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Galvez, Marisa. Songbook: how lyrics became poetry in medieval Europe. Chicago, 2012. 281p bibl index alp ISBN 9780226280516, $35.00 50-0656 PN688 2011-46238 CIP Here is an innovative comparative study that [...]

49-6656 85310 MARC Diagne, Souleymane Bachir. African art as philosophy: Senghor, Bergson and the idea of negritude, tr. by Chike Jeffers. Seagull Books, 2012 (c2011). 210p bibl ISBN 1906497893, $25.00; [...]

49-4903 PA4167 MARC Said, Suzanne. Homer and the Odyssey, tr. by Ruth Webb. Oxford, 2011. 420p bibl index afp ISBN 9780199542840, $110.00; ISBN 9780199542857 pbk, $45.00 Including a robust ten-page [...]

49-4340 PQ156 2011-11228 CIP Cerquiglini-Toulet, Jacqueline. A new history of medieval French literature, tr. by Sara Preisig. Johns Hopkins, 2011. 165p bibl afp ISBN 142140303X, $65.00; ISBN 9781421403038, $65.00 The [...]

49-3116 PN57 2011-11890 CIP Montiglio, Silvia. From villain to hero: Odysseus in ancient thought. Michigan, 2011. 228p bibl indexes afp ISBN 9780472117741, $70.00; ISBN 9780472027507 e-book, contact publisher for price [...]

CFTR,the cystic fibrosis (CF) gene, encodes for the CFTR protein that plays an essential role in anion regulation and tissue homeostasis of various epithelia. In the gastrointestinal (GI) tract CFTR promotes chloride and bicarbonate secretion, playing an essential role in ion and acid–base homeostasis. Cftrhas been identified as a candidate driver gene for colorectal cancer (CRC) in several Sleeping BeautyDNA transposon-based forward genetic screens in mice. Further, recent epidemiological and clinical studies indicate that CF patients are at high risk for developing tumors in the colon. To investigate the effects of CFTR dysregulation on GI cancer, we generated ApcMinmice that carried an intestinal-specific knockout of Cftr. Our results indicate that Cftris a tumor suppressor gene in the intestinal tract as Cftrmutant mice developed significantly more tumors in the colon and the entire small intestine. In Apc+/+mice aged to ~1 year, Cftrdeficiency alone caused the development of intestinal tumors in >60% of mice. Colon organoid formation was significantly increased in organoids created from Cftrmutant mice compared with wild-type controls, suggesting a potential role of Cftrin regulating the intestinal stem cell compartment. Microarray data from the Cftr-deficient colon and the small intestine identified dysregulated genes that belong to groups of immune response, ion channel, intestinal stem cell and other growth signaling regulators. These associated clusters of genes were confirmed by pathway analysis using Ingenuity Pathway Analysis and gene set enrichment analysis (GSEA). We also conducted RNA Seq analysis of tumors from Apc+/+Cftrknockout mice and identified sets of genes dysregulated in tumors including altered Wnt ß-catenin target genes. Finally we analyzed expression of CFTR in early stage human CRC patients stratified by risk of recurrence and found that loss of expression of CFTR was significantly associated with poor disease-free survival.

49-1310 PA6519 2011-7081 CIP Fratantuono, Lee. Madness transformed: a reading of Ovid's Metamorphoses. Lexington Books, 2011. 487p bibl index afp ISBN 9780739129432, $100.00; ISBN 9780739129449 pbk, $46.95 Fratantuono (Ohio Wesleyan [...]

49-0703 PA4252 MARC Shorrock, Robert. The myth of paganism: Nonnus, Dionysius and the world of late antiquity. Duckworth, 2011.181 p bibl index ISBN 0715636685 pbk, $33.00; ISBN 9780715636688 pbk, $33.00 [...]

49-0158 PQ1581 2011-2928 CIP Valentin el Orson: an edition and translation of the fifteenth-century romance epic, ed. and tr. by Shira Schwam-Baird. Arizona Center for Medieval and Renaissance Studies, 2011. [...]

48-5536 PR313 2009-47991 CIP A Companion to medieval poetry, ed. by Corinne Saunders. Wiley-Blackwell, 2010. 683p bibl index afp (Blackwell companions to literature and culture, 67) ISBN 1405159634, $199.95; ISBN [...]

48-2918 BX4668 2010-4925 CIP Schmitt, Jean-Claude. The conversion of Herman the Jew: autobiography, history, and fiction in the twelfth century, tr. by Alex J. Novikoff. Pennsylvania, 2010. 302p bibl index [...]

48-1847 PN171 M A R C Beyond adaptation: essays on radical transformations of original works, ed. by Phyllis Frus and Christy Williams. McFarland, 2010. 216p bibl index alp ISBN 9780786442232 [...]

48-0716 PA4037 2010-894 CIP Sammons, Benjamin. The art and rhetoric of the Homeric catalogue. Oxford, 2010. 233p bibl indexes alp ISBN 9780195375688, $74.00 Catalogues in Homer's Iliad and Odyssey are [...]

47-5477 PN81 2009-464578 Can. CIP Maynard, John. Literary intention, literary interpretation, and readers. Broadview Press, 2009. 448p bibl index afp ISBN 9781551118970 pbk, $34.95 In Intentionality: An Essay in the [...]

47-4861 PA6519 MARC Janan, Micaela. Reflections in a serpent's eye: Thebes in Ovid's Metamorphoses. Oxford, 2010 (c2009). 276p bibl indexes afp ISBN 9780199556922, $90.00 Janan's snappy prose, close readings, and [...]

47-3696 PN1995 MARC Medieval film, ed. by Anke Bernau and Bettina Bildhauer. Manchester University Press, 2009. 241 p index ISBN 9780719077029, $84.95 At once witty, innovative, and intellectually satisfying, this [...]

47-3629 PR2248 2009-16876 CIP Berman, Antoine. Toward a translation criticism: John Donne, ed. and tr. by Francoise Massardier-Kenney. Kent State, 2009. 249p bibl index afp (Translation studies, 6) ISBN 9781606350096 [...]

47-3043 PQ155 2009-8083 CIP Kelly, Molly Robinson. The hero's place: medieval literary traditions of space and belonging. Catholic University of America, 2009. 320p bibl index afp ISBN 9780813216850, $74.95 Noting [...]

47-2458 PR6058 MARC Ted Hughes and the classics, ed. by Roger Rees. Oxford, 2009. 348p bibl index afp ISBN 9780199229710, $135.00 Prolific, subtle, and sensitive, British poet laureate (1984-98) Ted [...]

47-2430 PS161 2008-48351 CIP Halliday, Iain. Huck Finn in Italian, Pinocchio in English: theory and praxis of literary translation. Fairleigh Dickinson, 2009. (Dist. by Associated University Presses) 187p bibl index [...]

47-1850 PA4037 2009-1421 CIP Reading Homer: film and text, ed. by Kostas Myrsiades. Fairleigh Dickinson, 2009. (Dist. by Associated University Presses) 258p bibl index afp ISBN 9780838642191, $39.99 Delightful, amazing, [...]

47-0747 PQ211 2008-44405 CIP Smith, Geri L. The medieval French pastourelle tradition: poetic motivations and generic transformations. University Press of Florida, 2009. 321p bibl index afp ISBN 9780813033365, $75.00 Originally [...]

47-0745 PQ711 2008-49126 CIP Goodman, Dena. Becoming a woman in the age of letters. Cornell, 2009. 386p index alp ISBN 9780801447617, $79.95; ISBN 9780801475450 pbk, $29.95 The French Enlightenment saw [...]

47-0119 PA6519 2008-40710 CIP Pavlock, Barbara. The image of the poet in Ovid's Metamorphoses. Wisconsin, 2009. 198p bibl index afp ISBN 9780299231408, $55.00 An astute and perceptive Latinist, Pavlock (Lehigh [...]

46-3132 PQ1167 2007-32474 CIP French women poets of nine centuries: the distaff & the pen, selected and tr. by Norman R. Shapiro, introd, by Roberta Krueger, Catherine Lafarge, and Catherine [...]