir, Leila, Douiri, Abdel, Doxey, Matthew C., Doyle, Kerrie E., Driscoll, Tim Robert, Dubljanin, Eleonora, Dunachie, Susanna J., Duncan, Bruce B., Duraes, Andre Rodrigues, Eagan, Arielle Wilder, Ebrahimi, Hedyeh, Kalan, Mohammad Ebrahimi, Edvardsson, David, Effiong, Andem, Ehrlich, Joshua R., El Nahas, Nevine, El Sayed, Iman, Zaki, Maysaa El Sayed, El Tantawi, Maha, Elbarazi, Iffat, Elgendy, Islam Y., Elhabashy, Hala Rashad, El-Jaafary, Shaimaa I., Elsharkawy, Aisha, Elyazar, Iqbal R. F., Emamian, Mohammad Hassan, Emmons-Bell, Sophia, Erskine, Holly E., Eshrati, Babak, Eskandari, Khalil, Eskandarieh, Sharareh, Esmaeilnejad, Saman, Esmaeilzadeh, Firooz, Esteghamati, Alireza, Esteghamati, Sadaf, Estep, Kara, Etemadi, Arash, Etisso, Atkilt Esaiyas, Ezekannagha, Oluchi, Fanzo, Jessica, Farag, Tamer, Farahmand, Mohammad, Faraj, Anwar, Faraon, Emerito Jose A., Fareed, Mohammad, Faridnia, Roghiyeh, Farinha, Carla Sofia e Sa, Farioli, Andrea, Faris, Pawan Sirwan, Faro, Andre, Faruque, Mithila, Farzadfar, Farshad, Fattahi, Nazir, Fazaeli, Ali Akbar, Fazlzadeh, Mehdi, Feigin, Valery L., Feldman, Rachel, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Ferrara, Giannina, Ferrara, Pietro, Ferrari, Alize J., Ferreira, Manuela L., Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Fisher, James L., Fitzgerald, Ryan, Flohr, Carsten, Flor, Luisa Sorio, Foigt, Nataliya A., Folayan, Morenike Oluwatoyin, Fomenkov, Artem Alekseevich, Force, Lisa M., Fornari, Carla, Foroutan, Masoud, Fox, Jack T., Francis, Joel Msafiri, Frank, Tahvi D., Franklin, Richard Charles, Freitas, Marisa, Fu, Weijia, Fukumoto, Takeshi, Fukutaki, Kai, Fuller, John E., Fullman, Nancy, Furtado, Joao M., Gad, Mohamed M., Gaidhane, Abhay Motiramji, Gakidou, Emmanuela, Galles, Natalie C., Gallus, Silvano, Gamkrelidze, Amiran, Garcia-Basteiro, Alberto L., Gardner, William M., Geberemariyam, Biniyam Sahiledengle, Gebrehiwot, Abiyu Mekonnen, Gebremedhin, Ketema Bizuwork, Gebremeskel, Gebreamlak Gebremedhn, Gebremeskel, Leake G., Gebresillassie, Begashaw Melaku, Gebreslassie, Assefa Ayalew Ayalew Ayalew, Geramo, Yilma Chisha Dea, Geremew, Abraham, Hayoon, Anna Gershberg, Gesesew, Hailay Abrha, Gething, Peter W., Gezae, Kebede Embaye, Ghadimi, Maryam, Ghadiri, Keyghobad, Ghaffarifar, Fatemeh, Ghafourifard, Mansour, Ghajar, Alireza, Ghamari, Farhad, Ghashghaee, Ahmad, Ghiasvand, Hesam, Ghith, Nermin, Gholamian, Asadollah, Ghosh, Rakesh, Giampaoli, Simona, Gilani, Syed Amir, Gill, Paramjit Singh, Gill, Tiffany K., Gillum, Richard F., Ginawi, Ibrahim Abdelmageed, Ginindza, Themba G., Gitimoghaddam, Mojgan, Giussani, Giorgia, Glagn, Mustefa, Glushkova, Ekaterina Vladimirovna, Gnedovskaya, Elena V., Godinho, Myron Anthony, Goharinezhad, Salime, Golechha, Mahaveer, Goli, Srinivas, Gomez, Ricardo Santiago, Gona, Philimon N., Gopalani, Sameer Vali, Goren, Emily, Gorini, Giuseppe, Gorman, Taren M., Gottlich, Harrison Chase, Goudarzi, Houman, Goudarzian, Amir Hossein, Goulart, Alessandra C., Goulart, Barbara Niegia Garcia, Grada, Ayman, Greaves, Felix, Grivna, Michal, Grosso, Giuseppe, Gubari, Mohammed Ibrahim Mohialdeen, Gudi, Nachiket, Gugnani, Harish Chander, Guimaraes, Andre Luiz Sena, Guimaraes, Rafael Alves, Guled, Rashid Abdi, Gultie, Teklemariam, Guo, Gaorui, Guo, Yuming, Gupta, Rahul, Gupta, Rajeev, Sharan, Subodh, Gupta, Tarun, Haagsma, Juanita A., Hachinski, Vladimir, Haddock, Beatrix, Hafezi-Nejad, Nima, Hafiz, Abdul, Hagins, Hailey, Haile, Lydia M., Haile, Teklehaimanot Gereziher, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hall, Brian J., Halvaei, Iman, Hamadeh, Randah R., Abdullah, Kanaan Hamagharib, Hameed, Sajid, Hamidi, Samer, Hamilton, Erin B., Hammer, Melanie S., Han, Chieh, Han, Hannah, Handiso, Demelash Woldeyohannes, Hanif, Asif, Hankey, Graeme J., Haririan, Hamidreza, Haro, Josep Maria, Harvey, James D., Hasaballah, Ahmed I., Hasan, Md Mehedi, Hasanpoor, Edris, Hasanzadeh, Amir, Hashemian, Maryam, Hashi, Abdiwahab, Hassan, Amr, Hassan, Shoaib, Hassanipour, Soheil, Hassankhani, Hadi, Havmoeller, Rasmus J., Hay, Roderick J., Hay, Simon I., Hayat, Khezar, Heibati, Behzad, Heidari, Behnam, Heidari, Golnaz, Heidari-Soureshjani, Reza, Hendrie, Delia, Henny, Kiana, Henok, Andualem, Henrikson, Hannah J., Henry, Nathaniel J., Herbert, Molly E., Herteliu, Claudiu, Heydarpour, Fatemeh, Hird, Thomas R., Ho, Hung Chak, Hoek, Hans W., Hole, Michael K., Holla, Ramesh, Hollingsworth, Bruce, Hoogar, Praveen, Hopf, Kathleen Pillsbury, Horita, Nobuyuki, Hosgood, H. Dean, Hossain, Naznin, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hoy, Damian G., Hsairi, Mohamed, Hsiao, Thomas, Hsieh, Vivian Chia-Rong, Hu, Guoqing, Hu, Kejia, Huda, Tanvir M., Hugo, Fernando N., Humayun, Ayesha, Hussain, Rabia, Huynh, Chantal K., Hwang, Bing-Fang, Iannucci, Vincent C., Iavicoli, Ivo, Ibeneme, Charles Ugochukwu, Ibitoye, Segun Emmanuel, Ikeda, Nayu, Ikuta, Kevin S., Ilesanmi, Olayinka Stephen, Ilic, Irena M., Ilic, Milena D., Imani-Nasab, Mohammad Hasan, Inbaraj, Leeberk Raja, Ippolito, Helen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, M. Mofizul, Islam, MdMohaimenul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Iso, Hiroyasu, Ivers, Rebecca Q., Iwu, Chidozie C. D., Iwu, Chinwe Juliana, Iyamu, Ihoghosa Osamuyi, Jaafari, Jalil, Jacobsen, Kathryn H., Jadidi-Niaragh, Farhad, Jafari, Hussain, Jafarinia, Morteza, Jahagirdar, Deepa, Jahani, Mohammad Ali, Jahanmehr, Nader, Jakovljevic, Mihajlo, Jalali, Amir, Jalilian, Farzad, James, Spencer L., Janjani, Hosna, Janodia, Manthan Dilipkumar, Javaheri, Tahereh, Javidnia, Javad, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jha, Vivekanand, Ji, John S., Jia, Peng, Johansson, Lars, John, Oommen, John-Akinola, Yetunde O., Johnson, Catherine Owens, Johnson, Sarah Charlotte, Jonas, Jost B., Joo, Tamas, Joshi, Ankur, Joukar, Farahnaz, Jozwiak, Jacek Jerzy, Jurisson, Mikk, Kabir, Ali, Kabir, Zubair, Kalani, Hamed, Kalani, Rizwan, Kalankesh, Leila R., Kalhor, Rohollah, Kamath, Aruna M., Kamiab, Zahra, Kanchan, Tanuj, Kapoor, Neeti, Matin, Behzad Karami, Karanikolos, Marina, Karch, Andre, Karim, Mohd Anisul, Karimi, Salah Eddin, Karimi, Seyed Asaad, Karimi, Seyed M., Kasa, Ayele Semachew, Kassa, Getachew Mullu, Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kawakami, Norito, Kayode, Gbenga A., Karyani, Ali Kazemi, Keddie, Suzanne H., Keiyoro, Peter Njenga, Keller, Cathleen, Kemmer, Laura, Kendrick, Parkes J., Kereselidze, Maia, Khader, Yousef Saleh, Khafaie, Morteza Abdullatif, Khalid, Nauman, Khammarnia, Mohammad, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khan, Maseer, Khang, Young-Ho, Khatab, Khaled, Khater, Amir M., Khater, Mona M., Khatib, Mahalaqua Nazli, Khayamzadeh, Maryam, Khazaei, Salman, Khazaie, Habibolah, Khodayari, Mohammad Taghi, Khoja, Abdullah T., Khubchandani, Jagdish, Khundkar, Roba, Kianipour, Neda, Kieling, Christian, Kim, Cho-Il, Kim, Daniel, Kim, Young-Eun, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kisa, Adnan, Kisa, Sezer, Kissimova-Skarbek, Katarzyna, Kissoon, Niranjan, Kivimaki, Mika, Kneib, Cameron J., Knibbs, Luke D., Knight, Megan, Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M., Kochhar, Sonali, Koh, David S. Q., Kohler, Stefan, Kolola, Tufa, Komaki, Hamidreza, Kopec, Jacek A., Korotkova, Anna V., Korshunov, Vladimir Andreevich, Kosen, Soewarta, Kotlo, Anirudh, Koul, Parvaiz A., Koyanagi, Ai, Kraemer, Moritz U. G., Kravchenko, Michael A., Krishan, Kewal, Krohn, Kris J., Kromhout, Hans, Shaji, K. S., Defo, Barthelemy Kuate, Bicer, Burcu Kucuk, Kugbey, Nuworza, Kulkarni, Vaman, Kumar, G. Anil, Kumar, Manasi, Kumar, Nithin, Kumar, Pushpendra, Kumar, Vivek, Kumaresh, Girikumar, Kurmi, Om P., Kusuma, Dian, Kyu, Hmwe Hmwe, La Vecchia, Carlo, Lacey, Ben, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lam, Jennifer O., Lami, Faris Hasan, Lan, Qing, Landires, Ivan, Lang, Justin J., Langan, Sinead M., Lansingh, Van Charles, Lansky, Sonia, Larson, Heidi Jane, Larson, Samantha Leigh, Larsson, Anders, Lasrado, Savita, Lassi, Zohra S., Lau, Kathryn Mei-Ming, Lauriola, Paolo, Lavados, Pablo M., Lazarus, Jeffrey V., Leal, Lisiane F., Leasher, Janet L., Ledesma, Jorge R., Lee, Paul H., Lee, Shaun Wen Huey, Leever, Andrew T., LeGrand, Kate E., Leigh, James, Leonardi, Matilde, Lescinsky, Haley, Leung, Janni, Levi, Miriam, Lewington, Sarah, Li, Bingyu, Li, Shanshan, Lim, Lee-Ling, Lin, Christine, Lin, Ro-Ting, Linehan, Christine, Linn, Shai, Listl, Stefan, Liu, Hung-Chun, Liu, Shiwei, Liu, Simin, Liu, Xuefeng, Liu, Yang, Liu, Zichen, Lo, Justin, Lodha, Rakesh, Logroscino, Giancarlo, Looker, Katharine J., Lopez, Alan D., Lopez, Jaifred Christian F., Lopukhov, Platon D., Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lu, Alton, Lucas, Tim C. D., Lugo, Alessandra, Lunevicius, Raimundas, Lyons, Ronan A., Ma, Jianing, Machado, Daiane Borges, MacLachlan, Jennifer H., Madadin, Mohammed, Maddison, Emilie R., Maddison, Ralph, Madotto, Fabiana, Abd El Razek, Hassan Magdy, Abd El Razek, Muhammed Magdy, Mahasha, Phetole Walter, Mahdavi, Mokhtar Mahdavi, Mahmoudi, Morteza, Mai, Hue Thi, Majeed, Azeem, Malagon-Rojas, Jeadran N., Maled, Venkatesh, Maleki, Afshin, Maleki, Shokofeh, Malekzadeh, Reza, Malta, Deborah Carvalho, Mamun, Abdullah A., Manafi, Amir, Manafi, Navid, Manda, Ana Laura, Manguerra, Helena, Mansour-Ghanaei, Fariborz, Mansouri, Borhan, Mansournia, Mohammad Ali, Herrera, Ana M. Mantilla, Mapoma, Chabila Christopher, Maravilla, Joemer C., Marks, Ashley, Martin, Randall V., Martini, Santi, Martins-Melo, Francisco Rogerlandio, Martopullo, Ira, Masaka, Anthony, Masoumi, Seyedeh Zahra, Massano, Joao, Massenburg, Benjamin Ballard, Mastrogiacomo, Claudia I., Mathur, Manu Raj, Matsushita, Kunihiro, Maulik, Pallab K., May, Erin A., Mazidi, Mohsen, McAlinden, Colm, McGrath, John J., Mckee, Martin, Medina-Solis, Carlo Eduardo, Meharie, Birhanu Geta, Mehndiratta, Man Mohan, Nasab, Entezar Mehrabi, Mehri, Fereshteh, Mehrotra, Ravi, Mehta, Kala M., Meitei, Wahengbam Bigyananda, Mekonnen, Teferi, Melese, Addisu, Memiah, Peter T. N., Memish, Ziad A., Mendoza, Walter, Menezes, Ritesh G., Mengesha, Endalkachew Worku, Mengesha, Meresa Berwo, Mensah, George A., Mereke, Alibek, Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J., Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Michalek, Irmina Maria, Mihretie, Kebadnew Mulatu, Miller, Ted R., Mills, Edward J., Milne, George J., Mini, G. K., Miri, Mohammad, Mirica, Andreea, Mirrakhimov, Erkin M., Mirzaei, Hamed, Mirzaei, Maryam, Mirzaei, Roya, Mirzaei-Alavijeh, Mehdi, Misganaw, Awoke Temesgen, Mitchell, Philip B., Mithra, Prasanna, Moazen, Babak, Moghadaszadeh, Masoud, Mohajer, Bahram, Mohamad, Osama, Mohamadi, Efat, Mohammad, Dara K., Mohammad, Yousef, Mezerji, Naser Mohammad Gholi, Mohammadbeigi, Abolfazl, Mohammadian-Hafshejani, Abdollah, Mohammadifard, Noushin, Mohammadpourhodki, Reza, Mohammed, Ammas Siraj, Mohammed, Hussen, Mohammed, Jemal Abdu, Mohammed, Shafiu, Mohebi, Farnam, Bandpei, Mohammad A. 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H., Pasovic, Maja, Pasupula, Deepak Kumar, Patel, Jenil R., Patel, Sangram Kishor, Paternina-Caicedo, Angel J., Pathak, Ashish, Pathak, Mona, Patten, Scott B., Patton, George C., Paudel, Deepak, Paudel, Sagun, Paulson, Katherine R., Toroudi, Hamidreza Pazoki, Pease, Spencer A., Peden, Amy E., Pennini, Alyssa, Pepito, Veincent Christian Filipino, Peprah, Emmanuel K., Pereira, Alexandre, Pereira, David M., Pereira, Jeevan, Perico, Norberto, Pescarini, Julia Moreira, Pesudovs, Konrad, Pham, Hai Quang, Phillips, Michael R., Piccinelli, Cristiano, Pierce, Maxwell, Pigott, David M., Pilgrim, Thomas, Pilz, Tessa M., Pinheiro, Marina, Piradov, Michael A., Pirsaheb, Meghdad, Pishgar, Farhad, Plana-Ripoll, Oleguer, Plass, Dietrich, Pletcher, Martin, Pokhrel, Khem Narayan, Polibin, Roman V., Polinder, Suzanne, Polkinghorne, Kevan R., Pond, Constance Dimity, Postma, Maarten J., Pottoo, Faheem Hyder, Pourjafar, Hadi, Pourmalek, Farshad, Kalhori, Reza Pourmirza, Pourshams, Akram, Poznanska, Anna, Prada, Sergio I., Prakash, Sanjay, Prakash, V., Prasad, Narayan, Preotescu, Liliana, Pribadi, Dimas Ria Angga, Pupillo, Elisabetta, Quazi Syed, Zahiruddin, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiee, Ata, Rafiei, Alireza, Raggi, Alberto, Rahim, Fakher, Rahimi-Movaghar, Afarin, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rajabpour-Sanati, Ali, Rajati, Fatemeh, Rakovac, Ivo, Ram, Pradhum, Ramezanzadeh, Kiana, Rana, Saleem Muhammad, Ranabhat, Chhabi Lal, Ranta, Annemarei, Rao, Puja C., Rao, Sowmya J., Rasella, Davide, Rashedi, Vahid, Rastogi, Prateek, Rath, Goura Kishor, Rathi, Priya, Rawaf, David Laith, Rawaf, Salman, Rawal, Lal, Rawassizadeh, Reza, Rawat, Ramu, Razo, Christian, Boston, Sofia, Regassa, Lemma Demissie, Reiner, Robert C., Jr., Reinig, Nickolas, Reitsma, Marissa Bettay, Remuzzi, Giuseppe, Renjith, Vishnu, Renzaho, Andre M. N., Resnikoff, Serge, Rezaei, Negar, Rezaei, Nima, Rezai, Mohammad Sadegh, Rezapour, Aziz, Rhinehart, Phoebe-Anne, Riahi, Seyed Mohammad, Ribeiro, Antonio Luiz P., Ribeiro, Daniel Cury, Ribeiro, Daniela, Rickard, Jennifer, Rivera, Juan A., Robalik, Toshana, Roberts, Nicholas L. S., Roberts, Shaun, Robinson, Stephen R., Rodriguez-Ramirez, Sonia, Roever, Leonardo, Rolfe, Sam, Romoli, Michele, Ronfani, Luca, Room, Robin, Roshandel, Gholamreza, Rostamian, Morteza, Roth, Gregory A., Rothenbacher, Dietrich, Rubagotti, Enrico, Rumisha, Susan Fred, Rwegerera, Godfrey M., Saadatagah, Seyedmohammad, Sabour, Siamak, Sachdev, Perminder S., Saddik, Basema, Sadeghi, Ehsan, Sadeghi, Masoumeh, Saeedi, Reza, Moghaddam, Sahar Saeedi, Saeidi, Shahram, Safari, Yahya, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Sajadi, S. Mohammad, Salahshoor, Mohammad Reza, Salam, Nasir, Salama, Joseph S., Salamati, Payman, Zahabi, Saleh Salehi, Salem, Hosni, Salem, Marwa R., Salimi, Yahya, Salimzadeh, Hamideh, Salman, Omar Mukhtar, Salomon, Joshua A., Salz, Inbal, Samad, Zainab, Kafil, Hossein Samadi, Sambala, Evanson Zondani, Samy, Abdallah M., Sanabria, Juan, Sanchez-Pimienta, Tania G., Santomauro, Damian Francesco, Santos, Itamar S., Santos, Joao Vasco, Santric-Milicevic, Milena M., Saraswathy, Sivan Yegnanarayana Iyer, Sarmiento-Suarez, Rodrigo, Sarrafzadegan, Nizal, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Sathish, Thirunavukkarasu, Sattin, Davide, Savic, Miloje, Sawyer, Susan M., Saxena, Deepak, Saxena, Sonia, Saylan, Mete, Sbarra, Alyssa N., Schaeffer, Lauren E., Schiavolin, Silvia, Schlaich, Markus P., Schmidt, Maria Ines, Schutte, Aletta Elisabeth, Schwebel, David C., Schwendicke, Falk, Seedat, Soraya, Sekerija, Mario, Senbeta, Anbissa Muleta, Senthilkumaran, Subramanian, Sepanlou, Sadaf G., Serdar, Berrin, Serre, Marc L., Servan-Mori, Edson, Sha, Feng, Shabani, Mahsima, Shackelford, Katya Anne, Shadid, Jamileh, Shafaat, Omid, Shahabi, Saeed, Shahbaz, Mohammad, Shaheen, Amira A., Shaikh, Masood Ali, Shalash, Ali S., Shams-Beyranvand, Mehran, Shamsi, MohammadBagher, Shamsizadeh, Morteza, Shannawaz, Mohammed, Sharafi, Kiomars, Sharafi, Zeinab, Sharara, Fablina, Sharifi, Hamid, Sharma, Rajesh, Shaw, David H., Sheena, Brittney S., Sheikh, Aziz, Sheikhtaheri, Abbas, Shetty, B. 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M., Zlavog, Bianca S., Zodpey, Sanjay, Lim, Stephen S., and Murray, Christopher J. L.

Abstract

In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the post

Published
2020
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135. Comparative untargeted metabolomics analysis of the psychostimulants 3,4-methylenedioxy-methamphetamine (MDMA), amphetamine, and the novel psychoactive substance mephedrone after controlled drug administration to humans

Author

Steuer, Andrea Eva, Kaelin, Daria, Boxler, Martina I, Eisenbeiss, Lisa, Holze, Friederike, Vizeli, Patrick, Czerwinska, Joanna, Dargan, Paul I, Abbate, Vincenzo, Liechti, Matthias E, Kraemer, Thomas, Steuer, Andrea Eva, Kaelin, Daria, Boxler, Martina I, Eisenbeiss, Lisa, Holze, Friederike, Vizeli, Patrick, Czerwinska, Joanna, Dargan, Paul I, Abbate, Vincenzo, Liechti, Matthias E, and Kraemer, Thomas

Abstract

Psychoactive stimulants are a popular drug class which are used recreationally. Over the last decade, large numbers of new psychoactive substances (NPS) have entered the drug market and these pose a worldwide problem to human health. Metabolomics approaches are useful tools for simultaneous detection of endogenous metabolites affected by drug use. They allow identification of pathways or characteristic metabolites, which might support the understanding of pharmacological actions or act as indirect biomarkers of consumption behavior or analytical detectability. Herein, we performed a comparative metabolic profiling of three psychoactive stimulant drugs 3,4-methylenedioxymethamphetamine (MDMA), amphetamine and the NPS mephedrone by liquid chromatography-high resolution mass spectrometry (LC-HRMS) in order to identify common pathways or compounds. Plasma samples were obtained from controlled administration studies to humans. Various metabolites were identified as increased or decreased based on drug intake, mainly belonging to energy metabolism, steroid biosynthesis and amino acids. Linoleic acid and pregnenolone-sulfate changed similarly in response to intake of all drugs. Overall, mephedrone produced a profile more similar to that of amphetamine than MDMA in terms of affected energy metabolism. These data can provide the basis for further in-depth targeted metabolome studies on pharmacological actions and search for biomarkers of drug use.

Published
2020

139. Ketamine

Author

Li, Qi, primary, Man Chan, Wai, additional, Rudd, John A., additional, Mei Wang, Chun, additional, Lam, Phoebe Y.H., additional, Mun Wai, Maria Sen, additional, Wood, David M., additional, Dargan, Paul I., additional, and Yew, David T., additional

Published
2013
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140. List of Contributors

Author

Archer, John R.H., primary, Arunotayanun, Warunya, additional, Auwärter, Volker, additional, Braithwaite, Robin A., additional, Brandt, Simon D., additional, Dargan, Paul I., additional, Evans-Brown, Michael J., additional, Gallegos, Ana, additional, Garlich, Fiona M., additional, Gee, Paul, additional, Gibbons, Simon, additional, Greene, Shaun L., additional, Hoffman, Robert S., additional, Kenny, Padraigin, additional, Kicman, Andrew T., additional, King, Leslie A., additional, Lam, Phoebe Y.H., additional, Lapoint, Jeff, additional, Li, Qi, additional, Man Chan, Wai, additional, McVeigh, James, additional, Measham, Fiona, additional, Mei Wang, Chun, additional, Meyer, Markus R., additional, Mounteney, Jane, additional, Mun Wai, Maria Sen, additional, Peters, Frank T., additional, Rudd, John A., additional, Schep, Leo, additional, Sedefov, Roumen, additional, Smith, Silas W., additional, Sumnall, Harry, additional, White, Michael W., additional, Wood, David M., additional, and Yew, David T., additional

Published
2013
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150. Management of paracetamol poisoning

Author

Dargan, Paul I. and Jones, Alison L.

Subjects
Acetaminophen -- Research, Poisoning -- Research, Pharmacology -- Research, Biological sciences, Chemistry, Pharmaceuticals and cosmetics industries
Abstract

Paracetamol is the most common substance involved in self-poisoning in the UK. The main advances made over the past five years in the management of early paracetamol poisoning, identification of risk factors for paracetamol poisoning, understanding of the mechanisms and management of late paracetamol poisoning and issues concerning the prevention of paracetamol poisoning are discussed.

Published
2003

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