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The present article offers a condensed overview, of why a comparative view on gestures in human and nonhuman primates may offer important insights to both: researchers of human as well as of nonhuman primates. It is argued that a comparative view may further contribute to the debate over the evolution of language but that in addition it may also enhance understanding of the relation of language and gesture in humans. The article sketches programmatic issues, which are summarized in the list of framing questions for the workshop and this special issue on “Gestural communication in nonhuman and human primates”; it is aimed to clarify conceptual and methodological prerequisites and to offer points of departure for future comparative research.

Tumor necrosis factor–related apoptosis-inducing ligand (TRAIL) is a highly promising candidate for the treatment of cancer because it elicits cell death in the majority of tumor cells while sparing most normal cells. Some cancers, however, display resistance to TRAIL, suggesting that treatment with TRAIL alone may be insufficient for cancer therapy. In the present study, we explored whether the apoptotic responsiveness of PC-3 prostate cancer cells to TRAIL could be enhanced by targeting the novel protein kinase C (PKC) isoform η. Transfection of PC-3 cells with second-generation chimeric antisense oligonucleotides against PKCη caused a time- and dose-dependent knockdown of PKCη, as revealed by real-time RT-PCR and Western blot analyses. Knockdown of PKCη resulted in a marked amplification of TRAIL's cytotoxic activity. Cell killing could be substantially prevented by the pan-caspase inhibitor z-VAD-fmk. In addition, PKCη knockdown and administration of TRAIL significantly synergized in activation of caspase-3 and internucleosomal DNA fragmentation. Knockdown of PKCη augmented TRAIL-induced dissipation of the mitochondrial transmembrane potential and release of cytochrome c from mitochondria into the cytosol, indicating that PKCη acts upstream of mitochondria. We conclude that PKCη represents a considerable resistance factor with respect to TRAIL and a promising target to exploit the therapeutic potential of TRAIL.

Previous studies point to protein kinase C (PKC) isozyme eta as a resistance factor in cancer cells. Therefore, we investigated whether down-regulation of PKCeta with second generation antisense oligonucleotides (ODNs) would sensitise A549 human lung carcinoma cells to cytostatics. The effects were compared to the outcome of Bcl-xL down-regulation. Upon treatment with antisense ODNs, PKCeta and Bcl-xL were both significantly reduced on mRNA and protein level. Down-regulation of either PKCeta or Bcl-xL in combination with vincristine or paclitaxel resulted in a significant increase in caspase-3 activity compared to that in the control oligonucleotide treated cells. In addition, PKCeta down-regulation augmented vincristine-induced dissipation of mitochondrial transmembrane potential. In conclusion, these results confirm that PKCeta might represent a considerable resistance factor and an interesting target to improve anticancer chemotherapy.

In den Jahren 1999 bis 2001 wurden Ahren und Korner von Weizen, Triticale, Roggen und Gerste auf Infektionen mit Fusarium-Pilzen untersucht. Dabei wurden die Arten Fusarium graminearum und F. avenaceum in Weizen und Triticale im Bereich von 2 bis 7 % nachgewiesen. In wesentlich geringerem Umfang traten F. culmorum, F. poae, M. nivale, F. tricinctum, F. sporotrichoides und F. oxysporum auf.

The IceCube Collaboration has announced the discovery of a neutrino flux in excess of the atmospheric background. Due to the steeply falling atmospheric background spectrum, events at PeV energies are most likely of extraterrestrial origin. We present the multiwavelength properties of the six radio brightest blazars positionally coincident with these events using contemporaneous data of the TANAMI blazar sample, including high-resolution images and spectral energy distributions. Assuming the X-ray to {\gamma}-ray emission originates in the photoproduction of pions by accelerated protons, the integrated predicted neutrino luminosity of these sources is large enough to explain the two detected PeV events., Comment: accepted to A&A, 2 June

[EN] Results are presented on a search for neutrino emission from a sample of six microquasars, based on the data collected by the ANTARES neutrino telescope between 2007 and 2010. By means of appropriate time cuts, the neutrino search has been restricted to the periods when the acceleration of relativistic jets was taking place at the microquasars under study. The time cuts have been chosen using the information from the X-ray telescopes RXTE/ASM and Swift/BAT, and, in one case, the gamma-ray telescope Fermi/LAT. No statistically significant excess has been observed, thus upper limits on the neutrino fluences have been derived and compared to the predictions by models. Constraints have been put on the ratio of proton to electron luminosity in the jets., The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS), Commissariat à l’énergie atomique et aux énergies alternatives (CEA), Agence Nationale de la Recherche (ANR), Commission Européenne (FEDER fund and Marie Curie Program), Région Alsace (contract CPER), Région Provence-Alpes-Côte d’Azur, Département du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium für Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Stichting voor Fundamenteel Onderzoek der Materie (FOM), Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Ciencia e Innovación (MICINN), Prometeo of Generalitat Valenciana and MultiDark, Spain; Agence de l’Oriental and CNRST, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities.

A perlite sample representative of an operating mine in Milos was investigated with respect to the type and spatial distribution of water. A set of different methods was used which finally provided a consistent view on the water at least in this perlite. Infrared spectroscopy showed the presence of different water species (molecular water and hydroxyl groups / strongly bound water). The presence of more than 0.5 mass% smectite, however, could be excluded considering the cation exchange capacity results. The dehydration measured by thermal analysis occurred over a wide range of temperatures hence confirming the infrared spectroscopical results. Both methods point to the existence of a continuous spectrum of water binding energies. The spatial distribution of water and/or pores was investigated using different methods (CT: computer tomography, FIB: scanning electron microscopy including focused ion beam technology, IRM: infrared microscopy). Computer tomography (CT) showed large macropores (20 - 100 μm) and additionally revealed a mottled microstructure of the silicate matrix with low density areas up to a few μm in diameter. Scanning electron microscopy (FIB) confirmed the presence of μm sized pores and IRM showed the filling of these pores with water. In summary, two types of pores were found. Airfilled 20 - 100 μm pores and μm-sized pores disseminated in the glass matrix containing at least some water. Porosity measurements indicate a total porosity of 26 Vol%, 11 Vol% corresponding to the μm-sized pores. It remains unsolved wether the water in the μm-sized pores entered after or throughout perlite formation. However, the pores are sealed and no indications of cracks were found which indicated a primary source of the water, i.e. water was probably entrapped by quenching of the lava. The water in these pores may be the main reason for the thermal expandability which results in the extraordinarily porous expanded perlite building materials. peerReviewed

Context. Blazars are a subset of active galactic nuclei (AGN) with jets that are oriented along our line of sight. Variability and spectral energy distribution (SED) studies are crucial tools for understanding the physical processes responsible for observed AGN emission. Aims. We report peculiar behaviour in the bright gamma-ray blazar PKS 1424-418 and use its strong variability to reveal information about the particle acceleration and interactions in the jet. Methods. Correlation analysis of the extensive optical coverage by the ATOM telescope and nearly continuous gamma-ray coverage by the Fermi Large Area Telescope is combined with broadband, time-dependent modeling of the SED incorporating supplemental information from radio and X-ray observations of this blazar. Results. We analyse in detail four bright phases at optical-GeV energies. These flares of PKS 1424-418 show high correlation between these energy ranges, with the exception of one large optical flare that coincides with relatively low gamma-ray activity. Although the optical/gamma-ray behaviour of PKS 1424-418 shows variety, the multiwavelength modeling indicates that these differences can largely be explained by changes in the flux and energy spectrum of the electrons in the jet that are radiating. We find that for all flares the SED is adequately represented by a leptonic model that includes inverse Compton emission from external radiation fields with similar parameters. Conclusions. Detailed studies of individual blazars like PKS 1424-418 during periods of enhanced activity in different wavebands are helping us identify underlying patterns in the physical parameters in this class of AGN., accepted for publication in A&A

Centaurus A is the closest radio-loud active galaxy. Very Long Baseline Interferometry (VLBI) enables us to study the jet-counterjet system on milliarcsecond (mas) scales, providing essential information for jet emission and propagation models. We study the evolution of the central parsec jet structure of Cen A over 3.5 years. The proper motion analysis of individual jet components allows us to constrain jet formation and propagation and to test the proposed correlation of increased high energy flux with jet ejection events. Cen A is an exceptional laboratory for such detailed study as its proximity translates to unrivaled linear resolution, where 1 mas corresponds to 0.018 pc. The first 7 epochs of high-resolution TANAMI VLBI observations at 8 GHz of Cen A are presented, resolving the jet on (sub-)mas scales. They show a differential motion of the sub-pc scale jet with significantly higher component speeds further downstream where the jet becomes optically thin. We determined apparent component speeds within a range of 0.1c to 0.3c, as well as identified long-term stable features. In combination with the jet-to-counterjet ratio we can constrain the angle to the line of sight to ~12{\deg} to 45{\deg}. The high resolution kinematics are best explained by a spine-sheath structure supported by the downstream acceleration occurring where the jet becomes optically thin. On top of the underlying, continuous flow, TANAMI observations clearly resolve individual jet features. The flow appears to be interrupted by an obstacle causing a local decrease in surface brightness and a circumfluent jet behavior. We propose a jet-star interaction scenario to explain this appearance. The comparison of jet ejection times with high X-ray flux phases yields a partial overlap of the onset of the X-ray emission and increasing jet activity, but the limited data do not support a robust correlation., Comment: 16 pages, 10 figures, A&A, 569, L115 (accepted 23th June, published online 1st October)

Pinning properties of Bi2212 single crystals irradiated with 340 MeV Xe 18+ -ions before and after annealing are investigated and compared. Isothermal magnetic hysteresis loops are recorded and ac susceptibility measurements are also carried out. Inhomogeneities forming during the annealing process show higher critical current density, j c , at fields ≳ the matching field, B φ . A strong effect of collective flux pinning in the high magnetic field regime is proposed.

Wir berichten uber 3 Patienten mit einer erworbenen Grunverfarbung der Kopfbehaarung. Die Anamnese ergab, das alle 3 Patienten regelmasig im privaten Swimmingpool badeten. Die Untersuchung der Haare mittels Atomemissionsspektroskopie wies einen exzessiv hohen Kupfergehalt als Ursache der Grunverfarbung nach. An Hand unserer Beobachtungen mochten wir auf die charakteristische Verknupfung dieser exogenen Haarverfarbung mit der Aufnahme von Kupfer durch Schwimmwasser hauseigener Schwimmbecken hinweisen.

Aims. We search for muon neutrinos in coincidence with GRBs with the ANTARES neutrino detector using data from the end of 2007 to 2011. Methods. Expected neutrino fluxes were calculated for each burst individually. The most recent numerical calculations of the spectra using the NeuCosmA code were employed, which include Monte Carlo simulations of the full underlying photohadronic interaction processes. The discovery probability for a selection of 296 GRBs in the given period was optimised using an extended maximum-likelihood strategy. Results. No significant excess over background is found in the data, and 90% confidence level upper limits are placed on the total expected flux according to the model., The authors acknowledge the financial support of the funding agencies: Centre National de la Recherche Scientifique (CNRS),Commissariat à l’énergie atomique et aux énergies alternatives (CEA), Agence National de la Recherche (ANR), Commission Européenne (FEDER fund and Marie Curie Program), Région Alsace (contrat CPER), Région Provence-Alpes- Côte d’Azur, Département du Var and Ville de La Seyne-sur-Mer, France; Bundesministerium für Bildung und Forschung (BMBF), Germany; Istituto Nazionale di Fisica Nucleare (INFN), Italy; Stichting voor Fundamenteel Onderzoek der Materie (FOM), Nederlandse organisatie voor Wetenschappelijk Onderzoek (NWO), the Netherlands; Council of the President of the Russian Federation for young scientists and leading scientific schools supporting grants, Russia; National Authority for Scientific Research (ANCS), Romania; Ministerio de Ciencia e Innovación (MICINN), Prometeo of Generalitat Valenciana and MultiDark, Spain; Agence de l’Oriental and CNRST, Morocco. We also acknowledge the technical support of Ifremer, AIM and Foselev Marine for the sea operation and the CC-IN2P3 for the computing facilities. We would like to thank Walter Winter for helpful discussions and making it possible to use the NeuCosmA model.

Cadmium concentrations were determined in semen samples of 12 men with proven fertility (group I) and 44 normozoospermic patients (group II) as well as 118 unselected patients of an infertility clinic (group III) and 2 industrial workers with occupational exposure to cadmium. Mean cadmium concentrations in seminal plasma for groups I, II, and III did not show significant differences: 0.38 +/- 0.64; 0.43 +/- 0.69; 0.44 +/- 0.73 (mean +/- SD, micrograms/L), but the two cadmium-exposed patients revealed exceptionally high cadmium levels: 3.46 micrograms/L and 2.99 micrograms/L, respectively. There was no significant correlation between seminal cadmium concentrations and conventional semen parameters or between cadmium concentration and the fertility status of the patients. However, mean cadmium concentrations in seminal plasma of normozoospermic patients were higher in the group of smokers (0.55 +/- 0.81 micrograms/L), compared with the group of nonsmokers (0.42 +/- 0.67 micrograms/L), and there was a weak correlation between cadmium concentration and number of cigarettes consumed per day.

The supremacy of low-pressure valves (LPV) in the therapy of patients with idiopathic normal pressure hydrocephalus (iNPH) has been proven by the Dutch NPH study. The downside of LPVs is the high rate of overdrainage complications. In the meantime gravitational units have been developed with the objective of minimising overdrainage complications. Do these gravitational units allow the same favourable outcomes as in the Dutch NPH study without overdrainage complications? The goal of this prospective randomised controlled multicentre trial is to compare the rate of overdrainage complications after shunt surgery with programmable valves with or without a gravitational unit.Patients suspected with iNPH with gait ataxia and one or two other symptoms of Hakim's triad and enlarged ventricles on CT or MRI underwent a cerebrospinal fluid (CSF) infusion test, CSF tap test and/or continuous ICP measurement in seven experienced centres. If iNPH was diagnosed the patients were randomised to receive a ventriculoperitoneal shunt with a programmable valve with or without a gravitational unit. The patients were followed up for 3, 6 and 12 months after surgery. The primary hypothesis of the study was that programmable valves with gravitational units will reduce the rate of overdrainage from 25% to 10%. The outcome measured by iNPH-specific outcome scales (Kiefer score, Black grading scale) and the generic quality of life (short form 12, SF12) was defined as the secondary endpoint. To detect the hypothesised difference in the incidence of overdrainage with a type I error of 5% and a type II error of 20%, correcting for multiple testing and an anticipated drop-out rate of 10%, we planned to enrol 250 patients. To ensure safety and efficacy we performed a planned interim analysis halfway.The study design has been found to be effective with regard to the primary hypothesis.The design of the SVASONA study was developed to be able to confirm the primary hypothesis. Thus, the method of the study should solve the dilemma of the Dutch NPH study by the randomised comparison of LPVs with and without gravitational units.

ZusammenfassungDas Neugeborenenscreening in Deutschland umfasst zurzeit die Suche nach zwei Endokrinopathien und 12 Stoffwechselerkrankungen. Die beiden häufigsten endokrinen Störungen im Kindesalter, primäre angeborener Hypothyreose und klassisches Adrenogenitales Syndrom, werden durch die Bestimmung von TSH und 17-OH-P detektiert. Weiterhin wird mittels Tandem-Massenspektrometrie nach Erkrankungen im Bereich des Aminosäurenstoffwechsels, der Fettsäurenoxidation und der Organoacidurien gesucht. Die Probennahme erfolgt optimal am 3. Lebenstag, wobei Fersen-oder Venenblut ohne Zusätze auf Filterpapier getropft wird, nach dem Trocknen muss die Probenkarte unverzüglich an das Screeninglabor geschickt werden. Korrekte Präanalytik, umgehender Postversand, schnelle Bearbeitung der Analysen, unverzügliche Konfirmationsdiagnostik und die Behandlung durch Endokrinologen bzw. Stoffwechselspezialisten sind Vorraussetzungen für ein erfolgreiches Neugeborenenscreening.

Im Rahmen von Untersuchungen zum Vorkommen pflanzenpathogener Viren in Oberflachengewassern in der Umgebung von Halle/Saale (Sachsen‐Anhalt) konnten in den Jahren 1986 bis 1992 neben dem tobacco mosaic virus (TMV) und dem tobacco necrosis virus (TNV) wiederholt das grapevine Algerian latent virus (GALV) und das Petunia asteroid mosaic virus (PAMV) gefunden werden. Die letztgenannten Viren waren auch aus dem Boden des unmittelbaren Uferbereiches der Gotsche zu isolieren. Von 36 Arten aus 22 Pflanzenfamilien erwiesen sich Urtica dioica L., Stellaria media (L.) Vill., Rumex crispus L. und Prunus domestica L. als naturliche Wirtspflanzen des GALV. Das PAMV wurde in U. dioica, St. media, Galium aparine L., Plantago major L., Amaranthus retroflexus L. sowie in Taraxacum officinale Wiggers gefunden. Alle genannten Wirtspflanzen zeigten keine sichtbaren Symptome. Beide Viren konnten haufiger in Wurzelproben als in Blattmaterial nachgewiesen werden. Offensichtlich bleiben das GALV und das PAMV bei Infektionen uber...

Delayed cerebral ischemia remains a severe potential complication of aneurysmal subarachnoid hemorrhage (SAH) possibly leading to death and disability. We evaluated a semiquantitative and visual analysis of perfusion computed tomography (PCT) as a predictor of clinically relevant vasospasm (CRV) in patients with aneurysmal SAH. Thirty-eight patients with aneurysmal SAH were analyzed yielding 145 PCT scans. PCT, clinical examination, and transcranial Doppler ultrasound (TCD) were performed on days 3, 7, 10, and 14 after hemorrhage. Cerebral blood flow, cerebral blood volume, and time to peak (TTP) were analyzed semiquantitatively using six regions of interest, and visually for signs of cerebral hypoperfusion. CRV was defined as secondary cerebral infarction (CI) seen on cranial computed tomography scans and/or delayed neurological deterioration (DND). CI occurred in 13 (34.2 %) and DND in 11 patients (28.9 %). With TCD as pretest, TTP had a sensitivity of 90 % and a specificity of 72 % (cutoff value, 0.963) as predictor for CI. TTP’s sensitivity as predictor for DND was 90 % with a specificity of 61.1 % (cutoff value, 0.983). Visual analysis of TTP showed a negative predictive value of 100 % with a positive predictive value of 52 %. TTP is a sensitive and specific perfusion parameter in predicting CI in patients with SAH. Its use in the clinical setting may optimize the early treatment of patients at risk for vasospasm before the onset of clinical deterioration, especially when applying TCD as pretest. Further investigation in a larger patient population is required.

Professional musicians constitute a model par excellence for understanding experience-dependent plasticity in the human brain, particularly in the auditory domain. Their intensive sensorimotor experience with musical instruments has been shown to entail plastic brain alterations in cortical perceptual and motor maps. It remains an important question whether this neuroplasticity might extend beyond basic perceptual and motor functions and even shape higher-level conceptualizations by which we conceive our physical and social world. Here we show using functional magnetic resonance imaging (fMRI) that conceptual processing of visually presented musical instruments activates auditory association cortex encompassing right posterior superior temporal gyrus, as well as adjacent areas in the superior temporal sulcus and the upper part of middle temporal gyrus (pSTG/MTG) only in musicians, but not in musical laypersons. These areas in and adjacent to auditory association cortex were not only recruited by conceptual processing of musical instruments during visual object recognition, but also by auditory perception of real sounds. Hence, the unique intensive experience of musicians with musical instruments establishes a link between auditory perceptual and conceptual brain systems. Experience-driven neuroplasticity in musicians is thus not confined to alterations of perceptual and motor maps, but even leads to the establishment of higher-level semantic representations for musical instruments in and adjacent to auditory association cortex. These findings highlight the eminent importance of sensory and motor experience for acquiring rich concepts.

TANAMI (Tracking Active Galactic Nuclei with Austral Milliarcsecond Interferometry) is a monitoring program to study the parsec-scale structures and dynamics of relativistic jets in active galactic nuclei (AGN) of the Southern Hemisphere with the Long Baseline Array and associated telescopes. Extragalactic jets south of -30 degrees declination are observed at 8.4 GHz and 22 GHz every two months at milliarcsecond resolution. The initial TANAMI sample is a hybrid radio and gamma-ray selected sample since the combination of VLBI and gamma-ray observations is crucial to understand the broadband emission characteristics of AGN., Comment: Confernce Proceedings for "X-ray Astronomy 2009" (Bologna), 3 pages, 3 figures, needs cls-file