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101. T06.01.2 ESBLE AND MRSA FAECAL CARRIAGE IN CIRRHOTIC PATIENTS: A RETROSPECTIVE STUDY ON CLINICAL OUTCOMES BEFORE AND AFTER LIVER TRANSPLANTATION

Author

Fabio Conti, Olivier Scatton, C. Cammà, V. Martinez, A. Mazzola, Claire Goumard, Bianca Magro, Mona Munteanu, and D. Bernard

Subjects
medicine.medical_specialty, Hepatology, business.industry, medicine.medical_treatment, Internal medicine, Gastroenterology, medicine, Retrospective cohort study, Liver transplantation, Faecal carriage, business
Published
2020
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102. Modeling humanTBX5haploinsufficiency predicts regulatory networks for congenital heart disease

Author

Reuben Thomas, Giovanni Iacono, Fei Gu, W. Patrick Devine, Tatyana Sukonnik, Bayardo I. Garay, Christine E. Seidman, Jonathan G. Seidman, Kai Li, Kavitha S. Rao, Benoit G. Bruneau, Henry Gong, Swetansu K. Hota, Irfan S. Kathiriya, William T. Pu, Andrew Blair, Piyush Goyal, Brynn N. Akerberg, Lauren K. Wasson, Laure D. Bernard, Gunes A. Akgun, Michael H. Lai, Holger Heyn, and Joshua M. Stuart

Subjects
0303 health sciences, Heart disease, Gene regulatory network, Biology, medicine.disease, Cell biology, 03 medical and health sciences, 0302 clinical medicine, 030220 oncology & carcinogenesis, Transcriptional regulation, medicine, MEF2C, Induced pluripotent stem cell, Haploinsufficiency, Gene, Transcription factor, 030304 developmental biology
Abstract

Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD). However, underlying CHD gene regulatory network (GRN) imbalances are unknown. Here, we define transcriptional consequences of reduced dosage of the CHD-linked transcription factor, TBX5, in individual cells during cardiomyocyte differentiation from human induced pluripotent stem cells (iPSCs). We discovered highly sensitive dysregulation of TBX5-dependent pathways— including lineage decisions and genes associated with cardiomyocyte function and CHD genetics—in discrete subpopulations of cardiomyocytes. GRN analysis identified vulnerable nodes enriched for CHD genes, indicating that cardiac network stability is sensitive to TBX5 dosage. A GRN-predicted genetic interaction betweenTbx5andMef2cwas validated in mouse, manifesting as ventricular septation defects. These results demonstrate exquisite sensitivity to TBX5 dosage by diverse transcriptional responses in heterogeneous subsets of iPSC-derived cardiomyocytes. This predicts candidate GRNs for human CHDs, with implications for quantitative transcriptional regulation in disease.

Published
2019
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104. Capitellar Osteochondritis Dissecans Lesions of the Elbow: A Systematic Review of Osteochondral Graft Reconstruction Options

Author

Christopher L. Camp, Devin P. Leland, Shawn W. O'Driscoll, Zhen Wang, Aaron J. Krych, Joaquin Sanchez-Sotelo, Mark E. Morrey, Christopher D. Bernard, and Anthony L. Logli

Subjects
Allograft transplantation, medicine.medical_specialty, Elbow, MEDLINE, CINAHL, 03 medical and health sciences, 0302 clinical medicine, Elbow Joint, Medicine, Humans, Orthopedics and Sports Medicine, Orthopedic Procedures, Autografts, 030222 orthopedics, Bone Transplantation, business.industry, 030229 sport sciences, Evidence-based medicine, Plastic Surgery Procedures, medicine.disease, Osteochondritis dissecans, Magnetic Resonance Imaging, Osteochondritis Dissecans, Surgery, medicine.anatomical_structure, Systematic review, business, Complication
Abstract

Purpose To systematically evaluate the outcomes and complications of osteochondral autograft transfer (OAT) and osteochondral allograft transplantation (OCA) for the surgical treatment of capitellar osteochondritis dissecans (OCD). Methods A literature search was conducted across 3 databases (PubMed, Cochrane, and CINAHL [Cumulative Index to Nursing and Allied Health Literature]) from database inception through December 2019 in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) guidelines. Individual study quality was assessed using the Methodological Index for Non-randomized Studies scale. Studies were published between 2005 and 2019. Results Eighteen studies consisting of 446 elbow OCD lesions treated with OAT surgery were included. There was a single OCA study eligible for inclusion. Patient ages ranged from 10 to 45 years. Of the OAT studies, 4 used autologous costal grafts whereas the remainder used autografts from the knee. Outcome measures were heterogeneously reported. A significant improvement in Timmerman-Andrews scores from preoperatively to postoperatively was reported in 9 of 10 studies. Return-to-play rates to the preinjury level of competitive play ranged from 62% to 100% across 16 studies. Significant improvement in motion, most often extension, was noted in most studies. Reported complication, reoperation, and failure rates ranged from 0% to 11%, 0% to 26%, and 0% to 20%, respectively. When used, knee autografts resulted in low donor-site morbidity (Lysholm scores, 70-100). Conclusions OAT surgery for large, unstable OCD lesions of the capitellum reliably produced good outcomes, few complications, and a high rate of return to competitive play. Complications are relatively uncommon, and donor-site morbidity is low. Less is known about the performance of OCA given the paucity of available literature. Level of Evidence Level IV, systematic review of Level II to IV studies.

Published
2019

105. Extraction of form Factors from a Four-Dimensional Angular Analysis of B¯→D*ℓ−ν¯ℓ

Author

V. B. Golubev, T. E. Latham, M. Carpinelli, D. B. MacFarlane, M. Rama, M. Rotondo, G. De Nardo, M. Röhrken, J. L. Ritchie, W. R. Innes, R. Y. So, A. Roodman, R. Sacco, Yu G. Kolomensky, J. P. Lees, R. M. Seddon, A. J.S. Smith, Roland Waldi, F. Ferroni, J. Dorfan, N. Tasneem, V. Santoro, Simon Akar, C. Bünger, J. J. Walsh, E. A. Kozyrev, B. T. Meadows, G. Raven, Paul Fraser Harrison, M. D. Sokoloff, P. R. Burchat, H. A. Neal, G. Casarosa, W. J. Wisniewski, D. N. Brown, Ju-Young Kim, Stephen Robert Wagner, Aidan Randle-Conde, G. R. Bonneaud, B. Bhuyan, A. Jawahery, R. Kowalewski, P. Ongmongkolkul, A. P. Onuchin, B. G. Fulsom, G. J. King, G. Cibinetto, M. K. Sullivan, S. Martellotti, C. H. Cheng, James R. Wilson, Andrei Gritsan, R. Gorodeisky, D. A. Roberts, V. Poireau, A. Hafner, E. M. T. Puccio, R. de Sangro, S. L. Wu, M. Piccolo, I. M. Nugent, R. Calabrese, G. Batignani, Crisostomo Sciacca, G. Rizzo, G. D. Lafferty, E. Ben-Haim, D. S. Chao, A. M. Lutz, A. R. Buzykaev, M. S. Alam, M. Davier, S. Passaggio, M. V. Purohit, S. H. Robertson, S. Emery, J. Albert, A. Beaulieu, J. Chauveau, F. De Mori, A. Palano, Herbert Koch, Heiko Lacker, J. M. Roney, S. Luitz, P. Patteri, J. Va’vra, A. M. Rossi, Joseph Izen, K. Griessinger, W. Dunwoodie, J. Ocariz, E. Fioravanti, J. G. Smith, G. Eigen, Florian Urs Bernlochner, F. Palombo, T. Lueck, M. Ebert, K. R. Schubert, Stephen Sekula, J. W. Gary, Abner Soffer, T. S. Miyashita, R. Cheaib, V. P. Druzhinin, C. Bozzi, K. Honscheid, V. E. Blinov, J. M. LoSecco, Z. C. Huard, W. Panduro Vazquez, F. Di Lodovico, D. J. Payne, R. J. Barlow, Tim Adye, B. G. Pushpawela, R. D. Kass, P. Taras, E. P. Solodov, M. Posocco, T. S. Mattison, Alessandro Pilloni, W. S. Lockman, D. R. Peimer, C. Hast, D. J. Lange, G. Piredda, F. Anulli, A. Filippi, J. A. McKenna, D. W. G. S. Leith, Alessandro Gaz, G. Calderini, E. Paoloni, R. Cowan, D. Gamba, J. P. Coleman, M. Bellis, Martino Margoni, T. J. Gershon, Maurizio Biasini, R. F. Schwitters, Owen Rosser Long, K. Yu Todyshev, R. Stroili, L. Sun, A. Oyanguren, span>B ar, Adrian John Bevan, F. Simonetto, S. Prell, I. Garzia, James H Cochran, A. Lusiani, C. Touramanis, C. L. Davis, X. C. Lou, R. Godang, P. C. Kim, O. Grünberg, M. Heß, M. Fritsch, R. Cenci, A. Zallo, Yu I. Skovpen, C. Hearty, Elisa Manoni, B. Echenard, D. J. Summers, D. Aston, D. Bernard, M. Bomben, R. J. Sobie, L. Vitale, F. Martinez-Vidal, Dominik Müller, span, N. Guttman, E. Luppi, M. T. Graham, Colin Jessop, R. Prepost, I. M. Peruzzi, G. Marchiori, E. A. Kravchenko, S. I. Serednyakov, G. Vasseur, K. T. Flood, F. Bianchi, J. A. Ernst, Douglas Wright, S. Dittrich, E. Gabathuler, F. C. Porter, E. Grauges, L. Zani, D. E. Hutchcroft, T. Leddig, W. Gradl, Mario Giorgi, R. Faccini, M. Chrzaszcz, M. R. Convery, C. Voß, F. Ferrarotto, A. J. Lankford, F. Le Diberder, A. M. Eisner, L. Lanceri, B. N. Ratcliff, Sw. Banerjee, Biplab Dey, G. Simi, Hamad Ahmed, D. Bettoni, N. Arnaud, A. Calcaterra, C. Cartaro, G. Finocchiaro, C. Patrignani, V. Tisserand, A. G. Denig, S. Bettarini, F. F. Wilson, B. Oberhof, G. A. Cowan, C. H. Chen, S. M. Spanier, G. Wormser, Y. Li, M. Verderi, T. Schroeder, U. Mallik, N. Neri, L. M. Cremaldi, D. G. Hitlin, R. C. Field, and F. Forti

Subjects
Physics, Quantum chromodynamics, Semileptonic decay, Particle physics, Meson, 010308 nuclear & particles physics, Branching fraction, Electron–positron annihilation, Crossing, Form factor (quantum field theory), General Physics and Astronomy, 01 natural sciences, 0103 physical sciences, High Energy Physics::Experiment, B meson, 010306 general physics
Abstract

An angular analysis of the decay B[over ¯]→D^{*}l^{-}ν[over ¯]_{l}, l∈{e,μ}, is reported using the full e^{+}e^{-} collision data set collected by the BABAR experiment at the ϒ(4S) resonance. One B meson from the ϒ(4S)→BB[over ¯] decay is fully reconstructed in a hadronic decay mode, which constrains the kinematics and provides a determination of the neutrino momentum vector. The kinematics of the semileptonic decay is described by the dilepton mass squared, q^{2}, and three angles. The first unbinned fit to the full four-dimensional decay rate in the standard model is performed in the so-called Boyd-Grinstein-Lebed approach, which employs a generic q^{2} parametrization of the underlying form factors based on crossing symmetry, analyticity, and QCD dispersion relations for the amplitudes. A fit using the more model-dependent Caprini-Lellouch-Neubert (CLN) approach is performed as well. Our form factor shapes show deviations from previous fits based on the CLN parametrization. The latest form factors also provide an updated prediction for the branching fraction ratio R(D^{*})≡B(B[over ¯]→D^{*}τ^{-}ν[over ¯]_{τ})/B(B[over ¯]→D^{*}l^{-}ν[over ¯]_{l})=0.253±0.005. Finally, using the well-measured branching fraction for the B[over ¯]→D^{*}l^{-}ν[over ¯]_{l} decay, a value of |V_{cb}|=(38.36±0.90)×10^{-3} is obtained that is consistent with the current world average for exclusive B[over ¯]→D^{(*)}l^{-}ν[over ¯]_{l} decays and remains in tension with the determination from inclusive semileptonic B decays to final states with charm.

Published
2019
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106. The SIFK score: a validated predictive model for arthroplasty progression after subchondral insufficiency fractures of the knee

Author

Aaron J. Krych, Christopher D. Bernard, Ayoosh Pareek, Daniel B.F. Saris, Chad W. Parkes, and Matthew P. Abdel

Subjects
Male, medicine.medical_specialty, Fractures, Stress, Knee Joint, medicine.medical_treatment, Radiography, Dentistry, Menisci, Tibial, 03 medical and health sciences, 0302 clinical medicine, Lasso regression, Risk Factors, medicine, Insufficiency fracture, Humans, Orthopedics and Sports Medicine, Arthroplasty, Replacement, Knee, Interpretability, Aged, Retrospective Studies, Lateral meniscus, 030222 orthopedics, Models, Statistical, business.industry, 030229 sport sciences, Middle Aged, musculoskeletal system, Arthroplasty, Magnetic Resonance Imaging, Tibial Meniscus Injuries, medicine.anatomical_structure, Orthopedic surgery, Disease Progression, Surgery, Female, business, Medial meniscus
Abstract

The purpose of this study was to create a predictive model utilizing baseline demographic and radiographic characteristics for the likelihood that a patient with subchondral insufficiency fracture of the knee will progress to knee arthroplasty with emphasis on clinical interpretability and usability. A retrospective review of baseline and final radiographs in addition to MRIs were reviewed for evaluation of insufficiency fractures and associated injuries. Patient and radiographic factors were used in building predictive models for progression to arthroplasty with Train: Validation: Test subsets. Multiple models were compared with emphasis on clinical utility. Total of 249 patients with a mean age of 64.6 (SD 10.5) years were included. Knee arthroplasty rate was 27% at mean of 4 years of follow-up. Lasso Regression was non-inferior to other models and was chosen for ease of interpretability. In order of importance, predictors for progression to arthroplasty included lateral meniscus extrusion, Kellgren–Lawrence Grade 4, SIFK on MFC, lateral meniscus root tear, and medial meniscus extrusion. The final SIFK Score stratified patients into low-, medium-, and high-risk categories with arthroplasty rates of 8.8%, 40.4%, and 78.9% (p

Published
2019

107. Medial Closing Wedge Distal Femoral Osteotomy

Author

Christopher D. Bernard, Michael J. Stuart, Nicholas C. Duethman, Aaron J. Krych, and Christopher L. Camp

Subjects
musculoskeletal diseases, Knee Joint, Radiography, Arthritis, Physical Therapy, Sports Therapy and Rehabilitation, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Orthopedics and Sports Medicine, Femur, Mechanical axis, Closing wedge, Distal femoral osteotomy, Orthodontics, 030222 orthopedics, biology, business.industry, 030229 sport sciences, musculoskeletal system, biology.organism_classification, medicine.disease, Osteotomy, Valgus, medicine.anatomical_structure, Preoperative Period, Ankle, business
Abstract

The main indication for performing a distal femoral osteotomy is valgus malalignment of the knee joint. The ideal candidates are young and active individuals with isolated lateral compartment arthritis. The goal of the procedure is to create a neutral mechanical axis of the limb to relieve pain and preserve the knee joint. The amount of correction is calculated from a preoperative, high-quality, weight-bearing radiograph from the hip to ankle. This technically challenging operation is a viable option for patients with valgus malalignment because early survivorship is strong and patient-reported outcome scores are significantly improved.

Published
2019

108. Pre-operative patella alta does not affect midterm clinical outcomes and survivorship of patellofemoral arthroplasty

Author

Christopher D, Bernard, Ayoosh, Pareek, Casey M, Sabbag, Chad W, Parkes, Aaron J, Krych, Nancy M, Cummings, and Diane L, Dahm

Subjects
Male, Reoperation, Kaplan-Meier Estimate, Patella, Middle Aged, Osteoarthritis, Knee, Radiography, Patellofemoral Joint, Postoperative Complications, Treatment Outcome, Humans, Female, Arthroplasty, Replacement, Knee, Retrospective Studies
Abstract

The purpose of this study was to evaluate the effect of preoperative patella alta on clinical outcomes, survivorship, and complication and reoperation rates on patellofemoral arthroplasty (PFA).All patients who underwent PFA for isolated patellofemoral arthritis by a single surgeon at our institution were identified. Preoperative radiographs were measured by two independent observers for patellar height using the Caton Deschamps (CD), Insall-Salvati (IS), and Blackburne-Peele (BP) methods. Patients were classified as either "patella alta" or "non-patella alta" for all three measurement methods. Clinical scores including KSS Pain, KSS Function, and Tegner Activity Scores were collected pre- and post-operatively. Failure was defined as conversion to total knee arthroplasty (TKA). Clinical outcomes and survivorship were compared between patients with "patella alta" and "non-patella alta" height measurements.There were 119 patients with 153 knees (86% female) included in the study with a mean age of 55.8 years. Outcome scores improved from pre-operative to post-operative for both patella alta and non-patella alta patients for Tegner, KSS pain and KSS function scores. The mean change in Tegner scores for patella alta and non-patella alta patients were not significantly different for CD (p = 0.24), IS (p = 0.25) or BP measurements (p = 0.39). The mean change in KSS pain scores between groups were not significantly different for CD (p = 0.33) or IS measurements (p = 0.22), but was improved more significantly in patella alta patients vs non-patella alta patients (21.2 and 14.4; p = 0.02) for BP measurement. The mean change in KSS function scores between groups was not significantly different for CD (p = 0.61) IS (p = 0.90) or BP measurements (p = 0.79). The overall survivorship from conversion to total knee arthroplasty (TKA) was 94.1% at a mean follow-up time of 5.0 (SD 2.6) years. There were no significant differences in survivorship from TKA between patella alta and non-patella alta groups (CD: p = 0.72, IS: p = 0.63, BP: p = 0.66).This study suggests that there are no significant differences in clinical outcome scores or survivorship from TKA between patella alta and non-patella alta patients who underwent onlay design PFA. Both patella alta and non-patella alta patients demonstrated excellent improvement in outcome scores from pre-operative to post-operative.IV.

Published
2019

109. Observation of the Decay D0→K−π+e+e−

Author

C. Bünger, Stephen Sekula, A. Oyanguren, A. Jawahery, C. Bozzi, J. Chauveau, F. De Mori, K. Honscheid, E. A. Kozyrev, N. Tasneem, Heiko Lacker, Aidan Randle-Conde, R. J. Barlow, G. R. Bonneaud, R. Cenci, C. Touramanis, A. Zallo, Florian Urs Bernlochner, G. Cibinetto, B. Bhuyan, F. Palombo, T. Lueck, B. G. Fulsom, E. P. Solodov, T. S. Miyashita, S. Bettarini, S. Prell, O. Grünberg, D. W. G. S. Leith, Maurizio Biasini, M. Posocco, G. Calderini, James H Cochran, J. L. Ritchie, I. M. Peruzzi, R. Gorodeisky, D. A. Roberts, S. I. Serednyakov, A. G. Denig, K. R. Schubert, Owen Rosser Long, H. A. Neal, G. Casarosa, A. M. Rossi, F. Bianchi, A. Lusiani, V. P. Druzhinin, V. Poireau, T. S. Mattison, V. B. Golubev, G. Wormser, J. A. Ernst, W. Gradl, A. Palano, T. Schroeder, A. Hafner, Joseph Izen, L. Lanceri, S. Emery, R. Y. So, M. Bellis, S. Dittrich, C. Hearty, P. Ongmongkolkul, C. Hast, D. J. Lange, G. Piredda, W. J. Wisniewski, E. M. T. Puccio, A. R. Buzykaev, M. S. Alam, M. T. Graham, Eleonora Luppi, M. Piccolo, A. P. Onuchin, A. Beaulieu, S. Martellotti, M. Carpinelli, L. M. Cremaldi, J. M. Roney, L. Sun, T. J. Gershon, B. Echenard, James R. Wilson, G. Batignani, Z. C. Huard, W. Panduro Vazquez, G. J. King, S. Luitz, D. Bernard, P. C. Kim, M. V. Purohit, D. J. Summers, P. Patteri, D. G. Hitlin, W. R. Innes, R. F. Schwitters, J. Va’vra, E. A. Kravchenko, J. Albert, A. Filippi, Elisa Manoni, Colin Jessop, R. Prepost, D. Aston, J. G. Smith, R. C. Field, E. Ben-Haim, Adrian John Bevan, F. Forti, W. S. Lockman, Crisostomo Sciacca, F. Anulli, W. Dunwoodie, R. Cowan, J. Dorfan, J. J. Walsh, Y. Li, A. M. Eisner, I. M. Nugent, Alessandro Gaz, A. Calcaterra, i> ar, B. G. Pushpawela, Tim Adye, R. Sacco, D. N. Brown, A. M. Lutz, R. D. Kass, M. Bomben, R. J. Sobie, G. Finocchiaro, Sw. Banerjee, C. H. Cheng, T. E. Latham, S. H. Robertson, L. Vitale, F. Di Lodovico, G. Eigen, R. de Sangro, S. Passaggio, S. L. Wu, R. Faccini, F. Ferrarotto, A. J. Lankford, F. Martinez-Vidal, C. Cartaro, Dominik Müller, J. P. Lees, D. J. Payne, Herbert Koch, F. Le Diberder, G. D. Lafferty, N. Arnaud, R. Kowalewski, M. Rotondo, F. F. Wilson, M. R. Convery, A. J.S. Smith, Yu. I. Skovpen, G. De Nardo, Abner Soffer, D. S. Chao, B. Oberhof, M. Röhrken, Simon Akar, Yu G. Kolomensky, K. Griessinger, K. Yu. Todyshev, B. N. Ratcliff, M. Davier, V. Santoro, B. T. Meadows, G. Vasseur, A. Roodman, G. A. Cowan, Douglas Wright, K. T. Flood, G. Raven, R. Godang, R. M. Seddon, M. D. Sokoloff, E. Fioravanti, L. Zani, P. R. Burchat, E. Paoloni, R. Stroili, Roland Waldi, P. Taras, Alessandro Pilloni, F. Ferroni, D. R. Peimer, Roberto Calabrese, D. B. MacFarlane, D. Gamba, M. Rama, Paul Fraser Harrison, J. A. McKenna, Ju-Young Kim, Stephen Robert Wagner, Hamad Ahmed, J. Ocariz, M. K. Sullivan, N. Guttman, M. Heß, J. W. Gary, J. P. Coleman, E. Grauges, Mario Giorgi, R. Cheaib, G. Marchiori, E. Gabathuler, F. C. Porter, span> B, F. Simonetto, J. M. LoSecco, B. Dey, C. H. Chen, X. C. Lou, S. M. Spanier, Martino Margoni, M. Chrzaszcz, C. Voß, Vladimir Blinov, D. Bettoni, Andrei Gritsan, I. Garzia, D. E. Hutchcroft, C. Patrignani, G. Rizzo, V. Tisserand, T. Leddig, M. Verderi, U. Mallik, N. Neri, M. Fritsch, Gabriele Simi, C. L. Davis, and M. Ebert

Subjects
Physics, Particle physics, Annihilation, Branching fraction, 0103 physical sciences, General Physics and Astronomy, Resonance, Invariant mass, 010306 general physics, 01 natural sciences, Energy (signal processing), Standard Model
Abstract

We report the observation of the rare charm decay D^{0}→K^{-}π^{+}e^{+}e^{-}, based on 468 fb^{-1} of e^{+}e^{-} annihilation data collected at or close to the center-of-mass energy of the ϒ(4S) resonance with the BABAR detector at the SLAC National Accelerator Laboratory. We find the branching fraction in the invariant mass range 0.675

Published
2019
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110. [Image of the month: Intra-uterine wire]

Author

D, Bernard, V, Goffioul, and O, Wéry

Subjects
Uterine Diseases, Equipment and Supplies, Humans, Female, Hysteroscopy, Infertility, Female
Published
2019

111. Osteochondritis dissecans lesions of the capitellum in overhead athletes: a review of current evidence and proposed treatment algorithm

Author

Joaquin Sanchez-Sotelo, Christopher L. Camp, Aaron J. Krych, Shawn W. O'Driscoll, Mark E. Morrey, Christopher D. Bernard, and Anthony L. Logli

Subjects
030222 orthopedics, medicine.medical_specialty, Injuries in Overhead Athletes (J Dines and C Camp, section editors), Sports medicine, business.industry, 030229 sport sciences, medicine.disease, Osteochondritis dissecans, Lesion, Cartilage restoration, 03 medical and health sciences, 0302 clinical medicine, Systematic review, Orthopedic surgery, medicine, Overhead (computing), Orthopedics and Sports Medicine, Overhead athletes, medicine.symptom, business, Algorithm
Abstract

PURPOSE OF THE REVIEW: To review the most recent literature on osteochondritis dissecans (OCD) lesions of the capitellum in overhead athletes and describe a treatment algorithm based on current best evidence and surgeon experience. RECENT FINDINGS: Recent research has included larger cohort studies with longer follow-up as well as quality systematic reviews and meta-analyses. These studies have focused on understanding how lesion characteristics such as size, location, and appearance on advanced imaging can predict treatment success. Current literature continues to support nonoperative management for stable lesions. Operative intervention is generally required for unstable lesions and treatment strategies are largely dictated by lesion size and location: debridement or reparative techniques for small lesions while larger lesions or those in high-stress locations are better served by bone and/or cartilage restoration procedures. There has been a rising interest in the use of allograft materials and cell-based therapies. SUMMARY: Overhead athletes are uniquely predisposed to capitellar OCD due to the nature of forces applied to the radiocapitellar joint during repeated activity in the overhead position. Despite improvements in operative techniques, successful use of alternative graft materials, and a better understanding of how lesion characteristics influence results, there is still much to learn about this challenging disorder. Future research should focus on comparing operative techniques, refining their indications, and further developing a reliable treatment algorithm that best serves the overhead athlete.

Published
2019

112. Search for a Stable Six-Quark State at BABAR

Author

J. Chauveau, F. De Mori, Heiko Lacker, J. L. Ritchie, Yu. I. Skovpen, S. I. Serednyakov, S. Bettarini, G. Finocchiaro, R. Y. So, K. R. Schubert, J. Dorfan, F. F. Wilson, R. Gorodeisky, D. A. Roberts, Roberto Calabrese, B. Oberhof, B. Bhuyan, K. Yu. Todyshev, P. Taras, A. Hafner, Giulia Casarosa, G. Wormser, V. B. Golubev, E. M. T. Puccio, J. Ocariz, J. W. Gary, D. B. MacFarlane, G. Rizzo, M. Rama, E. Grauges, Stefan Spanier, S. Prell, James H Cochran, N. Tasneem, Mario Giorgi, R. F. Schwitters, A. Lusiani, H. A. Neal, A. Calcaterra, R. Cheaib, W. R. Innes, A. Palano, V. P. Druzhinin, Randall Sobie, T. Schroeder, C. H. Cheng, Maurizio Biasini, D. Bettoni, C. Cartaro, Aidan Randle-Conde, Abner Soffer, R. Cenci, I. M. Peruzzi, B. Echenard, G. R. Bonneaud, Tim Adye, David Hutchcroft, J. M. LoSecco, D. Bernard, P. C. Kim, A. Zallo, R. de Sangro, B. Dey, R. D. Kass, Owen Rosser Long, S. L. Wu, S. Luitz, P. Patteri, J. J. Walsh, J. Va’vra, W. J. Wisniewski, R. Stroili, A. G. Denig, J. P. Lees, R. Godang, M. T. Graham, Eleonora Luppi, G. J. King, D. N. Brown, I. Garzia, A. R. Buzykaev, M. S. Alam, A. P. Onuchin, L. Sun, R. Sacco, David Lange, W. Dunwoodie, Y. Li, C. Patrignani, B. G. Fulsom, V. Tisserand, J. A. McKenna, Adrian John Bevan, A. Beaulieu, B. G. Pushpawela, Andrei Gritsan, A. M. Lutz, E. Paoloni, N. Arnaud, Colin Jessop, R. Prepost, G. D. Lafferty, Douglas Wright, V. Santoro, L. Zani, R. Kowalewski, L. M. Cremaldi, J. A. Ernst, W. Gradl, S. Passaggio, L. Lanceri, M. R. Convery, C. Bünger, Florian Urs Bernlochner, James R. Wilson, F. Palombo, T. Lueck, A. J.S. Smith, E. Gabathuler, A. Jawahery, F. C. Porter, M. Heß, Martino Margoni, Simon Akar, D. G. Hitlin, G. Cibinetto, G. Vasseur, K. T. Flood, E. A. Kozyrev, A. Filippi, Alessandro Pilloni, D. R. Peimer, B. N. Ratcliff, Hamad Ahmed, B. T. Meadows, G. Raven, M. V. Purohit, R. C. Field, F. Forti, M. Chrzaszcz, M. D. Sokoloff, Nicola Neri, P. R. Burchat, R. Cowan, C. Voß, J. Albert, G. Eigen, D. W. G. S. 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P., Poireau, V., Tisserand, V., Grauges, E., Palano, A., Eigen, G., Brown, D. N., Kolomensky, Yu. G., Fritsch, M., Koch, H., Schroeder, T., Hearty, C., Mattison, T. S., Mckenna, J. A., So, R. Y., Blinov, V. E., Buzykaev, A. R., Druzhinin, V. P., Golubev, V. B., Kozyrev, E. A., Kravchenko, E. A., Onuchin, A. P., Serednyakov, S. I., Skovpen, Y. I., Solodov, E. P., Todyshev, K. Y., Lankford, A. J., Gary, J. W., Long, O., Eisner, A. M., Lockman, W. S., Panduro Vazquez, W., Chao, D. S., Cheng, C. H., Echenard, B., Flood, K. T., Hitlin, D. G., Kim, J., Li, Y., Miyashita, T. S., Ongmongkolkul, P., Porter, F. C., Rohrken, M., Huard, Z., Meadows, B. T., Pushpawela, B. G., Sokoloff, M. D., Sun, L., Smith, J. G., Wagner, S. R., Bernard, D., Verderi, M., Bettoni, D., Bozzi, C., Calabrese, R., Cibinetto, G., Fioravanti, E., Garzia, I., Luppi, E., Santoro, V., Calcaterra, A., De Sangro, R., Finocchiaro, G., Martellotti, S., Patteri, P., Peruzzi, I. M., Piccolo, M., Rotondo, M., Zallo, A., Passaggio, S., Patrignani, C., Lacker, H. M., Bhuyan, B., Mallik, U., Chen, C., Cochran, J., Prell, S., Gritsan, A. V., Arnaud, N., Davier, M., Le Diberder, F., Lutz, A. M., Wormser, G., Lange, D. J., Wright, D. M., Coleman, J. P., Gabathuler, E., Hutchcroft, D. E., Payne, D. J., Touramanis, C., Bevan, A. J., Di Lodovico, F., Sacco, R., Cowan, G., Banerjee, S., Davis, C. L., Denig, A. G., Gradl, W., Griessinger, K., Hafner, A., Schubert, K. R., Barlow, R. J., Lafferty, G. D., Cenci, R., Jawahery, A., Roberts, D. A., Cowan, R., Robertson, S. H., Seddon, R. M., Dey, B., Neri, N., Palombo, F., Cheaib, R., Cremaldi, L., Godang, R., Summers, D. J., Taras, P., De Nardo, G., Sciacca, C., Raven, G., Jessop, C. P., Losecco, J. M., Honscheid, K., Kass, R., Gaz, A., Margoni, M., Posocco, M., Simi, G., Simonetto, F., Stroili, R., Akar, S., Ben-Haim, E., Bomben, M., Bonneaud, G. R., Calderini, G., Chauveau, J., Marchiori, G., Ocariz, J., Biasini, M., Manoni, E., Rossi, A., Batignani, G., Bettarini, S., Carpinelli, M., Casarosa, G., Chrzaszcz, M., Forti, F., Giorgi, M. A., Lusiani, A., Oberhof, B., Paoloni, E., Rama, M., Rizzo, G., Walsh, J. J., Zani, L., Smith, A. J. S., Anulli, F., Faccini, R., Ferrarotto, F., Ferroni, F., Pilloni, A., Piredda, G., Bunger, C., Dittrich, S., Grunberg, O., Hess, M., Leddig, T., Voss, C., Waldi, R., Adye, T., Wilson, F. F., Emery, S., Vasseur, G., Aston, D., Cartaro, C., Convery, M. R., Dorfan, J., Dunwoodie, W., Ebert, M., Field, R. C., Fulsom, B. G., Graham, M. T., Hast, C., Innes, W. R., Kim, P., Leith, D. W. G. S., Luitz, S., Macfarlane, D. B., Muller, D. R., Neal, H., Ratcliff, B. N., Roodman, A., Sullivan, M. K., Va'Vra, J., Wisniewski, W. J., Purohit, M. V., Wilson, J. R., Randle-Conde, A., Sekula, S. J., Ahmed, H., Bellis, M., Burchat, P. R., Puccio, E. M. T., Alam, M. S., Ernst, J. A., Gorodeisky, R., Guttman, N., Peimer, D. R., Soffer, A., Spanier, S. M., Ritchie, J. L., Schwitters, R. F., Izen, J. M., Lou, X. C., Bianchi, F., De Mori, F., Filippi, A., Gamba, D., Lanceri, L., Vitale, L., Martinez-Vidal, F., Oyanguren, A., Albert, J., Beaulieu, A., Bernlochner, F. U., King, G. J., Kowalewski, R., Lueck, T., Nugent, I. M., Roney, J. M., Sobie, R. J., Tasneem, N., Gershon, T. J., Harrison, P. F., Latham, T. E., Prepost, R., Wu, S. L., Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Laboratoire de l'Accélérateur Linéaire (LAL), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), Laboratoire de Physique Nucléaire et de Hautes Énergies (LPNHE (UMR_7585)), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris Diderot - Paris 7 (UPD7)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPP), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, BaBar, Lees J.P., Poireau V., Tisserand V., Grauges E., Palano A., Eigen G., Brown D.N., Kolomensky Yu.G., Fritsch M., Koch H., Schroeder T., Hearty C., Mattison T.S., McKenna J.A., So R.Y., Blinov V.E., Buzykaev A.R., Druzhinin V.P., Golubev V.B., Kozyrev E.A., Kravchenko E.A., Onuchin A.P., Serednyakov S.I., Skovpen Y.I., Solodov E.P., Todyshev K.Y., Lankford A.J., Gary J.W., Long O., Eisner A.M., Lockman W.S., Panduro Vazquez W., Chao D.S., Cheng C.H., Echenard B., Flood K.T., Hitlin D.G., Kim J., Li Y., Miyashita T.S., Ongmongkolkul P., Porter F.C., Rohrken M., Huard Z., Meadows B.T., Pushpawela B.G., Sokoloff M.D., Sun L., Smith J.G., Wagner S.R., Bernard D., Verderi M., Bettoni D., Bozzi C., Calabrese R., Cibinetto G., Fioravanti E., Garzia I., Luppi E., Santoro V., Calcaterra A., De Sangro R., Finocchiaro G., Martellotti S., Patteri P., Peruzzi I.M., Piccolo M., Rotondo M., Zallo A., Passaggio S., Patrignani C., Lacker H.M., Bhuyan B., Mallik U., Chen C., Cochran J., Prell S., Gritsan A.V., Arnaud N., Davier M., Le Diberder F., Lutz A.M., Wormser G., Lange D.J., Wright D.M., Coleman J.P., Gabathuler E., Hutchcroft D.E., Payne D.J., Touramanis C., Bevan A.J., Di Lodovico F., Sacco R., Cowan G., Banerjee S., Davis C.L., Denig A.G., Gradl W., Griessinger K., Hafner A., Schubert K.R., Barlow R.J., Lafferty G.D., Cenci R., Jawahery A., Roberts D.A., Cowan R., Robertson S.H., Seddon R.M., Dey B., Neri N., Palombo F., Cheaib R., Cremaldi L., Godang R., Summers D.J., Taras P., De Nardo G., Sciacca C., Raven G., Jessop C.P., Losecco J.M., Honscheid K., Kass R., Gaz A., Margoni M., Posocco M., Simi G., Simonetto F., Stroili R., Akar S., Ben-Haim E., Bomben M., Bonneaud G.R., Calderini G., Chauveau J., Marchiori G., Ocariz J., Biasini M., Manoni E., Rossi A., Batignani G., Bettarini S., Carpinelli M., Casarosa G., Chrzaszcz M., Forti F., Giorgi M.A., Lusiani A., Oberhof B., Paoloni E., Rama M., Rizzo G., Walsh J.J., Zani L., Smith A.J.S., Anulli F., Faccini R., Ferrarotto F., Ferroni F., Pilloni A., Piredda G., Bunger C., Dittrich S., Grunberg O., Hess M., Leddig T., Voss C., Waldi R., Adye T., Wilson F.F., Emery S., Vasseur G., Aston D., Cartaro C., Convery M.R., Dorfan J., Dunwoodie W., Ebert M., Field R.C., Fulsom B.G., Graham M.T., Hast C., Innes W.R., Kim P., Leith D.W.G.S., Luitz S., Macfarlane D.B., Muller D.R., Neal H., Ratcliff B.N., Roodman A., Sullivan M.K., Va'Vra J., Wisniewski W.J., Purohit M.V., Wilson J.R., Randle-Conde A., Sekula S.J., Ahmed H., Bellis M., Burchat P.R., Puccio E.M.T., Alam M.S., Ernst J.A., Gorodeisky R., Guttman N., Peimer D.R., Soffer A., Spanier S.M., Ritchie J.L., Schwitters R.F., Izen J.M., Lou X.C., Bianchi F., De Mori F., Filippi A., Gamba D., Lanceri L., Vitale L., Martinez-Vidal F., Oyanguren A., Albert J., Beaulieu A., Bernlochner F.U., King G.J., Kowalewski R., Lueck T., Nugent I.M., Roney J.M., Sobie R.J., Tasneem N., Gershon T.J., Harrison P.F., Latham T.E., Prepost R., Wu S.L., Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Skovpen, Yu. I., Todyshev, K. Yu., Röhrken, M., de Sangro, R., Banerjee, Sw., Bünger, C., Grünberg, O., Heß, M., Voß, C., Va’Vra, J., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Sorbonne Université (SU)-Centre National de la Recherche Scientifique (CNRS), Département de Physique des Particules (ex SPP) (DPhP), Massachusetts Institute of Technology. Laboratory for Nuclear Science, and Cowan, Ray F

Subjects
Kjerne- og elementærpartikkelfysikk: 431 [VDP], branching ratio: upper limit, Electron–positron annihilation, Bound state, General Physics and Astronomy, BaBar experiment, Quarks, Upsilon(10355): rare decay, Upsilon(10355): electroproduction, Upsilon(10020): branching ratio, particle: exotic, upsilon mesons: hadronic decay, 01 natural sciences, decay, High Energy Physics - Experiment, High Energy Physics - Experiment (hep-ex), Upsilon(10020): electroproduction, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Physic, QC, QB, Exotic particles, Physics, new physics: search for, Settore FIS/01 - Fisica Sperimentale, electron positron: colliding beams, detector, limits, decay, Nuclear and elementary particle physics: 431 [VDP], Particles, Dark matter (Astronomy), Confidence level, baryon: dark matter, Upsilon(10020): rare decay, Branching fraction, Matèria fosca (Astronomia), Quark, Particle physics, Dark matter, FOS: Physical sciences, Lambda: pair production, electron positron: annihilation, Partícules (Matèria), NO, Physics and Astronomy (all), BABAR experiment, 0103 physical sciences, Atomic physic, Upsilon(10355): branching ratio, 010306 general physics, detector, dark matter: mass, State (functional analysis), stability, SLAC PEP Stor, HEP, A-stable, BaBar, Elementary Particles and Fields, High Energy Physics::Experiment, limits, experimental results
Abstract

Recent investigations have suggested that the six-quark combination uuddss could be a deeply bound state (S) that has eluded detection so far, and a potential dark matter candidate. We report the first search for a stable, doubly strange six-quark state in Upsilon -> S anti-Lambda anti-Lambda decays based on a sample of 90 million Upsilon(2S) and 110 million Upsilon(3S) decays collected by the BABAR experiment. No signal is observed, and 90% confidence level limits on the combined Upsilon(2S,3S) -> S anti-Lambda anti-Lambda branching fraction in the range (1.2-1.4)x10^-7 are derived for m_S < 2.05 GeV. These bounds set stringent limits on the existence of such exotic particles., 7 pages, 4 figures, published version

Published
2019
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113. Study of the reactions e+e−→π+π−π0π0π0 and π+π−π0π0η at center-of-mass energies from threshold to 4.35 GeV using initial-state radiation

Author

J. P. Lees, V. Poireau, V. Tisserand, E. Grauges, A. Palano, G. Eigen, D. N. Brown, Yu. G. Kolomensky, M. Fritsch, H. Koch, T. Schroeder, R. Cheaib, C. Hearty, T. S. Mattison, J. A. McKenna, R. Y. So, V. E. Blinov, A. R. Buzykaev, V. P. Druzhinin, V. B. Golubev, E. A. Kozyrev, E. A. Kravchenko, A. P. Onuchin, S. I. Serednyakov, Yu. I. Skovpen, E. P. Solodov, K. Yu. Todyshev, A. J. Lankford, B. Dey, J. W. Gary, O. Long, A. M. Eisner, W. S. Lockman, W. Panduro Vazquez, D. S. Chao, C. H. Cheng, B. Echenard, K. T. Flood, D. G. Hitlin, J. Kim, Y. Li, D. X. Lin, S. Middleton, T. S. Miyashita, P. Ongmongkolkul, J. Oyang, F. C. Porter, M. Röhrken, Z. Huard, B. T. Meadows, B. G. Pushpawela, M. D. Sokoloff, L. Sun, J. G. Smith, S. R. Wagner, D. Bernard, M. Verderi, D. Bettoni, C. Bozzi, R. Calabrese, G. Cibinetto, E. Fioravanti, I. Garzia, E. Luppi, V. Santoro, A. Calcaterra, R. de Sangro, G. Finocchiaro, S. Martellotti, P. Patteri, I. M. Peruzzi, M. Piccolo, M. Rotondo, A. Zallo, S. Passaggio, C. Patrignani, B. J. Shuve, H. M. Lacker, B. Bhuyan, U. Mallik, C. Chen, J. Cochran, S. Prell, A. V. Gritsan, N. Arnaud, M. Davier, F. Le Diberder, A. M. Lutz, G. Wormser, D. J. Lange, D. M. Wright, J. P. Coleman, E. Gabathuler, D. E. Hutchcroft, D. J. Payne, C. Touramanis, A. J. Bevan, F. Di Lodovico, R. Sacco, G. Cowan, Sw. Banerjee, C. L. Davis, A. G. Denig, W. Gradl, K. Griessinger, A. Hafner, K. R. Schubert, R. J. Barlow, G. D. Lafferty, R. Cenci, A. Jawahery, D. A. Roberts, R. Cowan, S. H. Robertson, R. M. Seddon, N. Neri, F. Palombo, L. Cremaldi, R. Godang, D. J. Summers, P. Taras, G. De Nardo, C. Sciacca, G. Raven, C. P. Jessop, J. M. LoSecco, K. Honscheid, R. Kass, A. Gaz, M. Margoni, M. Posocco, G. Simi, F. Simonetto, R. Stroili, S. Akar, E. Ben-Haim, M. Bomben, G. R. Bonneaud, G. Calderini, J. Chauveau, G. Marchiori, J. Ocariz, M. Biasini, E. Manoni, A. Rossi, G. Batignani, S. Bettarini, M. Carpinelli, G. Casarosa, M. Chrzaszcz, F. Forti, M. A. Giorgi, A. Lusiani, B. Oberhof, E. Paoloni, M. Rama, G. Rizzo, J. J. Walsh, L. Zani, A. J. S. Smith, F. Anulli, R. Faccini, F. Ferrarotto, F. Ferroni, A. Pilloni, G. Piredda, C. Bünger, S. Dittrich, O. Grünberg, M. Heß, T. Leddig, C. Voß, R. Waldi, T. Adye, F. F. Wilson, S. Emery, G. Vasseur, D. Aston, C. Cartaro, M. R. Convery, J. Dorfan, W. Dunwoodie, M. Ebert, R. C. Field, B. G. Fulsom, M. T. Graham, C. Hast, W. R. Innes, P. Kim, D. W. G. S. Leith, S. Luitz, D. B. MacFarlane, D. R. Muller, H. Neal, B. N. Ratcliff, A. Roodman, M. K. Sullivan, J. Va’vra, W. J. Wisniewski, M. V. Purohit, J. R. Wilson, A. Randle-Conde, S. J. Sekula, H. Ahmed, N. Tasneem, M. Bellis, P. R. Burchat, E. M. T. Puccio, M. S. Alam, J. A. Ernst, R. Gorodeisky, N. Guttman, D. R. Peimer, A. Soffer, S. M. Spanier, J. L. Ritchie, R. F. Schwitters, J. M. Izen, X. C. Lou, F. Bianchi, F. De Mori, A. Filippi, D. Gamba, L. Lanceri, L. Vitale, F. Martinez-Vidal, A. Oyanguren, J. Albert, A. Beaulieu, F. U. Bernlochner, G. J. King, R. Kowalewski, T. Lueck, C. Miller, I. M. Nugent, J. M. Roney, R. J. Sobie, T. J. Gershon, P. F. Harrison, T. E. Latham, R. Prepost, and S. L. Wu

Subjects
Physics, Particle physics, 010308 nuclear & particles physics, Branching fraction, Electron–positron annihilation, Hadron, 7. Clean energy, 01 natural sciences, Omega, 0103 physical sciences, Mass spectrum, Pi, Intermediate state, Invariant mass, 010306 general physics
Abstract

We study the processes $e^+e^-\to 2(\pi^+\pi^-)\pi^0\pi^0\pi^0\gamma$ and $2(\pi^+\pi^-)\pi^0\pi^0\eta\gamma$ in which an energetic photon is radiated from the initial state. The data were collected with the \babar~ detector at SLAC. About 14\,000 and 4700 events, respectively, are selected from a data sample corresponding to an integrated luminosity of 469 fb^{-1}. The invariant mass of the hadronic final state defines the effective \epem center-of-mass energy. The center-of-mass energies range from threshold to 4.5 GeV. From the mass spectra, the first ever measurements of the $e^+e^-\to 2(\pi^+\pi^-)\pi^0\pi^0\pi^0$ and the $e^+e^-\to2(\pi^+\pi^-)\pi^0\pi^0\eta$ cross sections are performed. The contributions from $\omega\pi^+\pi^-\pi^0\pi^0$, $\eta2(\pi^+\pi^-)$, and other intermediate states are presented. We observe the $J/\psi$ and $\psi(2S)$ in most of these final states and measure the corresponding branching fractions, many of them for the first time.

Published
2018
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114. First Evidence for cos2β>0 and Resolution of the Cabibbo-Kobayashi-Maskawa Quark-Mixing Unitarity Triangle Ambiguity

Author

V. B. Golubev, K. Chilikin, L. Zani, J. R. Wilson, Iki Adachi, T. S. Miyashita, Doo Young Kim, A. Palano, S. Emery, M. Feindt, J. B. Kim, K. Griessinger, D. Epifanov, A. Hafner, W. R. Innes, David Hutchcroft, O. Long, R. Cenci, Brian Meadows, J. M. Izen, M. Bellis, Eleonora Guido, H. Neal, K. Inami, H. Ye, R. Kass, S. Martellotti, D. W G S Leith, G. Schnell, E. Won, R. Pestotnik, S. Nishida, A. Calcaterra, J. P. Coleman, J. A. McKenna, T. E. Browder, J. Ocariz, M. T. Graham, F. Ferroni, R. J. Sobie, A. Roodman, S. Pardi, J. L. Ritchie, Noritaka Shimizu, Vikas Bansal, Eleonora Luppi, A. Beaulieu, Tara Nanut, T. Uglov, A. V. Gritsan, G. Wormser, A. G. Denig, Vitaly Vorobyev, B. N. Ratcliff, R. Y. So, T. Kuhr, S. R. Wagner, G. De Nardo, H. M. Lacker, M. Starič, D. Liventsev, E. Nakano, Z. Drásal, V. Savinov, D. J. Summers, C. H. Cheng, H. Ono, D. A. Roberts, S. Al Said, T. Matsuda, A. J S Smith, D. S. Chao, Vladimir Zhulanov, R. Kroeger, E. Ben-Haim, M. E. Sevior, I. S. Lee, S. J. Sekula, C. Bozzi, R. Mizuk, M. Piccolo, F. Di Lodovico, S. Uno, R. Kulasiri, T. Schroeder, A. J. Lankford, S. Sandilya, R. Godang, P. Goldenzweig, P. Pakhlov, N. Tasneem, J. Albert, G.V. Russo, J. Cochran, Yu. G. Kolomensky, H. Hayashii, J. Libby, C. Van Hulse, T. A. Shibata, Z. C. Huard, U. Tamponi, S. Passaggio, H. Miyata, B. Pal, Y. B. Li, Marcin Chrzaszcz, F. Le Diberder, Michael Sokoloff, Ray Franklin Cowan, P. C. Kim, F. U. Bernlochner, P. Patteri, Prafulla Kumar Behera, W. S. Hou, I. M. Peruzzi, B. Oberhof, F. Simonetto, J. G. Shiu, G. J. King, V. Babu, K. T. Kim, J. K. Ahn, A. Soffer, M. Z. Wang, K. Kinoshita, B. Bhuyan, N. Guttman, H. Park, A. Bozek, S. H. Kim, J. Dorfan, M. Gelb, H. Koch, Vladimir Popov, A. Zallo, S. Jia, D. N. Brown, R. Stroili, R. Ayad, K. Cho, C. Hearty, M. Iwasaki, P. K. Resmi, Marcello Rotondo, B. G. Cheon, James E. Fast, A. Kuzmin, M. Ebert, T. K. Pedlar, T. Kumita, K. Yu. Todyshevx, F. Forti, Y. Choi, K. J. Nath, E. A. Kravchenko, L. Santelj, K. H. Kang, T. Leddig, Shih-Chang Lee, D. Matvienko, C. Voß, M. Bomben, J. Haba, Dominik Müller, X. C. Lou, C. Chen, G. Finocchiaro, C. Z. Yuan, Y. Jin, A. J. Schwartz, C. H. Wang, Alberto Lusiani, Semen Eidelman, E. Grauges, L. Vitale, S. Ogawa, A. Rossi, Y. Watanabe, J. P. Lees, A. Filippi, S. E. Vahsen, G. A. Cowan, C. Bünger, C. Sciacca, R. C. Field, Gabriele Simi, G. Eigen, R. Gorodeisky, F. Martinez-Vidal, J. J. Walsh, C. Schwanda, R. Itoh, H. Ahmed, D. Cinabro, Tao Luo, F. Tenchini, Th. Müller, G. Rizzo, Y. Sakai, D. Bernard, J. Chauveau, S. I. Serednyakov, F. Palombo, S. Korpar, E. Gabathuler, T. Ferber, Tagir Aushev, C. Cartaro, Y. Onuki, A. Jawahery, M. Nayak, G. Cibinetto, M. K. Sullivan, M. Margoni, Y. Guan, A. Oyanguren, E. Waheed, R. M. Seddon, Nicola Neri, J. W. Gary, V. Gaur, W. Panduro Vazquez, Y. Iwasaki, C. Touramanis, S. Luitz, K. R. Schubert, P. Taras, S. Hirose, D. J. Payne, E. Fioravanti, Y. Li, Y. J. Kwon, V.N. Zhilich, F. Ferrarotto, E. M. T. Puccio, G. B. Mohanty, P. L. Wang, B. Golob, T. Lueck, Roland Waldi, Biplab Dey, Peter Kodys, Fergus Wilson, M. A. Giorgi, E. Paoloni, A. Zupanc, F. De Mori, A. B. Kaliyar, P. F. Harrison, H. Kichimi, D. G. Hitlin, H. K. Moon, M. R. Convery, A. Chen, F. Bianchi, G. Piredda, O. Schneider, U. Mallik, R. Cheaib, Y. Yusa, Bingran Wang, M. Röhrken, K. Senyo, J. S. Lange, V. Santoro, W. J. Wisniewski, C. Hast, W. W. Jacobs, A. M. Eisner, I. M. Nugent, M. T. Hedges, M. Carpinelli, K. Miyabayashi, I. Badhrees, M. Posocco, B. G. Fulsom, R. F. Schwitters, G. Varner, R. Mussa, A. M. Lutz, K. T. Flood, G. Casarosa, Simon Akar, M. Takizawa, Pavel Krokovny, R. Calabrese, V. E. Blinov, A. R. Buzykaev, A. Ishikawa, G. Vasseur, Roger Barlow, Ju-Young Kim, Miriam Heß, Y. Seino, S. Bettarini, R. de Sangro, M. Nakao, M. Biasini, P. Križan, G. Raven, Alexander Bondar, D. Gamba, R. Sacco, L. Cremaldi, Yu. I. Skovpen, C. P. Shen, K. Honscheid, G. Calderini, Elisa Manoni, R. Kowalewski, N. Arnaud, V.E. Shebalin, M. Heck, L. K. Li, M. V. Purohit, S. Di Carlo, D. M. Asner, K. Hayasaka, Sw. Banerjee, Soumen Paul, M. Uchida, G. Pakhlova, P. R. Burchat, G. Karyan, V. Bhardwaj, C. L. Hsu, J. A. Ernst, S. L. Wu, P. Ongmongkolkul, H. Atmacan, D. B. Macfarlane, Alessandro Pilloni, K. K. Joo, S. Dittrich, D. R. Peimer, Kiyoshi Tanida, Timothy Gershon, D. Aston, L. Li Gioi, A. Garmash, F. Anulli, Z. Doležal, J. M. Roney, Yoshinobu Unno, S. Zakharov, M. Lubej, G. Inguglia, V. Zhukova, M. Merola, A. K. Giri, K. Sumisawa, S. M. Spanier, G. Batignani, M. Masuda, C. L. Davis, M. Fritsch, A. P. Onuchin, L. Sun, Adrian John Bevan, Somnath Choudhury, Leo Piilonen, O. Seon, Frank Simon, D. J. Lange, Matteo Rama, James G. Smith, V. P. Druzhinin, D. M. Wright, M. S. Alam, E. Solovieva, R. Prepost, N. Dash, M. Rozanska, D. Kotchetkov, T. Adye, A. Randle-Conde, T. Julius, M. Verderi, R. Faccini, V. Poireau, T. Sumiyoshi, J. M. Losecco, G. Marchiori, F. C. Porter, Martin Ritter, T. Sanuki, S. Cunliffe, J. Va'Vra, W. S. Lockman, M. Salehi, H. Aihara, George Lafferty, C. P. Jessop, T. Hara, T. Mori, Oliver Grünberg, G. R. Bonneaud, N. K. Nisar, I. Pavelkin, D. Bettoni, Z. P. Zhang, S. Prell, B. G. Pushpawela, A. Gaz, S. H. Robertson, L. Lanceri, Jyoti Prakash Biswal, B. Echenard, M. Davier, J. MacNaughton, A. M. Bakich, W. Dunwoodie, D. Červenkov, Rocky Bala Garg, T. S. Mattison, W. Gradl, E. P. Solodov, I. Garzia, Thomas Latham, C. Patrignani, V. Tisserand, and M. Bračko

Subjects
Quark, Physics, Particle physics, Unitarity, 010308 nuclear & particles physics, Electron–positron annihilation, Hadron, General Physics and Astronomy, Dalitz plot, 01 natural sciences, B-factory, KEKB, 0103 physical sciences, CP violation, 010306 general physics
Abstract

We present first evidence that the cosine of the CP-violating weak phase 2β is positive, and hence exclude trigonometric multifold solutions of the Cabibbo-Kobayashi-Maskawa (CKM) Unitarity Triangle using a time-dependent Dalitz plot analysis of B^{0}→D^{(*)}h^{0} with D→K_{S}^{0}π^{+}π^{-} decays, where h^{0}∈{π^{0},η,ω} denotes a light unflavored and neutral hadron. The measurement is performed combining the final data sets of the BABAR and Belle experiments collected at the ϒ(4S) resonance at the asymmetric-energy B factories PEP-II at SLAC and KEKB at KEK, respectively. The data samples contain (471±3)×10^{6}BB[over ¯] pairs recorded by the BABAR detector and (772±11)×10^{6}BB[over ¯] pairs recorded by the Belle detector. The results of the measurement are sin2β=0.80±0.14(stat)±0.06(syst)±0.03(model) and cos2β=0.91±0.22(stat)±0.09(syst)±0.07(model). The result for the direct measurement of the angle β of the CKM Unitarity Triangle is β=[22.5±4.4(stat)±1.2(syst)±0.6(model)]°. The measurement assumes no direct CP violation in B^{0}→D^{(*)}h^{0} decays. The quoted model uncertainties are due to the composition of the D^{0}→K_{S}^{0}π^{+}π^{-} decay amplitude model, which is newly established by performing a Dalitz plot amplitude analysis using a high-statistics e^{+}e^{-}→cc[over ¯] data sample. CP violation is observed in B^{0}→D^{(*)}h^{0} decays at the level of 5.1 standard deviations. The significance for cos2β>0 is 3.7 standard deviations. The trigonometric multifold solution π/2-β=(68.1±0.7)° is excluded at the level of 7.3 standard deviations. The measurement resolves an ambiguity in the determination of the apex of the CKM Unitarity Triangle.

Published
2018
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115. Does Internal Fixation for Unstable Osteochondritis Dissecans of the Skeletally Mature Knee Work? A Systematic Review

Author

Christopher L. Camp, Daniel B.F. Saris, Devin P. Leland, Aaron J. Krych, Norimasa Nakamura, and Christopher D. Bernard

Subjects
medicine.medical_specialty, Knee Joint, Radiography, medicine.medical_treatment, Bone Nails, 03 medical and health sciences, Fixation (surgical), 0302 clinical medicine, Cartilage transplantation, medicine, Internal fixation, Humans, Orthopedics and Sports Medicine, Kirschner wire, Orthopedic Procedures, Patient Reported Outcome Measures, Postoperative Period, 030222 orthopedics, business.industry, 030229 sport sciences, medicine.disease, Osteochondritis dissecans, Osteochondritis Dissecans, Surgery, Systematic review, Cartilage, Second-Look Surgery, Meta-analysis, business
Abstract

Purpose To report the rate of radiographic union, patient-reported outcomes, complications, and reoperations after internal fixation of unstable osteochondritis dissecans (OCD) in the skeletally mature knee. Methods A literature search was conducted according to Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines. Patients were included if they were skeletally mature and underwent internal fixation of an unstable OCD lesion of the knee. Risk of bias assessment was performed using the Methodological Index for Non-randomized Studies scoring system. Surgical technique, rate of union, patient-reported outcomes, complications, and reoperations were collected. Results Thirteen studies resulted in 148 patients (150 knees) for inclusion. Patient age ranged from 14 to 45 years. Numerous fixation procedures were used, including biodegradable devices (rods, pins, nails, and screws), metal screws, Kirschner wire, and autologous bone sticks. Overall, reported outcome measures were heterogeneous in nature. The rate of radiographic healing ranged from 67% to 100% across 6 studies. Improved subjective results and Hughston criteria on final follow-up ranged from 83% to 100% across 4 studies each. Mean postoperative Lysholm scores ranged from 42 to 98 in studies that reported them. Both complication and reoperation rates ranged from 0% to 44%. The most commonly performed reoperations were loose body excision and cartilage resurfacing procedures. Conclusions A variety of surgical techniques are available for treatment of unstable OCD lesions in the skeletally mature knee. In this systematic review, internal fixation of the native fragment showed acceptable rates of radiographic union and improved patient-reported outcomes relative to other techniques. Level of Evidence Level IV, systematic review of level III-IV studies.

Published
2018

116. Measurement of the γ*γ*→η′ transition form factor

Author

A. J S Smith, A. Randle-Conde, R. F. Schwitters, R. Cenci, R. de Sangro, M. K. Sullivan, Z. C. Huard, Gabriele Simi, J. R. Wilson, T. S. Miyashita, F. Le Diberder, C. H. Cheng, K. Yu Todyshev, V. E. Blinov, Marcin Chrzaszcz, M. Verderi, Eleonora Luppi, Yu. I. Skovpen, G. J. King, M. A. Giorgi, S. Passaggio, R. Faccini, J. M. Izen, Simon Akar, M. Bellis, T. Leddig, K. Honscheid, F. Forti, A. R. Buzykaev, C. Cartaro, D. J. Summers, A. M. Lutz, M. V. Purohit, F. Bianchi, J. W. Gary, P. Taras, A. Calcaterra, I. M. Nugent, R. Kowalewski, J. Dorfan, D. Gamba, D. J. Payne, X. C. Lou, N. Arnaud, J. P. Coleman, G. Eigen, M. Margoni, A. Soffer, R. Godang, E. Paoloni, M. Heß, D. S. Chao, G. Wormser, G. Batignani, M. R. Convery, D. B. Macfarlane, L. Lanceri, R. J. Sobie, A. Roodman, D. J. Lange, Alessandro Pilloni, D. R. Peimer, T. Schroeder, A. J. Lankford, D. Aston, W. Panduro Vazquez, Wu S. L., R. M. Seddon, E. P. Solodov, J. Chauveau, M. Posocco, S. Bettarini, R. Prepost, Y. B. Li, G. Piredda, F. Anulli, U. Mallik, M. Carpinelli, J. Va'Vra, E. Fioravanti, W. S. Lockman, Roland Waldi, So R. Y., L. Vitale, K. T. Flood, Ray Franklin Cowan, C. Chen, G. Raven, L. Zani, G. Vasseur, M. Piccolo, P. C. Kim, F. U. Bernlochner, T. Adye, J. M. Roney, S. M. Spanier, C. L. Davis, B. Echenard, M. Fritsch, K. Griessinger, G. Calderini, Alberto Lusiani, J. Ocariz, G. Casarosa, C. Hearty, Marcello Rotondo, S. Emery, M. T. Graham, B. Bhuyan, F. Simonetto, Timothy Gershon, R. Cheaib, Ju-Young Kim, M. Davier, A. Oyanguren, M. Bomben, Dominik Müller, F. Ferroni, Biplab Dey, W. J. Wisniewski, D. A. Roberts, F. Di Lodovico, Brian Meadows, E. Grauges, F. Martinez-Vidal, J. J. Walsh, Matteo Rama, A. V. Gritsan, D. Bernard, Fergus Wilson, A. G. Denig, B. N. Ratcliff, I. Garzia, James G. Smith, C. Sciacca, R. C. Field, H. Ahmed, C. Touramanis, D. N. Brown, S. Luitz, K. R. Schubert, S. I. Serednyakov, F. Palombo, V. Poireau, Thomas Latham, C. Patrignani, V. Tisserand, J. L. Ritchie, R. Calabrese, Nicola Neri, M. Biasini, T. Lueck, F. De Mori, J. M. Losecco, G. Marchiori, D. G. Hitlin, Elisa Manoni, F. C. Porter, Michael Sokoloff, J. Cochran, C. Bozzi, R. Gorodeisky, C. Hast, P. R. Burchat, G. A. Cowan, A. P. Onuchin, L. Sun, Sw. Banerjee, Yu. G. Kolomensky, P. Ongmongkolkul, E. Ben-Haim, J. A. Ernst, N. Tasneem, J. Albert, T. S. Mattison, N. Guttman, B. G. Fulsom, W. Gradl, Adrian John Bevan, F. Ferrarotto, E. M. T. Puccio, S. Dittrich, I. M. Peruzzi, M. Ebert, R. Stroili, A. Rossi, O. Long, C. Bünger, S. Martellotti, V. P. Druzhinin, D. M. Wright, G. De Nardo, H. M. Lacker, A. Jawahery, S. J. Sekula, G. Cibinetto, P. Patteri, W. Dunwoodie, M. S. Alam, H. Koch, E. A. Kozyrev, G. Finocchiaro, H. Neal, R. Kass, D. W G S Leith, A. Beaulieu, D. Bettoni, S. Prell, V. B. Golubev, B. G. Pushpawela, M. Röhrken, A. Gaz, R. Sacco, B. Oberhof, S. H. Robertson, A. Palano, E. A. Kravchenko, George Lafferty, C. P. Jessop, A. Filippi, G. Rizzo, A. Hafner, W. R. Innes, David Hutchcroft, Oliver Grünberg, G. R. Bonneaud, A. Zallo, C. Voß, J. A. McKenna, S. R. Wagner, E. Gabathuler, P. F. Harrison, A. M. Eisner, Roger Barlow, J. P. Lees, V. Santoro, and L. Cremaldi

Subjects
Physics, Range (particle radiation), 010308 nuclear & particles physics, Electron–positron annihilation, Form factor (quantum field theory), 01 natural sciences, 7. Clean energy, Measure (mathematics), law.invention, Luminosity, Nuclear physics, law, 0103 physical sciences, 010306 general physics, Collider
Abstract

We study the process e^+e^− → e^+e^−η′ in the double-tag mode and measure for the first time the γ⋆γ⋆ → η′ transition form factor F_η′(Q^2_1,Q^2_2) in the momentum-transfer range 2 < Q^2_1, Q^2_2 < 60 GeV^2. The analysis is based on a data sample corresponding to an integrated luminosity of around 469 fb^(-1) collected at the PEP-II e^+e^− collider with the BABAR detector at center-of-mass energies near 10.6 GeV.

Published
2018
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118. Incidence of Hip Dysplasia Diagnosis in Young Patients With Hip Pain: A Geographic Population Cohort Analysis

Author

Matthew D. LaPrade, Rena F. Hale, Bruce A. Levy, Aaron J. Krych, Robert T. Trousdale, Devin P. Leland, Heath P. Melugin, Christopher D. Bernard, and Rafael J. Sierra

Subjects
musculoskeletal diseases, medicine.medical_specialty, Pediatrics, Population, Geographic population, Hip dysplasia (canine), Article, 03 medical and health sciences, 0302 clinical medicine, Epidemiology, Medicine, Orthopedics and Sports Medicine, Hip pain, education, 030222 orthopedics, education.field_of_study, business.industry, Incidence (epidemiology), 030229 sport sciences, hip dysplasia, hip osteoarthritis, incidence, epidemiology, business, Cohort study, Early osteoarthritis
Abstract

Background: Hip dysplasia is a common source of hip pain and a known cause of early osteoarthritis of the hip. Purpose: To (1) define the population-based incidence of hip dysplasia diagnosis in young patients presenting with hip pain in a large geographically defined cohort, (2) analyze trends regarding presentation and diagnosis of hip dysplasia, and (3) report the rate and type of surgical interventions used to treat this population. Study Design: Cross-sectional study; Level of evidence, 3. Methods: A geographic epidemiological database was queried to identify patients aged 14 to 50 years with hip pain between the years 2000 and 2016. Patient medical records were analyzed, and demographic, imaging, clinical, and treatment history were recorded. Incidence trends were examined by use of linear regression with confidence intervals for age and calendar year. Results: Overall, 1893 patients were included. Of these, 156 patients (196 hips) had a diagnosis of hip dysplasia. The incidence of hip dysplasia diagnosis in patients who reported hip pain was 12.7 per 100,000 person-years. Patients with dysplasia had a mean age of 26.7 ± 9.8 years, while the highest age-adjusted incidence occurred at age 14 to 18 years in both male and female patients. Female patients had double the age-adjusted incidence of male patients (cases per 100,000 person-years: 16.8 [95% CI, 13.9-19.7] vs 8.7 [95% CI, 6.6-10.8]; P < .01). Of the patients who underwent magnetic resonance imaging, 77% had imaging consistent with labral pathology. Patients were treated with physical therapy (67%), intra-articular steroid injection (29%), hip arthroscopy (10%), and periacetabular osteotomy (9%). The use of hip arthroscopy significantly increased over time ( P < .01), whereas the use of steroid injection and periacetabular osteotomy did not ( P < .28 and P < .08, respectively). Conclusion: The incidence of hip dysplasia diagnosis in patients presenting with hip pain was 12.7 per 100,000 person-years. Female patients had twice the age-adjusted incidence of male patients, and the highest age-adjusted incidence occurred in the age range of 14 to 18 years in both sexes. The use of hip arthroscopy to treat patients with hip dysplasia significantly increased over time.

Published
2021
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119. Modeling Human TBX5 Haploinsufficiency Predicts Regulatory Networks for Congenital Heart Disease

Author

Tatyana Sukonnik, Fei Gu, Maximilian Haeussler, W. Patrick Devine, Reuben Thomas, Kavitha S. Rao, Michael H. Lai, Matthew L. Speir, William T. Pu, Irfan S. Kathiriya, Piyush Goyal, Bayardo I. Garay, Jonathan G. Seidman, Kai Li, Swetansu K. Hota, Andrew Blair, Benoit G. Bruneau, Henry Gong, Laure D. Bernard, Gunes A. Akgun, Holger Heyn, Lauren K. Wasson, Joshua M. Stuart, Giovanni Iacono, Kevin M. Hu, Brynn N. Akerberg, and Christine E. Seidman

Subjects
Transcription, Genetic, Gene Dosage, Gene regulatory network, Haploinsufficiency, single cell transcriptomics, Cardiovascular, Medical and Health Sciences, Congenital, Mice, 0302 clinical medicine, Models, disease modeling, Transcriptional regulation, 2.1 Biological and endogenous factors, Gene Regulatory Networks, Myocytes, Cardiac, MEF2C, Aetiology, Induced pluripotent stem cell, transcription factor, Heart Defects, Pediatric, Regulation of gene expression, 0303 health sciences, Heart development, MEF2 Transcription Factors, Cell Differentiation, Biological Sciences, cardiomyocyte differentiation, congenital heart disease, Heart Disease, Cardiac, Transcription, Heart Defects, Congenital, 1.1 Normal biological development and functioning, Heart Ventricles, Computational biology, Biology, Models, Biological, Gene dosage, Article, General Biochemistry, Genetics and Molecular Biology, 03 medical and health sciences, Genetic, Underpinning research, Genetics, Animals, Humans, Molecular Biology, Heart Disease - Coronary Heart Disease, Body Patterning, 030304 developmental biology, Myocytes, Human Genome, Cell Biology, Biological, Stem Cell Research, human induced pluripotent stem cells, Mutation, Congenital Structural Anomalies, gene regulation, T-Box Domain Proteins, 030217 neurology & neurosurgery, Developmental Biology
Abstract

Haploinsufficiency of transcriptional regulators causes human congenital heart disease (CHD); however, the underlying CHD gene regulatory network (GRN) imbalances are unknown. Here, we define transcriptional consequences of reduced dosage of the CHD transcription factor, TBX5, in individual cells during cardiomyocyte differentiation from human induced pluripotent stem cells (iPSCs). We discovered highly sensitive dysregulation of TBX5-dependent pathways-including lineage decisions and genes associated with heart development, cardiomyocyte function, and CHD genetics-in discrete subpopulations of cardiomyocytes. Spatial transcriptomic mapping revealed chamber-restricted expression for many TBX5-sensitive transcripts. GRN analysis indicated that cardiac network stability, including vulnerable CHD-linked nodes, is sensitive to TBX5 dosage. A GRN-predicted genetic interaction between Tbx5 and Mef2c, manifesting as ventricular septation defects, was validated in mice. These results demonstrate exquisite and diverse sensitivity to TBX5 dosage in heterogeneous subsets of iPSC-derived cardiomyocytes and predicts candidate GRNs for human CHDs, with implications for quantitative transcriptional regulation in disease.

Published
2021
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121. Serum IL-18 level, clinical symptoms and IL-18-607A/C polymorphism among chronic patients with schizophrenia in a Chinese Han population

Author

Jair C. Soares, Sarai Bhatti, Dachun Chen, Xiang Yang Zhang, Jessica L. Combs, Michael C. Davis, Shuping Tan, Jared D. Bernard, Yunlong Tan, Thomas R. Kosten, and Michelle Z. Malouta

Subjects
Adult, Male, China, medicine.medical_specialty, Endocrinology, Diabetes and Metabolism, Polymorphism, Single Nucleotide, Gastroenterology, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Gene Frequency, Internal medicine, Genotype, Ethnicity, medicine, Humans, Genetic Predisposition to Disease, Allele, Promoter Regions, Genetic, Allele frequency, Alleles, Biological Psychiatry, Aged, Psychiatric Status Rating Scales, Positive and Negative Syndrome Scale, Endocrine and Autonomic Systems, Interleukin-18, Case-control study, Middle Aged, 030227 psychiatry, Genotype frequency, Psychiatry and Mental health, Case-Control Studies, Schizophrenia, Female, Interleukin 18, Psychology, 030217 neurology & neurosurgery, Psychopathology, Clinical psychology
Abstract

Literature suggests that alterations in the inflammatory and immune systems are involved in the pathogenesis of schizophrenia. Specifically, patients diagnosed with schizophrenia exhibit increased IL-18, a pleiotropic proinflammatory cytokine in type 1 T-helper (Th1) responses. The functional 607A/C promoter polymorphism of the IL-18 gene is also associated with the psychopathology of this disorder. However, no current study has explored its role in the clinical symptoms of schizophrenia as mediated through IL-18 levels. We recruited 772 inpatients with schizophrenia and 775 healthy controls in a Han Chinese population and genotyped the IL-18-607A/C polymorphism. Patient psychopathology was assessed using the Positive and Negative Syndrome Scale (PANSS). Serum IL-18 levels were measured in 80 patients and 93 healthy controls. Our results showed that there were no significant differences in the distribution of the allele and genotype frequencies between the patients and controls. Both increased IL-18 serum level and the IL-18-607A/C polymorphism were positively associated with the PANSS general psychopathology subscore and the PANSS total score. Moreover, interaction of increased IL-18 serum level and the IL-18-607A/C polymorphism influenced the clinical psychopathological symptoms, indicating that association of IL-18 level with the PANSS general psychopathology subscale or the total scores was present only among patients carrying the C allele. We demonstrate an association between the IL-18-607A/C variant and clinical psychopathological symptoms in schizophrenia. Findings suggest that the association between higher IL-18 levels and clinical symptoms in schizophrenia is dependent on the IL-18-607A/C polymorphism.

Published
2016
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122. Recent advances in accurate neutronic calculation of GEN-3 LWR reactors

Author

Patrick Blaise, C. Vaglio, Alain Santamarina, J. F. Vidal, D. Bernard, and Pierre Leconte

Subjects
Physics, 020209 energy, Nuclear engineering, Nuclear data, 02 engineering and technology, Neutron reflector, Corium, Nuclear Energy and Engineering, 0202 electrical engineering, electronic engineering, information engineering, Neutron, Sensitivity (control systems), Uncertainty quantification, Core catcher, Uncertainty analysis
Abstract

New French GEN-III reactors are characterized by an improved safety (core catcher for corium, stainless-steel neutron reflector to minimize vessel embrittlement, permanent in-core instrumentation thanks to SPND, …). Moreover, the assembly central guide-tube can be replaced by a fuel pin and the First core is controlled through numerous 8% Gd burnable poison fuel pins. These new features harden the neutron spectrum and increase the neutronic calculation challenge. Therefore, a new calculation package APOLLO2.8 was developed, based on an efficient Method of Characteristics (MOC) and the new SHEM 281-group energy mesh that enables accurate resonant absorption prediction. The JEFF3.1.1 recent nuclear data library, which involves the feedback from Critical Experiments and LWR Post Irradiation Experiments, was used. The experimental validation of the APOLLO2.8/JEFF3.1.1 package allowed the Uncertainty Quantification associated with PWR design parameters. In order to meet target-accuracy required in specific GEN-III parameters, targeted integral experiments where achieved. To validate heavy neutron reflector the mock-up experiment PERLE was carried out in EOLE critical facility. PERLE allowed the calculation check of SS reflector-saving δ refl and the improvement of Fe cross-sections. Thanks to the large French experimental database, we determined reliable covariance matrices associated to JEFF3.1.1 evaluations, in order to perform the propagation of nuclear data uncertainties. Sensitivity/uncertainty analysis has shown that the predominant component on radial power map comes from the 238 U inelastic scattering cross-section. To reduce this 3% uncertainty component, we performed a 238 U( n,n ′) re-estimation, using relevant selected experiment benchmarks. This theoretical and experimental extensive work performed since 2003 allows a reliable prediction of the local flux and K eff (±200 pcm in 1 σ ) in large GEN-III reactors. The challenging pin-by-pin power prediction is today overcome, and 3D-stochastic TRIPOLI4 or 2D-deterministic APOLLO2.8 calculation uncertainty is decreased from prior ±8% to current ±2.6% value.

Published
2016
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123. Environmental risks: negotiating and drafting lease agreements.

Author

Street, Paul S. and Zaleha, D. Bernard

Subjects
Liability for environmental damages -- Cases, Commercial leases -- Cases, United States v. Monsanto (858 F.2d 160 (4th Cir. 1988)), Comprehensive Environmental Response, Compensation, and Liability Act of 1980
Published
1991

124. Anterior Shoulder Instability: Outcome of Initial Non-operative Treatment in 739 patients with a mean follow up of 15 years

Author

Lucas K. Keyt, Nicholas C. Duethman, Devin P. Leland, Aaron J. Krych, Christopher L. Camp, Christopher D. Bernard, and Diane L. Dahm

Subjects
medicine.medical_specialty, business.industry, Non operative treatment, medicine, Anterior instability, Orthopedics and Sports Medicine, Anterior shoulder, business, Instability, Article, Outcome (probability), Event (probability theory), Surgery
Abstract

Objectives: There remains a paucity of data describing the efficacy of non-operative treatment following an index anterior instability event. The purpose of this study was to describe the long-term outcomes of non-operative treatment following index anterior instability event, define the success rate of initial non-operative treatment for anterior shoulder instability, and describe factors that predict conversion to surgery after initial non-operative management to help guide surgical decision making in these patients. Methods: An established geographic database was utilized to identify patients under the age of 40 treated for anterior shoulder instability between 1994 and 2016. Patient demographics, comorbidities, injury characteristics, instability history, activity level, x-rays, advanced imaging, treatment course, and outcomes were evaluated. Patients treated non-operatively for the first 6 months following index instability event were analyzed to determine long-term outcomes, success rate of continued non-operative treatment, and factors associated with conversion to surgery. Results: 739 patients met criteria with an average follow-up of 190 months (range 0.13 to 490 months). Average age was 23.8, mean BMI was 25.6, 9.1% had a history of hyperlaxity, and 83.9% of instability events were due to trauma. 29.7% of patients had a Hill-Sachs lesion on index x-ray, and 6.3% had a bony Bankart. 198 shoulders went on to operative treatment (26.8%) with a mean time to surgery of 62.7 months following initial instability event. At final follow-up, 24.0% reported mild pain, 6.2% as moderate, 0.2% as severe. 13.8% of patients had evidence of glenohumeral arthritis on final follow-up x-rays compared to 1.6% on initial radiographs. Factors associated with conversion to surgery included 2 or more dislocations prior to first clinical evaluation (OR=1.75, pConclusion: The majority of patients less than 40 can be definitively treated non-operatively after an initial 6 month episode of non-operative treatment. A small proportion will report pain over the long-term and/or develop glenohumeral arthritis. Multiple factors upon initial evaluation were associated with future conversion to surgery including: increasing number of prior instability events, occupation, and degree of soft tissue injury on MRI.

Published
2020
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125. Validation of actinide nuclear data based on reactivity worth experiments in a MOX-LWR spectrum

Author

Pierre Tamagno, Pierre Leconte, D. Bernard, A. Gruel, Guillaume Truchet, Jean-Pascal Hudelot, J. Di Salvo, C. De Saint Jean, M. Antony, Benoit Geslot, Pascal Archier, and Romain Eschbach

Subjects
Materials science, 020209 energy, Nuclear engineering, Experimental data, Nuclear data, 02 engineering and technology, Actinide, 01 natural sciences, 010305 fluids & plasmas, Nuclear Energy and Engineering, 0103 physical sciences, 0202 electrical engineering, electronic engineering, information engineering, Reactivity (chemistry), Sensitivity (control systems), MOX fuel
Abstract

OSMOSE was a CEA/DOE collaborative experiment dedicated to the improvement of actinide nuclear data. Based on reactivity worth measurements of pure isotopic samples of various actinides from 232Th to 245Cm, it represents a unique set experimental data to validate evaluated nuclear data. This paper presents the analysis of the experiments conducted in a MOXLWR-type core configuration, with TRIPOLI-4® Monte-Carlo calculations. The comparison between calculated and measured reactivity worth shows a good agreement with JEFF-3.1.1 for all the actinides, except 241Am. The combination of the C/E results with the sensitivity coefficients and prior covariances in a re-estimation process suggests that some improvement is required on the 241Am (n,g), towards an increase of +6% of the JEFF-3.1.1 thermal capture cross section. Based on the same reestimation process, improvements in the nuclear data covariances are pointed out, with posterior uncertainties on the reactivity worth significantly reduced for 238Pu, 239Pu, 241Am, 237Np and 244+245Cm.

Published
2020
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126. ESBLE and MRSA carriage in cirrhotic patients: a retrospective study on clinical outcomes before and after liver transplantation

Author

Bianca Magro, D. Bernard, A. Mazzola, Mona Munteanu, Claire Goumard, C. Cammà, Olivier Scatton, V. Martinez, and Fabio Conti

Subjects
medicine.medical_specialty, Carriage, Hepatology, business.industry, medicine.medical_treatment, Internal medicine, Gastroenterology, Medicine, Retrospective cohort study, Liver transplantation, business
Published
2020
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127. Overview of the OECD-NEA Working Party on International Nuclear Data Evaluation Cooperation (WPEC)

Author

A. J. M. Plompen, Giuseppe Palmiotti, Vladimir Sobes, C. De Saint Jean, Ayman I. Hawari, Massimo Salvatores, Zhigang Ge, M. Fleming, Osamu Iwamoto, Hideo Harada, E. Dupont, D. Bernard, D. Brown, Morgan C. White, I. Kodeli, Arjan J. Koning, Fausto Malvagi, R.W. Mills, Mark B. Chadwick, Kenji Yokoyama, M. Herman, Gilles Noguere, and D. P. McNabb

Subjects
Engineering management, Software, Work (electrical), Application programming interface, Criticality, business.industry, Physics, QC1-999, Benchmark (surveying), Nuclear data, Thermal scattering, business, Quality assurance
Abstract

The OECD Nuclear Energy Agency (NEA) Working Party on International Nuclear Data Evaluation Cooperation (WPEC) was established in 1989 to facilitate collaboration in nuclear data activities. Over its thirty year history, different Subgroups have been created to address topics in nearly every aspect of nuclear data, including: experimental measurements, evaluation, validation, model development, quality assurance of databases and the development of software tools.WPEC has recently completed activities on fission yield evaluation, the general nuclear database structure (GNDS) to replace the ENDF-6 format, methods to provide feedback to evaluation, studies of specific capture cross sections, new methods in thermal scattering kernel evaluation and the Collaborative International Evaluated Library Organisation (CIELO) Pilot Project. Ongoing activities in GNDS application programming interface (API) development, methods for covariance evaluation and quality assurance in nuclear data validation using the International Criticality Safety Benchmark Evaluation Project (ICSBEP) database are complemented by the work of two Expert Groups that oversee the High-Priority Request List (HPRL) for Nuclear Data and the continuous development of the GNDS. New activities on the use of integral experiments for nuclear data validation and adjustment, as well as the use of the Shielding Integral Benchmark Archive and Database (SINBAD) for validation have begun and will be coordinated alongside future Subgroups.After three decades we will review the status of WPEC, how it integrates other collections and activities organised by the NEA and how it dovetails with the initiatives of the IAEA and other bodies to effectively coordinate international activities in nuclear data.

Published
2020
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129. Measurement of the spectral function for the τ−→K−KSντ decay

Author

G. J. King, D. B. Macfarlane, B. Bhuyan, J. Dorfan, Z. C. Huard, J. M. Izen, E. Grauges, M. Bellis, F. Martinez-Vidal, J. J. Walsh, V. B. Golubev, M. Röhrken, George Lafferty, C. P. Jessop, V. E. Blinov, Matteo Rama, A. V. Gritsan, A. Palano, James G. Smith, H. Neal, R. Kass, P. Ongmongkolkul, A. Hafner, W. R. Innes, David Hutchcroft, D. W G S Leith, D. Gamba, A. Beaulieu, J. Va'Vra, Oliver Grünberg, G. R. Bonneaud, W. S. Lockman, L. Lanceri, J. A. McKenna, S. R. Wagner, A. Calcaterra, B. Echenard, C. H. Cheng, R. M. Seddon, E. Fioravanti, A. G. Denig, B. N. Ratcliff, C. Bünger, M. Davier, V. P. Druzhinin, Ray Franklin Cowan, S. M. Spanier, A. Oyanguren, K. Griessinger, C. L. Davis, R. F. Schwitters, A. J S Smith, P. C. Kim, M. Posocco, K. T. Flood, R. Cheaib, A. Jawahery, N. Guttman, R. Stroili, M. Fritsch, F. U. Bernlochner, G. Cibinetto, J. Ocariz, M. T. Graham, D. M. Wright, M. S. Alam, Brian Meadows, Roland Waldi, So R. Y., F. De Mori, J. P. Lees, E. A. Kozyrev, W. J. Wisniewski, F. Ferroni, R. Gorodeisky, G. Vasseur, G. Wormser, F. Le Diberder, K. Yu Todyshev, B. G. Fulsom, C. Bozzi, Gabriele Simi, J. P. Coleman, R. Cenci, Ju-Young Kim, M. Bomben, F. Forti, R. Sacco, M. Margoni, C. Voß, Marcin Chrzaszcz, B. Oberhof, J. Cochran, A. M. Lutz, A. Zallo, Dominik Müller, T. Schroeder, A. J. Lankford, Yu. G. Kolomensky, G. Piredda, V. Santoro, U. Mallik, G. Batignani, M. Biasini, D. N. Brown, Y. B. Li, Michael Sokoloff, F. Ferrarotto, E. M. T. Puccio, M. Carpinelli, R. Godang, C. Sciacca, R. C. Field, H. Ahmed, T. Leddig, E. A. Kravchenko, D. J. Lange, R. Prepost, G. Casarosa, M. Ebert, P. R. Burchat, J. A. Ernst, L. Zani, A. Rossi, G. A. Cowan, S. Emery, Eleonora Luppi, C. Hearty, Marcello Rotondo, T. Adye, L. Vitale, X. C. Lou, S. Dittrich, J. L. Ritchie, O. Long, Wu S. L., D. Bernard, G. Eigen, A. Filippi, D. J. Summers, G. Rizzo, S. I. Serednyakov, F. Palombo, G. Calderini, A. Soffer, D. S. Chao, S. Martellotti, G. De Nardo, Alberto Lusiani, Nicola Neri, H. M. Lacker, C. Chen, Biplab Dey, N. Tasneem, J. Albert, Fergus Wilson, S. J. Sekula, C. Cartaro, I. M. Peruzzi, D. J. Payne, E. Ben-Haim, E. Paoloni, R. de Sangro, P. Patteri, Yu. I. Skovpen, K. Honscheid, J. W. Gary, P. Taras, M. Heß, R. Kowalewski, M. R. Convery, N. Arnaud, T. Lueck, D. G. Hitlin, J. Chauveau, C. Hast, Simon Akar, A. R. Buzykaev, H. Koch, S. Bettarini, G. Raven, G. Finocchiaro, M. Piccolo, F. Simonetto, C. Touramanis, S. Luitz, K. R. Schubert, R. J. Sobie, A. Roodman, W. Dunwoodie, T. S. Mattison, A. Randle-Conde, W. Gradl, M. K. Sullivan, M. Verderi, R. Faccini, V. Poireau, M. A. Giorgi, J. M. Losecco, G. Marchiori, F. C. Porter, F. Bianchi, I. M. Nugent, R. Calabrese, F. Di Lodovico, E. P. Solodov, Elisa Manoni, Sw. Banerjee, A. P. Onuchin, L. Sun, Adrian John Bevan, Alessandro Pilloni, I. Garzia, S. Passaggio, D. R. Peimer, Thomas Latham, C. Patrignani, V. Tisserand, D. Aston, F. Anulli, D. Bettoni, J. M. Roney, S. Prell, W. Panduro Vazquez, B. G. Pushpawela, A. Gaz, S. H. Robertson, M. V. Purohit, Timothy Gershon, D. A. Roberts, E. Gabathuler, P. F. Harrison, A. M. Eisner, L. Cremaldi, Roger Barlow, J. R. Wilson, and T. S. Miyashita

Subjects
S system, Physics, 010308 nuclear & particles physics, Branching fraction, Detector, 01 natural sciences, law.invention, Nuclear physics, law, 0103 physical sciences, Mass spectrum, Spectral function, 010306 general physics, Collider, Energy (signal processing)
Abstract

The decay τ^− → K^−K_Sν_τ has been studied using 430×10^6 e^+e^− → τ^+τ^− events produced at a center-of-mass energy around 10.6 GeV at the PEP-II collider and studied with the BABAR detector. The mass spectrum of the K^−K_S system has been measured and the spectral function has been obtained. The measured branching fraction B(τ^− → K^−K_Sν_τ) = (0.739 ± 0.011(stat) ± 0.020(syst)) × 10^(-3) is found to be in agreement with earlier measurements.

Published
2018
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130. Physical and behavioral adaptations to prevent overheating of the living wings of butterflies

Author

Julianne N. Pelaez, Gary D. Bernard, Richard A. Childers, Nanfang Yu, Cheng-Chia Tsai, Naomi E. Pierce, Crystal Ren, and Norman Nan Shi

Subjects
0106 biological sciences, 0301 basic medicine, Thermotolerance, animal structures, Infrared Rays, Behavioural ecology, Science, General Physics and Astronomy, FOS: Physical sciences, Biology, Bioenergetics, 010603 evolutionary biology, 01 natural sciences, Models, Biological, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Hemolymph, Solar Energy, Animals, Wings, Animal, Thermosensing, Physics - Biological Physics, lcsh:Science, Overheating (electricity), Insect wing, Multidisciplinary, Wing, Behavior, Animal, Temperature, General Chemistry, Animal behaviour, Adaptation, Physiological, Nanostructures, 030104 developmental biology, Biological Physics (physics.bio-ph), Thermodynamics, lcsh:Q, Biological system, Energy Metabolism, Butterflies, Entomology, Biological physics, Physics - Optics, Optics (physics.optics)
Abstract

The wings of Lepidoptera contain a matrix of living cells whose function requires appropriate temperatures. However, given their small thermal capacity, wings can overheat rapidly in the sun. Here we analyze butterfly wings across a wide range of simulated environmental conditions, and find that regions containing living cells are maintained at cooler temperatures. Diverse scale nanostructures and non-uniform cuticle thicknesses create a heterogeneous distribution of radiative cooling that selectively reduces the temperature of structures such as wing veins and androconial organs. These tissues are supplied by circulatory, neural and tracheal systems throughout the adult lifetime, indicating that the insect wing is a dynamic, living structure. Behavioral assays show that butterflies use wings to sense visible and infrared radiation, responding with specialized behaviors to prevent overheating of their wings. Our work highlights the physiological importance of wing temperature and how it is exquisitely regulated by structural and behavioral adaptations., Comment: 7 figures, accepted manuscript

Published
2018

131. Progress of Geant4 electromagnetic physics developments and applications

Author

Mihaly Novak, Samer Bakr, A. S. Howard, Ioanna Kyriakou, D. Bernard, Helmut Burkhardt, Farah Hariri, Marilena Bandieramonte, Soon Yung Jun, I. Semeniouk, Sebastien Incerti, Sabine Elles, Vladimir Grichine, D Sawkey, Jeremy M. C. Brown, Vladimir Ivanchenko, M. Maire, L. Urbán, O Kadri, Marie-Claude Bordage, Susanna Guatelli, Paolo Dondero, A. Mantero, Alexander Bagulya, Anton V. Sokolov, Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Centre de Recherches en Cancérologie de Toulouse (CRCT), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP/Laboratoire d'Annecy-le-Vieux de Physique des Particules), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Centre d'Etudes Nucléaires de Bordeaux Gradignan (CENBG), Université Sciences et Technologies - Bordeaux 1-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Geant4 Collaboration, and Laboratoire d'Annecy de Physique des Particules (LAPP)

Subjects
Physics, Free electron model, Large Hadron Collider, [PHYS.PHYS]Physics [physics]/Physics [physics], 010308 nuclear & particles physics, Scattering, QC1-999, Bremsstrahlung, Electron, Photoelectric effect, 01 natural sciences, 030218 nuclear medicine & medical imaging, Computing and Computers, Nuclear physics, 03 medical and health sciences, 0302 clinical medicine, Positron, 0103 physical sciences, Nuclear Physics - Experiment, Electron scattering
Abstract

International audience; We report on developments of the Geant4 electromagnetic physics sub-libraries of Geant4 release 10.4 and beyond. Modifications are introduced to the models of photoelectric effect, bremsstrahlung, gamma conversion, single and multiple scattering. The theory-based Goudsmit-Saunderson model of electron/positron multiple scattering has been recently reviewed and a new improved version, providing the most accurate results for scattering of electrons and positrons, was made available. The updated interfaces, models and configurations have already been integrated into LHC applications and may be useful for any type of simulations

Published
2018
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132. A Photofission Delayed γ-ray Spectra Calculation Tool for the Conception of a Nuclear Material Characterization Facility

Author

L. Boucher, D. Bernard, O. Serot, E. Simon, and S. Plumeri

Subjects
Photon, Materials science, Fissile material, 010308 nuclear & particles physics, Noise (signal processing), Nuclear engineering, Physics, QC1-999, Photofission, Radioactive waste, Nuclear material, 01 natural sciences, Characterization (materials science), Decay Data, 0103 physical sciences, Electromagnetic shielding, Nuclear Material Characterization, Delayed γ, 010306 general physics, Photonic Interrogation, Photofission Yields
Abstract

The photon interrogation analysis is a nondestructive technique allowing to identify and quantify fissile materials in nuclear waste packages. This paper details an automatic procedure which has been developed to simulate the delayed γ-ray spectra for several actinide photofissions. This calculation tool will be helpful for the fine conception (collimation, shielding, noise background optimizations, etc.) and for the on-line analysis of such a facility.

Published
2018

133. The e-ASTROGAM gamma-ray space observatory for the multimessenger astronomy of the 2030s

Author

Koji Nakazawa, F. Longo, A. Brogna, Andrei M. Bykov, J. Peyré, J. M. Paredes, A. A. Zdziarski, M. Hernanz, D. de Martino, Paolo De Coppi, Irfan Kuvvetli, M. Roncadelli, I. Donnarumma, A. De Angelis, I. Grenier, B. Patricelli, Vincent Tatischeff, G. Piano, Marco Tavani, Elisa Bernardini, M. Pohl, S. Ciprini, Carl Budtz-Jørgensen, Marco Ajello, P. von Ballmoos, J. Kiener, D. J. Thompson, Philippe Laurent, A. Aboudan, Jürgen Knödlseder, P. Cumani, Miriam Lucio Martinez, Lorraine Hanlon, Stefan Funk, Michele Doro, Martino Marisaldi, J. E. Grove, R. Rando, Gabriele Ghisellini, R. M. Curado da Silva, A. A. Moiseev, V. Bonvicini, Fabrizio Tavecchio, Julie McEnery, Gottfried Kanbach, A. Argan, Mark D. Leising, Roland Diehl, O. Limousin, Andrea Bulgarelli, Manuela Mallamaci, M. Cardillo, M. Branchesi, Xin Wu, A. Morselli, Sandro Mereghetti, Mark Pearce, R. Turolla, G. Minervini, R. Walter, C. Hamadache, Dieter H. Hartmann, Valentina Fioretti, Piotr Orleanski, A. Vacchi, A. Ulyanov, G. Ambrosi, Karl Mannheim, Ferdinando Giordano, D. Bernard, N. M. Mazziotta, Riccardo Campana, Uwe Oberlack, Jordi Isern, M. Hayashida, Andreas Zoglauer, Claudio Labanti, den Herder, Jan-Willem A., Nikzad, Shouleh, Nakazawa, Kazuhiro, Centre de Sciences Nucléaires et de Sciences de la Matière (CSNSM), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet (LLR), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Observatoire de Paris, PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, e-ASTROGAM, FRA, Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112)), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Observatoire Midi-Pyrénées (OMP), Institut de Recherche pour le Développement (IRD)-Université Toulouse III - Paul Sabatier (UT3), Université de Toulouse (UT)-Université de Toulouse (UT)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Institut de Recherche pour le Développement (IRD)-Institut national des sciences de l'Univers (INSU - CNRS)-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Météo-France -Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Jan-Willem A. den Herder, Shouleh Nikzad, Kazuhiro Nakazawa, Tatischeff, V., De Angelis, A., Tavani, M., Grenier, I., Oberlack, U., Hanlon, L., Walter, R., Argan, A., Von Ballmoos, P., Bulgarelli, A., Donnarumma, I., Hernanz, M., Kuvvetli, I., Mallamaci, M., Pearce, M., Zdziarski, A., Aboudan, A., Ajello, M., Ambrosi, G., Bernard, D., Bernardini, E., Bonvicini, V., Brogna, A., Branchesi, M., Budtz-Jorgensen, C., Bykov, A., Campana, R., Cardillo, M., Ciprini, S., Coppi, P., Cumani, P., Curado Da Silva, R. M., De Martino, D., Diehl, R., Doro, M., Fioretti, V., Funk, S., Ghisellini, G., Grove, J. E., Giordano, F., Hamadache, C., Hartmann, D. H., Hayashida, M., Isern, J., Kanbach, G., Kiener, J., Knodlseder, J., Labanti, C., Laurent, P., Leising, M., Limousin, O., Longo, F., Mannheim, K., Marisaldi, M., Martinez, M., Mazziotta, N. M., Mcenery, J. E., Mereghetti, S., Minervini, G., Moiseev, A., Morselli, A., Nakazawa, K., Orleanski, P., Paredes, J. M., Patricelli, B., Peyre, J., Piano, G., Pohl, M., Rando, R., Roncadelli, M., Tavecchio, F., Thompson, D. J., Turolla, R., Ulyanov, A., Vacchi, A., Wu, X., Zoglauer, A., Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Observatoire de Paris, and PSL Research University (PSL)-PSL Research University (PSL)-Université Paris Diderot - Paris 7 (UPD7)

Subjects
Cherenkov Telescope Array, High-energy astrophysical phenomena, Compton and pair creation telescope, Gamma-ray astronomy, gamma-ray polarization, high-energy astrophysical phenomena, space mission, time-domain astronomy, energy resolution, 7. Clean energy, 01 natural sciences, Space mission, law.invention, IceCube, Einstein Telescope, law, Observatory, LIGO, 010303 astronomy & astrophysics, KM3NeT, Physics, High Energy Astrophysical Phenomena (astro-ph.HE), Applied Mathematics, Astrophysics::Instrumentation and Methods for Astrophysics, Computer Science Applications1707 Computer Vision and Pattern Recognition, Gamma-ray polarization, Condensed Matter Physics, photon: energy, observatory, Nuclear astrophysics, Apace mission, Astrophysics - High Energy Astrophysical Phenomena, performance, detector: technology, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, Astrophysics::Cosmology and Extragalactic Astrophysics, gamma ray: burst, Telescope, 0103 physical sciences, supernova, Electronic, calorimeter, gamma ray: detector, Optical and Magnetic Materials, KAGRA, Electrical and Electronic Engineering, 010306 general physics, Time domain astronomy, LISA, Astronomy, Institut für Physik und Astronomie, Time-domain astronomy, sensitivity, messenger, VIRGO, 13. Climate action, Electronic, Optical and Magnetic Materials, ddc:520, galaxy, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph]
Abstract

e-ASTROGAM is a concept for a breakthrough observatory space mission carrying a gamma-ray telescope dedicated to the study of the non-thermal Universe in the photon energy range from 0.15 MeV to 3 GeV. The lower energy limit can be pushed down to energies as low as 30 keV for gamma-ray burst detection with the calorimeter. The mission is based on an advanced space-proven detector technology, with unprecedented sensitivity, angular and energy resolution, combined with remarkable polarimetric capability. Thanks to its performance in the MeV-GeV domain, substantially improving its predecessors, e-ASTROGAM will open a new window on the non-thermal Universe, making pioneering observations of the most powerful Galactic and extragalactic sources, elucidating the nature of their relativistic outflows and their effects on the surroundings. With a line sensitivity in the MeV energy range one to two orders of magnitude better than previous and current generation instruments, e-ASTROGAM will determine the origin of key isotopes fundamental for the understanding of supernova explosion and the chemical evolution of our Galaxy. The mission will be a major player of the multiwavelength, multimessenger time-domain astronomy of the 2030s, and provide unique data of significant interest to a broad astronomical community, complementary to powerful observatories such as LISA, LIGO, Virgo, KAGRA, the Einstein Telescope and the Cosmic Explorer, IceCube-Gen2 and KM3NeT, SKA, ALMA, JWST, E-ELT, LSST, Athena, and the Cherenkov Telescope Array., Comment: 15 pages, 7 figures. Submitted to the proceedings of the conference SPIE Astronomical Telescopes and Instrumentation 2018: Ultraviolet to Gamma Ray. v2: corrections of authors' affiliations

Published
2018
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134. Glial responses during epileptogenesis in Mus musculus point to potential therapeutic targets

Author

Kalozoumi, G. Kel-Margoulis, O. Vafiadaki, E. Greenberg, D. Bernard, H. Soreq, H. Depaulis, A. Sanoudou, D.

Abstract

The Mesio-Temporal Lobe Epilepsy syndrome is the most common form of intractable epilepsy. It is characterized by recurrence of focal seizures and is often associated with hippocampal sclerosis and drug resistance. We aimed to characterize the molecular changes occurring during the initial stages of epileptogenesis in search of new therapeutic targets for Mesio-Temporal Lobe Epilepsy. We used a mouse model obtained by intra-hippocampal microinjection of kainate and performed hippocampal whole genome expression analysis at 6h, 12h and 24h post-injection, followed by multilevel bioinformatics analysis. We report significant changes in immune and inflammatory responses, neuronal network reorganization processes and glial functions, predominantly initiated during status epilepticus at 12h and persistent after the end of status epilepticus at 24h post-kainate. Upstream regulator analysis highlighted Cyba, Cybb and Vim as central regulators of multiple overexpressed genes implicated in glial responses at 24h. In silico microRNA analysis indicated that miR-9, miR-19b, miR-129, and miR-223 may regulate the expression of glial-associated genes at 24h. Our data support the hypothesis that glial-mediated inflammatory response holds a key role during epileptogenesis, and that microglial cells may participate in the initial process of epileptogenesis through increased ROS production via the NOX complex. © 2018 Kalozoumi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Published
2018

136. Topographic heterogeneity explains patterns of vegetation response to climate change (1972–2008) across a mountain landscape, Niwot Ridge, Colorado

Author

Clifton P. Bueno de Mesquita, Connor D. Bernard, Katherine C. Rosemond, Noah P. Molotch, Luke S. Tillmann, and Katharine N. Suding

Subjects
0106 biological sciences, 010504 meteorology & atmospheric sciences, solar radiation, Biome, alpine vegetation, Climate change, 010603 evolutionary biology, 01 natural sciences, topography, snowpack, GE1-350, QH540-549.5, Ecology, Evolution, Behavior and Systematics, 0105 earth and related environmental sciences, Earth-Surface Processes, Global and Planetary Change, Ecology, Elevation, Vegetation, Snowpack, Snow, Tundra, Environmental sciences, climate change, Environmental science, Climate model, sense organs, Physical geography
Abstract

The distributions of biomes worldwide are predicted to shift as vegetation tracks climate change. Ecologists often use coarse-scale climate models to predict these shifts along broad elevational and latitudinal gradients, but these assessments could fail to capture important dynamics by ignoring fine-scale heterogeneity. We ask how the elevational ranges of vegetation types have changed in a mountainous landscape, and investigate the influence of fine-scale topographic, snowpack, and soil properties on vegetation change. We manually classified vegetation from high-resolution repeat aerial photographs from 1972 and 2008 at Niwot Ridge, Colorado, USA, and generally found that trees and shrubs colonized tundra, while tundra colonized barren soils. Only shrubs expanded their elevational range. Several fine-scale topographic, soil and snow characteristics, including elevation, slope, solar radiation, soil bulk density, and interannual snowpack variability, modulated where plant establishment occurred. Each vegetation type had a unique suite of variables best predicting its establishment in new areas. We suggest that fine-scale heterogeneity may strongly control how plants in mountainous regions respond to climate change, and different vegetation types may be sensitive to different aspects of this heterogeneity. An improved understanding of the factors controlling vegetation change gives us a broader understanding of ecosystem response to climate change, nitrogen deposition, and release from grazing.

Published
2018
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137. C++ implementation of Bethe–Heitler, 5D, polarized, γ→e+e− pair conversion event generator

Author

I. Semeniouk and D. Bernard

Subjects
Nuclear physics, Physics, Nuclear and High Energy Physics, Recoil, Generator (computer programming), 010308 nuclear & particles physics, 0103 physical sciences, Gamma ray, Probability density function, 010303 astronomy & astrophysics, 01 natural sciences, Instrumentation, Event generator
Abstract

We present the C++ implementation of an event generator for linearly-polarized gamma-ray conversions to γ→e+e− pairs. The generator uses the full 5D Bethe–Heitler probability density function for the generation of the γ→e+e− pair and for the recoil of the target nucleus. The same code is used for triplet generation. We present a verification of the model by comparing sample distributions with theoretical predictions.

Published
2019
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138. Compton polarimetry revisited

Author

D. Bernard

Subjects
Free electron model, Physics, Nuclear and High Energy Physics, Work (thermodynamics), Physics - Instrumentation and Detectors, media_common.quotation_subject, Gamma ray, Polarimetry, Compton scattering, FOS: Physical sciences, Estimator, Instrumentation and Detectors (physics.ins-det), Photon energy, Asymmetry, Computational physics, Classical mechanics, Astrophysics - Instrumentation and Methods for Astrophysics, Instrumentation and Methods for Astrophysics (astro-ph.IM), Instrumentation, media_common
Abstract

I compute the average polarisation asymmetry from the Klein-Nishina differential cross section on free electrons at rest. As expected from the expression for the asymmetry, the average asymmetry is found to decrease like the inverse of the incident photon energy asymptotically at high energy. I then compute a simple estimator of the polarisation fraction that makes optimal use of all the kinematic information present in an event final state, by the use of "moments" method, and I compare its statistical power to that of a simple fit of the azimuthal distribution. In contrast to polarimetry with pair creation, for which I obtained an improvement by a factor of larger than two in a previous work, here for Compton scattering the improvement is only of 10-20 %., 10 pages, 3 figures, accepted for publication in NIM A

Published
2015
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139. Depression, Language, and Affect

Author

Jared D. Bernard, Jenna L. Baddeley, Benjamin F. Rodriguez, and Philip A. Burke

Subjects
Linguistics and Language, Pronoun, Sociology and Political Science, Social Psychology, 05 social sciences, 050109 social psychology, Affect (psychology), 050105 experimental psychology, Language and Linguistics, Education, Developmental psychology, Style (sociolinguistics), Mood, Anthropology, 0501 psychology and cognitive sciences, Baseline (configuration management), Psychology, On Language, Depression (differential diagnoses)
Abstract

Literature suggests that depression influences how individuals communicate. However, no studies examine the impact of affective state on language. The current study examined the influence of depression and affective state on linguistic style. Findings suggest that depression and temporary negative moods both affect pronoun use, but depression influences use of first-person pronouns, whereas negative affect influences use of third-person pronouns.

Published
2015
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140. Evaluation of the impact of urban pollution on the quality of skin: a multicentre study in Mexico

Author

D.-M. Pham, Quang Lan Nguyen, C. Camus, M.-A. Lefebvre, B. Boussouira, and D. Bernard

Subjects
Adult, Male, Pollution, Aging, Pathology, medicine.medical_specialty, Urban Population, media_common.quotation_subject, medicine.medical_treatment, Population, Pharmaceutical Science, Physiology, Human skin, Dermatology, Excretion, Clinical study, Corneodesmosin, Young Adult, Colloid and Surface Chemistry, Air Pollution, Mexico city, Drug Discovery, Humans, Medicine, education, Mexico, Weather, Skin, media_common, education.field_of_study, integumentary system, business.industry, Vitamin E, Middle Aged, Chemistry (miscellaneous), Female, business
Abstract

SynopsisObjective After pilot and preliminary studies aimed at identifying pertinent biochemical parameters, a multicenter clinical study was performed to evaluate the effect of pollution on human skin. Methods The clinical study was performed in collaboration with the ‘Centre Regional de lutte contre le cancer de Montpellier’ and the ‘National Institute of Public Health of Mexico’ on 96 subjects in Mexico City (exposed to pollution) and 93 subjects in Cuernavaca (less exposed to pollution). Both biochemical and clinical skin parameters were studied. Results The study demonstrated significant quantitative and qualitative modifications of parameters related to sebum excretion in Mexico City compared to Cuernavaca one: An increased level of sebum excretion rate, a lower level of vitamin E and squalene in sebum, an increase of lactic acid and a higher erythematous index on the face of the subjects. In the stratum corneum, a significant higher level of carbonylated proteins and a lower level of IL 1α were noticed, as well as a decrease of ATP concentration with a decrease of chymotrysin like activity, without modifications of corneodesmosin content and trypsin like activity. From a clinical point of view, a higher frequency of atopic and urticarial skins, a higher frequency of red dermographism, an important seborrheic status at the forehead level and a lower level of dandruffs were noted in Mexico City population. The analysis taking into account the sex does not modify the observed results. Conclusion The study demonstrated an important impact of polluted environmental conditions on skin quality, evidencing important modifications of superficial biochemical parameters. The cause/effects relationships of these modifications remain, however, to be further assessed by a complementary in vitro/in vivo approaches.

Published
2015
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141. Duodenal perforation: A rare complication of ALN Optional ® vena cava filter

Author

F Bardin, M Coudert, and D Bernard

Subjects
medicine.medical_specialty, Vena cava filters, Radiological and Ultrasound Technology, Vena cava, medicine.diagnostic_test, business.industry, Computed tomography, General Medicine, 030204 cardiovascular system & hematology, 030218 nuclear medicine & medical imaging, Surgery, Duodenal Diseases, 03 medical and health sciences, 0302 clinical medicine, Medicine, Radiology, Nuclear Medicine and imaging, Radiology, business, Complication, Duodenal Perforation
Published
2016
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142. Are cirrhotic patients awaiting liver transplantation protected against vaccine-preventable diseases?

Author

Claire Goumard, S. Jauréguiberry, M. Tran Minh, Yves Chrétien, Yvon Calmus, D. Bernard, P. Lebray, A. Mazzola, and Filomena Conti

Subjects
Microbiology (medical), Liver Cirrhosis, medicine.medical_specialty, Vaccines, business.industry, medicine.medical_treatment, Vaccination, General Medicine, 030230 surgery, Liver transplantation, Communicable Diseases, Health Surveys, Liver Transplantation, 03 medical and health sciences, 0302 clinical medicine, Infectious Diseases, Communicable Disease Control, medicine, Humans, 030211 gastroenterology & hepatology, Vaccine-preventable diseases, Pre-Exposure Prophylaxis, business, Intensive care medicine
Published
2017

143. Calorimeter-less gamma-ray telescopes: Optimal measurement of charged particle momentum from multiple scattering by Bayesian analysis of Kalman filtering innovations

Author

Mikael Frosini, D. Bernard, Laboratoire Leprince-Ringuet ( LLR ), Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS ), Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS)

Subjects
0209 industrial biotechnology, Physics - Instrumentation and Detectors, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, FOS: Physical sciences, 02 engineering and technology, 7. Clean energy, [ PHYS.PHYS.PHYS-DATA-AN ] Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an], law.invention, Telescope, Momentum, 020901 industrial engineering & automation, Optics, law, 0202 electrical engineering, electronic engineering, information engineering, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Instrumentation and Methods for Astrophysics (astro-ph.IM), [ PHYS.PHYS.PHYS-INS-DET ] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physics, Calorimeter (particle physics), Spectrometer, Scattering, business.industry, Detector, Kalman filter, Instrumentation and Detectors (physics.ins-det), Transition radiation detector, Physics - Data Analysis, Statistics and Probability, 020201 artificial intelligence & image processing, Astrophysics - Instrumentation and Methods for Astrophysics, business, Data Analysis, Statistics and Probability (physics.data-an), [PHYS.PHYS.PHYS-DATA-AN]Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an]
Abstract

Novel gamma-ray telescope schemes (silicon wafer stacks, emulsions, gas detectors) are being developed so as to bridge the sensitivity gap between Compton and pair-creation telescopes. The lower average density with respect to the tungsten/silicon active target of the Fermi-LAT makes large effective-area telescopes voluminous objects, for which the photon energy measurement by conventional means (calorimeter, magnetic spectrometer, transition radiation detector) is a challenge for the mass budget of the space mission. We present an optimal measurement of track momentum by the multiple measurement of the angular deflections induced by multiple scattering in the active target itself, using a Bayesian analysis of the filtering innovations of a series of Kalman filters applied to the track. For a silicon-wafer-stack telescope, the method yields meaningful results up to a couple of GeV/c., Comment: Presented at the 7th Fermi Symposium 2017, 15-20 October 2017, Garmisch-Partenkirchen, Germany. Submitted to Proceedings of Science (PoS(IFS2017)126)

Published
2017
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144. Temporal analysis of an unprecedented data set for the $\gamma$-ray blazar 1ES 1215+303: Fermi-LAT and VERITAS light curves spanning ten years

Author

Reshmi Mukherjee, Giuliana Noto, J. Valverde, Deirdre Horan, D. Bernard, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Fermi-LAT, VERITAS, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Laboratoire Leprince-Ringuet ( LLR ), and Institut National de Physique Nucléaire et de Physique des Particules du CNRS ( IN2P3 ) -École polytechnique ( X ) -Centre National de la Recherche Scientifique ( CNRS )

Subjects
jet: blazar, 0209 industrial biotechnology, [ PHYS.ASTR ] Physics [physics]/Astrophysics [astro-ph], Astrophysics::High Energy Astrophysical Phenomena, energy spectrum, Flux, 02 engineering and technology, Astrophysics, Spectral line, GLAST, VHE, 020901 industrial engineering & automation, [ PHYS.HEXP ] Physics [physics]/High Energy Physics - Experiment [hep-ex], 0202 electrical engineering, electronic engineering, information engineering, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Blazar, Physics, energy: high, Gamma ray, Light curve, Data set, flux, Automatic Keywords, gamma ray, 020201 artificial intelligence & image processing, VERITAS, Astrophysics - High Energy Astrophysical Phenomena, [PHYS.ASTR]Physics [physics]/Astrophysics [astro-ph], Fermi Gamma-ray Space Telescope, BL Lac object
Abstract

We present here the results of the analysis of the $\gamma$-ray blazar, 1ES 1215+303, over a 10-year period, from 2008 to 2017, measured at high energies (HE; 200 MeV $< E $ 100 GeV) by Fermi-LAT and VERITAS. This is the longest temporal study of this high-frequency-peaked BL Lac object (HBL) at $\gamma$-ray energies to date. The spectrum follows a log parabola over this time period, and its HE and VHE spectra are well-connected. Its flux is sufficiently strong at HE to allow us to bin the Fermi-LAT data in 3-day intervals, enabling us to investigate the temporal evolution of the flux in unprecedented detail. Several flaring episodes were detected and evidence for an overall trend of increasing flux over the span of the 10 years was observed. These light curves, in addition to the spectra, are presented. This unique data set will help us to advance our understanding of the underlying physical processes in blazar jets., Comment: Presented at the 7th Fermi Symposium 2017, 15-20 October 2017, Garmisch-Partenkirchen, Germany. Submitted to Proceedings of Science (PoS(IFS2017)116)

Published
2017
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145. Search for Invisible Decays of a Dark Photon Produced in e+e− Collisions at BaBar

Author

D. J. Payne, M. Verderi, J. Chauveau, F. De Mori, A. M. Rossi, Joseph Izen, S. Martellotti, I. M. Nugent, A. Giuffrida, D. S. Chao, M. Davier, V. B. Golubev, Heiko Lacker, A. Roodman, Roland Waldi, Abner Soffer, J. L. Ritchie, F. Ferroni, U. Mallik, Paul Fraser Harrison, Ju-Young Kim, T. E. Latham, M. Carpinelli, Stephen Robert Wagner, M. K. Sullivan, J. Ocariz, T. S. Miyashita, K. R. Schubert, N. Neri, T. S. Mattison, E. Fioravanti, C. Hast, D. J. Lange, G. Piredda, G. Wormser, A. Palano, Florian Urs Bernlochner, F. Palombo, T. Lueck, R. Y. So, R. Sacco, R. Godang, Z. C. Huard, W. Panduro Vazquez, P. Taras, E. P. Solodov, D. B. MacFarlane, M. Rama, R. Cenci, M. Fritsch, J. W. Gary, J. A. McKenna, David Hutchcroft, E. Paoloni, A. Zallo, T. J. Gershon, T. Schroeder, S. Bettarini, Yu G. Kolomensky, W. S. Lockman, J. P. Coleman, W. R. Innes, F. Anulli, S. Luitz, A. Filippi, P. Patteri, Alessandro Gaz, D. Gamba, J. Va’vra, M. V. Purohit, M. Bellis, R. Cheaib, J. Albert, Elisa Manoni, B. Bhuyan, D. Aston, C. H. Chen, Andrei Gritsan, B. G. Fulsom, J. J. Walsh, S. M. Spanier, J. Dorfan, M. Heß, N. Tasneem, D. N. Brown, R. Faccini, F. Ferrarotto, A. J. Lankford, Mark Derdzinski, R. Cowan, L. M. Cremaldi, M. T. Graham, J. M. LoSecco, J. P. Lees, F. Le Diberder, S. Prell, A. M. Lutz, I. Garzia, A. J.S. Smith, D. G. Hitlin, James H Cochran, B. Dey, G. D. Lafferty, K. Yu Todyshev, R. C. Field, A. Oyanguren, S. H. Robertson, R. Gorodeisky, Herbert Koch, S. Passaggio, R. Stroili, F. Forti, D. A. Roberts, C. H. Cheng, H. A. Neal, P. Ongmongkolkul, K. Griessinger, Aidan Randle-Conde, I. M. Peruzzi, G. Casarosa, C. Bünger, Yu I. Skovpen, R. de Sangro, G. R. Bonneaud, V. Santoro, T. Leddig, A. Lusiani, C. Touramanis, W. J. Wisniewski, Sau Lan Wu, A. Hafner, O. Grünberg, E. M. T. Puccio, A. R. Buzykaev, M. S. Alam, A. Beaulieu, E. Grauges, Mario Giorgi, James R. Wilson, R. Calabrese, G. Eigen, Simon Akar, D. J. Summers, M. Bomben, R. J. Sobie, L. Vitale, F. Martinez-Vidal, Dominik Müller, G. A. Cowan, G. J. King, C. L. Davis, M. Ebert, J. M. Roney, Stephen Sekula, J. G. Smith, V. P. Druzhinin, C. Bozzi, E. Luppi, H. Ahmed, N. Guttman, G. De Nardo, R. F. Schwitters, F. Simonetto, G. Marchiori, A. Jawahery, A. P. Onuchin, X. C. Lou, B. T. Meadows, G. Raven, V. E. Blinov, K. Honscheid, R. J. Barlow, G. Cibinetto, M. Posocco, Crisostomo Sciacca, G. Rizzo, Colin Jessop, R. Prepost, M. D. Sokoloff, P. R. Burchat, A. Calcaterra, D. W. G. S. Leith, G. Calderini, S. Emery, E. A. Kravchenko, G. Vasseur, K. T. Flood, Alessandro Pilloni, D. R. Peimer, C. Hearty, R. Kowalewski, C. Cartaro, Maurizio Biasini, Owen Rosser Long, L. Sun, Adrian John Bevan, Douglas Wright, S. I. Serednyakov, F. Bianchi, S. Dittrich, E. Gabathuler, M. R. Convery, F. C. Porter, A. G. Denig, M. Chrzaszcz, C. Voß, D. Bettoni, B. N. Ratcliff, C. Patrignani, V. Tisserand, A. M. Eisner, Sw. Banerjee, G. Simi, N. Arnaud, Tim Adye, R. D. Kass, Martino Margoni, G. Finocchiaro, M. Rotondo, M. Röhrken, F. F. Wilson, B. Oberhof, V. Poireau, M. Piccolo, P. C. Kim, G. Batignani, E. Ben-Haim, B. Echenard, D. Bernard, W. Dunwoodie, J. A. Ernst, W. Gradl, B. G. Pushpawela, L. Lanceri, and F. Di Lodovico

Subjects
Physics, Particle physics, Muon, 010308 nuclear & particles physics, Electron–positron annihilation, Dark matter, General Physics and Astronomy, Coupling (probability), 01 natural sciences, Dark photon, B-factory, Nuclear physics, 0103 physical sciences, High Energy Physics::Experiment, Production (computer science), 010306 general physics, Boson
Abstract

We search for single-photon events in 53 fb^{-1} of e^{+}e^{-} collision data collected with the BABAR detector at the PEP-II B-Factory. We look for events with a single high-energy photon and a large missing momentum and energy, consistent with production of a spin-1 particle A^{'} through the process e^{+}e^{-}→γA^{'}; A^{'}→invisible. Such particles, referred to as "dark photons," are motivated by theories applying a U(1) gauge symmetry to dark matter. We find no evidence for such processes and set 90% confidence level upper limits on the coupling strength of A^{'} to e^{+}e^{-} in the mass range m_{A^{'}}≤8 GeV. In particular, our limits exclude the values of the A^{'} coupling suggested by the dark-photon interpretation of the muon (g-2)_{μ} anomaly, as well as a broad range of parameters for the dark-sector models.

Published
2017
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146. Butterflies regulate wing temperatures using radiative cooling

Author

Nanfang Yu, Norman Nan Shi, Julianne N. Pelaez, Crystal Ren, Gary D. Bernard, Naomi E. Pierce, and Cheng Chia Tsai

Subjects
0106 biological sciences, Wing, Materials science, Radiative cooling, business.industry, 010401 analytical chemistry, Butterfly wing, 010603 evolutionary biology, 01 natural sciences, 0104 chemical sciences, Behavioral traits, Optics, Proper function, Butterfly, business
Abstract

Butterfly wings are live organs embedded with multiple sensory neurons and, in some species, with pheromoneproducing cells. The proper function of butterfly wings demands a suitable temperature range, but the wings can overheat quickly in the sun due to their small thermal capacity. We developed an infrared technique to map butterfly wing temperatures and discovered that despite the wings’ diverse visible colors, regions of wings that contain live cells are the coolest, resulting from the thickness of the wings and scale nanostructures. We also demonstrated that butterflies use behavioral traits to prevent overheating of their wings.

Published
2017
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147. Nano-structured wild moth cocoon fibers as radiative cooling and waveguiding optical materials

Author

Catherine L. Craig, Gary D. Bernard, Nanfang Yu, Norman Nan Shi, and Cheng-Chia Tsai

Subjects
Anderson localization, Materials science, Birefringence, Scattering, Radiative transfer, Emissivity, Physics::Optics, Astrophysics::Cosmology and Extragalactic Astrophysics, Fiber, Composite material, Spinning, Waveguide (optics)
Abstract

The study shows that comet moth cocoon fibers exhibit radiative cooing properties with enhanced solar reflectivity and thermal emissivity. Nanostructured voids inside the cocoon fiber enables the cocoons to exhibit strong scattering in the visible and near-infrared. These structures also allow the fibers to exhibit strong shape birefringence and directional reflectivity. Optical waveguiding due to transverse Anderson localization is observed in these natural fibers, where the invariance and large concentration of the voids in the longitudinal direction allow the fiber to confine light in the transverse direction. To mimic the optical effects generated by these natural silk fibers, nanostructured voids are introduced into regenerated silk fibers through wet spinning to enhance reflectivity in the solar spectrum.

Published
2017
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148. Fission fragment yield distribution in the heavy-mass region from the Pu239 ( nth,f ) reaction

Author

D. Bernard, Olivier Litaize, L. Mathieu, C. Sage, Ulli Köster, Aurelien Blanc, Dwaipayan Biswas, T. Materna, Grégoire Kessedjian, A. Ebran, Y. K. Gupta, Stefano Panebianco, H. Faust, Olivier Serot, Audrey Letourneau, S. Julien-Laferrière, and A. Chebboubi

Subjects
Physics, Mass distribution, 010308 nuclear & particles physics, Fission, Nuclear data, 01 natural sciences, Distribution (mathematics), Relative yield, Monte carlo code, Yield (chemistry), 0103 physical sciences, Atomic physics, Nuclear Experiment, 010306 general physics
Abstract

The fission fragment yield distribution has been measured in the $^{239}\mathrm{Pu}\left({n}_{\mathrm{th}},f\right)$ reaction in the mass region of $A=126$ to 150 using the Lohengrin recoil-mass spectrometer. Three independent experimental campaigns were performed, allowing a significant reduction of the uncertainties compared to evaluated nuclear data libraries. The long-standing discrepancy of around 10% for the relative yield of $A=134$ reported in JEF-2.2 and JEFF-3.1.1 data libraries is finally solved. Moreover, the measured mass distribution in thermal neutron-induced fission does not show any significant dip around the shell closure ($A=136$) as seen in heavy-ion fission data of $^{208}\mathrm{Pb}$($^{18}\mathrm{O}$, $f$) and $^{238}\mathrm{U}$($^{18}\mathrm{O}$, $f$) reactions. Lastly, comparisons between our experimental data and the predictions from Monte Carlo codes (gef and fifrelin) are presented and discussed.

Published
2017
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149. A Comprehensive Analysis of Polarized $\gamma $ -ray Beam Data with the HARPO Demonstrator

Author

P. Poilleux, M. Frotin, R. Yonamine, Satoshi Hashimoto, Y. Minamiyama, D. Horan, D. Baudin, D. Calvet, I. Semeniouk, H. Ohkuma, P. Baron, S. Miyamoto, A. Delbart, P. Sizun, Masashi Yamaguchi, D. Gotz, P. Bruel, Philippe Gros, M. Louzir, D. Bernard, D. Attié, S. Wang, Paul Colas, B. Giebels, Takuya Kotaka, S. Daté, Akinori Takemoto, Y. Geerebaert, Sho Amano, Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire Leprince-Ringuet (LLR), Centre National de la Recherche Scientifique (CNRS)-École polytechnique (X)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3), Astrophysique Interprétation Modélisation (AIM (UMR_7158 / UMR_E_9005 / UM_112)), Centre National de la Recherche Scientifique (CNRS)-Institut national des sciences de l'Univers (INSU - CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris Diderot - Paris 7 (UPD7), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-École polytechnique (X)-Centre National de la Recherche Scientifique (CNRS), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut national des sciences de l'Univers (INSU - CNRS)-Université Paris Diderot - Paris 7 (UPD7)-Centre National de la Recherche Scientifique (CNRS), and Astrophysique Interprétation Modélisation (AIM (UMR7158 / UMR_E_9005 / UM_112))

Subjects
gamma ray: polarization, Physics::Instrumentation and Detectors, Astrophysics::High Energy Astrophysical Phenomena, Polarimetry, 01 natural sciences, 7. Clean energy, law.invention, Gamma-ray, Nuclear physics, Telescope, gamma ray: cosmic radiation, law, 0103 physical sciences, Angular resolution, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Nuclear Experiment, 010303 astronomy & astrophysics, Physics, 010308 nuclear & particles physics, Gamma ray, Astrophysics::Instrumentation and Methods for Astrophysics, Polarimeter, Saturation, polarization: monitoring, time projection chamber, Pair production, angular resolution, TPC, Beam (structure), performance, Fermi Gamma-ray Space Telescope
Abstract

International audience; We investigate the feasibility of gaseous TPC as a telescope and a polarimeter for cosmic gamma-rays, focussing on the energy range from 1 to 100 MeV. Our beam results show the angular resolution can reach a factor of 2 better than that of the Fermi LAT. We also demonstrate polarimetry with a high significance and an excellent dilution factor, for the first time above the pair production threshold and below 1 GeV.

Published
2017
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150. Improved Mixed Oxide Fuel Calculations with the Evaluated Nuclear Data Library JEFF-3.2

Author

Olivier Litaize, A. Santamarina, J. F. Vidal, Patrick Blaise, Luiz C Leal, Gilles Noguere, B. Roque, Pierre Leconte, D. Bernard, Y. Peneliau, O. Bouland, CEA-Direction des Energies (ex-Direction de l'Energie Nucléaire) (CEA-DES (ex-DEN)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Oak Ridge National Laboratory [Oak Ridge] (ORNL), UT-Battelle, LLC, and This work was supported by the french industrial partners (EDF and AREVA) through the SINET project of the Nuclear Energy Division of CEA.

Subjects
Americium, [PHYS.NUCL]Physics [physics]/Nuclear Theory [nucl-th], 010308 nuclear & particles physics, Fission, Monte Carlo method, Nuclear data, chemistry.chemical_element, MOX, Power reactor, Oak Ridge National Laboratory, [PHYS.NEXP]Physics [physics]/Nuclear Experiment [nucl-ex], 01 natural sciences, Plutonium, Nuclear physics, Nuclear Energy and Engineering, chemistry, 0103 physical sciences, Environmental science, 010306 general physics, MOX fuel, EOLE
Abstract

In this study, an overestimation of the keff values for mixed oxide (MOX) fuels was identified with Monte Carlo (TRIPOLI-4) and deterministic (APOLLO2) calculations based on the Joint Evaluated Fission and Fusion (JEFF) evaluated nuclear data library. The overestimation becomes sizeable with Pit aging, reaching a reactivity change of Delta(p)similar or equal to+700 pcm for integral measurements carried out with MOX fuel containing a large amount of americium. This bias was observed for various critical configurations performed in the zero power reactor EOLE of the Commissariat a l'energie atomique et aux energies alternatives (CEA), Cadarache, France. The present work focuses on the improvements achieved with the new 239PU and 241Am evaluated nuclear data files available in the latest version of the JEFF library (JEFF-3.2). The resolved resonance range of the plutonium evaluation was reevaluated at Oak Ridge National Laboratory (ORNL), Oak Ridge, Tennessee, with the Ski/NH code in collaboration with CEA Cadarache. The resonance parameters of the americium evaluation were obtained with the REFIT code in collaboration with the research institutes Institute for Reference Materials and Measurements aRmm, Geel, Belgium, and Institut de recherche sur les lois fondamentales de l'Univers ofio, Saclay, France.

Published
2017
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