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433 results on '"Conklin, Heather M."'

102. Treatment burden and long‐term health deficits of patients with low‐grade gliomas or glioneuronal tumors diagnosed during the first year of life

Author

Liu, Anthony P. Y., primary, Hastings, Camden, additional, Wu, Shengjie, additional, Bass, Johnnie K., additional, Heitzer, Andrew M., additional, Ashford, Jason, additional, Vestal, Robert, additional, Hoehn, Mary E., additional, Ghazwani, Yahya, additional, Acharya, Sahaja, additional, Conklin, Heather M., additional, Boop, Frederick, additional, Merchant, Thomas E., additional, Gajjar, Amar, additional, and Qaddoumi, Ibrahim, additional

Published
2019
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105. Computerized assessment of cognitive impairment among children undergoing radiation therapy for medulloblastoma

Author

Heitzer, Andrew M., primary, Ashford, Jason M., additional, Harel, Brian T., additional, Schembri, Adrian, additional, Swain, Michelle A., additional, Wallace, Joanna, additional, Ness, Kirsten K., additional, Wang, Fang, additional, Zhang, Hui, additional, Merchant, Thomas E., additional, Robinson, Giles W., additional, Gajjar, Amar, additional, and Conklin, Heather M., additional

Published
2018
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106. Neuropsychological outcomes of patients with low-grade glioma diagnosed during the first year of life

Author

Heitzer, Andrew M., primary, Ashford, Jason M., additional, Hastings, Camden, additional, Liu, Anthony P. Y., additional, Wu, Shengjie, additional, Bass, Johnnie K., additional, Vestal, Robert, additional, Hoehn, Mary, additional, Chiang, Jason, additional, Ghazwani, Yahya, additional, Acharya, Sahaja, additional, Boop, Frederick, additional, Gajjar, Amar, additional, Merchant, Thomas E., additional, Qaddoumi, Ibrahim, additional, and Conklin, Heather M., additional

Published
2018
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108. Longitudinal Trajectories of Neurocognitive Functioning in Childhood Acute Lymphoblastic Leukemia.

Author

Partanen, Marita, Phipps, Sean, Russell, Kathryn, Anghelescu, Doralina L, Wolf, Joshua, Conklin, Heather M, Krull, Kevin R, Inaba, Hiroto, Pui, Ching-Hon, and Jacola, Lisa M

Subjects
LYMPHOBLASTIC leukemia, CONTINUOUS performance test, ACUTE leukemia, VERBAL learning
Abstract

Objective: Children with acute lymphoblastic leukemia (ALL) are at risk for neurocognitive deficits, and examining individual variability is essential to understand these risks. This study evaluated latent longitudinal trajectories and risk factors of neurocognitive outcomes in childhood ALL.Methods: There were 233 participants with ALL who were enrolled on a phase 3, risk-stratified chemotherapy-only clinical trial (NCT00137111) and who completed protocol-directed neurocognitive assessments [47.6% female, mean (SD) = 6.6 (3.7) years]. Measures of sustained attention, learning/memory, and parent ratings of attention were completed during and after treatment. Longitudinal latent class analyses were used to classify participants into distinct trajectories. Logistic regression was used to identify predictors of class membership.Results: Within the overall group, attention performance was below age expectations across time (Conners Continuous Performance Test detectability/variability, p < 0.01); memory performance and parent ratings were below expectations at later phases (California Verbal Learning Test learning slope, p < 0.05; Conners Parent Rating Scale, Revised attention/learning, p < 0.05). Most participants (80-89%) had stable neurocognitive profiles; smaller groups showed declining (3-6%) or improving (3-11%) trajectories. Older age (p = 0.020), female sex (p = 0.018), and experiencing sepsis (p = 0.047) were associated with greater attention problems over time. Lower baseline IQ was associated with improved memory (p = 0.035) and fewer ratings of attention problems (p = 0.013) over time.Conclusions: Most patients with ALL have stable neurocognitive profiles. Smaller groups have significant impairments shortly after diagnosis or have worsening performance over time. A tiered assessment approach, which includes consideration of individual and clinical risk factors, may be useful for monitoring neurocognitive functioning during treatment and survivorship. [ABSTRACT FROM AUTHOR]

Published
2021
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111. Neurocognitive Outcomes among Children who Experienced Seizures during Treatment for Acute Lymphoblastic Leukemia

Author

Nassar, Stephanie L., Conklin, Heather M., Zhou, Yinmei, Ashford, Jason M., Reddick, Wilburn E., Glass, John O., Laningham, Fred H., Jeha, Sima, Cheng, Cheng, and Pui, Ching-Hon

Subjects
Male, Adolescent, Hydrocortisone, Mercaptopurine, Incidence, Cytarabine, Neuropsychological Tests, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Magnetic Resonance Imaging, Article, Dexamethasone, Methotrexate, Leukoencephalopathies, Risk Factors, Seizures, Vincristine, Child, Preschool, Antineoplastic Combined Chemotherapy Protocols, Humans, Female, Child, Cognition Disorders
Abstract

Limited information is available regarding neurocognitive outcomes of children who experience seizures during treatment for acute lymphoblastic leukemia (ALL). Accordingly, the main objectives of this study were to determine the incidence and risk factors for treatment-related seizures among children with ALL, and the neurocognitive outcomes associated with treatment-related seizures.Prospective neuropsychological assessment and magnetic resonance imaging (MRI) were planned for all 498 patients with newly diagnosed ALL enrolled on the St. Jude Total Therapy XV (TOTXV) protocol at three time points. The study database was reviewed retrospectively to identify those with treatment-related seizure. To assess neurocognitive changes associated with seizure, each patient with treatment-related seizure was matched with two cohort patients without seizure for age at treatment, gender, race, and treatment intensity.Nineteen patients developed seizure, with a 2-year cumulative risk of 3.82 ± 0.86% (SE). No risk factors were identified to be associated with the development of seizure, with a possible exception of intensive chemotherapy used on the standard/high-risk arm as compared to the low-risk arm. Neuropsychological performance of the seizure group, as compared to normative scores and nonseizure control cohort, indicated problems in attention, working memory, and processing speed. Cognitive deficits persisted 2 years after therapy, with additional declines in intellectual function observed. MRI indicated early neurotoxicity among the seizure group, as evidenced by greater leukoencephalopathy on initial examinations.Treatment-related seizures were associated with leukoencephalopathy and decreased neuropsychological performance. Prospective studies are needed to detect changes in neurocognitive status associated with long-term functional impairment.

Published
2017

118. Reply to S. Kaur et al

Author

Jacola, Lisa M., primary, Krull, Kevin R., additional, Pui, Ching-Hon, additional, Pei, Deqing, additional, Cheng, Cheng, additional, Reddick, Wilburn E., additional, and Conklin, Heather M., additional

Published
2016
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120. Prognostic factors that increase the risk for reduced white matter volumes and deficits in attention and learning for survivors of childhood cancers

Author

Reddick, Wilburn E., Taghipour, Delaram J., Glass, John O., Ashford, Jason, Xiong, Xiaoping, Wu, Shengjie, Bonner, Melanie, Khan, Raja B, and Conklin, Heather M.

Subjects
Male, Risk, Intelligence, Antineoplastic Agents, Neuropsychological Tests, Article, Leukoencephalopathies, Humans, Attention, Prospective Studies, Survivors, Child, Radiation Injuries, Injections, Spinal, Brain Neoplasms, Learning Disabilities, Age Factors, Brain, Organ Size, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Prognosis, Magnetic Resonance Imaging, Cross-Sectional Studies, Attention Deficit Disorder with Hyperactivity, Child, Preschool, Methylphenidate, Educational Status, Brain Damage, Chronic, Female, Cranial Irradiation, Follow-Up Studies
Abstract

In children, CNS-directed cancer therapy is thought to result in decreased cerebral white matter volumes (WMV) and subsequent neurocognitive deficits. This study was designed as a prospective validation of the purported reduction in WMV, associated influential factors, and its relationship to neurocognitive deficits in a very large cohort of both acute lymphoblastic leukemia (ALL) and malignant brain tumors (BT) survivors in comparison to an age similar cohort of healthy sibling controls.The effects of host characteristics and CNS treatment intensity on WMV were investigated in 383 childhood cancer survivors (199 ALL, 184 BT) at least 12 months post-completion of therapy and 67 healthy siblings that served as a control group. t-Tests and multiple variable linear models were used to assess cross-sectional WMV and its relation with neurocognitive function.BT survivors had lower WMV than ALL survivors, who had less than the control group. Increased CNS treatment intensity, younger age at treatment, and greater time since treatment were significantly associated with lower WMV. Additionally, cancer survivors did not perform as well as the control group on neurocognitive measures of intelligence, attention, and academic achievement. Reduced WMV had a larger impact on estimated IQ among females and children treated at a younger age.Survivors of childhood cancer that have undergone higher intensity therapy at a younger age have significantly less WMV than their peers and this difference increases with time since therapy. Decreased WMV is associated with significantly lower scores in intelligence, attention, and academic performance in survivors.

Published
2013

123. Evolution of neurocognitive function in long-term survivors of childhood acute lymphoblastic leukemia treated with chemotherapy only.

Author

Liu, Wei, primary, Cheung, Yin Ting, additional, Conklin, Heather M., additional, Jacola, Lisa M, additional, Pui, Ching-Hon, additional, Srivastava, Deokumar, additional, Nolan, Vikki G, additional, Zhang, Hongmei, additional, Gurney, James G, additional, Robison, Leslie L., additional, Hudson, Melissa M., additional, and Krull, Kevin R., additional

Published
2016
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124. Investigating the Role of Hypothalamic Tumor Involvement in Sleep and Cognitive Outcomes Among Children Treated for Craniopharyngioma

Author

Jacola, Lisa M., primary, Conklin, Heather M., additional, Scoggins, Matthew A., additional, Ashford, Jason M., additional, Merchant, Thomas E., additional, Mandrell, Belinda N., additional, Ogg, Robert J., additional, Curtis, Elizabeth, additional, Wise, Merrill S., additional, Indelicato, Daniel J., additional, and Crabtree, Valerie M., additional

Published
2016
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126. Computerized Cognitive Training for Amelioration of Cognitive Late Effects Among Childhood Cancer Survivors: A Randomized Controlled Trial

Author

Conklin, Heather M., primary, Ogg, Robert J., additional, Ashford, Jason M., additional, Scoggins, Matthew A., additional, Zou, Ping, additional, Clark, Kellie N., additional, Martin-Elbahesh, Karen, additional, Hardy, Kristina K., additional, Merchant, Thomas E., additional, Jeha, Sima, additional, Huang, Lu, additional, and Zhang, Hui, additional

Published
2015
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127. Slower Processing Speed after Treatment for Pediatric Brain Tumor and ALL

Author

Kahalley, Lisa S., Conklin, Heather M., Tyc, Vida L., Hudson, Melissa M., Wilson, Stephanie J., Wu, Shengjie, Xiong, Xiaoping, and Hinds, Pamela S.

Subjects
Male, Time Factors, Adolescent, Radiotherapy, Brain Neoplasms, Age Factors, Wechsler Scales, Antineoplastic Agents, Neuropsychological Tests, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Article, Sex Factors, Humans, Female, Survivors, Child, Cognition Disorders
Abstract

Acute lymphoblastic leukemia (ALL) and brain tumor (BT) survivors are at risk for post-treatment IQ declines. The extent to which lower scores represent global cognitive decline versus domain-specific impairment remains unclear. This study examined discrepancies between processing speed and estimated IQ (EIQ) scores and identified clinical characteristics associated with score discrepancies in a sample of pediatric cancer survivors.Survivors (50 ALL, 50 BT) ages 12-17 years completed cognitive testing. The Wechsler Abbreviated Scale of Intelligence provided an untimed measure of general reasoning ability (EIQ). The age-appropriate Wechsler Intelligence Scale provided a Processing Speed Index (PSI) score. Scores were examined and compared.Survivors' PSI scores were lower than their EIQ scores (BT t(45) =6.3, p0.001; ALL t(49) =6.9, p0.001). For BT survivors, lower PSI scores were associated with history of craniospinal irradiation, t(44) =3.3, p0.01. For ALL survivors, lower PSI scores were associated with male gender, grade retention, and time since diagnosis, F(3, 46) =10.1, p0.001. Clinically significant EIQ-PSI score discrepancies were identified in 41.3% of BT and 14.0% of ALL survivors.Many pediatric BT and ALL survivors exhibit slower processing speed than expected for age, whereas general reasoning ability remains largely intact. Risk factors associated with larger EIQ-PSI discrepancies include the following: BT diagnosis, craniospinal irradiation (BT only), male gender, and younger age at diagnosis (ALL only). Grade retention was frequent and associated with lower EIQ scores (both groups) and PSI scores (ALL only). Describing post-treatment cognitive declines using global measures of intellectual ability may underestimate dysfunction or fail to isolate specific underlying deficits contributing to impairment.

Published
2013

128. Returning research results: caregivers’ reactions following computerized cognitive training among childhood cancer survivors.

Author

Scott, Sarah M, Ashford, Jason M, Clark, Kellie N, Martin-Elbahesh, Karen, and Conklin, Heather M

Subjects
CHILDREN of cancer patients, COGNITIVE training, CAREGIVERS, LYMPHOBLASTIC leukemia, INSTITUTIONAL review boards, COMPUTER software
Abstract

Background Few researchers routinely disseminate results to participants; however, there is increasing acknowledgment that benefits of returning results outweigh potential risks. Our objective was to determine whether use of specific guidelines developed by the Children’s Oncology Group (COG) when preparing a lay summary would aid in understanding results. Specifically, to determine if caregivers of childhood cancer survivors found a lay summary comprehensive, easy to understand, and helpful following participation in a computerized cognitive training program. Methods In a previous study, 68 childhood survivors of acute lymphoblastic leukemia or brain tumor with identified cognitive deficits were randomly assigned to participate in a computerized cognitive intervention or assigned to a wait list. Following conclusion of this study, participants’ caregivers were contacted and provided with a summary of results based on COG guidelines and survey. Forty-three participants returned the surveys, examining caregivers’ interpretation of the summary, reaction to the results, and information regarding preference for receiving results. Results Caregivers reported results as important (93%), helpful (93%), easy to understand (98%), and relevant to their child (91%). They interpreted the results as generally positive, with many caregivers endorsing satisfaction (84%); however, concern of long-term implications was expressed (25%). Most preferred receiving results through postal letter (88%) or email (47%). Conclusions Benefits of returning research results to families appear to outweigh potential negative consequences. Returning results may help inform families when making future health care-related decisions. There is a great need to develop and assess the utility of guidelines for returning research results. [ABSTRACT FROM AUTHOR]

Published
2018
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129. Are the Psychological Needs of Adolescent Survivors of Pediatric Cancer Adequately Identified and Treated?

Author

Kahalley, Lisa S., Wilson, Stephanie J., Tyc, Vida L., Conklin, Heather M., Hudson, Melissa M., Wu, Shengjie, Xiong, Xiaoping, Stancel, Heather H., and Hinds, Pamela S.

Subjects
Male, Adolescent, Brain Neoplasms, Emotions, Behavioral Symptoms, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Article, Cohort Studies, Humans, Female, Survivors, Cranial Irradiation, Child, Cognition Disorders, Referral and Consultation, Needs Assessment
Abstract

To describe the psychological needs of adolescent survivors of acute lymphoblastic leukemia (ALL) or brain tumor (BT), we examined the following: (i) the occurrence of cognitive, behavioral, and emotional concerns identified during a comprehensive psychological evaluation and (ii) the frequency of referrals for psychological follow-up services to address identified concerns.Psychological concerns were identified on measures according to predetermined criteria for 100 adolescent survivors. Referrals for psychological follow-up services were made for concerns previously unidentified in formal assessment or not adequately addressed by current services.Most survivors (82%) exhibited at least one concern across domains: behavioral (76%), cognitive (47%), and emotional (19%). Behavioral concerns emerged most often on scales associated with executive dysfunction, inattention, learning, and peer difficulties. Cranial radiation therapy was associated with cognitive concerns, χ(2) (1, N = 100) = 5.63, p0.05. Lower income was associated with more cognitive concerns for ALL survivors, t(47) = 3.28, p0.01, and more behavioral concerns for BT survivors, t(48) = 2.93, p0.01. Of the survivors with concerns, 38% were referred for psychological follow-up services. Lower-income ALL survivors received more referrals for follow-up, χ(2) (1, N = 41) = 8.05, p0.01. Referred survivors had more concerns across domains than non-referred survivors, ALL: t(39) = 2.96, p0.01; BT: t(39) = 3.52, p0.01. Trends suggest ALL survivors may be at risk for experiencing unaddressed cognitive needs.Many adolescent survivors of cancer experience psychological difficulties that are not adequately managed by current services, underscoring the need for long-term surveillance. In addition to prescribing regular psychological evaluations, clinicians should closely monitor whether current support services appropriately meet survivors' needs, particularly for lower-income survivors and those treated with cranial radiation therapy.

Published
2012

130. ADHD and secondary ADHD criteria fail to identify many at-risk survivors of pediatric ALL and brain tumor

Author

Kahalley, Lisa S., Conklin, Heather M., Tyc, Vida L., Wilson, Stephanie J., Hinds, Pamela S., Wu, Shengjie, Xiong, Xiaoping, and Hudson, Melissa M.

Subjects
Male, Adolescent, Attention Deficit Disorder with Hyperactivity, Brain Neoplasms, Humans, Female, Precursor Cell Lymphoblastic Leukemia-Lymphoma, Child, Article, United States
Abstract

Post-treatment attention problems experienced by pediatric cancer survivors have been described as similar to symptoms of Attention-Deficit/Hyperactivity Disorder (ADHD) experienced in physically healthy children. Accordingly, the objectives of this study were to: (a) estimate the rate of occurrence of ADHD and secondary ADHD (SADHD) in a sample of pediatric cancer survivors, (b) compare the rate of ADHD/SADHD among survivors to the prevalence of ADHD in the general population, and (c) examine clinical correlates of ADHD/SADHD in this sample.Survivors of pediatric ALL or brain tumor (n = 100) participated in an assessment of attention including a Computerized Performance Measure [Conners' Continuous Performance test-II (CPT-II)], parent and self-report measures (Conners 3), and a structured diagnostic interview for ADHD and other psychological disorders [Diagnostic Interview for Children and Adolescents-IV (DICA-IV)].Binomial tests revealed that the rate of ADHD/SADHD in our sample (9%) was significantly greater than the lower limits of ADHD prevalence among children in the US (3%; P0.001), while no difference was identified compared to the upper limits of ADHD prevalence (7%; P0.05). Many additional survivors (25% of the sample) obtained clinical elevations on Conners 3 scales but did not meet ADHD/SADHD criteria.Attentional deficits experienced by pediatric cancer survivors do not appear to resemble the clinical presentation of ADHD or SADHD. Many survivors with cognitive and behavioral difficulties related to attention were not identified using this diagnostic approach. Findings offer needed clarification to guide researchers and clinicians in conceptualizing, assessing, and intervening on attentional late effects.

Published
2010

132. Feasibility and acceptability of a remotely administered computerized intervention to address cognitive late effects among childhood cancer survivors

Author

Cox, Lauren E., primary, Ashford, Jason M., additional, Clark, Kellie N., additional, Martin-Elbahesh, Karen, additional, Hardy, Kristina K., additional, Merchant, Thomas E., additional, Ogg, Robert J., additional, Jeha, Sima, additional, Willard, Victoria W., additional, Huang, Lu, additional, Zhang, Hui, additional, and Conklin, Heather M., additional

Published
2015
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137. Investigating the relationship between COMT polymorphisms and working memory performance among childhood brain tumor survivors

Author

Howarth, Robyn A., primary, Adamson, Amanda M., additional, Ashford, Jason M., additional, Merchant, Thomas E., additional, Ogg, Robert J., additional, Schulenberg, Stefan E., additional, Ogg, Susan, additional, Li, Jiang, additional, Wu, Shengjie, additional, Xiong, Xiaoping, additional, and Conklin, Heather M., additional

Published
2013
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143. Author Correction: A joint international consensus statement for measuring quality of survival for patients with childhood cancer

Author

van Kalsbeek, Rebecca J., Hudson, Melissa M., Mulder, Renée L., Ehrhardt, Matthew, Green, Daniel M., Mulrooney, Daniel A., Hakkert, Jessica, den Hartogh, Jaap, Nijenhuis, Anouk, van Santen, Hanneke M., Schouten-van Meeteren, Antoinette Y. N., van Tinteren, Harm, Verbruggen, Lisanne C., Conklin, Heather M., Jacola, Lisa M., Webster, Rachel Tillery, Partanen, Marita, Kollen, Wouter J. W., Grootenhuis, Martha A., Pieters, Rob, and Kremer, Leontien C. M.

Published
2023
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145. Survival and long-term health and cognitive outcomes after low-grade glioma

Author

Armstrong, Gregory T., primary, Conklin, Heather M., additional, Huang, Sujuan, additional, Srivastava, Deokumar, additional, Sanford, Robert, additional, Ellison, David W., additional, Merchant, Thomas E., additional, Hudson, Melissa M., additional, Hoehn, Mary Ellen, additional, Robison, Leslie L., additional, Gajjar, Amar, additional, and Morris, E. Brannon, additional

Published
2010
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146. Long-Term Efficacy of Methylphenidate in Enhancing Attention Regulation, Social Skills, and Academic Abilities of Childhood Cancer Survivors

Author

Conklin, Heather M., primary, Reddick, Wilburn E., additional, Ashford, Jason, additional, Ogg, Susan, additional, Howard, Scott C., additional, Morris, E. Brannon, additional, Brown, Ronald, additional, Bonner, Melanie, additional, Christensen, Robbin, additional, Wu, Shengjie, additional, Xiong, Xiaoping, additional, and Khan, Raja B., additional

Published
2010
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