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670 results on '"D'Amico, C."'

105. Association between reduced lymphocyte beta-adrenergic receptors and left ventricular dysfunction in young obese subjects

Author

Merlino, G., ROSARIO SCAGLIONE, Salvatore Corrao, D Amico, C., Paterna, Salvatore, Anna Licata, Parrinello, Gaspare, Ganguzza, A., Licata, G., Merlino G, Scaglione R, Corrao S, D'Amico C, Paterna S, Licata A, Parrinello G, Ganguzza A, and Licata G

Subjects
Adult, Male, Aging, Settore MED/09 - Medicina Interna, Radioimmunoassay, Peripheral obesity, Central Obesity, lymphocyte beta adrenergic receptors, left ventricular function, Stroke Volume, Settore MED/11 - Malattie Dell'Apparato Cardiovascolare, Ventricular Function, Left, Catecholamines, Echocardiography, Receptors, Adrenergic, beta, Humans, Insulin, Regression Analysis, Female, Lymphocytes, Obesity, Cardiac Output, Radionuclide Angiography, Chromatography, High Pressure Liquid
Abstract

This study was designed to evaluate total (t) and surface (s) beta-adrenergic receptors (BAR) density and their relationships with left ventricular function in young obese subjects. BAR density, plasma insulin, catecholamines and left ventricular function were evaluated in 27 young obese subjects (BMI30.5 kg/m2 for males and27.3 kg/m2 for females) without other risk factors for cardiovascular diseases (smoking, hypertension, diabetes and lipid abnormalities) and in 20 lean controls (BMI25 kg/m2 for males and24.7 kg/m2 for females). Both groups were matched for gender, age and body height. BAR density was evaluated according to Böyum and De Blasi methods. Plasma catecholamines by high perfusion liquid chromatography and fasting immunoreactive plasma insulin (IRI) levels by RIA were also measured. Casual (c) and 24 h ambulatory mean blood pressure (MBP/24h) were determined. Radionuclide angiocardiography was used to measure left ventricular ejection fraction (LVEF), peak filling rate (PFR), time to PFR (tPFR), cardiac output (CO) and stroke volume (SV). Total left ventricular mass (LVM), indexed for height (LVM/H), left ventricular diastolic dimension (LVDD) and interventricular septal (IVS) thickness by echocardio-graphic study were calculated. LVEF, PFR, BARt, BARs were significantly lower (P0.0001) and plasma IRI, CO, SV (P0.0001), LVM (P0.003), LVM/H (P0.004), LVDD (P0.02) and tPFR (P0.02) were significantly higher in obese subjects than in lean controls. BARt and BARs correlated inversely with BMI, SV and LVDD.(ABSTRACT TRUNCATED AT 250 WORDS)

Published
1994

112. Different expressivity of BRCA1 and BRCA2: analysis of 179 Italian pedigrees with identified mutation RID A-1110-2010

Author

Aretini, P, D'Andrea, E, Pasini, B, Viel, A, Costantini, Rm, Cortesi, L, Ricevuto, E, Agata, S, Bisegna, R, Boiocchi, M, Caligo, Ma, Chieco Bianchi, L, Cipollini, G, Crucianelli, R, D'Amico, C, Federico, M, Ghimenti, C, De Giacomi, C, De Nicolo, A, Della Puppa, L, Ferrari, S, Ficorella, C, Iandolo, D, Manoukian, S, Marchetti, P, Marroni, F, Menin, C, Montagna, M, Ottini, L, Pensotti, V, Pierotti, M, Radice, P, Santarosa, M, Silingardi, V, Turchetti, D, Bevilacqua, G, and Presciuttini, Silvano

Published
2003

113. Efficient point-by-point Bragg gratings fabricated in embedded laser-written silica waveguides using ultrafast Bessel beams

Author

Zhang, G., Cheng, G., Bhuyan, M., D’Amico, C., and Stoian, R.

Abstract

We demonstrate highly efficient Bragg gratings written point-by-point by sequential single-pulse ultrashort Bessel laser beams in laser photoinscribed single-mode waveguides in bulk fused silica. The use of chirped non-diffractive Bessel beams determines a strong Bragg resonance in a weak-to-strong transitional regime, augmenting to a record value of 40  dB/cm at 1550 nm in the third order. The Bessel-induced refractive index modulation is negative and localized to sub-micrometer (200 nm) transverse scales. The strong light confinement in Bessel beams ensuring uniform one-dimensional void conditions thus allows for enhanced precision in the Bragg grating waveguide design. We demonstrate flexible fabrication of multiplexed waveguide gratings for multiple and tunable spectral resonances.

Published
2018

119. Ostracoda and Mollusca biodiversity and hydrochemical features in Late Miocene brackish basins of Italy

Author

Ligios, S., Anadón, Pere, Castorina, F., D'Amico, C., Esu, D., Gliozzi, E., Gramigna, P., Mola, M., Monegato, G., Ligios, S., Anadón, Pere, Castorina, F., D'Amico, C., Esu, D., Gliozzi, E., Gramigna, P., Mola, M., and Monegato, G.

Abstract

Late Miocene brackish ostracods and molluscs collected in three Italian basins show noticeable differences in their taxonomic composition, despite their capability of dispersing across wide geographic areas. In the Venetian-Friulian Basin (northern Italy), the upper Tortonian sediments contain oligotypic ostracod assemblages including Hemicyprideis dacica dacica, Hemicytheria pejinovicensis, and Loxoconcha cf. L. josephi and few gastropods referable to Planorbidae and Stenothyroides, which are typical of the central Paratethys. In central Italy, the brackish ostracods and molluscs recovered from upper Tortonian-lower Messinian deposits from four Tuscan basins (Volterra-Radicondoli, Velona, Baccinello-Cinigiano, and Valdelsa) display high affinity at a generic level but strong endemicity at a specific level. At Cessaniti (southern Italy), the upper Tortonian unit contains oligotypic brackish ostracods and molluscs: Mediocytherideis (Sylvestra) posterobursa, Cyprideis ruggierii, Loxoconcha cf. L. biformata, and Zonocypris membranae quadricella characterise the ostracod fauna, while Granulolabium bicinctum and Hydrobia frauenfeldi are the dominant molluscs. The recovered ostracods have a strong affinity with brackish species from central and eastern Palaeo-Mediterranean areas, whereas the molluscs present a Paratethyan origin. Despite the fact that the basins are all brackish and partly coeval, the systematics of these assemblages highlights the absence of common species among the three studied areas. Geochemical analyses (stable isotopes and trace elements) are performed on ostracods, and 87Sr/ 86Sr ratios are established in molluscs and echinoids. The results suggest brackish environments with different compositions and origins of solutes in the three different areas. The Tuscan basins are characterised by brackish waters, with NaCl-enriched waters coming from aquifers of Triassic evaporite bedrock. The brackish deposits of the Venetian-Friulian Basin and Cessaniti a

Published
2012

134. Microsatellite instability is correlated with lymph node-positive breast cancer

Author

De Marchis L, Contegiacomo A, D'Amico C, Raffaele Palmirotta, Pizzi C, Ottini L, Mastranzo P, Figliolini M, Petrella G, Amanti C, Battista P, Ar, Bianco, Frati L, Cama A, and Mariani-Costantini R

Subjects
aged, female, adult, middle aged, breast neoplasms, genetic markers, genetics, genetics/physiopathology, humans, lymphatic metastasis, microsatellite repeats
Abstract

We analyzed 81 cases of primary breast carcinoma and 7 cases of fibroadenoma for microsatellite instability at eight loci. Twenty-seven cases (33.3%) manifested aberrant microsatellite alleles: 7 (8.6%) at one locus and 20 (24.7%) at two or more loci [tumors with replication error-positive (RER+) phenotype]. No evidence of microsatellite instability was observed in fibroadenomas. We investigated correlations between RER+ phenotype and clinicopathological characteristics of the carcinomas. The RER+ phenotype was statistically associated with large tumor diameter; of 19 RER+ tumors with measured size, 16 were2 cm, compared to 28 of 58 tumors with no evidence of microsatellite instability or with shifts in allele sizes limited to one locus (P/= 0.005, chi2 test). Consistently, there was also a strong statistical association between RER+ phenotype and lymph node metastasis; 14 of 19 RER+ tumors with known lymph node status were N+, compared to 15 of 59 tumors with no evidence of microsatellite instability or with allele shifts limited to one locus (P/= 0.0002, chi2 test). Correlations with age of patients, proliferative activity, histotype (ductal versus lobular), and grade of differentiation were not statistically significant, although the RER+ phenotype was more frequent in lobular and high-grade ductal carcinomas, in carcinomas with high proliferative activity, and in carcinomas from patients/=50 years. Data concerning cancer(s) in first and/or second degree relatives were available for 66 cases, including 33 positive and 33 negative for family history of cancer. No correlations were detected between RER+ phenotype and family history of cancer. In conclusion, our results indicate that in breast cancer, microsatellite instability is associated with clinicopathological parameters that are considered predictors of recurrent disease and aggressive behavior.

Published
1997

143. A Multicenter Phase II Randomized Trial of Docetaxel/Gemcitabine versus Docetaxel/Capecitabine as First-Line Treatment for Advanced Breast Cancer: A Gruppo Oncologico Italia Meridionale Study

Author

Vici, P., primary, Giotta, F., additional, Di Lauro, L., additional, Sergi, D., additional, Vizza, E., additional, Mariani, L., additional, Latorre, A., additional, Pizzuti, L., additional, D’Amico, C., additional, Giannarelli, D., additional, and Colucci, G., additional

Published
2011
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