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BACKGROUND: Low-load resistance training with blood flow restriction (LL + BFR) attenuated delayed onset muscle soreness (DOMS) under some conditions. OBJECTIVE: The purpose of this study examined the effects of reciprocal concentric-only elbow flexion-extension muscle actions at 30% of peak torque on indices of DOMS. METHODS: Thirty untrained women (mean ± SD; 22 ± 2.4 years) were randomly assigned to 6 training days of LL + BFR (n= 10), low-load non-BFR (LL) (n= 10), or control (n= 10). Participants completed 4 sets (1 × 30, 3 × 15) of submaximal (30% of peak torque), unilateral, isokinetic (120∘s-1) muscle actions. Indices of DOMS including peak power, resting elbow joint angle (ROM), perceived muscle soreness (VAS), and pain pressure threshold (PPT) were assessed. RESULTS: There were no changes in peak power, ROM, or VAS. There was a significant interaction for PPT. Follow-up analyses indicated PPT increased for the LL + BFR condition (Day 5 > Day 2), but did not decrease below baseline. The results of the present study indicated LL + BFR and LL did not induce DOMS for the elbow extensors in previously untrained women. CONCLUSION: These findings suggested LL + BFR and LL concentric-only resistance training could be an effective training modality to elicit muscular adaptation without inducing DOMS.

OBJECTIVES To evaluate the efficacy of low-intensity focused ultrasound (LIFU) treatment on rapid relief of delayed-onset muscle soreness (DOMS) triggered by high-intensity exercise. METHODS A total of 16 healthy male college students were randomly divided into two groups: the LIFU group (n = 8) and the Sham group (n = 8). After the exercise protocol, the LIFU group received treatment, which parameters included that the power output was 2.5 W/cm2 , the frequency was 1 MHz, and the treating time was 20 minutes. The Sham group was treated with LIFU without energy output. Visual analog scale was used to evaluate the level of DOMS in every participant. The activities of plasma creatine kinase, lactate dehydrogenase, and the plasma concentration were measured by spectrophotometry. Tumor necrosis factor-α and interleukin-6 of serum were analyzed by enzyme-linked immunosorbent assay. RESULTS The visual analog scale of quadriceps femoris and/or calf muscles in the LIFU group decreased significantly at 24 hours (P

Objective: To investigate the effectiveness of pharmacological interventions in the treatment of delayed onset muscle soreness (DOMS). Design: A systematic review and meta-analysis of randomized controlled clinical trials (RCTs). Data sources: The PubMed/MEDLINE, EMBASE, SPORTDiscus, Scielo and Cochrane Central Register of Controlled Trials (CENTRAL) databases were searched for RCTs published prior to August 3, 2020. Eligibility criteria for selecting studies: Studies that 1) used an RCT design; 2) evaluated the effectiveness of steroidal or nonsteroidal anti-inflammatory drugs (NSAIDs) in treating DOMS; and 3) therapeutically used drugs after exercise were included. Results: In total, 26 studies (patients = 934) were eligible for inclusion in the qualitative analysis on the treatment of DOMS. The results of the meta-analysis showed no superiority between the use and non-use of NSAIDs in the improvement of late muscle pain, as no statistically significant differences were verified (21 studies, n= 955; standard mean difference (SMD)= 0.02; 95% confidence interval (CI) −0.58, 0.63; p=0.94; I2=93%). The quality of the synthesized evidence was very low according to the Grading of Recommendations Assessment, Development and Evaluation (GRADE) criteria, and there was significant heterogeneity among the included studies. Conclusion: The results demonstrate that NSAIDs are not superior to controls/placebos in treating DOMS. The inclusion of both studies with dose-response protocols and those with exercise protocols may have influenced the results. In addition, the high risk of bias identified reveals that limitations need to be considered when interpreting the results. Level of evidence I; ystematic review of RCT (Randomized and Controlled Clinical Trials). RESUMEN Objetivo: Investigar la efectividad de las intervenciones farmacológicas en el tratamiento del dolor muscular de aparición tardía (DOMS). Metodología: Revisión sistemática y metanálisis de ensayos clínicos controlados aleatorios (RCT). Fuentes de datos: Se realizaron búsquedas en las bases de datos de PubMed/MEDLINE, EMBASE, SPORTDiscus, Scielo y Cochrane Central Register of Controlled Trials (CENTRAL) para ECA publicados antes del 3 de agosto de 2020. Criterios de elegibilidad para la selección de estudios: Estudios en los que 1) se utilizó un diseño de RCT; 2) se evaluó la eficacia de los fármacos antiinflamatorios no esteroideos (AINE) y esteroideos en el tratamiento de DOMS; y 3) se incluyó el uso terapéutico de medicamentos para dolor después del ejercicio. Resultados: En total, 26 estudios (pacientes = 934) fueron elegibles para su inclusión en el análisis cualitativo sobre el tratamiento de DOMS. Los resultados encontrados en el metanálisis no demostraron superioridad entre el uso y no uso de AINE para mejorar el dolor muscular tardío cuando se comparó con una condición de control, ya que no hubo diferencias estadísticamente significativas (21 estudios, n = 955; media estándar diferencia = 0,02; intervalo de confianza (IC) del 95% −0,58, 0,63; p = 0,94; I2 = 93%). La calidad de la evidencia encontrada se clasificó como muy baja según los criterios del “Grading of Recommendations Assessment, Development and Evaluation” (GRADE), principalmente porque existe una heterogeneidad significativa entre los estudios incluidos. Conclusión: Los resultados demuestran que los AINE no son superiores a los controles o placebos en el tratamiento de DOMS. La inclusión de ambos modelos de estudio con protocolos de dosis-respuesta y protocolos de ejercicio puede haber influido en los resultados. Además, el alto riesgo de sesgo identificado revela que la interpretación de los resultados debe verse con limitaciones. Nivel de evidencia: I; Revisión sistemática de ECRC (Ensayos clínicos aleatorizados y controlados). RESUMO Objetivo: Investigar a eficácia das intervenções farmacológicas no tratamento da dor muscular de início tardio (DOMS). Desenho: Revisão sistemática e metanálise de estudos clínicos randomizados e controlados (RCTs). Fontes de dados: Os bancos de dados PubMed/MEDLINE, EMBASE, SPORTDiscus, Scielo e Cochrane Central Register of Controlled Trials (CENTRAL) foram pesquisados em busca de RCTs publicados antes de 3 de agosto de 2020. Critérios de elegibilidade para selecionar estudos: Estudos que 1) usaram um desenho de RCT; 2) avaliaram a eficácia de anti-inflamatórios esteroides ou não esteroides (AINEs) no tratamento de DOMS e 3) incluíram tratamento medicamentoso depois de exercício. Resultados: No total, 26 estudos (pacientes = 934) foram elegíveis para inclusão na análise qualitativa do tratamento de DOMS. Os resultados da metanálise não mostraram superioridade entre o uso e não uso de AINEs na melhora da dor muscular tardia, pois não foram verificadas diferenças estatisticamente significativas (21 estudos, n = 955; diferença média padronizada (SMD) = 0,02; Intervalo de confiança (IC) de 95% −0,58, 0,63; p = 0,94; I2 = 93%). A qualidade da evidência encontrada foi muito baixa de acordo com os critérios da Grading of Recommendations Assessment, Development and Evaluation (GRADE), e verificou-se heterogeneidade significante entre os estudos incluídos. Conclusão: Os resultados demonstram que os AINEs não são superiores aos controles ou placebos no tratamento de DOMS. A inclusão de estudos com protocolos de dose-resposta e com protocolos de exercícios podem ter influenciado os resultados. Além disso, o alto risco de viés identificado revela que as limitações devem ser consideradas na interpretação dos resultados. Nível de evidência I; Revisão sistemática de ECRC (Estudos clínicos randomizados e controlados).

Cluster sets (CS) are effective in maintaining performance and reducing perceived effort compared to traditional sets (TRD). However, little is known about these effects on adolescent athletes. The purpose of this study was to compare the effect of CS on the performance of mechanical and perceptual variables in young athletes. Eleven subjects [4 boys (age = 15.5 ± 0.8 years; body mass = 54.3 ± 7.0 kg; body height = 1.67 ± 0.04 m; Back Squat 1RM/body mass: 1.62 ± 0.19 kg; years from peak height velocity [PHV]: 0.94 ± 0.50) and 7 girls (age = 17.2 ± 1.4 years; body mass = 54.7 ± 6.3 kg; body height = 1.63 ± 0.08 m; Back Squat 1RM/body mass: 1.22 ± 0.16 kg; years from PHV: 3.33 ± 1.00)] participated in a randomized crossover design with one traditional (TRD: 3 × 8, no intra-set and 225 s interest rest) and two clusters (CS1: 3 × 2 × 4, one 30 s intra-set and 180 s inter-set rest; and CS2: 3 × 4 × 2, three 30 s intra-set and 90 s inter-set rest) protocols. The subjects were assessed for a Back Squat 1RM for the first meet, then performed the three protocols on three different days, with at least 48 h between them. During experimental sessions, a back squat exercise was performed, and mean propulsive velocity (MPV), power (MPP), and force (MPF) were collected to analyze performance between protocols, together with measures of countermovement jump (CMJ) and perceptual responses through Rating of Perceived Exertion for each set (RPE-Set) and the overall session (S-RPE), and Muscle Soreness (DOMS). The results showed that velocity and power decline (MVD and MPD) were favorable for CS2 (MVD: −5.61 ± 14.84%; MPD: −5.63 ± 14.91%) against TRD (MVD: −21.10 ± 11.88%; MPD: −20.98 ± 11.85%) (p < 0.01) and CS1 (MVD: −21.44 ± 12.13%; MPD: −21.50 ± 12.20%) (p < 0.05). For RPE-Set, the scores were smaller for CS2 (RPE8: 3.23 ± 0.61; RPE16: 4.32 ± 1.42; RPE24: 4.46 ± 1.51) compared to TRD (RPE8: 4.73 ± 1.33; RPE16: 5.46 ± 1.62; RPE24: 6.23 ± 1.97) (p = 0.008), as well as for Session RPE (CS2: 4.32 ± 1.59; TRD: 5.68 ± 1.75) (p = 0.015). There were no changes for jump height (CMJ: p = 0.985), and the difference between time points in CMJ (ΔCMJ: p = 0.213) and muscle soreness (DOMS: p = 0.437) were identified. Our findings suggest that using CS with a greater number of intra-set rests is more efficient even with the total rest interval equalized, presenting lower decreases in mechanical performance and lower perceptual effort responses.

BackgroundThere are multiple strategies that have been suggested to attenuate delayed-onset muscle soreness (DOMS). Caffeine has been shown to assist with blocking pain associated with DOMS. However, currently there is still controversy over the effects of caffeine use.Main bodyWe conducted a meta-analysis to compare pain associated with muscle soreness by both the VAS and indirect markers by CK of caffeine and placebo after exercise. The meta-analysis was carried out in accordance with the PRISMA guidelines. Relevant studies from Medline and Scopus published up to May 20, 2021, were included, which resulted in a total of 477 and 132 studies being retrieved from Scopus and Medline, respectively. Seven studies met the inclusion criteria, and in these, there were 68 persons in the caffeine group and 74 persons in the placebo group. A visual analog score of muscle soreness was recorded pre-exercise, immediately post-exercise, and at one to four days post-exercise; the scores at these time points in the caffeine group as compared to those in the placebo group progressed from 0.00 (95% CI − 0.51, 0.50) to − 0.20 (− 1.09, 0.69), − 0.92 (− 2.20, 0.36), − 1.02 (− 1.86, − 0.19), 0.00 (− 0.36, 0.36), and 0.18 (− 0.56, 0.92), respectively. No statistically significant differences were noted for CK between the two groups at 24 h post-exercise.Short conclusionOur meta-analysis results indicate that caffeine supplements reduce delayed-onset muscle soreness when compared to a placebo 48 h after exercise. However, at 24 h post-exercise, caffeine can reduce DOMS only in people who worked on resistant exercise. The CK used in this meta-analysis did not show any differences.Trial registration: PROSPERO CRD42021260248.Level of evidenceI.

Background There are multiple strategies that have been suggested to attenuate delayed onset muscle soreness (DOMS). Curcumin has been shown to reduce exercise-induced oxidative stress (OS) and inflammation. However, currently, there is still controversy. Main body of the abstract We conduct this meta-analysis according to the PRISMA guidelines. Relevant studies were included from Medline and Scopus from the date of inception to May 04th, 2021 that reported VAS score, blood markers (creatinine kinese (CK), tumor necrotic factor (TNF)-α and interleukin (IL)-6) and range of motion of either group. There were total of 13 studies including 202 and 176 persons in curcumin and placebo group. The unstandardized mean difference (UMD) of VAS muscle soreness in post-exercise, 1, 2, 3 and 4 days was − 0.12 (95% CI − 0.46, 0.22), − 0.38 (− 0.83, 0.08), − 0.67 (− 1.19, − 0.16), − 0.86 (− 1.38, − 0.34), − 0.81 (− 1.27, − 036) and − 1.24 (− 1.50, − 0.99) scores lower in curcumin when compared to placebo. The UMD of CK was − 11.07 (95% CI − 24, 1.86), − 37.51 (− 68.04, − 6.97), − 45.40 (− 95.67, 4.86), − 53.33 (− 128.11, 21.45), − 90.98 (− 173.45, − 8.51) and 117.84 (− 338.69, 574.37) lower in curcumin when compared to placebo. No statistically significantly differences were noted for IL-6, TNF-α and ROM between two groups. Short conclusion This meta-analysis suggested that curcumin supplement reduced delayed onset muscle soreness and CK after exercise in 1, 2, 3, and 4 days when compared to placebo. However, TNF and IL were not affected by curcumin ingestion. Level of evidence I.

Branched-chain amino acids (BCAA) are used as a recovery method after exercise-induced muscle damage (EIMD). Although data suggest that BCAA may alleviate the delayed-onset muscle soreness (DOMS) evoked by EIMD, there is no consensus about the most effective supplementation protocol. To investigate the effects of BCAA on DOMS after a single exercise session that caused EIMD, a systematic review and meta-analysis were conducted on the effectiveness of BCAA supplementation to reduce DOMS symptoms in healthy subjects after a single session of EIMD. Randomized clinical trials (RCT) were searched in Medline, Cochrane Library, Science Direct, SciELO, LILACS, SciVerse Scopus, Springer Link journals, Wiley Online Library, and Scholar Google, until May 2021. Ten RCTs were included in the systematic review and nine in the meta-analysis. Seven studies demonstrated that BCAA reduced DOMS after 24 to 72 h. BCAA doses of up to 255 mg/kg/day, or in trained subjects, for mild to moderate EIMD, could blunt DOMS symptoms. However, high variability between studies due to training status, different doses, time of treatment, and severity of EIMD do not allow us to conclude whether BCAA supplementation is efficient in untrained subjects, applied acutely or during a period of pre to post days of EIMD, and at higher doses (> 255 mg/kg/day). The overall effects of BCAA on DOMS after a single session of exercise were considered useful for improving muscle recovery by reducing DOMS in trained subjects, at low doses, in mild to moderate EIMD, and should not be administered only after the EIMD protocol.

Selmi, O, Goncalves, B, Levitt, DE, Ouergui, I, Sampaio, J, and Bouassida, A. Influence of well-being indices and recovery state on the technical and physiological aspects of play during small-sided games. J Strength Cond Res 35(10): 2802-2809, 2021-Soccer players performing at high level are frequently exposed to periods of intense training, which can induce substantial stress and fatigue. These high-intensity stimuli likely lead to a lower state of well-being and poor recovery and, consequently, may affect players' performance. This study aimed to assess the influence of well-being indices (i.e., self-ratings of sleep, stress, fatigue, and delayed onset muscle soreness [DOMS]) and the total quality of recovery (TQR) on technical and physiological measures during soccer small-sided games (SSGs). Twenty male professional soccer players (age: 25.1 ± 1.0 years) performed four 25-minute SSG sessions. Well-being indices were collected before each SSG-session. Heart rate was continuously measured throughout each session, and the ratings of perceived exertion and blood lactate concentration were collected after each SSG. A hierarchical cluster analysis was performed across variables and cases to identify associations between variables and variability in players' responses between sessions. No significant correlations were found between well-being indices, TQR and physiological parameters. Total quality recovery was positively correlated with successful pass % (r = 0.27) and interceptions (r = 0.25) and negatively correlated with lost balls (r = -0.25). Fatigue and DOMS were negatively correlated with tackles (r = -0.29, r = -0.28, respectively), successful pass % (r = -0.58, r = -0.55, respectively) and interceptions (r = -0.25, r = -0.27, respectively), and positively correlated with lost balls (r = 0.32, r = 0.28, respectively). Results provide an alternative and complementary method to understand training responses and can be an objective tool to help create subgroups in training for optimizing performance. This study demonstrates the efficacy and utility of using simple well-being and recovery measures to help coaches monitor athlete readiness.

The purpose of this study was to investigate acute Zembrin® (Sceletium tortuosum) supplementation on muscle soreness, markers of muscle damage, mood, and exercise performance following unaccustomed resistance exercise. Untrained females (n = 16) were divided into two groups with a different three-day treatment regimen: (1) placebo (PL) and (2) Zembrin® (ZEM). During the initial visit, baseline perceived soreness, range of motion (ROM), mood state (profile of mood states (POMS) questionnaire), and plasma lactate dehydrogenase concentrations (LDH) were measured followed by the performance of an eccentric bicep curl protocol with their non-dominant arm. The total repetitions and rate of perceived exertion (RPE) were recorded throughout the exercise. The participants then supplemented with the corresponding treatment immediately following, the subsequent day, and 30 min prior to completing a 48 h follow-up visit. For the 48 h visit, all procedures were repeated and comparisons were drawn for perceived soreness, ROM, LDH, mood scores, total repetitions, and RPE. The findings indicate that short-term ZEM supplementation resulted in lower perceived soreness (p = 0.020) and a greater preservation of ROM (p = 0.028) at 48 h versus the PL group. Mood worsened from the baseline to 48 h regardless of the treatment (p = 0.043) but the decrements were exacerbated in the PL group compared with the ZEM group (p &lt, 0.001). LDH levels (p = 0.019) and RPE (p = 0.008) were higher and total repetitions were lower (p &lt, 0.001) at 48 h irrespective of the treatment. Although short-term dietary enrichment with ZEM did not alter the exercise performance or biomarkers of muscle damage, the current results suggest ZEM supplementation may be effective in reducing the markers of soreness and preserve mood following unaccustomed eccentric exercise.

Previous studies showed that some medicinal herbs can prevent delayed onset muscle soreness (DOMS). The present study investigates the effect of Calendula officinalis supplementation on DOMS elements on male rowers. Thirty healthy adult male rowers were randomly chosen and equally divided into experimental and control groups. Blood samples, Sargent jumps (SJ), and pain perception tests were measured at the starting point. The experimental group consumed (twice a day, 200 μl each time) C. officinalis extract for a week while the control group received a placebo. After consuming the supplementations for a week, the second samples and tests were taken. All the athletes participated in the high-intensity interval exercise (HIIE – a muscle soreness protocol). Third, fourth, and fifth samples/tests were executed immediately, 24 and 48 h after HIIE. Statistical analysis was conducted and P≤0.05 was considered as the significant level. The results showed that HIIE induced a significant increase in the serum tumour necrosis factor-alpha (TNF-α) and creatine kinase-MB (CK-MB) values as well as the pain perception in both groups. TNF-α and pain perception were significantly lower in the experimental group immediately, 24 and 48 h after HIIE. CK-MB activity was significantly decreased in the experimental group during next 24 and 48 h after HIIE. The muscle soreness protocol and its preceding supplementation had no significant effect on SJ. The present study suggests that the consumption of C. officinalis based on the present study dose and timespan may be effective to attenuate inflammation and pain induced by HIIE in male rowers and probably has no functional impact on muscle.

Uvod: Zapoznela mišična bolečina je pogost pojav. Gre za posledice mikro mišičnih poškodb, ki nastanejo zaradi telesne dejavnosti, izrazitejša pa je pri ekscentričnem mišičnem delu. Simptomi zapoznele mišične bolečine se pojavijo od 12 do 24 ur po telesni dejavnosti, vrh pa dosežejo znotraj 72 ur. Ena izmed intervencij, ki se uporabljajo za lajšanje simptomov zapoznele mišične bolečine, je miofascialno sproščanje s penastim valjem. Gre za postopek samomasaže, pri kateri posamezniki za pritisk na mehkotkivne strukture uporabijo težo telesa. Obstajajo dokazi, da miofascialno sproščanje s penastim valjem izboljša obseg sklepne gibljivosti, zmanjša akutno mišično okorelost in občutenje zapoznele mišične bolečine. Namen: Namen diplomskega dela je na podlagi pregleda literature predstaviti učinkovitost miofascialnega sproščanja s pomočjo penastega valja na zmanjšanje zapoznele mišične bolečine. Metode dela: Iskanje literature je potekalo v podatkovni bazi PubMed z različnimi kombinacijami ključnih besed v angleščini: »delayed onset muscle soreness«, »foam rolling«, »myofascial release«, »exercise induced muscle damage« in »muscle recovery«. Iskanje literature je bilo omejeno na obdobje od leta 2011 do 2021. Vključene so bile kontrolirane randomizirane raziskave in raziskave, kjer so bili preiskovanci deljeni na kontrolno in intervencijsko skupino. V vključenih raziskavah so sodelovali samo zdravi preiskovanci. Rezultati: V pregled literature je bilo vključenih sedem raziskav, v katerih so avtorji želeli ugotoviti učinkovitost miofascialnega sproščanja s penastim valjem na zmanjšanje zapoznele mišične bolečine. V vseh raziskavah so izvedli protokole, s katerimi so povzročili z vadbo povzročene mišične poškodbe in izzvali zapoznelo mišično bolečino. V šestih raziskavah so primerjali rezultate med kontrolno skupino, ki ni bila deležna nobene terapije, in intervencijsko skupino, v kateri so preiskovanci izvajali miofascialno sproščanje s penastim valjem. V eni raziskavi pa so primerjali učinkovitost terapije z običajnim in vibracijskim penastim valjem. V šestih od sedmih vključenih raziskav so rezultati meritev nakazali, da se je občutenje bolečine pri preiskovancih, ki so bili deležni intervencije s penastim valjem, občutno zmanjšalo v primerjavi s preiskovanci iz kontrolne skupine. Razprava in zaključek: Iz pregledanih raziskav lahko sklepamo, da je miofascialno sproščanje s penastim valjem učinkovita tehnika pri zmanjševanju občutenja zapoznele mišične bolečine. Rezultati so sicer omejeni samo na zdrave mlade preiskovance, zato se jih ne da posplošiti na širšo populacijo. Potrebne so še dodatne raziskave z jasnejšimi določili terapevtskih parametrov. Introduction: Delayed onset muscle soreness is a common occurrence, it is a consequence of micro muscle damage which arise after physical activity, especially after eccentric muscle work. The symptoms of delayed onset muscle soreness appear 12 – 24 hours after physical activity and usually peak within the first 72 hours. One of the interventions, that is supposed to be effective in minimizing symptoms of delayed onset muscle soreness is myofascial release with foam rollers. It is a technique of self-massage, where individuals use their body mass to apply pressure on soft tissue structures. There is evidence, that besides lowering the perception of delayed onset muscle soreness, myofascial release is also effective in increasing range of motion and lowering acute muscle stiffness. Purpose: The purpose of this diploma work is to review the efficiency of myofascial release with foam rolling on reducing delayed onset muscle soreness. Methods: The literature search was proceeded through the PubMed article browser with the different combinations of keywords: »delayed onset muscle soreness«, »foam rolling«, »myofascial release«, »exercise induced muscle damage« in »muscle recovery«. We have searched for the articles published between years 2011 and 2021. Research that was included were randomized controlled trials and the ones where subjects under investigation were divided into control and foam rolling group. All the people included in analysed articles were healthy young adults without any injuries. Results: Seven articles were included in this literature review. In every analysed article exercised induced muscle damage protocols were performed to achieve delayed onset muscle soreness. In six articles comparisons were made between control group and intervention group, in which foam rolling protocols were performed. In one research they also compared effects of normal and vibration foam roller. In six out of seven research results have shown that people in intervention groups had reported greater decrease in perception of muscle pain compared to people in control group. Discussion and conclusion: From the current available results regarding efficiency of foam rolling on decreasing delayed onset muscle soreness we can conclude that it could be efficient. Although the results are limited only on healthy young adults. Regardless, some additional research are needed for clearer guided lines regarding therapeutic parameters.

Anthocyanins (ACN), the sub-class of (poly)phenols responsible for the red-blue-purple pigmentation of fruit and vegetables, have gained considerable interest in sport and exercise research due to their potential to facilitate exercise recovery. A systematic literature search was performed using PubMed, The Cochrane Library, MEDLINE, SPORTDiscus and CINAHL. Thirty nine studies were included and the standardized mean difference (Hedges g) for creatine kinase (CK), anti-oxidative and inflammatory markers, strength, power and delayed onset muscle soreness (DOMS) indices were pooled in separate meta-analyses; meta-regression was also performed on reported ACN dose. Immediately post-exercise there was an increase in antioxidant capacity (g: 0.56) and reduced C reactive protein (g: −0.24) and tumor necrosis factor α (g: −40); p ≤ 0.02. Strength was improved with ACN at all time points (g: 0.45–0.67). DOMS (g: −0.23) was lower 24 hours post-exercise and power was improved 24 hours (g: 0.62) and 48 hours (g: 0.57) post exercise. The CK was lower 48 hours post-exercise (g: −0.31) and there was a trend for a positive association with ACN dose (p = 0.057). This systematic review provides new data showing ACN-rich foods promote functional and subjective recovery likely due to the antioxidant and anti-inflammatory properties of ACN.

Introdução: O alongamento estático é comumente utilizado como parte da rotina de preparação para o exercício físico, no entanto ainda é controversa a sua influência sobre a inibição e ou redução dos danos musculares ocasionados pelo exercício excêntrico. Objetivo: Analisar o efeito do uso de um protocolo de alongamento estático com duração de 5 min (5 x 60 s) pré-exercício na resposta da concentração de creatina quinase ([CK]) e dor muscular de início tardio (DMIT) 24 e 48 horas após exercício de saltos pliométricos. Métodos: Trata-se de um estudo quase-experimental contrabalanceado de medidas repetidas e a amostra foi composta por 10 voluntários saudáveis que foram submetidos a duas sessões experimentais: 1) sem alongamento prévio ao exercício (controle) e; 2) com alongamento estático prévio ao exercício (alongamento estático). Em ambas as sessões os participantes foram submetidos a um exercício de saltos pliométricos para indução de dano muscular. Previamente às sessões experimentais e 24 e 48 horas pós-exercício foi mensurada a [CK], bem como a DMIT 24 e 48 horas pós-exercício. Resultados: Não houve diferença significativa para [CK] e DMIT quando comparadas as sessões experimentais, controle e alongamento estático, (p > 0,05). Além disso, ambas obtiveram pico da [CK] 24 horas pós-exercício, e a DMIT foi classificada como irritante para ambas as sessões. Conclusão: O protocolo de alongamento estático com duração de cinco minutos (5 x 60s) prévio ao exercício de saltos pliométricos não minimizou ou inibiu os danos musculares associados às ações excêntricas avaliadas pela [CK] e DMIT.

Background/Objective The purpose of this investigation was to evaluate the effects of foam rolling (FR) and passive recovery (PR) on symptoms of delayed-onset muscle soreness (DOMS) and military-specific performance. Methods Twenty men and women (age: 23.6 ± 4.1 years, height: 176.4 ± 5.6 cm, and body mass: 84.7 ± 13.4 kg) completed a DOMS-inducing exercise protocol (DIP), followed by FR or PR. Four loaded military tasks (LMT) were performed 24 h later. Rating of perceived exertion (RPE) was measured during DIP and after each LMT. Rating of muscle pain (RMP) was measured prior to the LMTs and after the recovery protocols. A repeated measure analysis of variance and partial eta squared were used to compare LMT performance across baseline, FR and PR sessions. Friedman tests compared perceptual variables across baseline, FR, and PR. Wilcoxon matched-pairs signed-ranks test evaluated RPE during DIP, post-DIP, and post-recovery RMP between FR and PR. Results LMT performance times were significantly faster after FR compared to PR (stair climb: p = .038, cover position sprint: p = .011, simulated ammunition can carry: p = .003, Shuttle Run: p = .034). RPE measured during LMTs was similar across all data points. Post-recovery RMP for FR (3.0 (2.3, 4.0)) and PR (4.0 (3.0, 6.0)) were not significantly different. Conclusion FR reduced the impact of DOMS on three loaded tactical performance tasks without significant reduction in perceived soreness.

The aim of this investigation was to determine if acute or repeated applications of ischemic preconditioning (IPC) could enhance the recovery process, following exercise induced muscle damage (EIMD).Randomized control trial.Twenty-three healthy males were familiarised with the muscle damaging protocol (five sets of 20 drop jumps from a 0.6 m box) and randomly allocated to one of three groups: SHAM (3 × 5 min at 20 mmHg), Acute IPC (3 × 5 min at 220 mmHg) and Repeated IPC (3 days x 3 × 5 min at 220 mmHg). The indices of muscle damage measured included creatine kinase concentration ([CK]), thigh swelling, delayed onset muscle soreness, counter movement jumps (CMJ) and maximal voluntary isometric contraction (MVIC).Both acute and repeated IPC improved recovery in MVIC versus SHAM. Repeated IPC led to a faster MVIC recovery at 48 h (101.5%) relative to acute IPC (92.6%) and SHAM (84.4%) (P 0.05). Less swelling was found for both acute and repeated IPC vs. SHAM (P 0.05) but no group effects were found for CMJ, soreness or [CK] responses (P 0.05).Taken together, repeated IPC can enhance recovery time of MVIC more than an acute application, and both reduce swelling following EIMD, relative to a SHAM condition.

Long distance running (LDR) is an exercise that has a relatively heavy load which can cause Delayed Onset Muscle Soreness (DOMS) and increase Reactive Oxygen Species (ROS) levels. Xanthine, one derivate of ROS will increase 10 times during aerobic activity which is metabolized to Uric Acid (mg/dL) (UA). Foam rolling (FR) is used for the recovery process. This study aims to determine the effect of long distance running on changes in UA levels and the effect of FR as an active recovery against changes in UA levels. This was a quasi-experiment study using a purposive sampling design, one-group repeated measure design of a sample population of young healthy males (17-25 years). The sample consisted of 10 trained young males in Semarang. The average value of UA before intervention was 4.43 mg/dL ± 0.51. In 90 minutes, it was 5.90 mg/dL ± 0.52, in 120 minutes was 5.71 mg/dL ± 0.72 and at 24 hours after intervention was 6.1 mg/dL ± 0.57. LDR has been shown to increase UA levels. FR which is done only once has not been able to reduce UA levels. The percentage of occurrence of post-LDR DOMS occurred at 24 hours.

There is growing evidence that suggests that n-3 polyunsaturated fatty acids (PUFA) may improve physical performance when combined with proper training through modulation of muscle hypertrophy, muscle strength, and delayed onset muscle soreness (DOMS). This systematic review aims to examine the effect and optimal dosage of n-3 PUFA supplementation on muscle hypertrophy, muscle strength, and DOMS when combined with physical exercise. The PubMed, Web of Science, MEDLINE Complete, CINAHL and SPORTDiscus databases were searched following the PRISMA guidelines. Randomized controlled trials performed with healthy humans were considered. Fifteen studies with a total of 461 individuals were included in this systematic review. All of them measured muscle function (short physical performance test, range of motion (ROM), electromechanical delay (EMD), muscle echo intensity or muscle quality) and DOMS. Fourteen studies evaluated muscle strength and only six assessed muscle hypertrophy. Our results demonstrated that n-3 PUFA does not improve muscle hypertrophy, muscle strength or skeletal muscle biomarkers of inflammation and muscle damage beyond the benefits obtained by the training itself. Nevertheless, n-3 PUFA improves DOMS recovery and muscle function (measured by ROM, EMD and muscle quality).

The lumbar region offers various muscle recruitment strategies to achieve a task goal under varying conditions. For instance, trunk movement control can be reorganized under the influence of low back pain. How such task-modulation is obtained is not fully understood. The objective of this study was to characterize superficial lumbar muscle recruitment strategies under the influence of delayed-onset muscle soreness (DOMS) during unexpected trunk perturbations. Healthy participants experienced a series of 15 sudden external perturbations with and without the influence of low back DOMS. During these perturbations, high-density surface electromyography was used to characterize recruitment strategies of superficial lumbar muscles, while kinematics sensors were used to characterize movements of the trunk. Lumbar muscle recruitment strategies, characterized by the amplitude of muscle activity amplitude, the latencies of the reflex activity and the spatial distribution of muscle activity, were compared across perturbations trials and with and without DOMS. An attenuation of lumbar muscle activity amplitude was observed across perturbation trials without DOMS, but not with DOMS. The spatial distribution of muscle activity was similar with and without DOMS. No significant changes in reflex activity latency and trunk flexion movement were observed. Following an unexpected trunk perturbation under DOMS effects, trunk movement are controlled using two different superficial lumbar muscles control strategies: keeping a constant level of their overall muscle activity and using a variable muscle recruitment pattern.

Background: Delayed onset muscle soreness (DOMS) is a common experience after unusual activities particularly eccentric exercises. The aim of the present study was to investigate the effect of grape seed extract (GSE) on some factors of DOMS on non-athletic female students. Method: Twenty young healthy female students were randomly allocated into two experimental (GSE=10n) and placebo (PLC=10n) groups. T produce DOMS, a forty-five repetition of eccentric elbow curl in three sets was performed. Venous blood samples were obtained before and after supplementation, immediately, 24h, and 48h after exercise for analysis of creatine kinase (CK), lactate dehydrogenase (LDH). The pain was assessed by visual analogue scale (VAS). Results: There was a significant increase in CK activity after exercise compared with before exercise in both groups (P0.05). Furthermore, The VAS scores were significantly lower in GSE compared with PLC group 24h and 48h after exercise (P

Clinical Scenario: Endurance sports require a great deal of physical training to perform well. Endurance training and racing stress the skeletal muscle, resulting in exercise-induced muscle damage (EIMD). Athletes attempt to aid their recovery in various ways, one of which is through compression. Dynamic compression consists of intermittent pneumatic compression (IPC) devices, such as the NormaTec Recovery System and Recovery Pump. Clinical Question: What are the effects of IPC on the reduction of EIMD in endurance athletes following prolonged exercise? Summary of Key Findings: The current literature was searched to identify the effects of IPC, and 3 studies were selected: 2 randomized controlled trials and 1 randomized cross-over study. Two studies investigated the effect of IPC on delayed onset muscle soreness and plasma creatine kinase in ultramarathoners. The other looked at the impact of IPC on delayed onset muscle soreness in marathoners, ultramarathoners, triathletes, and cyclists. All studies concluded IPC was not an effective means of improving the reduction of EIMD in endurance-trained athletes. Clinical Bottom Line: While IPC may provide short-term relief of delayed onset muscle soreness, this device does not provide continued relief from EIMD. Strength of Recommendation: In accordance with the Strength of Recommendation Taxonomy, the grade of B is recommended based on consistent evidence from 2 high-quality randomized controlled trials and 1 randomized cross-over study.

Peripheral muscle fatigue is a common experience in daily life. Every individual at some point in their life has realized the inability to maintain muscle contraction, a phenomenon known as fatigue. Interestingly, neurological patients with peripheral sequelae such as spastic muscle contraction are able to remain in a pattern of muscle contraction for prolonged periods. The effects of laser therapy are already recognized in muscle contraction to delay skeletal muscle fatigue, prolong physical activity, and reduce delayed onset muscle soreness. However, the effects of photobiomodulation on neurological patients with muscular spasticity are still not well established. The present literature review seeks to recognize articles about the application of laser irradiation, also known as photobiomodulation, to patients with muscle fatigue and/or spastic palsy. To perform a literature review, we used the systematic review methodology for the literature search. The following keywords were searched: (skeletal muscle fatigue) AND (spastic patients) AND (low-level laser therapy OR low intensity laser therapy OR low energy laser therapy OR LLLT OR LILT OR LELT OR infrared laser OR IR laser OR diode laser), and these were used for search on the following databases: PubMed, Embase, Web of Science, BIREME, Scopus, and SciELO. Besides that, a literature review concerning on muscle physiology, fatigue, and LLLT was made. No language filter was applied, and altogether, 689 papers were identified. A group of 3 physiotherapists and 01 pharmaceutical scientist performed the literature review, and every exclusion was confirmed by at least two reviewers. After inclusion and exclusion criteria, 128 studies were included in this review. Conclusion, the LLLT can contribute to the recovery of spastic patients and muscles in fatigue. However, the real effect of laser photobiomodulation on muscle spasticity remains to be established. Only a much reduced number of clinical trials have been performed with a small number of participants. There is a lack of clinical trials from different research groups that could help to understand and elucidate the effects of laser in prolonged muscle contraction in spastic palsy.

This literature review investigates the effects of obesity on exercise-induced muscle injury and reexamines the potential mechanisms of exercise-induced muscle injury related to obesity. Several studies reported that high body mass index and percent body fat can significantly affect the markers of muscle injury after exercise, including maximal strength, delayed onset muscle soreness, creatinine kinase level, and myoglobin level. The potential mechanisms resulting in these outcomes include structural changes in the cell membrane induced by high fat levels, increased inflammatory responses due to adipose tissues, reduced muscle satellite cell activation and myogenesis due to lipid overload, differences in muscle fiber distributions, and sedentary behaviors. These mechanisms, however, must be verified through more research. As obesity is a potential risk factor increasing the severity of exercise-induced muscle injuries, the exercise intensity and duration for obese patients must be carefully selected, and a preconditioning intervention (e.g., low-intensity eccentric training) may be considered before or during the early stages of the exercise program.