3,826 results on '"Colonna P"'
Search Results
102. Intermolecular interactions and the weakly bound precursor states of elementary physicochemical processes
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Pirani, Fernando, Falcinelli, Stefano, Vecchiocattivi, Franco, Aquilanti, Vincenzo, Laricchiuta, Annarita, Colonna, Gianpiero, and Capitelli, Mario
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- 2023
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103. Understanding the SARS-CoV-2–Human Liver Interactome Using a Comprehensive Analysis of the Individual Virus–Host Interactions
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Giovanni Colonna
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COVID-19 ,COVID-19 molecular mechanisms ,SARS-CoV-2 ,liver interactome ,ribosome ,liver proteome during COVID-19 ,Medicine (General) ,R5-920 - Abstract
Many metabolic processes at the molecular level support both viral attack strategies and human defenses during COVID-19. This knowledge is of vital importance in the design of antiviral drugs. In this study, we extracted 18 articles (2021–2023) from PubMed reporting the discovery of hub nodes specific for the liver during COVID-19, identifying 142 hub nodes. They are highly connected proteins from which to obtain deep functional information on viral strategies when used as functional seeds. Therefore, we evaluated the functional and structural significance of each of them to endorse their reliable use as seeds. After filtering, the remaining 111 hubs were used to obtain by STRING an enriched interactome of 1111 nodes (13,494 interactions). It shows the viral strategy in the liver is to attack the entire cytoplasmic translational system, including ribosomes, to take control of protein biosynthesis. We used the SARS2-Human Proteome Interaction Database (33,791 interactions), designed by us with BioGRID data to implement a reverse engineering process that identified human proteins actively interacting with viral proteins. The results show 57% of human liver proteins are directly involved in COVID-19, a strong impairment of the ribosome and spliceosome, an antiviral defense mechanism against cellular stress of the p53 system, and, surprisingly, a viral capacity for multiple protein attacks against single human proteins that reveal underlying evolutionary–topological molecular mechanisms. Viral behavior over time suggests different molecular strategies for different organs.
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- 2024
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104. Flat-band hybridization between f and d states near the Fermi energy of SmCoIn5
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David W. Tam, Nicola Colonna, Fatima Alarab, Vladimir N. Strocov, Dariusz Jakub Gawryluk, Ekaterina Pomjakushina, and Michel Kenzelmann
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Materials of engineering and construction. Mechanics of materials ,TA401-492 ,Atomic physics. Constitution and properties of matter ,QC170-197 - Abstract
Abstract We present high-quality angle-resolved photoemission (ARPES) and density functional theory calculations (DFT+U) of SmCoIn5. We find broad agreement with previously published studies of LaCoIn5 and CeCoIn5 1,2, confirming that the Sm 4f electrons are mostly localized. Nevertheless, our model is consistent with an additional delocalized Sm component, stemming from hybridization between the 4f electrons and the metallic bands at “hot spot” positions in the Brillouin zone. The dominant hot spot, called γ Z , is similar to a source of delocalized f states found in previous experimental and theoretical studies of CeCoIn5 1,3. In this work, we identify and focus on the role of the Co d states in exploring the relationship between heavy quasiparticles and the magnetic interactions in SmCoIn5, which lead to a magnetically ordered ground state from within an intermediate valence scenario4–6. Specifically, we find a globally flat band consisting of Co d states near E = − 0.7 eV, indicating the possibility of enhanced electronic and magnetic interactions in the “115” family of materials through localization in the Co layer, and we discuss a possible origin in geometric frustration. We also show that the delocalized Sm 4f states can hybridize directly with the Co 3d x z /3d y z orbitals, which occurs in our model at the Brillouin zone boundary point R in a band that is locally flat and touches the Fermi level from above. Our work identifies microscopic ingredients for additional magnetic interactions in the “115” materials beyond the RKKY mechanism, and strongly suggests that the Co d bands are an important ingredient in the formation of both magnetic and superconducting ground states.
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- 2024
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105. Airborne Radiometric Surveys and Machine Learning Algorithms for Revealing Soil Texture
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Maino, Andrea, Alberi, Matteo, Anceschi, Emiliano, Chiarelli, Enrico, Cicala, Luca, Colonna, Tommaso, De Cesare, Mario, Guastaldi, Enrico, Lopane, Nicola, Mantovani, Fabio, Marcialis, Maurizio, Martini, Nicola, Montuschi, Michele, Piccioli, Silvia, Raptis, Kassandra Giulia Cristina, Russo, Antonio, Semenza, Filippo, and Strati, Virginia
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Physics - Geophysics - Abstract
Soil texture is key information in agriculture for improving soil knowledge and crop performance, so the accurate mapping of this crucial feature is imperative for rationally planning cultivations and for targeting interventions. We studied the relationship between radioelements and soil texture in the Mezzano Lowland (Italy), a 189 $km^2$ agricultural plain investigated through a ded-icated airborne gamma-ray spectroscopy survey. The K and Th abundances were used to retrieve the clay and sand content by means of a multi-approach method. Linear (simple and multiple) and non-linear (machine learning algorithms with deep neural networks) predictive models were trained and tested adopting a 1:50,000 scale soil texture map. The comparison of these approaches highlighted that the non-linear model introduces significant improvements in the prediction of soil texture fractions. The predicted maps of the clay and of the sand content were compared with the regional soil maps. Although the macro-structures were equally present, the airborne gam-ma-ray data permits us shedding light on finer features. Map areas with higher clay content were coincident with paleo-channels crossing the Mezzano Lowland in Etruscan and Roman periods, confirmed by the hydrographic setting of historical maps and by the geo-morphological features of the study area., Comment: 18 pages, 9 figures, 3 tables, correspondence to Andrea Maino via email at maino@fe.infn.it
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- 2022
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106. Advances and new ideas for neutron-capture astrophysics experiments at CERN n_TOF
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Domingo-Pardo, C., Babiano-Suarez, V., Balibrea-Correa, J., Caballero, L., Ladarescu, I., Lerendegui-Marco, J., Tain, J. L., Tarifeño-Saldivia, A., Aberle, O., Alcayne, V., Altieri, S., Amaducci, S., Andrzejewski, J., Bacak, M., Beltrami, C., Bennett, S., Bernardes, A. P., Berthoumieux, E., Boromiza, M., Bosnar, D., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Casanovas, A., Cerutti, F., Cescutti, G., Chasapoglou, S., Chiaveri, E., Chiera, N. M., Colombetti, P., Colonna, N., Camprini, P. Console, Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., Dellmann, S., Di Castro, M., Di Maria, S., Diakaki, M., Dietz, M., Dressler, R., Dupont, E., Durán, I., Eleme, Z., Fargier, S., Fernández, B., Fernández-Domínguez, B., Finocchiaro, P., Fiore, S., Furman, V., García-Infantes, F., Gawlik-Ramiega, A., Gervino, G., Gilardoni, S., González-Romero, E., Guerrero, C., Gunsing, F., Gustavino0, C., Heyse, J., Hillman, W., Jenkins, D. G., Jericha, E., Junghans, A., Kadi, Y., Kaperoni, K., Käppeler, F., Kaur, G., Kimura, A., Knapová, I., Koester, U., Kokkoris, M., Kopatch, Y., Krtička, M., Kyritsis, N., Lederer-Woods, C., Lerner, G., Manna, A., Martínez, T., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Maugeri, E. A., Mazzone, A., Mendoza, E., Mengoni, A., Milazzo, P. M., Mönch, I., Mucciola, R., Murtas, F., Musacchio-Gonzalez, E., Musumarra, A., Negret, A., de Rada, A. Pérez, Pérez-Maroto, P., Patronis, N., Pavón-Rodríguez, J. A., Pellegriti, M. G., Perkowski, J., Petrone, C., Pirovano, E., Plaza, J., Pomp, S., Porras, I., Praena, J., Quesada, J. M., Reifarth, R., Rochman, D., Romanets, Y., Rubbia, C., Sánchez, A., Sabaté-Gilarte, M., Schillebeeckx, P., Schumann, D., Sekhar, A., Smith, A. G., Sosnin, N. V., Stamati, M., Sturniolo, A., Tagliente, G., Tarrío, D., Torres-Sánchez, P., Turko, J., Urlass, S., Vagena, E., Valenta, S., Variale, V., Vaz, P., Vecchio, G., Vescovi, D., Vlachoudis, V., Vlastou, R., Wallner, T., Woods, P. J., Wright, T., Zarrella, R., and Žugec, P.
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Nuclear Experiment - Abstract
This article presents a few selected developments and future ideas related to the measurement of $(n,\gamma)$ data of astrophysical interest at CERN n_TOF. The MC-aided analysis methodology for the use of low-efficiency radiation detectors in time-of-flight neutron-capture measurements is discussed, with particular emphasis on the systematic accuracy. Several recent instrumental advances are also presented, such as the development of total-energy detectors with $\gamma$-ray imaging capability for background suppression, and the development of an array of small-volume organic scintillators aimed at exploiting the high instantaneous neutron-flux of EAR2. Finally, astrophysics prospects related to the intermediate $i$ neutron-capture process of nucleosynthesis are discussed in the context of the new NEAR activation area., Comment: preprint submitted to the European Physical Journal A, 11 pages, 4 figures
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- 2022
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107. Hypercyclicity of composition operators on discrete weighted Banach spaces
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Allen, Robert F., Colonna, Flavia, Martínez-Avendaño, Rubén A., and Pons, Matthew A.
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Mathematics - Functional Analysis ,primary: 47B33, 47A16, secondary: 47B38 - Abstract
In this paper, we study the hypercyclic composition operators on weighted Banach spaces of functions defined on discrete metric spaces. We show that the only such composition operators act on the "little" spaces. We characterize the bounded composition operators on the little spaces, as well as provide various necessary conditions for hypercyclicity.
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- 2022
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108. Multiplication operators between Lipschitz-type spaces on a tree
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Allen, Robert F., Colonna, Flavia, and Easley, Glenn R.
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Mathematics - Functional Analysis ,primary: 47B38, secondary: 05C05 - Abstract
Let $\mathcal{L}$ be the space of complex-valued functions $f$ on the set of vertices $T$ of an rooted infinite tree rooted at $o$ such that the difference of the values of $f$ at neighboring vertices remains bounded throughout the tree, and let $\mathcal{L}_{\textbf{w}}$ be the set of functions $f\in \mathcal{L}$ such that $|f(v)-f(v^-)|=O(|v|^{-1})$, where $|v|$ is the distance between $o$ and $v$ and $v^-$ is the neighbor of $v$ closest to $o$. In this article, we characterize the bounded and the compact multiplication operators between $\mathcal{L}$ and $\mathcal{L}_{\textbf{w}}$, and provide operator norm and essential norm estimates. Furthermore, we characterize the bounded and compact multiplication operators between $\mathcal{L}_{\textbf{w}}$ and the space $L^\infty$ of bounded functions on $T$ and determine their operator norm and their essential norm. We establish that there are no isometries among the multiplication operators between these spaces.
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- 2022
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109. Multiplication operators on the weighted Lipschitz space of a tree
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Allen, Robert F., Colonna, Flavia, and Easley, Glenn R.
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Mathematics - Functional Analysis ,primary: 47B38, secondary: 05C05 - Abstract
We study the multiplication operators on the weighted Lipschitz space $\mathcal{L}_{\textbf{w}}$ consisting of the complex-valued functions $f$ on the set of vertices of an infinite tree $T$ rooted at $o$ such that $\sup_{v\neq o}|v||f(v)-f(v^-)|<\infty$, where $|v|$ denotes the distance between $o$ and $v$ and $v^-$ is the neighbor of $v$ closest to $o$. For the multiplication operator, we characterize boundedness, compactness, provide estimates on the operator norm and the essential norm, and determine the spectrum. We prove that there are no isometric multiplication operators or isometric zero divisors on $\mathcal{L}_{\textbf{w}}$., Comment: arXiv admin note: text overlap with arXiv:2207.12212
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- 2022
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110. Weighted composition operators on the Bloch space of a bounded homogeneous domain
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Allen, Robert F. and Colonna, Flavia
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Mathematics - Complex Variables ,Mathematics - Functional Analysis ,primary: 47B38, seconday: 32A18, 30D45 - Abstract
In this paper, we present the current results in the study of weighted composition operators on the Bloch space of bounded homogeneous domains in $\mathbb{C}^n$ with particular emphasis on the issues of boundedness and compactness. We also discuss the bounded and the compact weighted composition operators from the Bloch space to the Hardy space $H^\infty$.
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- 2022
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111. Multiplication operators between iterated logarithmic Lipschitz spaces of a tree
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Allen, Robert F., Colonna, Flavia, and Prudhom, Andrew
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Mathematics - Functional Analysis ,primary: 47B38, 05C05 - Abstract
In this article, we characterize the bounded and the compact multiplication operators between distinct iterated logarithmic Lipschitz spaces, and between the Lipschitz space and an iterated logarithmic Lipschitz space of an infinite tree. In addition, we provide operator norm estimates and show that there are no isometries among such operators. %We obtain a new characterization of the bounded multiplication operators acting on an iterated logarithmic Lipschitz space and the compact multiplication operators between the weighted Lipschitz space and the Lipschitz space.
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- 2022
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112. Multiplication operators on the iterated logarithmic Lipschitz spaces of a tree
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Allen, Robert F., Colonna, Flavia, and Easley, Glenn R.
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Mathematics - Functional Analysis ,primary: 47B38, 05C05 - Abstract
We introduce a class of iterated logarithmic Lipschitz spaces $\mathcal{L}^{(k)}$, $k\in\mathbb{N}$, on an infinite tree which arise naturally in the context of operator theory. We characterize boundedness and compactness of the multiplication operators on $\mathcal{L}^{(k)}$ and provide estimates on their operator norm and their essential norm. In addition, we determine the spectrum, characterize the multiplication operators that are bounded below, and prove that on such spaces there are no nontrivial isometric multiplication operators and no isometric zero divisors.
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- 2022
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113. Weighted composition operators from $H^\infty$ to the Bloch space of a bounded homogeneous domain
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Allen, Robert F. and Colonna, Flavia
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Mathematics - Functional Analysis ,primary: 47B38, secondary: 32A18, 30D45 - Abstract
Let $D$ be a bounded homogeneous domain in $\mathbb{C}^n$. In this paper, we study the bounded and the compact weighted composition operators mapping the Hardy space $H^\infty(D)$ into the Bloch space of $D$. We characterize the bounded weighted composition operators, provide operator norm estimates, and give sufficient conditions for compactness. We prove that these conditions are necessary in the case of the unit ball and the polydisk. We then show that if $D$ is a bounded symmetric domain, the bounded multiplication operators from $H^\infty(D)$ to the Bloch space of $D$ are the operators whose symbol is bounded.
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- 2022
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114. Bag of Tricks for Long-Tail Visual Recognition of Animal Species in Camera-Trap Images
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Cunha, Fagner, Santos, Eulanda M. dos, and Colonna, Juan G.
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Computer Science - Computer Vision and Pattern Recognition - Abstract
Camera traps are a method for monitoring wildlife and they collect a large number of pictures. The number of images collected of each species usually follows a long-tail distribution, i.e., a few classes have a large number of instances, while a lot of species have just a small percentage. Although in most cases these rare species are the ones of interest to ecologists, they are often neglected when using deep-learning models because these models require a large number of images for the training. In this work, a simple and effective framework called Square-Root Sampling Branch (SSB) is proposed, which combines two classification branches that are trained using square-root sampling and instance sampling to improve long-tail visual recognition, and this is compared to state-of-the-art methods for handling this task: square-root sampling, class-balanced focal loss, and balanced group softmax. To achieve a more general conclusion, the methods for handling long-tail visual recognition were systematically evaluated in four families of computer vision models (ResNet, MobileNetV3, EfficientNetV2, and Swin Transformer) and four camera-trap datasets with different characteristics. Initially, a robust baseline with the most recent training tricks was prepared and, then, the methods for improving long-tail recognition were applied. Our experiments show that square-root sampling was the method that most improved the performance for minority classes by around 15%; however, this was at the cost of reducing the majority classes' accuracy by at least 3%. Our proposed framework (SSB) demonstrated itself to be competitive with the other methods and achieved the best or the second-best results for most of the cases for the tail classes; but, unlike the square-root sampling, the loss in the performance of the head classes was minimal, thus achieving the best trade-off among all the evaluated methods.
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- 2022
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115. Analysis of one-neutron transfer reaction in $^{18}$O + $^{76}$Se collision at 275 MeV
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Ciraldo, I., Cappuzzello, F., Cavallaro, M., Carbone, D., Burrello, S., Spatafora, A., Gargano, A., De Gregorio, G., Vsevolodovna, R. I. Magaña, Acosta, L., Agodi, C., Amador-Valenzuela, P., Borello-Lewin, T., Brischetto, G. A., Calabrese, S., Calvo, D., Capirossi, V., Lomelí, E. R. Chávez, Colonna, M., Delaunay, F., Djapo, H., Eke, C., Finocchiaro, P., Firat, S., Fisichella, M., Foti, A., Hacisalihoglu, A., Iazzi, F., La Fauci, L., Linares, R., Medina, N. H., Moralles, M., Oliveira, J. R. B., Pakou, A., Pandola, L., Petrascu, H., Pinna, F., Russo, G., Santopinto, E., Sgouros, O., Guazzelli, M. A., Solakci, S. O., Soukeras, V., Souliotis, G., Torresi, D., Tudisco, S., Yildirim, A., and Zagatto, V. A. B.
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Nuclear Experiment ,Nuclear Theory - Abstract
Purpose: We want to analyze transitions to low-lying excited states of the residual and ejectile nuclei in the 76Se(18O, 17O) 77Se one-neutron stripping reaction at 275-MeV incident energy and determine the role of single-particle and core excitation in the description of the measured cross sections. In addition, we explore the sensitivity of the calculated cross section to different nuclear structure models. Methods: The excitation energy spectrum and the differential cross-section angular distributions are measured using the MAGNEX large acceptance magnetic spectrometer for the detection of the ejectiles and the missing mass technique for the reconstruction of the reaction kinematics. The data are compared with calculations based on distorted-wave Born approximation, coupled-channels Born approximation, and coupled reaction channels adopting spectroscopic amplitudes for the projectile and target overlaps derived by large-scale shell-model calculations and interacting boson-fermion model. Results: Peaks in the energy spectra corresponding to groups of unresolved transitions to 77Se and 17O are identified. The experimental cross sections are extracted and compared to theoretical calculations. A remarkable agreement is found, without using any scaling factors, demonstrating that the adopted models for nuclear structure and reaction take into account the relevant aspects of the studied processes. The main transitions which contribute to the cross section of each peak are identified., Comment: 15 pages, 4 figures
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- 2022
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116. Development and experimental evaluation of surface enhancement methods for laser powder directed energy deposition microchannels
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Paul Gradl, Angelo Cervone, and Piero Colonna
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Directed energy deposition, microchannels, surface enhancements, polishing, roughness, flow testing ,Science ,Manufactures ,TS1-2301 - Abstract
ABSTRACTThis research evaluates Laser Powder Directed Energy Deposition (LP-DED) for producing fine feature internal microchannels. This study is focused on enhancing and characterising the surfaces of microchannels produced using techniques such as abrasive flow machining, chemical milling, chemical mechanical polishing, electrochemical machining, and thermal energy method to modify internal surfaces of microchannels made from NASA HR-1 Fe-Ni-Cr alloy. Flow testing for discharge coefficient measurement is conducted on processed microchannel samples, followed by characterisation through optical microscopy, Scanning Electron Microscopy (SEM), and Computed Tomography. Findings reveal variations in surfaces due to powder adherence, melt pool undulations, and polishing mechanisms. The study emphasises the significance of removing material equivalent to the mean powder diameter to reduce surface roughness and impact the discharge coefficient. The research proposes a ratio for planarising roughness and waviness peak height and density, offering insights for tailored surface adjustments in specific applications requiring reduced flow resistance.HighlightsInternal microchannels with thin-walls were fabricated using the laser powder directed energy deposition process.Various surface enhancements and polishing processes were developed to modify the surface texture of the LP-DED channels.Flow testing was conducted to determine the discharge coefficient.Post-test characterisation was completed to obtain cross sectional area, perimeter, surface texture, and general surface condition to analyse results.Ratio of roughness and waviness peak and density (Spk/Spd and Wp/WPc) is proposed as a relevant surface characterisation parameter.Tailored surface modifications for specific end-use applications.
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- 2024
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117. Hyperbaric oxygen augments susceptibility to C. difficile infection by impairing gut microbiota ability to stimulate the HIF-1α-IL-22 axis in ILC3
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José L. Fachi, Laís. P. Pral, Helder C. Assis, Sarah Oliveira, Vinícius R. Rodovalho, Jefferson A. C. dos Santos, Mariane F. Fernandes, Valquíria A. Matheus, Renata Sesti-Costa, Paulo J. Basso, Marina Flóro e Silva, Niels O. S. Câmara, Selma Giorgio, Marco Colonna, and Marco A. R. Vinolo
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Hyperbaric oxygen ,microbiota ,butyrate ,clostridioides difficile ,innate lymphoid cells ,ILC3 ,Diseases of the digestive system. Gastroenterology ,RC799-869 - Abstract
ABSTRACTHyperbaric oxygen (HBO) therapy is a well-established method for improving tissue oxygenation and is typically used for the treatment of various inflammatory conditions, including infectious diseases. However, its effect on the intestinal mucosa, a microenvironment known to be physiologically hypoxic, remains unclear. Here, we demonstrated that daily treatment with hyperbaric oxygen affects gut microbiome composition, worsening antibiotic-induced dysbiosis. Accordingly, HBO-treated mice were more susceptible to Clostridioides difficile infection (CDI), an enteric pathogen highly associated with antibiotic-induced colitis. These observations were closely linked with a decline in the level of microbiota-derived short-chain fatty acids (SCFAs). Butyrate, a SCFA produced primarily by anaerobic microbial species, mitigated HBO-induced susceptibility to CDI and increased epithelial barrier integrity by improving group 3 innate lymphoid cell (ILC3) responses. Mice displaying tissue-specific deletion of HIF-1 in RORγt-positive cells exhibited no protective effect of butyrate during CDI. In contrast, the reinforcement of HIF-1 signaling in RORγt-positive cells through the conditional deletion of VHL mitigated disease outcome, even after HBO therapy. Taken together, we conclude that HBO induces intestinal dysbiosis and impairs the production of SCFAs affecting the HIF-1α-IL-22 axis in ILC3 and worsening the response of mice to subsequent C. difficile infection.
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- 2024
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118. TREM2-independent microgliosis promotes tau-mediated neurodegeneration in the presence of ApoE4.
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Gratuze, Maud, Schlachetzki, Johannes, DOliveira Albanus, Ricardo, Jain, Nimansha, Novotny, Brenna, Brase, Logan, Rodriguez, Lea, Mansel, Clayton, Kipnis, Michal, OBrien, Sydney, Pasillas, Martina, Lee, Choonghee, Manis, Melissa, Colonna, Marco, Harari, Oscar, Glass, Christopher, Ulrich, Jason, and Holtzman, David
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Alzheimer’s disease ,ApoE4 ,TREM2 ,microgliosis ,tau pathology ,tau-mediated neurodegeneration ,Mice ,Animals ,Apolipoprotein E4 ,Alzheimer Disease ,Inflammation ,Microglia ,Disease Models ,Animal ,Membrane Glycoproteins ,Receptors ,Immunologic - Abstract
In addition to tau and Aβ pathologies, inflammation plays an important role in Alzheimers disease (AD). Variants in APOE and TREM2 increase AD risk. ApoE4 exacerbates tau-linked neurodegeneration and inflammation in P301S tau mice and removal of microglia blocks tau-dependent neurodegeneration. Microglia adopt a heterogeneous population of transcriptomic states in response to pathology, at least some of which are dependent on TREM2. Previously, we reported that knockout (KO) of TREM2 attenuated neurodegeneration in P301S mice that express mouse Apoe. Because of the possible common pathway of ApoE and TREM2 in AD, we tested whether TREM2 KO (T2KO) would block neurodegeneration in P301S Tau mice expressing ApoE4 (TE4), similar to that observed with microglial depletion. Surprisingly, we observed exacerbated neurodegeneration and tau pathology in TE4-T2KO versus TE4 mice, despite decreased TREM2-dependent microgliosis. Our results suggest that tau pathology-dependent microgliosis, that is, TREM2-independent microgliosis, facilitates tau-mediated neurodegeneration in the presence of ApoE4.
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- 2023
119. Aggregation tests identify new gene associations with breast cancer in populations with diverse ancestry
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Mueller, Stefanie H, Lai, Alvina G, Valkovskaya, Maria, Michailidou, Kyriaki, Bolla, Manjeet K, Wang, Qin, Dennis, Joe, Lush, Michael, Abu-Ful, Zomoruda, Ahearn, Thomas U, Andrulis, Irene L, Anton-Culver, Hoda, Antonenkova, Natalia N, Arndt, Volker, Aronson, Kristan J, Augustinsson, Annelie, Baert, Thais, Freeman, Laura E Beane, Beckmann, Matthias W, Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blomqvist, Carl, Bogdanova, Natalia V, Bojesen, Stig E, Bonanni, Bernardo, Brenner, Hermann, Brucker, Sara Y, Buys, Saundra S, Castelao, Jose E, Chan, Tsun L, Chang-Claude, Jenny, Chanock, Stephen J, Choi, Ji-Yeob, Chung, Wendy K, Colonna, Sarah V, Cornelissen, Sten, Couch, Fergus J, Czene, Kamila, Daly, Mary B, Devilee, Peter, Dörk, Thilo, Dossus, Laure, Dwek, Miriam, Eccles, Diana M, Ekici, Arif B, Eliassen, A Heather, Engel, Christoph, Evans, D Gareth, Fasching, Peter A, Fletcher, Olivia, Flyger, Henrik, Gago-Dominguez, Manuela, Gao, Yu-Tang, García-Closas, Montserrat, García-Sáenz, José A, Genkinger, Jeanine, Gentry-Maharaj, Aleksandra, Grassmann, Felix, Guénel, Pascal, Gündert, Melanie, Haeberle, Lothar, Hahnen, Eric, Haiman, Christopher A, Håkansson, Niclas, Hall, Per, Harkness, Elaine F, Harrington, Patricia A, Hartikainen, Jaana M, Hartman, Mikael, Hein, Alexander, Ho, Weang-Kee, Hooning, Maartje J, Hoppe, Reiner, Hopper, John L, Houlston, Richard S, Howell, Anthony, Hunter, David J, Huo, Dezheng, Ito, Hidemi, Iwasaki, Motoki, Jakubowska, Anna, Janni, Wolfgang, John, Esther M, Jones, Michael E, Jung, Audrey, Kaaks, Rudolf, Kang, Daehee, Khusnutdinova, Elza K, Kim, Sung-Won, Kitahara, Cari M, Koutros, Stella, Kraft, Peter, Kristensen, Vessela N, Kubelka-Sabit, Katerina, Kurian, Allison W, Kwong, Ava, Lacey, James V, Lambrechts, Diether, and Le Marchand, Loic
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Breast Cancer ,Genetics ,Clinical Research ,Cancer ,Aetiology ,2.1 Biological and endogenous factors ,Humans ,Female ,Breast Neoplasms ,Genetic Predisposition to Disease ,Black People ,Genetic Testing ,Genome-Wide Association Study ,Polymorphism ,Single Nucleotide ,Formins ,Breast cancer susceptibility ,Diverse ancestry ,Rare variants ,Gene regulation ,Genome-wide association study ,NBCS Collaborators ,CTS Consortium ,ABCTB Investigators ,Clinical Sciences - Abstract
BackgroundLow-frequency variants play an important role in breast cancer (BC) susceptibility. Gene-based methods can increase power by combining multiple variants in the same gene and help identify target genes.MethodsWe evaluated the potential of gene-based aggregation in the Breast Cancer Association Consortium cohorts including 83,471 cases and 59,199 controls. Low-frequency variants were aggregated for individual genes' coding and regulatory regions. Association results in European ancestry samples were compared to single-marker association results in the same cohort. Gene-based associations were also combined in meta-analysis across individuals with European, Asian, African, and Latin American and Hispanic ancestry.ResultsIn European ancestry samples, 14 genes were significantly associated (q
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- 2023
120. Atomic and molecular data and their applications: ICAMDATA 2022
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Laricchiuta, Annarita, Gordon, Iouli E., Hill, Christian, Colonna, Gianpiero, and Ptasinska, Sylwia
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- 2024
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121. Measurement of the prompt fission γ235-rays from slow neutron-induced fission of γ235U with STEFF
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Wright, T., Smith, A. G., Sosnin, N. V., Bennett, S. A., Davies, P. J., Popescu, A. V., Ryan, J. A., Sekhar, A., Warren, S., Aberle, O., Amaducci, S., Andrzejewski, J., Audouin, L., Bacak, M., Balibrea, J., Barbagallo, M., Bečvář, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Cerutti, F., Chen, Y. H., Chiaveri, E., Colonna, N., Cortés, G., Cortés-Giraldo, M. A., Cosentino, L., Damone, L. A., Diakaki, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Finocchiaro, P., Furman, V., Göbel, K., García, A. R., Gawlik-Ramięga, A., Gilardoni, S., Glodariu, T., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Harada, H., Heinitz, S., Heyse, J., Jenkins, D. G., Jericha, E., Käppeler, F., Kadi, Y., Kalamara, A., Kavrigin, P., Kimura, A., Kivel, N., Kokkoris, M., Krtička, M., Kurtulgil, D., Leal-Cidoncha, E., Lederer-Woods, C., Leeb, H., Lerendegui-Marco, J., Meo, S. Lo, Lonsdale, S. J., Macina, D., Manna, A., Marganiec, J., Martínez, T., Masi, A., Massimi, C., Mastinu, P., Mastromarco, M., Maugeri, E. A., Mazzone, A., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Rauscher, T., Reifarth, R., Rubbia, C., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Sedyshev, P., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tassan-Got, L., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Weiss, C., Woods, P. J., and Žugec, P.
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- 2024
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122. Advancements in 3D In Vitro Models for Colorectal Cancer
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Sara Vitale, Federica Calapà, Francesca Colonna, Francesca Luongo, Mauro Biffoni, Ruggero De Maria, and Micol E. Fiori
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colorectal cancer ,patient‐derived organoids ,preclinical models for cancer ,tumor microenvironment ,Science - Abstract
Abstract The process of drug discovery and pre‐clinical testing is currently inefficient, expensive, and time‐consuming. Most importantly, the success rate is unsatisfactory, as only a small percentage of tested drugs are made available to oncological patients. This is largely due to the lack of reliable models that accurately predict drug efficacy and safety. Even animal models often fail to replicate human‐specific pathologies and human body's complexity. These factors, along with ethical concerns regarding animal use, urge the development of suitable human‐relevant, translational in vitro models.
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- 2024
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123. Willingness to Pay for Blueberries: Sensory Attributes, Fruit Quality Traits, and Consumers’ Characteristics
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Elizabeth Canales, R. Karina Gallardo, Massimo Iorizzo, Patricio Munoz, Luis Felipe Ferrão, Claire Luby, Nahla Bassil, Marti Pottorff, Penelope Perkins-Veazie, Paul Sandefur, Ann Colonna, and Charles Sims
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consumer preferences ,firmness ,flavor ,quality traits ,sensory analysis ,Plant culture ,SB1-1110 - Abstract
Understanding consumers’ preferences for fruit quality attributes is key to informing breeding efforts, meeting consumer preferences, and promoting increased market demand. The objective of this study was to assess the effect of fruit quality traits and hedonic sensory evaluation on consumers’ willingness to pay (WTP) for a selection of fresh northern and southern highbush blueberry cultivars. The WTP was elicited by using a double-bounded contingent valuation conducted in conjunction with a consumer sensory test. Two types of models were estimated using either sensory evaluations (i.e., consumer preference and consumer intensity) or instrumental measurement data (i.e., measures of soluble solids, titratable acidity, sugars, acids, and firmness) as explanatory variables to model WTP. Results using sensory evaluations indicated that flavor liking, flavor intensity, and sweetness intensity are key factors that influence consumers’ acceptance and WTP for blueberries. A regression analysis using instrumental measurements indicated that measures related to sweetness and acidity traits are important factors that determine WTP. Higher WTP was associated with higher total sugar content across different levels of total organic acid. The WTP increases with organic acid content, because this is needed for enhanced flavor; however, WTP declines at high concentrations of organic acid. Except for extreme values of firmness, the WTP increased as measures of fruit firmness increased, indicating a consumer preference for firmer blueberries. Overall, the results provided new insights into the relationships between consumer preference and WTP and fruit quality benchmarks to select for improved quality.
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- 2024
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124. A novel tool for modeling the near- and far-field dispersion of brine effluent from desalination plants
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Silvano Porto Pereira, Melissa Fontenelle Rodrigues, Paulo Cesar Colonna Rosman, Patrícia Rosman, Tobias Bleninger, Iran Eduardo Lima Neto, Carlos E. P. Teixeira, Iván Sola, and José Luis Sánchez Lizaso
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brine dilution ,desalination discharge ,Lagrangian model ,near-field model ,negative buoyancy ,outfall modeling ,Science ,General. Including nature conservation, geographical distribution ,QH1-199.5 - Abstract
Regardless of the specific technology adopted, the use of desalination to produce fresh water from seawater results in a discharge of brine effluent containing a high concentration of salts and other desalination by-products that must be dealt with appropriately. Until now, this effluent has most commonly been discharged into the sea through a submarine outfall. Computational tools are used to simulate the behavior of these brine discharges to minimize their impact on the marine environment. Environmental assessments of desalination plants that are made using these tools can include consideration of the rates of effluent production and flow, diffuser configurations, marine conditions (e.g., currents, tides, salinity, temperature), and the proximity of plants to environmentally significant areas. Computational tools can also assist in the design of programs for monitoring the surroundings of brine disposal points. In this study, we developed a new tool for modeling brine discharges from submarine outfalls based on an adaptation of a near-field mathematical model coupled with a Lagrangian model. This new model was specifically designed for application to negatively buoyant effluent discharges. The near-field dilution results that were obtained for various current velocities and different diffuser vertical inclinations using this tool were compared with those obtained using a reference tool (Visual Plumes), considering four different desalination plants. Excellent correlation and a mean absolute percentage error lower than 10% were obtained between the two sets of results along with good reproducibility. Additionally, the existence of an integrated wave propagation model in the simulation software allowed the analysis of changes in the brine plume direction produced by waves formed far from the outfall area. Using the new model, it was possible to evaluate how the diffuser configuration affected the performance of the diffuser line, and the saline plume generated by the combined Lagrangian and near-field model realistically reproduced the behavior of a submarine brine outfall. This combined model is potentially applicable to a range of other situations, including studies that aim to minimize the environmental impact of desalination plants based on considerations of outfall locations and optimization of the diffuser configuration.
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- 2024
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125. Long Acting Reversible Contraception After Surgical Abortion With High Rate of Continuation and Patients’ Satisfaction
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Paola Algeri, Laura Imbruglia, Laura Colonna, Vanda Savoldi, Nunzia Mastrocola, and Silvia von Wunster
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Abortion ,Contraception ,Long-Acting Reversible Contraception ,Gynecology and obstetrics ,RG1-991 - Abstract
Objective: In Italy the percentage of repeated abortions is about 24%. Long-acting reversible contraceptive (LARC) methods are currently considered the most effective mode worldwide and are associated with the highest rate of 12-months continuation, with a potential reported reduction of recurrent abortions. The aim of this study was evaluating LARC continuation and the patients’ satisfaction at two and twelve months in use. Materials and methods: A longitudinal observational study collected women who underwent surgical abortion and placed a LARC method at the time of abortion in our hospital. Results: Totally 828 women underwent surgical abortion during the study period from which 434 choose a LARC method. After two months the rate of continuation of 52mg LNG IUD was 100% in women presenting for follow-up. Continuation rate at one year was approximately 70% for all LARC methods. More than 70% of women declared themselves satisfied or very satisfied with all LARC methods. Conclusion: Despite a high rate of patient loss at follow-up, LARC methods showed a high rate of continuation at two and twelve months, with a high degree of patients' satisfaction.
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- 2024
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126. Periprocedural Edoxaban Management and Clinical Outcomes in Patients Undergoing Transcatheter Cardiovascular Procedures in the EMIT-AF/VTE Program
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Martin Unverdorben MD, PhD, Paolo Colonna MD, James Jin PhD, Sabine Köhler PhD, Amparo Santamaria MD, PhD, Manish Saxena MBBS, Amanda Borrow PhD, Cathy Chen MD, Christian von Heymann MD, PhD, and Thomas Vanassche MD
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Diseases of the circulatory (Cardiovascular) system ,RC666-701 - Abstract
Annually, 10% of patients with atrial fibrillation (AF) or venous thromboembolism (VTE) treated with non-vitamin K oral anticoagulants undergo diagnostic or therapeutic procedures. This subanalysis of the multicenter, prospective, observational Edoxaban Management in Diagnostic and Therapeutic Procedures real-world registry included patients in Europe and Asia with AF or VTE who underwent transcatheter cardiovascular (CV) procedures. Edoxaban interruption and clinical outcomes were assessed for all arterial or venous access procedures and stratified by bleeding risk. Overall, 2695 procedures were reported; 755 (28.0%) were transcatheter CV procedures, of which 373 (49.4%) were arterial access and 382 (50.6%) were venous access procedures. Patients with arterial versus venous access procedures had significantly higher bleeding and stroke and thromboembolism risk scores ( P < 0.0001 for both) and underwent procedures that were more frequently classified as having a higher European Heart Rhythm Association bleeding risk. Edoxaban was interrupted in 59.5% (222) arterial versus 42.4% (162) venous access procedures, mostly either only preprocedurally or both pre- and postprocedurally. The combined incidence of clinically relevant ischemic or bleeding event rates and deaths was low (0.8 events/100 procedures). This subanalysis showed that while edoxaban was interrupted in approximately half of all interventions, ischemic events and major bleeding were low, suggesting transcatheter CV procedures can be performed safely in high-risk patients with AF or VTE. Patient and procedural factors should be considered to personalize the decision of edoxaban management around the time of a transcatheter CV procedure. Clinical trial registration number: NCT02950168, NCT02951039
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- 2024
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127. Mechanical recycling of foam from end-of-life mattresses by AIR-LAY process for the production of new mattresses with a fully circular approach
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G. Liberati, F. Biagi, A. Nanni, M.F. Parisi, L. Barbaresi, L. Querci, S. Ceccarelli, M. Regazzi, A. Bonoli, and M. Colonna
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Mechanical recycling ,End-of-life ,Mattresses ,Air-lay process ,Circular economy ,Materials of engineering and construction. Mechanics of materials ,TA401-492 - Abstract
A novel method for the recycling of end-of-life mattresses foam, using an AIR-LAY process which employs a bi-component fiber as a binder for the polyurethane foam, have been developed and optimized. This method permits to obtain materials with the same density of the starting foam (25 kg/m3) and with a significantly lower density with respect to that obtainable with the rebonding process (above 70 kg/m3) that uses isocyanates to bond the foam particles. The obtained recycled foams have been tested by mechanical compression and recovery tests showing that compression values of 3.7 KPa, similar to that of the mattress foam (3.0 KPa), can be achieved using 20 % of bi-component fibers as binders and a density of 35 kg/m3. On the contrary, only 3 times stiffer and denser materials can be obtained using the rebonding technology, thus making them not suitable for application in mattresses. On the basis of the results of the optimization tests a set of mattresses containing a layer of the recycled foams have been prepared. The results of the tests on the prepared mattresses have shown that they have the same compression behavior, recovery time and durability (after 30,000 cycles of compression) of a standard mattress without the recycled layer, thus proving that a fully circular approach in the recycling of the foam of the mattresses is possible using the AIR-LAY process.
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- 2024
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128. Variability of the declared recycled content by changing allocation methods: A case study on plastic waste recycling
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Francesco Caraceni, Elisabetta Abbate, Carlo Brondi, Martino Colonna, Giovanni Dotelli, and Andrea Ballarino
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Circular economy ,Plastic waste recycling ,Mass balance ,Recycled content ,Traceability ,Chain of Custody ,Environmental sciences ,GE1-350 ,Environmental effects of industries and plants ,TD194-195 - Abstract
The Chain of Custody (CoC) standard tracks the recycled content (RC) of products, in most cases using the Mass Balance model. This model freely allows the selection of allocation methods and timeframes for the RC evaluation. Our work opens a discussion on the potential effects of this freedom in the RC evaluation. Firstly, we defined the general model representing the viable allocation methods and timeframe, and secondly, we applied the model to a case study. The mass balance model simplifies the monitoring of RC and encourages companies to use recycled materials. However, we outline the need for actions on stricter RC calculation and reporting, for instance, by reducing the timeframe of mass balance calculation or promoting the controlled blending model, which guarantees the physical presence of RC in the product. The results provide a basis for policymakers to set requirements for RC evaluation.
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- 2024
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129. Machine learning based event classification for the energy-differential measurement of the $^\text{nat}$C(n,p) and $^\text{nat}$C(n,d) reactions
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Žugec, P., Barbagallo, M., Andrzejewski, J., Perkowski, J., Colonna, N., Bosnar, D., Gawlik, A., Sabate-Gilarte, M., Bacak, M., Mingrone, F., and Chiaveri, E.
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Physics - Data Analysis, Statistics and Probability ,Computer Science - Computer Vision and Pattern Recognition ,Nuclear Experiment - Abstract
The paper explores the feasibility of using machine learning techniques, in particular neural networks, for classification of the experimental data from the joint $^\text{nat}$C(n,p) and $^\text{nat}$C(n,d) reaction cross section measurement from the neutron time of flight facility n_TOF at CERN. Each relevant $\Delta E$-$E$ pair of strips from two segmented silicon telescopes is treated separately and afforded its own dedicated neural network. An important part of the procedure is a careful preparation of training datasets, based on the raw data from Geant4 simulations. Instead of using these raw data for the training of neural networks, we divide a relevant 3-parameter space into discrete voxels, classify each voxel according to a particle/reaction type and submit these voxels to a training procedure. The classification capabilities of the structurally optimized and trained neural networks are found to be superior to those of the manually selected cuts., Comment: 11 pages, 5 figures, 2 tables
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- 2022
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130. Interplay between surface and volume instabilities in heavy-ion collisions examined within mean-field extensions
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Napolitani, P., Viet, H. Dinh, and Colonna, M.
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Nuclear Theory - Abstract
In the transition from nuclear matter to finite nuclei, complex finite-size effects which characterise open systems arise, in relation with either the nuclear surface or the bulk. In addition, the non-equilibrium character of the process, typical of violent heavy-ion collisions (from Fermi energy to the intermediate-energy domain) adds up as well. The resulting dynamics is the combination of surface and volume unstable modes which trigger large-amplitude fluctuations. A rich variety of fragmentation patterns may emerge, ranging from collimated streams of nuclear clusters to the split of a stretched nuclear complex into few large fragments. They imply different conditions of density and surface tension, and result in different chronologies. Such phenomenology has been observed in experiments, but it is often difficult to recognise and disentangle the underlying types of instabilities. To draw some example, two extremely deformed nuclear systems, produced below and above Fermi energy, are chosen and followed microscopically all along their evolution within the Boltzmann-Langevin One-Body approach., Comment: International Workshop on Multi facets of Eos and Clustering IWM-EC, Caen, 23-26 November 2021
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- 2022
131. Microglia states and nomenclature: A field at its crossroads
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Paolicelli, Rosa C, Sierra, Amanda, Stevens, Beth, Tremblay, Marie-Eve, Aguzzi, Adriano, Ajami, Bahareh, Amit, Ido, Audinat, Etienne, Bechmann, Ingo, Bennett, Mariko, Bennett, Frederick, Bessis, Alain, Biber, Knut, Bilbo, Staci, Blurton-Jones, Mathew, Boddeke, Erik, Brites, Dora, Brône, Bert, Brown, Guy C, Butovsky, Oleg, Carson, Monica J, Castellano, Bernardo, Colonna, Marco, Cowley, Sally A, Cunningham, Colm, Davalos, Dimitrios, De Jager, Philip L, de Strooper, Bart, Denes, Adam, Eggen, Bart JL, Eyo, Ukpong, Galea, Elena, Garel, Sonia, Ginhoux, Florent, Glass, Christopher K, Gokce, Ozgun, Gomez-Nicola, Diego, González, Berta, Gordon, Siamon, Graeber, Manuel B, Greenhalgh, Andrew D, Gressens, Pierre, Greter, Melanie, Gutmann, David H, Haass, Christian, Heneka, Michael T, Heppner, Frank L, Hong, Soyon, Hume, David A, Jung, Steffen, Kettenmann, Helmut, Kipnis, Jonathan, Koyama, Ryuta, Lemke, Greg, Lynch, Marina, Majewska, Ania, Malcangio, Marzia, Malm, Tarja, Mancuso, Renzo, Masuda, Takahiro, Matteoli, Michela, McColl, Barry W, Miron, Veronique E, Molofsky, Anna Victoria, Monje, Michelle, Mracsko, Eva, Nadjar, Agnes, Neher, Jonas J, Neniskyte, Urte, Neumann, Harald, Noda, Mami, Peng, Bo, Peri, Francesca, Perry, V Hugh, Popovich, Phillip G, Pridans, Clare, Priller, Josef, Prinz, Marco, Ragozzino, Davide, Ransohoff, Richard M, Salter, Michael W, Schaefer, Anne, Schafer, Dorothy P, Schwartz, Michal, Simons, Mikael, Smith, Cody J, Streit, Wolfgang J, Tay, Tuan Leng, Tsai, Li-Huei, Verkhratsky, Alexei, von Bernhardi, Rommy, Wake, Hiroaki, Wittamer, Valérie, Wolf, Susanne A, Wu, Long-Jun, and Wyss-Coray, Tony
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Microglia ,Neurosciences ,Psychology ,Cognitive Sciences ,Neurology & Neurosurgery - Abstract
Microglial research has advanced considerably in recent decades yet has been constrained by a rolling series of dichotomies such as "resting versus activated" and "M1 versus M2." This dualistic classification of good or bad microglia is inconsistent with the wide repertoire of microglial states and functions in development, plasticity, aging, and diseases that were elucidated in recent years. New designations continuously arising in an attempt to describe the different microglial states, notably defined using transcriptomics and proteomics, may easily lead to a misleading, although unintentional, coupling of categories and functions. To address these issues, we assembled a group of multidisciplinary experts to discuss our current understanding of microglial states as a dynamic concept and the importance of addressing microglial function. Here, we provide a conceptual framework and recommendations on the use of microglial nomenclature for researchers, reviewers, and editors, which will serve as the foundations for a future white paper.
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- 2022
132. Intense exercise increases dopamine transporter and neuromelanin concentrations in the substantia nigra in Parkinson’s disease
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Bart de Laat, Jocelyn Hoye, Gelsina Stanley, Michelle Hespeler, Jennifer Ligi, Varsha Mohan, Dustin W. Wooten, Xiaomeng Zhang, Thanh D. Nguyen, Jose Key, Giulia Colonna, Yiyun Huang, Nabeel Nabulsi, Amar Patel, David Matuskey, Evan D. Morris, and Sule Tinaz
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Neurology. Diseases of the nervous system ,RC346-429 - Abstract
Abstract Parkinson’s disease (PD) is characterized by a progressive loss of dopaminergic neurons. Exercise has been reported to slow the clinical progression of PD. We evaluated the dopaminergic system of patients with mild and early PD before and after a six-month program of intense exercise. Using 18F-FE-PE2I PET imaging, we measured dopamine transporter (DAT) availability in the striatum and substantia nigra. Using NM-MRI, we evaluated the neuromelanin content in the substantia nigra. Exercise reversed the expected decrease in DAT availability into a significant increase in both the substantia nigra and putamen. Exercise also reversed the expected decrease in neuromelanin concentration in the substantia nigra into a significant increase. These findings suggest improved functionality in the remaining dopaminergic neurons after exercise. Further research is needed to validate our findings and to pinpoint the source of any true neuromodulatory and neuroprotective effects of exercise in PD in large clinical trials.
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- 2024
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133. The hidden scabies: a rare case of atypical Norwegian scabies, case report and literature review
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Angela Mauro, Cristiana Colonna, Silvia Taranto, Vittoria Garella, Francesca Castelletti, Laura Giordano, Nicola Adriano Monzani, and Luca Bernardo
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Scabies ,Children ,Norwegian scabies ,Down syndrome ,Immunodepression ,Pediatrics ,RJ1-570 - Abstract
Abstract Background Norwegian scabies is a rare dermatological manifestation that usually affects the most fragile populations, such as elderly and immunocompromised patients, and its diagnosis is quite complex, due to its low prevalence in the general population and because of a broad spectrum manifestation. Case Presentation Here we describe a rare case of Norwegian scabies that was previously misdiagnosed in a sixteen year old patient affected by Down syndrome and we conducted a non-systematic literature review about this topic. Lesions were atypical, pruritic and associated with periodic desquamation of the palms and soles and after a series of specialist evaluations, she finally underwent topical treatment with complete remission. Conclusion It is therefore crucial to take in consideration the relation between Down syndrome and community acquired crusted scabies, to enable preventative measures, early detection, and proper treatment.
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- 2024
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134. Koopmans spectral functionals in periodic-boundary conditions
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Colonna, Nicola, De Gennaro, Riccardo, Linscott, Edward, and Marzari, Nicola
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Condensed Matter - Materials Science ,Physics - Computational Physics - Abstract
Koopmans spectral functionals aim to describe simultaneously ground state properties and charged excitations of atoms, molecules, nanostructures and periodic crystals. This is achieved by augmenting standard density functionals with simple but physically motivated orbital-density-dependent corrections. These corrections act on a set of localized orbitals that, in periodic systems, resemble maximally localized Wannier functions. At variance with the original, direct supercell implementation [Phys. Rev. X 8, 021051 (2018)], we discuss here i) the complex but efficient formalism required for a periodic-boundary code using explicit Brillouin zone sampling, and ii) the calculation of the screened Koopmans corrections with density-functional perturbation theory. In addition to delivering improved scaling with system size, the present development makes the calculation of band structures with Koopmans functionals straightforward. The implementation in the open-source Quantum ESPRESSO distribution and the application to prototypical insulating and semiconducting systems are presented and discussed.
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- 2022
135. Transport Model Comparison Studies of Intermediate-Energy Heavy-Ion Collisions
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Wolter, Hermann, Colonna, Maria, Cozma, Dan, Danielewicz, Pawel, Ko, Che Ming, Kumar, Rohit, Ono, Akira, Tsang, ManYee Betty, Xu, Jun, Zhang, Ying-Xun, Bratkovskaya, Elena, Feng, Zhao-Qing, Gaitanos, Theodoros, Fèvre, Arnaud Le, Ikeno, Natsumi, Kim, Youngman, Mallik, Swagata, Napolitani, Paolo, Oliinychenko, Dmytro, Ogawa, Tatsuhiko, Papa, Massimo, Su, Jun, Wang, Rui, Wang, Yong-Jia, Weil, Janus, Zhang, Feng-Shou, Zhang, Guo-Qiang, Zhang, Zhen, Aichelin, Joerg, Cassing, Wolfgang, Chen, Lie-Wen, Cheng, Hui-Gan, Elfner, Hannah, Gallmeister, K., Hartnack, Christoph, Hashimoto, Shintaro, Jeon, Sangyong, Kim, Kyungil, Kim, Myungkuk, Li, Bao-An, Lee, Chang-Hwan, Li, Qing-Feng, Li, Zhu-Xia, Mosel, Ulrich, Nara, Yasushi, Niita, Koji, Ohnishi, Akira, Sato, Tatsuhiko, Song, Taesoo, Sorensen, Agnieszka, Wang, Ning, and Xie, Wen-Jie
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Nuclear Theory ,Nuclear Experiment - Abstract
Transport models are the main method to obtain physics information from low to relativistic-energy heavy-ion collisions. The Transport Model Evaluation Project (TMEP) has been pursued to test the robustness of transport model predictions in reaching consistent conclusions from the same type of physical model. Calculations under controlled conditions of physical input and set-up were performed with various participating codes. These included both calculations of nuclear matter in a box with periodic boundary conditions, and more realistic calculations of heavy-ion collisions. In this intermediate review, we summarize and discuss the present status of the project. We also provide condensed descriptions of the 26 participating codes, which contributed to some part of the project. These include the major codes in use today. We review the main results of the studies completed so far. They show, that in box calculations the differences between the codes can be well understood and a convergence of the results can be reached. These studies also highlight the systematic differences between the two families of transport codes, known as BUU and QMD type codes. However, when the codes were compared in full heavy-ion collisions using different physical models, as recently for pion production, they still yielded substantially different results. This calls for further comparisons of heavy-ion collisions with controlled models and of box comparisons of important ingredients, like momentum-dependent fields, which are currently underway. We often indicate improved strategies in performing transport simulations and thus provide guidance to code developers. Results of transport simulations of heavy-ion collisions from a given code will have more significance if the code can be validated against benchmark calculations such as the ones summarized in this review., Comment: 114 pages, 14 figures, 479 references, accepted for publication in Progress of Particle and Nuclear Phsics
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- 2022
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136. Multi-channel experimental and theoretical constraints for the $^{116}$Cd($^{20}$Ne,$^{20}$F)$^{116}$In charge exchange reaction at 306 MeV
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Burrello, S., Calabrese, S., Cappuzzello, F., Carbone, D., Cavallaro, M., Colonna, M., Lay, J. A., Lenske, H., Agodi, C., Ferreira, J. L., Firat, S., Hacisalihoglu, A., La Fauci, L., Spatafora, A., Acosta, L., Bellone, J. I., Borello-Lewin, T., Boztosun, I., Brischetto, G. A., Calvo, D., Chávez-Lomelí, E. R., Ciraldo, I., Cutuli, M., Delaunay, F., Finocchiaro, P., Fisichella, M., Foti, A., Iazzi, F., Lanzalone, G., Linares, R., Lubian, J., Moralles, M., Oliveira, J. R. B., Pakou, A., Pandola, L., Petrascu, H., Pinna, F., Russo, G., Sgouros, O., Solakci, S. O., Soukeras, V., Souliotis, G., Torresi, D., Tudisco, S., Yildirin, A., and Zagatto, V. A. B.
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Nuclear Theory ,Nuclear Experiment - Abstract
Charge exchange (CE) reactions offer a major opportunity to excite nuclear isovector modes, providing clues about the nuclear interaction in the medium. Moreover, double charge exchange (DCE) reactions are proving to be a tempting tool to access nuclear transition matrix elements (NME) related to double beta-decay processes. Through a multi-channel experimental analysis and a consistent theoretical approach of the $^{116}$Cd($^{20}$Ne,$^{20}$F)$^{116}$In single charge exchange (SCE) reaction at 306 MeV, we aim at disentangling from the experimental cross section the contribution of the competing mechanisms, associated with second or higher order sequential transfer and inelastic processes. We measured excitation energy spectra and absolute cross sections for elastic + inelastic, one-proton transfer and SCE channels, using the MAGNEX large acceptance magnetic spectrometer to detect the ejectiles. For the first two channels, we also extracted the experimental cross section angular distributions. The experimental data are compared with theoretical predictions obtained by performing two-step distorted wave Born approximation and coupled reaction channel calculations. We employ spectroscopic amplitudes for single-particle transitions derived within a large-scale shell model approach and different optical potentials for modeling the initial and the final state interactions. The present study significantly mitigates the possible model dependence existing in the description of these complex reaction mechanisms, thanks to the reproduction of several channels at once. In particular, our work demonstrates that the two-step transfer mechanisms produce a non negligible contribution to the total cross section of the $^{116}$Cd($^{20}$Ne,$^{20}$F)$^{116}$In reaction channel, although a relevant fraction is still missing, being ascribable to the direct SCE mechanism, which is not addressed here., Comment: 21 pages, 11 figures
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- 2022
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137. High accuracy, high resolution 235U(n,f) cross section from n_TOF (CERN) in the thermal to 10 keV energy range
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collaboration, n_TOF, Mastromarco, M., Amaducci, S., Colonna, N., Finocchiaro, P., Cosentino, L., Aberle, O., Andrzejewski, J., Audouin, L., Bacak, M., Balibrea, J., Barbagallo, M., Bečvář, F., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A., Caamaño, M., Calviño, F., Calviani, M., Cano-Ott, D., Cardella, R., Casanovas, A., Cerutti, F., Chen, Y. H., Chiaveri, E., Cortés, G., Cortés-Giraldo, M. A., Damone, L. A., Diakaki, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Fernández-Domínguez, B., Ferrari, A., Ferreira, P., Furman, V., Göbel, K., García, A. R., Gawlik, A., Gilardoni, S., Glodariu, T., Gonçalves, I. F., González-Romero, E., Griesmayer, E., Guerrero, C., Gunsing, F., Harada, H., Heinitz, S., Heyse, J., Jenkins, D. G., Jericha, E., Käppeler, F., Kadi, Y., Kalamara, A., Kavrigin, P., Kimura, A., Kivel, N., Knapova, I., Kokkoris, M., Krtička, M., Kurtulgil, D., Leal-Cidoncha, E., Lederer, C., Leeb, H., Lerendegui-Marco, J., Meo, S. Lo, Lonsdale, S. J., Macina, D., Manna, A., Marganiec, J., Martínez, T., Masi, A., Massimi, C., Mastinu, P., Maugeri, E. A., Mazzone, A., Mendoza, E., Mengoni, A., Milazzo, P. M., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Rauscher, T., Reifarth, R., Rubbia, C., Ryan, J. A., Sabaté-Gilarte, M., Saxena, A., Schillebeeckx, P., Schumann, D., Sedyshev, P., Smith, A. G., Sosnin, N. V., Stamatopoulos, A., Tagliente, G., Tain, J. L., Tarifeño-Saldivia, A., Tassan-Got, L., Valenta, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Warren, S., Weiss, C., Woods, P. J., Wright, T., and Žugec, P.
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Nuclear Experiment - Abstract
The 235U(n,f) cross section was measured in a wide energy range (25 meV - 170 keV) at the n_TOF facility at CERN, relative to 6Li(n,t) and 10B(n,alpha) standard reactions, with high resolution and accuracy, with a setup based on a stack of six samples and six silicon detectors placed in the neutron beam. In this paper we report on the results in the region between thermal and 10 keV neutron energy. A resonance analysis has been performed up to 200 eV, with the code SAMMY. The resulting fission kernels are compared with the ones extracted on the basis of the resonance parameters of the most recent major evaluated data libraries. A comparison of the n_TOF data with the evaluated cross sections is also performed from thermal to 10 keV neutron energy for the energy-averaged cross section in energy groups of suitably chosen width. A good agreement is found in average between the new results and the latest evaluated data files ENDF-B/VIII and JEFF-3.3, as well as with respect to the IAEA reference files. However, some discrepancies are still present in some specific energy regions. The new dataset here presented, characterized by unprecedented resolution and accuracy, can help improving the evaluations in the Resolved Resonance Region and up to 10 keV, and reduce the uncertainties that affect this region.
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- 2022
138. (Pre)diabetes and a higher level of glycaemic measures are continuously associated with corneal neurodegeneration assessed by corneal confocal microscopy: the Maastricht Study
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Mokhtar, Sara B. A., van der Heide, Frank C. T., Oyaert, Karel A. M., van der Kallen, Carla J. H., Berendschot, Tos T. J. M., Scarpa, Fabio, Colonna, Alessia, de Galan, Bastiaan E., van Greevenbroek, Marleen M. J., Dagnelie, Pieter C., Schalkwijk, Casper G., Nuijts, Rudy M. M. A., Schaper, Nicolaas C., Kroon, Abraham A., Schram, Miranda T., Webers, Carroll A. B., and Stehouwer, Coen D. A.
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- 2023
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139. Combined subcutaneous implantable cardioverter defibrillator and pacemaker devices in complex congenital heart disease: a single-center experienced based study
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Sarubbi, Berardo, Ciriello, Giovanni Domenico, Papaccioli, Giovanni, Correra, Anna, Romeo, Emanuele, Grimaldi, Nicola, Colonna, Diego, and Palma, Michela
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- 2023
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140. The biology of TREM receptors
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Colonna, Marco
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- 2023
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141. Bringing door-to-needle times within the European benchmarks results in better stroke patients outcomes in a spoke hospital from the Apulian Region
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Giorelli, Maurizio, Leone, Ruggiero, Aniello, Maria Stella, Altomare, Sergio, Colonna, Isabella, Liuzzi, Daniele, Plasmati, Immacolata, Sardaro, Michele, Fioretto, Nicola, Di Paola, Giuseppe, Tatò, Emanuele, and Scelzi, Alessandro
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- 2023
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142. Management of edoxaban therapy and clinical outcomes in patients undergoing major or nonmajor surgery: a subanalysis of the EMIT-AF/VTE study
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Christian von Heymann, Martin Unverdorben, Paolo Colonna, Amparo Santamaria, Manish Saxena, Thomas Vanassche, Sabine Köhler, Amanda P. Borrow, James Jin, and Cathy Chen
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Periprocedural management ,Direct oral anticoagulation ,Edoxaban interruption ,Atrial fibrillation ,EMIT-AF/VTE ,Major Surgery ,Diseases of the blood and blood-forming organs ,RC633-647.5 - Abstract
Abstract Background Optimising periprocedural management of direct oral anticoagulation in patients with atrial fibrillation on chronic treatment undergoing major surgeries is an important aspect of balancing the risk of surgery-related bleeding with the risk of thromboembolic events, which may vary by surgery type. Methods This subanalysis of the prospective EMIT-AF/VTE programme assessed periprocedural-edoxaban management, according to physicians’ decisions, and bleeding and thromboembolic event rates in patients who underwent major vs. nonmajor surgeries. Edoxaban interruption and clinical outcomes were compared between major vs. nonmajor surgeries and between renal function subgroups (creatinine clearance [CrCL] ≤ 50 mL/min vs. > 50 mL/min). Results We included 276 major and 512 nonmajor surgeries. The median pre- and postprocedural duration of edoxaban interruption in major vs. nonmajor surgeries was 4 vs. 1 days, whereas median duration of interruption for those with preprocedural-only and postprocedural-only interruption was 2 vs. 1 days and 2 vs. 0 days, respectively (P
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- 2023
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143. TREM2 macrophages induced by human lipids drive inflammation in acne lesions
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Do, Tran H, Ma, Feiyang, Andrade, Priscila R, Teles, Rosane, de Andrade Silva, Bruno J, Hu, Chanyue, Espinoza, Alejandro, Hsu, Jer-En, Cho, Chun-Seok, Kim, Myungjin, Xi, Jingyue, Xing, Xianying, Plazyo, Olesya, Tsoi, Lam C, Cheng, Carol, Kim, Jenny, Bryson, Bryan D, O'Neill, Alan M, Colonna, Marco, Gudjonsson, Johann E, Klechevsky, Eynav, Lee, Jun Hee, Gallo, Richard L, Bloom, Barry R, Pellegrini, Matteo, and Modlin, Robert L
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Biomedical and Clinical Sciences ,Clinical Sciences ,Immunology ,Clinical Research ,Atherosclerosis ,2.1 Biological and endogenous factors ,Aetiology ,Acne Vulgaris ,Humans ,Inflammation ,Lipids ,Macrophages ,Membrane Glycoproteins ,Receptors ,Immunologic ,Squalene ,Clinical sciences - Abstract
Acne affects 1 in 10 people globally, often resulting in disfigurement. The disease involves excess production of lipids, particularly squalene, increased growth of Cutibacterium acnes, and a host inflammatory response with foamy macrophages. By combining single-cell and spatial RNA sequencing as well as ultrahigh-resolution Seq-Scope analyses of early acne lesions on back skin, we identified TREM2 macrophages expressing lipid metabolism and proinflammatory gene programs in proximity to hair follicle epithelium expressing squalene epoxidase. We established that the addition of squalene induced differentiation of TREM2 macrophages in vitro, which were unable to kill C. acnes. The addition of squalene to macrophages inhibited induction of oxidative enzymes and scavenged oxygen free radicals, providing an explanation for the efficacy of topical benzoyl peroxide in the clinical treatment of acne. The present work has elucidated the mechanisms by which TREM2 macrophages and unsaturated lipids, similar to their involvement in atherosclerosis, may contribute to the pathogenesis of acne.
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- 2022
144. Bloch's theorem in orbital-density-dependent functionals: Band structures from Koopmans spectral functionals
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De Gennaro, Riccardo, Colonna, Nicola, Linscott, Edward, and Marzari, Nicola
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Condensed Matter - Materials Science ,Physics - Computational Physics - Abstract
Koopmans-compliant functionals provide an orbital-density-dependent framework for an accurate evaluation of spectral properties; they are obtained by imposing a generalized piecewise-linearity condition on the total energy of the system with respect to the occupation of any orbital. In crystalline materials, due to the orbital-density-dependent nature of the functionals, minimization of the total energy to a ground state provides a set of minimizing variational orbitals that are localized and thus break the periodicity of the underlying lattice. Despite this, we show that Bloch symmetry can be preserved and it is possible to describe the electronic states with a band-structure picture, thanks to the Wannier-like character of the variational orbitals. We also present a method to unfold and interpolate the electronic bands from supercell ($\Gamma$-point) calculations, which enables us to calculate full band structures with Koopmans-compliant functionals. The results obtained for a set of benchmark semiconductors and insulators show very good agreement with state-of-the-art many-body perturbation theory and experiments, underscoring the reliability of these spectral functionals in predicting band structures., Comment: 34 pages, 4 figures
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- 2021
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145. Analysis of two-nucleon transfer reactions in the 20Ne + 116Cd system at 306 MeV
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Carbone, D., Ferreira, J. L., Calabrese, S., Cappuzzello, F., Cavallaro, M., Hacisalihoglu, A., Lenske, H., Lubian, J., Vsevolodovna, R. I. Magana, Santopinto, E., Agodi, C., Acosta, L., Bonanno, D., Borello-Lewin, T., Boztosun, I., Brischetto, G. A., Burrello, S., Calvo, D., Lomelí, E. R. Chávez, Ciraldo, I., Colonna, M., Delaunay, F., Deshmukh, N., Finocchiaro, P., Fisichella, M., Foti, A., Gallo, G., Iazzi, F., La Fauci, L., Lanzalone, G., Linares, R., Medina, N. H., Moralles, M., Oliveira, J. R. B., Pakou, A., Pandola, L., Petrascu, H., Pinna, F., Reito, S., Russo, G., Sgouros, O., Solakci, S. O., Soukeras, V., Souliotis, G., Spatafora, A., Torresi, D., Tudisco, S., Yildirin, A., and Zagatto, V. A. B.
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Nuclear Experiment ,Nuclear Theory - Abstract
Background: Heavy-ion induced two-nucleon transfer reactions are powerful tools to reveal peculiar aspects of the atomic nucleus, such as pairing correlations, single-particle and collective degrees of freedom, and more. Also, these processes are in competition with the direct meson exchange in the double charge exchange reactions, which have recently attracted great interest due to their possible connection to neutrinoless double-beta decay. In this framework, the exploration of two-nucleon transfer reactions in the 20Ne+116Cd collision at energies above the Coulomb barrier is particularly relevant since the 116Cd nucleus is a candidate for the double-beta decay. Methods: We measured the excitation energy spectra and absolute cross sections for the two reactions using the MAGNEX large acceptance magnetic spectrometer to detect the ejectiles. We performed direct coupled reaction channels and sequential distorted wave Born approximation calculations using the double folding S\~ao Paulo potential to model the initial and final state interactions. The spectroscopic amplitudes for two- and singleparticle transitions were derived by different nuclear structure approaches: microscopic large-scale shell model, interacting boson model-2 and quasiparticle random phase approximation. Results: The calculations are able to reproduce the experimental cross sections for both two-neutron and twoproton transfer reactions. The role of couplings with the inelastic channels are found to be important in the two-proton transfer case. A competition between the direct and the sequential process is found in the reaction mechanism. For the two-proton transfer case, the inclusion of the 1g7/2 and 2d5/2 orbitals in the model space is crucial.
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- 2021
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146. Atomic-level description of thermal fluctuations in inorganic lead halide perovskites
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Cannelli, Oliviero, Wiktor, Julia, Colonna, Nicola, Leroy, Ludmila, Puppin, Michele, Bacellar, Camila, Sadykov, Ilia, Krieg, Franziska, Smolentsev, Grigory, Kovalenko, Maksym V., Pasquarello, Alfredo, Chergui, Majed, and Mancini, Giulia F.
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Condensed Matter - Materials Science - Abstract
The potential of lead-halide perovskites for realistic applications is currently hindered by their limited long-term stability under functional activation. While the role of lattice flexibility in the thermal response of perovskites has become increasingly evident, the description of thermally-induced distortions is still unclear. In this work, we provide a unified picture of thermal activation in CsPbBr3 across length scales, showing that lattice symmetry does not increase at high temperatures. We combine temperature-dependent XRD, Br K-edge XANES, ab initio MD simulations, and calculations of the XANES spectra by first-principles, accounting for both thermal fluctuations and core hole final state effects. We find that the octahedral tilting of the Pb-Br inorganic framework statistically adopts multiple local configurations over time - in the short-range. In turn, the stochastic nature of the local thermal fluctuations uplifts the longer-range periodic octahedral tilting characterizing the low temperature structure, with the statistical mean of the local configurations resulting in a cubic-like time-averaged lattice. These observations can be rationalized in terms of displacive thermal phase transitions through the soft mode model, in which the phonon anharmonicity of the flexible inorganic framework causes the excess free energy surface to change as a function of temperature. Our work demonstrates that the effect of thermal dynamics on the XANES spectra can be effectively described for largely anharmonic systems, provided ab initio MD simulations are performed to determine the dynamically fluctuating structures, and core hole final state effects are included in order to retrieve an accurate XANES line shape. Moreover, it shows that the soft mode model, previously invoked to describe displacive thermal phase transitions in oxide perovskites, carries a more general validity.
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- 2021
147. Atomic structure of the single step and dynamics of Sn adatoms on the Si(111)-\sqrt{3}\times\sqrt{3}-Sn surface
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Zhachuk, R. A., Rogilo, D. I., Petrov, A. S., Sheglov, D. V., Latyshev, A. V., Colonna, S., and Ronci, F.
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Condensed Matter - Materials Science - Abstract
The atomic structure of well-ordered single steps on the Si(111)-\sqrt{3}\times\sqrt{3}-Sn surface and the dynamics of Sn adatoms in the vicinity of these steps was studied. The work was performed using low-temperature scanning tunneling microscopy (STM) and ab initio calculations based on the density-functional theory. The STM tip was used to record the tunneling current versus time on top of oscillating adatoms, keeping the feedback loop turned off. The dynamics of adatoms, detected as the telegraph noise present in the tunneling current, was registered near the steps at 80 K. The atomic structure model of the single steps consisting of Sn atomic chains along the steps was developed. This structure leads to the formation of potential double wells near the steps acting as traps for Sn atoms and explains the fluctuating current recorded in these areas., Comment: 9 pages, 8 figures
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- 2021
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148. High-resolution cross section measurements for neutron interactions on 89Y with incident neutron energies up to 95 keV
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Tagliente, G., Milazzo, P. M., Paradela, C., Kopecky, S., Vescovi, D., Alaerts, G., Damone, L. A., Heyse, J., Krtička, M., Schillebeeckx, P., Mengoni, A., Wynants, R., Valenta, S., Aberle, O., Alcayne, V., Amaducci, S., Andrzejewski, J., Audouin, L., Babiano-Suarez, V., Bacak, M., Barbagallo, M., Bécares, V., Bečvář, F., Bellia, G., Berthoumieux, E., Billowes, J., Bosnar, D., Brown, A. S., Busso, M., Caamaño, M., Caballero, L., Calviani, M., Calviño, F., Cano-Ott, D., Casanovas, A., Cerutti, F., Chen, Y. H., Chiaveri, E., Colonna, N., Cortés, G. P., Cortés-Giraldo, M. A., Cosentino, L., Cristallo, S., Diakaki, M., Dietz, M., Domingo-Pardo, C., Dressler, R., Dupont, E., Durán, I., Eleme, Z., Fernández-Domíngez, B., Ferrari, A., Ferro-Gonçalves, I., Finocchiaro, P., Furman, V., Garg, R., Gawlik, A., Gilardoni, S., Glodariu, T., Göbel, K., González-Romero, E., Guerrero, C., Gunsing, F., Heinitz, S., Jenkins, D. G., Jericha, E., Kadi, Y., Käppeler, F., Kimura, A., Kivel, N., Kokkoris, M., Kopatch, Y., Kurtulgil, D., Ladarescu, I., Larsen, A. C., Lederer-Woods, C., Lerendegui-Marco, J., Lo Meo, S., Lonsdale, S. J., Lugaro, M., Macina, D., Manna, A., Martínez, T., Masi, A., Massimi, C., Mastinu, P. F., Mastromarco, M., Matteucci, F., Maugeri, E., Mazzone, A., Mendoza, E., Michalopoulou, V., Mingrone, F., Musumarra, A., Negret, A., Nolte, R., Ogállar, F., Oprea, A., Patronis, N., Pavlik, A., Perkowski, J., Piersanti, L., Porras, I., Praena, J., Quesada, J. M., Radeck, D., Ramos Doval, D., Reifarth, R., Rochman, D., Rubbia, C., Sabaté-Gilarte, M., Saxena, A., Schumann, D., Smith, A. G., Spelta, M., Sosnin, N., Stamatopoulos, A., Tain, J. L., Talip, Z., Tarifeño-Saldivia, A. E., Tassan-Got, L., Torres-Sánchez, P., Tsinganis, A., Ulrich, J., Urlass, S., Vannini, G., Variale, V., Vaz, P., Ventura, A., Vlachoudis, V., Vlastou, R., Wallner, A., Woods, P. J., Wright, T. J., and Žugec, P.
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- 2024
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149. Management of edoxaban therapy and clinical outcomes in patients undergoing major or nonmajor surgery: a subanalysis of the EMIT-AF/VTE study
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von Heymann, Christian, Unverdorben, Martin, Colonna, Paolo, Santamaria, Amparo, Saxena, Manish, Vanassche, Thomas, Köhler, Sabine, Borrow, Amanda P., Jin, James, and Chen, Cathy
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- 2023
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150. Edoxaban use in the context of dental procedures: analysis from the EMIT-AF/VTE database
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Chen, Cathy, Saxena, Manish, von Heymann, Christian, Vanassche, Thomas, Jin, James, Lersch, Robert, Köhler, Sabine, Santamaria, Amparo, Unverdorben, Martin, and Colonna, Paolo
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- 2023
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