Search

An introduction to the journal is presented in which the editor discusses various reports in the issue on the topics including one on demographic society, the other on digital preservation and the third on challenges in information literacies.

A three-step synthesis of the 2-azabicyclo[3.3.1]nonane ring system from simple pyrroles, employing a combined photochemical/palladium-catalysed approach is reported. Substrate scope is broad, allowing the incorporation of a wide range of functionality relevant to medicinal chemistry. Mechanistic studies demonstrate that the process occurs by acid-assisted C-N bond cleavage followed by β-hydride elimination to form a reactive diene, demonstrating that efficient control of what might be considered off-cycle reactions can result in productive tandem catalytic processes. This represents a short and versatile route to the biologically important morphan scaffold., (© 2020 The Authors. Published by Wiley-VCH GmbH.)

Tetrahydroisoquinolines and tetrahydrobenzazepines were prepared by acid-promoted ring contraction of cyclic ureas, which were themselves formed by ring expansion of indolines and tetrahydroquinolines. The consequent overall one-carbon insertion reaction gives these 6- and 7-membered heterocyclic scaffolds in three steps from readily available precursors. Other ring sizes may be formed by an alternative elimination reaction of bicyclic structures. Scalability of the method was demonstrated by operating it in a flow system., (© 2018 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.)

The introduction of modern matrons--strong clinical leaders--is part of Government policy for the health service. In October 2001 the post of urology matron was set up in one London trust. This paper discusses her experience of the job, examines the key objectives for the matron role and describes the challenges faced.