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102. Ineficiência da Thuja occidentalis no tratamento dos poxvirus aviários Thuja occidentalis ineficiency in avian poxviruses treatment

Author

Thaís Castelo Branco Chaves, Aline Rodrigues Bernardo, Argemiro Sanavria, Marilene de Farias Brito, Geraldo Baêta da Cruz, Maria das Graças Miranda Danelli, and Carlos Mazur

Subjects
poxviroses, avipoxvirus, Thuja occidentalis, Tuia, poxvirosis, Arbor vitae, Agriculture, Agriculture (General), S1-972
Abstract

Medicações à base de Tuia (Thuja occidentalis) são comuns em tratamentos homeopáticos e fitoterápicos, na medicina humana e veterinária. Suas propriedades imunoestimulantes e antivirais são descritas e sua utilização empírica no tratamento das poxviroses aviárias é recomendada por criadores e veterinários. Para avaliar o potencial terapêutico da Tuia sobre estas infecções, dois grupos (controle e teste) de dez aves jovens foram inoculados por escarificação, com uma amostra de campo de poxvírus aviário. As aves inoculadas foram examinadas diariamente, quanto ao início e evolução das lesões, registrando-se o número e tamanho destas, até a cicatrização. Após o surgimento das lesões, o grupo teste recebeu a tintura alcoólica diluída na água de consumo. A análise experimental indicou que, nas condições empregadas, a utilização da Tuia não favoreceu a regressão ou restrição no desenvolvimento das lesões de pele promovidas pela infecção experimental.Arbor Vitae (Thuja occidentalis) is widely used in homoeopathic and phytotherapic treatments,either for human or for animals. Its immunestimulating and antiviral properties have been described and its empiric use in the treatment of the avian poxvirosis is recommended by animal breeders and veterinarians. To evaluate the therapeutic potential of Arbor Vitae in these infections, two groups (control and test) of 10 young birds were inoculated by scarification with a field sample of avian poxvirus. When lesions were first observed the test group received the Arbor Vitae alcoholic extract diluted in the drinking water. The birds were examined daily, from the beginning and evolution of the lesions to the healing. The results indicated that, in our experimental conditions, the use of T. occidentalis did not favor the regression or restriction in the development of the skin lesions promoted by the experimental infection.

Published
2006
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104. Differences in visceral fat and fat bacterial colonization between ulcerative colitis and Crohn's disease. An in vivo and in vitro study.

Author

Alessandra Zulian, Raffaella Cancello, Chiara Ruocco, Davide Gentilini, Anna Maria Di Blasio, Piergiorgio Danelli, Giancarlo Micheletto, Elisabetta Cesana, and Cecilia Invitti

Subjects
Medicine, Science
Abstract

Crohn's disease (CD) is notably characterized by the expansion of visceral fat with small adipocytes expressing a high proportion of anti-inflammatory genes. Conversely, visceral fat depots in ulcerative colitis (UC) patients have never been characterized. Our study aims were a) to compare adipocyte morphology and gene expression profile and bacterial translocation in omental (OM) and mesenteric (MES) adipose tissue of patients with UC and CD, and b) to investigate the effect of bacterial infection on adipocyte proliferation in vitro. Specimens of OM and MES were collected from 11 UC and 11 CD patients, processed and examined by light microscopy. Gene expression profiles were evaluated in adipocytes isolated from visceral adipose tissue using microarray and RTqPCR validations. Bacteria within adipose tissue were immuno-detected by confocal scanning laser microscopy. Adipocytes were incubated with Enterococcus faecalis and cells counted after 24 h. Morphology and molecular profile of OM and MES revealed that UC adipose tissue is less inflamed than CD adipose tissue. Genes linked to inflammation, bacterial response, chemotaxis and angiogenesis were down-regulated in adipocytes from UC compared to CD, whereas genes related to metallothioneins, apoptosis pathways and growth factor binding were up-regulated. A dense perinuclear positivity for Enterococcus faecalis was detected in visceral adipocytes from CD, whereas positivity was weak in UC. In vitro bacterial infection was associated with a five-fold increase in the proliferation rate of OM preadipocytes. Compared to UC, visceral adipose tissue from CD is more inflamed and more colonized by intestinal bacteria, which increase adipocyte proliferation. The influence of bacteria stored within adipocytes on the clinical course of IBD warrants further investigations.

Published
2013
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105. N-terminal amino acid sequences of the major outer membrane proteins from a Neisseria meningitidis group B strain isolated in Brazil

Author

Salvatore Giovanni De Simone, Solange AF Soares, Andre LA Souza, and Maria GM Danelli

Subjects
Neisseria meningitidis group B, outer membrane proteins, class specific proteins, N-terminal amino acid sequence, Microbiology, QR1-502, Infectious and parasitic diseases, RC109-216
Abstract

The four dominant outer membrane proteins (46, 38, 33 and 28 kDa) were detected by sodium dodecyl sulfate-polyacrylamide gel electrophoresis (SDS-PAGE) in a semi-purified preparation of vesicle membranes of a Neisseria meningitidis (N44/89, B:4:P1.15:P5.5,7) strain isolated in Brazil. The N-terminal amino acid sequence for the 46 kDa and 28 kDa proteins matched that reported by others for class 1 and 5 proteins respectively, whereas the sequence (25 amino acids) for the 38 kDa (class 3) protein was similar to class 1 meningococcal proteins. The sequence for the 33 kDa (class 4) was unique and not homologous to any known protein.

Published
1996
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107. Importância da resistência osmótica na estabilidade do antígeno celular de Mycoplasma mycoides subesp. mycoides tipo LC em ensaio imunoenzimático (ELISA)

Author

Lizeu Jackeline Oliveira Pontes and Danelli Maria das Graças Miranda

Subjects
resistência osmótica, Mycoplasma Mycoides, ELISA, Agriculture, Agriculture (General), S1-972
Abstract

O trabalho avalia a importância das condições de armazenamento do antígeno celular de Mycoplasma Mycoides subesp. Mycoides Tipo LC no teste de ELISA. Os resultados mostram a importância da preservação da integridade da célula micoplásmica na estabilidade do antígeno empregado no teste.

Published
2004

108. Antigenotoxic Effect of Piperine in Broiler Chickens Intoxicated with Aflatoxin B1

Author

Verônica da Silva Cardoso, Alane Beatriz Vermelho, Cristina Amorim Ribeiro de Lima, Jéssica Mendes de Oliveira, Marco Edilson Freire de Lima, Lúcia Helena Pinto da Silva, Glória Maria Direito, and Maria das Graças Miranda Danelli

Subjects
aflatoxin B1, broiler chicken, piperine, Aspergillus, Medicine
Abstract

Piperine is an abundant amide extracted from black pepper seeds which has been shown to have protective effects against cytotoxic and genotoxic carcinogenesis induced by certain chemical carcinogens and aflatoxin B1 (AFB1) in vitro. The aim of this work was to study, in vivo, the antigenotoxic potential of feed-added piperine on broiler chickens experimentally intoxicated with AFB1, using micronucleus and comet assays. The antigenotoxicity assessment of 9-day-old chicks was performed on a total of 60 chickens divided into four groups of 15 broilers each: (C) control, (P) 60 mg·piperine kg−1 feed, (A) 0.5 mg·AFB1·kg−1 body weight, (daily by oral route), and (P + A) co-treatment with piperine and AFB1. The experiment was conducted for 26 days. Chicks intoxicated with AFB1 showed significant genotoxic effects in the first 24 h post intoxication, and the effects remained in the other periods analyzed (48, 72, and 96 h and 26 days of treatment). The DNA damage in peripheral blood cells, the number of erythrocytes with micronuclei, and polychromatic-to-normochromatic erythrocyte ratio were significantly reduced or absent in the piperine/AFB1 group. No significant differences were observed between the group piperine/AFB1 and the control and piperine-alone groups. The addition 60 mg·kg−1 of piperine to the diet of the broiler chicks was safe, promoting beneficial effects in poultry health with respect to the toxic effects 0.5 mg·AFB1·kg−1 body weight.

Published
2016
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110. Three-field versus two-field lymphadenectomy for esophageal squamous cell carcinoma: A long-term survival meta-analysis.

Author

Bona, Davide, Lombardo, Francesca, Matsushima, Kazuhide, Cavalli, Marta, Lastraioli, Caterina, Bonitta, Gianluca, Cirri, Silvia, Danelli, Piergiorgio, and Aiolfi, Alberto

Abstract

In the setting of esophageal squamous cell carcinoma, controversy exists regarding the optimal extent of lymphadenectomy, while conclusive evidence regarding the advantages of 3-field versus 2-field lymphadenectomy remains controversial. The purpose of the present meta-analysis was to investigate the effect of 3-field lymphadenectomy versus 2-field lymphadenectomy on overall survival. Systematic review and meta-analyses were computed to compare 3-field lymphadenectomy versus 2-field lymphadenectomy in the setting of esophageal squamous cell carcinoma. Risk ratio, weighted mean difference, hazard ratio, and restricted mean survival time difference were used as pooled effect size measures. Fourteen studies (3,431 patients) were included. Overall, 1,664 (48.8%) patients underwent 3-field lymphadenectomy, and 1,767 (51.5%) underwent 2-field lymphadenectomy. Three-field lymphadenectomy was associated with a significantly improved 5-year overall survival (hazard ratio: 0.80; 95% confidence interval 0.71–0.90; P <.001). The restricted mean survival time difference showed a statistically significant difference between 3-field lymphadenectomy versus 2-field lymphadenectomy up to 48 months (1.6 months; P =.04), however, no significant differences were found at 60-month follow-up (1.2 months; P =.14). No significant differences were found in term of postoperative mortality, anastomotic leak, pulmonary complications, chylothorax, and recurrent nerve palsy. For resectable esophageal squamous cell carcinoma, 3-field lymphadenectomy seems associated with a slight trend toward improved 5-year overall survival; however, its clinical benefit remains limited. [ABSTRACT FROM AUTHOR]

Published
2022
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112. Correspondence

Author

Monestiroli, U. M., Bondurri, A., Gandini, F., Lenna, G., Vellini, S., Danelli, P., Costamagna, D., Spinelli, A., Sandru, R., Mioli, P. R., Pintor, M. P., and Bona, R.

Published
2007
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114. 7th Educational Meeting 'Anal fistula: news and dilemmas' Rome, 20 November, 2018 : Presidents: Filippo La Torre, Giovanni Milito

Author

Zaffaroni, G., Bondurri, A., Guerci, C., Danelli, P. G., Bonomo, L. D., D’Anna, M. R., Arezzo, A., Falletto, E., Morino, M., D’Ascanio, F., Rizza, V., Marinelli, S., Pietroletti, R., Giacomel, G., Stocco, E., Bellomo, R., Infantino, A., Lobascio, P., Balducci, G., Fedele, S., Minafra, M., Laforgia, R., Musa, N., De Giorgi, C., Palasciano, N., Giuliani, A., Romano, L., Maffione, F., Schietroma, M., Carlei, F., Testa, A., Termine, L., Verdi, A., Garbarino, C., Heydari, A., Semprebon, G., Losi, L., Annesi, E., Passannanti, D., Bambi, L., Ceccarelli, D., Grimaldi, M. R., Telesco, D., Gaj, F., Benucci, F., Angiolini, M. R., Maconi, G., and Pisegna Cerone, L.

Published
2018

119. In COVID-19, NLRP3inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a nomothetic network approach

Author

Maes, Michael, Tedesco Junior, Walton Luiz Del, Lozovoy, Marcell Alysson Batisti, Mori, Mayara Tiemi Enokida, Danelli, Tiago, Almeida, Elaine Regina Delicato de, Tejo, Alexandre Mestre, Tano, Zuleica Naomi, Reiche, Edna Maria Vissoci, and Simão, Andréa Name Colado

Abstract

In coronavirus disease (COVID-19), the nucleotide-binding domain, leucine-rich repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated in response to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Acute infections are accompanied by a sickness symptom complex (SSC) which is highly conserved and protects against infections and hyperinflammation. The aim of this study is to delineate the associations of COVID-19, SSC and NLPR3 rs10157379 T> Cand NLPR3 rs10754558 C> Gvariants; and the protective role of SSC in SARS-CoV-2 infection. We recruited COVID-19 patients, 308 with critical, 63 with moderate and 157 with mild disease. Increased SSC protects against SARS, critical disease, and death due to COVID-19. Increasing age, male sex and rs10754558 CGsignificantly reduce SSC protection. The rs10157379 CTand rs10754558 GGgenotypes are positively associated with SARS. Partial Least Squares analysis shows that a) 41.8% of the variance in critical COVID-19 symptoms is explained by SSC and oxygen saturation (inversely associated), inflammation, chest computed tomography abnormalities, increased body mass index, SARS and age (positively associated); and b) the effects of the NLRP3 rs10157379and rs10754558variants on critical COVID-19 are mediated via SSC (protective) and SARS (detrimental). SSC includes anosmia and dysgeusia, and maybe gastrointestinal symptoms. In conclusion, intersections among the rs10754558 variant, age, and sex increase risk towards critical COVID-19 by attenuating SSC. NLRP3variants play an important role in SARS, and severe and critical COVID-19 especially in elderly male individuals with reduced SSC and with increased BMI, hypertension, and diabetes type 2.

Published
2022
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120. Identificação molecular de Mycoplasma mycoides subesp. mycoides tipo SC ioslado do conduto auditivo externo de caprinos clinicamente saudáveis

Author

Lucieri Olegário Pereira, Maria das Graças Miranda Danelli, Carlos Mazur, and Ricardo Galler

Subjects
Mycoplasma mycoides subesp. mycoides Tipo SC, caprino, identificação PCR, Brasil, Agriculture, Agriculture (General), S1-972
Abstract

O trabalho relata a presença de Mycoplasma mycoides subesp. mycoides Tipo SC, biótipo bovino, em caprinos clinicamente saudáveis no Estado do Rio de Janeiro, Brasil, identificado por PCR.

Published
2003
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122. Laparoscopy in management of appendicitis in high, middle and low income countries: A multicenter, prospective, cohort study

Author

Drake, TM, Camilleri-Brennan, J, Tabiri, S, Fergusson, SJ, Spence, R, Fitzgerald, JEF, Bhangu, A, Harrison, EM, Ademuyiwa, AO, Fergusson, S, Glasbey, JC, Khatri, C, Mohan, M, Nepogodiev, D, Soreide, K, Gobin, N, Freitas, AV, Hall, N, Kim, S-H, Negida, A, Jaffry, Z, Chapman, SJ, Arnaud, AP, Recinos, G, Manipal, CE, Amandito, R, Shawki, M, Hanrahan, M, Pata, F, Zilinskas, J, Roslani, AC, Goh, CC, Irwin, G, Shu, S, Luque, L, Shiwani, H, Altamimi, A, Alsaggaf, MU, Rayne, S, Jeyakumar, J, Cengiz, Y, Raptis, DA, Fermani, C, Balmaceda, R, Marta Modolo, M, Macdermid, E, Chenn, R, Yong, CO, Edye, M, Jarmin, M, D'amours, SK, Iyer, D, Youssef, D, Phillips, N, Brown, J, George, R, Koh, C, Warren, O, Hanley, I, Dickfos, M, Nawara, C, Oefner, D, Primavesi, F, Mitul, AR, Mahmud, K, Hussain, M, Hakim, H, Kumar, T, Oosterkamp, A, Assouto, PA, Lawani, I, Souaibou, YI, Tun, AK, Chong, CL, Devadasar, GH, Qadir, MRM, Aung, KP, Yeo, LS, Palomino Castillo, VD, Munhoz, MM, Moreira, G, Barros De Castro Segundo, LC, Khouri Ferreira, SA, Careta, MC, Kim, SB, De Sousa, AV, Lazzarini Cury, AD, Soares Miguel, GP, Carreiro De Freitas, AV, Silvestre, BP, Pinto Vianna, JG, Felipe, CO, Valente Laufer, LA, Altoe, F, Da Silva, LA, Pimenta, ML, Giuriato, TF, Bezerra Morais, PA, Luiz, JS, Araujo, R, Menegussi, J, Leal, M, Barroso de Lima, CV, Tatagiba, LS, Leal, A, Dos Santos, DV, Fraga, GP, Simoes, RL, Stock, S, Nigo, S, Kabba, J, Ngwa, TE, King, S, Zani, A, Azzie, G, Firdouse, M, Kushwaha, S, Agarwal, A, Bailey, K, Cameron, B, Livingston, M, Horobjowsky, A, Deckelbaum, DL, Razek, T, Marinkovic, B, Grasset, E, D'aguzan, N, Jimenez, J, Macchiavello, R, Zhang, Z, Guo, W, Oh, J, Zheng, F, Montes, I, Sierra, S, Mendez, M, Isabel Villegas, M, Mendoza Arango, MC, Mendoza, I, Naranjo Aristizabal, FA, Montoya Botero, JA, Quintero Riaza, VM, Restrepo, J, Morales, C, Cruz, H, Munera, A, Karlo, R, Domini, E, Mihanovic, J, Radic, M, Zamarin, K, Pezelj, N, Hache-Marliere, M, Batista Lemaire, S, Rivas, R, Khyrallh, A, Hassan, A, Shimy, G, Fahmy, MAB, Nabawi, A, Elfil, M, Ghoneem, M, Gohar, ME-SAM, Asal, M, Abdelkader, M, Gomah, M, Rashwan, H, Karkeet, M, Gomaa, A, Hasan, A, Elgebaly, A, Saleh, O, Fattah, AA, Gouda, A, Elshafay, AE, Gharib, A, Menshawy, A, Hanafy, M, Al-Mallah, A, Abdulgawad, M, Baheeg, M, Alhendy, M, AbdelFattah, I, Kenibar, A, Osman, O, Gemeah, M, Mohammed, A, Adel, A, Sayed, A, Abozaid, M, Kotb, AHE-B, Ata, AAA, Nasr, M, Alkammash, A, Saeed, M, Abd El Hamid, N, Attia, AM, Abd El Galeel, A, Elbanby, E, El-Dien, KS, Hantour, U, Alahmady, O, Mansour, B, Elkorashy, AM, Taha, EMS, Lasheen, KT, Elkolaly, SS, Abdel-Wahab, NYE, Abozyed, MAF, Saeed, AM, El Sayed, GS, Youssif, JH, Ahmed, SM, El-Shahat, NS, Khedr, AE-RH, Elsebaaye, AO, Elzayat, M, Abdelraheim, M, Elzayat, I, Warda, M, El Deen, KN, Elnemr, AE, Salah, O, Abbas, M, Rashad, M, Elzayyat, I, Hemeda, D, Tawfik, G, Salama, M, Khaled, H, Seisa, M, Elshaer, K, Hussein, A, Elkhadrawi, M, Afifi, AM, Ebrahim, OS, Metwally, MM, Elmelegy, R, Elsawahly, DME, Safa, H, Nofal, E, Elbermawy, M, Ghazy, AA, Samih, H, Abdelgelil, A, Abdelghany, S, El Kholy, A, Aboraya, M, Elkady, F, Salma, M, Samy, S, Fakher, R, Aboarab, A, Samir, A, Sakr, A, Haroun, A, Al-Aarag, AA-R, Elkholy, A, Elshanwany, S, Ghanem, E, Tammam, A, Hammad, AM, El Shoura, Y, El Ashal, G, Khairy, H, Antar, S, Mehrez, S, Abdelshafy, M, Hamad, MGM, Hosh, M, Abdallah, E, Magdy, B, Alzayat, T, Gamaly, E, Elfeki, H, Abouzahra, A, Elsheikh, S, Elgendy, FI, Abd El-Salam, F, Seifelnasr, O, Ammar, M, Eysa, A, Sadek, A, Toeema, AG, Nasr, A, Abuseif, M, Zidan, H, Barakat, SAE, Elsayed, N, Abd Elrasoul, Y, Elkelany, A, Ammar, MS, Mustafa, M-A, Hegazy, Y, Etman, M, Saad, S, Alrahawy, M, Raslan, A, Morsi, M, Rslan, A, Sabry, A, Elwakil, H, Shaker, H, Abd-Elrasoul, Y, El-Kashef, H, Shaalan, M, Tarek, A, Elwan, A, Nayel, AR, Seif, M, Emadeldin, D, Ghonaim, MA, Almallah, A, Fouad, A, Sayma, EA, Elbatahgy, A, El-Ma'doul, AS, Mosad, A, Tolba, H, Elsorogy, DEAA, Mostafa, HA, Omar, AA, Abd El Hameed, OS, Lasheen, A, Abd El Salam, Y, Morsi, A, Ismail, M, El-badawy, HA, Amer, MA, El-Hamouly, AS, Attallah, NA, Mosalum, O, Afandy, A, Mokhtar, A, Abouelnasr, A, Ayad, S, Shaker, R, Sakr, R, Amreia, M, Elsobky, S, Mustafa, M, El Magd, AA, Marey, A, Hafez, AT, Zalabia, MF, Mohamed, MM, Fadel, A, Ahmed, EA, Ali, A, Alwafai, MG, Dwydar, A, Kharsa, S, Mamdouh, E, El-Sheemy, H, AlYoussef, I, Aly, AK, Aldalaq, A, Alnawam, E, Alkhabbaz, D, Saad, M, Hussein, S, Elazayem, AA, Meshref, A, Elashmawy, M, Mousa, M, Nashaat, A, Ghanem, S, Elsayed, ZM, Elwaey, A, Elkadsh, I, Darweesh, M, Mohameden, A, Hafez, M, Badr, A, Badwy, A, Abd El Slam, M, Elazoul, M, Al-Nahrawi, S, Eldamaty, L, Nada, F, Ameen, M, Hagar, A, Elsehimy, M, Dawoud, H, El Mesery, S, El Gendy, A, Abdelkareem, A, Marey, AS, Allam, M, Shehata, S, Abozeid, K, Elshobary, M, Fahiem, A, Sarsik, S, Hashish, A, Zidan, M, Hashish, M, Aql, S, Elhendawy, AOA, Husseini, M, Kasem, E, Gheith, A, Elfouly, Y, Soliman, AR, Ibrahim, Y, Elfouly, N, Fawzy, A, Rashid, M, Elsherbiny, AS, Sieda, B, Badwi, NM, Mohammed, MMH, Mohamed, O, Habeeb, MA, Worku, M, Starr, N, Desta, S, Wondimu, S, Abebe, NS, Thomas, E, Asele, FA, Dabessa, D, Zerihun, AB, Mentula, P, Leppaniemi, A, Sallinen, V, Scalabre, A, Frade, F, Irtan, S, Graffeille, V, Gaignard, E, Alimi, Q, Graffieille, V, Abbo, O, Mouttalib, S, Bouali, O, Hervieux, E, Aigrain, Y, Botto, N, Faure, A, Fievet, L, Panait, N, Eyssartier, E, Schmitt, F, Podevin, G, Parent, V, Martin, A, Muller, C, Bonnard, A, Peycelon, M, Abantanga, F, Boakye-Yiadom, K, Bukari, M, Owusu, F, Awuku-Asabre, J, Bray, LD, Lytras, D, Psarianos, K, Bamicha, A, Kefalidi, E, Gemenetzis, G, Dervenis, C, Gouvas, N, Agalianos, C, Kontos, M, Kouraklis, G, Karousos, D, Germanos, S, Marinos, C, Anthoulakis, C, Nikoloudis, N, Mitroudis, N, Estupinian, S, Forno, W, Arevalo Azmitia, JR, Ramarez Cabrera, CC, Guevara, R, Aguilera, M, Mendez, N, Azmitia Mendizabal, CA, Ramazzini, P, Contreras Urquizu, M, Tale, F, Soley, R, Barrios, E, Marroquin Rodriguez, DE, Perez Velasquez, CI, Contreras Merida, SM, Regalado, F, Lopez, M, Siguantay, M, Lam, FY, Szeto, KJ-Y, Szeto, CCL, Li, WS, Li, KKK, Leung, MF, Mak, T, Ng, S, Prasad, SS, Kirishnan, A, Gyanchandani, N, Kumar, BS, Rangarajan, M, Bhat, S, Sreedharan, A, Kinnera, SV, Reddy, Y, Venugopal, C, Kumar, S, Mittal, A, Nadkarni, S, Lakshmi, HN, Malik, P, Limaye, N, Pai, S, Jain, P, Khajanchi, M, Satoskar, S, Satoskar, R, Bin Mahamood, A, Sutanto, EPR, Soeselo, DA, Tedjaatmadja, C, Rahmawati, FN, Mayasari, M, Al-Hasani, RKMJ, Al-Hameedi, HII, Ibraheem, HI, Al-Azraqi, IAA, Sabeeh, L, Kamil, R, Telfah, MM, Rasendran, A, Sheehan, J, Kerley, R, Normile, C, Gilbert, RW, Song, J, Dablouk, M, Mauro, L, Dablouk, MO, Kielty, P, Marks, E, Gosling, S, Mccarthy, M, Mirghani, D, Naqvi, SA, Wong, CS, Chung, S, D'cruz, R, Cahill, R, Gosling, SG, Fahy, C, Cadogan, DD, Powell, A, Gilbert, R, Clifford, C, Driscoll, A, Paul, S, Lee, C, Bowe, R, Hutch, W, Mohan, H, O'neill, M, Mealy, K, Danelli, P, Bondurri, A, Maffioli, A, Pasini, M, Pata, G, Roncali, S, Silvani, P, Carlucci, M, Faccincani, R, Bonavina, L, Macchitella, Y, Ceriani, C, Tugnoli, G, Di Saverio, S, Khattab, K, Paludi, MA, Pata, D, Cloro, LM, Allegri, A, Ansaloni, L, Coccolini, F, Veronese, E, Bortolasi, L, Hasheminia, A, Nastri, G, Dal Canto, M, Cucumazzo, S, Benevento, A, Tessera, G, Grandinetti, PP, Maniscalco, A, Lamanna, GL, Turati, L, Sgroi, G, Rausa, E, Villa, R, Monteleone, M, Merlini, D, Grassi, V, Cirocchi, R, Cacurri, A, Waleed, H, Diab, A, Elzowawi, F, Jokubauskas, M, Varkalys, K, Venskutonis, D, Pranevicius, R, Ambrozeviciute, V, Juciute, S, Skardziukaite, A, Bradulskis, S, Urbanavicius, L, Austraite, A, Riauka, R, Dambrauskas, Z, Karumnas, P, Urniezius, Z, Zilinskiene, R, Rudzenskaite, A, Usaityte, A, Montrimaite, M, Kaselis, N, Strazdas, A, Jokubonis, K, Maceviciute, K, Beisa, V, Poskus, T, Strupas, K, Laugzemys, E, Kolosov, A, Jotautas, V, Rakita, I, Mikalauskas, S, Kazanavicius, D, Rackauskas, R, Rakauskas, R, Preckailaite, E, Coomber, R, Johnson, K, Nowers, J, Periasammy, D, Salleh, A, Das, A, Tze, RGE, Kumar, MN, Abdullah, NAN, Kosai, NR, Taher, M, Rajan, R, Chong, HY, Agius, M, Borg, E, Bezzina, M, Bugeja, R, Vella-Baldacchino, M, Spina, A, Psaila, J, Francois-Coridon, H, Tolg, C, Colombani, J-F, Diaz-Zorrilla, C, Ramos-De La Medina, A, Corro-Diaz Gonzalez, S, Jacobe, M, Mapasse, D, Snyder, E, Oumer, R, Osman, M, Mohammad, A, Anyanwu, L-J, Sheshe, A, Adesina, A, Faturoti, O, Taiwo, O, Ibrahim, MH, Nasir, AA, Suleiman, SI, Adeniyi, A, Adesanya, O, Adebanjo, A, Osuoji, R, Atobatele, K, Ogunyemi, A, Williams, O, Oludara, M, Oshodi, O, Ademuyiwa, A, Lawal, AO, Alakaloko, F, Elebute, O, Osinowo, A, Bode, C, Adesuyi, A, Tade, A, Adekoya, A, Nwokoro, C, Ayandipo, OO, Lawal, TA, Ajao, AE, Ali, SS, Odeyemi, B, Olori, S, Popoola, A, Adeyeye, A, Adeniran, J, Lossius, WJ, Havemann, I, Thorsen, K, Narvestad, JK, Wold, TB, Nymo, L, Elsiddig, 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Gasteratos, K, Vimalachandran, D, Magee, C, Mcguigan, A, Mcaleer, S, Morgan, C, Braungart, S, Lafferty, K, Labib, P, Tanase, A, Mangan, C, Reza, L, Woodward, H, Gouldthorpe, C, Turner, M, Wild, JRL, Malik, TAM, Proctor, VK, Hewage, K, Davies, J, Dubois, A, Sarwary, S, Zardab, A, Grant, A, Mcintyre, R, Mogan, YP, Ho, W, Chong, BFHK, Tewari, S, Humm, G, Farinella, E, Hall, NJ, Wright, NJ, Major, CP, Xerri, T, Amin, J, Farhad, M, Camilleri-Brennan, JF, Robertson, AGN, Swann, J, Richards, J, Jabbar, A, De Bono, P, Attard, M, Burns, H, Macdonald, E, Baldacchino, M, Skehan, J, Hall, TF, Gimzewska, M, Mclachlan, G, Shah, J, Giles, J, Chiu, S, Weber, B, Chiu, SMY, Highcock, S, Hassan, M, Beasley, W, Vlachogiorgos, A, Dias, S, Maharaj, G, Mcdonald, R, Macdonald, A, Witherspoon, P, Baird, A, Sarmah, P, Green, N, Youssef, H, Cross, K, Rees, CM, Van Duren, B, Upchurch, E, Khan, K, Abudeeb, H, Hammad, A, Karandikar, S, Bowley, D, Karim, A, Chachulski, W, Richardson, L, Dawnay, G, Thompson, B, Mistry, A, Ghetia, M, Roy, S, Al-Obaedi, O, Das, K, Prabhudesai, A, Cocker, DM, Tan, JJ, Tyler, R, Di Franco, F, Ayyar, S, Vivekanantham, S, Gokani, S, Gillespie, M, Gudlaugsdottir, K, Pezas, T, Currow, C, Kim, MY-H, Birring, A, Edwards, J, Das, S, Jha, M, Atkinson, K, Luck, J, Fozard, T, Puttick, M, Salama, Y, Shah, R, Ibrahem, AA, Ebdewi, H, Gravante, G, El-Rabaa, S, Nnajiuba, H, Allott, R, Bhargava, A, Chan, Z, Hassan, Z, Makinde, M, Hemingway, D, Dean, R, Boddy, A, Aber, A, Patel, V, Parakh, J, Parthiban, S, Ubhi, HK, Hosein, S-P, Ward, S, Malik, K, Jennings, L, Newton, T, Alkhouri, M, Kang, MK, Houlden, C, Barry, J, Raza, I, Farquharson, A, Bhattacharya, S, Chang, K, Wilson, MSJ, Neo, YN, Ibrahim, I, Chan, E, Peck, FS, Lim, PJ, North, AS, Blundell, R, Williamson, A, Fouad, D, Minocha, A, Mccarthy, K, Court, E, Chambers, A, Yee, J, Tham, JC, Beaton, C, Walsh, U, Lockey, J, Bokhari, S, Howells, L, Griffiths, M, Yallop, L, Singh, S, Nasher, O, Jackson, P, Shariffuddin, AM, Ho, WC, Pabla, G, Ramzi, S, Zeidan, S, Doughty, J, Sinha, S, Davenport, R, Lewis, J, Duffy, L, Mcaleer, E, Williams, E, Som, R, Javed, O, Boal, M, Harrison, N, Tafazal, H, Brogden, T, Griffiths, E, Obute, RD, Glover, TE, Clark, DJ, Boshnaq, M, Akhtar, M, Capleton, P, Doughan, S, Rabie, M, Mohamed, I, Samuel, D, Dickson, L, Kennedy, M, Dempster, E, Brown, E, Maple, N, Monaghan, E, Wolf, B, Garland, A, Mcphee, A, Anderson, D, Anderson, R, Hassan, S, Smith, D, Lund, J, Boereboom, C, Murphy, J, Tierney, G, Tou, S, Zimmermann, EF, Smart, NJ, Warwick, AM, Stasinou, T, Daniels, I, Findlay-Cooper, K, Mitrasinovic, S, Ray, S, Varcada, M, D'Souza, R, Omara, S, Spurr, M, Parkinson, L, Hanks, A, Ma, J, Abington, E, Ramcharn, M, Williams, G, Winstanley, J, Kennedy, ED, Yeung, ENW, Jones, C, O'neill, S, Lim, SJ, Liew, I, Nair, H, Fairfield, C, Koh, S, Wilson, A, Anandkumar, D, Kirupagaran, A, Jones, TF, Torrance, HDT, Fowler, AJ, Chandrakumar, C, Patel, P, Ashraf, SF, Lakhani, SM, Mclean, AL, Basson, S, Batt, J, Bowman, C, Stoddart, M, Benons, N, Mason, C, Harrison, R, Quayle, J, Barker, T, Summerour, V, Harper, E, Smith, C, Hampton, M, Pitt, SK, Ward, AE, O'Connor, T, Heywood, EG, Chowdhury, A, Hossaini, S, Watson, NFS, Mckechnie, D, Farah, A, Chun, A, Koh, H, Lim, G, Sunderland, G, Gould, L, Munipalle, PC, Rooney, H, Browning, DRL, Pereira, B, Nemeth, K, Decker, E, Giuliani, S, Shalaby, A, Shaikh, S, Tan, CY, Palkhi, EYA, Szczap, A, Chidambaram, S, Chen, CY, Kulasabanathan, K, Chhabra, S, Kostov, E, Harbord, P, Barnacle, J, Palliyil, MM, Zikry, M, Porter, J, Raslan, C, Hafiz, S, Soltani, N, Baillie, K, Singh, P, Sheth, S, Patel, K, Khalili, M, Choi, J, Benger, M, Marples, L, Macfarlane, A, Thurairaja, R, Boyce, T, Whewell, H, Jones, E, Th'ng, F, Robertson, N, Mirza, A, Saeed, H, Galloway, S, Elena, G, Afzal, M, Zakir, M, Sodde, P, Hand, C, Sriram, A, Clark, T, Holton, P, Livesey, A, Sinha, Y, Iqbal, FM, Bharj, IS, Rotundo, A, Jenvey, C, Slade, R, Golding, D, Haines, S, Abdullah, AAN, Tilston, TW, Loughran, D, Donoghue, D, Giacci, L, Sherif, MA, Harrison, P, Tang, A, Kotecha, D, Elshaer, M, Urbonas, T, Riaz, A, Chapman, A, Acharya, P, Shalhoub, J, Grossart, C, McMorran, D, Mlotshwa, M, Hawkins, W, Loizides, S, Krishna, K, Orchard, M, Ho, CW, Thomson, P, Khan, S, Taylor, F, Shukla, J, Howie, EE, Macdonald, L, Komolafe, O, Mcintyre, N, Cragg, J, Parker, J, Stewart, D, Lintin, L, Tracy, J, Farooq, T, Molina, G, Kaafarani, H, Beyene, R, Sava, J, Scott, M, Swaroop, M, Kennedy, R, Azodo, IA, Heffernan, D, Chun, T, Stephen, A, Sion, M, Weinstein, MS, Punja, V, Bugaev, N, Goodstein, M, Razmdjou, S, Etchill, E, Puyana, JC, Kesinger, M, Napolitano, L, To, K, Hemmila, M, Todd, O, Jenner, E, Hoogakker, E, Chen, JHC, Ismail, L, Roi, D, Escobar, EG, Clinicum, II kirurgian klinikka, Department of Surgery, Pertti Panula / Principal Investigator, HUS Abdominal Center, and OMÜ

Subjects
Male, SURGERY, Disease, 030230 surgery, DISEASE, 0302 clinical medicine, Risk Factors, Appendicitis, Appendectomy, Global surgery, Laparoscopic, Operative standards, Postoperative care, Postoperative complications, Surgical site infection, 80 and over, Medicine, Prospective Studies, appendectomy, appendicitis, global surgery, laparoscopic, operative standards, postoperative care, postoperative complications, surgical site infection, Prospective cohort study, Laparoscopy, Child, Aged, 80 and over, medicine.diagnostic_test, Middle Aged, 3. Good health, Treatment Outcome, 030220 oncology & carcinogenesis, Female, HEALTH, BURDEN, Life Sciences & Biomedicine, Adult, medicine.medical_specialty, Adolescent, Developing country, APPENDECTOMY, GlobalSurg Collaborative, Article, 03 medical and health sciences, Young Adult, Internal medicine, Surgery, Humans, Emergency appendectomy, Surgical emergency, Propensity Score, Developing Countries, Aged, Science & Technology, SURGICAL CARE, business.industry, Developed Countries, Kirurgi, 1103 Clinical Sciences, medicine.disease, 3126 Surgery, anesthesiology, intensive care, radiology, Emergencies, Follow-Up Studies, Postoperative Complications, business
Abstract

Mak, Tony W. C./0000-0002-4516-3124; Peycelon, Matthieu/0000-0003-3617-4849; Ng, Simon S. M./0000-0002-5389-9297; Negida, Ahmed/0000-0001-5363-6369; Di Saverio, Salomone/0000-0001-5685-5022; Poskus, Tomas/0000-0002-6931-6041; Mihanovic, Jakov/0000-0001-6450-2956; Lund, Jonathan/0000-0001-5195-2181; Alshara, Ahmed/0000-0002-8127-3873; Maffioli, Anna/0000-0001-7116-4019; Smart, Neil/0000-0002-3043-8324; Roslani, April Camilla/0000-0003-2458-965X; Elfeki, Hossam/0000-0003-0704-4068; Samaraweera, Dulan/0000-0001-8334-8157; Mironescu, Aurel/0000-0003-1827-6948; Gemeah, Mostafa/0000-0002-9145-9348; Antar, Sarah/0000-0001-6091-2835; Labib, Peter LZ/0000-0003-2362-9218; Nouh, Thamer/0000-0002-7118-7453; Soreide, Kjetil/0000-0001-7594-4354; Rabie, Mohamed A/0000-0001-7799-2931; Ansaloni, Luca/0000-0001-6427-0307; Pata, Francesco/0000-0003-2634-1199; Barneo, Luis/0000-0001-9410-4262; Fahmy, Mohamed/0000-0002-3570-1742; Coccolini, Federico/0000-0001-6364-4186; Mikalauskas, Saulius/0000-0002-5191-1491; ALI, EMAD ALI AHMED/0000-0003-4384-0934; Cirocchi, Roberto/0000-0002-2457-0636; Nepogodiev, Dmitri/0000-0002-2171-2862; Mitul, Ashrarur Rahman/0000-0002-7100-7723; Zalabia, Mohamed Fadel/0000-0003-2372-2914; Fahmy, Mohamed A Baky/0000-0002-3570-1742; Glasbey, James/0000-0001-7688-5018; Shaikh, Shafaque/0000-0002-4536-9595; Furqan, Muhammad Mohsin/0000-0003-0719-5069; Boddy, Alexander P/0000-0001-7243-0155; Vimalachandran, Dale/0000-0001-5817-8969; Iordache, Florin/0000-0001-7108-7279; Merlini, David A/0000-0002-7981-7149; Beuran, Mircea/0000-0002-0889-1675; Jaffry, Zahra/0000-0003-4101-2246; Hassan, Mariam/0000-0001-6160-9723; Mohan, Midhun/0000-0002-1865-8623; Germanos, Stylianos/0000-0002-1640-1226; afifi, ahmed/0000-0002-4294-8217; Alhendy, Mohammed/0000-0003-3434-1156; Ozkan, Bahar Busra/0000-0002-0939-8049; Todd, Oliver/0000-0001-7212-8095; Ali, Ased/0000-0001-9576-9047; Torrance, Hew David/0000-0002-3854-1748; Morsi, Mahmoud/0000-0002-6621-0751; Lawal, Taiwo Akeem/0000-0002-8632-5783; Bondurri, Andrea/0000-0002-6521-5876; Chapman, Stephen/0000-0003-2413-5690; morsi, mahmoud/0000-0001-6825-7361; Arman, Sam/0000-0001-9620-5171; Lopez, Crislee/0000-0002-8775-3675; van Duren, Bernard/0000-0003-1877-8227; Hanrahan, Michael/0000-0002-2358-5975; , paolo/0000-0001-9844-3149; Lim, Shujing Jane/0000-0003-4970-7405; Turati, Luca/0000-0002-6958-6682; Shehata, Sherif/0000-0002-9733-006X; LAWANI, Ismail/0000-0001-5022-6313; FAURE, alice/0000-0002-3327-6391; Attia, Attia/0000-0003-2602-7263; Tham, Ji Chung/0000-0003-1796-9347; Segovia Lohse, Helmut Alfredo/0000-0003-3255-5345; Sgroi, Giovanni/0000-0003-4956-124X; Mohammed, Mohammed Mustafa Hassan/0000-0003-3013-1792; Warren, Oliver/0000-0001-8948-7473; SHAWKI, Marwan/0000-0001-6053-5523; Abbo, Olivier/0000-0002-4202-4284; Fitzgerald, James/0000-0002-4453-5117; Thorell, Anders/0000-0001-7238-1728; Daniels, Ian/0000-0002-9114-0812; Khatri, Chetan/0000-0002-3961-1314; Hassanain, Mazen/0000-0002-2441-5142; Wright, Naomi/0000-0003-4105-8009; Elgebaly, Ahmed/0000-0002-8324-0960; Tanase, Andrei/0000-0001-9465-8302; IMOROU SOUAIBOU, Yacoubou/0000-0002-1908-6698; Scalabre, Aurelien/0000-0001-7361-1900; Pata, Giacomo/0000-0001-7867-9349; McGuigan, Andrew/0000-0002-5097-5063; Marshall, Dominic/0000-0002-3498-2511; Stoddart, Michael/0000-0001-7346-324X; Amandito, Radhian/0000-0002-1211-7973; Hammad, Ali/0000-0003-1894-3480; ZANI, AUGUSTO/0000-0003-2283-9846 WOS: 000438285100004 PubMed: 29623470 Background Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. Methods This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. Results 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). Conclusion A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. Trial registration: NCT02179112. DFID-MRC-Wellcome Trust Joint Global Health Trial Development Grant [MR/N022114/1]; Wellcome Trust Biomedical Vacation ScholarshipsWellcome Trust; National Institute of Health Research (NIHR) Global Health Research Unit GrantNational Institute for Health Research (NIHR) [NIHR 17-0799] Funded by a DFID-MRC-Wellcome Trust Joint Global Health Trial Development Grant (MR/N022114/1), a Wellcome Trust Biomedical Vacation Scholarships (2015), and a National Institute of Health Research (NIHR) Global Health Research Unit Grant (NIHR 17-0799). The views expressed are those of the authors and not necessarily those of the National Health Service, the NIHR, or the UK Department of Health and Social Care.

Published
2018

125. Pentanuclear Thorium(IV) Coordination Cluster from the Use of Di(2-pyridyl) Ketone

Author

Tsantis, Sokratis T., Danelli, Panagiota, Tzimopoulos, Demetrios I., Raptopoulou, Catherine P., Psycharis, Vassilis, and Perlepes, Spyros P.

Abstract

The Th(NO3)4·5H2O/di(2-pyridyl) ketone [(py)2CO] reaction system gives a pentanuclear cluster containing the doubly deprotonated form of the gem-diol derivative of the ligand. The cluster consists of a tetrahedral arrangement of four ThIVions centered on the fifth ion, which is the first characterized ThIV5complex. The analysis of its structure reveals that this is a Kuratowski-type coordination compound.

Published
2021
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127. Mortality of emergency abdominal surgery in high-, middle- and low-income countries

Author

J E, F Fitzgerald, Khatri, C, C Glasbey, J, Mohan, M, Lilford, R, M Harrison, E, Holmer, H, Hall, N, S-H, Kim, Negida, A, Jaffry, Z, J Chapman, S, Shu, S, Shiwani, H, Jeyakumar, J, Fermani, C, Balmaceda, R, M Marta Modolo, Macdermid, E, Gobin, N, Chenn, R, C Ou Yong, Edye, M, Jarmin, M, K D'amours, S, Iyer, D, Youssef, D, Phillips, N, Brown, J, George, R, Koh, C, Warren, O, Hanley, I, Dickfos, M, Nawara, C, Öfner, D, Primavesi, F, R Mitul, A, Mahmud, K, Hussain, M, Hakim, H, Kumar, T, Oosterkamp, A, A Assouto, P, Lawani, I, Y Imorou Souaibou, A Kyaw Tun, C Leung Chong, H Devadasar, G, M Rashid Minhas Qadir, K Phyo Aung, L Shi Yeo, D Palomino Castillo, V, M Moron Munhoz, Moreira, G, C Barros De Castro Segundo, L, S Anderson Khouri Ferreira, M Cassa Careta, S Binna Kim, A Venâncio De Sousa, A Daltri Lazzarini Cury, G Peixoto Soares Miguel, A Vega Carreiro De Freitas, B Pereira Silvestre, J Guasti Pinto Vianna, C Oliveira Felipe, L Alberto Valente Laufer, Altoe, F, L Ayres Da Silva, L Pimenta, M, T Fernandes Giuriato, P Alves Bezerra Morais, J Souza Luiz, Araujo, R, Menegussi, J, Leal, M, C Vinícius Barroso de Lima, L Sarmento Tatagiba, Leal, A, D Vinicius Dos Santos, G Pereira Fraga, R Lages Simoes, Stock, S, Nigo, S, Kabba, J, T Ebogo Ngwa, King, S, Zani, A, Azzie, G, Firdouse, M, Kushwaha, S, Agarwal, A, Bailey, K, Cameron, B, Livingston, M, Horobjowsky, A, L Deckelbaum, D, T Razek, B Marinkovic, Grasset, E, D'Aguzan, N, Jimenez, J, Macchiavello, R, Zhang, Z, Guo, W, J, Oh, Zheng, F, Montes, I, Sierra, S, Mendez, M, I Villegas, M, C Mendoza Arango, M, Mendoza, I, A Naranjo Aristizã Bal, F, A Montoya Botero, J, M Quintero Riaza, V, Restrepo, J, Morales, C, Cruz, H, Munera, A, Karlo, R, Domini, E, Mihanovic, J, Radic, M, Zamarin, K, Pezelj, N, Hache-Marliere, M, S Batista Lemaire, Rivas, R, Khyrallh, A, Hassan, A, Shimy, G, A Baky Fahmy, M, Nabawi, A, S Ali Muhammad Gohar, M, Elfil, M, Ghoneem, M, Asal, M, Abdelkader, M, Gomah, M, Rashwan, H, Karkeet, M, Gomaa, A, Hasan, A, Elgebaly, A, Azzam, O, Abdelfattah, A, Gouda, A, Elshafay, A, Gharib, A, Menshawy, A, Hanafy, M, Al-Mallah, A, Abdulgawad, M, Baheeg, M, Alhendy, M, A Fattah, I, Kenibar, A, Osman, O, Gemeah, M, Mohammed, A, Adel, A, Sayed, A, Abozaid, M, A Hafez El-Badri Kotb, A Ahmed Ata, A, Nasr, M, Alkammash, A, Saeed, M, N Abd El Hamid, M Attia, A, A Abd El Galeel, Elbanby, E, K Salah El-Dien, Hantour, U, Alahmady, O, Mansour, B, M Elkorashy, A, M Saeed Taha, E, T Lasheen, K, S Said Elkolaly, N Yosri Elsayed Abdel-Wahab, A Fathi Abozyed, M, M Saeed, A, G Samir El Sayed, H Youssif, J, S Magdy Ahmed, N Soubhy El-Shahat, A Hegazy Khedr, A Osama Elsebaaye, Elzayat, M, Abdelraheim, M, Elzayat, I, Warda, M, K Naser El Deen, A Essam Elnemr, Salah, O, Abbas, M, Rashad, M, Elzayyat, I, Hemeda, D, Tawfik, G, Salama, M, Khaled, H, Seisa, M, Elshaer, K, Hussein, A, Elkhadrawi, M, M Afifi, A, O Saadeldeen Ebrahim, M Metwally, M, Elmelegy, R, M Elbendary Elsawahly, D, Safa, H, Nofal, E, Elbermawy, M, M Abo Raya, A Abdelmotaleb Ghazy, Samih, H, Abdelgelil, A, Abdelghany, S, A El Kholy, Elkady, F, Salma, M, Samy, S, Fakher, R, Aboarab, A, Samir, A, Sakr, A, Haroun, A, A Abdel-Rahman Al-Aarag, Elkholy, A, Elshanwany, S, Ghanem, E, Tammam, A, M Hammad, A, Y El Shoura, G El Ashal, Khairy, H, Antar, S, Mehrez, S, Abdelshafy, M, M Gamal Mohamad Hamad, M Farid Hosh, Abdallah, E, Magdy, B, Alzayat, T, Gamaly, E, Elfeki, H, Abouzahra, A, Elsheikh, S, Elgendy, F, F Abd El-Salam, Seifelnasr, O, Ammar, M, Eysa, A, Sadek, A, A Gamal Toeema, Shady, K, Nasr, A, Abuseif, M, Zidan, H, S Abd Elmageed Barakat, Elsayed, N, Y Abd Elrasoul, Elkelany, A, M Sabry Ammar, Mustafa, M, Hegazy, Y, Etman, M, Saad, S, Alrahawy, M, Raslan, A, Morsi, M, Rslan, A, Sabry, A, Elwakil, H, Shaker, H, Abd-Elrasoul, Y, El-Kashef, H, Shaalan, M, Tarek, A, Elwan, A, A Ragab Nayel, Seif, M, Emadeldin, D, M Ali Ghonaim, Almallah, A, Fouad, A, E Adel Sayma, Elbatahgy, A, A Solaiman El-Ma'doul, Mosad, A, Tolba, H, A Amin Elsorogy, D, H Ali Mostafa, A Atef Omar, O Sherief Abd El Hameed, Lasheen, A, Y Abd El Salam, Morsi, A, Ismail, M, H Ahmed El-Badawy, Amer, M, A Sabry El-Hamouly, N Ahmed Attallah, Mosalum, O, Afandy, A, Mokhtar, A, Abouelnasr, A, Ayad, S, Shaker, R, Sakr, R, Amreia, M, Elsobky, S, A Abo El Magd, Marey, A, A Tarek Hafez, Zalabia, M, M Moamen Mohamed, Fadel, A, E Ali Ahmed, Ali, A, M Ghassan Alwafai, Dwydar, A, Kharsa, S, Mamdouh, E, El-Sheemy, H, Youssef, I, A Khairy Aly, Aldalaq, A, Alnawam, E, Alkhabbaz, D, Saad, M, Hussein, S, A Abo Elazayem, Ramadan, A, Elashmawy, M, Mousa, M, Nashaat, A, Ghanem, S, Oof, Z, Elwaey, A, Elkadsh, I, Darweesh, M, Mohameden, A, Hafez, M, Badr, A, Badwy, A, M Abd El Slam, Elazoul, M, Al-Nahrawi, S, Eldamaty, L, Nada, F, Ameen, M, Hagar, A, Elsehimy, M, Aboraya, M, Dawoud, H, S El Mesery, A El Gendy, Abdelkareem, A, A Safwan Marey, Allam, M, Shehata, S, Abozeid, K, Elshobary, M, Fahiem, A, Sarsik, S, Hashish, A, Zidan, M, Hashish, M, Sanad, A, Mesalam, M, Aql, S, A Osman Abdelaziz Elhendawy, Husseini, M, Kasem, E, Gheith, A, Elfouly, Y, A Ragab Soliman, Ibrahim, Y, Elfouly, N, Fawzy, A, Rashid, M, A Salah Elsherbiny, Sieda, B, Badwi, N, M Hassan Mohammed, M, Mohamed, O, M Abdulkhalek Habeeb, Worku, M, Starr, N, Desta, S, Wondimu, S, S Abebe, N, Thomas, E, A Asele, F, Dabessa, D, N Seyoum Abebe, B Zerihun, A, Mentula, P, Leppäniemi, A, Sallinen, V, Scalabre, A, Frade, F, Irtan, S, Graffeille, V, Gaignard, E, Alimi, Q, Graffieille, V, Abbo, O, Mouttalib, S, Bouali, O, Hervieux, E, Aigrain, Y, Botto, N, Faure, A, Fievet, L, Panait, N, Eyssartier, E, Schmitt, F, Podevin, G, Parent, V, Martin, A, P Arnaud, A, Muller, C, Bonnard, A, Peycelon, M, Abantanga, F, Boakye-Yiadom, K, Bukari, M, Owusu, F, Awuku-Asabre, J, Tabiri, S, D Bray, L, Lytras, D, Psarianos, K, Bamicha, A, Kefalidi, E, Gemenetzis, G, Dervenis, C, Gouvas, N, Agalianos, C, Kontos, M, Kouraklis, G, Karousos, D, Germanos, S, Marinos, C, Anthoulakis, C, Nikoloudis, N, S Mitroudis, N, Recinos, G, Estupinian, S, Forno, W, R Arévalo Azmitia, J, C Ramã Rez Cabrera, C, Guevara, R, Aguilera, M, Mendez, N, A Azmitia Mendizabal, C, Ramazzini, P, M Contreras Urquizu, Tale, F, Soley, R, Barrios, E, E Marroquín Rodríguez, D, I Pérez Velásquez, C, M Contreras Mérida, S, Regalado, F, Lopez, M, Siguantay, M, Y Lam, F, K J-Y Szeto, C C, L Szeto, S Li, W, K K, K Li, F Leung, M, Mak, T, S, Ng, S Prasad, S, Kirishnan, A, Gyanchandani, N, Bhat, S, Sreedharan, A, V Kinnera, S, S Kumar, B, Rangarajan, M, Reddy, Y, Venugopal, C, Kumar, S, Mittal, A, Nadkarni, S, N Lakshmi, H, Malik, P, Limaye, N, Pai, S, Jain, P, Khajanchi, M, Satoskar, S, Satoskar, R, Abid Bin Mahamood, P Refianti Sutanto, E, A Soeselo, D, Tedjaatmadja, C, N Rahmawati, F, Amandito, R, Mayasari, M, R K, M Jawad Al-Hasani, I Ibraheem Al-Hameedi, H, A Aziz Al-Azraqi, I, Sabeeh, L, Kamil, R, Shawki, M, M Mezeil Telfah, Rasendran, A, Sheehan, J, Kerley, R, Normile, C, W Gilbert, R, Song, J, Dablouk, M, Mauro, L, O Dablouk, M, Hanrahan, M, Kielty, P, Marks, E, Gosling, S, Mccarthy, M, Mirghani, D, S Altaf Naqvi, S Wong, C, Chung, S, D'Cruz, R, Cahill, R, G Gosling, S, Fahy, C, D Duarte Cadogan, Powell, A, Gilbert, R, Clifford, C, Driscoll, A, Stassen, P, Lee, C, Bowe, R, Hutch, W, Mohan, H, O'Neill, M, Mealy, K, Danelli, P, Bondurri, A, Maffioli, A, Pasini, M, Pata, G, Roncali, S, Silvani, P, Carlucci, M, Faccincani, R, Bonavina, L, Macchitella, Y, Ceriani, C, Tugnoli, G, S Di Saverio, Khattab, K, M Angel Paludi, Pata, D, L Maria Cloro, Allegri, A, Ansaloni, L, Coccolini, F, Veronese, E, Bortolasi, L, Hasheminia, A, Nastri, G, M Dal Canto, Cucumazzo, S, Pata, F, Benevento, A, Tessera, G, P Paolo Grandinetti, Maniscalco, A, G Luca Lamanna, Turati, L, Sgroi, G, Rausa, E, Villa, R, Monteleone, M, Merlini, D, Grassi, V, Cirocchi, R, Cacurri, A, Waleed, H, Diab, A, Elzowawi, F, Jokubauskas, M, Varkalys, K, Venskutonis, D, Pranevicius, R, Ambrozeviciute, V, Juciute, S, Skardžiukaitė, A, Bradulskis, S, Urbanavicius, L, Austraite, A, Riauka, R, Zilinskas, J, Dambrauskas, Z, Karumnas, P, Urniezius, Z, Zilinskiene, R, Rudzenskaite, A, Usaityte, A, Montrimaite, M, Kaselis, N, Strazdas, A, Jokubonis, K, Maceviciute, K, Laugzemys, E, Kolosov, A, Jotautas, V, Rakita, I, Mikalauskas, S, Kazanavicius, D, Rackauskas, R, Strupas, K, Poskus, T, Beisa, V, Rakauskas, R, Preckailaite, E, Coomber, R, Johnson, K, Nowers, J, Periasammy, D, Salleh, A, Das, A, R Goh Ern Tze, M Nirumal Kumar, A Nik Abdullah, N, R Kosai, N, Taher, M, Rajan, R, Y Chong, H, C Roslani, A, C Goh, C, Agius, M, Borg, E, Bezzina, M, Bugeja, R, Vella-Baldacchino, M, Spina, A, Psaila, J, Francois-Coridon, H, Tolg, C, J-F, Colombani, Diaz-Zorrilla, C, A Ramos-De La Medina, S Corro-Diaz Gonzalez, Jacobe, M, Mapasse, D, Snyder, E, Oumer, R, Osman, M, Mohammad, A, L-J, Anyanwu, Sheshe, A, Adesina, A, Faturoti, O, Taiwo, O, M Habib Ibrahim, A Nasir, A, S Itopa Suleiman, Adeniyi, A, Adesanya, O, Adebanjo, A, Osuoji, R, Atobatele, K, Ogunyemi, A, Wiliams, O, Oludara, M, Oshodi, O, Ademuyiwa, A, A Oluwagbemiga Lawal, Alakaloko, F, Elebute, O, Osinowo, A, Bode, C, Adesuyi, A, Tade, A, Adekoya, A, Nwokoro, C, O Ayandipo, O, T Akeem Lawal, E Ajao, A, S Sani Ali, Odeyemi, B, Olori, S, Popoola, A, Adeyeye, A, Adeniran, J, J Lossius, W, Havemann, I, Thorsen, K, K Narvestad, J, Søreide, K, B Wold, T, Nymo, L, Elsiddig, M, Dar, M, F Bhopal, K, Iftikhar, Z, M Furqan, M, Nighat, B, Jawaid, M, Khalique, A, Zil-E-Ali, A, Rashid, A, H Abbas Dharamshi, Naqvi, T, Faraz, A, W Anwar, A, T Muhammad Yaseen, S Shamsi, G, Yaseen, T, Anwer, W, H Paredes Decoud, Aguilera, O, I Zelada Alvarez, I, J Marcelo Delgado, M Machain Vega, G, A Segovia Lohse, H, L Messa Aguilar, W, A Cabala Chiong, J, C Manchego Bautista, A, Huaman, E, Zegarra, S, Camacho, R, M Vergara Celis, J, A Romani Pozo, D, Hamasaki, J, Temoche, E, Herrera-Matta, J, P García Torres, C, M Alvarez Barreda, L, R Barrionuevo Ojeda, Garaycochea, O, M Castro Mollo, M Linares Delgado, Fujii, F, A Durand, S, A Arroyo Basto, C, M Urbina Rojas, N, B Shu Yip, S, L Contreras Vergara, A, A Echevarria Rosas Moran, G Borda Luque, M Rodriguez Castro, R Alvarado Jaramillo, G Manrique Sila, E Lopez, C, M Zapata Ponze De Leon, Machaca, M, R Coasaca Huaraya, Arenas, A, López, C, C Milagros Herrera Puma, Pino, W, Hinojosa, C, Limache, S, G Manrrique Sila, L-A Mercado Rodriguez, Melo, R, Costa-Maia, J, Muralha, N, Sauvat, F, Dan, I, Hogea, M, Eduard, P, R-M, Bratu, Beuran, M, I-B, Diaconescu, B-V, Martian, F-M, Iordache, Vartic, M, C Vida, L, I Muntean, L, S Mironescu, A, V J, P Nsengimana, Niragire, A, J D L, C Allen Ingabire, Niyirera, E, Zanini, N, Jovine, E, Landolfo, G, N Alomar, I, A Alnuqaydan, S, M Altwigry, A, Othman, M, Osman, N, Alqahtani, E, Alzahrani, M, Alyami, R, Aljohani, E, Alhabli, I, Mikwar, Z, Almuallem, S, Nawawi, A, Bakhaidar, M, A Maghrabi, A, Alsaggaf, M, Aljiffry, M, Altaf, A, Khoja, A, Habeebullah, A, Akeel, N, Ghandora, N, Almoflihi, A, Huwait, A, Al-Shammari, A, Al-Mousa, M, Alghamdi, M, Adham, W, Albeladi, B, A Alfarsi, M, Mahdi, A, S Al Awwad, Altamimi, A, Nouh, T, Hassanain, M, Aldhafeeri, S, Sadig, N, Algohary, O, Aledrisy, M, Gudal, A, Alrifaie, A, Alrowais, M, Althwainy, A, Shabkah, A, Alamoudi, U, Alrajraji, M, Alghamdi, B, Aljohani, S, Daqeeq, A, J Al-Faifi, J, Jennings, V, Ngayu, N, Moore, R, Kong, V, Kretzmann, H, Connor, K, Nel, D, Sampson, C, Spence, R, Panieri, E, Rayne, S, Sishuba, N, Tun, M, M Mphatsoe, A, A Carreira, J, Teasdale, E, Wagener, M, Botes, S, D Du Plessis, Fernandez-Bueno, F, Aguilar-Jimenez, J, A Garcia-Marin, J, S García, L, J García Florez, L, R Darío Arias Pacheco, Pagnozzi, J, H Jara Quezada, J, L Rodicio, J, Minguez, G, Rodríguez-Uría, R, Ugalde, P, Lopez-Arevalo, C, Barneo, L, P Gonzales Stuva, J, Ortega-Vazquez, I, Rodriguez, L, Herrera, N, P Pitigala Arachchi, W S, M Kithsiri Janakantha Senanayake, L A, J Jayasooriya Arachchige, Sivaganesh, S, I Samaraweera, D, Thanusan, V, A E, K Musa, R M, H Balila, M A E, H Mohamed, Ali, H, H Zain Elabdin, Mahdi, S, Ahmed, H, S Abdoun Ishag Idris, Elsayed, M, Mahmoud, M, Boijsen, M, P-O, Lundgren, Gustafsson, U, Kiasat, A, Wogensen, F, Jurdell, E, Thorell, A, Thorarinsdottir, H, Utter, M, M Sundstrom, S, Wredberg, C, Kjellin, A, Nyberg, J, Frisk, B, Sund, M, Andersson, L, Gunnarsson, U, Cengiz, Y, Ahlqvist, S, Björklund, I, Royson, H, Weber, P, H-I, Pahlsson, Borin, E, Hjertberg, M, Schmid, R, Schivo, D, Despotidis, V, Breitenstein, S, F Staerkle, R, Schadde, E, Deichsel, F, Gerosa, A, Nocito, A, A Raptis, D, Mijuskovic, B, Zuber, M, Eisner, L, Kruspi, S, B Reinisch, K, Schoewe, C, Novak, A, F Palma, A, Teufelberger, G, Kimaro, M, King, R, A Zeynel, A Balkan, Gumar, M, M Ali Yavuz, Karabacak, U, Lap, G, B Ozkan, B, Karakahya, M, Adams, R, Morton, R, Henderson, L, Gratton, R, D Clement, K, K Yu-Ching Chang, Mcnish, D, Mcintosh, R, Milligan, W, Skelly, B, Anderson-Knight, H, Lawther, R, Onimowo, J, Shatkar, V, Tharmalingam, S, Woin, E, Fautz, T, Ziff, O, Dindyal, S, Talukder, S, Arman, S, Gadhvi, V, S Chew, L, Heath, J, Blencowe, N, Hallam, S, Gash, K, G Singh Mannu, D-C, Zachariades, C Snaith, A, S Hettiarachchi, T, Nesaratnam, A, Wheeler, J, Mccullagh, D, M Clements, J, Khan, A, Koumpa, F, Neophytou, C, Roth, J, C Soon, W, Deputy, M, Ahmed, A, Ashton, A, Vincent, J, Almy, J, Khan, T, J L, Y Allen, J Mcintyre, C, C Marshall, D, Sykes, M, Behar, N, Jordan, H, Rajjoub, Y, Sherman, T, White, T, Watts, A, Ardley, R, Arulampalam, T, Shah, A, Brown, D, Blower, E, Sutton, P, Gasteratos, K, Vimalachandran, D, Magee, C, Irwin, G, Mcguigan, A, Mcaleer, S, Morgan, C, Braungart, S, Lafferty, K, Labib, P, Tanase, A, Mangan, C, Reza, L, Woodward, H, Gouldthorpe, C, Turner, M, J R, L Wild, T A, M Malik, K Proctor, V, Hewage, K, Davies, J, Dubois, A, Sarwary, S, Zardab, A, Grant, A, Mcintyre, R, P Mogan, Y, W, Ho, F Hon Khi Chong, B, Tewari, S, Humm, G, Farinella, E, J Hall, N, J Wright, N, P Major, C, Xerri, T, P De Bono, Amin, J, Farhad, M, F Camilleri-Brennan, J, A G, N Robertson, Swann, J, Richards, J, Jabbar, A, Attard, M, Burns, H, Macdonald, E, Baldacchino, M, Skehan, J, Camilleri-Brennan, J, T Falconer Hall, Gimzewska, M, Mclachlan, G, Shah, J, Giles, J, Chiu, S, Weber, B, S Man Yeng Chiu, Highcock, S, Hassan, M, Beasley, W, Vlachogiorgos, A, Dias, S, Maharaj, G, Mcdonald, R, Macdonald, A, Witherspoon, P, Baird, A, Sarmah, P, Green, N, Youssef, H, Cross, K, M Rees, C, B Van Duren, Upchurch, E, Khan, K, Abudeeb, H, Hammad, A, Karandikar, S, Bowley, D, Karim, A, Chachulski, W, Richardson, L, Dawnay, G, Thompson, B, Mistry, A, Bhangu, A, Ghetia, M, Roy, S, Al-Obaedi, O, Das, K, Prabhudesai, A, M Cocker, D, J Tan, J, Tyler, R, F Di Franco, Ayyar, S, Vivekanantham, S, Gokani, S, Gillespie, M, Gudlaugsdottir, K, Pezas, T, Currow, C, M Young-Han Kim, Birring, A, Edwards, J, Das, S, Jha, M, Atkinson, K, Luck, J, Fozard, T, Puttick, M, Salama, Y, Shah, R, A Ibrahem, A, Ebdewi, H, Gravante, G, El-Rabaa, S, Nnajiuba, H, Allott, R, Bhargava, A, Chan, Z, Hassan, Z, Makinde, M, Hemingway, D, Dean, R, Boddy, A, Aber, A, Patel, V, Parakh, J, Parthiban, S, K Ubhi, H, S-P, Hosein, Ward, S, Malik, K, Jennings, L, Newton, T, Alkhouri, M, K Kang, M, Houlden, C, Barry, J, Raza, I, Farquharson, A, Bhattacharya, S, Chang, K, M S, J Wilson, N Neo, Y, Ibrahim, I, Chan, E, S Peck, F, J Lim, P, S North, A, Blundell, R, Williamson, A, Fouad, D, Minocha, A, Mccarthy, K, Court, E, Chambers, A, Yee, J, C Tham, J, Beaton, C, Walsh, U, Lockey, J, Bokhari, S, Howells, L, Griffiths, M, Yallop, L, Singh, S, Nasher, O, Jackson, P, M Shariffuddin, A, C Ho, W, Pabla, G, Ramzi, S, Zeidan, S, Doughty, J, Sinha, S, Davenport, R, Lewis, J, Duffy, L, Mcaleer, E, Williams, E, Som, R, Javed, O, Boal, M, Harrison, N, Tafazal, H, Brogden, T, Griffiths, E, D Obute, R, E Glover, T, J Clark, D, Boshnaq, M, Akhtar, M, Capleton, P, Doughan, S, Rabie, M, Mohamed, I, Samuel, D, Dickson, L, Kennedy, M, Dempster, E, Brown, E, Maple, N, Monaghan, E, Wolf, B, Garland, A, Mcphee, A, Anderson, D, Anderson, R, Hassan, S, Smith, D, Lund, J, Boereboom, C, Murphy, J, Tierney, G, Tou, S, F Zimmermann, E, J Smart, N, M Warwick, A, Stasinou, T, Daniels, I, Findlay-Cooper, K, Mitrasinovic, S, Ray, S, Varcada, M, R D, S Omara, Spurr, M, Parkinson, L, Hanks, A, J, Ma, Abington, E, Ramcharn, M, Williams, G, Winstanley, J, D Kennedy, E, E N, W Yeung, Fergusson, S, Jones, C, O'Neill, S, J Lim, S, Liew, I, Nair, H, Fairfield, C, Koh, S, Wilson, A, Anandkumar, D, Kirupagaran, A, F Jones, T, D Torrance, H, J Fowler, A, Chandrakumar, C, Patel, P, F Ashraf, S, M Lakhani, S, L Mclean, A, Basson, S, Batt, J, Bowman, C, Stoddart, M, Benons, N, Mason, C, Harrison, R, Quayle, J, Barker, T, Summerour, V, Harper, E, Smith, C, Hampton, M, K Pitt, S, E Ward, A, O'Connor, T, G Heywood, E, M Drake, T, Chowdhury, A, Hossaini, S, F Watson, N, Mckechnie, D, Farah, A, Chun, A, Koh, H, Lim, G, Sunderland, G, Gould, L, C Munipalle, P, Rooney, H, D R, L Browning, Pereira, B, Nemeth, K, Decker, E, Giuliani, S, Shalaby, A, Shaikh, S, Y Tan, C, E Y, A Palkhi, Kostov, E, Harbord, P, Barnacle, J, Szczap, A, Chidambaram, S, Y Chen, C, Kulasabanathan, K, Chhabra, S, M Palliyil, M, Zikry, M, Porter, J, Raslan, C, Hafiz, S, Soltani, N, Baillie, K, Marples, L, Macfarlane, A, Thurairaja, R, Singh, P, Sheth, S, Patel, K, Khalili, M, Choi, J, Benger, M, Boyce, T, Whewell, H, Jones, E, Th'Ng, F, Robertson, N, Mirza, A, Saeed, H, Galloway, S, Elena, G, Afzal, M, Zakir, M, Sodde, P, Hand, C, Sriram, A, Clark, T, Holton, P, Livesey, A, Sinha, Y, M Iqbal, F, S Bharj, I, Rotundo, A, Jenvey, C, Slade, R, Golding, D, Haines, S, A Ne'ma Abdullah, A, W Tilston, T, Loughran, D, Donoghue, D, Giacci, L, M Ashur Sherif, Harrison, P, Tang, A, Kotecha, D, Elshaer, M, Urbonas, T, Riaz, A, Chapman, A, Acharya, P, Shalhoub, J, Grossart, C, Mcmorran, D, Mlotshwa, M, Hawkins, W, Loizides, S, Krishna, K, Orchard, M, W Ho, C, Thomson, P, Khan, S, Taylor, F, Shukla, J, E Howie, E, Macdonald, L, Komolafe, O, Mcintyre, N, Cragg, J, Parker, J, Stewart, D, L, L, Tracy, J, Farooq, T, Molina, G, Kaafarani, H, Luque, L, Beyene, R, Sava, J, Scott, M, Swaroop, M, Kennedy, R, A Azodo, I, Heffernan, D, Chun, T, Stephen, A, Sion, M, S Weinstein, M, Punja, V, Bugaev, N, Goodstein, M, Razmdjou, S, Etchill, E, C Puyana, J, Kesinger, M, Napolitano, L, K, To, Hemmila, M, Todd, O, Jenner, E, Hoogakker, E, Roi, D, H Chieh Chen, J, Ismail, L, and G Escobar, E

Subjects
Adult, Male, Gastrointestinal Diseases, mortality, global surgery, abdominal, emergency, LMIC, surgery, Developed Countries, Checklist, Cohort Studies, Health Care, Abdomen, Humans, Female, Patient Safety, Emergencies, Quality Assurance, Developing Countries, Digestive System Surgical Procedures, Quality Assurance, Health Care
Published
2016

128. Inflammatory bowel disease patients requiring surgery can be treated in referral centres regardless of the COVID-19 status of the hospital: results of a multicentric European study during the first COVID-19 outbreak (COVID-Surg)

Author

Rottoli, Matteo, Pellino, Gianluca, Tanzanu, Marta, Baldi, Caterina, Frontali, Alice, Carvello, Michele, Foppa, Caterina, Kontovounisios, Christos, Tekkis, Paris, Colombo, Francesco, Sancho-Muriel, Jorge, Frasson, Matteo, Danelli, Piergiorgio, Celentano, Valerio, Spinelli, Antonino, Panis, Yves, Sampietro, Gianluca M., and Poggioli, Gilberto

Abstract

Outcomes of inflammatory bowel disease (IBD) patients requiring surgery during the outbreak of Coronavirus disease 19 (COVID-19) are unknown. Aim of this study was to analyse the outcomes depending on the COVID-19 status of the centre. Patients undergoing surgery in six COVID-19 treatment and one COVID-free hospitals (five countries) during the first COVID-19 peak were included. Variables associated with risk of moderate-to-severe complications were identified using logistic regression analysis. A total of 91 patients with Crohn’s disease (54, 59.3%) or ulcerative colitis (37, 40.7%), 66 (72.5%) had surgery in one of the COVID-19-treatment hospitals, while 25 (27.5%) in the COVID-19-free centre. More COVID-19-treatment patients required urgent surgery (48.4% vs. 24%, p= 0.035), did not discontinue biologic therapy (15.1% vs. 0%, p= 0.039), underwent surgery without a SARS-CoV-2 test (19.7% vs. 0%, p= 0.0033), and required intensive care admission (10.6% vs. 0%, p= 0.032). Three patients (4.6%) had a SARS-CoV-2 infection postoperatively. Postoperative complications were associated with the use of steroids at surgery (Odds ratio [OR] = 4.10, 95% CI 1.14–15.3, p= 0.03), presence of comorbidities (OR = 3.33, 95% CI 1.08–11, p= 0.035), and Crohn’s disease (vs. ulcerative colitis, OR = 3.82, 95% CI 1.14–15.4, p= 0.028). IBD patients can undergo surgery regardless of the COVID-19 status of the referral centre. The risk of SARS-CoV-2 infection should be taken into account.

Published
2021
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129. Efficacy of Tumour Necrosis Factor-alpha therapy in paediatric Crohn’s disease patients with perianal lesions: a systematic review

Author

Carnovale, Carla, Maffioli, Anna, Zaffaroni, Gloria, Mazhar, Faizan, Battini, Vera, Mosini, Giulia, Pozzi, Marco, Radice, Sonia, Clementi, Emilio, and Danelli, Piergiorgio

Abstract

ABSTRACTIntroduction: Anti-Tumor Necrosis Factor-alpha (TNF-α) therapy, primarily infliximab and adalimumab, are now increasingly used to induce and maintain disease remission in the pediatric perianal Crohn’s disease (CD) population, however, their optimal use has not yet been defined in the pediatric setting.Areas covered: In accordance with a published protocol (PROSPERO no. CRD42019118838), we systematically and critically evaluated all published evidence on the efficacy and safety of anti-TNF-α in children with perianal CD, in the PubMed, MEDLINE, Embase, Cochrane and clinicalTrials.gov databases until October, 18th, 2018. We included in our systematic review 29 articles yielding a total of 565 perianal CD patients aged between 9 months to 18 years.Expert opinion: According to low-quality evidence from small, uncontrolled and heterogeneous descriptive studies, and very few randomized controlled trial, nearly three-fifths children with perianal CD achieved remission with anti-TNF-α treatment and in approximately 40% remission was maintained after 12 months, with practically low discontinuation rate due to serious adverse events. More than half of the patients achieved complete fistula closure. There is still a need for more robust evidence adequately assessing the efficacy and safety of anti-TNF-α therapy in pediatric perianal CD, as well as in comparison with other therapies.

Published
2020
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130. Mast cell chymase protects against acute ischemic kidney injury by limiting neutrophil hyperactivation and recruitment

Author

Madjene, Lydia Celia, Danelli, Luca, Dahdah, Albert, Vibhushan, Shamila, Bex-Coudrat, Julie, Pacreau, Emeline, Vaugier, Celine, Claver, Julien, Rolas, Loïc, Pons, Maguelonne, Madera-Salcedo, Iris Karina, Beghdadi, Walid, El Ghoneimi, Alaa, Benhamou, Marc, Launay, Pierre, Abrink, Magnus, Pejler, Gunnar, Moura, Ivan Cruz, Charles, Nicolas, Daugas, Eric, Perianin, Axel, and Blank, Ulrich

Abstract

Here we investigated the role of murine mast cell protease 4 (MCPT4), the functional counterpart of human mast cell chymase, in an experimental model of renal ischemia reperfusion injury, a major cause of acute kidney injury. MCPT4-deficient mice had worsened kidney function compared to wildtype mice. MCPT4 absence exacerbated pathologic neutrophil infiltration in the kidney and increased kidney myeloperoxidase expression, cell death and necrosis. In kidneys with ischemia reperfusion injury, when compared to wildtype mice, MCPT4-deficient mice showed increased surface expression of adhesion molecules necessary for leukocyte extravasation including neutrophil CD162 and endothelial cell CD54. In vitro, human chymase mediated the cleavage of neutrophil expressed CD162 and also CD54, P- and E-Selectin expressed on human glomerular endothelial cells. MCPT4 also dampened systemic neutrophil activation after renal ischemia reperfusion injury as neutrophils expressed more CD11b integrin and produced more reactive oxygen species in MCPT4-deficient mice. Accordingly, after renal injury, neutrophil migration to an inflammatory site distal from the kidney was increased in MCPT4-deficient versus wildtype mice. Thus, contrary to the described overall aggravating role of mast cells, one granule-released mediator, the MCPT4 chymase, exhibits a potent anti-inflammatory function in renal ischemia reperfusion injury by controlling neutrophil extravasation and activation thereby limiting associated damage.

Published
2020
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133. Estrutura e distribuição espacial de populações de palmeiras em diferentes altitudes na Serra do Mar, Ubatuba, São Paulo, Brasil

Author

Kelly Fernandes de Oliveira, Simey Thury Vieira Fisch, Juliana de Souza Duarte, Matheus Fischer Danelli, Luiz Fernando da Silva Martins, and Carlos Alfredo Joly

Subjects
Arecaceae, Mata Atlântica, Padrão espacial, Biology (General), QH301-705.5, Botany, QK1-989
Abstract

A estrutura ontogenética e espacial de dez espécies de palmeiras que ocorrem na Serra do Mar, Ubatuba, São Paulo, foi analisada nas fitofisionomias: Floresta Ombrófila Densa de Terras Baixas, Submontana e Montana. Em 12 parcelas de um hectare (quatro parcelas em cada fitofisionomia) foram instaladas três transecções de 10 × 100 m, subdivididas em subparcelas de 10 × 10 m, totalizando 0,3 hectares inventariados em cada parcela. Foram procedidas identificação e biometria completa de todas as palmeiras, e a distribuição espacial das populações foi analisada por meio do Índice de agregação (Ia) proposto por Perry. Com a elevação, foram observadas alterações na riqueza e abundância das espécies, com predominância de plântulas em Astrocaryum aculeatissimum, Euterpe edulis, Geonoma gamiova, Geonoma pohliana e Syagrus pseudococos. Indivíduos jovens apresentaram maior frequência em Attalea dubia, Bactris hatschbachii e Geonoma schottiana. Geonoma elegans apresentou mais adultos e Bactris setosa, frequências similares de plântulas e jovens. A maioria dos estádios ontogenéticos não foi correlacionada com a altitude e o padrão agregado foi predominante nas espécies de palmeiras. Dessa forma, concluiu-se que a altitude não influenciou no padrão de distribuição espacial das populações de palmeiras, mas afetou a composição dessa comunidade na Floresta Ombrófila Densa na Serra do Mar.

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134. Evaluation of the functionality of bread loaves prepared with quinoa flakes through biological tests

Author

Márcia Flach Gewehr, Carlos Henrique Pagno, Daiane Danelli, Lívia Marchi de Melo, Simone Hickmann Flôres, and Erna Vogt de Jong

Subjects
Quinoa flakes/nutritional evaluation, Quinoa flakes/beneficial effects, Composition, Bread/processing/effects, Bread/ nutritional evaluation, Tocopherols, Pharmacy and materia medica, RS1-441
Abstract

ABSTRACT The aim of this study was to evaluate quinoa flakes and bread prepared with the pseudocereal with regard to nutritional aspects by determining chemical composition, content of tocopherols and fatty acid composition as well as to possible beneficial effects in Wistar rats given commercial feed supplemented or not with quinoa flakes and cholesterol. The following parameters were determined: weight gain, food intake, liver weight, fat in liver and lipid profile in blood and liver. The results showed that processing affected the nutritional characteristics of bread because there was a significant increase in dietary fiber content but reduction in soluble fiber. Increased fiber did not influence food intake or weight gain. Regarding fat in liver of rats, the group that consumed bread without quinoa but with cholesterol showed higher lipid content. The addition of quinoa increased significantly the level of all types of tocopherols, especially in the group of animals that consumed 20% quinoa bread, improving the lipid profile both in blood and liver, largely due to a reduction in oxidized LDL.

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135. Leiomyomatosis peritonealis disseminata: A case report of recurrent presentation and literature review.

Author

Ferrario, Luca, Zerbi, Pietro, Angiolini, Maria Rachele, Agarossi, Alberto, Riggio, Eliana, Bondurri, Andrea, and Danelli, Piergiorgio

Abstract

Introduction Leiomyomatosis peritonealis disseminata (LPD) is an uncommon disease featured by the presence of multiple nodules of smooth muscle cells scattered in the abdominal cavity. To date only about 150 cases have been reported in literature. We report a case of recurrent LPD after laparotomy. Case presentation In March 2016 a 36-year-old female, with a history of multiple previous laparoscopic myomectomies, consulted her gynaecologist complaining abdominal pain; a MRI was performed and reported multiple pelvic masses, subsequently excised during laparotomy. The patient refused a total hysterectomy with bilateral salpingo-oopherectomy so a close follow-up was recommended. In November 2017 when a new MRI revealed recurrency of the disease, a second laparotomy is performed and all visible nodules are excised. The histological exam confirms LPD diagnosis. On follow-up after three months the patients is completely asymptomatic. Discussion Differential diagnosis of LPD is challenging due to its similarity to carcinomatosis and to other benign abdominal disorders. Malignant transformation is rare, but it may occur, so a close follow-up is necessary. Even if there is no consensus regarding the treatment, hormonal therapy is probably the best first line approach, while surgery should be the second choice. Conclusions LPD is an uncommon but potentially severe disease. In our opinion larger studies are necessary to improve our diagnostic effectiveness and to define the best therapeutic strategy. [ABSTRACT FROM AUTHOR]

Published
2018
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136. Frontline Science: Mast cells regulate neutrophil homeostasis by influencing macrophage clearance activity

Author

Jachetti, Elena, D'Incà, Federica, Danelli, Luca, Magris, Raffaella, Dal Secco, Chiara, Vit, Filippo, Cancila, Valeria, Tripodo, Claudio, Scapini, Patrizia, Colombo, Mario Paolo, Pucillo, Carlo, and Frossi, Barbara

Abstract

The receptor tyrosine kinase cKit and its ligand stem cell factor are essential for mast cells (MC) development and survival. Strains with mutations affecting the Kitgene display a profound MC deficiency in all tissues and have been extensively used to investigate the role of MC in both physiologic and pathologic conditions. However, these mice present a variety of abnormalities in other immune cell populations that can affect the interpretation of MC‐related responses. C57BL/6 KitW‐share characterized by an aberrant extramedullary myelopoiesis and systemic neutrophilia. MC deficiency in KitW‐shmice can be selectively repaired by engraftment with in vitro‐differentiated MC to validate MC‐specific functions. Nevertheless, the impact of MC reconstitution on other immune populations has never been evaluated in detail. Here, we specifically investigated the neutrophil compartment in primary and secondary lymphoid organs of C57BL/6 KitW‐shmice before and after MC reconstitution. We found that, albeit not apparently affecting neutrophils phenotype or maturation, MC reconstitution of KitW‐shmice restored the number of neutrophils at a level similar to that of wild‐type C57BL/6 mice. In vitro and ex vivoexperiments indicated that MC can influence neutrophil clearance by increasing macrophages’ phagocytic activity. Furthermore, the G‐CSF/IL‐17 axis was also influenced by the presence or absence of MC in KitW‐shmice. These data suggest that MC play a role in the control of neutrophil homeostasis and that this aspect should be taken into account in the interpretation of results obtained using KitW‐shmice. Mast cell reconstitution of Kit(W‐sh)/Kit(W‐sh) sash mice attenuates neutrophilia by reduction of systemic levels of G‐CSF and IL‐17, and by enhancement of the macrophage‐mediated neutrophil phagocytosis.

Published
2019
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137. MHC class II cell-autonomously regulates self-renewal and differentiation of normal and malignant B cells

Author

Merkenschlager, Julia, Eksmond, Urszula, Danelli, Luca, Attig, Jan, Young, George R., Nowosad, Carla, Tolar, Pavel, and Kassiotis, George

Abstract

Best known for presenting antigenic peptides to CD4+T cells, major histocompatibility complex class II (MHC II) also transmits or may modify intracellular signals. Here, we show that MHC II cell-autonomously regulates the balance between self-renewal and differentiation in B-cell precursors, as well as in malignant B cells. Initiation of MHC II expression early during bone marrow B-cell development limited the occupancy of cycling compartments by promoting differentiation, thus regulating the numerical output of B cells. MHC II deficiency preserved stem cell characteristics in developing pro-B cells in vivo, and ectopic MHC II expression accelerated hematopoietic stem cell differentiation in vitro. Moreover, MHC II expression restrained growth of murine B-cell leukemia cell lines in vitro and in vivo, independently of CD4+T-cell surveillance. Our results highlight an important cell-intrinsic contribution of MHC II expression to establishing the differentiated B-cell phenotype.

Published
2019
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138. Caractérisation de la machinerie de transport régulant la dégranulation mastocytaire.

Author

Munoz, I., Danelli, L., Kurowska, M., Blank, U., and Ménasché, G.

Abstract

Résumé Les mastocytes sont des cellules granuleuses préférentiellement localisées au niveau des tissus dont les précurseurs hématopoïétiques sont retrouvés au niveau de la moelle osseuse. Leurs cytoplasmes renferment de très nombreuses granulations contenant des médiateurs préformés. À leurs surfaces, les mastocytes expriment de nombreux récepteurs incluant le récepteur de haute affinité pour les IgE (RFcɛI). Son agrégation par le complexe IgE–allergène entraîne une rapide libération du contenu des granules de sécrétion ce qui déclenche la phase immédiate de l’hypersensibilité de type I. La machinerie de sécrétion utilisée par les granules de sécrétion du mastocyte suite à son activation et notamment son interaction avec le cytosquelette reste mal connue. Nous nous sommes particulièrement intéressés au rôle que pourrait jouer la protéine motrice kinésine-1 dans le transport sur le réseau de microtubule des granules contenant les médiateurs vers leur lieu de sécrétion. L’intervention du complexe protéique formé de la petite GTPase Rab27b et de son effecteur synaptotagmin-like protein 3 (Slp3) est responsable du recrutement de la kinésine-1 sur les granules de sécrétions suite à l’activation du mastocyte par RFcɛI. La formation du complexe Rab27b/Slp3/kinésine-1 s’est avéré dépendre de l’activité phosphoinositol 3-kinase (PI3K). Nous proposons ici une brève synthèse des connaissances nouvelles sur la caractérisation de la machinerie de transport régulant la dégranulation mastocytaire. Mast cells (MC) are granulated cells of hematopoietic origin localised to most tissues whose haematopoietic precursors are found in bone marrow. Their cytoplasm holds large numbers of granulations containing preformed mediators. MC express at their surface numerous receptors including the high-affinity IgE receptor (FcɛRI). Cross-linking of receptor-bound IgE by specific multivalent antigens triggers the release within minutes of preformed mediators contained in secretory granules (SGs), leading to immediate IgE-mediated type I hypersensitivity reaction. The secretory machinery that allows SG secretion by mast cells and its interaction with the cytoskeleton continue to be a poorly understood. We are particularly interested in analysing the role of kinesin-1 motor protein, a conventional member of the kinesin superfamily, in the transport of SG along the microtubule network to their site of secretion. The protein complex formed by the small GTPase Rab27b and its effector, synaptotagmin-like protein 3 (Slp3), is responsible for the stimulation-dependent recruitment of kinesin-1 to SG upon FcɛRI activation. Formation of the Rab27b/Slp3/kinesine-1 complex is dependent on phosphatidylinositol 3-kinase (PI3K) activity. Herein, we propose a brief overview of recent knowledge acquired regarding characterisation of the transport machinery regulating mast cell degranulation. [ABSTRACT FROM AUTHOR]

Published
2017
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139. [Surgical options in the treatment of perianal Crohn's disease]

Author

Danelli P, Bartolucci C, Gianluca Matteo Sampietro, Panizzo V, Sartani A, Maconi G, Parente E, and Am, Taschieri

Subjects
Adult, Male, Anus Diseases, Adolescent, Crohn Disease, Humans, Female, Middle Aged
Abstract

About 40% of patients with Crohns disease (CD) have a perianal involvement. Despite the recent introduction of anti-TNF antibody, this therapy has uncertain long-term results and surgery still remains a major treatment option.This study relates our experience in surgical management of perianal CD without anti-TNF treatment. From July 92 to February 02, 37 patients with perianal Crohns disease were treated, 43 underwent local operations or faecal diversion for fistulas and/or abscesses. Patients not requiring surgery or in therapy with anti-TNF. were excluded from the study. We analysed the outcome of surgical treatment for perianal CD.Male to female ratio was 1:0.6, median age was 36,9 years (range 17-62). Perianal disease included 32 fistulas (16 trans-sphincteric, 2 superficial, 2 ano-vaginal, 10 multiple and complex, 2 horseshoe) and 7 abscesses (5 perianal, 2 ischio-rectal). Local surgery included 1 abscess drainage, 5 abscess drainage and fistula incision with seton insertion, 2 fistulotomy, 9 partial fistulectomy and seton insertion. At surgery, 40% of patients were ongoing a medical treatment with 5-ASA and/or antibiotics, 40% with steroids and/or immunosoppressors, 15% only with 5-ASA and 5% no ongoing treatment. The horseshoe fistulas were managed with a fistulotomy and seton insertion. One patient with ano-vaginal fistula required proctectomy and the other one total proctocolectomy. Patients treated by diverting colonostomy (3) had fistula recurrence after its closure in 100%. 20% of patients required total proctocolectomy and ileostomy for extensive intestinal disease. Of the 27 patients undergoing seton insertion or fistulotomy none had faecal incontinence due to the operation and 38% had a 1 year recurrence.Perianal CD is a heterogeneous entity, therefore its management is still controversial. Moreover, a high percentage of patients (18% in our series) requires a major surgery due to the extension and seriousness of rectal involvement. In our survey only 12 patients (39%), with trans-sphincteric fistula, could have been theoretically treated with anti-TNF. We wonder if the cost-and-benefit of this medical treatment justifies its application on patients that could undergo a surgical treatment with good long-term results.

Published
2004

140. [Strictureplasty in the surgical treatment of complicated Crohn's disease]

Author

Gianluca Matteo Sampietro, Sartani A, Danelli P, Ghizzoni M, Sposito C, Maconi G, Parente E, and Am, Taschieri

Subjects
Adult, Male, Crohn Disease, Humans, Female, Prospective Studies, Digestive System Surgical Procedures
Abstract

Crohns disease is a panintestinal chronic inflammatory condition. Its remitting-relapsing behaviour may require in the single patient repeated surgeries, with the aim of resolving the complications of the disease. The awereness that surgery cannot resolve the disease has led, in the last years, to the development of new "conservative surgical techniques", which preserve as much of the intestinal tissue as possible. These techniques are minimal resection and strictureplasty (SP). Aim of the study was to perform a prospective analysis of the long-term outcome of SP in a consecutive series of patients undergoing surgery for complicated Crohns Disease at the Division of general surgery, L. Sacco University Hospital, Milano, Italia.During the period of October 1992 to June 2002, 286 patients underwent surgical procedures for jejunoileal Crohns disease. 116 of them underwent SP resulting in a total of 217 procedures, of which: 111 Heineke-Mikulicz SP (51.2%), 36 ileoileal side-to-side SP (16.6%), 40 ileoceacal SP (18.4%) and the remaining 30 ileocolic SP (13.8%), as previously described by A.M. Taschieri. Fiftyone of the patients (23.5%) had concomitantly a minimal bowel resection. Postoperative mortality was nil, while in 3 cases (2.59%) repeated surgery was necessary due to postsurgical complications. Time-to-event estimates were performed using the Kaplan-Meier function.mortality, morbidity, and long-term results in this population of patients who underwent SP are encouraging and in line with reports in the international literature. It is suggested that SP together with minimal bowel resections, may be considered as first line surgical therapy in patients with Crohns Disease.

Published
2004

142. How many deficits in the same dyslexic brains? A behavioural and fMRI assessment of comorbidity in adult dyslexics

Author

Danelli, Laura, Berlingeri, Manuela, Bottini, Gabriella, Borghese, Nunzio A., Lucchese, Mirko, Sberna, Maurizio, Price, Cathy J., and Paulesu, Eraldo

Abstract

Dyslexia can have different manifestations: this has motivated different theories on its nature, on its underlying brain bases and enduring controversies on how to best treat it. The relative weight of the different manifestations has never been evaluated using both behavioural and fMRI measures, a challenge taken here to assess the major systems called into play in dyslexia by different theories.

Published
2017
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144. P.06.21 IMMUNOHISTOCHEMICAL EXPRESSION OF THE RECEPTOR FOR THE ADVANCED GLYCATION END PRODUCTS (RAGE) IN THE INTESTINAL MUCOSA OF PATIENTS WITH CROHN'S DISEASE (CD)

Author

Ciccocioppo, R., primary, Boccaccio, V., additional, Imbesi, V., additional, Russo, M.L., additional, Betti, E., additional, Gallia, A., additional, Racca, F., additional, Vanoli, A., additional, Manca, R., additional, Ardizzone, S., additional, Fociani, P., additional, Danelli, P., additional, and Corazza, G.R., additional

Published
2012
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