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105. Hippocampal-DMN disconnectivity in MS is related to WM lesions and depression

Author

Rocca, M, Pravata, E, Valsasina, P, Radaelli, M, Colombo, B, Vacchi, L, Gobbi, C, Comi, G, Falini, A, Filippi, M, Rocca M. A., Pravata E., Valsasina P., Radaelli M., Colombo B., Vacchi L., Gobbi C., Comi G., Falini A., Filippi M., Rocca, M, Pravata, E, Valsasina, P, Radaelli, M, Colombo, B, Vacchi, L, Gobbi, C, Comi, G, Falini, A, Filippi, M, Rocca M. A., Pravata E., Valsasina P., Radaelli M., Colombo B., Vacchi L., Gobbi C., Comi G., Falini A., and Filippi M.

Abstract

The hippocampus is part of the default-mode network (DMN) and is functionally hit early in multiple sclerosis (MS). Hippocampal and DMN dysfunctions have been associated with depression, both in patients with MS and in major depressive disorders. We hypothesized that white matter lesions may contribute, through a disconnection mechanism, to hippocampal dysfunction. To test this, we assessed the relationship between hippocampal resting-state (RS) functional connectivity (FC) abnormalities with brain T2 lesion volumes and the presence and severity of depression. Structural and RS fMRI images were acquired from 69 patients with cognitively intact MS and 42 matched healthy controls (HC). Depression was quantified using the Montgomery-Asberg Depression Rating Scale. Seed-voxel hippocampal RS FC was assessed. SPM8 was used for between-group comparisons and correlation analysis between RS FC abnormalities with clinical and structural MRI variables. Compared to HC, patients with MS showed a significant atrophy of the whole brain and left hippocampus (P<0.001), and a distributed pattern of decreased RS FC between the hippocampi and several cortical-subcortical regions, which were mostly located within the DMN. Reduced hippocampal RS FC with regions of the DMN was strongly correlated with higher T2 lesion volume, longer disease duration, and the severity of depression and disability. In patients with cognitively preserved MS, brain focal WM lesions are related to the functional integration of the hippocampus to other brain regions of the DMN, suggesting a disconnection syndrome. Such a disruption of hippocampal RS FC is likely to contribute to the occurrence of depression and to clinical disability. Hum Brain Mapp 36:5051-5063, 2015.

Published
2015

107. Music interventions for neurodevelopmental disorders

Author

Antonietti, Alessandro, Colombo, Barbara, Derocher, B. R., Antonietti A. (ORCID:0000-0002-7212-8076), Colombo B. (ORCID:0000-0002-4095-9633), Antonietti, Alessandro, Colombo, Barbara, Derocher, B. R., Antonietti A. (ORCID:0000-0002-7212-8076), and Colombo B. (ORCID:0000-0002-4095-9633)

Abstract

Music therapy interventions for Autism, ADHD and Rett syndrome

Published
2018

108. Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone

Author

Martinelli, V., Cocco, E., Capra, R., Salemi, G., Gallo, P., Capobianco, M., Pesci, I., Ghezzi, A., Pozzilli, Carlo, Lugaresi, A., Bellantonio, P., Amato, M. P., Grimaldi, L. M., Trojano, M., Mancardi, G. L., Bergamaschi, R., Gasperini, Claudio, Rodegher, M., Straffi, L., Ponzio, M., Comi, G., For The Italian Mitoxantrone Group, Radaelli, M, Esposito, F, Moiola, L, Colombo, B, Rossi, P, Marrosu, Mg, Frau, J, Lorefice, L, Coghe, G, Savettieri, Giovanni, Ragonese, P, Cusimano, V, Perini, P, Rinaldi, F, Vidali, A, Bertolotto, A, Malucchi, S, Di Sapio, A, Montanari, E, Guareschi, A, Rizzo, A, Zaffaroni, M, Baldini, S, De Rossi, N, Cordioli, C, Rasia, S, Salvetti, M, Buttinelli, C, AUSILI CEFARO, Luca, De Luca, G, Tommaso, D, Farina, D, Fantozzi, R, Ruggieri, S, Amato, Mp, Hakiki, B, Zipoli, V, Portaccio, E, Bartolozzi, Ml, Scandellari, C, Stecchi, S, Marchello, Lp, Palmeri, B, Vitello, G, Iaffaldano, P, Lucchese, G, Dattola, V, Buccafusca, M, Sola, P, Simone, Am, Barreca, F, Patti, F, Laisa, P, Cavalla, P, Masera, S, Tavazzi, E, Galgani, S, Tedeschi, G, Sacco, R, Provinciali, L, Maura, D, Lus, G, Alfieri, G, Ticca, A, Piras, Ml, Maimone, D, Bianca, M, Iudice, A, Giro, Me, Galeotti, M, Florio, C, Spitalieri, P, La Mantia, L, Motti, L, Rottoli, Mr, Granella, F, Solaro, C, Scarpini, E, Servillo, G, Cavaletti, G., Martinelli, V., Cocco, E., Capra, R., Salemi, G., Gallo, P., Capobianco, M., Pesci, I., Ghezzi, A., Pozzilli, C., Lugaresi, A., Bellantonio, P., Amato, M. P., Grimaldi, L. M., Trojano, M., Mancardi, G. L., Bergamaschi, R., Gasperini, C., Rodegher, M., Straffi, L., Ponzio, M., Comi, G., Radaelli, M., Esposito, F., Moiola, L., Colombo, B., Rossi, P., Marrosu, M. G., Frau, J., Lorefice, L., Coghe, G., Savettieri, G., Ragonese, P., Cusimano, V., Perini, P., Rinaldi, F., Vidali, A., Bertolotto, A., Malucchi, S., Di Sapio, A., Montanari, E., Guareschi, A., Rizzo, A., Zaffaroni, M., Baldini, S., De Rossi, N., Cordioli, C., Rasia, S., Salvetti, M., Buttinelli, C., Ausili Cefaro, L., De Luca, Giovanna, Tommaso, D., Farina, D., Fantozzi, R., Ruggieri, S., Hakiki, B., Zipoli, V., Portaccio, E., Bartolozzi, M. L., Scandellari, C., Stecchi, S., Marchello, L. P., Palmeri, B., Vitello, G., Iaffaldano, P., Lucchese, G., Dattola, V., Buccafusca, M., Sola, P., Simone, A. M., Barreca, F., Patti, F., Laisa, P., Cavalla, P., Masera, S., Tavazzi, E., Galgani, S., Tedeschi, G., Sacco, R., Provinciali, L., Maura, D., Lus, G., Alfieri, G., Ticca, A., Piras, M. L., Maimone, D., Bianca, M., Iudice, A., Giro, M. E., Galeotti, M., Florio, C., Spitalieri, P., La Mantia, L., Motti, L., Rottoli, M. R., Granella, F., Solaro, C., Scarpini, E., Servillo, G., Cavaletti, G., Radaelli, M, Esposito, F, Moiola, L, Colombo, B, Rossi, P, Marrosu, MG, Frau, J, Lorefice, L, Coghe, G, Savettieri, G, Ragonese, P, Cusimano, V, Perini, P, Rinaldi, F, Vidali, A, Bertolotto, A, Malucchi, S, Di Sapio, A, Montanari, E, Guareschi, A, Rizzo, A, Zaffaroni, M, Baldini, S, De Rossi, N, Cordioli, C, Rasia, S, Salvetti, M, Buttinelli, C, Ausili Cefaro, L, De Luca, G, Tommaso, D, Farina, D, Fantozzi, R, Ruggieri, S, Amato, MP, Hakiki, B, Zipoli, V, Portaccio, E, Bartolozzi, ML, Scandellari, C, Stecchi, S, Marchello, LP, Palmeri, B, Vitello, G, Iaffaldano, P, Lucchese G, Dattola V, Buccafusca M, Sola, P, Simone, AM, Barreca, F, Patti, F, Laisa, P, Cavalla, P, Masera, S, Tavazzi, E, Galgani, S, Tedeschi, G, Sacco, R, Provinciali, L, Maura, D, Lus, G, Alfieri, G, Ticca, A, Piras, ML, Maimone, D, Bianca, M, Iudice, A, Giro, ME, Galeotti, M, Florio, C, Spitalieri, P, La Mantia, L, Motti, L, Rottoli, MR, Granella, F, Solaro, C, Scarpini, E, Servillo, G, Cavalletti, G, Salemi, G, Martinelli, V, Cocco, E, Capra, R, Gallo, P, Capobianco, M, Pesci, I, Ghezzi, A, Pozzilli, C, Lugaresi, A, Bellantonio, P, Amato, M, Grimaldi, L, Trojano, M, Mancardi, G, Bergamaschi, R, Gasperini, C, Rodegher, M, Straffi, L, Ponzio, M, Comi, G, Cavaletti, G, and DIPARTIMENTO DI SCIENZE BIOMEDICHE E NEUROMOTORIE

Subjects
Male, medicine.medical_specialty, Myeloid, mitoxantrone, acute myelocytic leukemia, multiple sclerosis, Population, Statistics, Nonparametric, Follow-Up Studie, Arts and Humanities (miscellaneous), Retrospective Studie, Internal medicine, Multiple Sclerosi, medicine, Humans, multiple sclerosis, leukemia, mitoxantrone, Prospective cohort study, education, Retrospective Studies, Aged, Analgesics, education.field_of_study, Mitoxantrone, Cumulative dose, business.industry, Multiple sclerosis, Incidence (epidemiology), leukemia, Myeloid leukemia, Retrospective cohort study, medicine.disease, Confidence interval, Surgery, Leukemia, Leukemia, Myeloid, Acute, medicine.anatomical_structure, Italy, Cohort, Settore MED/26 - Neurologia, Analgesic, Female, Neurology (clinical), business, Follow-Up Studies, medicine.drug, Human
Abstract

none 25 no Abstract OBJECTIVES: To evaluate the incidence and dose-dependency of mitoxantrone (MTX)-associated acute myelocytic leukemia (AML) in the network of Italian multiple sclerosis (MS) clinics. METHODS: We performed a multicenter retrospective cohort study of patients treated with MTX in MS centers under the Italian national health care system between 1998 and 2008. Demographic, disease, treatment, and follow-up information were collected using hospital records. RESULTS: Data were available for 3,220 patients (63% women) from 40 Italian centers. Follow-up (mean ± SD) was 49 ± 29 months (range 12-140 months). We observed 30 cases of AML (incidence 0.93% [95% confidence interval 0.60%-1.26%]). The mean cumulative dose was higher in patients with AML (78 vs 65 mg/m(2), p = 0.028). The median interval from the start of therapy to AML diagnosis was longer than expected at 33 months (range 13-84 months); 8 patients (27%) developed AML 4 years or more after the first MTX infusion. The rate of mortality associated with AML was 37%. CONCLUSIONS: This higher than expected risk of AML and related mortality requires that treatment decisions must be made jointly between clinicians and patients who understand their prognosis, treatment options, and treatment-related risks. The now large exposed MS population must be monitored for hematologic abnormalities for at least 6 years from the end of therapy, to ensure the rapid actions needed for early diagnosis and treatment of AML. none Martinelli V; Cocco E; Capra R; Salemi G; Gallo P; Capobianco M; Pesci I; Ghezzi A; Pozzilli C; Lugaresi A; Bellantonio P; Amato MP; Grimaldi LM; Trojano M; Mancardi GL; Bergamaschi R; Gasperini C; Rodegher M; Straffi L; Ponzio M; Comi G; For The Italian Mitoxantrone Group; De Luca G; Di Tommaso V; Farina D Martinelli V; Cocco E; Capra R; Salemi G; Gallo P; Capobianco M; Pesci I; Ghezzi A; Pozzilli C; Lugaresi A; Bellantonio P; Amato MP; Grimaldi LM; Trojano M; Mancardi GL; Bergamaschi R; Gasperini C; Rodegher M; Straffi L; Ponzio M; Comi G; For The Italian Mitoxantrone Group; De Luca G; Di Tommaso V; Farina D

Published
2011

110. Sensitivity and predictive role of OCT and VEP in multiple sclerosis

Author

Di Maggio, G., Santangelo, R., Guerrieri, S., Ferrari, L., Vitali, F., Medaglini, S., Rodegher, M., Colombo, B., Moiola, L., Del Carro, U., Martinelli, V., Comi, G., Leocani, L., Di Maggio, G., Santangelo, R., Guerrieri, S., Ferrari, L., Vitali, F., Medaglini, S., Rodegher, M., Colombo, B., Moiola, L., Del Carro, U., Martinelli, V., Comi, G., and Leocani, L.

Published
2015

111. Medium and long term efficacy of nabiximols for the treatment of multiple sclerosis related spasticity: an Italian monocentric study

Author

Ferre, L., Nuara, A., Pavan, G., Radaelli, M., Moiola, L., Rodegher, M., Colombo, B., Sarmiento, I.J.K., Martinelli, V., Comi, G., Boneschi, F.M., Esposito, F., LEOCANI , ANNUNZIATA MARIA LETIZIA, Ferre, L., Nuara, A., Pavan, G., Radaelli, M., Moiola, L., Rodegher, M., Colombo, B., Sarmiento, I. J. K., Martinelli, V., Leocani, ANNUNZIATA MARIA LETIZIA, Comi, G., Boneschi, F. M., and Esposito, F.

Published
2015

112. Impact of MS genetic loci on familial aggregation, clinical phenotype, and disease prediction

Author

Esposito F, Guaschino C, Sorosina M, Clarelli F, Ferre' L, Mascia E, Santoro S, Pagnesi M, Radaelli M, Colombo B, Moiola L, Rodegher M, Stupka E, Martinelli V, Martinelli Boneschi F., COMI , GIANCARLO, Esposito, F, Guaschino, C, Sorosina, M, Clarelli, F, Ferre', L, Mascia, E, Santoro, S, Pagnesi, M, Radaelli, M, Colombo, B, Moiola, L, Rodegher, M, Stupka, E, Martinelli, V, Comi, Giancarlo, and Martinelli Boneschi, F.

Published
2015

113. Erratum to: Early (≤1-h) vs. late (>1-h) administration of frovatriptan plus dexketoprofen combination vs. frovatriptan monotherapy in the acute treatment of migraine attacks with or without aura: a post hoc analysis of a double-blind, randomized, parallel group study

Author

Allais G, Bussone G, Tullo V, Cortelli P, Valguarnera F, Barbanti P, Sette G, Frediani F, D'Arrigo G, d'Onofrio F, Curone M, Colombo B, Omboni S, Benedetto C., COMI , GIANCARLO, Allais, G, Bussone, G, Tullo, V, Cortelli, P, Valguarnera, F, Barbanti, P, Sette, G, Frediani, F, D'Arrigo, G, D'Onofrio, F, Comi, Giancarlo, Curone, M, Colombo, B, Omboni, S, and Benedetto, C.

Published
2015

115. The Multiple Sclerosis Knowledge Questionnaire: a self-administered instrument for recently diagnosed patients

Author

Giordano, A, Uccelli, Mm, Pucci, E, Martinelli, V, Borreani, C, Lugaresi, A, Trojano, M, Granella, F, Confalonieri, P, Radice, D, Solari, A, D'Alessandro, R, Heesen, C, Mancardi, Gl, Milanese, C, Galimberti, S, Calabrese, D, Ferrari, G, Mattarozzi, K, Antozzi, C, Lauria, G, La Mantia, L, Pedotti, R, Mantegazza, R, Maggi, L, Colombo, B, Esposito, F, Moiola, L, Rodegher, M, Radaelli, M, Immovilli, P, Dalla Bella, E, De Luca, G, Mattoscio, M, Di Ioia, M, Pace, M, Travaglini, D, Maruotti, V, Farina, D, Zimatore, G, Plasmati, I, Tortorella, C., Giordano A., Uccelli M.M., Pucci E., Martinelli V., Borreani C., Lugaresi A., Trojano M., Granella F., Confalonieri P., Radice D., Solari A., D'Alessandro R., Heesen C., Mancardi G.L., Milanese C., Galimberti S., Calabrese D., Ferrari G., Mattarozzi K., Antozzi C., Lauria G., La Mantia L., Pedotti R., Mantegazza R., Maggi L., Colombo B., Esposito F., Moiola L., Rodegher M., Radaelli M., Immovilli P., Dalla Bella E., De Luca G., Mattoscio M., Di Ioia M., Pace M., Travaglini D., Maruotti V., Farina D., Zimatore G., Plasmati I., Tortorella C., (SIMS-Trial group)., Giordano, A., Uccelli, M. M., Pucci, E., Martinelli, V., Borreani, C., Lugaresi, A., Trojano, M., Granella, F., Confalonieri, P., Radice, D., Solari, A., D'Alessandro, R., Heesen, C., Mancardi, G. L., Milanese, C., Galimberti, S., Calabrese, D., Ferrari, G., Mattarozzi, K., Antozzi, C., Lauria, G., La Mantia, L., Pedotti, R., Mantegazza, R., Maggi, L., Colombo, B., Esposito, F., Moiola, L., Rodegher, M., Radaelli, M., Immovilli, P., Dalla Bella, E., De Luca, G., Mattoscio, M., Di Ioia, M., Pace, M., Travaglini, D., Maruotti, V., Farina, D., Zimatore, G., Plasmati, I., and Tortorella, C.

Subjects
Questionnaires, Male, law.invention, Disability Evaluation, Randomized controlled trial, Informed consent, law, Surveys and Questionnaires, Multiple Sclerosi, Content validity, Surveys and Questionnaire, Medicine, Young adult, Patient-reported outcome, Informed Consent, Psychiatric Status Rating Scale, Middle Aged, Newly diagnosed, Test (assessment), Knowledge, Neurology, Italy, drug therapy/psychology, Female, Human, Adult, Employment, medicine.medical_specialty, Multiple Sclerosis, Logistic Model, Adolescent, multiple sclerosis, questionnaire, MEDLINE, Reproducibility of Result, Education, Young Adult, Patient Education as Topic, Adolescent, Adult, Disability Evaluation, Education, Employment, Female, Humans, Informed Consent, Italy, Logistic Models, Male, Middle Aged, Multiple Sclerosis, drug therapy/psychology, Patient Education as Topic, Psychiatric Status Rating Scales, Questionnaires, Reproducibility of Results, Young Adult, Humans, Psychiatric Status Rating Scales, Questionnaire, business.industry, Construct validity, Reproducibility of Results, Surgery, Clinical trial, Logistic Models, Measurement development, Physical therapy, Neurology (clinical), business
Abstract

There are few studies on patient knowledge in multiple sclerosis (MS), and only two published questionnaires. The objective of this article was to develop and validate the MS Knowledge Questionnaire (MSKQ), a self-assessed instrument for newly diagnosed MS patients. Thirty multiple-choice statements, conceived to test MS knowledge, were produced by a multidisciplinary panel and pre-tested on three MS patients, resulting in an intermediate 26-item version. This was tested on 54 MS patients for internal consistency, content and construct validity (validation sample I). The final (25-item) MSKQ was a primary outcome measure in the SIMS-Trial on an information aid to newly diagnosed MS patients. Postal responses of SIMS-Trial participants to the MSKQ a month after intervention (validation sample II) were analysed. Median MSKQ scores in validation samples I and II were, respectively, 18 (range 9—23) and 17 (range 3—24). Acceptability, internal consistency (Kuder—Richardson-20 formula 0.76) and content validity were good. Educational attainment and receiving the information aid were the main independent predictors of MS knowledge. Other predictors were female sex (positive association) and disease duration (negative association). In conclusion, the MSKQ has good clinimetric properties and is sensitive to an educational intervention. We propose the MSKQ as a brief instrument for clinical practice and research.

Published
2009

119. Familial clustering in Italian progressive-onset and bout-onset multiple sclerosis

Author

Guaschino C, Esposito F, Liberatore G, Colombo B, Annovazzi P, D'Amico E, Cavalla P, Capello E, Capra R, Galimberti D, Tedeschi G, Grimaldi L, PROGRESSO Group, COMI , GIANCARLO, Guaschino, C, Esposito, F, Liberatore, G, Colombo, B, Annovazzi, P, D'Amico, E, Cavalla, P, Capello, E, Capra, R, Galimberti, D, Tedeschi, G, Grimaldi, L, Progresso, Group, and Comi, Giancarlo

Published
2014

120. Experience of an information aid for newly diagnosed multiple sclerosis patients: A qualitative study on the SIMS-Trial

Author

Borreani, Claudia, Giordano, Andrea, Falautano, Monica, Lugaresi, Alessandra, Martinelli, Vittorio, Granella, Franco, Tortorella, Carla, Plasmati, Imma, Radaelli, Marta, Farina, Deborah, Dalla Bella, Eleonora, Bianchi, Elisabetta, Acquarone, Nicola, Miccinesi, Guido, Solari, Alessandra, D'Alessandro, R., Pucci, E., Uccelli, M. M., Trojano, M., Heesen, C., Mancardi, G. L., Milanese, C., Calabrese, D., Ferrari, G., Mattarozzi, K., Confalonieri, P., Antozzi, C., Maggi, L., Mantegazza, R., Martinelli, V., Colombo, B., Esposito, F., Moiola, L., Rodegher, M., Immovilli, P., De Luca, Giovanna, Di Tommaso, V., Di Ioia, M., Travaglini, D., Pietrolongo, E., Zimatore, G., Borreani, Claudia, Giordano, Andrea, Falautano, Monica, Lugaresi, Alessandra, Martinelli, Vittorio, Granella, Franco, Tortorella, Carla, Plasmati, Imma, Radaelli, Marta, Farina, Deborah, Dalla Bella, Eleonora, Bianchi, Elisabetta, Acquarone, Nicola, Miccinesi, Guido, Solari, Alessandra, D'Alessandro, R., Pucci, E., Uccelli, M. M., Trojano, M., Heesen, C., Mancardi, G. L., Milanese, C., Calabrese, D., Ferrari, G., Mattarozzi, K., Confalonieri, P., Antozzi, C., Maggi, L., Mantegazza, R., Martinelli, V., Colombo, B., Esposito, F., Moiola, L., Rodegher, M., Immovilli, P., De Luca, Giovanna, Di Tommaso, V., Di Ioia, M., Travaglini, D., Pietrolongo, E., and Zimatore, G.

Subjects
Adult, Male, Clinical Trials as Topic, Patient, Time Factor, Public Health, Environmental and Occupational Health, Middle Aged, Diagnosis communication, Complex intervention, Patient Education as Topic, Physician, Multiple Sclerosi, Female, Qualitative study, Shared decision making, Qualitative Research, Human
Abstract

Background The SIMS-Trial (ISRCTN81072971) proved the effectiveness, in terms of patient's knowledge and care satisfaction, of an add-on information aid (personal interview with a physician using a navigable CD and take-home booklet) in 120 newly diagnosed patients with multiple sclerosis (MS) from five Italian centres. Objective To scrutinize the experience of SIMS-Trial participants in order to gain better understanding of the effectiveness of the information aid and its components. Design We performed (i) nine individual semi-structured interviews with a purposeful sample of SIMS-Trial patients who received the information aid, (ii) focus group meeting (FGM) with the physicians who conducted the personal interview, and (iii) FGM with patients' caring neurologists. Results Patients' experience with the information aid was positive as it enhanced their understanding of their disease, being viewed as a guided tour of their medical condition. The physicians who conducted the personal interviews were also positive in their overall evaluation but noted an initial difficulty in using the CD. The caring neurologists had limited direct experience of the aid, and their views were confined to utility of the information aid in general. All participants considered the combination of personal interview, CD navigation and take-home booklet essential, but urged a more flexible scheduling of the personal interview. It also emerged that some content required revision and that the aid was unsuitable for patients with primary progressive MS. Conclusions The results of the study further support the value of the aid and also provide important indications for improving it and refining indications for use. © 2011 John Wiley & Sons Ltd.

Published
2014

123. Mediterranean Symposium of rheumatology: Naples, 14–15 June, 1984

Author

Schiavetti, L., Galeazzi, M., Purpura, M., Pras, M., Zemer, D., Cabili, S., Ciocci, A., Colombo, B., Tosi, S., Govoni, E., Genacchi, G., Carcassi, U., Mela, Q., Bonomo, L., Aiuti, F., D'Amelio, R., Puigdollers-Colas, J. M., Roca-Rossellini, N., Permanyer-Barrier, J., Rovellat, M. A. Puigdollers, Georgiadis, A. E., Yazici, H., Tuzun, Y., Yurdakul, S., Pazarli, H., Ozyazgan, Y., Ozdogan, H., Serdarogu, S., Ersanli, M., Ulku, B., Muftuoglu, A., Dilsen, N., Konice, M., Aral, O., Giordano, M., Cotticelli, L., Migliaresi, S., Picillo, U., Tirri, G., Hamza, M., Ciompi, M. L., Fosella, P. V., Ammannati, P., Gremignal, G., Olivieri, I., Tassoni, S., Pecori, F., Gamici, M., Porciatt, A., Fantini, F., Valenti, F., Marin, F., Mercuriali, F., Figueirinhas, J., Silva, V., Tanakol, R., Pecar, J., Daneo, V., Modena, V., Maiocco, I., Bosio, C., De Filipi, P. G., Drosos, A. A., Moutsopoulos, H. M., Oriente, P., Scarpa, R., Pucino, A., Biondi-Oriente, C., Jacquot, P., Blanc, M., Giordano, D., Pennec, Y., Youinou, P., Mottier, D., Jouquan, J., Gentric, A., Ferec, C., Le Menn, G., Ambamelli, U., Kontomerkos, A., Karagiannidis, N., Georgiadis, A., Dantis, P., Dilsen, G., Rovetta, G., Cervini, C., Hadidi, T., Valentini, G., Chianese, U., Gualdieri, L., Maniera, A., Tirri, R., La Palombara, F., Mavridis, A. K., Serratrice, G., Schiano, A., Desnuelles, C., Pouget, J., Zoppini, A., Taccari, E., Teddori, S., Roux, H., Antipoff, G. M., Paris, D., Thivolet, J., Hermier, C., Fabiano, F., Bevilacqua, M., Ramonda, R., Lazzarin, P., Ostuni, P. A., Todesco, S., Contantopoulos, S. H., Capelli, L., Vatti, M., Fichera, G., Sany, J., Combes, B., Cosso, B., Bonneaux, M., Andary, M., Clot, J., Consoli, G., Di Mattteo, L., Wirth, W., Lonauer, G., Demptroeder, F., Sinigaglia, L., Guidi, G., Ranza, R., Marchesoni, A., Abdelkafi, M. M., Medeb, T., Kassab, M. T., Cammoun, M., Jaafoura, H., Hamza, R., Ben Lamine, B., Traballi, G., Aletti, A., Imbimbo, B., Canesi, B. A., Cutolo, M., Accardo, S., Castellani, P., Borsi, L., Cimmino, M., Zardi, L., Scagliusi, P., Fasiello, V., De Lucia, M., Loizzi, P., Pipitone, V., Ribatti, D., Contino, R., Di Pietro, F., Scarano, R., Tursi, A., Le Goff, P., Coutois, B., Lydyard, P. M., Le Poivre, B., Brousse, A., Rossi, A., Bini, M., Arcidiacono, R., Canesi, B., Casadei, G., Barberis, M., Buffrini, G. Rovetta, Nicolini, F., Zakraoui, L., Daly, L., Daouissi, N., Haddad, S., La Montagna, G., Gallo, M., Squame, G., Giordano, A., Quattrocchi, G., Molica, A., Grasso, E., Lagana, A., Sirna, R., Olivieri, J., Rizzo, G., Porciatti, A., Italia, A., Capone, M., Zorbin, L., Cherie-Ligniere, G., Marconi, A., Colombo, B., Coche, P., Riccio, A., De Marco, F., Farinaro, C., Prantera, T., Ferri, S., Villeco, A. S., Giacovazzo, M., Romiti, A., Martelletti, P., Gallo, M. F., Casale, R., Sessarego, P., Kokodoko, A., Dato, G., Cimmino, M. A., Bianchi, G., Mancinelli, S., Marazzi, M. C., Palombi, L., Concerva, P., Fiore, L., Biaccarini, V., Pana, A., Venegoni, C., Chevallard, M., Carrabba, M., Paresce, E., Anelini, M., Viara, M., Galcagno, L., Mercier, P., Fasciolo, D., Maglio, M. L., Carrara, P., Seriolo, B., Ferretti, A., Giglio, A., Vinci, M., Raciti, T., Gatto, A., DiStefano, F., Carcassi, A., Boschi, S., Campagna, S., Quattrohi, G., Musolino, C., Aliquo, E., Di Stefano, F., Crovato, F., Nazzari, G., Herne, J. P., Cledes, J., Guillodo, M. P., Le Guy, P., Bourbigot, B., Riccio, R., Farinaro, L., Scognamiglio, A., Lanteri, L., Percivalle, A., Maccagolo, P., Soave, G., Samanta, E., Zorzin, L., and Biagiotti, T.

Published
1985
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124. Ankle-Brachial Index and cardiovascular events in atrial fibrillation The ARAPACIS Study

Author

Violi, F., Davi, G., Proietti, M., Pastori, D., Hiatt, W. R., Corazza, G. R., Perticone, F., Pignatelli, P., Farcomeni, A., Vestri, A. R., Lip, G. Y. H., Basili, S, ARAPACIS (Atrial Fibrillation Registry for Ankle-Brachial Index Prevalence Assessment-Collaborative Italian Study) STUDY Investigators. Alessandri C. (Dipartimento di Scienze e Biotecnologie Medico-Chirurgiche, Sapienza-Università di Roma), Serviddio G. (Department of Medical and Surgical Sciences, University of Foggia), (UOC Medicina Generale, Fascetti S., USL 12 Viareggio, Toscana), (UOC Medicina Interna I, Palange P., Dipartimento di Sanità Pubblica, e Malattie Infettive, Sapienza-Università di Roma), Greco, E., (Medicina 3, Bruno G., Department of Medical Sciences, Città della Salute e della Scienza, A. O., University of Turin), Averna, M., (Dipartimento Biomedico di Medicina Interna e Specialistica, Giammanco A., Università di Palermo), Sposito P. (Azienda Ospedaliera Ospedali Riuniti Papardo Piemonte, Messina), De Cristofaro, R., (Istituto di Medicina Interna e Geriatria, De Gennaro L., Centro Emostasi, e Trombosi, Gemelli, Policlinico A., Roma), Carulli, L., (UO di Medicina a Indirizzo Nutrizionistico e Metabolico, Pellegrini E., Università degli Studi di Modena e Reggio Emilia), Dipartimento Integrato di Medicina Endocrinologia Metabolismo e Geriatria., Cominacini, L., Mozzini, C., (Dipartimento di Medicina, Pasini A. F., Sezione di Medicina Interna, D, Università di Verona), Sprovieri, M., (UOC Medicina d'Urgenza e PS, Spagnuolo V., Stabilimento Ospedaliero dell'Annunziata, Cosenza), (UOC Medicina Interna per l'Urgenza, Cerqua G., S Giovanni Addolorata, Ao, Cerasola G., Mulé G. (Università degli Studi di Palermo), Barbagallo, M., Lo Sciuto, S., (UOC di Geriatria e Lungodegenza, Monteverde A., Azienda Ospedaliera Universitaria Policlinico, Aoup, Palermo), Saitta, A., (UOC Medicina Interna, Lo Gullo A., Università di Messina), Malatino, L., Cilia, C., Terranova, V., (Clinica Medica, Pisano M., Ospedale, Cannizzaro, Università degli Studi di Catania), Pinto, A., Di Raimondo, D., Tuttolomondo, A., (Internal Medicine and Cardio-Angiology Ward, Conigliaro R., Department of Biomedicine and Internal Medicine, University of Palermo), Signorelli S. (Dipartimento di Medicina Interna e Patologia, Università degli Studi di Catania), De Palma, D., Galderisi, M., (Dipartimento di Medicina Clinica e Sperimentale, Cudemo G., AUP Federico II di Napoli), Galletti, F., (Dipartimento di Medicina Clinica e Chirurgia, Fazio V., Università di Napoli Federico II), De Luca, N., (Centro Ipertensione, Meccariello A., AUO Federico II, Napoli), Caputo, D., (UO Medicina Interna, De Donato M. T., Azienda Ospedaliera Universitaria San Giovanni di Dio, e Ruggi D'Aragona, Salerno), Iannuzi, A., (Divisione di Medicina Interna, Bresciani A., Cardarelli, Osp. A., (V Divisione Medicina Interna ed Immunoallergologia, Giunta R., Policlinico, Sun, Utili, R., (Medicina Infettivologica e dei Trapianti, Iorio V., Seconda Università di Napoli, AORN dei Colli-Monaldi), Adinolfi, L. E., Sellitto, A., (Medicina Interna, Iuliano N., Ospedale di Marcianise), Bellis, P., (UOC Medicina Interna e di Urgenza e Pronto Soccorso, Tirelli P., del Loreto Nuovo, P. O. S. M., Loreto, Mare), (Clinica Medica 5, Sacerdoti D., Dipartimento di Medicina DIMED, Università degli Studi di Padova), (UO Medicina Interna Arezzo, Vanni D., Ospedale San Donato, Azienda USL, 8 Arezzo), Iuliano, L., Ciacciarelli, M., (Department of Medico-Surgical Sciences and Biotechnology, Pacelli A., Vascular Biology, Mass Spectrometry Lab, Sapienza-University of Rome), Palazzuoli A. (UOS Malattie Cardiovascolari Dipartimento di Scienze Mediche Chirurgiche e Neuroscienze, Università di Siena), Cacciafesta, M., Gueli, N., Lo Iacono, C., Brusco, S., (UOC di Medicina Geriatrica e Riabilitazione, Verrusio W., Sapienza-Università di Roma, Nobili, L., Tarquinio, N., (UO Medicina 'SS Benvenuto e Rocco', Pellegrini F., Dipartimento di Medicina Interna, Asur, Marche, Area Vasta, n. 2., ex ZT 7), (UOS Breve Osservazione, Vincentelli G. M., Calibita 'Fatebenefratelli' Isola Tiberina, Ospedale S. G., Ravallese, F., (UOC Medicina Interna, Santini C., Ospedale, Vannini, Letizia, C., Petramala, L., (UOD Ipertensione Secondaria, Zinnamosca L., Dipartimento di Medicina Interna, e Specialità Mediche, Minisola, S., Cilli, M., Savoriti, C., (UOC Medicina Interna F e Malattie Metaboliche dell'osso- Sapienza-Università di Roma), Colangelo L., Falaschi, P., Martocchia, A., (UO Geriatria, Pastore F., Andrea, Azienda Ospedaliera S., Facoltà diMedicina, e Psicologia, Bertazzoni, G., (UOC Medicina d’Urgenza, Attalla El Halabieh E., Dipartimento di Emergenza ed Accettazione, Paradiso, M., Lizzi, E. M., (Ospedale San Giovanni Battista, Timmi S., Ordine di Malta, (Medicina Interna II, Battisti P., Ospedale San Giovanni-Addolorata, (UOC Medicina Interna, Cerci S., Ospedali Riuniti Frascati, Marino), (UOC Cardiologia-UTIC, Ciavolella M., Ospedale di Frascati, (Centro dell’Ipertensione Arteriosa e delle Malattie Metaboliche e Renali, Di Veroli C., Casa di Cura 'San Domenico', Malci, F., (UOC di Medicina Interna, De Ciocchis A., Ospedale, ASL Roma, G, Subiaco), Abate, D. (Az., Castellino, P., Zanoli, L., (UOC Medicina Interna, Fidone F., Dipartimento di Medicina Clinica, e Sperimentale, Mannarino, E., Pasqualini, L., (Medicina Interna, Oliverio G., Università degli Studi di Perugia), Pende, A., (Clinica di Medicina Interna 1, Artom N., Università di Genova, San Martino - IST), IRCCS Az. Osp. Univ., Ricchio, R., (UOC Geriatria, Fimognari F. L., Azienda Ospedaliera di Cosenza, Alletto, M., (Unità Operativa di Medicina, Messina S., Elia, Ospedale S., Caltanissetta), Sesti, G., Arturi, F., Fiorentino, T. V., (Università degli Studi, Pedace E., UOC Medicina Interna, Policlinico Universitario 'Mater Domini'), Scarpino, P. E., Carullo, G., Maio, R., (Cattedra di Medicina Interna, Sciacqua A., UO Malattie Cardiovascolari, Campus Universitario di Germaneto, Università Magna Graecia di Catanzaro), Frugiuele, P., (UOC Medicina Interna e Reumatologia, Spagnuolo V., Stabilimento Ospedaliero Annunziata, Azienda Ospedaliera Cosenza), (UO Lungodegenza, Battaglia G., Serra San Bruno, S. O., ASP Vibo Valentia), Atzori, S., (Clinica Medica, Delitala G., Aou, Sassari), Angelucci, E., (UOC di Clinica Medica, Sestili S., PO Clinicizzato di Chieti), Traisci, G., (UOC Medicina Interna 2, De Feudis L., PO di Pescara), Di Michele, D., (UOC Medicina Interna, Fava A., Asl, Teramo), Balsano, C., (Dipartimento di Medicina Interna e Sanità Pubblica, De Ciantis P., Università, dell'Aquila), Desideri, G., (UOC Geriatria e Lungodegenza Geriatrica, Camerota A., Dipartimento Medico ORM, Avezzano), Po, Mezzetti M. (UOC Medicina Interna Ospedale del Casentino-Direttore Dr. Emilio Santoro, AUSL8 Arezzo), Gresele, P., Vedovati, C., (Dipartimento di Medicina Interna, Fierro T., Sezione di Medicina Interna, e Cardiovascolare, Università di Perugia), (Centro Aterosclerosi, Puccetti L., Trombosi, e Coagulopatie, Università degli Studi di Siena, Azienda Ospedaliero-Universitaria Senese), Bertolotti, M., (UO Geriatria, Mussi C., Boddi, M., Savino, A., Contri, S., (Dipartimento di Medicina Sperimentale e Clinica, Degl'Innocenti G., Università degli Studi di Firenze), Saller, A., (Clinica Medica 1, Fabris F., Medicina Interna CLOPD, Departement of Medicine DIMED, University of Padova), Pesavento, R., Filippi, L., (Dipartimento di Scienze Cardiologiche, Vedovetto V., Toraciche, e Vascolari, Clinica Medica, 2, Azienda Ospedaliera-Università di Padova), (Clinica Medica IV, Puato M., Dipartimento di Medicina, Azienda Ospedaliera Universitaria Padova, Padova), Fabris, F., (UOA Medicina, Treleani M., Policlinico, Universitario, De Luca, E., De Zaiacomo, F., (Clinica Geriatrica, Giantin V., Università di Padova), (Medicina Interna 1, Semplicini A., Giovanni e Paolo, Ospedale SS., Venezia), Minuz, P., (Sezione di Medicina Interna C, Romano S., Università di Verona, Aoui, Verona), Fantin, F., (Dipartimento di Medicina, Manica A., Sezione di Geriatria, Stockner, I., Pattis, P., Wiedermann, Gutmann B. (Divisione di Medicina Interna-Direttore Prof. J., Ospedale Centrale di Bolzano), Catena, C., Colussi, G., (Clinica Medica, Sechi L. A., Dipartimento di Scienze Mediche Sperimentali, e Cliniche, Università di Udine, Italy), Annoni, G., Bruni, A. A., (Clinica Geriatrica, Castagna A., Università degli Studi di Milano-Bicocca, Dipartimento di Medicina, e Chirurgia, AO San Gerardo, Monza), (Medicina Interna 1, Spinelli D., Dipartimento di Scienze Cliniche, e di Comunità, Fondazione, Irccs, Università di Milano), (Clinica Medica I, Miceli E., Reparto, 11, IRCCS Policlinico San Matteo di Pavia), Schinco, G., (UOC Geriatria, Spreafico S., Fondazione IRCCS Cà Granda, Ospedale Maggiore Policlinico), (UOC Medicina Interna, Secchi B., Ospedale, Bassini, Milano), Vanoli, M., Casella, G., (SC Medicina Interna, Pulixi E. A., Azienda Ospedaliera della Provincia di Lecco, Ospedale di Merate, Lecco), Sansone, L., (UOC Medicina, Serra M. G., Panico', Azienda Ospedaliera 'Cardinale G., Tricase, (Lecce), Longo, S., (UOC Medicina Interna, Antonaci S., Azienda Ospedaliera Policlinico, Bari), Belfiore, A., Frualdo, M., Palasciano, G., Murri'- Bari), Ricci L. (Clinica Medica 'A., (Struttura Complessa di Medicina Interna, Ventrella F., Cerignola, Asl, Foggia), (UOC Medicina Interna, Bianco C., Tropea), Santovito, D., (Centro di Eccellenza Europeo e di Riferimento Regionale per l'Aterosclerosi, Cipollone F., l'Ipertensione Arteriosa, e le Dislipidemie, Università, Chieti), Nicolai, S., (UO Medicina Interna, Salvati F., Ospedale di Ortona, ASL 02 Abruzzo), Rini, G. B., (UOC Medicina Interna ed Ipertensione, Scozzari F., Dipartimento Biomedico di Medicina Interna, e Specialistica, Giaccone' di Palermo), Policlinico 'P., Muiesan, M. L., Salvetti, M., (Dipartimento di Scienze Cliniche e Sperimentali, Bazza A., Università di Brescia, 2° Medicina Generale Spedali Civili), Picardi, A., Vespasiani-Gentilucci, U., (Medicina Interna e Epatologia, De Vincentis A., Università Campus Bio-Medico, Cosio, P., (Medicina Interna 1, Terzolo M., Dipartimento di Scienze Cliniche, e Biologiche, AOU San Luigi Gonzaga, Università di Torino), Madaffari, B., (UO Medicina Interna, Parasporo B., Azienda Ospedaliera Bianchi Melacrino Morelli, Reggio, Calabria), Fenoglio, L., Bracco, C., (SC Medicina Interna, Melchio R., Croce e Carle, AO S., Cuneo), Gentili, T., (Medicina Generale - Settore Subintensivo, Salvi A., Azienda Ospedaliero- Universitaria, Ancona), (Medicina Generale - Settore Ordinario, Nitti C., Azienda, Ospedaliero-Universitaria, Gabrielli, A., (Clinica Medica, Martino G. P., Capucci, A., Brambatti, M., (Clinica di Cardiologia, Sparagna A., Ospedale, Torrette, (UO Medicina Generale IV, Tirotta D., Ospedale, Cervesi, Cattolica), Andreozzi, P., Ettorre, E., Viscogliosi, G., Servello, A., (Area Geriatria, Musumeci M., DAI Medicina Interna, Rossi Fanelli, F., Delfino, M., (UOC Medicina Interna H, Giorgi A., Sapienza- Università di Roma), Glorioso, N., Melis, G., Marras, G., (Ambulatorio Ipertensione Arteriosa e Patologie Correlate, Matta M., (UOC Medicina Interna, Sacco A., PO Madonna delle Grazie, Matera), Stellitano, E., (UO Medicina, Scordo A., PO 'Tiberio Evoli', Melito Porto Salvo), Russo, F., (UOC Medicina Generale di Rogliano, Caruso A. A., AO di Cosenza), Porreca, E., (UO Medicina Interna e Geriatria, Tana M., D'Annunzio, Università G., Chieti-Pescara), Ferri, C., (Divisione di Medicina Interna e Nefrologia - Ospedale San Salvatore, Cheli P., Dipartimento, Mesva, (Clinica Medica 'Murri', Portincasa P., Dipartimento di Scienze Mediche, e Oncologia Umana, Università degli Studi di Bari), Muscianisi G. (ASP Reggio Calabria, Saline Joniche), Giordani, S., (Dipartimento di Scienze Mediche e Chirurgiche, Stanghellini V., Università degli Studi di Bologna), Sabbà C. (UOC Geriatria e Centro di assistenza e ricerca sovraziendale per le malattie rare, Bari), Mancuso, G., Bartone, M., (UOC Medicina Interna, Calipari D., Presidio, Ospedaliero, ASP di Catanzaro), Arcidiacono, G., (UOC Cardiologia e UTIC, Bellanuova I., Catania), Ferraro M., Marigliano G. (ASP Cosenza), Cozzolino, D., Lampitella, A., (Dipartimento di Internistica Clinica e Sperimentale, Acri V., Seconda Università di Napoli), Galasso, D., Mazzei, F., (RSA Madonna di Porto Gimigliano, Galasso S., Catanzaro), (Azienda Ospedaliera della Provincia di Pavia, Buratti A., UO Medicina Interna, Ospedale, Civile, Casorate, Primo, Pavia), Porta, M., (SC Medicina Interna 1U, Brizzi M. F., Azienda, Ospedaliera, Torino), Fattorini, A., Sampietro, F., (Servizio di Coagulazione ed Unità Ricerca Trombosi, D’Angelo A., IRCCS Ospedale San Raffaele, Manfredini, R., Pala, M., (UOC Clinica Medica, Fabbian F., Anna, Azienda Ospedaliera- Universitaria S., Ferrara), Moroni, C., Valente, L., (Laboratorio di Ecocardiografia- Cardiologia Preventiva, Lopreiato F., DAI Cuore, e Grossi Vasi, (UOC Medicina Interna, Parente F., Lecce), (Immunologia Clinica A, Granata M., Moia, M., (Fondazione IRCCS Ca'Granda, Braham S., Ospedale Maggiore Policlinico, Rossi, M., (Dipartimento di Medicina Clinica e Sperimentale, Pesce M., Università di Pisa), Gentile, A., (UO Medicina, Catozzo V., Ldp, Loreto, Baciarello, G., (UOC Cardiologia Preventiva e Riabilitativa, Cosimati A., Ageno, W., Rancan, E., (Dipartimento di Medicina Clinica e Sperimentale, Guasti L., Università, Dell'Insubria, Varese), Ciccaglioni, A., Negri, S., (Centro Elettro-Stimolazione Cardiaca, Polselli M., Prisco, D., (SOD Patologia Medica, Marcucci R., Aou, Careggi, Firenze), Ferro, D., Cangemi, R., Perri, L., Polimeni, L., Catasca, E., Vicario, T., Russo, R., Saliola, M., Del Ben, M., Angelico, F., Calvieri, C., Bucci, T., (I Clinica Medica, Baratta F., Migliacci, R., Medicina Interna, Porciello G. (S. C., Ospedale della Valdichiana, Cortona, Usl, 8 Arezzo), (Dipartimento BioMedico di Medicina Interna e Specialistica, Corrao S., Università degli Studi di, Palermo). Simi Young Internists (GIS) Group: Anzaldi M., Bazzini, C., Bianchi, P. I., Boari, B., Buonauro, A., Buttà, C., Buzzetti, E., Calabria, S., Capeci, W., Caradio, F., Carleo, P., Carrabba, M. D., Castorani, L., Cecchetto, L., Cicco, S., Cimini, C., Colombo, B. M., De Giorgi, A., De Vuono, S., Del Corso, L., Denegri, A., Di Giosia, P., Durante Mangoni, E., Falsetti, L., Forgione, A., Giorgini, P., Grassi, D., Grembiale, A., Hijazi, D., Iamele, L., Lorusso, G., Marchese, A., Marra, A. M., Masala, M., Miceli, G., Montebianco Abenavoli, L., Murgia, G., Naccarato, P., Padula, D., Pattoneri, P., Perego, F., Pesce, P., Piano, S., Pinna, M., Pinto, D., Pretti, V., Pucci, G., Raparelli, V., Salinaro, F., Salzano, A., Santilli, F., Scarpini, F., Scicali, R., Sirico, D., Suppressa, P., Talia, M., Tassone, E. J., Torres, D., Vazzana, N., Vecchio, C. R., Vidili, G., Vitale, F., Zaccone, V., Alessandri, C., Serviddio, G., Palange, P, Greco, E, Bruno, G, Averna, M, Giammanco, A, Sposito, P, De Cristofaro, R., De Gennaro, L, Carulli, L, Pellegrini, E, Cominacini, L, Mozzini, C, Pasini, Af, Sprovieri, M, Spagnuolo, V, Cerqua, G, Cerasola, G, Mulé, G, Barbagallo, M, Lo Sciuto, S, Monteverde, A, Saitta, A, Lo Gullo, A, Malatino, L, Cilia, C, Terranova, V, Pisano, M, Pinto, A, Di Raimondo, D, Tuttolomondo, A, Conigliaro, R, Signorelli, S, De Palma, D, Galderisi, M, Cudemo, G, Galletti, F, Fazio, V, De Luca, N, Meccariello, A, Caputo, D, De Donato, Mt, Iannuzi, A, Bresciani, A, Giunta, R, Utili, R, Iorio, V, Adinolfi, Luigi Elio, Sellitto, A, Iuliano, N, Bellis, P, Tirelli, P, Sacerdoti, D, Vanni, D, Iuliano, L, Ciacciarelli, M, Pacelli, A, Palazzuoli, A, Cacciafesta, M, Gueli, N, Lo Iacono, C, Brusco, S, Verrusio, W, Nobili, L., Tarquinio, N., Pellegrini, F, Vincentelli, G. M., Ravallese, F, Santini, C, Letizia, C, Petramala, L, Zinnamosca, L, Minisola, S., Cilli, M, Savoriti, C, Colangelo, L, Falaschi, P, Martocchia, A, Pastore, F., and DURANTE MANGONI, Emanuele

Subjects
Male, Risk, ABI, ARAPACIS, Atrial fibrillation, Myocardial infarction, Vascular events, Hematology, medicine.medical_specialty, Aged, Aged, 80 and over, Ankle Brachial Index, Atrial Fibrillation, Female, Follow-Up Studies, Humans, Italy, Middle Aged, Predictive Value of Tests, Prospective Studies, Survival Analysis, Vascular Diseases, Population, Socio-culturale, 030204 cardiovascular system & hematology, 03 medical and health sciences, 0302 clinical medicine, atrial fibrillation, ABI, ARAPACIS, myocardial infarction, vascular events, Interquartile range, Internal medicine, myocardial infarction, vascular events, 80 and over, Medicine, Cumulative incidence, 030212 general & internal medicine, education, Prospective cohort study, Stroke, education.field_of_study, business.industry, Hazard ratio, medicine.disease, Cardiology, business, Settore SECS-S/01 - Statistica
Abstract

SummaryAtrial fibrillation (AF) patients are at high risk for thrombotic and vascular events related to their cardiac arrhythmia and underlying systemic atherosclerosis. Ankle-Brachial Index (ABI) is a non-invasive tool in evaluating systemic atherosclerosis, useful in predicting cardiovascular events in general population; no data are available in AF patients. ARAPACIS is a prospective multicentre observational study performed by the Italian Society of Internal Medicine, analysing association between low ABI (≤0.90) and vascular events in NVAF out- or in-patients, enrolled in 136 Italian centres. A total of 2,027 non-valvular AF (NVAF) patients aged > 18 years from both sexes followed for a median time of 34.7 (interquartile range: 22.0–36.0) months, yielding a total of 4,614 patient-years of observation. Mean age was 73 ± 10 years old with 55% male patients. A total of 176 patients (8.7%) experienced a vascular event, with a cumulative incidence of 3.81%/patient-year. ABI≤ 0.90 was more prevalent in patients with a vascular event compared with patients free of vascular events (32.2 vs 20.2%, p< 0.05). On Cox proportional hazard analysis, ABI≤ 0.90 was an independent predictor of vascular events (hazard ratio (HR): 1.394, 95% confidence interval (CI): 1.042–1.866; p=0.02), vascular death (HR: 2.047, 95% CI: 1.255-3.338; p=0.004) and MI (HR: 2.709, 95%> CI: 1.485-5.083; p=0.001). This latter association was also confirmed after excluding patients with previous MI (HR: 2.901, 95% CI: 1.408-5.990, p=0.004). No association was observed between low ABI and stroke/transient ischaemic attack (p=0.91). In conclusion, low ABI is useful to predict MI and vascular death in NVAF patients and may independently facilitate cardiovascular risk assessment in NVAF patients.Note: The review process for this paper was fully handled by C. Weber, Editor in Chief.Listed in the Supplementary Online Appendix Material which is available online at www.thrombosis-online.com.

Published
2016
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127. Repetitive Transcranial Magnetic Stimulation (rTMS) as Preventive Treatment of Chronic Migraine: A Safe Approach with a Promising Effect

Author

Libera, D.D., Colombo, B., Nuara, A., Spagnolo, F., Straffi, L., Chieffo, R., Coppi, E., Di Maggio, G. , Ferrari, L. , Houdayer, E. , Velikova, S. , Zangen, A. , Comi, LEOCANI , ANNUNZIATA MARIA LETIZIA, Libera, D. D., Colombo, B., Nuara, A., Spagnolo, F., Straffi, L., Chieffo, R., Coppi, E., Di, Maggio, G., Ferrari, L., Houdayer, E., Velikova, S., Zangen, A., Comi, and Leocani, ANNUNZIATA MARIA LETIZIA

Published
2013

128. Repetitive transcranial magnetic stimulation (rTMS) in the prophylactic treatment of chronic migraine: a double-blind, randomized, placebo-controlled study

Author

Libera, D.D., Colombo, B., Nuara, A., Straffi, L., Spagnolo, F., Fichera, M., Coppi, E., Ferrari, L., Di Maggio, G. , Houdayer, E. , Chieffo, R. , Zangen, A. , Comi, LEOCANI , ANNUNZIATA MARIA LETIZIA, Libera, D. D., Colombo, B., Nuara, A., Straffi, L., Spagnolo, F., Fichera, M., Coppi, E., Ferrari, L., Di, Maggio, G., Houdayer, E., Chieffo, R., Zangen, A., Comi, and Leocani, ANNUNZIATA MARIA LETIZIA

Published
2013

129. Association of genetic markers with CSF oligoclonal bands in multiple sclerosis patients

Author

Leone, M, Barizzone, N, Esposito, F, Harbo, H, Goris, A, Kockum, I, Oturai, A, Celius, E, Mero, I, Dubois, B, Olsson, T, Søndergaard, H, Cusi, D, Lupoli, S, Andreassen, B, Barcellos, L, Booth, D, Comabella, M, Compston, A, D'Alfonso, S, De Jager, P, Fontaine, B, Hafler, D, Haines, J, Hauser, S, Hawkins, C, Hemmer, B, Hillert, J, Ivinson, A, Martin, R, Martinelli Boneschi, F, Mccauley, J, Oksenberg, J, Patsopoulos, N, Pericak Vance, M, Saarela, J, Sawcer, S, Spurkland, A, Stewart, G, Zipp, F, Myhr, K, Guerini, F, Naldi, P, Galimberti, D, Scarpini, E, Bergamaschi, R, Di Sapio, A, Caputo, D, Rosso, G, Cordera, S, Cavalla, P, Cavallo, R, Benedetti, M, Salvetti, M, Capra, R, Ghezzi, A, Annovazzi, P, Coniglio, G, Liberatore, G, Rodegher, M, Moiola, L, Colombo, B, Radaelli, M, Rossi, P, Martinelli, V, Comi, G, D'Alfonso, S., LUCENTI, AUSILIATRICE, Leone, M, Barizzone, N, Esposito, F, Lucenti, A, Harbo, H, Goris, A, Kockum, I, Oturai, A, Celius, E, Mero, I, Dubois, B, Olsson, T, Søndergaard, H, Cusi, D, Lupoli, S, Andreassen, B, Barcellos, L, Booth, D, Comabella, M, Compston, A, D'Alfonso, S, De Jager, P, Fontaine, B, Hafler, D, Haines, J, Hauser, S, Hawkins, C, Hemmer, B, Hillert, J, Ivinson, A, Martin, R, Martinelli Boneschi, F, Mccauley, J, Oksenberg, J, Patsopoulos, N, Pericak Vance, M, Saarela, J, Sawcer, S, Spurkland, A, Stewart, G, Zipp, F, Myhr, K, Guerini, F, Naldi, P, Galimberti, D, Scarpini, E, Bergamaschi, R, Di Sapio, A, Caputo, D, Rosso, G, Cordera, S, Cavalla, P, Cavallo, R, Benedetti, M, Salvetti, M, Capra, R, Ghezzi, A, Annovazzi, P, Coniglio, G, Liberatore, G, Rodegher, M, Moiola, L, Colombo, B, Radaelli, M, Rossi, P, Martinelli, V, Comi, G, and Villoslada, Pablo

Subjects
Oncology, Male, lcsh:Medicine, Genome-wide association study, Biochemistry, Major Histocompatibility Complex, 0302 clinical medicine, Genetic Marker, Multiple Sclerosi, Genetics of the Immune System, 2.1 Biological and endogenous factors, Aetiology, lcsh:Science, Genetics, adult, female, genetic markers, hla-drb1 chains, humans, male, meta-analysis as topic, middle aged, multiple sclerosis, oligoclonal bands, polymorphism, single nucleotide, young adult, genome-wide association study, biochemistry, genetics and molecular biology (all), agricultural and biological sciences (all), 0303 health sciences, Multidisciplinary, Medicine (all), Single Nucleotide, Middle Aged, Neurology, Medicine, HLA-DRB1 Chain, Female, Research Article, Human, Genetic Markers, Adult, medicine.medical_specialty, Multiple Sclerosis, General Science & Technology, Immunology, Single-nucleotide polymorphism, Human leukocyte antigen, Biology, Autoimmune Disease, Polymorphism, Single Nucleotide, Autoimmune Diseases, 03 medical and health sciences, Young Adult, Meta-Analysis as Topic, Oligoclonal Band, Clinical Research, Internal medicine, medicine, Genetic predisposition, SNP, Humans, PROGRESSO Group, Polymorphism, 030304 developmental biology, Evolutionary Biology, Biochemistry, Genetics and Molecular Biology (all), Population Biology, Multiple sclerosis, Wellcome Trust Case Control Consortium 2, Oligoclonal Bands, Human Genome, lcsh:R, Proteins, Computational Biology, Odds ratio, Major Histocompatibility Antigens, medicine.disease, Demyelinating Disorders, International Multiple Sclerosis Genetics Consortium, PROGEMUS Group, Agricultural and Biological Sciences (all), Genetic marker, Genetic Polymorphism, Clinical Immunology, lcsh:Q, 030217 neurology & neurosurgery, Population Genetics, HLA-DRB1 Chains, Genome-Wide Association Study
Abstract

Objective:to explore the association between genetic markers and Oligoclonal Bands (OCB) in the Cerebro Spinal Fluid (CSF) of Italian Multiple Sclerosis patients.Methods:We genotyped 1115 Italian patients for HLA-DRB1*15 and HLA-A*02. In a subset of 925 patients we tested association with 52 non-HLA SNPs associated with MS susceptibility and we calculated a weighted Genetic Risk Score. Finally, we performed a Genome Wide Association Study (GWAS) with OCB status on a subset of 562 patients. The best associated SNPs of the Italian GWAS were replicated in silico in Scandinavian and Belgian populations, and meta-analyzed.Results:HLA-DRB1*15 is associated with OCB+: p = 0.03, Odds Ratio (OR) = 1.6, 95% Confidence Limits (CL) = 1.1-2.4. None of the 52 non-HLA MS susceptibility loci was associated with OCB, except one SNP (rs2546890) near IL12B gene (OR: 1.45; 1.09-1.92). The weighted Genetic Risk Score mean was significantly (p = 0.0008) higher in OCB+ (7.668) than in OCB- (7.412) patients. After meta-analysis on the three datasets (Italian, Scandinavian and Belgian) for the best associated signals resulted from the Italian GWAS, the strongest signal was a SNP (rs9320598) on chromosome 6q (p = 9.4×10-7) outside the HLA region (65 Mb).Discussion:genetic factors predispose to the development of OCB. © 2013 Leone et al.

Published
2013
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131. Clinical and MRI predictors of response to interferon‐beta and glatiramer acetate in relapsing–remitting multiple sclerosis patients

Author

Romeo, M, Martinelli Boneschi, F, Rodegher, M, Esposito, F, Martinelli V, Colombo, B, Moiola, L, Rossi, P, Poggi, A, Radaelli, M, Perego, E, Straffi, L, Liberatore, G, Dalla Libera, D, De Feo, COMI , GIANCARLO, Romeo, M, Martinelli Boneschi, F, Rodegher, M, Esposito, F, Martinelli, V, Comi, Giancarlo, Colombo, B, Moiola, L, Rossi, P, Poggi, A, Radaelli, M, Perego, E, Straffi, L, Liberatore, G, Dalla Libera, D, and De, Feo

Published
2013

132. Cardiac vagal control as a marker of emotion regulation in healthy adults: A review

Author

Balzarotti, Stefania, Biassoni, Federica, Colombo, Barbara, Ciceri, Maria Rita, Balzarotti, S. (ORCID:0000-0002-9273-8496), Biassoni, F. (ORCID:0000-0002-0375-2211), Colombo, B. (ORCID:0000-0002-4095-9633), Ciceri, M. R. (ORCID:0000-0002-4332-2881), Balzarotti, Stefania, Biassoni, Federica, Colombo, Barbara, Ciceri, Maria Rita, Balzarotti, S. (ORCID:0000-0002-9273-8496), Biassoni, F. (ORCID:0000-0002-0375-2211), Colombo, B. (ORCID:0000-0002-4095-9633), and Ciceri, M. R. (ORCID:0000-0002-4332-2881)

Abstract

In the last two decades, a growing body of theory and research has targeted the role of cardiac vagal control (CVC) in emotional responding. This research has either focused on resting CVC (also denoted as cardiac vagal tone) or phasic changes in CVC (also denoted as vagal reactivity) in response to affective stimuli. The present paper is aimed at reporting a review of the papers published between 1996 and 2016, and focused on the results of 135 papers examining cardiac vagal control as a physiological marker of emotion regulation in healthy adults. The review shows that studies have employed a wide array of methodologies and measures, often leading to conflicting results. High resting CVC has been associated with better down-regulation of negative affect, use of adaptive regulatory strategies, and more flexible emotional responding. Concerning phasic changes, research has consistently found decreased CVC in response to stress, while CVC increases have been shown to reflect either self-regulatory efforts or recovery from stress. Despite conflicting results, we conclude that existing literature supports the use of CVC as a noninvasive, objective marker of emotion regulation.

Published
2017

134. Chromogranin A binds to alphavbeta6-integrin and promotes wound healing in mice

Author

Curnis F, Gasparri AM, Longhi R, Colombo B, D'Alessio S, Pastorino F, Ponzoni M, CORTI , ANGELO, Curnis, F, Gasparri, Am, Longhi, R, Colombo, B, D'Alessio, S, Pastorino, F, Ponzoni, M, and Corti, Angelo

Abstract

Chromogranin A (CgA), a secretory protein expressed by many neuroendocrine cells, neurons, cardiomyocytes, and keratinocytes, is the precursor of various peptides that regulate the carbohydrate/lipid metabolism and the cardiovascular system. We have found that CgA, locally administered to injured mice, can accelerate keratinocyte proliferation and wound healing. This biological activity was abolished by the Asp(45)Glu mutation. CgA and its N-terminal fragments, but not the corresponding Asp(45)Glu mutants, could selectively recognize the alphavbeta6-integrin on keratinocytes (a cell-adhesion receptor that is up-regulated during wound healing) and regulate keratinocyte adhesion, proliferation, and migration. No binding was observed to other integrins such as alphavbeta3, alphavbeta5, alphavbeta8, alpha5beta1, alpha1beta1, alpha3beta1, alpha6beta4, alpha6beta7 and alpha9beta1. Structure-activity studies showed that the entire CgA(39-63) region is crucial for alphavbeta6 recognition (K (i)=7nM). This region contains an RGD site (residues CgA(43-45)) followed by an amphipathic alpha-helix (residues CgA(47-63)), both crucial for binding affinity and selectivity. These results suggest that the interaction of the RGD/alpha-helix motif of CgA with alphavbeta6 regulates keratinocyte physiology in wound healing.

Published
2012

135. MicroRNA and mRNA expression profile screening in multiple sclerosis patients to unravel novel pathogenic steps and identify potential biomarkers

Author

Martinelli Boneschi F, Fenoglio C, Brambilla P, Sorosina M, Giacalone G, Esposito F, Serpente M, Cantoni C, Ridolfi E, Rodegher M, Moiola L, Colombo B, De Riz M, Martinelli V, Scarpini E, Galimberti D., COMI , GIANCARLO, Martinelli Boneschi, F, Fenoglio, C, Brambilla, P, Sorosina, M, Giacalone, G, Esposito, F, Serpente, M, Cantoni, C, Ridolfi, E, Rodegher, M, Moiola, L, Colombo, B, De Riz, M, Martinelli, V, Scarpini, E, Comi, Giancarlo, and Galimberti, D.

Published
2012

137. Optical coherence tomography and visual-evoked potentials: which is more sensitive in multiple sclerosis?

Author

Di Maggio G., Bianco M., Ferrari L., Medaglini S., Rodegher M., Colombo B., Moiola L., Radaelli M., Chieffo R., Del Carro U., Martinelli V., Comi G., LEOCANI , ANNUNZIATA MARIA LETIZIA, Di Maggio, G., Bianco, M., Ferrari, L., Medaglini, S., Rodegher, M., Colombo, B., Moiola, L., Radaelli, M., Chieffo, R., Del Carro, U., Martinelli, V., Comi, G., and Leocani, ANNUNZIATA MARIA LETIZIA

Published
2012

140. Acute myeloid leukemia in Italian patients with multiple sclerosis treated with mitoxantrone

Author

Martinelli V, Cocco E, Capra R, Salemi G, Gallo P, Capobianco M, Pesci I, Ghezzi A, Pozzilli C, Lugaresi A, Bellantonio P, Amato MP, Grimaldi LM, Trojano M, Mancardi GL, Bergamaschi R, Gasperini C, Rodegher M, Straffi L, Ponzio M, Comi G, Italian Mitoxantrone G.r.o.u.p. COLLABORATORS: Radaelli M, Esposito F, Moiola L, Colombo B, Rossi P, Marrosu MG, Frau J, Lorefice L, Coghe G, Savettieri G, Ragonese P, Cusimano V, Perini P, Rinaldi F, Vidali A, Bertolotto A, Malucchi S, Di Sapio A, Montanari E, Guareschi A, Rizzo A, Zaffaroni M, Baldini S, De Rossi N, Cordioli C, Rasia S, Salvetti M, Buttinelli C, Ausili Cefaro L, De Luca G, Tommaso D, Farina D, Fantozzi R, Ruggieri S, Hakiki B, Zipoli V, Portaccio E, Bartolozzi ML, Scandellari C, Stecchi S, Marchello LP, Palmeri B, Vitello G, Iaffaldano P, Lucchese G, Dattola V, Buccafusca M, Sola P, Simone AM, Barreca F, Patti F, Laisa P, Cavalla P, Masera S, Tavazzi E, Galgani S, Sacco R, Provinciali L, Maura D, LUS, Giacomo, Alfieri G, Ticca A, Piras ML, Maimone D, Bianca M, Iudice A, Giro ME, Galeotti M, Florio C, Spitalieri P, La Mantia L, Motti L, Rottoli MR, Granella F, Solaro C, Scarpini E, Servillo G, Cavalletti G., TEDESCHI, Gioacchino, Martinelli, V, Cocco, E, Capra, R, Salemi, G, Gallo, P, Capobianco, M, Pesci, I, Ghezzi, A, Pozzilli, C, Lugaresi, A, Bellantonio, P, Amato, Mp, Grimaldi, Lm, Trojano, M, Mancardi, Gl, Bergamaschi, R, Gasperini, C, Rodegher, M, Straffi, L, Ponzio, M, Comi, G, COLLABORATORS: Radaelli M, Italian Mitoxantrone G. r. o. u. p., Esposito, F, Moiola, L, Colombo, B, Rossi, P, Marrosu, Mg, Frau, J, Lorefice, L, Coghe, G, Savettieri, G, Ragonese, P, Cusimano, V, Perini, P, Rinaldi, F, Vidali, A, Bertolotto, A, Malucchi, S, Di Sapio, A, Montanari, E, Guareschi, A, Rizzo, A, Zaffaroni, M, Baldini, S, De Rossi, N, Cordioli, C, Rasia, S, Salvetti, M, Buttinelli, C, Ausili Cefaro, L, De Luca, G, Tommaso, D, Farina, D, Fantozzi, R, Ruggieri, S, Hakiki, B, Zipoli, V, Portaccio, E, Bartolozzi, Ml, Scandellari, C, Stecchi, S, Marchello, Lp, Palmeri, B, Vitello, G, Iaffaldano, P, Lucchese, G, Dattola, V, Buccafusca, M, Sola, P, Simone, Am, Barreca, F, Patti, F, Laisa, P, Cavalla, P, Masera, S, Tavazzi, E, Galgani, S, Tedeschi, Gioacchino, Sacco, R, Provinciali, L, Maura, D, Lus, Giacomo, Alfieri, G, Ticca, A, Piras, Ml, Maimone, D, Bianca, M, Iudice, A, Giro, Me, Galeotti, M, Florio, C, Spitalieri, P, La Mantia, L, Motti, L, Rottoli, Mr, Granella, F, Solaro, C, Scarpini, E, Servillo, G, and Cavalletti, G.

Published
2011

143. A strange case of waitress headache

Author

Libera DD, Colombo B, Truci G, Rossi P, De Feo D, Tiberi S, Martinelli V, COMI , GIANCARLO, Libera, Dd, Colombo, B, Truci, G, Rossi, P, De Feo, D, Tiberi, S, Martinelli, V, and Comi, Giancarlo

Published
2011

146. lack of replication of KIF-!B gene in an Italian primary progressive multiple sclerosis cohort

Author

MARTINELLI BONESCHI F, ESPOSITO F, SCALABRINI D, FENOGLIO C, RODEGHER ME, BRAMBILLA P, COLOMBO B, GHEZZIA, CAPRA R, COLLIMEDAGLIA L, CONIGLIO G, DE RIX M, SERPENTE M, CANTONI C, SCARPINI E, MARTINELLI V, GALIMBERTI D, COMI , GIANCARLO, MARTINELLI BONESCHI, F, Esposito, F, Scalabrini, D, Fenoglio, C, Rodegher, Me, Brambilla, P, Colombo, B, Ghezzia, Capra, R, Collimedaglia, L, Coniglio, G, DE RIX, M, Serpente, M, Cantoni, C, Scarpini, E, Martinelli, V, Galimberti, D, and Comi, Giancarlo

Published
2010

147. migrainous vertigo and psychiatric disorders

Author

TEGGI R, CALDIROLA D, COLOMBO B, PERNA G, BELLODI, LAURA, BUSSI M, DIZZINESS, COMI , GIANCARLO, Teggi, R, Caldirola, D, Colombo, B, Perna, G, Comi, Giancarlo, Bellodi, Laura, Bussi, M, and Dizziness

Published
2010

148. Validation of 1-year predictive score of long-term response to interferon-β in everyday clinical practice multiple sclerosis patients

Author

Romeo, M, Martinelli, V., Rodegher, M., Perego, E., Maida, S., Sormani, M. P., Comi, G, Moliola, B, Colombo, B, Martinelli-Boneschi, F, De Feo, D, Esposito, F, Liberatore, G, Arianna, M, Messina, M. J., Pavan, G, Radaelli, M, Rocca, M. A., Sangalli, F., Romeo, M, Martinelli, V, Rodegher, M, Perego, E, Maida, S, Sormani, Mp, Comi, G, San Raffaele Multiple Sclerosis Clinical, Group, Including, and Rocca, M

Subjects
Adult, Male, medicine.medical_specialty, Multivariate analysis, Multiple Sclerosis, Relapsing-Remitting, Severity of Illness Index, Outcome Assessment (Health Care), Multiple Sclerosis, Relapsing-Remitting, Interferon β, Internal medicine, Outcome Assessment, Health Care, medicine, Modified Rio score, Humans, Immunologic Factors, Expanded Disability Status Scale, business.industry, Daily clinical practice, Interferon-beta, Multiple sclerosis, Rio score, Disease Progression, Female, Follow-Up Studies, Prognosis, Neurology (clinical), Neurology, Medicine (all), Hazard ratio, medicine.disease, Clinical Practice, Long term response, Cohort, Physical therapy, Settore MED/26 - Neurologia, business
Abstract

Background and purpose The Rio score (RS) and the modified Rio score (MRS) are two scoring systems that can identify the early predictive factors of disability progression in relapsing−remitting multiple sclerosis (RRMS) patients treated with interferon-β (IFN-β). The objective of the study was to validate the usefulness of the RS and MRS in a large cohort of multiple sclerosis patients treated with IFN-β in daily clinical practice. Methods The analysis included a cohort of RRMS patients treated with different formulations of IFN-β for at least 1 year. The RS and MRS were used to classify the patients after 1 year of treatment. Multivariate analysis was performed to identify predictive variables of suboptimal response at 5 years, defined as Expanded Disability Status Scale confirmed progression or switching to a second-line therapy. Results Sixty-nine of 416 included patients were considered as suboptimal responders at 5-year evaluation. The possible score range was 0–3. A higher risk of suboptimal response was found for RS and MRS in the presence of ≥2 scores (hazard ratio 3.0, P = 0.002, and hazard ratio 5.0, P

Published
2015

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