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105. Donor Club Cell Secretory Protein G38A Polymorphism Is Associated With a Decreased Risk of Primary Graft Dysfunction in the French Cohort in Lung Transplantation

Author

Hin, A., Kannengiesser, C., Roussel, A., Renaud-Picard, B., Roux, A., Reynaud-Gaubert, M., Claustre, J., Tissot, A., Guillemain, R., Mornex, Jean-François, Mussot, S., Dromer, C., Dahan, M., Brugiere, O., Mercier, O., Borie, R., Pretolani, M., Castier, Y., Mordant, P., Consortium, COLT, Infections Virales et Pathologie Comparée - UMR 754 (IVPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), and Vaincre la Mucoviscidose

Subjects
Male, Adult, medicine.medical_specialty, medicine.medical_treatment, [SDV]Life Sciences [q-bio], Primary Graft Dysfunction, 030230 surgery, Gastroenterology, Polymorphism, Single Nucleotide, Tissue Donors, 03 medical and health sciences, 0302 clinical medicine, Interquartile range, Risk Factors, Internal medicine, Medicine, Lung transplantation, Uteroglobin, Humans, Prospective Studies, Prospective cohort study, Retrospective Studies, Primary Graft Dysfunction/*genetics, Transplantation, Lung, Uteroglobin/*genetics, business.industry, Retrospective cohort study, Odds ratio, Single Nucleotide, respiratory system, Middle Aged, medicine.anatomical_structure, Treatment Outcome, 030228 respiratory system, Reperfusion Injury, Cohort, Multivariate Analysis, Female, Gene-Environment Interaction, France, business, Polymorphism, Lung Transplantation, Lung Transplantation/*methods
Abstract

BACKGROUND: Club Cell Secretory Protein (CCSP) G38A polymorphism has recently been involved in lung epithelial susceptibility to external injuries. Lung transplantation (LT) is currently limited by ischemia-reperfusion injury leading to primary graft dysfunction (PGD). We thus hypothesized that donor CCSP G38A polymorphism might impact the risk of PGD after LT. METHODS: We focused on LT included in the French multicentric Cohort in Lung Transplantation (COLT), performed between January 2009 and December 2014, and associated with preoperative blood samples from the donor and the recipient. Characteristics of the donors, recipients, procedures, early and late outcomes were prospectively recorded in COLT. The CCSP serum concentration and CCSP gene G38A polymorphism were retrospectively determined in a blind manner. Their association with grade 3 PGD was studied in univariate and multivariate analysis. RESULTS: The study group included 104 LT donors and recipients, 84 with grade 0 to 2 PGD and 20 with grade 3 PGD. Preoperative CCSP serum concentration was significantly higher in the donors (median, 22.54 ng/mL; interquartile range, 9.6-43.9) than in the recipients (median, 7.03 ng/mL; interquartile range, 0.89-19.2; P \\textless 0.001) but none impacted the risk of grade 3 PGD (P = 0.93 and P = 0.69, respectively). Donor CCSP G38A polymorphism was associated with a decreased risk of grade 3 PGD in univariate (AG + AA 3/21 = 14.2% vs GG 10/26 = 38.4%, P = 0.044) and multivariate analysis (odds ratio associated with AG + AA, 0.22; 95% confidence interval, 0.041-0.88; P = 0.045), but recipient CCSP G38A polymorphism was not. CONCLUSIONS: Donor CCSP G38A polymorphism is associated with a decreased risk of severe PGD after LT in the COLT study. These findings should be confirmed in the frame of a prospective study.

Published
2018
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106. COLT: Ten years of research in lung transplantation, results and perspectives

Author

Tissot, A., Foureau, A., Brosseau, C., Danger, R., Roux, A., Bernasconi, E., Gomez, C., Durand, M., Picard, B. R., Le Pavec, J., Claustre, J., Lacoste, P., Benmerad, M., Pain, M., Siroux, V., Royer, P. -J., Mordant, P., Reynaud-Gaubert, M., Kessler, R., Brugiere, O., Mornex, J. -F, Dromer, C., Dahan, M., Knoop, C., Boussaud, V., Koutsokera, A., Botturi-Cavailles, K., Durand, E., Loy, J., Nicod, L., Pison, C., Brouard, S., Blanc, F. -X., Magnan, A., Colt, Consortium, Immunoregulation And Immunointervention in Transplantation and Autoimmunity (Team 4 - U1064 Inserm - CRTI), Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Laboratoire d'étude des marériaux, Université de Brest (UBO), Service de pneumologie [Hôpital Foch], Hôpital Foch [Suresnes], CIC Bordeaux, Université Bordeaux Segalen - Bordeaux 2-Institut National de la Santé et de la Recherche Médicale (INSERM), Service de Pneumologie et Réanimation, Centre de reference de l'hypertension artérielle pulmonaire, Hôpital Antoine Béclère, Assistance Publique - Hôpitaux de Paris (AP-HP), Université Paris Sud (Paris 11), Dr SPOC, Paris, Center for Public Health Research (CSISP), University of Valencia, Microbes évolution phylogénie et infections (MEPHI), Institut de Recherche pour le Développement (IRD)-Aix Marseille Université (AMU)-Centre National de la Recherche Scientifique (CNRS), Service de Pneumologie, Nouvel Hôpital Civil Strasbourg, CHU Bordeaux [Bordeaux], Ecole Nationale Supérieure de Chimie de Rennes (ENSCR), Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Intervention, innovation, imagerie, ingénierie en santé - UFC (I4S), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), Laboratory of Fundamental and Applied Bioenergetics = Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes [2016-2019] (UGA [2016-2019]), Unité de recherche de l'institut du thorax (ITX-lab), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), ANR-17-CE17-0008,Biket,Cellules B GZMB+, un facteur clé de l'immunité chez l'homme?(2017), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de transplantation pulmonaire [Hôpital Foch, Suresnes] (Pneumologie), Hôpital Foch [Suresnes]-Centre de fibrose kystique adulte [Hôpital Foch, Suresnes], Laboratoire d'étude des Interactions Sol - Agrosystème - Hydrosystème (UMR LISAH), Institut de Recherche pour le Développement (IRD)-Institut National de la Recherche Agronomique (INRA)-Centre international d'études supérieures en sciences agronomiques (Montpellier SupAgro)-Institut de Recherche pour le Développement (IRD [ Madagascar])-Institut national d’études supérieures agronomiques de Montpellier (Montpellier SupAgro), Ecole Nationale Supérieure de Chimie de Rennes, Neuro-Psycho Pharmacologie des Systèmes Dopimanégiques sous-corticaux - Clermont Auvergne (NPsy-Sydo), CHU Clermont-Ferrand-Université Clermont Auvergne (UCA), Université Clermont Auvergne (UCA), Laboratoire de bioénergétique fondamentale et appliquée (LBFA), Université Grenoble Alpes (UGA)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Joseph Fourier - Grenoble 1 (UJF), and Université Joseph Fourier - Grenoble 1 (UJF)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Grenoble Alpes (UGA)

Subjects
Cohort Studies, Biomedical Research, Postoperative Complications, [SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases, Chronic Disease, Graft Survival, Humans, History, 20th Century, Primary Graft Dysfunction, History, 21st Century, ComputingMilieux_MISCELLANEOUS, Lung Transplantation
Abstract

National audience

Published
2018
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109. Quelle classification prédit le mieux le risque de cancer sous-muqueux et intra-muqueux avec des endoscopes HD sans zoom? Etude prospective sur 200 dissections colorectales

Author

Jacques, J, additional, Lepetit, H, additional, Fabritius, M, additional, Legros, R, additional, Dahan, M, additional, Albouys, J, additional, Valgueblasse, V, additional, Sautereau, D, additional, Rivory, J, additional, Ponchon, T, additional, and Pioche, M, additional

Published
2019
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110. La classification de Paris est-elle fiable pour évaluer les lésions dégénérées sur endobrachyoesophage? Résultats d'une étude du GRAPHE incluant 29 endoscopistes chevronnés

Author

Chapelle, N, additional, Branche, J, additional, Chabrun, E, additional, Karsenti, D, additional, Chaput, U, additional, Caillol, F, additional, Koch, S, additional, Vanbiervliet, G, additional, Dahan, M, additional, Quénéhervé, L, additional, Musquer, N, additional, Robaszkiewicz, M, additional, and Coron, E, additional

Published
2019
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113. Blood gene expression predicts bronchiolitis obliterans syndrome appearance after lung transplantation

Author

Danger, Richard, Royer, Pierre J., Reboulleau, D., Loy, J., Tissot, A., Lacoste, P., Roux, A., Reynaud-Gaubert, M., Kessler, R., Mussot, S., Dromer, C., Brugiere, O., Mornex, J., Guillemain, R., Dahan, M., Knoop, C., Botturi, K., Pison, C., Nicod, L., Brouard, S., Magnan, Antoine, SysCLAD, ., Institut National de la Santé et de la Recherche Médicale (INSERM), Centre hospitalier universitaire de Nantes (CHU Nantes), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Aix Marseille Université (AMU), Centre Hospitalier Universitaire de Strasbourg (CHU de Strasbourg ), Service de Chirurgie Thoracique, Vasculaire et Transplantation Cardiopulmonaire, Hôpital Marie Lannelongue, CHU Bordeaux [Bordeaux], Service Pneumologie et Transplantation Pulmonaire, Hôpital Foch [Suresnes], Infections Virales et Pathologie Comparée - UMR 754 (IVPC), Institut National de la Recherche Agronomique (INRA)-École pratique des hautes études (EPHE), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon, Hôpital Européen Georges Pompidou [APHP] (HEGP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest (HUPO), CHU Toulouse [Toulouse], Hôpital Erasme [Bruxelles] (ULB), Faculté de Médecine [Bruxelles] (ULB), Université libre de Bruxelles (ULB)-Université libre de Bruxelles (ULB), Clinique Universitaire de Pneumologie, Pôle Thorax et Vaisseaux, Centre Hospitalier Universitaire de Grenoble, Centre Hospitalier Universitaire Vaudois (CHUV), Systems prediction of Chronic Lung Allograft Dysfunction, Partenaires INRAE, Unité de recherche de l'institut du thorax (ITX-lab), Hôpital Marie-Lannelongue, Institut National de la Recherche Agronomique (INRA)-École Pratique des Hautes Études (EPHE), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), and Centre Hospitalier Universitaire [Grenoble] (CHU)

Subjects
gene expression, graft survival, lung transplantation, [SDV.MHEP.PSR]Life Sciences [q-bio]/Human health and pathology/Pulmonology and respiratory tract, ComputingMilieux_MISCELLANEOUS
Abstract

Volume: 17 Supplement: 3 Special Issue: SI; International audience

Published
2017

114. Blood Gene Expression Predicts Bronchiolitis Obliterans Syndrome Appearance After Lung Transplantation

Author

Danger, R., Royer, Pierre-Joseph, Reboulleau, D., Loy, J., Tissot, A., Lacoste, P., Roux, A., Reynaud-Gaubert, M., Kessler, R., Mussot, S., Dromer, C., BrugiSre, O., Mornex, J., Guillemain, R., Dahan, M., Knoop, C., Botturi, K., Pison, C., Nicod, L., Brouard, S., Magnan, A., Centre de Recherche en Transplantation et Immunologie (U1064 Inserm - CRTI), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), unité de recherche de l'institut du thorax UMR1087 UMR6291 (ITX), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Institut de Chimie Moléculaire et des Matériaux d'Orsay (ICMMO), Université Paris-Sud - Paris 11 (UP11)-Centre National de la Recherche Scientifique (CNRS)-Institut de Chimie du CNRS (INC), Service de Pneumologie, Nouvel Hôpital Civil Strasbourg, Clinique de pneumologie, CHU Grenoble, Recherche en épidémiologie et biostatistique, Université Paris-Sud - Paris 11 (UP11)-Institut National de la Santé et de la Recherche Médicale (INSERM), Intervention, innovation, imagerie, ingénierie en santé - UFC (I4S), Université de Franche-Comté (UFC), Université Bourgogne Franche-Comté [COMUE] (UBFC)-Université Bourgogne Franche-Comté [COMUE] (UBFC), and Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE)

Subjects
[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases
Abstract

American Transplant Congress, Chicago, IL, APR 29-MAY 03, 2017; International audience; no abstract

Published
2017

119. COLT : 10 ans de recherche en transplantation pulmonaire, résultats et perspectives

Author

Tissot, A., primary, Foureau, A., additional, Brosseau, C., additional, Danger, R., additional, Roux, A., additional, Bernasconi, E., additional, Gomez, C., additional, Durand, M., additional, Picard, B.R., additional, Le Pavec, J., additional, Claustre, J., additional, Lacoste, P., additional, Benmerad, M., additional, Pain, M., additional, Siroux, V., additional, Royer, P.-J., additional, Mordant, P., additional, Reynaud-Gaubert, M., additional, Kessler, R., additional, Brugière, O., additional, Mornex, J.-F., additional, Dromer, C., additional, Dahan, M., additional, Knoop, C., additional, Boussaud, V., additional, Koutsokera, A., additional, Botturi-Cavaillès, K., additional, Durand, E., additional, Loy, J., additional, Nicod, L., additional, Pison, C., additional, Brouard, S., additional, Blanc, F.-X., additional, and Magnan, A., additional

Published
2018
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124. Etude médico-économique de la dissection sous muqueuse. Les éléments modifiant la balance bénéfice/déficit en CHU

Author

Dahan, M, additional, Kerever, S, additional, Pauliat, E, additional, Legros, R, additional, Tailleur, A, additional, Richard, V, additional, Brischoux, S, additional, Carrier, P, additional, Lyva-Yonnet, S, additional, Loustaud-Ratti, V, additional, Sautereau, D, additional, Merle, L, additional, and Jacques, J, additional

Published
2018
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125. Airway microbiota signals anabolic and catabolic remodeling in the transplanted lung

Author

Mouraux, Stéphane, primary, Bernasconi, Eric, additional, Pattaroni, Céline, additional, Koutsokera, Angela, additional, Aubert, John-David, additional, Claustre, Johanna, additional, Pison, Christophe, additional, Royer, Pierre-Joseph, additional, Magnan, Antoine, additional, Kessler, Romain, additional, Benden, Christian, additional, Soccal, Paola M., additional, Marsland, Benjamin J., additional, Nicod, Laurent P., additional, Jougon, J., additional, Velly, J.-F., additional, Rozé, H., additional, Blanchard, E., additional, Dromer, C., additional, Antoine, M., additional, Cappello, M., additional, Ruiz, M., additional, Sokolow, Y., additional, Vanden Eynden, F., additional, Van Nooten, G., additional, Barvais, L., additional, Berré, J., additional, Brimioulle, S., additional, De Backer, D., additional, Créteur, J., additional, Engelman, E., additional, Huybrechts, I., additional, Ickx, B., additional, Preiser, T.J.C., additional, Tuna, T., additional, Van Obberghe, L., additional, Vancutsem, N., additional, Vincent, J.-L., additional, De Vuyst, P., additional, Etienne, I., additional, Féry, F., additional, Jacobs, F., additional, Knoop, C., additional, Vachiéry, J.L., additional, Van den Borne, P., additional, Wellemans, I., additional, Amand, G., additional, Collignon, L., additional, Giroux, M., additional, Angelescu, D., additional, Chavanon, O., additional, Hacini, R., additional, Pirvu, A., additional, Porcu, P., additional, Albaladejo, P., additional, Allègre, C., additional, Bataillard, A., additional, Bedague, D., additional, Briot, E., additional, Casez-Brasseur, M., additional, Colas, D., additional, Dessertaine, G., additional, Durand, M., additional, Francony, G., additional, Hebrard, A., additional, Marino, M.R., additional, Oummahan, B., additional, Protar, D., additional, Rehm, D., additional, Robin, S., additional, Rossi-Blancher, M., additional, Augier, C., additional, Bedouch, P., additional, Boignard, A., additional, Bouvaist, H., additional, Briault, A., additional, Camara, B., additional, Claustre, J., additional, Chanoine, S., additional, Dubuc, M., additional, Quétant, S., additional, Maurizi, J., additional, Pavèse, P., additional, Pison, C., additional, Saint-Raymond, C., additional, Wion, N., additional, Chérion, C., additional, Grima, R., additional, Jegaden, O., additional, Maury, J.-M., additional, Tronc, F., additional, Flamens, C., additional, Paulus, S., additional, Mornex, J.-F., additional, Philit, F., additional, Senechal, A., additional, Glérant, J.-C., additional, Turquier, S., additional, Gamondes, D., additional, Chalabresse, L., additional, Thivolet-Bejui, F., additional, Barnel, C., additional, Dubois, C., additional, Tiberghien, A., additional, Le Pimpec-Barthes, F., additional, Bel, A., additional, Mordant, P., additional, Achouh, P., additional, Boussaud, V., additional, Guillemain, R., additional, Méléard, D., additional, Bricourt, M.O., additional, Cholley, B., additional, Pezella, V., additional, Brioude, G., additional, D'Journo, X.B., additional, Doddoli, C., additional, Thomas, P., additional, Trousse, D., additional, Dizier, S., additional, Leone, M., additional, Papazian, L., additional, Bregeon, F., additional, Basire, A., additional, Coltey, B., additional, Dufeu, N., additional, Dutau, H., additional, Garcia, S., additional, Gaubert, J.Y., additional, Gomez, C., additional, Laroumagne, S., additional, Nieves, A., additional, Picard, L.C., additional, Reynaud-Gaubert, M., additional, Secq, V., additional, Mouton, G., additional, Baron, O., additional, Lacoste, P., additional, Perigaud, C., additional, Roussel, J.C., additional, Danner, I., additional, Haloun, A., additional, Magnan, A., additional, Tissot, A., additional, Lepoivre, T., additional, Treilhaud, M., additional, Botturi-Cavaillès, K., additional, Brouard, S., additional, Danger, R., additional, Loy, J., additional, Morisset, M., additional, Pain, M., additional, Pares, S., additional, Reboulleau, D., additional, Royer, P.-J., additional, Fabre, D., additional, Fadel, E., additional, Mercier, O., additional, Mussot, S., additional, Stephan, F., additional, Viard, P., additional, Cerrina, J., additional, Dorfmuller, P., additional, Ghigna, S.M., additional, Hervén, Ph., additional, Le Roy Ladurie, F., additional, Le Pavec, J., additional, Thomas de Montpreville, V., additional, Lamrani, L., additional, Castier, Y., additional, Cerceau, P., additional, Augustin, P., additional, Jean-Baptiste, S., additional, Boudinet, S., additional, Montravers, P., additional, Brugière, O., additional, Dauriat, G., additional, Jébrak, G., additional, Mal, H., additional, Marceau, A., additional, Métivier, A.-C., additional, Thabut, G., additional, Lhuillier, E., additional, Dupin, C., additional, Bunel, V., additional, Falcoz, P., additional, Massard, G., additional, Santelmo, N., additional, Ajob, G., additional, Collange, O., additional, Helms, O., additional, Hentz, J., additional, Roche, A., additional, Bakouboula, B., additional, Degot, T., additional, Dory, A., additional, Hirschi, S., additional, Ohlmann-Caillard, S., additional, Kessler, L., additional, Kessler, R., additional, Schuller, A., additional, Bennedif, K., additional, Vargas, S., additional, Stauder, J., additional, Ali-Azouaou, S., additional, Bonnette, P., additional, Chapelier, A., additional, Puyo, P., additional, Sage, E., additional, Bresson, J., additional, Caille, V., additional, Cerf, C., additional, Devaquet, J., additional, Dumans-Nizard, V., additional, Felten, M.-L., additional, Fischler, M., additional, Si Larbi, A.-G., additional, Leguen, M., additional, Ley, L., additional, Liu, N., additional, Trebbia, G., additional, De Miranda, S., additional, Douvry, B., additional, Gonin, F., additional, Grenet, D., additional, Hamid, A.M., additional, Neveu, H., additional, Parquin, F., additional, Picard, C., additional, Roux, A., additional, Stern, M., additional, Bouillioud, F., additional, Cahen, P., additional, Colombat, M., additional, Dautricourt, C., additional, Delahousse, M., additional, D'Urso, B., additional, Gravisse, J., additional, Guth, A., additional, Hillaire, S., additional, Honderlick, P., additional, Lequintrec, M., additional, Longchampt, E., additional, Mellot, F., additional, Scherrer, A., additional, Temagoult, L., additional, Tricot, L., additional, Vasse, M., additional, Veyrie, C., additional, Zemoura, L., additional, Berjaud, J., additional, Brouchet, L., additional, Dahan, M., additional, Mathe, F.O., additional, Benahoua, H., additional, DaCosta, M., additional, Serres, I., additional, Merlet-Dupuy, V., additional, Grigoli, M., additional, Didier, A., additional, Murris, M., additional, Crognier, L., additional, Fourcade, O., additional, Krueger, T., additional, Ris, H.B., additional, Gonzalez, M., additional, Jolliet, Ph., additional, Marcucci, C., additional, Chollet, M., additional, Gronchi, F., additional, Courbon, C., additional, Berutto, C., additional, Manuel, O., additional, Koutsokera, A., additional, Aubert, J.-D., additional, Nicod, L.P., additional, Mouraux, S., additional, Bernasconi, E., additional, Pattaroni, C., additional, Marsland, B.J., additional, Soccal, P.M., additional, Rochat, T., additional, Lücker, L.M., additional, Hillinger, S., additional, Inci, I., additional, Weder, W., additional, Schuepbach, R., additional, Zalunardo, M., additional, Benden, C., additional, Schuurmans, M.M., additional, Gaspert, A., additional, Holzmann, D., additional, Müller, N., additional, Schmid, C., additional, Vrugt, B., additional, Fritz, A., additional, Maier, D., additional, Deplanche, K., additional, Koubi, D., additional, Ernst, F., additional, Paprotka, T., additional, Schmitt, M., additional, Wahl, B., additional, Boissel, J.-P., additional, Olivera-Botello, G., additional, Trocmé, C., additional, Toussaint, B., additional, Bourgoin-Voillard, S., additional, Sève, M., additional, Benmerad, M., additional, Siroux, V., additional, Slama, R., additional, Auffray, C., additional, Charron, D., additional, Lefaudeux, D., additional, and Pellet, J., additional

Published
2018
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129. Impact du neuromonitoring des nerfs récurrents sur la fréquence des paralysies récurrentielles après thyroïdectomie totale. Résultats d’une étude prospective multicentrique

Author

Mirallié, E., primary, Caillard, C., additional, Pattou, F., additional, Brunaud, L., additional, Hamy, A., additional, Dahan, M., additional, Prades, J.M., additional, Mathonnet, M., additional, Landecy, G., additional, Dernis, P.H., additional, Lifante, J.C., additional, Sebag, F., additional, Jegoux, F., additional, Babin, E., additional, Bizon, A., additional, Espitalier, F., additional, Volteau, C., additional, and Blanchard, C., additional

Published
2017
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130. Impact du neuromonitoring des nerfs récurrents sur la fréquence des paralysies récurrentielles après thyroïdectomie totale. Résultats d’une étude prospective multicentrique

Author

Blanchard, C., primary, Caillard, C., additional, Pattou, F., additional, Brunaud, L., additional, Hamy, A., additional, Dahan, M., additional, Prades, M., additional, Mathonnet, M., additional, Landecy, G., additional, Dernis, H.P., additional, Lifante, J.C., additional, Sebag, F., additional, Jegoux, F., additional, Babin, E., additional, Bizon, A., additional, Espitalier, L., additional, Durand-Zaleski, I., additional, Volteau, C., additional, and Mirallié, E., additional

Published
2017
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133. Regulation of Cardiac Output in Cardiac Failure

Author

J. Y. Baglin, Pansard Y, R. Prasquier, Dahan M, M. C. Aumont, Juliard Jm, J. P. Merillon, and R. Gourgon

Subjects
medicine.medical_specialty, Cardiac output, business.industry, Internal medicine, Cardiology, medicine, business
Published
2015
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135. Effect of Addition of Zn, Cysteine, PGF2α and their Combination on Holstein Bulls Cooled Semen in vitro.

Author

Al-Dahan, M. R. G., Majeed, A. F., and Abed, M. A.

Subjects
SEMEN, SEMEN analysis, ZINC sulfate, CYSTEINE, BULLS
Abstract

Copyright of Al-Anbar Journal of Veterinary Sciences is the property of Republic of Iraq Ministry of Higher Education & Scientific Research (MOHESR) and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Published
2019
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136. Management of recurrent implantation failure by gonadotropin-releasing hormone agonist and aromatase inhibitor suppression, in women without evidence of endometriosis.

Author

Khayat, S., Elliott, B., and Dahan, M. H.

Subjects
AROMATASE inhibitors, OVARIAN reserve, EMBRYO transfer, OVARIAN cysts, ENDOMETRIOSIS
Abstract

Endometriosis is common among those with infertility, although many cases go undiagnosed. This study was performed to determine whether empiric treatment with two months of depo-leuprolide 3.75 mg monthly (dep-GnRH-ag) and letrozole 5 mg daily improves pregnancy outcomes in patients with at least two unexplained failed embryo transfers (ETs) but without a previous diagnosis of endometriosis. A retrospective cohort study was performed with subjects who failed at least two good quality ET. The study excluded women with a known history of endometriosis or ovarian cysts (possible endometriomas). Subjects (N = 38) were treated with dep-GnRH-ag and letrozole pre-cycle. Matched women (N = 37) who did not receive either pretreatment served as a control group. Data were compared by non-paired T-tests and multivariate logistic regression to control for confounding effects. Demographic data, hormonal profiles, and ovarian reserve parameters were similar between the two groups. The treated group had failed more embryo transfers (3.5 ± 1.7 vs. 2.0 ± 1.3, p = .01) than the controls. When adjusting for the number of MII oocytes collected, number of blastocysts developed and number of blastocysts transferred, there were more pregnancies (24/38 vs. 11/37, p = .02) and ongoing pregnancies (18/38 vs. 9/37, p = .03) in the treated group. Patients with multiple unexplained failed ET may have undiagnosed endometriosis and may benefit from pretreatment with dep-GnRH-ag and letrozole. These results would benefit from being subjected to a randomized prospective study. [ABSTRACT FROM AUTHOR]

Published
2019
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137. Trattamento chirurgico delle complicanze settiche dopo pneumonectomia

Author

Alifano, M., Daffré, E., and Dahan, M.

Abstract

La principale complicanza settica della pneumonectomia è il piotorace. Questo è associato una volta su due a una fistola broncopleurica che può essere la causa o la conseguenza di questo piotorace. Ciò significa che il loro trattamento è strettamente legato, con un doppio obiettivo: la sterilizzazione della cavità di pneumonectomia e la chiusura della fistola. In fase acuta, il primo trattamento è il drenaggio della loggia di pneumonectomia: esso ha lo scopo di prevenire l’inondazione del polmone controlaterale e di ottenere un controllo iniziale della sepsi locale. È seguito da un’irrigazione-lavaggio, eventualmente associata a una “toilette chirurgica” della cavità di pneumonectomia. In caso di fallimento, una toracostomia rappresenta spesso la migliore modalità di controllo locale della sepsi. Questa operazione è la tecnica di scelta quando il piotorace si accompagna a una fistola. Una volta che la fase acuta è controllata, si pone il problema dell’obliterazone dello spazio pleurico. Essa può essere ottenuta attraverso una mioplastica o un’omentoplastica, eventualmente precedute da una manovra di affossamento della tasca attraverso una toracoplastica. Quando la tasca è piccola, è possibile realizzare una chiusura semplice di toracostomia su una soluzione antibiotica (metodo di Clagett). L’uso della terapia a pressione negativa è un’opzione per le cavità senza fistola, perché accelera la detersione e favorisce la retrazione e la gemmazione. Per quanto riguarda le tasche relativamente piccole e ben curate dal drenaggio percutaneo, può essere proposta una toracoplastica senza fase preliminare di toracostomia. Nella pratica, le indicazioni dipendono più dalle caratteristiche del paziente, dalla complicanza settica e dalle abitudini del reparto che da un algoritmo immutabile e rigoroso.

Published
2024
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140. Nuclear target search at the single molecule level: protein interactions define the exploration landscape

Author

Izeddin, I., Récamier, V., Bosanac, L., Cissé, I. I., Boudarene, L., Dugast-Darzacq, C., Proux, F., Bénichou, O., Voituriez, R., Bensaude, O., Dahan, M., and Darzacq, X.

Abstract

Gene regulation relies on highly mobile transcription factors (TFs) exploring the nucleoplasm in search of their targets. Our view of the nucleus has evolved from that of an isotropic and homogenous reactor to that of a highly organized yet very dynamic organelle. However important questions remain on how these regulatory factors explore the nuclear environment in search of their DNA or protein targets, and how their exploration strategy affects the kinetics of transcriptional regulation. We implemented a single-molecule tracking assay to determine the TFs dynamics using photoactivatable tags in human cells. We investigated the mobility of several nuclear proteins, including the transcription factor c-Myc and the elongation factor P-TEFb. We found that, while their diffusion speed was comparable, these proteins largely differed in terms of their exploration geometry. We discovered that c-Myc is a global explorer diffusing in the nucleus without spatial constraints. In contrast, the positive transcription elongation factor P-TEFb is a local explorer that oversamples its environment, constrained by a fractal nuclear architecture. Consequently, each c-Myc molecule is equally available for all nuclear sites while P-TEFb reaches its targets in a position-dependent manner. We also measured the mobility of a P-TEFb mutant in which the interaction with the CTD of the RNA Pol II was truncated. In this case, the single-molecule experiments suggested a global exploration of the P-TEFb mutant, consistent with free diffusion. Our observations are in line with a model in which the exploration geometry of TFs is constrained by their interactions and not by exclusion properties. Our findings have strong implications on how proteins react in the nucleus and how their function can be regulated in space and time.

Published
2013

141. Empyème thoracique postpneumonectomie et scanographie dosimétrique. À propos de deux observations et revue de la littérature

Author

J. Berjaud, F. Arboucalot, I. Latorzeff, R. Aziza, J.M. Bachaud, Dahan M, and J. Giron

Subjects
Gynecology, medicine.medical_specialty, Oncology, medicine.diagnostic_test, business.industry, Lung disease, Respiratory disease, medicine, Radiology, Nuclear Medicine and imaging, Computed tomography, business, medicine.disease
Abstract

Resume Dans les suites d'une pneumonectomie pour cancer, les patients sont classiquement surveilles par l'examen clinique et la radiographie standard du thorax. Certaines formes torpides d'empyeme peuvent cependant passer inapercues quand elles surviennent apres la periode d'hospitalisation et qu'elles ne s'accompagnent pas de fievre. Lorsqu'une radiotherapie postoperatoire est realisee, la scanographie dosimetrique constitue dans ce cas le premier examen fournissant des donnees objectives du contenu endothoracique. Il faut donc, a cette occasion, s'assurer de la normalite de la loge de pneumonectomie en verifiant que le liquide de substitution est homogene et surtout que la partie interne, mediastinale, de la loge de pneumonectomie a un aspect concave. Si ce n'est pas le cas, un empyeme doit etre suspecte. Le diagnostic, confirme par l'examen cytobacteriologique du liquide pleural, constitue une contre-indication a la realisation de la radiotherapie. Nous presentons deux cas d'empyeme paucisymptomatique postpneumonectomie dont le diagnostic a ete etabli en cours de radiotherapie postoperatoire, alors que la scanographie dosimetrique initiale etait pathologique et aurait pu permettre un diagnostic plus precoce.

Published
1999
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