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102. MIS-C and co-infection with P. vivax and P. falciparum in a child: a clinical conundrum

Author

Michela Scalisi, Salvatore Giordano, Laura Antonella Canduscio, Maria Concetta Failla, Luca Messina, Elisa Sferrazza, Raffaella Rubino, Lucia Siracusa, Veronica Vanella, Antonio Cascio, and Claudia Colomba

Subjects
Case report, Multisystem inflammatory syndrome, SARS CoV2, Malaria, COVID-19, Pediatrics, RJ1-570
Abstract

Abstract Background The ongoing Coronavirus Disease 2019 (COVID-19) epidemic represents an unprecedented global health challenge. Many COVID-19 symptoms are similar to symptoms that can occur in other infections. Malaria should always be considered in patients with SARS-CoV-2 infection returning from endemic areas. Case presentation We present the first case of multisystem inflammatory syndrome (MIS-C) and Plasmodium vivax-falciparum and SARS-CoV2 coinfection in children. Despite clearance of parassitaemia and a negative COVID-19 nasopharyngeal PCR, the patient’s clinical conditions worsened. The World Health Organization (WHO) criteria were used to make the diagnosis of MIS-C. Treatment with intravenous immunoglobulins and methylprednisolone was effective. Conclusions This case emphasizes the importance of considering malaria diagnosis in patients returning from endemic areas, even in the COVID 19 era. Malaria and SARS-CoV2 co-infection may increase the risk of MIS-C, for which early detection is critical for proper management.

Published
2022
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103. Vaccination against SARS-CoV-2 protects from morbidity, mortality and sequelae from COVID19 in patients with cancer

Author

Pinato, David J., Evans, Joanne S., Swallow, Judith, Cortellini, Alessio, Hanbury, Georgina, Chung, Chris, Patel, Meera, Dettorre, Gino, Ottaviani, Diego, Chowdhury, Amani, Lee, Alvin JX., Sng, Christopher CT., Yu, Tamara, Shawe-Taylor, Marianne, Bain, Hamish DC., Sinclair, Alasdair, Cooper, Lee, Rogers, Lucy, Belessiotis, Katherine, Murphy, Cian, Bawany, Samira, Khalique, Saira, Andaleeb, Ramis, Bower, Mark, Dalla Pria, Alessia, Sharkey, Rachel, Newsom-Davis, Thomas, Dolly, Saorise, Sita-Lumsde, Ailsa, Apthorp, Eleanor, Jones, Eleanor, Van Hemelrijck, Mieke, Moss, Charlotte, Russell, Beth, Diamantis, Nikolaos, Mukherjee, Uma, Townsend, Sarah, Jackson, Amanda, Loizidou, Angela, Piccart, Martine, Prat, Aleix, Cruz, Claudia A., Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Tabernero, Josep, Aguilar-Company, Juan, Ruiz-Camps, Isabel, Fox, Laura, Garcia Illescas, David, Saoudi, Nadia, Mirallas, Oriol, Roldán, Elisa, Brunet, Joan, Carmona Garcia, MCarmen, Fort-Culillas, Robert, Liñan, Raquel, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Mesia, Ricard, Felip, Eudald, Plaja, Andrea, Cucurull, Marc, Salazar, Ramon, Sureda, Anna, Maluquer, Clara, Gennari, Alessandra, Biello, Federica, D’Avanzo, Francesca, Gaidano, Gianluca, Bruna, Riccardo, Patriarca, Andrea, Ferrante, Daniela, Scotti, Lorenza, Krengly, Marco, Pedrazzoli, Paolo, Rizzo, Gianpiero, Bertuzzi, Alexia, Rossi, Sabrina, Marrari, Andrea, Santoro, Armando, Rimassa, Lorenza, Grosso, Federica, Fusco, Vittorio, Delfanti, Sara, Maconi, Antonio, Betti, Marta, Vincenzi, Bruno, Tonini, Giuseppe, Zambelli, Alberto, Tondini, Carlo, Fotia, Vittoria, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Bertulli, Rossella, Provenzano, Salvatore, Generali, Daniele, Grisanti, Salvatore, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Parisi, Alessandro, Queirolo, Paola, Saponara, Maristella, Giusti, Raffaele, Filetti, Marco, Mazzoni, Francesca, Zoratto, Federica, Tucci, Marco, Berardi, Rossana, Cantini, Luca, Paoloni, Francesco, Guida, Annalisa, Bracarda, Sergio, Martinez-Vila, Clara, Iglesias, Maria, Sanchez de Torre, Ana, Lambertini, Matteo, Perachino, Marta, Pommeret, Fanny, Colomba, Emeline, Lee, Alvin J.X., Sng, Christopher C.T., Carmona-García, M.Carmen, Eremiev, Simeon, Saoudi-Gonzalez, Nadia, Fort-Culillas, Roser, Doonga, Kris, and Aujayeb, Avinash

Published
2022
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104. Outcomes of the SARS-CoV-2 omicron (B.1.1.529) variant outbreak among vaccinated and unvaccinated patients with cancer in Europe: results from the retrospective, multicentre, OnCovid registry study

Author

Evans, Joanne S, Swallow, Judith, Chung, Chris, Patel, Meera, Dettorre, Gino, Ottaviani, Diego, Chowdhury, Amani, Merry, Eve, Chopra, Neha, Lee, Alvin JX, Sng, Christopher CT, Yu, Tamara, Shawe-Taylor, Marianne, Bain, Hamish DC, Wong, Yien Ning Sophia, Galazi, Myria, Benafif, Sarah, Dileo, Palma, Earnshaw, Irina, Patel, Grisma, Wu, Anjui, Soosaipillai, Gehan, Cooper, Lee, Andaleeb, Ramis, Dolly, Saoirse, Apthorp, Eleanor, Srikandarajah, Krishnie, Jones, Eleanor, Van Hemelrijck, Mieke, Moss, Charlotte, Russell, Beth, Chester, John, Loizidou, Angela, Piccart, Martine, Cruz, Claudia A, Reyes, Roxana, Segui, Elia, Marco-Hernández, Javier, Viladot, Margarita, Eremiev, Simeon, Fort-Culillas, Roser, Garcia, Isabel, Liñan, Raquel, Roqué Lloveras, Ariadna, Harbeck, Nadia, Wuerstlein, Rachel, Henze, Franziska, Mahner, Sven, Felip, Eudald, Pous, Anna, D'Avanzo, Francesca, Scotti, Lorenza, Krengli, Marco, Marrari, Andrea, Delfanti, Sara, Maconi, Antonio, Betti, Marta, Tonini, Giuseppe, Di Fazio, Giuseppina Rita, Tondini, Carlo, Chiudinelli, Lorenzo, Franchi, Michela, Libertini, Michela, Bertulli, Rossella, Baggi, Alice, Tovazzi, Valeria, Ficorella, Corrado, Porzio, Giampiero, Saponara, Maristella, Filetti, Marco, Zoratto, Federica, Paoloni, Francesco, Berardi, Rossana, Guida, Annalisa, Bracarda, Sergio, Iglesias, Maria, Sanchez de Torre, Ana, Tagliamento, Marco, Colomba, Emeline, Pommeret, Fanny, Pinato, David J, Aguilar-Company, Juan, Ferrante, Daniela, Hanbury, Georgina, Bower, Mark, Salazar, Ramon, Mirallas, Oriol, Sureda, Anna, Plaja, Andrea, Cucurull, Marc, Mesia, Ricard, Townsend, Sarah, Jackson, Amanda, Dalla Pria, Alessia, Newsom-Davis, Thomas, Handford, Jasmine, Sita-Lumsden, Ailsa, Vincenzi, Bruno, Bertuzzi, Alexia, Brunet, Joan, Lambertini, Matteo, Maluquer, Clara, Pedrazzoli, Paolo, Biello, Federica, Sinclair, Alasdair, Bawany, Samira, Khalique, Saira, Rossi, Sabrina, Rogers, Lucy, Murphy, Cian, Belessiotis, Katherine, Carmona-García, M Carmen, Sharkey, Rachel, García-Illescas, David, Rizzo, Gianpiero, Perachino, Marta, Saoudi-Gonzalez, Nadia, Doonga, Kris, Fox, Laura, Roldán, Elisa, Gaidano, Gianluca, Ruiz-Camps, Isabel, Bruna, Riccardo, Patriarca, Andrea, Martinez-Vila, Clara, Cantini, Luca, Zambelli, Alberto, Giusti, Raffaele, Mazzoni, Francesca, Caliman, Enrico, Santoro, Armando, Grosso, Federica, Parisi, Alessandro, Queirolo, Paola, Aujayeb, Avinash, Rimassa, Lorenza, Prat, Aleix, Tucci, Marco, Grisanti, Salvatore, Mukherjee, Uma, Diamantis, Nikolaos, Fusco, Vittorio, Generali, Daniele, Provenzano, Salvatore, Gennari, Alessandra, Tabernero, Josep, and Cortellini, Alessio

Published
2022
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106. Highlights of Precision Medicine, Genetics, Epigenetics and Artificial Intelligence in Pompe Disease.

Author

Moschetti, Marta, Venezia, Marika, Giacomarra, Miriam, Marsana, Emanuela Maria, Zizzo, Carmela, Duro, Giulia, D'Errico, Annalisa, Colomba, Paolo, and Duro, Giovanni

Subjects
GLYCOGEN storage disease type II, ENZYME deficiency, ENZYME replacement therapy, MUSCLE weakness, ARTIFICIAL intelligence
Abstract

Pompe disease is a neuromuscular disorder caused by a deficiency of the enzyme acid alpha-glucosidase (GAA), which leads to lysosomal glycogen accumulation and progressive development of muscle weakness. Two distinct isoforms have been identified. In the infantile form, the weakness is often severe and leads to motor difficulties from the first few months of life. In adult patients, the progression is slower but can still lead to significant loss of mobility. The current inherent difficulties of the disease lie in both early diagnosis and the use of biomarkers. Given that this is a multifactorial disease, a number of components may exert an influence on the disease process; from the degree of pre-ERT (enzyme replacement therapy) muscle damage to the damaged autophagic system and the different pathways involved. What methodology should be employed to study the complex characteristics of Pompe disease? Our approach relies on the application of genetic and epigenetic knowledge, with a progression from proteomics to transcriptomics. It is also becoming increasingly evident that artificial intelligence is a significant area of interest. The objective of this study is to conduct a comprehensive review of the existing literature on the known data and complications associated with the disease in patients with disorders attributed to Pompe disease. [ABSTRACT FROM AUTHOR]

Published
2025
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107. Identification of Four New Mutations in the GLA Gene Associated with Anderson–Fabry Disease.

Author

Anania, Monia, Pieruzzi, Federico, Giacalone, Irene, Trezzi, Barbara, Marsana, Emanuela Maria, Roggero, Letizia, Francofonte, Daniele, Stefanoni, Michele, Vinci, Martina, Zizzo, Carmela, Zora, Marcomaria, Di Chiara, Tiziana, Duro, Giulia, Duro, Giovanni, and Colomba, Paolo

Subjects
ANGIOKERATOMA corporis diffusum, LYSOSOMAL storage diseases, ENZYME deficiency, SYMPTOMS, X chromosome, MOLECULAR pathology, GALACTOSIDASES
Abstract

Anderson–Fabry disease is a hereditary, progressive, multisystemic lysosomal storage disorder caused by a functional deficiency of the enzyme α-galactosidase A (α-GalA). This defect is due to mutations in the GLA gene, located in the long arm of the X chromosome (Xq21-22). Functional deficiency of the α-GalA enzyme leads to reduced degradation and accumulation of its substrates, predominantly globotriaosylceramide (Gb3), which accumulate in the lysosomes of numerous cell types, giving rise to the symptomatology. Clinical diagnosis can still be difficult today due to the peculiarities of the disease, which presents with clinical manifestations that overlap with those of other pathologies and a wide possibility of differential diagnoses, which lead to missed diagnoses, misdiagnosis, or a diagnostic delay. Patients with clinical suspicion of Fabry disease undergo a diagnostic workup that includes an evaluation of α-GALA enzyme activity, genetic analysis of the GLA gene, and the measurement of blood Lyso-Gb3, a soluble derivative of Gb3. In this paper, we describe four novel mutations identified in the GLA gene which are associated with absent or reduced α-GalA activity, pathological accumulation of the specific substrate, and characteristic clinical manifestations of Fabry disease. We identified two mutations (c.583insGAATA and p.Y207X) that result in the formation of a premature translation stop codon, resulting in a truncated protein and thus a completely non-functional enzyme. The other two identified gene alterations (p.G261C and c.786G>T, which determine p.W262C) are missense mutations that cause reduced α-GALA activity, the accumulation of blood Lyso-Gb3, and symptoms consistent with Fabry disease, and therefore may be associated with this disorder. The identification of these new mutations in patients with symptoms attributable to Fabry disease increases the molecular knowledge of the GLA gene and provides important support to the clinician, for a more accurate and timely diagnosis of the pathology. [ABSTRACT FROM AUTHOR]

Published
2025
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108. The Identification of a Novel Pathogenic Variant of the GLA Gene Associated with a Classic Phenotype of Anderson–Fabry Disease: A Clinical and Molecular Study.

Author

Giacalone, Irene, Ruzzi, Luigina, Anania, Monia, Cuonzo, Mariateresa, Marsana, Emanuela Maria, Mastrippolito, Silvia, Francofonte, Daniele, Bucco, Silvia, D'Errico, Annalisa, Longo, Maria Olimpia, Zizzo, Carmela, Iarlori, Luigia, Duro, Giovanni, and Colomba, Paolo

Subjects
ANGIOKERATOMA corporis diffusum, LEFT ventricular hypertrophy, LYSOSOMAL storage diseases, GENETIC variation, ENZYME deficiency, GALACTOSIDASES
Abstract

Anderson–Fabry (or Fabry) disease is a rare lysosomal storage disorder caused by a functional deficiency of the enzyme alpha-galactosidase A. The partial or total defect of this lysosomal enzyme, which is caused by variants in the GLA gene, leads to the accumulation of glycosphingolipids, mainly globotriaosylceramide in the lysosomes of different cell types. The clinical presentation of Fabry disease is multisystemic and can vary depending on the specific genetic variants associated with the disease. To date, more than 1000 different variants have been identified in the human GLA gene, including missense and nonsense variants, as well as small and large insertions or deletions. The identification of novel variants in individuals exhibiting symptoms indicative of Fabry disease, expands the molecular comprehension of the GLA gene, providing invaluable insights to physicians in the diagnosis of the disease. In this article, we present the case of two members of the same family, mother and son, in whom a new pathogenic variant was identified. This variant has not been previously described in the literature and is not present in databases. The two family members presented with a number of typical clinical manifestations of the disease, including cornea verticillata, neuropathic pain, left ventricular hypertrophy, angiokeratomas and abdominal pain. The son, but not his mother, showed reduced alpha-galactosidase A activity, while high levels of Lyso-Gb3 in the blood, a specific substrate accumulation biomarker, were found in both. Sequencing of the GLA gene revealed the presence of a variant, c.484delT, which is characterised by the deletion of a single nucleotide, a thymine, in exon 3 of the gene. This results in a frameshift variant, which introduces a premature stop codon, thereby generating a truncated and consequently non-functional protein. Therefore, the clinical and laboratory data indicate that the novel p.W162Gfs*3 variant described herein is associated with the classical form of Fabry disease. [ABSTRACT FROM AUTHOR]

Published
2025
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110. Monitoring Over Time of Pathological Complete Response to Neoadjuvant Chemotherapy in Breast Cancer Patients Through an Ensemble Vision Transformers‐Based Model.

Author

Comes, Maria Colomba, Fanizzi, Annarita, Bove, Samantha, Boldrini, Luca, Latorre, Agnese, Guven, Deniz Can, Iacovelli, Serena, Talienti, Tiziana, Rizzo, Alessandro, Zito, Francesco Alfredo, and Massafra, Raffaella

Subjects
TRANSFORMER models, CONTRAST-enhanced magnetic resonance imaging, MAGNETIC resonance imaging, NEOADJUVANT chemotherapy, CANCER chemotherapy, BREAST cancer
Abstract

Background: Morphological and vascular characteristics of breast cancer can change during neoadjuvant chemotherapy (NAC). Dynamic contrast‐enhanced magnetic resonance imaging (DCE‐MRI)‐acquired pre‐ and mid‐treatment quantitatively capture information about tumor heterogeneity as potential earlier indicators of pathological complete response (pCR) to NAC in breast cancer. Aims: This study aimed to develop an ensemble deep learning‐based model, exploiting a Vision Transformer (ViT) architecture, which merges features automatically extracted from five segmented slices of both pre‐ and mid‐treatment exams containing the maximum tumor area, to predict and monitor pCR to NAC. Materials and Methods: Imaging data analyzed in this study referred to a cohort of 86 breast cancer patients, randomly split into training and test sets at a ratio of 8:2, who underwent NAC and for which information regarding the pCR status was available (37.2% of patients achieved pCR). We further validated our model using a subset of 20 patients selected from the publicly available I‐SPY2 trial dataset (independent test). Results: The performances of the proposed model were assessed using standard evaluation metrics, and promising results were achieved: area under the curve (AUC) value of 91.4%, accuracy value of 82.4%, a specificity value of 80.0%, a sensitivity value of 85.7%, precision value of 75.0%, F‐score value of 80.0%, and G‐mean value of 82.8%. The results obtained from the independent test show an AUC of 81.3%, an accuracy of 80.0%, a specificity value of 76.9%, a sensitivity of 85.0%, a precision of 66.7%, an F‐score of 75.0%, and a G‐mean of 81.2%. Discussion: As far as we know, our research is the first proposal using ViTs on DCE‐MRI exams to monitor pCR over time during NAC. Conclusion: Finally, the changes in DCE‐MRI at pre‐ and mid‐treatment could affect the accuracy of pCR prediction to NAC. [ABSTRACT FROM AUTHOR]

Published
2024
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111. Stoma Acceptance Mediates Body Image Distress and Mental Health-Related Quality of Life: A Single-Center Study on Radical Cystectomy Patients with Ureterostomy.

Author

Muzii, Benedetta, Di Bello, Francesco, Collà Ruvolo, Claudia, Morra, Simone, Polverino, Federico, Pessolano, Colomba, Creta, Massimiliano, Califano, Gianluigi, Pezone, Gabriele, Mangiapia, Francesco, Alvino, Pierluigi, Longo, Nicola, and Maldonato, Nelson Mauro

Subjects
MENTAL imagery, QUALITY of life, CANCER invasiveness, PSYCHOLOGICAL distress, SURGICAL stomas, BODY image
Abstract

Background: Muscle-invasive bladder cancer and subsequent radical cystectomy with ureterocutaneostomy significantly impact patients' body image and quality of life, potentially increasing the risk of adverse mental health outcomes. Acceptance may represent a psychosocial resource to buffer the effects of body image impairment on health, thereby supporting stoma adjustment and preserving quality of life. Objective: This study aimed to investigate the mediating role of stoma acceptance in the relationship between body image distress and mental health. Methods: A single-center cross-sectional survey was conducted with 73 muscle-invasive bladder cancer patients undergoing radical cystectomy with ureterocutaneostomy. Participants completed structured, anonymous self-report measures assessing body image distress, stoma acceptance, and mental health-related quality of life through validated questionnaires. Results: Statistical analyses revealed significant negative correlations between body image distress and mental health and stoma acceptance. Conversely, stoma acceptance was significantly and positively associated with mental health. Regression-based mediation modeling indicated that stoma acceptance exerted a significant mediating effect on the relationship between body image and mental health-related quality of life. Conclusions: These findings highlight the considerable and unprecedented role of stoma acceptance as a mediating factor that may promote the adjustment and enhance the quality of life of urostomy patients. Further research is warranted to explore interventions targeting stoma acceptance to prevent body image distress and promote mental health. [ABSTRACT FROM AUTHOR]

Published
2024
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112. What do 'local elites' seek from EU security policies in the Sahel? Re-thinking the agency of non-European actors.

Author

Colomba-Petteng, Léonard

Subjects
*ELITE (Social sciences), *ETHNOLOGY research, *SECURITY sector, *EUROCENTRISM, *INTERNATIONAL relations, *EXTRAVERSION
Abstract

The European Union (EU) has been attempting to promote stability in the Sahel since 2011 through capacity-building missions in the security and defence sectors. These policy instruments have been criticised for their limited effectiveness. To explain it, a common argument claims that 'local elites' lack ownership and political engagement. This article opposes such rationale and suggests that we need to rethink the agency of non-European actors beyond a Eurocentric conceptual toolbox ('resistance', 'fragility', 'ownership'). Building on an ethnography of the European capacity-building mission in support of security forces in Niger (EUCAP Sahel), this article shows that Nigerien elites regard the EU as an economic resource rather than a genuine security actor. Therefore, they primarily seek economic profits, material advantages, and professional opportunities from EU security policies. The argument proceeds in three steps. The first part intends to refine the broad category of 'local elites'. I suggest an inductive distinction that helps simplify our understanding of the agential practices of non-European actors. The second part uses this inductive distinction to foreground different strategies of Nigerien elites to make the most out of EU security policies. Third, the article discusses both the theoretical and policy implications of these empirical findings. [ABSTRACT FROM AUTHOR]

Published
2024
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113. Severe Panton–Valentine-Leukocidin-Positive Staphylococcus aureus Infections in Pediatric Age: A Case Report and a Literature Review.

Author

Garbo, Valeria, Venuti, Laura, Boncori, Giovanni, Albano, Chiara, Condemi, Anna, Natoli, Giuseppe, Frasca Polara, Valentina, Billone, Sebastiano, Canduscio, Laura Antonella, Cascio, Antonio, and Colomba, Claudia

Subjects
STAPHYLOCOCCUS aureus infections, VENOUS thrombosis, METHICILLIN-resistant staphylococcus aureus, THERAPEUTICS, CHILD patients
Abstract

Background: Infections caused by S. aureus strains encoding Panton–Valentine leukocidin (PVL-SA) have become increasingly relevant in community settings and can cause severe conditions in pediatric populations. We present the pediatric case of an invasive disease caused by PVL-SA and provide a literature review of severe manifestations caused by these strains in children. Methods: A PubMed search (February 2024) found studies that included relevant clinical outcomes, diagnostics, and treatments, excluding cases of asymptomatic infection or in adult populations. A logistical multivariate analysis was used to find predictors of the need for intensive care. Results: A 10-year-old boy came to the attention of our Pediatric Infectious Diseases Unit with fever, chest pain, and tachypnea. A rapid worsening of his clinical conditions was observed, with the development of necrotizing pneumonia, osteomyelitis, deep vein thrombosis (DVT), and multiple abscesses. Blood cultures confirmed the presence of PVL-producing methicillin-resistant S. aureus (MRSA). The initial treatment included linezolid and ceftaroline and was later adjusted to clindamycin, daptomycin, and fosfomycin, with clinical improvement. Discussion: Our review collected 36 articles, including 156 pediatric cases of severe PVL-SA infection. Bacteremia was present in 49% of cases, lung infection in 47%, and osteomyelitis in 37%. The presence of pulmonary localization was predictive of the need for intensive care, O.R. 25.35 (7.46–86.09; p < 0.001). Anti-toxin molecules were used in about half the cases where information on treatment was reported. Our report highlights the capacity of PVL-SA to cause life-threatening complications in children, while also discussing the full range of its clinical spectrum and the most effective therapeutic approaches. [ABSTRACT FROM AUTHOR]

Published
2024
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114. Real-World Use of Dalbavancin for Treatment of Soft Tissue and Bone Infection in Children: Safe, Effective and Hospital-Time Sparing

Author

Désirée Caselli, Marcello Mariani, Claudia Colomba, Chiara Ferrecchi, Claudio Cafagno, Daniela Trotta, Ines Carloni, Daniela Dibello, Elio Castagnola, and Maurizio Aricò

Subjects
dalbavancin, soft tissue infection, acute bacterial skin and skin structure infections (ABSSSIs), bone infection, Pediatrics, RJ1-570
Abstract

Acute bacterial skin and skin structure infections (ABSSSI) and osteoarticular infections compound the burden of morbidity, mortality and prolonged hospitalizations among gram-positive infections. Dalbavancin, a second-generation, intravenous lipoglycopeptide, due to its prolonged half-life, can be a valuable alternative in their treatment when administered as inpatient treatment at the price of an extended hospital stay. Between October 2019 and September 2023, 31 children and adolescents were treated with dalbavancin because of bone and joint infections (n = 12 patients, 39%), ABSSSI (n = 13 patients, 42%), mainly for the limbs, facial cellulitis or complicated ABSSSI (n = 6 patients, 19%), at five Italian pediatric centers. Microbiological study provided gram-positive bacterial isolate in 16 cases, in 11 cases from a positive blood culture; 9 of them were MRSA. Twenty-five patients were initially treated with a different antibiotic therapy: beta-lactam-based in 18 patients (58%), glycopeptide-based in 15 patients (48%) and daptomycin in 6 (19%). The median time that elapsed between admission and start of dalbavancin was 18 days. A total of 61 doses of dalbavancin were administered to the 31 patients: 16 received a single dose while the remaining 15 patients received between two (n = 9) and nine doses. The frequency of administration was weekly in five cases or fortnightly in nine patients. Median length of stay in hospital was 16 days. Median time to discharge after the first dose of dalbavancin was 1 day. Treatment was very well-tolerated: of the 61 administered doses, only four doses, administered to four patients, were associated with an adverse event: drug extravasation during intravenous administration occurred in two patients, with no sequelae; however, in two patients the first administration was stopped soon after infusion start: in one (ID #11), due to headache and vomiting; in another (ID #12) due to a systemic reaction. In both patients, drug infusion was not repeated. None of the remaining 29 patients reported treatment failure (resistant or recurrent disease) or an adverse effect during a median follow-up time of two months. The use of dalbavancin was safe, feasible and also effective in shortening the hospital stay in children and adolescents.

Published
2024
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115. Tuberculous Pericarditis in Childhood: A Case Report and a Systematic Literature Review

Author

Laura Venuti, Anna Condemi, Chiara Albano, Giovanni Boncori, Valeria Garbo, Sara Bagarello, Antonio Cascio, and Claudia Colomba

Subjects
tuberculosis, pericarditis, pericardial effusion, tuberculous pericarditis, childhood, pediatric tuberculosis, Medicine
Abstract

Tuberculous pericarditis (TBP) is an important cause of pericarditis worldwide while being infrequent in childhood, especially in low-TB-incidence countries. We report a case of TBP and provide a systematic review of the literature, conducted by searching PubMed, Scopus, and Cochrane to find cases of TBP in pediatric age published in the English language between the year 1990 and the time of the search. Of the 587 search results obtained, after screening and a backward citation search, 45 studies were selected to be included in this review, accounting for a total of 125 patients. The main signs and symptoms were fever, cough, weight loss, hepatomegaly, dyspnea, and increased jugular venous pressure or jugular vein turgor. A definitive diagnosis of TBP was made in 36 patients, either thanks to microbiological investigations, histological analysis, or both. First-line antitubercular treatment (ATT) was administered in nearly all cases, and 69 children underwent surgical procedures. Only six patients died, and only two died of TBP. TBP in childhood is relatively uncommon, even in high-TB-prevalence countries. Clinical manifestations, often suggestive of right-sided cardiac failure, are subtle, and diagnosis is challenging. TBP has an excellent prognosis in childhood; however, in a significant proportion of cases, invasive surgical procedures are necessary.

Published
2024
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118. Long-term Outcome of Children Born to Women with Autoimmune Rheumatic Diseases: A Multicentre, Nationwide Study on 299 Randomly Selected Individuals

Author

Andreoli, Laura, Nalli, Cecilia, Lazzaroni, Maria Grazia, Carini, Chiara, Dall’Ara, Francesca, Reggia, Rossella, Rodrigues, Marília, Benigno, Carolina, Baldissera, Elena, Bartoloni, Elena, Basta, Fabio, Bellisai, Francesca, Bortoluzzi, Alessandra, Campochiaro, Corrado, Cantatore, Francesco Paolo, Caporali, Roberto, Ceribelli, Angela, Chighizola, Cecilia B., Conigliaro, Paola, Corrado, Addolorata, Cutolo, Maurizio, D’Angelo, Salvatore, De Stefani, Elena, Doria, Andrea, Favaro, Maria, Fischetti, Colomba, Foti, Rosario, Gabrielli, Armando, Generali, Elena, Gerli, Roberto, Gerosa, Maria, Larosa, Maddalena, Maier, Armin, Malavolta, Nazzarena, Meroni, Marianna, Meroni, Pier Luigi, Montecucco, Carlomaurizio, Mosca, Marta, Padovan, Melissa, Paolazzi, Giuseppe, Pazzola, Giulia, Peccatori, Susanna, Perricone, Roberto, Pettiti, Giorgio, Picerno, Valentina, Prevete, Immacolata, Ramoni, Véronique, Romeo, Nicoletta, Ruffatti, Amelia, Salvarani, Carlo, Sebastiani, Gian Domenico, Selmi, Carlo, Serale, Francesca, Sinigaglia, Luigi, Tani, Chiara, Trevisani, Marica, Vadacca, Marta, Valentini, Eleonora, Valesini, Guido, Visalli, Elisa, Vivaldelli, Ester, Zuliani, Lucia, and Tincani, Angela

Published
2022
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120. Molecular analysis of Lepidopleurus cajetanus (Poli, 1791) (Polyplacophora, Leptochitonidae) from the Mediterranean and near Atlantic

Author

Mariastella Colomba, Julia D. Sigwart, Walter Renda, Armando Gregorini, Maurizio Sosso, and Bruno Dell’Angelo

Subjects
Zoology, QL1-991
Abstract

In the present paper we used a molecular data set (including mitochondrial partial 16S rRNA and COI gene sequences) to examine the genetic structure of Lepidopleurus cajetanus (Poli, 1791) (Polyplacophora, Leptochitonidae) - a distinctive shallow water chiton and member of the basal branching Lepidopleurida, which is widespread in and adjacent to the Mediterranean. The analyses of the two mt-standard marker fragments resolved two main discrete clusters reported as L. cajetanus s.s. and L. aff. cajetanus, respectively. Lepidopleurus cajetanus s.s. is widespread throughout the area under study, while the second distinct lineage apparently co-occurs on the eastern Spanish mainland coast of the Balearic Sea. This result is discussed comparing our data with those reported, in 2014, by Fernández and colleagues who described L. cajetanus as exhibiting “a ‘chaotic patchiness’ pattern defined by a high genetic variability with locality-exclusive haplotypes, high genetic divergence, and a lack of geographic structure”. Although genetic data alone are not sufficient to draw any definitive conclusions, nevertheless we believe that present results shed new light on L. cajetanus which apparently shows more geographically patterned genetic structure than supposed so far.

Published
2022
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121. A ultrasound-based radiomic approach to predict the nodal status in clinically negative breast cancer patients

Author

Samantha Bove, Maria Colomba Comes, Vito Lorusso, Cristian Cristofaro, Vittorio Didonna, Gianluca Gatta, Francesco Giotta, Daniele La Forgia, Agnese Latorre, Maria Irene Pastena, Nicole Petruzzellis, Domenico Pomarico, Lucia Rinaldi, Pasquale Tamborra, Alfredo Zito, Annarita Fanizzi, and Raffaella Massafra

Subjects
Medicine, Science
Abstract

Abstract In breast cancer patients, an accurate detection of the axillary lymph node metastasis status is essential for reducing distant metastasis occurrence probabilities. In case of patients resulted negative at both clinical and instrumental examination, the nodal status is commonly evaluated performing the sentinel lymph-node biopsy, that is a time-consuming and expensive intraoperative procedure for the sentinel lymph-node (SLN) status assessment. The aim of this study was to predict the nodal status of 142 clinically negative breast cancer patients by means of both clinical and radiomic features extracted from primary breast tumor ultrasound images acquired at diagnosis. First, different regions of interest (ROIs) were segmented and a radiomic analysis was performed on each ROI. Then, clinical and radiomic features were evaluated separately developing two different machine learning models based on an SVM classifier. Finally, their predictive power was estimated jointly implementing a soft voting technique. The experimental results showed that the model obtained by combining clinical and radiomic features provided the best performances, achieving an AUC value of 88.6%, an accuracy of 82.1%, a sensitivity of 100% and a specificity of 78.2%. The proposed model represents a promising non-invasive procedure for the SLN status prediction in clinically negative patients.

Published
2022
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122. COVID-19 and neurological disorders: what might connect Parkinson’s disease to SARS-CoV-2 infection

Author

Salvatore Iacono, Giuseppe Schirò, Chiara Davì, Sergio Mastrilli, Michelle Abbott, Fabrizio Guajana, Valentina Arnao, Paolo Aridon, Paolo Ragonese, Cesare Gagliardo, Claudia Colomba, Nicola Scichilone, and Marco D’Amelio

Subjects
Parkinson’s disease, COVID-19, SARS-CoV-2, risk factors, neurodegenerative diseases, neuroepidemiology, Neurology. Diseases of the nervous system, RC346-429
Abstract

SARS-CoV-2 infection leading to Coronavirus disease 19 (COVID-19) rapidly became a worldwide health emergency due to its elevated infecting capacity, morbidity, and mortality. Parkinson’s disease (PD) is the second most common neurodegenerative disorder and, nowadays the relationship between SARS-CoV-2 outbreak and PD reached a great interest. Apparently independent one from the other, both diseases share some pathogenetic and clinical features. The relationship between SARS-CoV-2 infection and PD is complex and it depends on the direction of the association that is which of the two diseases comes first. Some evidence suggests that SARS-CoV-2 infection might be a possible risk factor for PD wherein the exposure to SARS-CoV-2 increase the risk for PD. This perspective comes out from the increasing cases of parkinsonism following COVID-19 and also from the anatomical structures affected in both COVID-19 and early PD such as olfactory bulb and gastrointestinal tract resulting in the same symptoms such as hyposmia and constipation. Furthermore, there are many reported cases of patients who developed hypokinetic extrapyramidal syndrome following SARS-CoV-2 infection although these would resemble a post-encephalitic conditions and there are to date relevant data to support the hypothesis that SARS-CoV-2 infection is a risk factor for the development of PD. Future large, longitudinal and population-based studies are needed to better assess whether the risk of developing PD after COVID-19 exists given the short time span from the starting of pandemic. Indeed, this brief time-window does not allow the precise estimation of the incidence and prevalence of PD after pandemic when compared with pre-pandemic era. If the association between SARS-CoV-2 infection and PD pathogenesis is actually putative, on the other hand, vulnerable PD patients may have a greater risk to develop COVID-19 being also more prone to develop a more aggressive disease course. Furthermore, PD patients with PD showed a worsening of motor and non-motor symptoms during COVID-19 outbreak due to both infection and social restriction. As well, the worries related to the risk of being infected should not be neglected. Here we summarize the current knowledge emerging about the epidemiological, pathogenetic and clinical relationship between SARS-CoV-2 infection and PD.

Published
2023
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125. Sarilumab in adults hospitalised with moderate-to-severe COVID-19 pneumonia (CORIMUNO-SARI-1): An open-label randomised controlled trial

Author

Mariette, Xavier, Hermine, Olivier, Tharaux, Pierre-Louis, Resche-Rigon, Matthieu, Porcher, Raphael, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Pourchet-Martinez, Valérie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Dalibey, Sarah, Raked, Nabil, Mameri, Lakhdar, Alary, Stéphanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Montlahuc, Claire, Biard, Lucie, Charreteur, Robin, Dupré, Celine, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Pavot, Arthur, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Bulifon, Sophie, Jaïs, Xavier, Sitbon, Olivier, Pavy, Stéphan, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stéphane, Baudry, Elodie, Verny, Christiane, Noaillon, Mathilde, Lefèvre, Edouard, Zaidan, Mohamad, Le Tiec, Clotilde Le Tiec, Verstuyft, Céline, Roques, Anne-Marie, Grimaldi, Lamiae, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Solène, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Georgin-Lavialle, Sophie, Senet, Patricia, Pialoux, Gilles, Soria, Angèle, Parrot, Antoine, François, Hélène, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadège, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefèvre, Guillaume, Fallet, Vincent, Gottenberg, Jacques-Eric, Hansmann, Yves, Andres, Emmanuel, Bayer, Sophie, Becker, Guillaume, Blanc, Frédéric, Brin, Stéphane, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Demonsant, Eric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurélien, Heger, Bob, Hutt, Anne, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Martin, Tristan, Mertes, Paul Michel, Metzger, Catherine, Meyer, Nicolas, Nisand, Gabriel, Noll, Eric, Oberlin, Mathieu, Ohlmann-Caillard, Sophie, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Sublon, Cédric, Tayebi, Hakim, Weill, François, Mekinian, Arsène, Abisror, Noémie, Jachiet, Vincent, Chopin, Dorothée, Fain, Olivier, Garnier, Marc, Krause le Garrec, Jessica, Morgand, Marjolaine, Pacanowski, Jerome, Urbina, Tomas, McAvoy, Chloe, Pereira, Maria, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Daguenel-Nguyen, Anne, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean-Sébastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Penet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Jesuthasan, Denis, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Valérie, Tréhan, Anne, Vigna, Véronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charléne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, F-Xavier, Ghosn, Jade, BACHELARD, Antoine, BIRONNE, Timothee, BORIE, Raphael, BOUNHIOL, Agathe, BOUSSARD, Catherine, CHAUFFiER, Jeanne, CHALAL, Solaya, CHALAL, Lynda, CHANSOMBAT, Malikhone, CRESPIN, Paul, CRESTANI, Bruno, DACONCEICAO, Olivia, DECONINCK, Laurene, DIEUDE, Philippe, DOSSIER, Antoine, DUBERT, Marie, DUCROCQ, Greggory, FUENTES, Axelle, GERVAIS, Anne, GILBERT, Marie, ISERNIA, Valentina, ISMAEL, Sophie, JOLY, Veronique, JULIA, Zelie, LARIVEN, Sylvie, LE GAC, Sylvie, LE PLUART, Diane, LOUNI, Francoise, NDIAYE, Awa, PAPO, Thomas, PARISEY, Marion, PHUNG, Bao, POURBAIX, Annabelle, RACHLINE, Anne, RIOUX, Christophe, SAUTEREAU, Aurelie, STEG, Gabriel, TARHINI, Hassan, VALAYER, Simon, VALLOIS, Dorothee, VERMES, Paul, VOLPE, Thomas, Nguyen, Yann, Honsel, Vasco, Weiss, Emmanuel, Codorniu, Anaïs, Zarrouk, Virginie, De Lastours, Victoire, Uzzan, Matthieu, Olivier, Olivier, Rossi, Geoffrey, Gamany, Naura, Rahli, Roza, Louis, Zeina, Boutboul, David, Galicier, Lionel, Amara, Yaël, Archer, Gabrielle, Benattia, Amira, Bergeron, Anne, Bondeelle, Louise, De Castro, Nathalie, Clément, Melissa, Darmont, Michaël, Denis, Blandine, Dupin, Clairelyne, Feredj, Elsa, Feyeux, Delphine, Joseph, Adrien, Lengliné, Etienne, Le Guen, Pierre, Liégeon, Geoffroy, Lorillon, Gwenaël, Mabrouki, Asmaa, Mariotte, Eric, Martin de Frémont, Grégoire, Mirouse, Adrien, Molina, Jean-Michel, Peffault de Latour, Régis, Oksenhendler, Eric, Saussereau, Julien, Tazi, Abdellatif, Tudesq, Jean-Jacques, Zafrani, Lara, Brindele, Isabelle, Bugnet, Emmanuelle, Celli Lebras, Karine, Chabert, Julien, Djaghout, Lalia, Fauvaux, Catherine, Jegu, Anne Lise, Kozaliewicz, Ewa, Meunier, Martine, Tremorin, Marie-Thérèse, Davoine, Claire, Madeleine, Isabelle, Caillat-Zucman, Sophie, Delaugerre, Constance, Morin, Florence, SENE, Damien, BURLACU, Ruxandra, CHOUSTERMAN, Benjamin, MEGARBANE, Bruno, RICHETTE, Pascal, RIVELINE, Jean-Pierre, FRAZIER, Aline, VICAUT, Eric, BERTON, Laure, HADJAM, Tassadit, VASQUEZ-IBARRA, Miguel Alejandro, JOURDAINE, Clément, JACOB, Aude, SMATI, Julie, RENAUD, Stéphane, MANIVET, Philippe, PERNIN, Claire, SUAREZ, Lydia, Semerano, Luca, ABAD, Sebastien, Benainous, Ruben, Bloch Queyrat, Coralie, Bonnet, Nicolas, Brahmi, Sabrina, Cailhol, johann, Cohen, Yves, Comparon, Celine, Cordel, Hugues, Dhote, Robin, Dournon, Nathalie, Duchemann, Boris, Ebstein, Nathan, Giroux-Leprieur, Benedicte, Goupil de Bouille, Jeanne, Jacolot, Anne, Nunes, Hilario, Oziel, Johanna, Rathouin, Vanessa, Rigal, Marthe, Roulot, Dominique, Tantet, Claire, Uzunhan, Yurdagul, COSTEDOAT-CHALUMEAU, Nathalie, Ait Hamou, Zakaria, Benghanem, Sarah, BLANCHE, Philippe, CANOUI, Etienne, CARLIER, Nicolas, CHAIGNE, Benjamin, CONTEJEAN, Adrien, DUNOGUE, Bertrand, DUPLAND, Pierre, DUREL - MAURISSE, Aurélie, GAUZIT, Remy, JAUBERT, Paul, Joumaa, Hassan, Jozwiak, Mathieu, KERNEIS, Solen, LACHATRE, Marie, Lafoeste, Hélène, LEGENDRE, Paul, LUONG NGUYEN, Liem Binh, MAREY, Jonathan, MORBIEU, Caroline, MOUTHON, Luc, NGUYEN, Lee, Palmieri, Lola-Jade, REGENT, Alexis, SZWEBEL, Tali-Anne, TERRIER, Benjamin, GUERIN, Corinne, ZERBIT, Jérémie, CHEREF, Kahina, CHITOUR, Kamil, CISSE, Mamadou Salif, CLARKE, Ada, CLAVERE, Gaelle, DUSANTER, Isabelle, GAUDEFROY, Caroline, JALLOULI, Moez, KOLTA, Sami, LE BOURLOUT, Catherine, MARIN, Nathalie, MENAGE, Nathalie, MOORES, Alexandre, PEIGNEY, Isabelle, PIERRON, Cédric, SALEH-MGHIR, Samira, VALLET, Mathilde, MICHEL, Marc, MELICA, Giovanna, LELIEVRE, Jean-Daniel, FOIS, Elena, LIM, Pascal, MATIGNON, Marie, GUILLAUD, Constance, THIEMELE, Alaki, SCHMITZ, David, BOUHRIS, Marion, BELAZOUZ, Syllia, LANGUILLE, Laetitia, MEKONTSO-DESSAPS, Armand, SADAOUI, Thiziri, Mayaux, Julien, Cacoub, Patrice, Corvol, Jean-Christophe, Louapre, Céline, Sambin, Sara, Mariani, Louise-Laure, Karachi, Carine, Tubach, Florence, Estellat, Candice, Gimeno, Linda, Martin, Karine, Bah, Aïcha, Keo, Vixra, Ouamri, Sabrine, Messaoudi, Yasmine, Yelles, Nessima, Faye, Pierre, Cavelot, Sébastien, Larcheveque, Cecile, Annonay, Laurence, Benhida, Jaouad, Zahrate-Ghoul, Aida, Hammal, Soumeya, Belilita, Ridha, Lecronier, Marie, Beurton, Alexandra, Haudebourg, Luc, Deleris, Robin, Le Marec, Julien, Virolle, Sara, Nemlaghi, Safaa, Bureau, Côme, Mora, Pierre, De Sarcus, Martin, Clovet, Olivier, Duceau, Baptiste, Grisot, Paul Henri, Pari, Marie hélène, Arzoine, Jérémy, Clarac, Ulrich, Faure, Morgane, Delemazure, Julie, Decavele, Maxence, Morawiec, Elise, Demoule, Alexandre, Dres, Martin, Vautier, Mathieu, Allenbach, Yves, Benveniste, Olivier, Leroux, Gaelle, Rigolet, Aude, Guillaume-Jugnot, Perrine, Domont, Fanny, Desbois, Anne Claire, Comarmond, Cloé, Champtiaux, Nicolas, Toquet, Segolene, Ghembaza, Amine, Vieira, Matheus, Maalouf, Georgina, Boleto, Gonçalo, Ferfar, Yasmina, Charbonnier, Fanny, AGUILAR, Claire, ALBY-LAURENT, Fanny, ALYANAKIAN, Marie-Alexandra, BAKOUBOULA, Prissile, BROISSAND, Christine, BURGER, Carole, CAMPOS-VEGA, Clara, CHAVAROT, Nathalie, CHOUPEAUX, Laure, FOURNIER, Benjamin, GRANVILLE, Sophie, ISSORAT, Elodie, ROUZAUD, Claire, VIMPERE, Damien, Geri, Guillaume, Derridj, Nawal, Sguiouar, Naima, Meddah, Hakim, Djadel, Mourad, Chambrin-Lauvray, Helene, Duclos-Vallée, Jean-Charles, Saliba, Faouzi, Sacleux, Sophie-Caroline, Koumis, Ilias, Michot, Jean-Marie, Stoclin, Annabelle, Colomba, Emeline, Pommeret, Fanny, Willekens, Chistophe, Sakkal, Madona, Da Silva, Rosa, Dejean, Valérie, Mekid, Yasmina, Ben-Mabrouk, Ines, Pradon, Caroline, Drouard, Laurence, Camara-Clayette, Valérie, Morel, Alexandre, Garcia, Gilles, Mohebbi, Abolfazl, Berbour, Férial, Dehais, Mélanie, Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El Amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Razurel, Anaïs, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Hélène, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Clan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Servettaz, Amélie, Deslée, Gaetan, Wynckel, Alain, Benoit, Philippe, Marquis, Eric, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Hélène, Mourad, Jean-Jacques, Sacco, Emmanuelle, and Renet, Sophie

Published
2022
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128. Pertussis outbreak in neonates and young infants across Italy, January to May 2024: implications for vaccination strategies

Author

Poeta, Marco, primary, Moracas, Cristina, additional, Albano, Chiara, additional, Petrarca, Laura, additional, Maglione, Marco, additional, Pierri, Luca, additional, Carta, Maurizio, additional, Montaldo, Paolo, additional, Venturini, Elisabetta, additional, De Luca, Maia, additional, Buonsenso, Danilo, additional, Brambilla, Ilaria, additional, Giacomet, Vania, additional, Lo Vecchio, Andrea, additional, Bruzzese, Eugenia, additional, Midulla, Fabio, additional, Colomba, Claudia, additional, and Guarino, Alfredo, additional

Published
2024
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129. Exploring the tumor microenvironment (TME) in patients with mismatch repair-deficient (MMRd) endometrial cancer (EC) undergoing immune checkpoint inhibitor (ICI) therapy: Proteomic insights into immune resistance mechanisms.

Author

Grau Béjar, Juan Francisco, primary, Zeng, Qinghe, additional, Mehnert, Martin, additional, Colomba, Emeline, additional, Genestie, Catherine, additional, Le Formal, Audrey, additional, Edmond, Elodie, additional, Lachaud, Antoine Amaury, additional, Pautier, Patricia, additional, Michels, Judith, additional, Gouy, Sebastien, additional, Maulard, Amandine, additional, Yaniz, Elisa, additional, and Leary, Alexandra, additional

Published
2024
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130. Disparity in oncology therapy access and differences in clinical pathological features and outcomes in indigenous population lung cancer (LC): A retrospective study from Martinique.

Author

Moranton, Marlyne, primary, Colomba, Emeline, additional, Serag, Mounir, additional, Zouzou, Adel, additional, Boukadoum, Nassim, additional, Noly, Lauriane, additional, Lekhal-Bouamama, Amina, additional, Randriamiarisoa, Heriniaina Daddy, additional, Rakotonarivo, Jean-Marc, additional, Bougas, Stefanos, additional, Fard, Karim, additional, Masson, Soizic, additional, Drame, Moustapha, additional, Marlin, Régine, additional, Hustache-Castaing, Romain, additional, Aldea, Mihaela, additional, and Agossou, Moustapha, additional

Published
2024
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136. Analyzing breast cancer invasive disease event classification through explainable artificial intelligence

Author

Raffaella Massafra, Annarita Fanizzi, Nicola Amoroso, Samantha Bove, Maria Colomba Comes, Domenico Pomarico, Vittorio Didonna, Sergio Diotaiuti, Luisa Galati, Francesco Giotta, Daniele La Forgia, Agnese Latorre, Angela Lombardi, Annalisa Nardone, Maria Irene Pastena, Cosmo Maurizio Ressa, Lucia Rinaldi, Pasquale Tamborra, Alfredo Zito, Angelo Virgilio Paradiso, Roberto Bellotti, and Vito Lorusso

Subjects
invasive disease events, breast cancer, explainable AI, 10-year follow up, 5-year follow up, Medicine (General), R5-920
Abstract

IntroductionRecently, accurate machine learning and deep learning approaches have been dedicated to the investigation of breast cancer invasive disease events (IDEs), such as recurrence, contralateral and second cancers. However, such approaches are poorly interpretable.MethodsThus, we designed an Explainable Artificial Intelligence (XAI) framework to investigate IDEs within a cohort of 486 breast cancer patients enrolled at IRCCS Istituto Tumori “Giovanni Paolo II” in Bari, Italy. Using Shapley values, we determined the IDE driving features according to two periods, often adopted in clinical practice, of 5 and 10 years from the first tumor diagnosis.ResultsAge, tumor diameter, surgery type, and multiplicity are predominant within the 5-year frame, while therapy-related features, including hormone, chemotherapy schemes and lymphovascular invasion, dominate the 10-year IDE prediction. Estrogen Receptor (ER), proliferation marker Ki67 and metastatic lymph nodes affect both frames.DiscussionThus, our framework aims at shortening the distance between AI and clinical practice

Published
2023
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137. Urachal carcinoma: a large retrospective multicentric study from the French Genito-Urinary Tumor Group

Author

M. Guerin, C. Miran, E. Colomba, M. Cabart, T. Herrmann, S. Pericart, D. Maillet, Y. Neuzillet, A. Deleuze, E. Coquan, M. Laramas, C. Thibault, B. Abbar, B. Mesnard, D. Borchiellini, C. Dumont, E. Boughalem, JL. Deville, M. Cancel, C. Saldana, A. Khalil, G. Baciarello, A. Flechon, J. Walz, and G. Gravis

Subjects
retrospective, urachal cancer, multicentric, urachus, rare disease, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

IntroductionUrachal cancer (UrC) is a rare, non-urothelial malignancy. Its natural history and management are poorly understood. Although localized to the bladder dome, the most common histological subtype of UrC is adenocarcinoma. UrC develops from an embryonic remnant, and is frequently diagnosed in advanced stage with poor prognosis. The treatment is not standardized, and based only on case reports and small series. This large retrospective multicentric study was conducted by the French Genito-Urinary Tumor Group to gain a better understanding of UrC.Material and Methodsdata has been collected retrospectively on 97 patients treated at 22 French Cancer Centers between 1996 and 2020.ResultsThe median follow-up was 59 months (range 44-96). The median age at diagnosis was 53 years (range 20-86), 45% were females and 23% had tobacco exposure. For patients with localized disease (Mayo I-II, n=46) and with lymph-node invasion (Mayo III, n=13) median progression-free-survival (mPFS) was 31 months (95% CI: 20-67) and 7 months (95% CI: 6-not reached (NR)), and median overall survival (mOS) was 73 months (95% CI: 57-NR) and 22 months (95% CI: 21-NR) respectively. For 45 patients with Mayo I-III had secondary metastatic progression, and 20 patients were metastatic at diagnosis. Metastatic localization was peritoneal for 54% of patients. Most patients with localized tumor were treated with partial cystectomy, with mPFS of 20 months (95% CI: 14-49), and only 12 patients received adjuvant therapy. Metastatic patients (Mayo IV) had a mOS of 23 months (95% CI: 19-33) and 69% received a platin-fluorouracil combination treatment.ConclusionUrC is a rare tumor of the bladder where patients are younger with a higher number of females, and a lower tobacco exposure than in standard urothelial carcinoma. For localized tumor, partial cystectomy is recommended. The mOS and mPFS were low, notably for patients with lymph node invasion. For metastatic patients the prognosis is poor and standard therapy is not well-defined. Further clinical and biological knowledge are needed.

Published
2023
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138. A CT-based transfer learning approach to predict NSCLC recurrence: The added-value of peritumoral region.

Author

Samantha Bove, Annarita Fanizzi, Federico Fadda, Maria Colomba Comes, Annamaria Catino, Angelo Cirillo, Cristian Cristofaro, Michele Montrone, Annalisa Nardone, Pamela Pizzutilo, Antonio Tufaro, Domenico Galetta, and Raffaella Massafra

Subjects
Medicine, Science
Abstract

Non-small cell lung cancer (NSCLC) represents 85% of all new lung cancer diagnoses and presents a high recurrence rate after surgery. Thus, an accurate prediction of recurrence risk in NSCLC patients at diagnosis could be essential to designate risk patients to more aggressive medical treatments. In this manuscript, we apply a transfer learning approach to predict recurrence in NSCLC patients, exploiting only data acquired during its screening phase. Particularly, we used a public radiogenomic dataset of NSCLC patients having a primary tumor CT image and clinical information. Starting from the CT slice containing the tumor with maximum area, we considered three different dilatation sizes to identify three Regions of Interest (ROIs): CROP (without dilation), CROP 10 and CROP 20. Then, from each ROI, we extracted radiomic features by means of different pre-trained CNNs. The latter have been combined with clinical information; thus, we trained a Support Vector Machine classifier to predict the NSCLC recurrence. The classification performances of the devised models were finally evaluated on both the hold-out training and hold-out test sets, in which the original sample has been previously divided. The experimental results showed that the model obtained analyzing CROP 20 images, which are the ROIs containing more peritumoral area, achieved the best performances on both the hold-out training set, with an AUC of 0.73, an Accuracy of 0.61, a Sensitivity of 0.63, and a Specificity of 0.60, and on the hold-out test set, with an AUC value of 0.83, an Accuracy value of 0.79, a Sensitivity value of 0.80, and a Specificity value of 0.78. The proposed model represents a promising procedure for early predicting recurrence risk in NSCLC patients.

Published
2023
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140. Prolonged SARS-CoV-2 RNA virus shedding and lymphopenia are hallmarks of COVID-19 in cancer patients with poor prognosis

Author

Goubet, Anne-Gaëlle, Dubuisson, Agathe, Geraud, Arthur, Danlos, François-Xavier, Terrisse, Safae, Silva, Carolina Alves Costa, Drubay, Damien, Touri, Lea, Picard, Marion, Mazzenga, Marine, Silvin, Aymeric, Dunsmore, Garett, Haddad, Yacine, Pizzato, Eugenie, Ly, Pierre, Flament, Caroline, Melenotte, Cléa, Solary, Eric, Fontenay, Michaela, Garcia, Gabriel, Balleyguier, Corinne, Lassau, Nathalie, Maeurer, Markus, Grajeda-Iglesias, Claudia, Nirmalathasan, Nitharsshini, Aprahamian, Fanny, Durand, Sylvère, Kepp, Oliver, Ferrere, Gladys, Thelemaque, Cassandra, Lahmar, Imran, Fahrner, Jean-Eudes, Meziani, Lydia, Ahmed-Belkacem, Abdelhakim, Saïdani, Nadia, La Scola, Bernard, Raoult, Didier, Gentile, Stéphanie, Cortaredona, Sébastien, Ippolito, Giuseppe, Lelouvier, Benjamin, Roulet, Alain, Andre, Fabrice, Barlesi, Fabrice, Soria, Jean-Charles, Pradon, Caroline, Gallois, Emmanuelle, Pommeret, Fanny, Colomba, Emeline, Ginhoux, Florent, Kazandjian, Suzanne, Elkrief, Arielle, Routy, Bertrand, Miyara, Makoto, Gorochov, Guy, Deutsch, Eric, Albiges, Laurence, Stoclin, Annabelle, Gachot, Bertrand, Florin, Anne, Merad, Mansouria, Scotte, Florian, Assaad, Souad, Kroemer, Guido, Blay, Jean-Yves, Marabelle, Aurélien, Griscelli, Frank, Zitvogel, Laurence, and Derosa, Lisa

Published
2021
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141. Mucosal Relapse of Visceral Leishmaniasis in a Child with SARS-CoV-2 Infection

Author

Claudia Colomba, Giovanni Boncori, Chiara Albano, Valeria Garbo, Sara Bagarello, Anna Condemi, Salvatore Giordano, and Antonio Cascio

Subjects
visceral, leishmaniasis, mucosal, relapse, pediatric, Medicine
Abstract

Leishmaniasis is a vector-borne disease caused by protozoan parasites of the genus Leishmania and is transmitted through the bite of infected female sandflies. In the Mediterranean region, visceral leishmaniasis is caused by Leishmania. infantum, and it is usually responsible for symptoms such as fever, pancytopenia and enlargement of the liver and spleen. Relapse is rare in immunocompetent patients as much as the mucous involvement. We present a rare case of mucosal relapse of visceral leishmaniasis in a child with SARS-CoV-2 infection and perform an extensive review of the literature about leishmaniasis relapses in children. Atypical mucosal involvement during Leishmaniasis relapse is an eventuality in pediatric patients. Clinical follow-up and periodic PCR tests must be considered essential for the early recognition and treatment of an eventual relapse.

Published
2023
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144. Impact of COVID-19 on healthcare organisation and cancer outcomes

Author

Bardet, Aurelie, Fraslin, Alderic M., Marghadi, Jamila, Borget, Isabelle, Faron, Matthieu, Honoré, Charles, Delaloge, Suzette, Albiges, Laurence, Planchard, David, Ducreux, Michel, Hadoux, Julien, Colomba, Emeline, Robert, Caroline, Bouhir, Samia, Massard, Christophe, Micol, Jean-Baptiste, Ter-Minassian, Lucile, Michiels, Stefan, Auperin, Anne, Barlesi, Fabrice, and Bonastre, Julia

Published
2021
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145. Response to systemic therapy in fumarate hydratase–deficient renal cell carcinoma

Author

Carril-Ajuria, Lucia, Colomba, Emeline, Cerbone, Luigi, Romero-Ferreiro, Carmen, Crouzet, Laurence, Laguerre, Brigitte, Thibault, Constance, Vicier, Cécile, de Velasco, Guillermo, Fléchon, Aude, Saldana, Carolina, Benusiglio, Patrick R., Bressac-de Paillerets, Brigitte, Guillaud-Bataille, Marine, Gaignard, Pauline, Scoazec, Jean-Yves, Richard, Stéphane, Caron, Olivier, Escudier, Bernard, and Albiges, Laurence

Published
2021
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147. Corticosteroids in patients hospitalized for COVID-19 pneumonia who require oxygen: observational comparative study using routine care data

Author

Lescure, François-Xavier, Tran, Viet-Thi, Mahévas, Matthieu, Bani-Sadr, Firouze, Robineau, Olivier, Perpoint, Thomas, Perrodeau, Elodie, Gallay, Laure, Ravaud, Philippe, Goehringer, François, Ismaël, Sophie, Laouénan, Cédric, Soulier, Jennifer, Puéchal, Oriane, D’Ortenzio, Eric, Yazdanpanah, Yazdan, Maulin, Laurence, Martinez, Stéphanie, Sanderink, Diane, Fialaire, Pascale, Ansart, Séverine, Perez, Lucas, Destrem, Anne - Laure, Moulin, Chloé, Gicquel, Pascal, Rivière, Frédéric, Martinot, Martin, Zadeh, Mahsa Mohseni, Chroboczek, Tomasz, Belval, Thibaut Challan, Piroth, Lionel, Sixt, Thibault, Moretto, Florian, Cabié, André, Pasquier, Jérémie, Cabras, Ornella, Morrier, Marine, Reuter, Jean, Henin, Thomas, Braquet, Pierre, Desmurs-Clavel, Helene, Hot, Arnaud, Bienvenu, Boris, Asselate, Belkacem, Vignier, Nicolas, Nguala, Steve, Diamantis, Sylvain, Frémont, Guillemette, Nivose, Pierre Louis, Thiébaut, Mathilde, Lefevre, Benjamin, Auge, Hélène, le Turnier, Paul, Benkalfate, Naila, Grossi, Olivier, Pineau, Samuel, Demonchy, Elisa, Merindol, Julie, Durand, Claire, Tieulié, Nathalie, Queyrel, Viviane, Laureillard, Didier, Loubet, Paul, Greffe, Ségolène, Dournon, Nathalie, Kassim, Youssouf Mohamed, Gourjault, Cyrille, Lahens, Alexandre, Legendre, Paul, Morbieu, Caroline, Mahevas, Matthieu, Melica, Giovanna, Levièvre, Jean-Daniel, Schlemmer, Frédéric, Tunesi, Simone, Leblanc, Claire, Bourgarit-Durand, Anne, Bleibtreu, Alexandre, Tebano, Gianpiero, Pacanowski, Jérôme, Zabbe, Jean-Benoit, Devaux, Mathilde, Bellec, Laurent, Gosset-Woimant, Marine, Lambert, Céleste, Hentzien, Maxime, Servettaz, Amélie, Alexandre, Kevin, Etienne, Manuel, Leguillon, Romain, Dollat, Marion, Lefrancois, Rémi, Pouvaret, Anne, Ruch, Yvon, Dieudonné, Yannick, Martin-Blondel, Guillaume, Boumaza, Xavier, Lafaurie, Margaux, Tetart, Macha, Lemaignen, Adrien, Ferreira-Maldent, Nicole, Duréault, Amélie, Gousseff, Marie, Chantepie, Claire, Bisio, Francesca, Pommeret, Fanny, Blamble, Emeline Colomba, and Somohano, Claire Ara

Published
2021
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148. Effect of anakinra versus usual care in adults in hospital with COVID-19 and mild-to-moderate pneumonia (CORIMUNO-ANA-1): a randomised controlled trial

Author

Tharaux, Pierre-Louis, Pialoux, Gilles, Pavot, Arthur, Mariette, Xavier, Hermine, Olivier, Resche-Rigon, Matthieu, Porcher, Raphael, Ravaud, Philippe, Bureau, Serge, Dougados, Maxime, Tibi, Annick, Azoulay, Elie, Cadranel, Jacques, Emmerich, Joseph, Fartoukh, Muriel, Guidet, Bertrand, Humbert, Marc, Lacombe, Karine, Mahevas, Matthieu, Pene, Frédéric, Pourchet-Martinez, Valérie, Schlemmer, Frédéric, Yazdanpanah, Yazdan, Baron, Gabriel, Perrodeau, Elodie, Vanhoye, Damien, Kedzia, Cécile, Demerville, Lauren, Gysembergh-Houal, Anne, Bourgoin, Alexandre, Dalibey, Sarah, Raked, Nabil, Mameri, Lakhdar, Alary, Stéphanie, Hamiria, Samir, Bariz, Thinhinane, Semri, Hala, Hai, Dhiaa Meriem, Benafla, Moustafa, Belloul, Mohamed, Vauboin, Pernelle, Flamand, Saskia, Pacheco, Claire, Walter-Petrich, Anouk, Stan, Emilia, Benarab, Souad, Nyanou, Corine, Montlahuc, Claire, Biard, Lucie, Charreteur, Robin, Dupré, Celine, Cardet, Kévin, Lehmann, Blandine, Baghli, Kamyl, Madelaine, Claire, D'Ortenzio, Eric, Puéchal, Oriane, Semaille, Caroline, Savale, Laurent, Harrois, Anatole, Figueiredo, Samy, Duranteau, Jacques, Anguel, Nadia, Monnet, Xavier, Richard, Christian, Teboul, Jean-Louis, Durand, Philippe, Tissieres, Pierre, Jevnikar, Mitja, Montani, David, Bulifon, Sophie, Jaïs, Xavier, Sitbon, Olivier, Pavy, Stéphan, Noel, Nicolas, Lambotte, Olivier, Escaut, Lelia, Jauréguiberry, Stéphane, Baudry, Elodie, Verny, Christiane, Noaillon, Mathilde, Lefèvre, Edouard, Zaidan, Mohamad, Le Tiec, Clotilde Le Tiec, Verstuyft, Céline Verstuyft, Roques, Anne-Marie, Grimaldi, Lamiae, Molinari, Domitille, Leprun, Gaël, Fourreau, Alain, Cylly, Laurent, Virlouvet, Myriam, Meftali, Ramdane, Fabre, Solène, Licois, Marion, Mamoune, Asmaa, Boudali, Yacine, Georgin-Lavialle, Sophie, Senet, Patricia, Soria, Angèle, Parrot, Antoine, François, Hélène, Rozensztajn, Nathalie, Blin, Emmanuelle, Choinier, Pascaline, Camuset, Juliette, Rech, Jean-Simon, Canellas, Antony, Rolland-Debord, Camille, Lemarié, Nadège, Belaube, Nicolas, Nadal, Marine, Siguier, Martin, Petit-Hoang, Camille, Chas, Julie, Drouet, Elodie, Lemoine, Matthieu, Phibel, Audrey, Aunay, Lucie, Bertrand, Eliane, Ravato, Sylviane, Vayssettes, Marie, Adda, Anne, Wilpotte, Celine, Thibaut, Pélagie, Fillon, Julie, Debrix, Isabelle, Fellahi, Soraya, Bastard, Jean-Philippe, Lefèvre, Guillaume, Fallet, Vincent, Gottenberg, Jacques-Eric, Hansmann, Yves, Andres, Emmanuel, Bayer, Sophie, Becker, Guillaume, Blanc, Frédéric, Brin, Stéphane, Castelain, Vincent, Chatelus, Emmanuel, Chatron, Eva, Collange, Olivier, Danion, François, De Blay, Frédéric, Demonsant, Eric, Diemunsch, Pierre, Diemunsch, Sophie, Felten, Renaud, Goichot, Bernard, Greigert, Valentin, Guffroy, Aurélien, Heger, Bob, Hutt, Anne, Kaeuffer, Charlotte, Kassegne, Loic, Korganow, Anne Sophie, Le Borgne, Pierrick, Lefebvre, Nicolas, Martin, Tristan, Mertes, Paul Michel, Metzger, Catherine, Meyer, Nicolas, Nisand, Gabriel, Noll, Eric, Oberlin, Mathieu, Ohlmann-Caillard, Sophie, Poindron, Vincent, Pottecher, Julien, Ruch, Yvon, Sublon, Cédric, Tayebi, Hakim, Weill, François, Mekinian, Arsène, Chopin, Dorothée, Fain, Olivier, Garnier, Marc, Krause le Garrec, Jessica, Morgand, Marjolaine, Pacanowski, Jerome, Urbina, Tomas, McAvoy, Chloe, Pereira, Maria, Aratus, Gladys, Berard, Laurence, Simon, Tabassome, Daguenel-Nguyen, Anne, Antignac, Marie, Leplay, Céline, Arlet, Jean-Benoit, Diehl, Jean-Luc, Bellenfant, Florence, Blanchard, Anne, Buffet, Alexandre, Cholley, Bernard, Fayol, Antoine, Flamarion, Edouard, Godier, Anne, Gorget, Thomas, Hamada, Sophie-Rym, Hauw-Berlemont, Caroline, Hulot, Jean-Sébastien, Lebeaux, David, Livrozet, Marine, Michon, Adrien, Neuschwander, Arthur, Penet, Marie-Aude, Planquette, Benjamin, Ranque, Brigitte, Sanchez, Olivier, Volle, Geoffroy, Briois, Sandrine, Cornic, Mathias, Elisee, Virginie, Jesuthasan, Denis, Djadi-Prat, Juliette, Jouany, Pauline, Junquera, Ramon, Henriques, Mickael, Kebir, Amina, Lehir, Isabelle, Meunier, Jeanne, Patin, Florence, Paquet, Valérie, Tréhan, Anne, Vigna, Véronique, Sabatier, Brigitte, Bergerot, Damien, Jouve, Charléne, Knosp, Camille, Lenoir, Olivia, Mahtal, Nassim, Resmini, Léa, Lescure, F-Xavier, Ghosn, Jade, BACHELARD, Antoine, BIRONNE, Timothee, BORIE, Raphael, BOUNHIOL, Agathe, BOUSSARD, Catherine, CHAUFFiER, Jeanne, CHALAL, Solaya, CHALAL, Lynda, CHANSOMBAT, Malikhone, CRESPIN, Paul, CRESTANI, Bruno, DACONCEICAO, Olivia, DECONINCK, Laurene, DIEUDE, Philippe, DOSSIER, Antoine, DUBERT, Marie, DUCROCQ, Greggory, FUENTES, Axelle, GERVAIS, Anne, GILBERT, Marie, ISERNIA, Valentina, ISMAEL, Sophie, JOLY, Veronique, JULIA, Zelie, LARIVEN, Sylvie, LE GAC, Sylvie, LE PLUART, Diane, LOUNI, Francoise, NDIAYE, Awa, PAPO, Thomas, PARISEY, Marion, PHUNG, Bao, POURBAIX, Annabelle, RACHLINE, Anne, RIOUX, Christophe, SAUTEREAU, Aurelie, STEG, Gabriel, TARHINI, Hassan, VALAYER, Simon, VALLOIS, Dorothee, VERMES, Paul, VOLPE, Thomas, Nguyen, Yann, Honsel, Vasco, Weiss, Emmanuel, Codorniu, Anaïs, Zarrouk, Virginie, De Lastours, Victoire, Uzzan, Matthieu, Olivier, Olivier, Rossi, Geoffrey, Gamany, Naura, Rahli, Roza, Louis, Zeina, Boutboul, David, Galicier, Lionel, Amara, Yaël, Archer, Gabrielle, Benattia, Amira, Bergeron, Anne, Bondeelle, Louise, De Castro, Nathalie, Clément, Melissa, Darmont, Michaël, Denis, Blandine, Dupin, Clairelyne, Feredj, Elsa, Feyeux, Delphine, Joseph, Adrien, Lengliné, Etienne, Le Guen, Pierre, Liégeon, Geoffroy, Lorillon, Gwenaël, Mabrouki, Asmaa, Mariotte, Eric, Martin de Frémont, Grégoire, Mirouse, Adrien, Molina, Jean-Michel, Peffault de Latour, Régis, Oksenhendler, Eric, Saussereau, Julien, Tazi, Abdellatif, Tudesq, Jean-Jacques, Zafrani, Lara, Brindele, Isabelle, Bugnet, Emmanuelle, Celli Lebras, Karine, Chabert, Julien, Djaghout, Lalia, Fauvaux, Catherine, Jegu, Anne Lise, Kozaliewicz, Ewa, Meunier, Martine, Tremorin, Marie-Thérèse, Davoine, Claire, Madeleine, Isabelle, Caillat-Zucman, Sophie, Delaugerre, Constance, Morin, Florence, SENE, Damien, BURLACU, Ruxandra, CHOUSTERMAN, Benjamin, MEGARBANE, Bruno, RICHETTE, Pascal, RIVELINE, Jean-Pierre, FRAZIER, Aline, VICAUT, Eric, BERTON, Laure, HADJAM, Tassadit, VASQUEZ-IBARRA, Miguel Alejandro, JOURDAINE, Clément, JACOB, Aude, SMATI, Julie, RENAUD, Stéphane, MANIVET, Philippe, PERNIN, Claire, SUAREZ, Lydia, Semerano, Luca, ABAD, Sebastien, Benainous, Ruben, Bloch Queyrat, Coralie, Bonnet, Nicolas, Brahmi, Sabrina, Cailhol, johann, Cohen, Yves, Comparon, Celine, Cordel, Hugues, Dhote, Robin, Dournon, Nathalie, Duchemann, Boris, Ebstein, Nathan, Giroux-Leprieur, Benedicte, Goupil de Bouille, Jeanne, Jacolot, Anne, Nunes, Hilario, Oziel, Johanna, Rathouin, Vanessa, Rigal, Marthe, Roulot, Dominique, Tantet, Claire, Uzunhan, Yurdagul, COSTEDOAT-CHALUMEAU, Nathalie, Ait Hamou, Zakaria, Benghanem, Sarah, BLANCHE, Philippe, CANOUI, Etienne, CARLIER, Nicolas, CHAIGNE, Benjamin, CONTEJEAN, Adrien, DUNOGUE, Bertrand, DUPLAND, Pierre, DUREL - MAURISSE, Aurélie, GAUZIT, Remy, JAUBERT, Paul, Joumaa, Hassan, Jozwiak, Mathieu, KERNEIS, Solen, LACHATRE, Marie, Lafoeste, Hélène, LEGENDRE, Paul, LUONG NGUYEN, Liem Binh, MAREY, Jonathan, MORBIEU, Caroline, MOUTHON, Luc, NGUYEN, Lee, Palmieri, Lola-Jade, REGENT, Alexis, SZWEBEL, Tali-Anne, TERRIER, Benjamin, GUERIN, Corinne, ZERBIT, Jérémie, CHEREF, Kahina, CHITOUR, Kamil, CISSE, Mamadou Salif, CLARKE, Ada, CLAVERE, Gaelle, DUSANTER, Isabelle, GAUDEFROY, Caroline, JALLOULI, Moez, KOLTA, Sami, LE BOURLOUT, Catherine, MARIN, Nathalie, MENAGE, Nathalie, MOORES, Alexandre, PEIGNEY, Isabelle, PIERRON, Cédric, SALEH-MGHIR, Samira, VALLET, Mathilde, MICHEL, Marc, MELICA, Giovanna, LELIEVRE, Jean-Daniel, FOIS, Elena, LIM, Pascal, MATIGNON, Marie, GUILLAUD, Constance, THIEMELE, Alaki, SCHMITZ, David, BOUHRIS, Marion, BELAZOUZ, Syllia, LANGUILLE, Laetitia, MEKONTSO-DESSAPS, Armand, SADAOUI, Thiziri, Mayaux, Julien, Cacoub, Patrice, Corvol, Jean-Christophe, Louapre, Céline, Sambin, Sara, Mariani, Louise-Laure, Karachi, Carine, Tubach, Florence, Estellat, Candice, Gimeno, Linda, Martin, Karine, Bah, Aïcha, Keo, Vixra, Ouamri, Sabrine, Messaoudi, Yasmine, Yelles, Nessima, Faye, Pierre, Cavelot, Sébastien, Larcheveque, Cecile, Annonay, Laurence, Benhida, Jaouad, Zahrate-Ghoul, Aida, Hammal, Soumeya, Belilita, Ridha, Lecronier, Marie, Beurton, Alexandra, Haudebourg, Luc, Deleris, Robin, Le Marec, Julien, Virolle, Sara, Nemlaghi, Safaa, Bureau, Côme, Mora, Pierre, De Sarcus, Martin, Clovet, Olivier, Duceau, Baptiste, Grisot, Paul Henri, Pari, Marie hélène, Arzoine, Jérémy, Clarac, Ulrich, Faure, Morgane, Delemazure, Julie, Decavele, Maxence, Morawiec, Elise, Demoule, Alexandre, Dres, Martin, Vautier, Mathieu, Allenbach, Yves, Benveniste, Olivier, Leroux, Gaelle, Rigolet, Aude, Guillaume-Jugnot, Perrine, Domont, Fanny, Desbois, Anne Claire, Comarmond, Cloé, Champtiaux, Nicolas, Toquet, Segolene, Ghembaza, Amine, Vieira, Matheus, Maalouf, Georgina, Boleto, Gonçalo, Ferfar, Yasmina, Charbonnier, Fanny, AGUILAR, Claire, ALBY-LAURENT, Fanny, ALYANAKIAN, Marie-Alexandra, BAKOUBOULA, Prissile, BROISSAND, Christine, BURGER, Carole, CAMPOS-VEGA, Clara, CHAVAROT, Nathalie, CHOUPEAUX, Laure, FOURNIER, Benjamin, GRANVILLE, Sophie, ISSORAT, Elodie, ROUZAUD, Claire, VIMPERE, Damien, Geri, Guillaume, Derridj, Nawal, Sguiouar, Naima, Meddah, Hakim, Djadel, Mourad, Chambrin-Lauvray, Helene, Duclos-Vallée, Jean-Charles, Saliba, Faouzi, Sacleux, Sophie-Caroline, Koumis, Ilias, Michot, Jean-Marie, Stoclin, Annabelle, Colomba, Emeline, Pommeret, Fanny, Willekens, Chistophe, Sakkal, Madona, Da Silva, Rosa, Dejean, Valérie, Mekid, Yasmina, Ben-Mabrouk, Ines, Pradon, Caroline, Drouard, Laurence, Camara-Clayette, Valérie, Morel, Alexandre, Garcia, Gilles, Mohebbi, Abolfazl, Berbour, Férial, Dehais, Mélanie, Pouliquen, Anne-Lise, Klasen, Alison, Soyez-Herkert, Loren, London, Jonathan, Keroumi, Younes, Guillot, Emmanuelle, Grailles, Guillaume, El Amine, Younes, Defrancq, Fanny, Fodil, Hanane, Bouras, Chaouki, Dautel, Dominique, Gambier, Nicolas, Dieye, Thierno, Razurel, Anaïs, Bienvenu, Boris, Lancon, Victor, Lecomte, Laurence, Beziriganyan, Kristina, Asselate, Belkacem, Allanic, Laure, Kiouris, Elena, Legros, Marie-Hélène, Lemagner, Christine, Martel, Pascal, Provitolo, Vincent, Ackermann, Félix, Le Marchand, Mathilde, Clan Hew Wai, Aurélie, Fremont, Dimitri, Coupez, Elisabeth, Adda, Mireille, Duée, Frédéric, Bernard, Lise, Gros, Antoine, Henry, Estelle, Courtin, Claire, Pattyn, Anne, Guinot, Pierre-Grégoire, Bardou, Marc, Maurer, Agnes, Jambon, Julie, Cransac, Amélie, Pernot, Corinne, Mourvillier, Bruno, Servettaz, Amélie, Deslée, Gaetan, Wynckel, Alain, Benoit, Philippe, Marquis, Eric, Roux, Damien, Gernez, Coralie, Yelnik, Cécile, Poissy, Julien, Nizard, Mandy, Denies, Fanette, Gros, Hélène, Mourad, Jean-Jacques, Sacco, Emmanuelle, and Renet, Sophie

Published
2021
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149. Corrigendum: Transfer learning approach based on computed tomography images for predicting late xerostomia after radiotherapy in patients with oropharyngeal cancer

Author

Annarita Fanizzi, Giovanni Scognamillo, Alessandra Nestola, Santa Bambace, Samantha Bove, Maria Colomba Comes, Cristian Cristofaro, Vittorio Didonna, Alessia Di Rito, Angelo Errico, Loredana Palermo, Pasquale Tamborra, Michele Troiano, Salvatore Parisi, Rossella Villani, Alfredo Zito, Marco Lioce, and Raffaella Massafra

Subjects
deep learning, xerostomia, oropharyngeal cancer, CT images, CNN-convolutional neural network, Medicine (General), R5-920
Published
2022
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150. Chemical composition, antioxidant and anti-inflammatory properties of Monarda didyma L. essential oil

Author

Daniele Fraternale, Hanh Dufat, Maria Cristina Albertini, Chouaha Bouzidi, Rossella D’Adderio, Sofia Coppari, Barbara Di Giacomo, Davide Melandri, Seeram Ramakrishna, and Mariastella Colomba

Subjects
Scarlet beebalm, Monoterpenes, Monoterpenoids, LPS, microRNAs, TLR-4, Medicine, Biology (General), QH301-705.5
Abstract

In the present study, Monarda didyma L. essential oil (isolated from the flowering aerial parts of the plant) was examined to characterize its chemotype and to evaluate, in addition to the quali-quantitative chemical analysis, the associated antioxidant and anti-inflammatory activities. The plants were grown in central Italy, Urbino (PU), Marche region. Different analyses (TLC, GC-FID, GC-MS and 1H-NMR) allowed the identification of twenty compounds among which carvacrol, p-cymene and thymol were the most abundant. On this basis, the chemotype examined in the present study was indicated as Monarda didyma ct. carvacrol. The antioxidant effect was assessed by DPPH assay. Moreover, this chemotype was investigated for the anti-inflammatory effect in an in vitro setting (i.e., LPS-stimulated U937 cells). The decreased expression of pro-inflammatory cytokine IL-6 and the increased expression of miR-146a are suggestive of the involvement of the Toll-like receptor-4 signaling pathway. Although further studies are needed to better investigate the action mechanism/s underlying the results observed in the experimental setting, our findings show that M. didyma essential oil is rich in bioactive compounds (mainly aromatic monoterpenes and phenolic monoterpenes) which are most likely responsible for its beneficial effect.

Published
2022
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