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103. Abstract 3381: Establishment of a novel multi-omic biomarker panel in cyst fluid and blood for stratifying patient risk of pancreatic cancer

Author

Kane, Laura E., primary, Mellotte, Gregory S., additional, Lyons, Rebecca G., additional, Mylod, Eimear, additional, Marcone, Simone, additional, Ridway, Paul F., additional, MacCarthy, Finbar, additional, Conlon, Kevin C., additional, Lysaght, Joanne, additional, Ryan, Barbara M., additional, and Maher, Stephen G., additional

Published
2022
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104. Abstract CT147: Phase 1 study of recombinant interleukin 15 (rhIL-15) in combination with checkpoint inhibitors nivolumab and ipilimumab in subjects with refractory cancers

Author

Shin, Sarah J., primary, O'Sullivan Coyne, Geraldine, additional, Streicher, Howard, additional, Takebe, Naoko, additional, Bruns, Ashley, additional, Sharon, Elad, additional, Piekarz, Richard, additional, Juwara, Lamin, additional, Rubinstein, Larry, additional, Parchment, Ralph, additional, Fino, Kristin, additional, Fung, King L., additional, Ferry-Galow, Katherine, additional, Mittra, Arjun, additional, Naqash, Abdul Rafeh, additional, Conlon, Kevin, additional, Doroshow, James H., additional, and Chen, Alice P., additional

Published
2022
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106. Integrated phosphoproteomic and metabolomic profiling reveals NPM-ALK–mediated phosphorylation of PKM2 and metabolic reprogramming in anaplastic large cell lymphoma

Author

McDonnell, Scott R.P., Hwang, Steven R., Rolland, Delphine, Murga-Zamalloa, Carlos, Basrur, Venkatesha, Conlon, Kevin P., Fermin, Damian, Wolfe, Thomas, Raskind, Alexander, Ruan, Chunhai, Jiang, Jian-Kang, Thomas, Craig J., Hogaboam, Cory M., Burant, Charles F., Elenitoba-Johnson, Kojo S.J., and Lim, Megan S.

Published
2013
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108. Phase 1 trial of IL-15 trans presentation blockade using humanized Mik-Beta-1 mAb in patients with T-cell large granular lymphocytic leukemia

Author

Waldmann, Thomas A., Conlon, Kevin C., Stewart, Donn M., Worthy, TatYana A., Janik, John E., Fleisher, Thomas A., Albert, Paul S., Figg, William D., Spencer, Shawn D., Raffeld, Mark, Decker, Jean R., Goldman, Carolyn K., Bryant, Bonita R., Petrus, Michael N., Creekmore, Stephen P., and Morris, John C.

Published
2013
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109. International Delphi Expert Consensus on Safe Return to Surgical and Endoscopic Practice

Author

Asbun, Horacio J., Abu Hilal, Mohammad, Kunzler, Filipe, Asbun, Domenech, Bonjer, Jaap, Conlon, Kevin, Demartines, Nicolas, Feldman, Liane S., Morales-Conde, Salvador, Pietrabissa, Andrea, Pryor, Aurora D., Schlachta, Christopher M., Sylla, Patricia, Targarona, Eduardo M., Agra, Yolanda, Besselink, Marc G., Callery, Mark, Cleary, Sean P., De La Cruz, Luis, Eckert, Philippe, Evans, Chad, Han, Ho-Seong, Jones, Daniel B., Gan, Tong Joo, Koch, Daniel, Lillemoe, Keith D., Lomanto, Davide, Marks, Jeffrey, Matthews, Brent, Mellinger, John, Melvin, William Scott, Moreno-Paquentin, Eduardo, Navarrete, Claudio, Pawlik, Timothy M., Pessaux, Patrick, Ricciardi, Walter, Schwaitzberg, Steven, Shah, Paresh, Szokol, Joseph, Talamini, Mark, Torres, Ricardo, Triboldi, Alessandro, Udomsawaengsup, Suthep, Valsecchi, Federica, Vauthey, Jean-Nicolas, Wallace, Michael, Wexner, Steven D., Zinner, Michael, and Francis, Nader

Subjects
Infection Control, Consensus, Internationality, Delphi Technique, pandemic, resumption, pathways, coronavirus, COVID-19, Endoscopy, Delphi, surgery, backlog, Elective Surgical Procedures, recommendations, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, Humans, Triage, resources, Intersectoral Collaboration
Abstract

Supplemental Digital Content is available in the text, Objective: The aim of this work is to formulate recommendations based on global expert consensus to guide the surgical community on the safe resumption of surgical and endoscopic activities. Background: The COVID-19 pandemic has caused marked disruptions in the delivery of surgical care worldwide. A thoughtful, structured approach to resuming surgical services is necessary as the impact of COVID-19 becomes better controlled. The Coronavirus Global Surgical Collaborative sought to formulate, through rigorous scientific methodology, consensus-based recommendations in collaboration with a multidisciplinary group of international experts and policymakers. Methods: Recommendations were developed following a Delphi process. Domain topics were formulated and subsequently subdivided into questions pertinent to different aspects of surgical care in the COVID-19 crisis. Forty-four experts from 15 countries across 4 continents drafted statements based on the specific questions. Anonymous Delphi voting on the statements was performed in 2 rounds, as well as in a telepresence meeting. Results: One hundred statements were formulated across 10 domains. The statements addressed terminology, impact on procedural services, patient/staff safety, managing a backlog of surgeries, methods to restart and sustain surgical services, education, and research. Eighty-three of the statements were approved during the first round of Delphi voting, and 11 during the second round. A final telepresence meeting and discussion yielded acceptance of 5 other statements. Conclusions: The Delphi process resulted in 99 recommendations. These consensus statements provide expert guidance, based on scientific methodology, for the safe resumption of surgical activities during the COVID-19 pandemic.

Published
2020

111. Alteration in Levels of Specific miRNAs and Their Potential Protein Targets between Human Pancreatic Cancer Samples, Adjacent Normal Tissue, and Xenografts Derived from These Tumors.

Author

O'Neill, Fiona, Allen-Coyle, Taylor-Jade, Roche, Sandra, Meiller, Justine, Conlon, Neil T., Swan, Niall, Straubinger, Robert M., Geoghegan, Justin, Straubinger, Ninfa L., Conlon, Kevin, McDermott, Ray, O'Sullivan, Finbarr, Henry, Michael, Meleady, Paula, McVey, Gerard, O'Connor, Robert, Moriarty, Michael, and Clynes, Martin

Subjects
PANCREATIC cancer, MICRORNA, PROTEINS, PANCREATIC tumors, XENOGRAFTS
Abstract

Herein, we describe the global comparison of miRNAs in human pancreatic cancer tumors, adjacent normal tissue, and matched patient-derived xenograft models using microarray screening. RNA was extracted from seven tumor, five adjacent normal, and eight FI PDX tumor samples and analyzed by Affymetrix GeneChip miRNA 4.0 array. A transcriptome analysis console (TAC) was used to generate comparative lists of up- and downregulated miRNAs for the comparisons, tumor vs. normal and F1 PDX vs. tumor. Particular attention was paid to miRNAs that were changed in the same direction in both comparisons. We identified the involvement in pancreatic tumor tissue of several miRNAs, including miR4534, miR3154, and miR4742, not previously highlighted as being involved in this type of cancer. Investigation in the parallel mRNA and protein lists from the same samples allowed the elimination of proteins where altered expression correlated with corresponding mRNA levels and was thus less likely to be miRNA regulated. Using the remaining differential expression protein lists for proteins predicted to be targeted for differentially expressed miRNA on our list, we were able to tentatively ascribe specific protein changes to individual miRNA. Particularly interesting target proteins for miRs 615-3p, 2467-3p, 4742-5p, 509-5p, and 605-3p were identified. Prominent among the protein targets are enzymes involved in aldehyde metabolism and membrane transport and trafficking. These results may help to uncover vulnerabilities that could enable novel approaches to treating pancreatic cancer. [ABSTRACT FROM AUTHOR]

Published
2023
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113. EP1019: THE EFFECTS OF THE COVID-19 PANDEMIC ON PRESENTATIONS AND DIAGNOSIS OF UPPER GI AND HEPATOPANCREATICOBILIARY MALIGNANCIES

Author

Carroll, Andrew, primary, Costigan, Conor, additional, Gavin, Nicholas, additional, Walker, Caroline, additional, Ryan, Barbara M., additional, Breslin, Niall, additional, Mcnamara, Deirdre, additional, O'Donnell, Sarah, additional, Hayden, Una, additional, Ridgway, Paul, additional, Conlon, Kevin, additional, O'Morain, Colm A., additional, and O'Connor, Anthony, additional

Published
2022
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114. Diagnosis and treatment of exocrine pancreatic insufficiency in chronic pancreatitis: An international expert survey and case vignette study

Author

de Rijk, Florence E.M., primary, van Veldhuisen, Charlotte L., additional, Besselink, Marc G., additional, van Hooft, Jeanin E., additional, van Santvoort, Hjalmar C., additional, van Geenen, Erwin J.M., additional, Hegyi, Peter, additional, Löhr, J-Matthias, additional, Dominguez-Munoz, Juan E., additional, de Jonge, Pieter Jan F., additional, Bruno, Marco J., additional, Verdonk, Robert C., additional, Falconi, Massimo, additional, Zou, Wen-Bin, additional, Engjom, Trond, additional, Ooi, Chee Y., additional, Sutton, Robert, additional, Frulloni, Luca, additional, Neoptolemos, John, additional, Wilcox, Charles, additional, Miroslav, Vujasinovic, additional, Trikudanathan, Guru, additional, Liao, Zhuan, additional, Hauge, Truls, additional, Mössner, Joachim, additional, Hoge, Chantal, additional, Fockens, Paul, additional, Mieog, Sven, additional, Capurso, Gabriele, additional, Cui, Yunfeng, additional, de Madaria, Enrique, additional, Distler, Marius, additional, Aghdassi, Ali, additional, Whitcomb, David C., additional, Russell, Kylie, additional, Beyer, Georg, additional, Kunovsky, Lumír, additional, Kwanten, Wilhelmus, additional, Nava, Andrea Kazemi, additional, Conlon, Kevin, additional, Siriwardena, A.K., additional, Paiella, Salvatore, additional, Alconchel, Felipe, additional, Marino, Marco Vito, additional, de Meijer, Vincent E., additional, Domingo, Carlos, additional, Kleeff, Jorg, additional, Lakshmanan, Aarti, additional, Lie Chu, Michael Jen, additional, Bouwense, Stefan, additional, Nashidengo, Pueya Rashid, additional, Konstantinos, Perivoliotis, additional, Muttillo, Edoardo Maria, additional, Umar, Garzali Ibrahim, additional, Castro Santiago, Maria Jesus, additional, Lopez-Lopez, Victor, additional, Torri, Francesco, additional, Schmelzle, Moritz, additional, Ignatavicius, Povilas, additional, Wicherts, Dennis, additional, Gomes, Antonio, additional, Machairas, Nikolaos A., additional, Dorovinis, Panagiotis I., additional, Serrablo, Alejandro, additional, Soreide, Kjetil, additional, Rahbari, Mohammad, additional, Jie Chu, Michael Jen, additional, Ptasnuka, Margarita, additional, Petrulionis, Marius, additional, Noel, Colin Byron, additional, Castro, Ernest, additional, Di Martino, Marcello, additional, Recordare, Alfonso, additional, Stättner, Stefan, additional, Ausania, Fabio, additional, Hartman, Vera, additional, Roeyen, Geert, additional, Egorov, Viacheslav, additional, Vanagas, Tomas, additional, Ebrahim, Mohamed, additional, Arabadzhieva, Elena, additional, Malleo, Giuseppe, additional, Li, Liang, additional, Adams, David, additional, Oracz, Grzegorz, additional, Nageshwar, Reddy D., additional, Waldthaler, Alexander, additional, Masamune, Atsushi, additional, Drewes, Asbjorn Mohr, additional, Amodio, Antonio, additional, Tirkes, Temel, additional, Srivastava, Anshu, additional, Beilman, Gregory J., additional, Berger, Zoltan, additional, Lindkvist, Bjorn, additional, Cavestro, Giulia Martina, additional, Gariepy, Cheryl, additional, Czakó, Laszlo, additional, Di Leo, Milena, additional, Sharma, Vishal, additional, Lakhtakia, Sundeep, additional, Rana, Surinder Singh, additional, Duggan, Sinaed N., additional, Kwon, Chang-Il, additional, Phillips, Anna Evans, additional, Forsmark, Christopher E., additional, Gleeson, Ferga C., additional, Lehman, Glen A., additional, Greenhalf, William, additional, Costamagna, Guido, additional, Halloran, Christopher M., additional, Friess, Helmut, additional, Rasmussen, Henrik Hojgaard, additional, Ikeura, Tsukasa, additional, Haldorsen, Ingfrid S., additional, Itoi, Takao, additional, Izbicki, Jacob R., additional, Windsor, John, additional, Poulsen, Jakob Lykke, additional, Frokjaer, Jens Brondum, additional, Larino-Noia, Jose, additional, Wang, Dan, additional, Garcia, Julio Iglesias, additional, Kalaitzakis, Evangelos, additional, Wertheim-Tysarowska, Kararzyna, additional, Kubota, Kensuke, additional, Larusch, Jessica, additional, Lerch, Markus M., additional, Hu, Liang-Hao, additional, Erkan, Mert, additional, Machicado, Jorg D., additional, Arvanitakis, Marianna, additional, Buchler, Markus W., additional, Levy, Marlon F., additional, Heyman, Melvin B., additional, Nojgaard, Camilla, additional, Khashab, Mouen A., additional, Delhaye, Myriam, additional, Ogura, Takeshi, additional, Okazaki, Kazuichi, additional, Ghaneh, Paula, additional, Banks, Peter A., additional, Gupta, Pankaj, additional, Papachristou, Georgios I., additional, Michl, Patrick, additional, Levy, Philippe, additional, Pukitis, Aldis, additional, Pezzilli, Raffaele, additional, Baron, Ryan D., additional, Amann, Stephen T., additional, Schwarzenberg, Sarah Jane, additional, Isaji, Shuiji, additional, Olesen, Soren Schou, additional, Novovic, Srdan, additional, Hughes, Steven J., additional, Werlin, Steven L., additional, Gonska, Tanja, additional, Gardner, Timothy B., additional, Topazian, Mark D., additional, Weiss, Frank Ulrich, additional, Akshintala, Venakata S., additional, Morinville, Veronique D., additional, Rebours, Vinciane, additional, Vincze, Aron, additional, Singh, Vikesh K., additional, Cui, Naiqiang, additional, Zhang, Hong, additional, and Li, Zhao-shen, additional

Published
2022
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116. Additional file 1 of Near infrared indocyanine green fluorescent cholangiography versus intraoperative cholangiography to improve safety in laparoscopic cholecystectomy for gallstone disease���a systematic review protocol

Author

Pavel, Mihai-Calin, Boira, Mar Achalandabaso, Bashir, Yasir, Memba, Robert, Ll��cer, Erik, Estalella, Laia, Juli��, Elisabeth, Conlon, Kevin C., and Jorba, Rosa

Abstract

Additional file 1. PRISMA-P checklist.

Published
2022
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117. Additional file 2 of Near infrared indocyanine green fluorescent cholangiography versus intraoperative cholangiography to improve safety in laparoscopic cholecystectomy for gallstone disease���a systematic review protocol

Author

Pavel, Mihai-Calin, Boira, Mar Achalandabaso, Bashir, Yasir, Memba, Robert, Ll��cer, Erik, Estalella, Laia, Juli��, Elisabeth, Conlon, Kevin C., and Jorba, Rosa

Abstract

Additional file 2. Search strategy for electronic databases (May 7th 2020).

Published
2022
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118. structure of nanomolecular memory , it is possible to substantially reduce the.pdf

Author

Rashid, Afshin, Conlon, Kevin, and Kamel, Basil

Abstract

By using the structure of nanomolecular memory , the size of memory bits can be substantially reduced, thereby increasing the density and efficiency of magnetic memory and lowering the cost and cost. Nanotechnology methods are now being used to provide some very powerful memories. Nanocrystals, the use of which willincrease the lifespan of flash memory. And the development of amagnetic material based on the protein ferritin, which will be usedto make disk drives and memory chips. The production andmanufacture of memory is one of the largest industrial sectors,but it also faces several technical problems; Problems such asleakage from the capacitor, structures with increasing complexity,and sensitivity to minor errors due to cosmic rays. The existenceof such problems makes it impossible for chip makers to reduce their chip dimensions beyond this. Nanoelectronics Science andTechnology Features of Nano Molecular Memory Offerdifferent. Photofraction materials, for example, represent only onetype of optical memory. In fact, using nanotechnology can

Published
2022
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120. Summaries

Author

Wills, Lester, Carney, David, Priestly, Alf, Browne, Tim, Bulling, Jim, Walker, Wayne, Skilton, David, Byrne, Tracy, Hallinan, Michael, Conlon, Kevin, Pepper, Tim, Scott, Jeffrey, and de Fries, Jon

Published
2008

127. Postpancreatectomy Acute Pancreatitis (PPAP)

Author

Marchegiani, Giovanni, Barreto, Savio George, Bannone, Elisa, Sarr, Michael, Vollmer, Charles M, Connor, Saxon, Falconi, Massimo, Besselink, Marc G, Salvia, Roberto, Wolfgang, Christopher L, Zyromski, Nicholas J, Yeo, Charles J, Adham, Mustapha, Siriwardena, Ajith K, Takaori, Kyoichi, Hilal, Mohammad Abu, Loos, Martin, Probst, Pascal, Hackert, Thilo, Strobel, Oliver, Busch, Olivier RC, Lillemoe, Keith D, Miao, Yi, Halloran, Christopher M, Werner, Jens, Friess, Helmut, Izbicki, Jakob R, Bockhorn, Maximillian, Vashist, Yogesh K, Conlon, Kevin, Passas, Ioannis, Gianotti, Luca, Del Chiaro, Marco, Schulick, Richard D, Montorsi, Marco, Oláh, Attila, Fusai, Giuseppe Kito, Serrablo, Alejandro, Zerbi, Alessandro, Fingerhut, Abe, Andersson, Roland, Padbury, Robert, Dervenis, Christos, Neoptolemos, John P, Bassi, Claudio, Büchler, Markus W, and Shrikhande, Shailesh V

Published
2021

129. Surgical and Oncological Outcomes After Preoperative FOLFIRINOX Chemotherapy in Resected Pancreatic Cancer: An International Multicenter Cohort Study

Author

van Veldhuisen, Eran, Klompmaker, Sjors, Janssen, Quisette P., Hilal, Mohammed Abu, Alseidi, Adnan, Balduzzi, Alberto, Balzano, Gianpaolo, Bassi, Claudio, Berrevoet, Frederik, Bonds, Morgan, Busch, Olivier R., Butturini, Giovanni, Conlon, Kevin C., Frigerio, Isabella M., Fusai, Giuseppe K., Gagnière, Johan, Griffin, Oonagh, Hackert, Thilo, Halimi, Asif, Keck, Tobias, Kleeff, Jörg, Klaiber, Ulla, Labori, Knut J., Lesurtel, Mickael, Malleo, Giuseppe, Marino, Marco V., Molenaar, I. Quintus, Mortensen, Michael B., Nikov, Andrej, Pagnanelli, Michele, Pandé, Rupaly, Pfeiffer, Per, Pietrasz, Daniel, Rangelova, Elena, Roberts, Keith J., Cunha, Antonio Sa, Salvia, Roberto, Strobel, Oliver, Tarvainen, Timo, Wilmink, Johanna W., Koerkamp, Bas Groot, Besselink, Marc G., Sauvanet, Alain, Marthey, Lysiane, Laurent, Christophe, Régenet, Nicolas, Coriat, Romain, Taieb, Julien, Turini, Olivier, Graduate School, Surgery, CCA - Cancer Treatment and Quality of Life, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism, Oncology, CCA - Cancer biology and immunology, CCA - Imaging and biomarkers, Internal medicine, University of Helsinki, Clinicum, HUS Abdominal Center, and II kirurgian klinikka

Subjects
Complications, LAPC, Folfrinox, OS, Folfrinox, BRPC, LAPC, OS, Definition, Classification, 3126 Surgery, anesthesiology, intensive care, radiology, Gemcitabine, SDG 3 - Good Health and Well-being, Oncology, Medicine and Health Sciences, Surgery, BRPC
Abstract

Background Preoperative FOLFIRINOX chemotherapy is increasingly administered to patients with borderline resectable (BRPC) and locally advanced pancreatic cancer (LAPC) to improve overall survival (OS). Multicenter studies reporting on the impact from the number of preoperative cycles and the use of adjuvant chemotherapy in relation to outcomes in this setting are lacking. This study aimed to assess the outcome of pancreatectomy after preoperative FOLFIRINOX, including predictors of OS. Methods This international multicenter retrospective cohort study included patients from 31 centers in 19 European countries and the United States undergoing pancreatectomy after preoperative FOLFIRINOX chemotherapy (2012–2016). The primary end point was OS from diagnosis. Survival was assessed using Kaplan-Meier analysis and Cox regression. Results The study included 423 patients who underwent pancreatectomy after a median of six (IQR 5–8) preoperative cycles of FOLFIRINOX. Postoperative major morbidity occurred for 88 (20.8%) patients and 90-day mortality for 12 (2.8%) patients. An R0 resection was achieved for 243 (57.4%) patients, and 259 (61.2%) patients received adjuvant chemotherapy. The median OS was 38 months (95% confidence interval [CI] 34–42 months) for BRPC and 33 months (95% CI 27–45 months) for LAPC. Overall survival was significantly associated with R0 resection (hazard ratio [HR] 1.63; 95% CI 1.20–2.20) and tumor differentiation (HR 1.43; 95% CI 1.08–1.91). Neither the number of preoperative chemotherapy cycles nor the use adjuvant chemotherapy was associated with OS. Conclusions This international multicenter study found that pancreatectomy after FOLFIRINOX chemotherapy is associated with favorable outcomes for patients with BRPC and those with LAPC. Future studies should confirm that the number of neoadjuvant cycles and the use adjuvant chemotherapy have no relation to OS after resection.

Published
2021

130. Pre-operative radiomics model for prognostication in resectable pancreatic adenocarcinoma with external validation

Author

Healy, Gerard M., primary, Salinas-Miranda, Emmanuel, additional, Jain, Rahi, additional, Dong, Xin, additional, Deniffel, Dominik, additional, Borgida, Ayelet, additional, Hosni, Ali, additional, Ryan, David T., additional, Njeze, Nwabundo, additional, McGuire, Anne, additional, Conlon, Kevin C., additional, Dodd, Jonathan D., additional, Ryan, Edmund Ronan, additional, Grant, Robert C., additional, Gallinger, Steven, additional, and Haider, Masoom A., additional

Published
2021
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131. A Novel FBXO45-Gef-H1 Axis Controls Oncogenic Signaling in B-Cell Lymphoma

Author

Sahasrabuddhe, Anagh Anant, primary, Chen, Xiaofei, additional, Ma, Kaiyu, additional, Wu, Rui, additional, Kapoor, Richa, additional, Chhipa, Rishi Raj, additional, Zhang, Xiao, additional, Onder, Ozlem, additional, Wilmore, Joel, additional, Gaudette, Brian T., additional, Pillai, Vinodh, additional, Li, Marilyn M., additional, Ahn, Joon-Young, additional, Chung, Fuzon, additional, Szankasi, Philippe, additional, Basrur, Venkatesha, additional, Conlon, Kevin P, additional, Bailey, Nathanael G., additional, Hogaboam, Cory M, additional, Rottapel, Robert, additional, Kim, Junhyong, additional, Lopez, Cristina, additional, Seufert, Julian, additional, Schlesner, Matthias, additional, Siebert, Reiner, additional, Cancro, Michael P, additional, Allman, David, additional, Pagano, Michele, additional, Staudt, Louis M., additional, Lim, Megan S., additional, and Elenitoba-Johnson, Kojo S. J., additional

Published
2021
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132. Phase I study of single agent NIZ985, a recombinant heterodimeric IL-15 agonist, in adult patients with metastatic or unresectable solid tumors

Author

Conlon, Kevin, primary, Watson, Dionysios C, additional, Waldmann, Thomas A, additional, Valentin, Antonio, additional, Bergamaschi, Cristina, additional, Felber, Barbara K, additional, Peer, Cody J, additional, Figg, William D, additional, Potter, E Lake, additional, Roederer, Mario, additional, McNeel, Douglas G, additional, Thompson, John A, additional, Gupta, Sumati, additional, Leidner, Rom, additional, Wang-Gillam, Andrea, additional, Parikh, Nehal S, additional, Long, Debby, additional, Kurtulus, Sema, additional, Ho Lee, Lang, additional, Chowdhury, Niladri Roy, additional, Bender, Florent, additional, and Pavlakis, George N, additional

Published
2021
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137. The Impact of Neoadjuvant Treatment on Survival in Patients Undergoing Pancreatoduodenectomy With Concomitant Portomesenteric Venous Resection: An International Multicenter Analysis

Author

Machairas, Nikolaos, primary, Raptis, Dimitri A, additional, Velázquez, Patricia Sánchez, additional, Sauvanet, Alain, additional, Rueda de Leon, Alexandra, additional, Oba, Atsushi, additional, Koerkamp, Bas Groot, additional, Lovasik, Brendan, additional, Chan, Carlos, additional, Yeo, Charles J., additional, Bassi, Claudio, additional, Ferrone, Cristina R., additional, Kooby, David, additional, Moskal, David, additional, Tamburrino, Domenico, additional, Yoon, Dong-Sup, additional, Barroso, Eduardo, additional, de Santibañes, Eduardo, additional, Kauffmann, Emanuele F., additional, Vigia, Emanuel, additional, Robin, Fabien, additional, Casciani, Fabio, additional, Burdío, Fernando, additional, Belfiori, Giulio, additional, Malleo, Giuseppe, additional, Lavu, Harish, additional, Hartog, Hermien, additional, Hwang, Ho-Kyoung, additional, Han, Ho-Seong, additional, Marques, Hugo P., additional, Poves, Ignasi, additional, Domínguez-Rosado, Ismael, additional, Park, Joon-Seong, additional, Lillemoe, Keith D., additional, Roberts, Keith, additional, Sulpice, Laurent, additional, Besselink, Marc G., additional, Abuawwad, Mahmoud, additional, Del Chiaro, Marco, additional, de Santibañes, Martin, additional, Falconi, Massimo, additional, D'Silva, Mizelle, additional, Silva, Michael, additional, Hilal, Mohammed Abu, additional, Qadan, Motaz, additional, Sell, Naomi M., additional, Beghdadi, Nassiba, additional, Napoli, Niccolò, additional, Busch, Olivier R. C., additional, Mazza, Oscar, additional, Muiesan, Paolo, additional, Müller, Philip C., additional, Ravikumar, Reena, additional, Schulick, Richard, additional, Powell-Brett, Sarah, additional, Abbas, Syed Hussain, additional, Mackay, Tara M., additional, Stoop, Thomas F., additional, Gallagher, Tom K., additional, Boggi, Ugo, additional, van Eijck, Casper, additional, Clavien, Pierre-Alain, additional, Conlon, Kevin C. P., additional, and Fusai, Giuseppe Kito, additional

Published
2021
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138. Seroprevalence study of SARS-CoV-2 antibodies in healthcare workers following the first wave of the COVID-19 pandemic in a tertiary-level hospital in the south of Ireland

Author

Faller, Eamonn, primary, Wyse, Adrianne, additional, Barry, Rachel, additional, Conlon, Kevin, additional, Everard, Cormac, additional, Finnegan, Paula, additional, Foran, Claire, additional, Herlihy, Emer, additional, Kerr, Gerry, additional, Lapthorne, Susan, additional, McGreal-Bellone, Aimee, additional, Morrissey, Edmond, additional, O’Sullivan, Deirdre, additional, O’Sullivan, Grainne, additional, Eustace, Joseph A, additional, Spillane, Declan, additional, Dempsey, Catherine, additional, Benson, John, additional, Prentice, Mike, additional, Gallagher, John, additional, MacSharry, John, additional, Fanning, Liam J, additional, O’Riordan, Stephen, additional, Horgan, Mary, additional, and Sadlier, Corinna, additional

Published
2021
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139. International Delphi Expert Consensus on Safe Return to Surgical and Endoscopic Practice From the Coronavirus Global Surgical Collaborative

Author

Asbun, Horacio J., Abu Hilal, Mohammad, Kunzler, Filipe, Asbun, Domenech, Bonjer, Jaap, Conlon, Kevin, Morales Conde, Salvador, Francis, Nader, and Universidad de Sevilla. Departamento de Cirugía

Subjects
Endoscopic, Surgical, COVID-19, Delphi
Abstract

Objective: The aim of this work is to formulate recommendations based on global expert consensus to guide the surgical community on the safe resumption of surgical and endoscopic activities. Background: The COVID-19 pandemic has caused marked disruptions in the delivery of surgical care worldwide. A thoughtful, structured approach to resuming surgical services is necessary as the impact of COVID-19 becomes better controlled. The Coronavirus Global Surgical Collaborative sought to formulate, through rigorous scientific methodology, consensus-based recommendations in collaboration with a multidisciplinary group of international experts and policymakers. Methods: Recommendations were developed following a Delphi process. Domain topics were formulated and subsequently subdivided into questions pertinent to different aspects of surgical care in the COVID-19 crisis. Forty-four experts from 15 countries across 4 continents drafted statements based on the specific questions. Anonymous Delphi voting on the statements was performed in 2 rounds, as well as in a telepresence meeting. Results: One hundred statements were formulated across 10 domains. The statements addressed terminology, impact on procedural services, patient/staff safety, managing a backlog of surgeries, methods to restart and sustain surgical services, education, and research. Eighty-three of the statements were approved during the first round of Delphi voting, and 11 during the second round. A final telepresence meeting and discussion yielded acceptance of 5 other statements. Conclusions: The Delphi process resulted in 99 recommendations. These consensus statements provide expert guidance, based on scientific methodology, for the safe resumption of surgical activities during the COVID-19 pandemic.

Published
2021

140. International Delphi Expert Consensus on Safe Return to Surgical and Endoscopic Practice From the Coronavirus Global Surgical Collaborative

Author

Universidad de Sevilla. Departamento de Cirugía, Asbun, Horacio J., Abu Hilal, Mohammad, Kunzler, Filipe, Asbun, Domenech, Bonjer, Jaap, Conlon, Kevin, Morales Conde, Salvador, Francis, Nader, Universidad de Sevilla. Departamento de Cirugía, Asbun, Horacio J., Abu Hilal, Mohammad, Kunzler, Filipe, Asbun, Domenech, Bonjer, Jaap, Conlon, Kevin, Morales Conde, Salvador, and Francis, Nader

Abstract

Objective: The aim of this work is to formulate recommendations based on global expert consensus to guide the surgical community on the safe resumption of surgical and endoscopic activities. Background: The COVID-19 pandemic has caused marked disruptions in the delivery of surgical care worldwide. A thoughtful, structured approach to resuming surgical services is necessary as the impact of COVID-19 becomes better controlled. The Coronavirus Global Surgical Collaborative sought to formulate, through rigorous scientific methodology, consensus-based recommendations in collaboration with a multidisciplinary group of international experts and policymakers. Methods: Recommendations were developed following a Delphi process. Domain topics were formulated and subsequently subdivided into questions pertinent to different aspects of surgical care in the COVID-19 crisis. Forty-four experts from 15 countries across 4 continents drafted statements based on the specific questions. Anonymous Delphi voting on the statements was performed in 2 rounds, as well as in a telepresence meeting. Results: One hundred statements were formulated across 10 domains. The statements addressed terminology, impact on procedural services, patient/staff safety, managing a backlog of surgeries, methods to restart and sustain surgical services, education, and research. Eighty-three of the statements were approved during the first round of Delphi voting, and 11 during the second round. A final telepresence meeting and discussion yielded acceptance of 5 other statements. Conclusions: The Delphi process resulted in 99 recommendations. These consensus statements provide expert guidance, based on scientific methodology, for the safe resumption of surgical activities during the COVID-19 pandemic.

Published
2021

143. Characterization of the transcriptional regulator Rv3124 of Mycobacterium tuberculosis identifies it as a positive regulator of molybdopterin biosynthesis and defines the functional consequences of a non-synonymous SNP in the Mycobacterium bovis BCG orthologue

Author

Lopez, Pablo Mendoza, Golby, Paul, Wooff, Esen, Garcia, Javier Nunez, Pelayo, M. Carmen Garcia, Conlon, Kevin, Camacho, Ana Gema, Hewinson, R. Glyn, Polaina, Julio, Garcia, Antonio Suarez, and Gordon, Stephen V.

Subjects
Genetic regulation -- Research, Mycobacterium bovis -- Health aspects, Mycobacterium bovis -- Genetic aspects, Mycobacterium bovis -- Research, Protein-protein interactions -- Genetic aspects, Protein-protein interactions -- Research, Single nucleotide polymorphisms -- Research, Biological sciences
Abstract

A number of single-nucleotide polymorphisms (SNPs) have been identified in the genome of Mycobacterium bovis BCG Pasteur compared with the sequenced strain M. boris 2122/97. The functional consequences of many of these mutations remain to be described; however, mutations in genes encoding regulators may be particularly relevant to global phenotypic changes such as loss of virulence, since alteration of a regulator's function will affect the expression of a wide range of genes. One such SNP falls in bcg3145, encoding a member of the AfsR/Dnrl/SARP class of global transcriptional regulators, that replaces a highly conserved glutamic acid residue at position 159 (E159G) with glycine in a tetratricopeptide repeat (TPR) located in the bacterial transcriptional activation (BTA) domain of BCG3145. TPR domains are associated with protein--protein interactions, and a conserved core (helices T1-T7) of the BTA domain seems to be required for proper function of SARP-family proteins. Structural modelling predicted that the E159G mutation perturbs the third [alpha]-helix of the BTA domain and could therefore have functional consequences. The E159G SNP was found to be present in all BCG strains, but absent from virulent M. bovis and Mycobacterium tuberculosis strains. By overexpressing BCG3145 and Rv3124 in BCG and H37Rv and monitoring transcriptome changes using microarrays, we determined that BCG3145/Rv3124 acts as a positive transcriptional regulator of the molybdopterin biosynthesis moa1 locus, and we suggest that rv3124 be renamed moaR1. The SNP in bcg3145 was found to have a subtle effect on the activity of MoaR1, suggesting that this mutation is not a key event in the attenuation of BCG. DOI: 10.1099/mic.0.037200-0

Published
2010

145. Definition of a standard lymphadenectomy in surgery for pancreatic ductal adenocarcinoma: A consensus statement by the International Study Group on Pancreatic Surgery (ISGPS)

Author

Tol, Johanna A.M.G., Gouma, Dirk J., Bassi, Claudio, Dervenis, Christos, Montorsi, Marco, Adham, Mustapha, Andrén-Sandberg, Ake, Asbun, Horacio J., Bockhorn, Maximilian, Büchler, Markus W., Conlon, Kevin C., Fernández-Cruz, Laureano, Fingerhut, Abe, Friess, Helmut, Hartwig, Werner, Izbicki, Jakob R., Lillemoe, Keith D., Milicevic, Miroslav N., Neoptolemos, John P., Shrikhande, Shailesh V., Vollmer, Charles M., Yeo, Charles J., and Charnley, Richard M.

Published
2014
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146. Extended pancreatectomy in pancreatic ductal adenocarcinoma: Definition and consensus of the International Study Group for Pancreatic Surgery (ISGPS)

Author

Hartwig, Werner, Vollmer, Charles M., Fingerhut, Abe, Yeo, Charles J., Neoptolemos, John P., Adham, Mustapha, Andrén-Sandberg, Åke, Asbun, Horacio J., Bassi, Claudio, Bockhorn, Max, Charnley, Richard, Conlon, Kevin C., Dervenis, Christos, Fernandez-Cruz, Laureano, Friess, Helmut, Gouma, Dirk J., Imrie, Clem W., Lillemoe, Keith D., Milićević, Miroslav N., Montorsi, Marco, Shrikhande, Shailesh V., Vashist, Yogesh K., Izbicki, Jakob R., and Büchler, Markus W.

Published
2014
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148. Borderline resectable pancreatic cancer: A consensus statement by the International Study Group of Pancreatic Surgery (ISGPS)

Author

Bockhorn, Maximilian, Uzunoglu, Faik G., Adham, Mustapha, Imrie, Clem, Milicevic, Miroslav, Sandberg, Aken A., Asbun, Horacio J., Bassi, Claudio, Büchler, Markus, Charnley, Richard M., Conlon, Kevin, Cruz, Laureano Fernandez, Dervenis, Christos, Fingerhutt, Abe, Friess, Helmut, Gouma, Dirk J., Hartwig, Werner, Lillemoe, Keith D., Montorsi, Marco, Neoptolemos, John P., Shrikhande, Shailesh V., Takaori, Kyoichi, Traverso, William, Vashist, Yogesh K., Vollmer, Charles, Yeo, Charles J., and Izbicki, Jakob R.

Published
2014
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149. When to perform a pancreatoduodenectomy in the absence of positive histology? A consensus statement by the International Study Group of Pancreatic Surgery

Author

Asbun, Horacio J., Conlon, Kevin, Fernandez-Cruz, Laureano, Friess, Helmut, Shrikhande, Shailesh V., Adham, Mustapha, Bassi, Claudio, Bockhorn, Maximilian, Büchler, Markus, Charnley, Richard M., Dervenis, Christos, Fingerhutt, Abe, Gouma, Dirk J., Hartwig, Werner, Imrie, Clem, Izbicki, Jakob R., Lillemoe, Keith D., Milicevic, Miroslav, Montorsi, Marco, Neoptolemos, John P., Sandberg, Aken A., Sarr, Michael, Vollmer, Charles, Yeo, Charles J., and Traverso, William L.

Published
2014
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