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1,071 results on '"Crampin, Amelia"'

104. Association between household air pollution and nasopharyngeal pneumococcal carriage in Malawian infants (MSCAPE): a nested, prospective, observational study

Author

Dherani, Mukesh K, primary, Pope, Daniel, additional, Tafatatha, Terence, additional, Heinsbroek, Ellen, additional, Chartier, Ryan, additional, Mwalukomo, Thandie, additional, Crampin, Amelia, additional, Mitsi, Elena, additional, German, Esther L, additional, Nikolaou, Elissavet, additional, Solórzano, Carla, additional, Ferreira, Daniela M, additional, Swarthout, Todd D, additional, Hinds, Jason, additional, Mortimer, Kevin, additional, Gordon, Stephen B, additional, French, Neil, additional, and Bruce, Nigel G, additional

Published
2022
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105. ACTR1Ahas pleiotropic effects on risk of leprosy, inflammatory bowel disease and atopy

Author

Gilchrist, James J, primary, Auckland, Kathryn, additional, Parks, Tom, additional, Mentzer, Alexander J, additional, Goldblatt, Lily, additional, Naranbhai, Vivek, additional, Band, Gavin, additional, Rockett, Kirk A, additional, Toure, Ousmane B, additional, Konate, Salimata, additional, Sissoko, Sibiri, additional, Djimdé, Abdoulaye A, additional, Thera, Mahamadou A, additional, Doumbo, Ogobara K, additional, Sow, Samba, additional, Floyd, Sian, additional, Pönnighaus, Jörg M, additional, Warndorff, David K, additional, Crampin, Amelia C, additional, Fine, Paul EM, additional, Fairfax, Benjamin P, additional, and Hill, Adrian VS, additional

Published
2022
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106. BCG re-vaccination in Malawi: 30-year follow-up of a large, randomised, double-blind, placebo-controlled trial

Author

Glynn, Judith R, Fielding, Katherine, Mzembe, Themba, Sichali, Lifted, Banda, Louis, McLean, Estelle, Kanjala, Chifundo, Crampin, Amelia C, Ponnighaus, Jorg M, Warndorff, David K, Fine, Paul EM, and Karonga Prevention Trial Group

Abstract

BACKGROUND: A large, double-blind, randomised, placebo-controlled trial of repeat BCG found 49% efficacy against leprosy but no protection against tuberculosis after 6-9 years' follow-up in 1995. We report here additional follow-up, which resulted in greatly increased tuberculosis case numbers, and allowed subgroup analysis. METHODS: Nearly 47 000 individuals of all ages living in northern Malawi with a BCG vaccine scar were randomly assigned (1:1) between 1986 and 1989 to receive a second BCG or placebo. The investigators and project staff remained masked to all interventions. Enhanced passive surveillance ensured ascertainment of tuberculosis and leprosy to the end of 2018. Tuberculosis case definitions included rigorous microbiological or histological confirmation. Prespecified subgroup analyses were by tuberculosis type, age at vaccination, time since vaccination, previous tuberculin reactivity, HIV status and Mycobacterium tuberculosis lineage. The original trial is registered with ISRCTN registry, ISRCTN11311670. FINDINGS: In follow-up until Dec 31, 2018, 824 participants had developed tuberculosis, including 786 with pulmonary disease, of whom 383 (63%) of 607 with known HIV status were HIV positive. There was no effect of a second BCG overall (odds ratio [OR] 0·92; 95% CI 0·80-1·05), or for pulmonary (0·93; 0·81-1·07), or lymph node tuberculosis (0·60; 0·31-1·17). The OR was lower for those with known HIV-negative tuberculosis (0·77; 0·59-1·00), for those vaccinated as children (aged

Published
2021

107. Cotrimoxazole prophylaxis reduces mortality in human immunodeficiency virus-positive tuberculosis patients in Karonga District, Malawi

Author

Mwaungulu Frank B.D., Floyd Sian, Crampin Amelia C., Kasimba Simplex, Malema Simon, Kanyongoloka Huxley, Harries Anthony D., Glynn Judith R., and Fine Paul E.M.

Subjects
Trimethoprim-sulfamethoxazole combination/pharmacology, Tuberculosis/mortality, Tuberculosis/drug therapy, AIDS-related opportunistic infections/drug therapy, HIV infections, Treatment outcome, Survival analysis, Cohort studies, Malawi, Public aspects of medicine, RA1-1270
Abstract

OBJECTIVE: To estimate the impact of cotrimoxazole prophylaxis on the survival of human immunodeficiency virus (HIV)-positive tuberculosis (TB) patients. METHODS: A cohort study with a historical comparison group was conducted. End-of-treatment outcomes and 18-month survival were compared between TB patients registered in 1999 and patients registered in 2000 in Karonga District, Malawi. Case ascertainment, treatment and outpatient follow-up were identical in the two years except that in 2000 cotrimoxazole prophylaxis was offered to HIV-positive patients in addition to routine care. The prophylaxis was provided from the time a patient was identified as HIV-positive until 12 months after registration. Analyses were carried out on an intention-to-treat basis for all TB patients, and also separately by HIV status, TB type and certainty of diagnosis. FINDINGS: 355 and 362 TB patients were registered in 1999 and 2000, respectively; 70% were HIV-positive. The overall case fatality rate fell from 37% to 29%, i.e. for every 12.5 TB patients treated, one death was averted. Case fatality rates were unchanged between the two years in HIV-negative patients, but fell in HIV-positive patients from 43% to 24%. The improved survival became apparent after the first 2 months and was maintained beyond the end of treatment. The improvement was most marked in patients with smear-positive TB and others with confirmed TB diagnoses. CONCLUSION: Survival of HIV-positive TB patients improved dramatically with the addition of cotrimoxazole prophylaxis to the treatment regimen. The improvement can be attributed to cotrimoxazole because other factors were unchanged and the survival of HIV-negative patients was not improved. Cotrimoxazole prophylaxis should therefore be added to the routine care of HIV-positive TB patients.

Published
2004

110. Author Correction: Genome-wide analysis of multi- and extensively drug-resistant Mycobacterium tuberculosis

Author

Coll, Francesc, Phelan, Jody, Hill-Cawthorne, Grant A., Nair, Mridul B., Mallard, Kim, Ali, Shahjahan, Abdallah, Abdallah M., Alghamdi, Saad, Alsomali, Mona, Ahmed, Abdallah O., Portelli, Stephanie, Oppong, Yaa, Alves, Adriana, Bessa, Theolis Barbosa, Campino, Susana, Caws, Maxine, Chatterjee, Anirvan, Crampin, Amelia C., Dheda, Keertan, Furnham, Nicholas, Glynn, Judith R., Grandjean, Louis, Ha, Dang Minh, Hasan, Rumina, Hasan, Zahra, Hibberd, Martin L., Joloba, Moses, Jones-López, Edward C., Matsumoto, Tomoshige, Miranda, Anabela, Moore, David J., Mocillo, Nora, Panaiotov, Stefan, Parkhill, Julian, Penha, Carlos, Perdigão, João, Portugal, Isabel, Rchiad, Zineb, Robledo, Jaime, Sheen, Patricia, Shesha, Nashwa Talaat, Sirgel, Frik A., Sola, Christophe, Sousa, Erivelton Oliveira, Streicher, Elizabeth M., Van Helden, Paul, Viveiros, Miguel, Warren, Robert M., McNerney, Ruth, Pain, Arnab, and Clark, Taane G.

Published
2018
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115. Age patterns of HIV incidence in eastern and southern Africa: a collaborative analysis of observational general population cohort studies

Author

Risher, Kathryn, Cori, Anne, Reniers, Georges, Marston, Milly, Calvert, Clara, Crampin, Amelia, Dadirai, Tawanda, Dube, Albert, Gregson, Simon, Herbst, Kobus, Lutalo, Tom, Moorhouse, Louisa, Mtenga, Baltazar, Nabukalu, Doreen, Newton, Robert, Price, Alison J, Tlhajoane, Malebogo, Todd, Jim, Tomlin, Keith, Urassa, Mark, Vandormael, Alain, Fraser, Christophe, Slaymaker, Emma, Eaton, Jeffrey W, and ALPHA Network

Abstract

BACKGROUND: As the HIV epidemic in sub-Saharan Africa matures, evidence about the age distribution of new HIV infections and how this has changed over the epidemic is needed to guide HIV prevention. We assessed trends in age-specific HIV incidence in six population-based cohort studies in eastern and southern Africa, reporting changes in average age at infection, age distribution of new infections, and birth cohort cumulative incidence. METHODS: We used a Bayesian model to reconstruct age-specific HIV incidence from repeated observations of individuals’ HIV serostatus and survival collected among population HIV cohorts in rural Malawi, South Africa, Tanzania, Uganda, and Zimbabwe. The HIV incidence rate by age, time and sex was modelled using smooth splines functions. Incidence trends were estimated separately by sex and study. Estimated incidence and prevalence results for 2000-2017, standardised to study population distribution, were used to estimate average age at infection and proportion of new infections by age. FINDINGS: Age-specific incidence declined at all ages, though the timing and pattern of decline varied by study. The average age at infection was higher in men (cohort means: 27·8-34·6 years) than women (cohort means: 24·8-29·6 years). Between 2000 and 2017, the average age at infection increased slightly: cohort means 0·5-2·8 years among men and -0·2-2·5 years among women. Across studies, between 38-63% (cohort means) of women’s infections were among 15-24-year-olds and between 30-63% of men’s infections were in 20-29-year-olds. Lifetime risk of HIV declined for successive birth cohorts. INTERPRETATION: HIV incidence declined in all age groups and shifted slightly, but not dramatically, to older ages. Disproportionate new HIV infections occur among 15-24-year-old women and 20-29-year-old men, supporting focused prevention in these groups. But 40-60% of infections were outside these ages, emphasising the importance of providing appropriate HIV prevention to adults of all ages. FUNDING: Bill and Melinda Gates Foundation.

Published
2021

116. secondary data analysis of a cluster randomized controlled trial: improved cookstoves associated with reduction in incidence of low birthweight in rural Malawi.

Author

Best, Rebecca, Malava, Jullita, Dube, Albert, Katundu, Cynthia, Kalobekamo, Fredrick, Mortimer, Kevin, Gordon, Stephen B, Nyirenda, Moffat, Crampin, Amelia, and McLean, Estelle

Subjects
CLUSTER randomized controlled trials, SECONDARY analysis, BIRTH weight, CLUSTER analysis (Statistics), SEQUENTIAL analysis
Abstract

Background In northern rural Malawi, the majority of households cook using open fires and there is also a high burden of adverse birth outcomes. The use of open fires or highly polluting cookstoves is associated with low birthweight in babies. There is mixed evidence on whether implementation of cleaner burning cookstoves reduces the number of babies born with low birthweight. Methods This is a secondary analysis of a cluster randomized control trial in Malawi, conducted over 2014–17. Households were randomized to receive improved cookstoves or to continue current practices. For this analysis, the primary outcome was low birthweight in households under routine demographic surveillance, among births occurring within the trial time frame (N  = 4010). A subset of data with stricter exposure definitions respecting the original randomized allocation was also analysed (N  = 1050). A causal, forwards modelling approach was used. Results The main dataset showed evidence of effect of the intervention on low birthweight [adjusted odds ratio (aOR) 0.69; 95% CI 0.48–0.99, n  = 2788). The subset analysis lacked power to provide evidence of association between improved cookstoves and low birthweight in the stricter exposure definition (aOR 0.62; 95% CI 0.35–1.09, n  = 932). Conclusions This study provides some evidence that an improved cookstove intervention in rural Malawi reduced the number of babies born with low birthweight by 30%. This direction of the effect was also seen in the subset analysis. The analysis suggests that the intervention reduced the number of infants born prematurely or with intra-uterine growth restriction, indicating that improved cookstoves could be a useful maternal health intervention. [ABSTRACT FROM AUTHOR]

Published
2022
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120. P09 Estimation of the causal effect of church attendance on risk ofMycobacterium tuberculosisinfection in young children in rural Malawi using targeted maximum likelihood estimation

Author

Khan, Palwasha, primary, Baisley, Kathy, additional, Martinez, Leo, additional, Mzembe, Themba, additional, Chiumya, Regina, additional, Kranzer, Katharina, additional, Fine, Paul, additional, Fielding, Katherine, additional, Crampin, Amelia, additional, and Glynn, Judith, additional

Published
2021
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121. Heterogeneous contributions of change in population distribution of body mass index to change in obesity and underweight NCD Risk Factor Collaboration (NCD-RisC)

Author

Iurilli, Maria L. C., Zhou, Bin, Bennett, James E., Carrillo-Larco, Rodrigo M., Sophiea, Marisa K., Rodriguez-Martinez, Andrea, Bixby, Honor, Solomon, Bethlehem D., Taddei, Cristina, Danaei, Goodarz, Di Cesare, Mariachiara, Stevens, Gretchen A., Riley, Leanne M., Savin, Stefan, Cowan, Melanie J., Bovet, Pascal, Damasceno, Albertino, Chirita-Emandi, Adela, Hayes, Alison J., Ikeda, Nayu, Jackson, Rod T., Khang, Young-Ho, Laxmaiah, Avula, Liu, Jing, Miranda, J. Jaime, Saidi, Olfa, Sebert, Sylvain, Soric, Maroje, Starc, Gregor, Gregg, Edward W., Abarca-Gomez, Leandra, Abdeen, Ziad A., Abdrakhmanova, Shynar, Ghaffar, Suhaila Abdul, Rahim, Hanan F. Abdul, Abu-Rmeileh, Niveen M., Garba, Jamila Abubakar, Acosta-Cazares, Benjamin, Adams, Robert J., Aekplakorn, Wichai, Afsana, Kaosar, Afzal, Shoaib, Agdeppa, Imelda A., Aghazadeh-Attari, Javad, Aguilar-Salinas, Carlos A., Agyemang, Charles, Ahmad, Mohamad Hasnan, Ahmad, Noor Ani, Ahmadi, Ali, Ahmadi, Naser, Ahmed, Soheir H., Ahrens, Wolfgang, Aitmurzaeva, Gulmira, Ajlouni, Kamel, Al-Hazzaa, Hazzaa M., Al-Lahou, Badreya, Al-Raddadi, Rajaa, Alarouj, Monira, AlBuhairan, Fadia, AlDhukair, Shahla, Ali, Mohamed M., Alkandari, Abdullah, Alkerwi, Ala'a, Allin, Kristine, Alvarez-Pedrerol, Mar, Aly, Eman, Amarapurkar, Deepak N., Amiri, Parisa, Amougou, Norbert, Amouyel, Philippe, Andersen, Lars Bo, Anderssen, Sigmund A., Angquist, Lars, Anjana, Ranjit Mohan, Ansari-Moghaddam, Alireza, Aounallah-Skhiri, Hajer, Araujo, Joana, Ariansen, Inger, Aris, Tahir, Arku, Raphael E., Arlappa, Nimmathota, Aryal, Krishna K., Aspelund, Thor, Assah, Felix K., Assuncao, Maria Cecilia F., Aung, May Soe, Auvinen, Juha, Avdicova, Maria, Avi, Shina, Azevedo, Ana, Azimi-Nezhad, Mohsen, Azizi, Fereidoun, Azmin, Mehrdad, Babu, Bontha, Jorgensen, Maja Boksgaard, Baharudin, Azli, Bahijri, Suhad, Baker, Jennifer L., Balakrishna, Nagalla, Bamoshmoosh, Mohamed, Banach, Maciej, Bandosz, Piotr, Banegas, Jose R., Baran, Joanna, Barbagallo, Carlo M., Barcelo, Alberto, Barkat, Amina, Barros, Aluisio Jd, Gomes Barros, Mauro Virgilio, Basit, Abdul, Bastos, Joao Luiz D., Bata, Iqbal, Batieha, Anwar M., Batista, Rosangela L., Battakova, Zhamilya, Batyrbek, Assembekov, Baur, Louise A., Beaglehole, Robert, Bel-Serrat, Silvia, Belavendra, Antonisamy, Ben Romdhane, Habiba, Benedics, Judith, Benet, Mikhail, Bergh, Ingunn Holden, Berkinbayev, Salim, Bernabe-Ortiz, Antonio, Bernotiene, Gailute, Bettiol, Heloisa, Bezerra, Jorge, Bhagyalaxmi, Aroor, Bharadwaj, Sumit, Bhargava, Santosh K., Bhutta, Zulfiqar A., Bi, Hongsheng, Bi, Yufang, Bia, Daniel, Lele, Elysee Claude Bika, Bikbov, Mukharram M., Bista, Bihungum, Bjelica, Dusko J., Bjerregaard, Peter, Bjertness, Espen, Bjertness, Marius B., Bjorkelund, Cecilia, Bloch, Katia, Blokstra, Anneke, Bo, Simona, Bobak, Martin, Boddy, Lynne M., Boehm, Bernhard O., Boeing, Heiner, Boggia, Jose G., Bogova, Elena, Boissonnet, Carlos P., Bojesen, Stig E., Bonaccio, Marialaura, Bongard, Vanina, Bonilla-Vargas, Alice, Bopp, Matthias, Borghs, Herman, Braeckevelt, Lien, Braeckman, Lutgart, Bragt, Marjolijn C. E., Brajkovich, Imperia, Branca, Francesco, Breckenkamp, Juergen, Breda, Joao, Brenner, Hermann, Brewster, Lizzy M., Brian, Garry R., Brinduse, Lacramioara, Brophy, Sinead, Bruno, Graziella, Bueno-de-Mesquita, H. Bas, Bugge, Anna, Buoncristiano, Marta, Burazeri, Genc, Burns, Con, Cabrera de Leon, Antonio, Cacciottolo, Joseph, Cai, Hui, Cama, Tilema, Cameron, Christine, Camolas, Jose, Can, Gunay, Candido, Ana Paula C., Canete, Felicia, Capanzana, Mario, Capkova, Nadezda, Capuano, Eduardo, Capuano, Vincenzo, Cardol, Marloes, Cardoso, Viviane C., Carlsson, Axel C., Carmuega, Esteban, Carvalho, Joana, Casajus, Jose A., Casanueva, Felipe F., Celikcan, Ertugrul, Censi, Laura, Cervantes-Loaiza, Marvin, Cesar, Juraci A., Chamukuttan, Snehalatha, Chan, Angelique W., Chan, Queenie, Chaturvedi, Himanshu K., Chaturvedi, Nish, Rahim, Norsyamlina Che Abdul, Chee, Miao Li, Chen, Chien-Jen, Chen, Fangfang, Chen, Huashuai, Chen, Shuohua, Chen, Zhengming, Cheng, Ching-Yu, Cheraghian, Bahman, Chetrit, Angela, Chikova-Iscener, Ekaterina, Chiolero, Arnaud, Chiou, Shu-Ti, Chirlaque, Maria-Dolores, Cho, Belong, Christensen, Kaare, Christofaro, Diego G. [UNESP], Chudek, Jerzy, Cifkova, Renata, Cilia, Michelle, Cinteza, Eliza, Claessens, Frank, Clarke, Janine, Clays, Els, Cohen, Emmanuel, Concin, Hans, Confortin, Susana C., Cooper, Cyrus, Coppinger, Tara C., Corpeleijn, Eva, Costanzo, Simona, Cottel, Dominique, Cowell, Chris, Craig, Cora L., Crampin, Amelia C., Crujeiras, Ana B., Csilla, Semanova, Cucu, Alexandra M., Cui, Liufu, Cureau, Felipe, Czenczek-Lewandowska, Ewelina, D'Arrigo, Graziella, D'Orsi, Eleonora, Dacica, Liliana, Dal Re Saavedra, Maria Angeles, Dallongeville, Jean, Damsgaard, Camilla T., Dankner, Rachel, Dantoft, Thomas M., Dasgupta, Parasmani, Dastgiri, Saeed, Dauchet, Luc, Davletov, Kairat, De Backer, Guy, De Bacquer, Dirk, Gaetano, Giovanni de, De Henauw, Stefaan, Oliveira, Paula Duarte de, De Ridder, David, De Ridder, Karin, Rooij, Susanne R. de, De Smedt, Delphine, Deepa, Mohan, Deev, Alexander D., DeGennaro, Vincent, Dehghan, Abbas, Delisle, Helene, Delpeuch, Francis, Demarest, Stefaan, Dennison, Elaine, Deren, Katarzyna, Deschamps, Valerie, Dhimal, Meghnath, Di Castelnuovo, Augusto F., Dias-da-Costa, Juvenal Soares, Diaz-Sanchez, Maria Elena, Diaz, Alejandro, Dika, Zivka, Djalalinia, Shirin, Djordjic, Visnja, Do, Ha T. P., Dobson, Annette J., Donati, Maria Benedetta, Donfrancesco, Chiara, Donoso, Silvana P., Doring, Angela, Dorobantu, Maria, Dorosty, Ahmad Reza, Doua, Kouamelan, Dragano, Nico, Drygas, Wojciech, Duan, Jia Li, Duante, Charmaine A., Duboz, Priscilla, Duda, Rosemary B., Duleva, Vesselka, Dulskiene, Virginija, Dumith, Samuel C., Dushpanova, Anar, Dzerve, Vilnis, Dziankowska-Zaborszczyk, Elzbieta, Eddie, Ricky, Eftekhar, Ebrahim, Egbagbe, Eruke E., Eggertsen, Robert, Eghtesad, Sareh, Eiben, Gabriele, Ekelund, Ulf, El-Khateeb, Mohammad, El Ati, Jalila, Eldemire-Shearer, Denise, Eliasen, Marie, Elliott, Paul, Engle-Stone, Reina, Enguerran, Macia, Erasmus, Rajiv T., Erbel, Raimund, Erem, Cihangir, Eriksen, Louise, Eriksson, Johan G., Escobedo-de la Pena, Jorge, Eslami, Saeid, Esmaeili, Ali, Evans, Alun, Faeh, David, Fakhretdinova, Albina A., Fall, Caroline H., Faramarzi, Elnaz, Farjam, Mojtaba, Sant'Angelo, Victoria Farrugia, Farzadfar, Farshad, Fattahi, Mohammad Reza, Fawwad, Asher, Felix-Redondo, Francisco J., Ferguson, Trevor S., Fernandes, Romulo A. [UNESP], Fernandez-Berges, Daniel, Ferrante, Daniel, Ferrao, Thomas, Ferrari, Marika, Ferrario, Marco M., Ferreccio, Catterina, Ferrer, Eldridge, Ferrieres, Jean, Figueiro, Thamara Hubler, Fijalkowska, Anna, Fink, Gunther, Fischer, Krista, Foo, Leng Huat, Forsner, Maria, Fouad, Heba M., Francis, Damian K., Franco, Maria do Carmo, Frikke-Schmidt, Ruth, Frontera, Guillermo, Fuchs, Flavio D., Fuchs, Sandra C., Fujiati, Isti I., Fujita, Yuki, Fumihiko, Matsuda, Furusawa, Takuro, Gaciong, Zbigniew, Gafencu, Mihai, Galbarczyk, Andrzej, Galenkamp, Henrike, Galeone, Daniela, Galfo, Myriam, Galvano, Fabio, Gao, Jingli, Garcia-de-la-Hera, Manoli, Garcia-Solano, Marta, Gareta, Dickman, Garnett, Sarah P., Gaspoz, Jean-Michel, Gasull, Magda, Araujo Gaya, Adroaldo Cesar, Gaya, Anelise Reis, Gazzinelli, Andrea, Gehring, Ulrike, Geiger, Harald, Geleijnse, Johanna M., Ghanbari, Ali, Ghasemi, Erfan, Gheorghe-Fronea, Oana-Florentina, Giampaoli, Simona, Gianfagna, Francesco, Gill, Tiffany K., Giovannelli, Jonathan, Gironella, Glen, Giwercman, Aleksander, Gkiouras, Konstantinos, Godos, Justyna, Gogen, Sibel, Goldberg, Marcel, Goldsmith, Rebecca A., Goltzman, David, Gomez, Santiago F., Gomula, Aleksandra, Cordeiro da Silva, Bruna Goncalves, Goncalves, Helen, Gonzalez-Chica, David A., Gonzalez-Gross, Marcela, Gonzalez-Leon, Margot, Gonzalez-Rivas, Juan P., Gonzalez-Villalpando, Clicerio, Gonzalez-Villalpando, Maria-Elena, Gonzalez, Angel R., Gottrand, Frederic, Graca, Antonio Pedro, Graff-Iversen, Sidsel, Grafnetter, Dusan, Grajda, Aneta, Grammatikopoulou, Maria G., Gregor, Ronald D., Grodzicki, Tomasz, Groholt, Else Karin, Grontved, Anders, Grosso, Giuseppe, Gruden, Gabriella, Gu, Dongfeng, Gualdi-Russo, Emanuela, Guallar-Castillon, Pilar, Gualtieri, Andrea, Gudmundsson, Elias F., Gudnason, Vilmundur, Guerrero, Ramiro, Guessous, Idris, Guimaraes, Andre L., Gulliford, Martin C., Gunnlaugsdottir, Johanna, Gunter, Marc J., Guo, Xiu-Hua, Guo, Yin, Gupta, Prakash C., Gupta, Rajeev, Gureje, Oye, Gurzkowska, Beata, Gutierrez-Gonzalez, Enrique, Gutierrez, Laura, Gutzwiller, Felix, Ha, Seongjun, Hadaegh, Farzad, Hadjigeorgiou, Charalambos A., Haghshenas, Rosa, Hakimi, Hamid, Halkjaer, Jytte, Hambleton, Ian R., Hamzeh, Behrooz, Hange, Dominique, Hanif, Abu A. M., Hantunen, Sari, Hao, Jie, Kumar, Rachakulla Hari, Hashemi-Shahri, Seyed Mohammad, Hassapidou, Maria, Hata, Jun, Haugsgjerd, Teresa, He, Jiang, He, Yuan, He, Yuna, Heidinger-Felso, Regina, Heinen, Mirjam, Hejgaard, Tatjana, Hendriks, Marleen Elisabeth, Henrique, Rafael dos Santos, Henriques, Ana, Hernandez Cadena, Leticia, Herrala, Sauli, Herrera, Victor M., Herter-Aeberli, Isabelle, Heshmat, Ramin, Hill, Allan G., Ho, Sai Yin, Ho, Suzanne C., Hobbs, Michael, Holdsworth, Michelle, Homayounfar, Reza, Homs, Clara, Hopman, Wilma M., Horimoto, Andrea R. V. R., Hormiga, Claudia M., Horta, Bernardo L., Houti, Leila, Howitt, Christina, Thein Thein Htay, Htet, Aung Soe, Htike, Maung Maung Than, Hu, Yonghua, Huerta, Jose Maria, Huhtaniemi, Ilpo Tapani, Huiart, Laetitia, Petrescu, Constanta Huidumac, Huisman, Martijn, Husseini, Abdullatif, Huu, Chinh Nguyen, Huybrechts, Inge, Hwalla, Nahla, Hyska, Jolanda, Iacoviello, Licia, Ibarluzea, Jesus M., Ibrahim, Mohsen M., Wong, Norazizah Ibrahim, Ikram, M. Arfan, Iotova, Violeta, Irazola, Vilma E., Ishida, Takafumi, Islam, Muhammad, Islam, Sheikh Mohammed Shariful, Iwasaki, Masanori, Jacobs, Jeremy M., Jaddou, Hashem Y., Jafar, Tazeen, James, Kenneth, Jamil, Kazi M., Jamrozik, Konrad, Janszky, Imre, Janus, Edward, Jarani, Juel, Jarvelin, Marjo-Riitta, Jasienska, Grazyna, Jelakovic, Ana, Jelakovic, Bojan, Jennings, Garry, Jha, Anjani Kumar, Jiang, Chao Qiang, Jimenez, Ramon O., Jockel, Karl-Heinz, Joffres, Michel, Johansson, Mattias, Jokelainen, Jari J., Jonas, Jost B., Jonnagaddala, Jitendra, Jorgensen, Torben, Joshi, Pradeep, Joukar, Farahnaz, Jovic, Dragana P., Jozwiak, Jacek J., Juolevi, Anne, Jurak, Gregor, Simina, Iulia Jurca, Juresa, Vesna, Kaaks, Rudolf, Kaducu, Felix O., Kafatos, Anthony, Kajantie, Eero O., Kalmatayeva, Zhanna, Kalter-Leibovici, Ofra, Kameli, Yves, Kampmann, Freja B., Kanala, Kodanda R., Kannan, Srinivasan, Kapantais, Efthymios, Karakosta, Argyro, Karhus, Line L., Karki, Khem B., Katibeh, Marzieh, Katz, Joanne, Katzmarzyk, Peter T., Kauhanen, Jussi, Kaur, Prabhdeep, Kavousi, Maryam, Kazakbaeva, Gyulli M., Keil, Ulrich, Boker, Lital Keinan, Keinanen-Kiukaanniemi, Sirkka, Kelishadi, Roya, Kelleher, Cecily, Kemper, Han C. G., Kengne, Andre P., Keramati, Maryam, Kerimkulova, Alina, Kersting, Mathilde, Key, Timothy, Khader, Yousef Saleh, Khalili, Davood, Khaw, Kay-Tee, Kheiri, Bahareh, Kheradmand, Motahareh, Khosravi, Alireza, Khouw, Ilse M. S. L., Kiechl-Kohlendorfer, Ursula, Kiechl, Stefan, Killewo, Japhet, Kim, Dong Wook, Kim, Hyeon Chang, Kim, Jeongseon, Kindblom, Jenny M., Klakk, Heidi, Klimek, Magdalena, Klimont, Jeannette, Klumbiene, Jurate, Knoflach, Michael, Koirala, Bhawesh, Kolle, Elin, Kolsteren, Patrick, Konig, Jurgen, Korpelainen, Raija, Korrovits, Paul, Korzycka, Magdalena, Kos, Jelena, Koskinen, Seppo, Kouda, Katsuyasu, Kovacs, Viktoria A., Kowlessur, Sudhir, Koziel, Slawomir, Kratenova, Jana, Kratzer, Wolfgang, Kriemler, Susi, Kristensen, Peter Lund, Krokstad, Steiner, Kromhout, Daan, Kruger, Herculina S., Kubinova, Ruzena, Kuciene, Renata, Kujala, Urho M., Kujundzic, Enisa, Kulaga, Zbigniew, Kumar, R. 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& Med Educ, Univ Novi Sad, Natl Inst Nutr, Univ Queensland, Ist Super Sanita, Univ Cuenca, Helmholtz Zentrum Munchen, Univ Tehran Med Sci, Minist Sante & Hyg Publ, Univ Hosp Dusseldorf, Natl Inst Cardiol, Beijing Ctr Dis Prevent & Control, UMI 3189 ESS, Beth Israel Deaconess Med Ctr, Scuola Super Sant Anna, Univ Latvia, Minist Hlth & Med Serv, Hormozgan Univ Med Sci, Univ Benin, Univ Skovde, Natl Inst Nutr & Food Technol, Univ West Indies, Univ Calif Davis, Univ Stellenbosch, Univ Duisburg Essen, Karadeniz Tech Univ, Univ Helsinki, Mashhad Univ Med Sci, Rafsanjan Univ Med Sci, Queens Univ Belfast, Tabriz Univ Med Sci, Fasa Univ Med Sci, Shiraz Univ Med Sci, Baqai Med Univ, Ctr Salud Villanueva Norte, Hosp Don Benito Villanueva Serena, Univ Insubria, Pontificia Univ Catolica Chile, Inst Mother & Child Hlth, Swiss Trop & Publ Hlth Inst, Univ Tartu, Univ Sains Malaysia, Umea Univ, Universidade Federal de São Paulo (UNIFESP), Hosp Univ Son Espases, Hosp Clin Porto Alegre, Univ Sumatera Utara, Kindai Univ, Kyoto Univ, Med Univ Warsaw, Jagiellonian Univ, Minist Salute DG Prevenz Sanit, Univ Catania, Africa Hlth Res Inst, Univ Geneva, Universidade Federal de Minas Gerais (UFMG), Univ Utrecht, Wageningen Univ, Univ Adelaide, Lund Univ, Aristotle Univ Thessaloniki, Inst Natl Sante & Rech Med, McGill Univ, Gasol Fdn, PASs Hirszfeld Inst Immunol & Expt Therapy, Univ Politecn Madrid, St Annes Univ Hosp, Ctr Estudios Diabet AC, Univ Autonoma Santo Domingo, Inst Clin & Expt Med, Childrens Mem Hlth Inst, Natl Ctr Cardiovasc Dis, Univ Ferrara, Author Sanitaria San Marino, Iceland Heart Assoc, Univ Icesi, Univ Estadual Montes Claros, Kings Coll London, Int Agcy Res Canc, Healis Sekhsaria Inst Publ Hlth, Eternal Heart Care Ctr & Res Inst, Univ Ibadan, Inst Clin Effectiveness & Hlth Policy, Natl Hlth Insurance Serv, Prevent Metab Disorders Res Ctr, Res & Educ Inst Child Hlth, Danish Canc Soc Res Ctr, Kermanshah Univ Med Sci, Univ Eastern Finland, Beijing Inst Ophthalmol, Int Hellen Univ, Kyushu Univ, Univ Bergen, Tulane Univ, Natl Res Inst Hlth & Family Planning, Chinese Ctr Dis Control & Prevent, Univ Pecs, Danish Hlth Author, Joep Lange Inst, Universidade Federal de Pernambuco (UFPE), Oulu Univ Hosp, Univ Autonoma Bucaramanga, Swiss Fed Inst Technol, Chron Dis Res Ctr, Univ Hong Kong, Chinese Univ Hong Kong, Univ Western Australia, Kingston Hlth Sci Ctr, Fdn Oftalmol Santander, Univ Oran 1, Nay Pyi Taw, Minist Hlth & Sports, Peking Univ, Vrije Univ Amsterdam Med Ctr, Amer Univ Beirut, Cairo Univ, Erasmus MC, Med Univ Varna, Univ Tokyo, Deakin Univ, Tokyo Metropolitan Inst Gerontol, Hadassah Univ Med Ctr, Norwegian Univ Sci & Technol, Univ Melbourne, Sports Univ Tirana, Univ Hosp Ctr Zagreb, Heart Fdn, Guangzhou 12th Hosp, Univ Eugenio Maria Hostos, Simon Fraser Univ, Inst Mol & Clin Ophthalmol Basel, Univ New South Wales, World Hlth Org Country Off, Guilan Univ Med Sci, Univ Opole, Finnish Inst Hlth & Welf, Gulu Univ, Univ Crete, Sri Venkateswara Univ, Sree Chitra Tirunal Inst Med Sci & Technol, Hellen Med Assoc Obes, Natl & Kapodistrian Univ Athens, Aarhus Univ, Johns Hopkins Bloomberg Sch Publ Hlth, Pennington Biomed Res Ctr, Natl Inst Epidemiol, Univ Munster, Israel Ctr Dis Control, Res Inst Primordial Prevent Noncommunicable Dis, Amsterdam UMC Publ Hlth Res Inst, South African Med Res Council, Kyrgyz State Med Acad, Res Inst Child Nutr, Shahid Beheshti Univ Med Sci, Univ Cambridge, Mazandaran Univ Med Sci, Hypertens Res Ctr, Med Univ Innsbruck, Muhimbili Univ Hlth & Allied Sci, Yonsei Univ, Natl Canc Ctr, Univ Coll South Denmark, Stat Austria, BP Koirala Inst Hlth Sci, Univ Vienna, Tartu Univ Clin, Kansai Med Univ, Hungarian Sch Sport Federat, Minist Hlth & Qual Life, Univ Hosp Ulm, North West Univ, Univ Jyvaskyla, Amrita Inst Med Sci, Inst Endocrinol, All India Inst Med Sci, African Populat & Hlth Res Ctr, Hanoi Univ Publ Hlth, Hassan First Univ Settat, Harokopio Univ, Sahlgrens Acad, Endocrinol & Metab Res Ctr, Univ Publ Hlth, Int Food Policy Res Inst, Natl Univ Singapore, Hong Kong Polytech Univ, Tampere Univ Hosp, Univ Douala, Univ Cape Town, Natl Inst Hlth Dev, West Virginia Univ, Oswaldo Cruz Fdn Rene Rachou Res Inst, Natl Taiwan Univ, Univ Chinese Acad Sci, Uppsala Univ, Taipei Med Univ, Sports Med Ctr Minho, Univ San Martin Porres, Consejeria Sanidad Junta Castilla & Leon, Univ Fed Ciencias Saude Porto Alegre, Norrbotten Cty Council, Ilembula Lutheran Hosp, Univ Fed Ouro Preto, Univ Coimbra, Coimbra Univ Hosp Ctr, Inst Neurosci Natl Res Council, Baker Heart & Diabet Inst, Agr Univ Athens, Hosp Israelita Albert Einstein, SB RAS Fed Res Ctr Inst Cytol & Genet, Univ Otago, Univ Padua, Hellen Mediterranean Univ, Loughborough Univ, Lausanne Univ Hosp, Escola Nacl Saude Publ Sergio Arouca, CIBERCV, Mary Immaculate Coll, Emory Univ, Hungarian Soc Sports Med, Paracelsus Med Univ, Univ Estadual Centro Oeste, Sherikashmir Inst Med Sci, UiT Arctic Univ Norway, ICMR Natl Ctr Dis Informat & Res, Cape Peninsula Univ Technol, Brown Univ, London Sch Hyg & Trop Med, Univ Edinburgh, Shahid Sadoughi Univ Med Sci, Robert Koch Inst, Univ Lisbon, Womens Social & Hlth Studies Fdn, Democritus Univ, Grigore T Popa Univ Med & Pharm, Univ Firenze, Ain Shams Univ, Isfahan Cardiovasc Res Ctr, Univ Strasbourg, Mulago Hosp, Univ San Carlos, Univ Limpopo, Univ Med Sci Cienfuegos, Royal Coll Surgeons Ireland, Trobe Univ, Int Inst Mol & Cell Biol, Inst Conmemorat Gorgas Estudios Salud, Dept Publ Hlth, Univ Brescia, Minist Hlth & Social Protect, Univ Limerick, Croatian Inst Publ Hlth, Univ Kebangsaan Malaysia, Bushehr Univ Med Sci, Ulm Univ, Dept Stat, Kobe Univ, Suraj Eye Inst, UNICEF, Univ Med Greifswald, Natl Inst Hyg & Epidemiol, Univ Med & Pharm Ho Chi Minh City, Hanoi Med Univ, LifeDoc Hlth, Heartfile, Eastern Mediterranean Publ Hlth Network, Univ Manchester, State Univ Med & Pharm, Tachikawa Gen Hosp, Korea Ctr Dis Control & Prevent, Japan Wildlife Res Ctr, Istanbul Univ, Univ Fed Parana, Univ Madeira, Univ Puerto Rico, Ctr Clin Res & Prevent, MRC Lifecourse Epidemiol Unit, Kwame Nkrumah Univ Sci & Technol, UniSante, Inst Canc Res, Univ Wisconsin, Heidelberg Univ, IRCCS Ente Osped Specializzato Gastroenterol S de, Zayed Univ, Catholic Univ Daegu, Univ Med Pharm Sci & Technol Targu Mures, Jivandeep Hosp, Natl Dent Care Ctr Singapore, Univ Malaga, Univ Hosp Varese, Vietnam Natl Heart Inst, Clin Med Avanzada Dr Abel Gonzalez, Leibniz Inst Prevent Res & Epidemiol BIPS, Univ Sarajevo, Cardiovasc Prevent Ctr Udine, Pisa Univ Hosp, Publ Hlth Agcy Catalonia, Inst Hosp del Mar Invest Med, Ardabil Univ Med Sci, Ctr Dis Prevent & Control, Alborz Univ Med Sci, Pure Earth, Inst Epidemiol Dis Control & Res, Univ Turku, Inst Univ Invest Atenc Primaria Jordi Gol, Univ Putra Malaysia, Univ Malaya, Sotiria Hosp, Univ Valencia, Univ Philippines, Slovak Acad Sci, Nutr Res Fdn, Minas Gerais State Secretariat Hlth, CS S Agustin Ibsalut, Amsterdam Inst Global Hlth & Dev, Natl Inst Hlth Doutor Ricardo Jorge, Univ Nove Julho, Publ Hlth Agcy Canada, Canarian Hlth Serv, Univ Ind Santander, Assoc Calabrese Epatol, Univ Minho, Fiji Natl Univ, Spanish Nutr Fdn, Publ Hlth Agcy Sweden, Inst Food Sci Natl Res Council, Sitaram Bhartia Inst Sci & Res, Kindergarten Avlonari, Natl Inst Hlth, Catalan Dept Hlth, Biodonostia Hlth Res Inst, Inst Saude Ambiental, South Karelia Social & Hlth Care Dist, McMaster Univ, Hosp Italiano Buenos Aires, Rigshosp, Acad Med Ctr Univ Amsterdam, Ctr Oral Hlth Serv & Res Midnorway, Lagos State Univ, Univ Las Palmas Gran Canaria, Comenius Univ, Natl Ctr Dis Control & Publ Hlth, Nippon Med Sch, Sungkyunkwan Univ, Finnish Inst Occupat Hlth, Publ Hlth Promot & Dev Org, St Vincents Hosp, Nes Municipal, Hlth Polytech Jakarta II Inst, Diponegoro Univ, Univ Bari, Inst Reg Sante Publ, Univ Bordeaux, Oslo Metropolitan Univ, Univ Leuven, Lamprecht & Stamm Sozialforsch & Beratung AG, Univ Bonn, Kalina Malina Kindergarten, Jikei Univ, Fu Jen Catholic Univ, Natl Stat Off, Natl Inst Publ Hlth Natl Inst Hyg, Sci Res Inst Maternal & Child Hlth, Univ Lincoln, Cent Univ Kerala, Amsterdam Publ Hlth Res Inst, Hlth Serv Murcia, Inst Invest Sanitaria Illes Balears, Univ Bologna, Hellen Hlth Fdn, Govt Med Coll, Sefako Makgatho Hlth Sci Univ, Addis Ababa Univ, Univ Ctr Occidental Lisandro Alvarado, Meharry Med Coll, Dokuz Eylul Univ, Univ Tampere, Sabiha Gokcen Ilkokulu, Polytech Inst Porto, Icahn Sch Med Mt Sinai, Univ CEU San Pablo, Univ Miguel Hernandez, Vrije Univ Amsterdam, Sunflower Nursery Sch, North Karelia Ctr Publ Hlth, Univ Witwatersrand, Med Univ Vienna, Cork Inst Technol, Inst Med Res, Xinjiang Med Univ, Shanghai Educ Dev Co Ltd, Rebro Univ, St Georges Univ London, Univ Indonesia, Minist Agr & Rural Affairs, Fudan Univ, Univ Cyprus, Niigata Univ, Int Med Univ, Iran Univ Med Sci, Ctr Diabet & Endocrine Care, Peking Univ First Hosp, Jiangsu Prov Ctr Dis Control & Prevent, Sun Yat Sen Univ, West Kazakhstan Med Univ, Inner Mongolia Med Univ, and Przedszkole 81

Subjects
Life Sciences & Biomedicine - Other Topics, Science & Technology, AUSTRALIAN ADULTS, CHINESE ADULTS, nutritional and metabolic diseases, MALNUTRITION, TRENDS, DOUBLE BURDEN, PREVALENCE, POOLED ANALYSIS, US ADULTS, SYSTEMATIC ANALYSIS, HEALTH, sense organs, skin and connective tissue diseases, Life Sciences & Biomedicine, Biology
Abstract

Made available in DSpace on 2021-06-25T15:08:19Z (GMT). No. of bitstreams: 0 Previous issue date: 2021-03-09 Wellcome Trust From 1985 to 2016, the prevalence of underweight decreased, and that of obesity and severe obesity increased, in most regions, with significant variation in the magnitude of these changes across regions. We investigated how much change in mean body mass index (BMI) explains changes in the prevalence of underweight, obesity, and severe obesity in different regions using data from 2896 population-based studies with 187 million participants. Changes in the prevalence of underweight and total obesity, and to a lesser extent severe obesity, are largely driven by shifts in the distribution of BMI, with smaller contributions from changes in the shape of the distribution. In East and Southeast Asia and sub-Saharan Africa, the underweight tail of the BMI distribution was left behind as the distribution shifted. There is a need for policies that address all forms of malnutrition by making healthy foods accessible and affordable, while restricting unhealthy foods through fiscal and regulatory restrictions. 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State Of Palest, Israel Usmanu Danfodiyo Univ Teaching Hosp, Sokoto, Nigeria Inst Mexicano Seguro Social, Mexico City, DF, Mexico Flinders Univ S Australia, Adelaide, SA, Australia Mahidol Univ, Salaya, Nakhon Pathom, Thailand BRAC James P Grant Sch Publ Hlth, Dhaka, Bangladesh Univ Copenhagen, Copenhagen, Denmark Copenhagen Univ Hosp, Copenhagen, Denmark Food & Nutr Res Inst, Taguig, Philippines Urmia Univ Med Sci, Orumiyeh, Iran Inst Nacl Ciencias Med & Nut, Mexico City, DF, Mexico Univ Amsterdam, Amsterdam, Netherlands Shahrekord Univ Med Sci, Shahrekord, Iran Noncommunicable Dis Res Ctr, Tehran, Iran Univ Oslo, Oslo, Norway Univ Bremen, Bremen, Germany Republican Ctr Hlth Promot, Bishkek, Kyrgyzstan Natl Ctr Diabet Endocrinol & Genet, Amman, Jordan Princess Nourah Bint Abdulrahman Univ, Riyadh, Saudi Arabia Kuwait Inst Sci Res, Kuwait, Kuwait King Abdulaziz Univ, Jeddah, Saudi Arabia Dasman Diabet Inst, Kuwait, Kuwait Luxembourg Inst Hlth, Strassen, Luxembourg Aldara Hosp & Med Ctr, Riyadh, Saudi Arabia King Abdullah Int Med Res Ctr, Riyadh, Saudi Arabia Bispebjerg & Frederiksberg Hosp, Copenhagen, Denmark Barcelona Inst Global Hlth CIBERESP, Barcelona, Spain World Hlth Org Reg Off Eastern Mediterranean, Cairo, Egypt Bombay Hosp & Med Res Ctr, Mumbai, Maharashtra, India Res Ctr Social Determinants Hlth, Tehran, Iran UMR CNRS MNHN 7206 Ecoanthropologie, Paris, France Univ Lille, Lille, France Lille Univ Hosp, Lille, France Western Norway Univ Appl Sci, Sogndal, Norway Norwegian Sch Sport Sci, Oslo, Norway Madras Diabet Res Fdn, Chennai, Tamil Nadu, India Zahedan Univ Med Sci, Zahedan, Iran Natl Inst Publ Hlth, Tunis, Tunisia Univ Porto, Inst Publ Hlth, Porto, Portugal Norwegian Inst Publ Hlth, Oslo, Norway Univ Massachusetts, Amherst, MA 01003 USA Abt Associates Inc, Kathmandu, Nepal Univ Iceland, Reykjavik, Iceland Univ Yaounde I, Yaounde, Cameroon Univ Fed Pelotas, Pelotas, RS, Brazil Univ Med 1, Yangon, Myanmar Banska Bystrica Reg Author Publ Hlth, Banska Bystrica, Slovakia Tel Aviv Univ, Tel Aviv, Israel Hebrew Univ Jerusalem, Jerusalem, Israel Univ Porto, Med Sch, Porto, Portugal Neyshabur Univ Med Sci, Neyshabur, Iran Res Inst Endocrine Sci, Tehran, Iran Indian Council Med Res, New Delhi, India Natl Inst Publ Hlth, Copenhagen, Denmark Univ Sci & Technol, Sanaa, Yemen Med Univ Lodz, Lodz, Poland Med Univ Gdansk, Gdansk, Poland Univ Autonoma Madrid CIBERESP, Madrid, Spain Univ Rzeszow, Rzeszow, Poland Univ Palermo, Palermo, Italy Pan Amer Hlth Org, Washington, DC USA Mohammed V Univ Rabat, Rabat, Morocco Univ Pernambuco, Recife, PE, Brazil Baqai Inst Diabetol & Endocrinol, Karachi, Pakistan Univ Fed Santa Catarina, Florianopolis, SC, Brazil Dalhousie Univ, Halifax, NS, Canada Jordan Univ Sci & Technol, Irbid, Jordan Univ Fed Maranhao, Sao Luis, Brazil Farabi Kazakh Natl Univ, Alma Ata, Kazakhstan Univ Coll Dublin, Dublin, Ireland Christian Med Coll & Hosp, Vellore, Tamil Nadu, India Fed Minist Social Affairs Hlth Care & Consumer Pr, Vienna, Austria Cafam Univ Fdn, Bogota, Colombia Kazakh Natl Med Univ, Alma Ata, Kazakhstan Lithuanian Univ Hlth Sci, Kaunas, Lithuania Univ Sao Paulo, Sao Paulo, Brazil BJ Med Coll, Ahmadabad, Gujarat, India Chirayu Med Coll, New Delhi, India Sunder Lal Jain Hosp, Delhi, India Hosp Sick Children, Toronto, ON, Canada Shandong Univ Tradit Chinese Med, Jinan, Peoples R China Shanghai Jiao Tong Univ, Sch Med, Shanghai, Peoples R China Univ Republica, Montevideo, Uruguay Inst Med Res & Med Plant Studies, Yaounde, Cameroon Ufa Eye Res Inst, Ufa, Russia Nepal Hlth Res Council, Kathmandu, Nepal Univ Montenegro, Niksic, Montenegro Univ Southern Denmark, Copenhagen, Denmark Univ Gothenburg, Gothenburg, Sweden Univ Fed Rio de Janeiro, Rio De Janeiro, Brazil Natl Inst Publ Hlth & Environm, Bilthoven, Netherlands Univ Turin, Turin, Italy UCL, London, England Liverpool John Moores Univ, Liverpool, Merseyside, England Nanyang Technol Univ Singapore, Singapore, Singapore German Inst Human Nutr, Potsdam, Germany Endocrinol Res Ctr, Moscow, Russia Ctr Educ Med & Invest Clin, Buenos Aires, DF, Argentina IRCCS Neuromed, Pozzilli, Italy Toulouse Univ, Sch Med, Toulouse, France Univ Zurich, Zurich, Switzerland Univ Hosp KU Leuven, Leuven, Belgium Flemish Agcy Care & Hlth, Brussels, Belgium Univ Ghent, Ghent, Belgium FrieslandCampina, Amersfoort, Netherlands Univ Cent Venezuela, Caracas, Venezuela Bielefeld Univ, Bielefeld, Germany World Hlth Org Reg Off Europe, Moscow, Russia German Canc Res Ctr, Heidelberg, Germany Fred Hollows Fdn, Auckland, New Zealand Univ Med & Pharm Bucharest, Bucharest, Romania Swansea Univ, Swansea, W Glam, Wales Univ Coll Copenhagen, Copenhagen, Denmark Inst Publ Hlth, Tirana, Albania Munster Technol Univ, Cork, Ireland Univ La Laguna, Tenerife, Spain Univ Malta, Msida, Malta Vanderbilt Univ, 221 Kirkland Hall, Nashville, TN 37235 USA Minist Hlth, Tongatapu, Tonga Canadian Fitness & Lifestyle Res Inst, Ottawa, ON, Canada Hosp Santa Maria, Lisbon, Portugal Istanbul Univ Cerrahpasa, Istanbul, Turkey Univ Fed Juiz de Fora, Juiz De Fora, Brazil Minist Publ Hlth, Asuncion, Paraguay Natl Inst Publ Hlth, Prague, Czech Republic Gaetano Fucito Hosp, Mercato San Severino, Italy Univ Groningen, Groningen, Netherlands Karolinska Inst, Huddinge, Sweden Ctr Estudios Nutr Infantil, Buenos Aires, DF, Argentina Univ Porto, Porto, Portugal Univ Zaragoza, Zaragoza, Spain Santiago de Compostela Univ, Santiago De Compostela, Spain Minist Hlth, Ankara, Turkey Council Agr Res & Econ, Rome, Italy Fed Univ Rio Grande, Rio Grande, Brazil India Diabet Res Fdn, Chennai, Tamil Nadu, India Duke NUS Med Sch, Singapore, Singapore ICMR Natl Inst Med Stat, New Delhi, India Singapore Eye Res Inst, Singapore, Singapore Acad Sinica, Taipei, Taiwan Capital Inst Pediat, Beijing, Peoples R China Duke Univ, Durham, NH USA Kailuan Gen Hosp, Tangshan, Peoples R China Univ Oxford, Oxford, England Ahvaz Jundishapur Univ Med Sci, Ahvaz, Iran Gertner Inst Epidemiol & Hlth Policy Res, Ramat Gan, Israel Natl Ctr Publ Hlth & Anal, Sofia, Bulgaria Univ Fribourg, Fribourg, Switzerland Minist Hlth & Welf, Taipei, Taiwan CIBER Epidemiol & Salud Publ, Murcia, Spain Univ Southern Denmark, Odense, Denmark Univ Estadual Paulista, Presidente Prudente, Brazil Med Univ Silesia, Katowice, Poland Charles Univ Prague, Prague, Czech Republic Primary Hlth Care, Floriana, Malta Carol Davila Univ Med & Pharm, Bucharest, Romania Katholieke Univ Leuven, Leuven, Belgium STAT Canada, Ottawa, ON, Canada UMR CNRS MNHN 7206 Ecoanthropol, Marseille, France Agcy Prevent & Social Med, Bregenz, Austria Univ Southampton, Southampton, Hants, England Inst Pasteur, Lille, France Malawi Epidemiol & Intervent Res Unit, Lilongwe, Malawi CIBEROBN, Madrid, Spain Univ Debrecen, Debrecen, Hungary Univ Med & Pharm Carol Davila, Bucharest, Romania Univ Fed Rio Grande do Sul, Porto Alegre, RS, Brazil CNR, Reggio Di Calabria, Italy Eftimie Murgu Univ Resita, Resita, Romania Spanish Agcy Food Safety & Nutr, Madrid, Spain Indian Stat Inst, Kolkata, India Tabriz Hlth Serv Management Res Ctr, Tabriz, Iran Geneva Univ Hosp, Geneva, Switzerland Sciensano, Brussels, Belgium Univ Med Ctr Groningen, Groningen, Netherlands Natl Res Ctr Prevent Med, Moscow, Russia Innovating Hlth Int, Port Au Prince, Haiti Univ Montreal, Montreal, PQ, Canada French Natl Res Inst Sustainable Dev, Montpellier, France French Publ Hlth Agcy, St Maurice, France Mediterranea Cardioctr, Naples, Italy Univ Vale Rio dos Sinos, Sao Leopoldo, Brazil Natl Inst Hyg Epidemiol & Microbiol, Havana, Cuba Natl Council Sci & Tech Res, Buenos Aires, DF, Argentina Minist Hlth & Med Educ, Tehran, Iran Univ Novi Sad, Novi Sad, Serbia Natl Inst Nutr, Hanoi, Vietnam Univ Queensland, Brisbane, Qld, Australia Ist Super Sanita, Rome, Italy Univ Cuenca, Cuenca, Ecuador Helmholtz Zentrum Munchen, Munich, Germany Univ Tehran Med Sci, Tehran, Iran Minist Sante & Hyg Publ, Abidjan, Cote Ivoire Univ Hosp Dusseldorf, Dusseldorf, Germany Natl Inst Cardiol, Warsaw, Poland Beijing Ctr Dis Prevent & Control, Beijing, Peoples R China UMI 3189 ESS, Marseille, France Beth Israel Deaconess Med Ctr, Boston, MA 02215 USA Scuola Super Sant Anna, Pisa, Italy Univ Latvia, Riga, Latvia Minist Hlth & Med Serv, Gizo, Solomon Islands Hormozgan Univ Med Sci, Bandar Abbas, Iran Univ Benin, Benin, Nigeria Univ Skovde, Skovde, Sweden Natl Inst Nutr & Food Technol, Tunis, Tunisia Univ West Indies, Kingston, Jamaica Univ Calif Davis, Davis, CA 95616 USA Univ Stellenbosch, Cape Town, South Africa Univ Duisburg Essen, Duisburg, Germany Karadeniz Tech Univ, Trabzon, Turkey Univ Helsinki, Helsinki, Finland Mashhad Univ Med Sci, Mashhad, Razavi Khorasan, Iran Rafsanjan Univ Med Sci, Rafsanjan, Iran Queens Univ Belfast, Belfast, Antrim, North Ireland Tabriz Univ Med Sci, Tabriz, Iran Fasa Univ Med Sci, Fasa, Iran Shiraz Univ Med Sci, Shiraz, Iran Baqai Med Univ, Karachi, Pakistan Ctr Salud Villanueva Norte, Badajoz, Spain Hosp Don Benito Villanueva Serena, Badajoz, Spain Minist Hlth, Buenos Aires, DF, Argentina Univ Insubria, Varese, Italy Pontificia Univ Catolica Chile, Santiago, Chile Inst Mother & Child Hlth, Warsaw, Poland Swiss Trop & Publ Hlth Inst, Basel, Switzerland Univ Tartu, Tartu, Estonia Univ Sains Malaysia, Kota Baharu, Kelantan, Malaysia Umea Univ, Umea, Sweden Univ Fed Sao Paulo, Sao Paulo, Brazil Hosp Univ Son Espases, Palma De Mallorca, Spain Hosp Clin Porto Alegre, Porto Alegre, RS, Brazil Univ Sumatera Utara, Medan, Indonesia Kindai Univ, Osaka, Japan Kyoto Univ, Kyoto, Japan Med Univ Warsaw, Warsaw, Poland Jagiellonian Univ, Med Coll, Krakow, Poland Minist Salute DG Prevenz Sanit, Rome, Italy Univ Catania, Catania, Italy CIBER Epidemiol & Salud Publ, Alicante, Spain Africa Hlth Res Inst, Mtubatuba, South Africa Univ Geneva, Med Sch, Geneva, Switzerland CIBER Epidemiol & Salud Publ, Barcelona, Spain Univ Fed Minas Gerais, Belo Horizonte, MG, Brazil Univ Utrecht, Utrecht, Netherlands Wageningen Univ, Wageningen, Netherlands Univ Adelaide, Adelaide, SA, Australia Lund Univ, Lund, Sweden Aristotle Univ Thessaloniki, Thessaloniki, Greece Inst Natl Sante & Rech Med, Villejuif, France Minist Hlth, Jerusalem, Israel McGill Univ, Montreal, PQ, Canada Gasol Fdn, Barcelona, Spain PASs Hirszfeld Inst Immunol & Expt Therapy, Wroclaw, Poland Univ Politecn Madrid, Madrid, Spain St Annes Univ Hosp, Brno, Czech Republic Natl Inst Publ Hlth, Cuernavaca, Morelos, Mexico Ctr Estudios Diabet AC, Mexico City, DF, Mexico Univ Autonoma Santo Domingo, Santo Domingo, Dominican Rep Minist Hlth, Lisbon, Portugal Inst Clin & Expt Med, Prague, Czech Republic Childrens Mem Hlth Inst, Warsaw, Poland Natl Ctr Cardiovasc Dis, Beijing, Peoples R China Univ Ferrara, Ferrara, Italy Author Sanitaria San Marino, San Marino, CA USA Iceland Heart Assoc, Kopavogur, Iceland Univ Icesi, Cali, Colombia Univ Estadual Montes Claros, Montes Claros, MG, Brazil Kings Coll London, London, England Int Agcy Res Canc, Lyon, France Capital Med Univ, Beijing, Peoples R China Capital Med Univ, Beijing Tongren Hosp, Beijing, Peoples R China Healis Sekhsaria Inst Publ Hlth, Navi Mumbai, India Eternal Heart Care Ctr & Res Inst, Jaipur, Rajasthan, India Univ Ibadan, Ibadan, Nigeria Inst Clin Effectiveness & Hlth Policy, Buenos Aires, DF, Argentina Natl Hlth Insurance Serv, Wonju, South Korea Prevent Metab Disorders Res Ctr, Tehran, Iran Res & Educ Inst Child Hlth, Nicosia, Cyprus Danish Canc Soc Res Ctr, Copenhagen, Denmark Univ West Indies, Cave Hill, Barbados Kermanshah Univ Med Sci, Kermanshah, Iran Univ Eastern Finland, Kuopio, Finland Beijing Inst Ophthalmol, Beijing, Peoples R China Int Hellen Univ, Thessaloniki, Greece Kyushu Univ, Fukuoka, Japan Univ Bergen, Bergen, Norway Tulane Univ, New Orleans, LA USA Natl Res Inst Hlth & Family Planning, Beijing, Peoples R China Chinese Ctr Dis Control & Prevent, Beijing, Peoples R China Univ Pecs, Pecs, Hungary Danish Hlth Author, Copenhagen, Denmark Joep Lange Inst, Amsterdam, Netherlands Univ Fed Pernambuco, Recife, PE, Brazil Oulu Univ Hosp, Oulu, Finland Univ Autonoma Bucaramanga, Bucaramanga, Colombia Swiss Fed Inst Technol, Zurich, Switzerland Chron Dis Res Ctr, Tehran, Iran Univ Hong Kong, Hong Kong, Peoples R China Chinese Univ Hong Kong, Hong Kong, Peoples R China Univ Western Australia, Perth, WA, Australia Kingston Hlth Sci Ctr, Kingston, ON, Canada Fdn Oftalmol Santander, Bucaramanga, Colombia Univ Oran 1, Oran, Algeria Nay Pyi Taw, Independent Publ Hlth Specialist, Nay Pyi Taw, Myanmar Minist Hlth & Sports, Nay Pyi Taw, Myanmar Peking Univ, Beijing, Peoples R China Natl Inst Publ Hlth, Bucharest, Romania Vrije Univ Amsterdam Med Ctr, Amsterdam, Netherlands Amer Univ Beirut, Beirut, Lebanon CIBER Epidemiol & Salud Publ, San Sebastian, Spain Cairo Univ, Cairo, Egypt Erasmus MC, Rotterdam, Netherlands Med Univ Varna, Varna, Bulgaria Univ Tokyo, Tokyo, Japan Deakin Univ, Geelong, Vic, Australia Tokyo Metropolitan Inst Gerontol, Tokyo, Japan Hadassah Univ Med Ctr, Jerusalem, Israel Norwegian Univ Sci & Technol, Trondheim, Norway Univ Melbourne, Melbourne, Vic, Australia Sports Univ Tirana, Tirana, Albania Univ Hosp Ctr Zagreb, Zagreb, Croatia Univ Zagreb, Sch Med, Zagreb, Croatia Heart Fdn, Melbourne, Vic, Australia Guangzhou 12th Hosp, Guangzhou, Peoples R China Univ Eugenio Maria Hostos, Santo Domingo, Dominican Rep Simon Fraser Univ, Burnaby, BC, Canada Inst Mol & Clin Ophthalmol Basel, Basel, Switzerland Univ New South Wales, Sydney, NSW, Australia World Hlth Org Country Off, Delhi, India Guilan Univ Med Sci, Rasht, Iran Inst Publ Hlth, Belgrade, Serbia Univ Opole, Opole, Poland Finnish Inst Hlth & Welf, Helsinki, Finland Gulu Univ, Gulu, Uganda Univ Crete, Iraklion, Greece Sri Venkateswara Univ, Tirupati, Andhra Pradesh, India Sree Chitra Tirunal Inst Med Sci & Technol, Trivandrum, Kerala, India Hellen Med Assoc Obes, Athens, Greece Natl & Kapodistrian Univ Athens, Athens, Greece Maharajgunj Med Campus, Kathmandu, Nepal Aarhus 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Estonia Kansai Med Univ, Hirakata, Osaka, Japan Hungarian Sch Sport Federat, Budapest, Hungary Minist Hlth & Qual Life, Port Louis, Mauritius Univ Hosp Ulm, Ulm, Germany North West Univ, Potchefstroom, South Africa Univ Jyvaskyla, Jyvaskyla, Finland Inst Publ Hlth, Podgorica, Montenegro Amrita Inst Med Sci, Cochin, Kerala, India Inst Endocrinol, Prague, Czech Republic All India Inst Med Sci, New Delhi, India African Populat & Hlth Res Ctr, Nairobi, Kenya Hanoi Univ Publ Hlth, Hanoi, Vietnam Hassan First Univ Settat, Settat, Morocco Minist Hlth, Algiers, Algeria Harokopio Univ, Athens, Greece Sahlgrens Acad, Gothenburg, Sweden Endocrinol & Metab Res Ctr, Tehran, Iran Univ Publ Hlth, Yangon, Myanmar Int Food Policy Res Inst, Dakar, Senegal Natl Univ Singapore, Singapore, Singapore Hong Kong Polytech Univ, Hong Kong, Peoples R China Tampere Univ Hosp, Tampere, Finland Univ Douala, Douala, Cameroon Univ Cape Town, Cape Town, South Africa Natl Inst Hlth Dev, Tallinn, Estonia West Virginia Univ, Morgantown, WV 26506 USA Oswaldo Cruz Fdn Rene Rachou Res Inst, Belo Horizonte, MG, Brazil Natl Taiwan Univ, Taipei, Taiwan Univ Chinese Acad Sci, Shanghai, Peoples R China Uppsala Univ, Uppsala, Sweden Taipei Med Univ, Taipei, Taiwan Sports Med Ctr Minho, Braga, Portugal Univ San Martin Porres, Lima, Peru Consejeria Sanidad Junta Castilla & Leon, Valladolid, Spain Univ Fed Ciencias Saude Porto Alegre, Porto Alegre, RS, Brazil Norrbotten Cty Council, Lulea, Sweden Ilembula Lutheran Hosp, Ilembula, Iran Univ Fed Ouro Preto, Ouro Preto, Brazil Univ Coimbra, Coimbra, Portugal Coimbra Univ Hosp Ctr, Coimbra, Portugal Inst Neurosci Natl Res Council, Padua, Italy Baker Heart & Diabet Inst, Melbourne, Vic, Australia Agr Univ Athens, Athens, Greece Hosp Israelita Albert Einstein, Sao Paulo, Brazil SB RAS Fed Res Ctr Inst Cytol & Genet, Novosibirsk, Russia Univ Otago, Dunedin, New Zealand Univ Padua, Padua, Italy Hellen Mediterranean Univ, Siteia, Greece Loughborough Univ, Loughborough, Leics, England Minist Hlth, Nicosia, Cyprus Lausanne Univ Hosp, Lausanne, Switzerland Escola Nacl Saude Publ Sergio Arouca, Rio De Janeiro, Brazil CIBERCV, Madrid, Spain Mary Immaculate Coll, Limerick, Ireland Emory Univ, Atlanta, GA 30322 USA Hungarian Soc Sports Med, Budapest, Hungary Paracelsus Med Univ, Salzburg, Austria Univ Estadual Centro Oeste, Guarapuava, Brazil Sherikashmir Inst Med Sci, Srinagar, India UiT Arctic Univ Norway, Tromso, Norway ICMR Natl Ctr Dis Informat & Res, Bengaluru, India Cape Peninsula Univ Technol, Cape Town, South Africa Brown Univ, Providence, RI 02912 USA London Sch Hyg & Trop Med, London, England Univ Edinburgh, Edinburgh, Midlothian, Scotland Shahid Sadoughi Univ Med Sci, Tehran, Iran Inst Natl Sante & Rech Med, Lille, France Robert Koch Inst, Berlin, Germany Univ Lisbon, Lisbon, Portugal Womens Social & Hlth Studies Fdn, Trivandrum, Kerala, India Democritus Univ, Alexandroupolis, Greece Grigore T Popa Univ Med & Pharm, Iasi, Romania Univ Firenze, Florence, Italy Ain Shams Univ, Cairo, Egypt Isfahan Cardiovasc Res Ctr, Esfahan, Iran Univ Strasbourg, Strasbourg, France Mulago Hosp, Kampala, Uganda Univ San Carlos, Guatemala City, Guatemala Univ Limpopo, Sovenga, South Africa Univ Med Sci Cienfuegos, Cienfuegos, Cuba Royal Coll Surgeons Ireland, Dublin, Ireland Trobe Univ, Melbourne, Vic, Australia Int Inst Mol & Cell Biol, Warsaw, Poland Inst Conmemorat Gorgas Estudios Salud, Panama City, Panama World Hlth Org Country Off, Lilongwe, Malawi Dept Publ Hlth, Nay Pyi Taw, Myanmar Univ Brescia, Brescia, Italy Minist Hlth & Social Protect, Dushanbe, Tajikistan Univ Limerick, Limerick, Ireland Croatian Inst Publ Hlth, Zagreb, Croatia Univ Kebangsaan Malaysia, Kuala Lumpur, Malaysia Bushehr Univ Med Sci, Bushehr, Iran Ulm Univ, Ulm, Germany Dept Stat, Kuala Lumpur, Malaysia Kobe Univ, Kobe, Hyogo, Japan Suraj Eye Inst, Nagpur, Maharashtra, India UNICEF, Yaounde, Cameroon Univ Med Greifswald, Greifswald, Germany Karolinska Inst, Stockholm, Sweden Natl Inst Hyg & Epidemiol, Hanoi, Vietnam Univ Med & Pharm Ho Chi Minh City, Ho Chi Minh City, Vietnam Hanoi Med Univ, Hanoi, Vietnam LifeDoc Hlth, Memphis, TN USA Heartfile, Islamabad, Pakistan Eastern Mediterranean Publ Hlth Network, Amman, Jordan Univ Manchester, Manchester, Lancs, England State Univ Med & Pharm, Kishinev, Moldova Tachikawa Gen Hosp, Nagaoka, Niigata, Japan Korea Ctr Dis Control & Prevent, Cheongju, South Korea Japan Wildlife Res Ctr, Tokyo, Japan Istanbul Univ, Istanbul, Turkey Minist Hlth, Bandar Seri Begawan, Brunei Univ Fed Parana, Curitiba, Parana, Brazil Univ Madeira, Funchal, Portugal Univ Puerto Rico, San Juan, PR 00936 USA Ctr Clin Res & Prevent, Glostrup, Denmark MRC Lifecourse Epidemiol Unit, Southampton, Hants, England Kwame Nkrumah Univ Sci & Technol, Kumasi, Ghana UniSante, Lausanne, Switzerland Inst Canc Res, Prevent & Clin Network, Florence, Italy Univ Wisconsin, Madison, WI USA Heidelberg Univ, Heidelberg, Germany IRCCS Ente Osped Specializzato Gastroenterol S de, Bari, Italy Zayed Univ, Abu Dhabi, U Arab Emirates Catholic Univ Daegu, Daegu, South Korea Univ Med Pharm Sci & Technol Targu Mures, Targu Mures, Romania Jivandeep Hosp, Anand, Gujarat, India South African Med Res Council, Durban, South Africa Natl Dent Care Ctr Singapore, Singapore, Singapore Univ Malaga, Malaga, Spain Univ Hosp Varese, Varese, Italy Vietnam Natl Heart Inst, Hanoi, Vietnam Clin Med Avanzada Dr Abel Gonzalez, Santo Domingo, Dominican Rep Leibniz Inst Prevent Res & Epidemiol BIPS, Bremen, Germany Univ Sarajevo, Sarajevo, Bosnia & Herceg Cardiovasc Prevent Ctr Udine, Udine, Italy Pisa Univ Hosp, Pisa, Italy Minist Hlth & Med Serv, Honiara, Solomon Islands Publ Hlth Agcy Catalonia, Barcelona, Spain Inst Hosp del Mar Invest Med, Barcelona, Spain Ardabil Univ Med Sci, Ardebil, Iran Ctr Dis Prevent & Control, Riga, Latvia Alborz Univ Med Sci, Karaj, Iran Minist Hlth, Hanoi, Vietnam Pure Earth, Dhaka, Bangladesh Inst Epidemiol Dis Control & Res, Dhaka, Bangladesh Univ Turku, Turku, Finland Inst Univ Invest Atenc Primaria Jordi Gol, Girona, Spain Univ Putra Malaysia, Serdang, Malaysia Univ Malaya, Kuala Lumpur, Malaysia Sotiria Hosp, Athens, Greece Univ Valencia, Valencia, Spain Univ Philippines, Manila, Philippines Slovak Acad Sci, Bratislava, Slovakia Nutr Res Fdn, Barcelona, Spain Minas Gerais State Secretariat Hlth, Belo Horizonte, MG, Brazil CS S Agustin Ibsalut, Palma De Mallorca, Spain Amsterdam Inst Global Hlth & Dev, Amsterdam, Netherlands Natl Inst Hlth Doutor Ricardo Jorge, Lisbon, Portugal Univ Nove Julho, Sao Paulo, Brazil Publ Hlth Agcy Canada, Ottawa, ON, Canada Canarian Hlth Serv, Tenerife, Spain Univ Ind Santander, Bucaramanga, Colombia Assoc Calabrese Epatol, Reggio Di Calabria, Italy Univ Minho, Braga, Portugal Fiji Natl Univ, Suva, Fiji Spanish Nutr Fdn, Madrid, Spain Publ Hlth Agcy Sweden, Stockholm, Sweden Inst Food Sci Natl Res Council, Avellino, Italy Sitaram Bhartia Inst Sci & Res, New Delhi, India 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Bologna, Bologna, Italy Hellen Hlth Fdn, Athens, Greece Govt Med Coll, Bhavnagar, Gujarat, India Sefako Makgatho Hlth Sci Univ, Ga Rankuwa, South Africa Addis Ababa Univ, Addis Ababa, Ethiopia Minist Hlth, Wellington, New Zealand Univ Ctr Occidental Lisandro Alvarado, Barquisimeto, Venezuela Meharry Med Coll, Nashville, TN 37208 USA Dokuz Eylul Univ, Izmir, Turkey Univ Tampere, Tays Eye Ctr, Tampere, Finland Sabiha Gokcen Ilkokulu, Ankara, Turkey Polytech Inst Porto, Porto, Portugal Icahn Sch Med Mt Sinai, New York, NY 10029 USA Univ CEU San Pablo, Madrid, Spain CNR, Pisa, Italy Univ Miguel Hernandez, Alicante, Spain Vrije Univ Amsterdam, Amsterdam, Netherlands Sunflower Nursery Sch, Craiova, Romania North Karelia Ctr Publ Hlth, Joensuu, Finland Univ Witwatersrand, Johannesburg, South Africa Med Univ Vienna, Vienna, Austria Cork Inst Technol, Cork, Ireland Inst Med Res, Kuala Lumpur, Malaysia Xinjiang Med Univ, Urumqi, Peoples R China Shanghai Educ Dev Co Ltd, Shanghai, Peoples R China Minist Hlth, Auckland, New Zealand Rebro Univ, Rebro, Sweden St Georges Univ London, London, England Univ Indonesia, Jakarta, Indonesia Minist Agr & Rural Affairs, Inst Food & Nutr Dev, Beijing, Peoples R China Fudan Univ, Childrens Hosp, Shanghai, Peoples R China Univ Cyprus, Nicosia, Cyprus Niigata Univ, Niigata, Japan Int Med Univ, Shah Alam, Selangor, Malaysia Hellen Mediterranean Univ, Iraklion, Greece Iran Univ Med Sci, Tehran, Iran Ctr Diabet & Endocrine Care, Srinagar, India Peking Univ First Hosp, Beijing, Peoples R China Jiangsu Prov Ctr Dis Control & Prevent, Nanjing, Peoples R China Sun Yat Sen Univ, Guangzhou, Peoples R China West Kazakhstan Med Univ, Aktobe, Kazakhstan Inner Mongolia Med Univ, Hohhot, Peoples R China Przedszkole 81, Warsaw, Poland Univ Estadual Paulista, Presidente Prudente, Brazil

Published
2021

123. CISH and susceptibility to infectious diseases

Author

Khor, Chiea C., Vannberg, Fredrik O., Chapman, Stephen J., Haiyan Guo, Wong, Sunny H., Walley, Andrew J., Vukcevic, Damjan, Rautanen, Anna, Mills, Tara C., Kwok-Chiu Chang, Kai-Man Kam, Crampin, Amelia C., Ngwira, Bagrey, Chi-Chiu Leung, Cheuk-Ming Tam, Chiu-Yeung Chan, Sung, Joseph J.Y., Wing-Wai Yew, Kai-Yee Toh, Tay, Stacey K.H., Kwiatowski, Dominic, Lienhardt, Christian, Tran-Tinh Hien, Day, Nicholas P., Peshu, Nobert, Marsh, Kevin, Maitland, Kathryn, Scott, J. Anthony, Williams, Thomas N., Berkley, James A., Floyd, Sian, Tang, Nelson L.S., Fine, Paul E.M., Goh, Denise L.M., and Hill, Adrian V.S.

Subjects
Communicable diseases -- Genetic aspects, Communicable diseases -- Risk factors, Genetic polymorphisms -- Research, Disease susceptibility -- Evaluation
Abstract

The study attempts to evaluate the association, if any, between CISH polymorphisms and the susceptibility to infectious diseases. The results indicate that variants of CISH are associated with susceptibility to infectious disease and the overall risk of an infectious disease rose by nearly 18% in those carrying the variant CISH alleles.

Published
2010

124. Mortality trends in the era of antiretroviral therapy: evidence from the Network for Analysing Longitudinal Population based HIV/AIDS data on Africa (ALPHA)

Author

Reniers, Georges, Slaymaker, Emma, Nakiyingi-Miiro, Jessica, Nyamukapa, Constance, Crampin, Amelia Catharine, Herbst, Kobus, Urassa, Mark, Otieno, Fred, Gregson, Simon, Sewe, Maquins, Michael, Denna, Lutalo, Tom, Hosegood, Victoria, Kasamba, Ivan, Price, Alison, Nabukalu, Dorean, Mclean, Estelle, and Zaba, Basia

Published
2014
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127. Diagnosis of Childhood Tuberculosis and Host RNA Expression in Africa

Author

Anderson, Suzanne T., Kaforou, Myrsini, Brent, Andrew J., Wright, Victoria J., Banwell, Claire M., Chagaluka, George, Crampin, Amelia C., Dockrell, Hazel M., French, Neil, Hamilton, Melissa S., Hibberd, Martin L., Kern, Florian, Langford, Paul R., Ling, Ling, Mlotha, Rachel, Ottenhoff, Tom H.M., Pienaar, Sandy, Pillay, Vashini, Scott, J. Anthony G., Twahir, Hemed, Wilkinson, Robert J., Coin, Lachlan J., Heyderman, Robert S., Levin, Michael, and Eley, Brian

Published
2014
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128. Evaluation of Host Serum Protein Biomarkers of Tuberculosis in sub-Saharan Africa

Author

Morris, Thomas C, Hoggart, Clive J, Chegou, Novel N, Kidd, Martin, Oni, Tolu, Goliath, Rene, Wilkinson, Katalin A, Dockrell, Hazel M, Sichali, Lifted, Banda, Louis, Crampin, Amelia C, French, Neil, Walzl, Gerhard, Levin, Michael, Wilkinson, Robert J, Hamilton, Melissa S, and ILULU Consortium

Abstract

Accurate and affordable point-of-care diagnostics for tuberculosis (TB) are needed. Host serum protein signatures have been derived for use in primary care settings, however validation of these in secondary care settings is lacking. We evaluated serum protein biomarkers discovered in primary care cohorts from Africa reapplied to patients from secondary care. In this nested case-control study, concentrations of 22 proteins were quantified in sera from 292 patients from Malawi and South Africa who presented predominantly to secondary care. Recruitment was based upon intention of local clinicians to test for TB. The case definition for TB was culture positivity for Mycobacterium tuberculosis; and for other diseases (OD) a confirmed alternative diagnosis. Equal numbers of TB and OD patients were selected. Within each group, there were equal numbers with and without HIV and from each site. Patients were split into training and test sets for biosignature discovery. A nine-protein signature to distinguish TB from OD was discovered comprising fibrinogen, alpha-2-macroglobulin, CRP, MMP-9, transthyretin, complement factor H, IFN-gamma, IP-10, and TNF-alpha. This signature had an area under the receiver operating characteristic curve in the training set of 90% (95% CI 86-95%), and, after adjusting the cut-off for increased sensitivity, a sensitivity and specificity in the test set of 92% (95% CI 80-98%) and 71% (95% CI 56-84%), respectively. The best single biomarker was complement factor H [area under the receiver operating characteristic curve 70% (95% CI 64-76%)]. Biosignatures consisting of host serum proteins may function as point-of-care screening tests for TB in African hospitals. Complement factor H is identified as a new biomarker for such signatures.

Published
2021

129. Consequences of male partner engagement policies on HIV care-seeking in three African countries: Findings from the SHAPE UTT study

Author

Dube, Albert, Renju, Jenny, Wamoyi, Joyce, Hassan, Farida, Seeley, Janet, Chimukuche, Rujeko Samanthia, Songo, John, Kalua, Thokozani, Crampin, Amelia, Moshabela, Mosa, and Wringe, Alison

Abstract

We explored how strategies to promote male partner engagement influenced HIV care-seeking among men and women living with HIV. In-depth interviews were conducted with 25 health workers, 66 female service users and 10 male partners in Ifakara (Tanzania), Karonga (Malawi) and uMkhanyakude (South Africa) to elicit experiences of offering, providing or receiving HIV care in the context of antenatal care. Data were coded inductively and analysed thematically. Participants reported benefits of couple testing during antenatal care, including facilitated HIV status disclosure and mutual support for HIV care-seeking. However, unintended consequences included women attending without partners, being refused or delayed access to antenatal services. Some women were required to obtain letters from village leaders to justify the absence of their partners, again to delaying or disrupting care-seeking. When partners attended antenatal care, consultations were reportedly more likely to focus on HIV testing, and less on antenatal or neonatal care. Strategies to increase men's attendance at HIV clinics with their partners can promote mutual support within couples for HIV care engagement, but may risk undermining engagement in pregnancy and HIV care for some women if over-stringently applied. Efforts are needed to address the underlying pervasive stigma associated with HIV care, both alone and as a couple.

Published
2021

131. Worldwide trends in hypertension prevalence and progress in treatment and control from 1990 to 2019: a pooled analysis of 1201 population-representative studies with 104 million participants

Author

Zhou, Bin Carrillo-Larco, Rodrigo M. Danaei, Goodarz Riley, Leanne M. Paciorek, Christopher J. Stevens, Gretchen A. and Gregg, Edward W. Bennett, James E. Solomon, Bethlehem and Singleton, Rosie K. Sophiea, Marisa K. Iurilli, Maria L. C. and Lhoste, Victor P. F. Cowan, Melanie J. Savin, Stefan and Woodward, Mark Balanova, Yulia Cifkova, Renata Damasceno, Albertino Elliott, Paul Farzadfar, Farshad He, Jiang and Ikeda, Nayu Kengne, Andre P. Khang, Young-Ho Kim, Hyeon Chang Laxmaiah, Avula Lin, Hsien-Ho Margozzini Maira, Paula and Miranda, J. Jaime Neuhauser, Hannelore Sundstrom, Johan and Varghese, Cherian Widyahening, Indah S. Zdrojewski, Tomasz and Ezzati, Majid Abarca-Gomez, Leandra Abdeen, Ziad A. Rahim, Hanan F. Abdul Abu-Rmeileh, Niveen M. Acosta-Cazares, Benjamin and Adams, Robert J. Aekplakorn, Wichai Afsana, Kaosar and Afzal, Shoaib Agdeppa, Imelda A. Aghazadeh-Attari, Javad and Aguilar-Salinas, Carlos A. Agyemang, Charles Ahmad, Noor Ani and Ahmadi, Ali Ahmadi, Naser Ahmadi, Nastaran Ahmadizar, Fariba and Ahmed, Soheir H. Ahrens, Wolfgang Ajlouni, Kamel and Al-Raddadi, Rajaa Alarouj, Monira AlBuhairan, Fadia and AlDhukair, Shahla Ali, Mohamed M. Alkandari, Abdullah and Alkerwi, Ala'a Allin, Kristine Aly, Eman Amarapurkar, Deepak N. Amougou, Norbert Amouyel, Philippe Andersen, Lars Bo and Anderssen, Sigmund A. Anjana, Ranjit Mohan Ansari-Moghaddam, Alireza Ansong, Daniel Aounallah-Skhiri, Hajer Araujo, Joana and Ariansen, Inger Aris, Tahir Arku, Raphael E. Arlappa, Nimmathota Aryal, Krishna K. Aspelund, Thor Assah, Felix K. and Assuncao, Maria Cecilia F. Auvinen, Juha Avdicova, Maria and Azevedo, Ana Azimi-Nezhad, Mohsen Azizi, Fereidoun Azmin, Mehrdad Babu, Bontha V. Bahijri, Suhad Balakrishna, Nagalla and Balanova, Yulia Bamoshmoosh, Mohamed Banach, Maciej and Banadinovic, Maja Bandosz, Piotr Banegas, Jose R. Baran, Joanna Barbagallo, Carlo M. Barcelo, Alberto Barkat, Amina and Barreto, Marta Barros, Aluisio J. D. Gomes Barros, Mauro Virgilio Bartosiewicz, Anna Basit, Abdul Bastos, Joao Luiz D. Bata, Iqbal Batieha, Anwar M. Batyrbek, Assembekov and Baur, Louise A. Beaglehole, Robert Belavendra, Antonisamy and Ben Romdhane, Habiba Benet, Mikhail Bennett, James E. and Benson, Lowell S. Berkinbayev, Salim Bernabe-Ortiz, Antonio and Bettiol, Heloisa Bezerra, Jorge Bhagyalaxmi, Aroor Bhargava, Santosh K. Bia, Daniel Biasch, Katia Lele, Elysee Claude Bika Bikbov, Mukharram M. Bista, Bihungum Bjerregaard, Peter and Bjertness, Espen Bjertness, Marius B. Bjorkelund, Cecilia and Bloch, Katia V. Blokstra, Anneke Bo, Simona Bobak, Martin Boeing, Heiner Boggia, Jose G. Boissonnet, Carlos P. and Bojesen, Stig E. Bongard, Vanina Bonilla-Vargas, Alice and Bopp, Matthias Borghs, Herman Bovet, Pascal Boyer, Christopher B. Braeckman, Lutgart Brajkovich, Imperia and Branca, Francesco Breckenkamp, Juergen Brenner, Hermann and Brewster, Lizzy M. Briceno, Yajaira Brito, Miguel Bruno, Graziella Bueno-de-Mesquita, H. Bas Bueno, Gloria Bugge, Anna Burns, Con Bursztyn, Michael Cabrera de Leon, Antonio and Cacciottolo, Joseph Cameron, Christine Can, Gunay and Candido, Ana Paula C. Capanzana, Mario V. Capkova, Nadezda and Capuano, Eduardo Capuano, Vincenzo Cardoso, Viviane C. and Carlsson, Axel C. Carvalho, Joana Casanueva, Felipe F. and Censi, Laura Cervantes-Loaiza, Marvin Chadjigeorgiou, Charalambos A. Chamukuttan, Snehalatha Chan, Angelique W. and Chan, Queenie Chaturvedi, Himanshu K. Chaturvedi, Nish Chee, Miao Li Chen, Chien-Jen Chen, Fangfang Chen, Huashuai and Chen, Shuohua Chen, Zhengming Cheng, Ching-Yu Cheraghian, Bahman Dekkaki, Imane Cherkaoui Chetrit, Angela Chien, Kuo-Liong Chiolero, Arnaud Chiou, Shu-Ti Chirita-Emandi, Adela Chirlaque, Maria-Dolores Cho, Belong Christensen, Kaare Christofaro, Diego G. Chudek, Jerzy Cifkova, Renata and Cinteza, Eliza Claessens, Frank Clarke, Janine Clays, Els Cohen, Emmanuel Concin, Hans Cooper, Cyrus and Coppinger, Tara C. Costanzo, Simona Cottel, Dominique and Cowell, Chris Craig, Cora L. Crampin, Amelia C. Crujeiras, Ana B. Cruz, Juan J. Csilla, Semanova Cui, Liufu Cureau, Felipe V. Cuschieri, Sarah D'Arrigo, Graziella d'Orsi, Eleonora Dallongeville, Jean Damasceno, Albertino Danaei, Goodarz Dankner, Rachel Dantoft, Thomas M. Dauchet, Luc and Davletov, Kairat De Backer, Guy De Bacquer, Dirk De Curtis, Amalia de Gaetano, Giovanni De Henauw, Stefaan de Oliveira, Paula Duarte De Ridder, David De Smedt, Delphine Deepa, Mohan Deev, Alexander D. DeGennaro, Vincent Jr Delisle, Helene Demarest, Stefaan Dennison, Elaine Deschamps, Valerie and Dhimal, Meghnath Di Castelnuovo, Augusto F. Dias-da-Costa, Juvenal Soares Diaz, Alejandro Dickerson, Ty T. Dika, Zivka and Djalalinia, Shirin Do, Ha T. P. Dobson, Annette J. and Donfrancesco, Chiara Donoso, Silvana P. Doering, Angela and Dorobantu, Maria Doerr, Marcus Doua, Kouamelan Dragano, Nico and Drygas, Wojciech Duante, Charmaine A. Duboz, Priscilla and Duda, Rosemary B. Dulskiene, Virginija Dushpanova, Anar and Dzakula, Aleksandar Dzerve, Vilnis Dziankowska-Zaborszczyk, Elzbieta Eddie, Ricky Eftekhar, Ebrahim Eggertsen, Robert and Eghtesad, Sareh Eiben, Gabriele Ekelund, Ulf El-Khateeb, Mohammad El Ati, Jalila Eldemire-Shearer, Denise Eliasen, Marie Elliott, Paul Elosua, Roberto Erasmus, Rajiv T. and Erbel, Raimund Erem, Cihangir Eriksen, Louise Eriksson, Johan G. Escobedo-de la Pena, Jorge Eslami, Saeid Esmaeili, Ali Evans, Alun Faeh, David Fakhretdinova, Albina A. and Fall, Caroline H. Faramarzi, Elnaz Farjam, Mojtaba and Farzadfar, Farshad Fattahi, Mohammad Reza Fawwad, Asher and Felix-Redondo, Francisco J. Felix, Stephan B. Ferguson, Trevor S. Fernandes, Romulo A. Fernandez-Berges, Daniel Ferrante, Daniel Ferrao, Thomas Ferrari, Marika Ferrario, Marco M. and Ferreccio, Catterina Ferreira, Haroldo S. Ferrer, Eldridge and Ferrieres, Jean Figueiro, Thamara Hubler Fink, Gunther and Fischer, Krista Foo, Leng Huat Forsner, Maria Fouad, Heba M. and Francis, Damian K. Franco, Maria do Carmo Frikke-Schmidt, Ruth Frontera, Guillermo Fuchs, Flavio D. Fuchs, Sandra C. and Fujita, Yuki Fumihiko, Matsuda Furdela, Viktoriya Furer, Ariel Furusawa, Takuro Gaciong, Zbigniew Galbarczyk, Andrzej and Galenkamp, Henrike Galvano, Fabio Gao, Jingli Gao, Pei and Garcia-de-la-Hera, Manoli Garcia, Pablo Gareta, Dickman and Garnett, Sarah P. Gaspoz, Jean-Michel Gasull, Magda and Gazzinelli, Andrea Gehring, Ulrike Geleijnse, Johanna M. and George, Ronnie Ghanbari, Ali Ghasemi, Erfan Gheorghe-Fronea, Oana-Florentina Ghimire, Anup Gialluisi, Alessandro and Giampaoli, Simona Gieger, Christian Gill, Tiffany K. and Giovannelli, Jonathan Gironella, Glen Giwercman, Aleksander and Gkiouras, Konstantinos Goldberg, Marcel Goldsmith, Rebecca A. and Gomez, Luis F. Gomula, Aleksandra Cordeiro da Silva, Bruna Goncalves Goncalves, Helen Goncalves, Mauer Gonzalez-Chica, David A. Gonzalez-Gross, Marcela Gonzalez-Rivas, Juan P. and Gonzalez-Villalpando, Clicerio Gonzalez-Villalpando, Maria-Elena and Gonzalez, Angel R. Bonet Gorbea, Mariano Gottrand, Frederic and Graff-Iversen, Sidsel Grafnetter, Dusan Grajda, Aneta and Grammatikopoulou, Maria G. Gregor, Ronald D. Grodzicki, Tomasz and Grosso, Giuseppe Gruden, Gabriella Gu, Dongfeng Guan, Ong Peng Gudmundsson, Elias F. Gudnason, Vilmundur Guerrero, Ramiro Guessous, Idris Guimaraes, Andre L. Gulliford, Martin C. Gunnlaugsdottir, Johanna Gunter, Marc J. Gupta, Prakash C. Gupta, Rajeev Gureje, Oye Gurzkowska, Beata and Gutierrez, Laura Gutzwiller, Felix Ha, Seongjun Hadaegh, Farzad Haghshenas, Rosa Hakimi, Hamid Halkjaer, Jytte and Hambleton, Ian R. Hamzeh, Behrooz Hange, Dominique Hanif, Abu A. M. Hantunen, Sari Hao, Jie Hardman, Carla Meneses and Kumar, Rachakulla Hari Hashemi-Shahri, Seyed Mohammad Hata, Jun and Haugsgjerd, Teresa Hayes, Alison J. He, Jiang He, Yuna and Heier, Margit Hendriks, Marleen Elisabeth Henrique, Rafael dos Santos Henriques, Ana Cadena, Leticia Hernandez Herrala, Sauli Heshmat, Ramin Hill, Allan G. Ho, Sai Yin Ho, Suzanne C. Hobbs, Michael Holdsworth, Michelle Homayounfar, Reza Dinc, Gonul Horasan Horimoto, Andrea R. V. R. Hormiga, Claudia M. Horta, Bernardo L. Houti, Leila Howitt, Christina and Htay, Thein Thein Htet, Aung Soe Htike, Maung Maung Than and Hu, Yonghua Huerta, Jose Maria Huhtaniemi, Ilpo Tapani and Huiart, Laetitia Huisman, Martijn Husseini, Abdullatif S. and Huybrechts, Inge Hwalla, Nahla Iacoviello, Licia Iannone, Anna G. Ibrahim, Mohsen M. Wong, Norazizah Ibrahim Ikeda, Nayu Ikram, M. Arfan Iotova, Violeta Irazola, Vilma E. and Ishida, Takafumi Isiguzo, Godsent C. Islam, Muhammad Islam, Sheikh Mohammed Shariful Iwasaki, Masanori Jackson, Rod T. and Jacobs, Jeremy M. Jaddou, Hashem Y. Jafar, Tazeen James, Kenneth Jamrozik, Konrad Janszky, Imre Janus, Edward and Jarvelin, Marjo-Riitta Jasienska, Grazyna Jelakovic, Ana and Jelakovic, Bojan Jennings, Garry Jha, Anjani Kumar Jiang, Chao Qiang Jimenez, Ramon O. Joeckel, Karl-Heinz Joffres, Michel Johansson, Mattias Jokelainen, Jari J. Jonas, Jost B. and Jorgensen, Torben Joshi, Pradeep Joukar, Farahnaz and Jozwiak, Jacek Juolevi, Anne Jurak, Gregor Juresa, Vesna and Kaaks, Rudolf Kafatos, Anthony Kajantie, Eero O. and Kalmatayeva, Zhanna Kalpourtzi, Natasa Kalter-Leibovici, Ofra and Kampmann, Freja B. Kannan, Srinivasan Karaglani, Eva and Karhus, Line L. Karki, Khem B. Katibeh, Marzieh Katz, Joanne and Kauhanen, Jussi Kaur, Prabhdeep Kavousi, Maryam and Kazakbaeva, Gyulli M. Keil, Ulrich Boker, Lital Keinan and Keinanen-Kiukaanniemi, Sirkka Kelishadi, Roya Kemper, Han C. G. and Kengne, Andre P. Keramati, Maryam Kerimkulova, Alina and Kersting, Mathilde Key, Timothy Khader, Yousef Saleh and Khalili, Davood Khang, Young-Ho Khaw, Kay-Tee Kheiri, Bahareh Kheradmand, Motahareh Khosravi, Alireza and Kiechl-Kohlendorfer, Ursula Kiechl, Stefan Killewo, Japhet and Kim, Dong Wook Kim, Hyeon Chang Kim, Jeongseon Klakk, Heidi and Klimek, Magdalena Klumbiene, Jurate Knoflach, Michael and Kolle, Elin Kolsteren, Patrick Kontto, Jukka P. Korpelainen, Raija Korrovits, Paul Kos, Jelena Koskinen, Seppo Kouda, Katsuyasu Kowlessur, Sudhir Koziel, Slawomir Kratenova, Jana and Kriaucioniene, Vilma Kristensen, Peter Lund Krokstad, Steiner Kromhout, Daan Kruger, Herculina S. Kubinova, Ruzena and Kuciene, Renata Kujala, Urho M. Kulaga, Zbigniew Kumar, R. Krishna Kurjata, Pawel Kusuma, Yadlapalli S. Kutsenko, Vladimir Kuulasmaa, Kari Kyobutungi, Catherine Laatikainen, Tiina Lachat, Carl Laid, Youcef Lam, Tai Hing Landrove, Orlando Lanska, Vera Lappas, Georg Larijani, Bagher and Latt, Tint Swe Laxmaiah, Avula Le Coroller, Gwenaelle Khanh Le Nguyen Bao Le, Tuyen D. Lee, Jeannette Lee, Jeonghee and Lehmann, Nils Lehtimaki, Terho Lemogoum, Daniel Levitt, Naomi S. Li, Yanping Lilly, Christa L. Lim, Wei-Yen and Lima-Costa, M. Fernanda Lin, Hsien-Ho Lin, Xu Lin, Yi-Ting and Lind, Lars Lingam, Vijaya Linneberg, Allan Lissner, Lauren Litwin, Mieczyslaw Lo, Wei-Cheng Loit, Helle-Mai and Lopez-Garcia, Esther Lopez, Tania Lotufo, Paulo A. Lozano, Jose Eugenio Lovrencic, Iva Lukacevic Lukrafka, Janice L. and Luksiene, Dalia Lundqvist, Annamari Lundqvist, Robert Lunet, Nuno Lustigova, Michala Luszczki, Edyta Ma, Guansheng and Ma, Jun Machado-Coelho, George L. L. Machado-Rodrigues, Aristides M. Macia, Enguerran Macieira, Luisa M. Madar, Ahmed A. Maggi, Stefania Magliano, Dianna J. Magriplis, Emmanuella Mahasampath, Gowri Maire, Bernard Majer, Marjeta and Makdisse, Marcia Malekzadeh, Fatemeh Malekzadeh, Reza and Malhotra, Rahul Mallikharjuna, Kodavanti Malyutina, Sofia K. and Maniego, Lynell V. Manios, Yannis Mann, Jim I. and Mansour-Ghanaei, Fariborz Manzato, Enzo Marcil, Anie and Margozzini, Paula Marild, Staffan B. Glavic, Mihalea Marinovic and Marques-Vidal, Pedro Marques, Larissa Pruner Marrugat, Jaume and Martorell, Reynaldo Mascarenhas, Luis P. Matasin, Marija and Mathiesen, Ellisiv B. Mathur, Prashant Matijasevich, Alicia and Matlosz, Piotr Matsha, Tandi E. Mavrogianni, Christina and Mbanya, Jean Claude N. Mc Donald Posso, Anselmo J. McFarlane, Shelly R. McGarvey, Stephen T. McLachlan, Stela McLean, Rachael M. McLean, Scott B. McNulty, Breige A. Benchekor, Sounnia Mediene Medzioniene, Jurate Mehdipour, Parinaz and Mehlig, Kirsten Mehrparvar, Amir Houshang Meirhaeghe, Aline and Meisinger, Christa Mendoza Montano, Carlos Menezes, Ana Maria B. and Menon, Geetha R. Mereke, Alibek Meshram, Indrapal I. and Metspalu, Andres Meyer, Haakon E. Mi, Jie Michels, Nathalie and Mikkel, Kairit Milkowska, Karolina Miller, Jody C. and Minderico, Claudia S. Mini, G. K. Miranda, J. Jaime and Mirjalili, Mohammad Reza Mirrakhimov, Erkin Misigoj-Durakovic, Marjeta Modesti, Pietro A. Moghaddam, Sahar Saeedi Mohajer, Bahram Mohamed, Mostafa K. Mohamed, Shukri F. Mohammad, Kazem Mohammadi, Mohammad Reza Mohammadi, Zahra and Mohammadifard, Noushin Mohammadpourhodki, Reza Mohan, Viswanathan Mohanna, Salim Yusoff, Muhammad Fadhli Mohd and Mohebbi, Iraj Mohebi, Farnam Moitry, Marie Mollehave, Line T. Molnar, Denes Momenan, Amirabbas Mondo, Charles K. and Monterrubio-Flores, Eric Monyeki, Kotsedi Daniel K. Moon, Jin Soo Moosazadeh, Mahmood Moreira, Leila B. Morejon, Alain and Moreno, Luis A. Morgan, Karen Moschonis, George Mossakowska, Malgorzata Mostafa, Aya Mostafavi, Seyed-Ali Mota, Jorge and Motlagh, Mohammad Esmaeel Motta, Jorge Andre Moura-dos-Santos, Marcos Mridha, Malay K. Msyamboza, Kelias P. Mu, Thet Thet and Muhihi, Alfa J. Muiesan, Maria L. Muller-Nurasyid, Martina and Murphy, Neil Mursu, Jaakko Musa, Kamarul Imran and Milanovic, Sanja Music Musil, Vera Mustafa, Norlaila and Nabipour, Iraj Naderimagham, Shohreh Nagel, Gabriele Naidu, Balkish M. Najafi, Farid Nakamura, Harunobu Namesna, Jana and Nang, Ei Ei K. Nangia, Vinay B. Narake, Sameer Ndiaye, Ndeye Coumba Neal, William A. Nejatizadeh, Azim Nenko, Ilona and Neovius, Martin Neuhauser, Hannelore K. Nguyen, Chung T. and Nguyen, Nguyen D. Nguyen, Quang V. Quang Ngoc Nguyen and Nieto-Martinez, Ramfis E. Niiranen, Teemu J. Nikitin, Yury P. and Ninomiya, Toshiharu Nishtar, Sania Njelekela, Marina A. and Noale, Marianna Noboa, Oscar A. Noorbala, Ahmad Ali Norat, Teresa Nordendahl, Maria Nordestgaard, Borge G. Noto, Davide and Nowak-Szczepanska, Natalia Al Nsour, Mohannad Nunes, Baltazar O'Neill, Terence W. O'Reilly, Dermot Ochimana, Caleb Oda, Eiji Odili, Augustine N. Oh, Kyungwon Ohara, Kumiko Ohtsuka, Ryutaro Olie, Valerie Olinto, Maria Teresa A. Oliveira, Isabel O. Omar, Mohd Azahadi Onat, Altan and Ong, Sok King Ono, Lariane M. Ordunez, Pedro Ornelas, Rui and Ortiz, Pedro J. Osmond, Clive Ostojic, Sergej M. and Ostovar, Afshin Otero, Johanna A. Overvad, Kim Owusu-Dabo, Ellis Paccaud, Fred Michel Padez, Cristina Pahomova, Elena and de Paiva, Karina Mary Pajak, Andrzej Palli, Domenico and Palmieri, Luigi Pan, Wen-Harn Panda-Jonas, Songhomitra and Panza, Francesco Paoli, Mariela Papandreou, Dimitrios Park, Soon-Woo Park, Suyeon Parnell, Winsome R. Parsaeian, Mahboubeh Pasquet, Patrick Patel, Nikhil D. Pavlyshyn, Halyna Pecin, Ivan Pednekar, Mangesh S. Pedro, Joao M. and Peer, Nasheeta Peixoto, Sergio Viana Peltonen, Markku and Pereira, Alexandre C. Peres, Karen G. D. A. Peres, Marco A. and Peters, Annette Petkeviciene, Janina Peykari, Niloofar Son Thai Pham Pichardo, Rafael N. Pigeot, Iris Pikhart, Hynek and Pilav, Aida Pilotto, Lorenza Pitakaka, Freda Piwonska, Aleksandra Pizarro, Andreia N. Plans-Rubio, Pedro Polasek, Ozren Porta, Miquel Poudyal, Anil Pourfarzi, Farhad and Pourshams, Akram Poustchi, Hossein Pradeepa, Rajendra Price, Alison J. Price, Jacqueline F. Providencia, Rui Puhakka, Soile E. Puiu, Maria Punab, Margus Qasrawi, Radwan F. and Qorbani, Mostafa Queiroz, Daniel Tran Quoc Bao Radic, Ivana and Radisauskas, Ricardas Rahimikazerooni, Salar Rahman, Mahfuzar Raitakari, Olli Raj, Manu Rakhimova, Ellina M. and Rao, Sudha Ramachandra Ramachandran, Ambady Ramos, Elisabete and Rampal, Lekhraj Rampal, Sanjay Rangel Reina, Daniel A. and Rarra, Vayia Rech, Cassiano Ricardo Redon, Josep Reganit, Paul Ferdinand M. Regecova, Valeria Revilla, Luis and Rezaianzadeh, Abbas Ribeiro, Robespierre Riboli, Elio and Richter, Adrian Rigo, Fernando de Wit, Tobias F. Rinke and Ritti-Dias, Raphael M. Robitaille, Cynthia Rodriguez-Artalejo, Fernando del Cristo Rodriguez-Perez, Maria Rodriguez-Villamizar, Laura A. Roggenbuck, Ulla Rojas-Martinez, Rosalba Romaguera, Dora Romeo, Elisabetta L. Rosengren, Annika Roy, Joel G. R. and Rubinstein, Adolfo Ruidavets, Jean-Bernard Sandra Ruiz-Betancourt, Blanca Ruiz-Castell, Maria Rusakova, Iuliia A. and Russo, Paola Rutkowski, Marcin Sabanayagam, Charumathi and Sabbaghi, Hamideh Sachdev, Harshpal S. Sadjadi, Alireza and Safarpour, Ali Reza Safi, Sare Safiri, Saeid Saidi, Olfa and Sakarya, Sibel Saki, Nader Salanave, Benoit Salazar Martinez, Eduardo Salmeron, Diego Salomaa, Veikko Salonen, Jukka T. Salvetti, Massimo Sanchez-Abanto, Jose Sans, Susana and Santos, Diana A. Santos, Ina S. Santos, Lelita C. and Santos, Maria Paula Santos, Rute Saramies, Jouko L. and Sardinha, Luis B. Sarganas, Giselle Sarrafzadegan, Nizal and Sathish, Thirunavukkarasu Saum, Kai-Uwe Savva, Savvas and Sawada, Norie Sbaraini, Mariana Scazufca, Marcia Schaan, Beatriz D. Schargrodsky, Herman Schipf, Sabine Schmidt, Carsten O. Schnohr, Peter Schoettker, Ben Schramm, Sara and Schultsz, Constance Schutte, Aletta E. Sebert, Sylvain Sein, Aye Aye Sen, Abhijit Senbanjo, Idowu O. Sepanlou, Sadaf G. and Servais, Jennifer Shalnova, Svetlana A. Shamah-Levy, Teresa and Shamshirgaran, Morteza Shanthirani, Coimbatore Subramaniam and Sharafkhah, Maryam Sharma, Sanjib K. Shaw, Jonathan E. and Shayanrad, Amaneh Shayesteh, Ali Akbar Shi, Zumin Shibuya, Kenji Shimizu-Furusawa, Hana Shin, Dong Wook Shirani, Majid and Shiri, Rahman Shrestha, Namuna Si-Ramlee, Khairil Siani, Alfonso Siantar, Rosalynn Sibai, Abla M. de Moura Silva, Caroline Ramos Santos Silva, Diego Augusto Simon, Mary and Simons, Judith Simons, Leon A. Sjostrom, Michael and Slowikowska-Hilczer, Jolanta Slusarczyk, Przemyslaw Smeeth, Liam and So, Hung-Kwan Soares, Fernanda Cunha Sobngwi, Eugene and Soderberg, Stefan Soemantri, Agustinus Sofat, Reecha and Solfrizzi, Vincenzo Somi, Mohammad Hossein Sonestedt, Emily and Song, Yi Sorensen, Thorkild I. A. Sorgjerd, Elin P. Soric, Maroje Jerome, Charles Sossa Soumare, Aicha Sparboe-Nilsen, Bente Sparrenberger, Karen Staessen, Jan A. Starc, Gregor and Stavreski, Bill Steene-Johannessen, Jostein Stehle, Peter and Stein, Aryeh D. Stergiou, George S. Stessman, Jochanan and Stieber, Jutta Stoeckl, Doris Stocks, Tanja Stokwiszewski, Jakub Stronks, Karien Strufaldi, Maria Wany Suka, Machi and Sun, Chien-An Sundstrom, Johan Sung, Yn-Tz Suriyawongpaisal, Paibul Sy, Rody G. Syddall, Holly E. Sylva, Rene Charles and Szklo, Moyses Tai, E. Shyong Tammesoo, Mari-Liis Tamosiunas, Abdonas Tan, Eng Joo Tang, Xun Tanser, Frank Tao, Yong and Tarawneh, Mohammed Rasoul Tarqui-Mamani, Carolina B. Taylor, Anne Taylor, Julie Tebar, William R. Tell, Grethe S. and Tello, Tania Tham, Yih Chung Thankappan, K. R. Theobald, Holger Theodoridis, Xenophon Thijs, Lutgarde Thinggaard, Mikael Thomas, Nihal Thorand, Barbara Thuesen, Betina H. and Timmermans, Erik J. Tjandrarini, Dwi H. Tjonneland, Anne and Toft, Ulla Tolonen, Hanna K. Tolstrup, Janne S. Topbas, Murat Topor-Madry, Roman Jose Tormo, Maria Tornaritis, Michael J. Torrent, Maties Torres-Collado, Laura Touloumi, Giota Traissac, Pierre Triantafyllou, Areti Trichopoulos, Dimitrios Trichopoulou, Antonia Trinh, Oanh T. H. Trivedi, Atul Tshepo, Lechaba Tsugane, Shoichiro Tuliakova, Azaliia M. Tulloch-Reid, Marshall K. Tullu, Fikru Tuomainen, Tomi-Pekka Tuomilehto, Jaakko Turley, Maria L. Twig, Gilad and Tynelius, Per Tzourio, Christophe Ueda, Peter Ugel, Eunice Ulmer, Hanno Uusitalo, Hannu M. T. Valdivia, Gonzalo and Valvi, Damaskini van Dam, Rob M. van den Born, Bert-Jan and Van der Heyden, Johan van der Schouw, Yvonne T. Van Herck, Koen and Hoang Van Minh Van Schoor, Natasja M. van Valkengoed, Irene G. M. van Zutphen, Elisabeth M. Vanderschueren, Dirk and Vanuzzo, Diego Varbo, Anette Vasan, Senthil K. Vega, Tomas and Veidebaum, Toomas Velasquez-Melendez, Gustavo Veronesi, Giovanni Verschuren, W. M. Monique Verstraeten, Roosmarijn and Victora, Cesar G. Viet, Lucie Villalpando, Salvador Vineis, Paolo Vioque, Jesus Virtanen, Jyrki K. Visvikis-Siest, Sophie Viswanathan, Bharathi Vlasoff, Tiina Vollenweider, Peter Voutilainen, Ari Wade, Alisha N. Walton, Janette and Wambiya, Elvis O. A. Bebakar, Wan Mohamad Wan Mohamud, Wan Nazaimoon Wan Wanderley Junior, Rildo de Souza Wang, Ming-Dong and Wang, Ningli Wang, Qian Wang, Xiangjun Wang, Ya Xing and Wang, Ying-Wei Wannamethee, S. Goya Wareham, Nicholas Wei, Wenbin Weres, Aneta Werner, Bo Whincup, Peter H. and Widhalm, Kurt Widyahening, Indah S. Wiecek, Andrzej Wilks, Rainford J. Willeit, Johann Willeit, Peter Williams, Emmanuel A. Wilsgaard, Tom Wojtyniak, Bogdan Wong-McClure, Roy A. Wong, Andrew Wong, Tien Yin Woo, Jean Woodward, Mark Wu, Frederick C. Wu, Shouling Wyszynska, Justyna and Xu, Haiquan Xu, Liang Yaacob, Nor Azwany Yan, Weili and Yang, Ling Yang, Xiaoguang Yang, Yang Yasuharu, Tabara and Ye, Xingwang Yiallouros, Panayiotis K. Yoosefi, Moein and Yoshihara, Akihiro You, San-Lin Younger-Coleman, Novie O. and Yusoff, Ahmad Faudzi Zainuddin, Ahmad A. Zakavi, Seyed Rasoul and Zamani, Farhad Zambon, Sabina Zampelas, Antonis Elisa Zapata, Maria Zaw, Ko Ko Zdrojewski, Tomasz Zejglicova, Kristyna Vrkic, Tajana Zeljkovic Zeng, Yi Zhang, Luxia and Zhang, Zhen-Yu Zhao, Dong Zhao, Ming-Hui Zhen, Shiqi and Zheng, Yingfeng Zholdin, Bekbolat Zhu, Dan Zins, Marie and Zitt, Emanuel Zocalo, Yanina Zoghlami, Nada Zuniga Cisneros, Julio NCD Risk Factor Collaboration

Abstract

Background Hypertension can be detected at the primary health-care level and low-cost treatments can effectively control hypertension. We aimed to measure the prevalence of hypertension and progress in its detection, treatment, and control from 1990 to 2019 for 200 countries and territories. Methods We used data from 1990 to 2019 on people aged 30-79 years from population-representative studies with measurement of blood pressure and data on blood pressure treatment. We defined hypertension as having systolic blood pressure 140 mm Hg or greater, diastolic blood pressure 90 mm Hg or greater, or taking medication for hypertension. We applied a Bayesian hierarchical model to estimate the prevalence of hypertension and the proportion of people with hypertension who had a previous diagnosis (detection), who were taking medication for hypertension (treatment), and whose hypertension was controlled to below 140/90 mm Hg (control). The model allowed for trends over time to be non-linear and to vary by age. Findings The number of people aged 30-79 years with hypertension doubled from 1990 to 2019, from 331 (95% credible interval 306-359) million women and 317 (292-344) million men in 1990 to 626 (584-668) million women and 652 (604-698) million men in 2019, despite stable global age-standardised prevalence. In 2019, age-standardised hypertension prevalence was lowest in Canada and Peru for both men and women; in Taiwan, South Korea, Japan, and some countries in western Europe including Switzerland, Spain, and the UK for women; and in several low-income and middle-income countries such as Eritrea, Bangladesh, Ethiopia, and Solomon Islands for men. Hypertension prevalence surpassed 50% for women in two countries and men in nine countries, in central and eastern Europe, central Asia, Oceania, and Latin America. Globally, 59% (55-62) of women and 49% (46-52) of men with hypertension reported a previous diagnosis of hypertension in 2019, and 47% (43-51) of women and 38% (35-41) of men were treated. Control rates among people with hypertension in 2019 were 23% (20-27) for women and 18% (16-21) for men. In 2019, treatment and control rates were highest in South Korea, Canada, and Iceland (treatment >70%; control >50%), followed by the USA, Costa Rica, Germany, Portugal, and Taiwan. Treatment rates were less than 25% for women and less than 20% for men in Nepal, Indonesia, and some countries in sub-Saharan Africa and Oceania. Control rates were below 10% for women and men in these countries and for men in some countries in north Africa, central and south Asia, and eastern Europe. Treatment and control rates have improved in most countries since 1990, but we found little change in most countries in sub-Saharan Africa and Oceania. Improvements were largest in high-income countries, central Europe, and some upper-middle-income and recently high-income countries including Costa Rica, Taiwan, Kazakhstan, South Africa, Brazil, Chile, Turkey, and Iran. Interpretation Improvements in the detection, treatment, and control of hypertension have varied substantially across countries, with some middle-income countries now outperforming most high-income nations. The dual approach of reducing hypertension prevalence through primary prevention and enhancing its treatment and control is achievable not only in high-income countries but also in low-income and middle-income settings. Copyright (C) 2021 World Health Organization; licensee Elsevier.

Published
2021

132. Additional file 1 of Intervention development of a brief messaging intervention for a randomised controlled trial to improve diabetes treatment adherence in sub-Saharan Africa

Author

Leon, Natalie, Namadingo, Hazel, Bobrow, Kirsty, Cooper, Sara, Crampin, Amelia, Pauly, Bruno, Levitt, Naomi, and Farmer, Andrew

Abstract

Additional file 1: Interview guide. Interview guide used for the in-depth individual interviews and focus groups with patient participants in Phase 1.

Published
2021
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133. Additional file 1 of Community-driven citizen science approach to explore cardiovascular disease risk perception, and develop prevention advocacy strategies in sub-Saharan Africa: a programme protocol

Author

Okop, Kufre Joseph, Murphy, Kathy, Lambert, Estelle Victoria, Kiya Kedir, Hailemichael Getachew, Rawleigh Howe, Niyibizi, Jean Berchmans, Selemani Ntawuyirushintege, Bavuma, Charlotte, Rulisa, Stephen, Kasenda, Stephen, Chipeta, Effie, Bunn, Christopher, Crampin, Amelia C., Chapotera, Gertrude, King, Abby C., Banchoff, Ann, Winter, Sandra J., and Levitt, Naomi S.

Abstract

Additional file 1. Ethiopia Administrative and Public Health System overview (Example of country administrative structure and public health system)

Published
2021
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135. Determinants of cluster size in large, population-based molecular epidemiology study of tuberculosis, Northern Malawi

Author

Glynn, Judith R., Crampin, Amelia C., Traore, Hamidou, Chaguluka, Steve, Mwafulirwa, Donex T., Alghamdi, Saad, Ngwira, Bagrey M.M., Yates, Malcolm D., Drobniewski, Francis D., and Fine, Paul E.M.

Subjects
Company distribution practices, Mycobacterium tuberculosis -- Health aspects, Mycobacterium tuberculosis -- Distribution, Tuberculosis -- Risk factors, Tuberculosis -- Diagnosis, Tuberculosis -- Distribution, Tuberculosis -- Control, Epidemiology -- Methods, Epidemiology -- Analysis
Abstract

Tuberculosis patients with identical strains of Mycobacterium tuberculosis are described as clustered. Cluster size may depend on patient or strain characteristics. In a 7-year population-based study of tuberculosis in Karonga [...]

Published
2008

136. Pneumonia and exposure to household air pollution in children under the age of 5 in rural Malawi: findings from the Cooking And Pneumonia Study (CAPS)

Author

Mortimer, Kevin, Lesosky, Maia, Semple, Sean, Malava, ulita, Katundu, Cynthia, Crampin, Amelia, Wang, Duolao, Weston, William, Pope, Dan, Havens, Deborah, Gordon, Stephen, and Balmes, John

Subjects
wa_754, wa_395, wc_202, ws_440
Abstract

BACKGROUND:\ud Exposure to household air pollution is associated with an increased risk of pneumonia in children in low- and middle-income countries, however exposure-response data are limited and there are uncertainties around the extent to which biomass-fueled cookstoves can reduce these exposures.\ud RESEARCH QUESTION:\ud What is the association between exposure to household air pollution and pneumonia in children under the age of 5 years in rural Malawi and what are the effects of a biomass-fueled cookstove intervention on personal exposure to household air pollution?\ud \ud STUDY DESIGN:\ud and methods We measured personal exposure to carbon monoxide (CO) [48 hours of continuous measurement and transcutaneous carboxyhemoglobin (COHb)] 6-monthly in children participating in a cluster-randomised controlled trial of a cleaner-burning biomass-fueled cookstove intervention to prevent pneumonia in children under the age of 5 years in rural Malawi - the Cooking And Pneumonia Study (CAPS). Exposure-response and multi-variable analyses were done.\ud RESULTS:\ud We recruited 1805 (928 intervention; 877 control) children (mean age 25.6 months, 50.6% female). We found no evidence of an association between exposure to CO (IRR=1.0 95% CI:0.967-1.014; p=0.53) or COHb (IRR=1.00 95% CI:0.993-1.003; p=0.41)) in children who experienced pneumonia versus those who did not. Median exposure to CO in the intervention and control groups was was 0.34 ppm (IQR 0.15-0.81) and 0.37 ppm (IQR 0.15-0.97), respectively. The group difference in means was 0.46 (95% CI:-0.95-0.012; p=0.06).\ud \ud INTERPRETATION:\ud Exposure to CO in our population was low with no association seen between exposure to CO and pneumonia incidence and no effect of the CAPS intervention on these exposures. These findings suggest that CO may not be an appropriate measure of household air pollution exposure in settings like rural Malawi and that there is a need to develop ways to directly measure particulate matter exposures in young children instead.\ud CLINICAL TRIAL REGISTRATION NUMBER:\ud ISRCTN59448623.

Published
2020

137. Implications of HIV treatment policies on the health workforce in rural Malawi and Tanzania between 2013 and 2017: Evidence from the SHAPE-UTT study

Author

Songo, John, Wringe, Alison, Hassan, Farida, McLean, Estelle, Vyas, Seema, Dube, Albert, Luwanda, Lameck, Kalua, Thokozani, Kajoka, Deborah, Crampin, Amelia, Todd, Jim, Schouten, Erik, Seeley, Janet, Geubbels, Eveline, and Renju, Jenny

Abstract

Effective implementation of policies for expanding antiretroviral therapy (ART) requires a well-trained and adequately staffed workforce. Changes in national HIV workforce policies, health facility practices, and provider experiences were examined in rural Malawi and Tanzania between 2013 and 2017.\ud \ud In both countries, task-shifting and task-sharing policies were explicit by 2013. In facilities, the cadre mix of providers varied by site and changed over time, with a higher and growing proportion of lower cadre staff in the Malawi site. In Malawi, the introduction of lay counsellors was perceived to have eased the workload of other providers, but lay counsellors reported inadequate support. Both countries had guidance on the minimum numbers of personnel required to deliver HIV services. However, patient loads per provider increased in both settings for HIV tests and visits by ART patients and were not met with corresponding increases in provider capacity in either setting. Providers reported this as a challenge.\ud \ud Although increasing patient numbers bodes well for achieving universal antiretroviral therapy coverage, the quality of care may be undermined by increased workloads and insufficient provider training. Task-shifting strategies may help address workload concerns, but require careful monitoring, supervision and mentoring to ensure effective implementation.

Published
2020

138. Identifying gaps in HIV service delivery across the diagnosis-to-treatment cascade: findings from health facility surveys in six sub-Saharan countries

Author

Church, Kathryn, Machiyama, Kazuyo, Todd, Jim, Njamwea, Brian, Mwangome, Mary, Hosegood, Vicky, Michel, Janet, Oti, Samuel, Nyamukapa, Constance, Crampin, Amelia, Amek, Nyaguara, Nakigozi, Gertrude, Michael, Denna, Gomez-Olive, F.Xavier, Nakiyingi-Miiro, Jessica, Zaba, Basia, and Wringe, Alison

Subjects
Management, Care and treatment, Usage, Patient outcomes, Dosage and administration, Company business management, HIV infections -- Care and treatment -- Patient outcomes, HIV tests -- Usage -- Health aspects -- Surveys, Medical care -- Management -- Sub-Saharan Africa, Antiretroviral agents -- Health aspects -- Surveys -- Dosage and administration
Abstract

Introduction In 2015 in Eastern and Southern Africa, 10.3 million people were accessing antiretroviral therapy (ART), representing an estimated 54% [50-58%] of all people living with HIV (PLHIV) in the [...], Introduction: Despite the rollout of antiretroviral therapy (ART), challenges remain in ensuring timely access to care and treatment for people living with HIV. As part of a multi-country study to investigate HIV mortality, we conducted health facility surveys within 10 health and demographic surveillance system sites across six countries in Eastern and Southern Africa to investigate clinic-level factors influencing (i) use of HIV testing services, (ii) use of HIV care and treatment and (iii) patient retention on ART. Methods: Health facilities (n = 156) were sampled within 10 surveillance sites: Nairobi and Kisumu (Kenya), Karonga (Malawi), Agincourt and uMkhanyakude (South Africa), Ifakara and Kisesa (Tanzania), Kyamulibwa and Rakai (Uganda) and Manicaland (Zimbabwe). Structured questionnaires were administered to in-charge staff members of HIV testing, prevention of mother-to-child transmission (PMTCT) and ART units within the facilities. Forty-one indicators influencing uptake and patient retention along the continuum of HIV care were compared across sites using descriptive statistics. Results: The number of facilities surveyed ranged from six in Malawi to 36 in Zimbabwe. Eighty percent were governmentrun; 73% were lower-level facilities and 17% were district/referral hospitals. Client load varied widely, from less than one up to 65 HIV testing clients per provider per week. Most facilities (>80%) delivered services or interventions that would support patient retention in care such as delivering free services, offering PMTCT within antenatal care, pre-ART monitoring and adherence counselling. Many facilities under-delivered in several areas, however, such as targeted testing for high- risk groups (21%) and mobile testing (36%). There were also intra-site and inter-site differences, including in the delivery of Option B+ (ranging from 6% in Kisumu to 93% in Kyamulibwa), and nurse-led ART initiation (ranging from 50% in Kisesa to 100% in Karonga and Agincourt). Only facilities in Malawi did not require additional lab tests for ART initiation. Stock-outs of HIV test kits and antiretroviral drugs were particularly common in Tanzania. Conclusions: We identified a high standard of health facility performance in delivering strategies that may support progression through the continuum of HIV care. HIV testing policy and practice was particularly weak. Inter- and intracountry differences in quality and coverage represent opportunities to improve the delivery of comprehensive services to people living with HIV. Keywords: HIV; ART; PMTCT; retention; health services; facility surveys; multi-country; continuum

Published
2017

139. Tuberculosis transmission attributable to close contacts and HIV status, Malawi

Author

Crampin, Amelia C., Glynn, Judith R., Traore, Hamidou, Yates, Malcolm D., Mwaungulu, Lorren, Mwenebabu, Michael, Chaguluka, Steven D., Floyd, Sian, Drobniewski, Francis, and Fine, Paul E.M.

Subjects
Disease transmission -- Research, HIV patients -- Research, Tuberculosis -- Research, Tuberculosis -- Prevention
Abstract

We conducted the first molecular study of tuberculosis (TB) to estimate the role of household contact and transmission from HIV-positive putative source contacts (PSCs) in a high HIV-prevalence area. TB [...]

Published
2006

140. Associations between low HDL, sex and cardiovascular risk markers are substantially different in sub-Saharan Africa and the UK: analysis of four population studies

Author

Greiner, Rosamund, primary, Nyirenda, Moffat, additional, Rodgers, Lauren, additional, Asiki, Gershim, additional, Banda, Louis, additional, Shields, Beverley, additional, Hattersley, Andrew, additional, Crampin, Amelia, additional, Newton, Robert, additional, and Jones, Angus, additional

Published
2021
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141. Discovery and fine-mapping of kidney function loci in first genome-wide association study in Africans

Author

Fatumo, Segun, primary, Chikowore, Tinashe, additional, Kalyesubula, Robert, additional, Nsubuga, Rebecca N, additional, Asiki, Gershim, additional, Nashiru, Oyekanmi, additional, Seeley, Janet, additional, Crampin, Amelia C, additional, Nitsch, Dorothea, additional, Smeeth, Liam, additional, Kaleebu, Pontiano, additional, Burgess, Stephen, additional, Nyirenda, Moffat, additional, Franceschini, Nora, additional, Morris, Andrew P, additional, Tomlinson, Laurie, additional, and Newton, Robert, additional

Published
2021
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142. Identification of Reduced Host Transcriptomic Signatures for Tuberculosis Disease and Digital PCR-Based Validation and Quantification

Author

Gliddon, Harriet D., primary, Kaforou, Myrsini, additional, Alikian, Mary, additional, Habgood-Coote, Dominic, additional, Zhou, Chenxi, additional, Oni, Tolu, additional, Anderson, Suzanne T., additional, Brent, Andrew J., additional, Crampin, Amelia C., additional, Eley, Brian, additional, Heyderman, Robert, additional, Kern, Florian, additional, Langford, Paul R., additional, Ottenhoff, Tom H. M., additional, Hibberd, Martin L., additional, French, Neil, additional, Wright, Victoria J., additional, Dockrell, Hazel M., additional, Coin, Lachlan J., additional, Wilkinson, Robert J., additional, and Levin, Michael, additional

Published
2021
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143. Mycobacterium tuberculosis Beijing genotype, northern Malawi

Author

Glynn, Judith R., Crampin, Amelia C., Traore, Hamidou, Yates, Malcolm D., Mwaungulu, Frank D., Ngwira, Bagrey M., Chaguluka, Steven D., Mwafulirwa, Donex T., Floyd, Sian, Murphy, Caroline, Drobniewski, Francis A., and Fine, Paul E.M.

Subjects
Genotype -- Testing, Mycobacterium tuberculosis -- Development and progression, Mycobacterium tuberculosis -- Testing
Abstract

In a 7-year population-based study in Malawi, we showed that Beijing genotype tuberculosis (TB) increased as a proportion of TB cases. All the Beijing genotype strains were fully drug sensitive. [...]

Published
2005

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