7,564 results on '"Cohen E."'
Search Results
102. Ionization electron signal processing in single phase LArTPCs. Part II. Data/simulation comparison and performance in MicroBooNE
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Adams, C, An, R, Anthony, J, Asaadi, J, Auger, M, Balasubramanian, S, Baller, B, Barnes, C, Barr, G, Bass, M, Bay, F, Bhat, A, Bhattacharya, K, Bishai, M, Blake, A, Bolton, T, Camilleri, L, Caratelli, D, Terrazas, IC, Carr, R, Fernandez, RC, Cavanna, F, Cerati, G, Chen, H, Chen, Y, Church, E, Cianci, D, Cohen, E, Collin, GH, Conrad, JM, Convery, M, Cooper-Troendle, L, Crespo-Anadón, JI, Tutto, MD, Devitt, D, Diaz, A, Dolce, M, Dytman, S, Eberly, B, Ereditato, A, Sanchez, LE, Esquivel, J, Evans, JJ, Fadeeva, AA, Fleming, BT, Foreman, W, Furmanski, AP, Garcia-Gamez, D, Garvey, GT, Genty, V, Goeldi, D, Gollapinni, S, Gramellini, E, Greenlee, H, Grosso, R, Guenette, R, Guzowski, P, Hackenburg, A, Hamilton, P, Hen, O, Hewes, J, Hill, C, Ho, J, Horton-Smith, GA, Hourlier, A, Huang, EC, James, C, De Vries, JJ, Jiang, L, Johnson, RA, Joshi, J, Jostlein, H, Jwa, YJ, Kaleko, D, Karagiorgi, G, Ketchum, W, Kirby, B, Kirby, M, Kobilarcik, T, Kreslo, I, Li, Y, Lister, A, Littlejohn, BR, Lockwitz, S, Lorca, D, Louis, WC, Luethi, M, Lundberg, B, Luo, X, Marchionni, A, Marcocci, S, Mariani, C, Marshall, J, Caicedo, DAM, Mastbaum, A, Meddage, V, Mettler, T, Miceli, T, Mills, GB, and Mogan, A
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Neutrino detectors ,Performance of High Energy Physics Detectors ,Data processing methods ,Time projection Chambers ,physics.ins-det ,hep-ex ,nucl-ex ,Nuclear & Particles Physics ,Physical Sciences ,Engineering - Abstract
The single-phase liquid argon time projection chamber (LArTPC) provides a large amount of detailed information in the form of fine-grained drifted ionization charge from particle traces. To fully utilize this information, the deposited charge must be accurately extracted from the raw digitized waveforms via a robust signal processing chain. Enabled by the ultra-low noise levels associated with cryogenic electronics in the MicroBooNE detector, the precise extraction of ionization charge from the induction wire planes in a single-phase LArTPC is qualitatively demonstrated on MicroBooNE data with event display images, and quantitatively demonstrated via waveform-level and track-level metrics. Improved performance of induction plane calorimetry is demonstrated through the agreement of extracted ionization charge measurements across different wire planes for various event topologies. In addition to the comprehensive waveform-level comparison of data and simulation, a calibration of the cryogenic electronics response is presented and solutions to various MicroBooNE-specific TPC issues are discussed. This work presents an important improvement in LArTPC signal processing, the foundation of reconstruction and therefore physics analyses in MicroBooNE.
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- 2018
103. Ionization electron signal processing in single phase LArTPCs. Part I. Algorithm Description and quantitative evaluation with MicroBooNE simulation
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Adams, C, An, R, Anthony, J, Asaadi, J, Auger, M, Bagby, L, Balasubramanian, S, Baller, B, Barnes, C, Barr, G, Bass, M, Bay, F, Bhat, A, Bhattacharya, K, Bishai, M, Blake, A, Bolton, T, Camilleri, L, Caratelli, D, Fernandez, RC, Cavanna, F, Cerati, G, Chen, H, Chen, Y, Church, E, Cianci, D, Cohen, E, Collin, GH, Conrad, JM, Convery, M, Cooper-Troendle, L, Crespo-Anadón, JI, Tutto, MD, Devitt, D, Diaz, A, Dytman, S, Eberly, B, Ereditato, A, Sanchez, LE, Esquivel, J, Evans, JJ, Fadeeva, AA, Fleming, BT, Foreman, W, Furmanski, AP, Garcia-Gamez, D, Garvey, GT, Genty, V, Goeldi, D, Gollapinni, S, Gramellini, E, Greenlee, H, Grosso, R, Guenette, R, Guzowski, P, Hackenburg, A, Hamilton, P, Hen, O, Hewes, J, Hill, C, Ho, J, Horton-Smith, GA, Hourlier, A, Huang, EC, James, C, De Vries, JJ, Jiang, L, Johnson, RA, Joshi, J, Jostlein, H, Jwa, YJ, Kaleko, D, Karagiorgi, G, Ketchum, W, Kirby, B, Kirby, M, Kobilarcik, T, Kreslo, I, Li, Y, Lister, A, Littlejohn, BR, Lockwitz, S, Lorca, D, Louis, WC, Luethi, M, Lundberg, B, Luo, X, Marchionni, A, Marcocci, S, Mariani, C, Marshall, J, Caicedo, DAM, Mastbaum, A, Meddage, V, Miceli, T, Mills, GB, Mogan, A, Moon, J, Mooney, M, and Moore, CD
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Data processing methods ,Neutrino detectors ,Time projection chambers ,physics.ins-det ,hep-ex ,nucl-ex ,Nuclear & Particles Physics ,Physical Sciences ,Engineering - Abstract
We describe the concept and procedure of drifted-charge extraction developed in the MicroBooNE experiment, a single-phase liquid argon time projection chamber (LArTPC). This technique converts the raw digitized TPC waveform to the number of ionization electrons passing through a wire plane at a given time. A robust recovery of the number of ionization electrons from both induction and collection anode wire planes will augment the 3D reconstruction, and is particularly important for tomographic reconstruction algorithms. A number of building blocks of the overall procedure are described. The performance of the signal processing is quantitatively evaluated by comparing extracted charge with the true charge through a detailed TPC detector simulation taking into account position-dependent induced current inside a single wire region and across multiple wires. Some areas for further improvement of the performance of the charge extraction procedure are also discussed.
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- 2018
104. The Pandora multi-algorithm approach to automated pattern recognition of cosmic-ray muon and neutrino events in the MicroBooNE detector.
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Acciarri, R, Adams, C, An, R, Anthony, J, Asaadi, J, Auger, M, Bagby, L, Balasubramanian, S, Baller, B, Barnes, C, Barr, G, Bass, M, Bay, F, Bishai, M, Blake, A, Bolton, T, Camilleri, L, Caratelli, D, Carls, B, Castillo Fernandez, R, Cavanna, F, Chen, H, Church, E, Cianci, D, Cohen, E, Collin, GH, Conrad, JM, Convery, M, Crespo-Anadón, JI, Del Tutto, M, Devitt, D, Dytman, S, Eberly, B, Ereditato, A, Escudero Sanchez, L, Esquivel, J, Fadeeva, AA, Fleming, BT, Foreman, W, Furmanski, AP, Garcia-Gamez, D, Garvey, GT, Genty, V, Goeldi, D, Gollapinni, S, Graf, N, Gramellini, E, Greenlee, H, Grosso, R, Guenette, R, Hackenburg, A, Hamilton, P, Hen, O, Hewes, J, Hill, C, Ho, J, Horton-Smith, G, Hourlier, A, Huang, E-C, James, C, Jan de Vries, J, Jen, C-M, Jiang, L, Johnson, RA, Joshi, J, Jostlein, H, Kaleko, D, Karagiorgi, G, Ketchum, W, Kirby, B, Kirby, M, Kobilarcik, T, Kreslo, I, Laube, A, Li, Y, Lister, A, Littlejohn, BR, Lockwitz, S, Lorca, D, Louis, WC, Luethi, M, Lundberg, B, Luo, X, Marchionni, A, Mariani, C, Marshall, J, Martinez Caicedo, DA, Meddage, V, Miceli, T, Mills, GB, Moon, J, Mooney, M, Moore, CD, Mousseau, J, Murrells, R, Naples, D, Nienaber, P, Nowak, J, Palamara, O, and Paolone, V
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hep-ex ,physics.data-an ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics ,Quantum Physics ,Nuclear & Particles Physics ,Atomic ,Molecular ,Nuclear ,Particle and Plasma Physics - Abstract
The development and operation of liquid-argon time-projection chambers for neutrino physics has created a need for new approaches to pattern recognition in order to fully exploit the imaging capabilities offered by this technology. Whereas the human brain can excel at identifying features in the recorded events, it is a significant challenge to develop an automated, algorithmic solution. The Pandora Software Development Kit provides functionality to aid the design and implementation of pattern-recognition algorithms. It promotes the use of a multi-algorithm approach to pattern recognition, in which individual algorithms each address a specific task in a particular topology. Many tens of algorithms then carefully build up a picture of the event and, together, provide a robust automated pattern-recognition solution. This paper describes details of the chain of over one hundred Pandora algorithms and tools used to reconstruct cosmic-ray muon and neutrino events in the MicroBooNE detector. Metrics that assess the current pattern-recognition performance are presented for simulated MicroBooNE events, using a selection of final-state event topologies.
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- 2018
105. Measurement of cosmic-ray reconstruction efficiencies in the MicroBooNE LArTPC using a small external cosmic-ray counter
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Acciarri, R, Adams, C, An, R, Anthony, J, Asaadi, J, Auger, M, Bagby, L, Balasubramanian, S, Baller, B, Barnes, C, Barr, G, Bass, M, Bay, F, Bishai, M, Blake, A, Bolton, T, Camilleri, L, Caratelli, D, Carls, B, Castillo Fernandez, R, Cavanna, F, Chen, H, Church, E, Cianci, D, Cohen, E, Collin, GH, Conrad, JM, Convery, M, Crespo-Anadón, JI, Del Tutto, M, Devitt, D, Dytman, S, Eberly, B, Ereditato, A, Escudero Sanchez, L, Esquivel, J, Fadeeva, AA, Fleming, BT, Foreman, W, Furmanski, AP, Garcia-Gamez, D, Garvey, GT, Genty, V, Goeldi, D, Gollapinni, S, Graf, N, Gramellini, E, Greenlee, H, Grosso, R, Guenette, R, Hackenburg, A, Hamilton, P, Hen, O, Hewes, J, Hill, C, Ho, J, Horton-Smith, G, Hourlier, A, Huang, EC, James, C, Jan De Vries, J, Jen, CM, Jiang, L, Johnson, RA, Joshi, J, Jostlein, H, Kaleko, D, Kalousis, LN, Karagiorgi, G, Ketchum, W, Kirby, B, Kirby, M, Kobilarcik, T, Kreslo, I, Lange, G, Laube, A, Li, Y, Lister, A, Littlejohn, BR, Lockwitz, S, Lorca, D, Louis, WC, Luethi, M, Lundberg, B, Luo, X, Marchionni, A, Mariani, C, Marshall, J, Martinez Caicedo, DA, Meddage, V, Miceli, T, Mills, GB, Moon, J, Mooney, M, Moore, CD, Mousseau, J, Murrells, R, Naples, D, Nienaber, P, and Nowak, J
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Performance of High Energy Physics Detectors ,Time projection chambers ,Data reduction methods ,Neutrino detectors ,hep-ex ,Nuclear & Particles Physics ,Physical Sciences ,Engineering - Abstract
The MicroBooNE detector is a liquid argon time projection chamber at Fermilab designed to study short-baseline neutrino oscillations and neutrino-argon interaction cross-section. Due to its location near the surface, a good understanding of cosmic muons as a source of backgrounds is of fundamental importance for the experiment. We present a method of using an external 0.5 m (L) × 0.5 m (W) muon counter stack, installed above the main detector, to determine the cosmic-ray reconstruction efficiency in MicroBooNE. Data are acquired with this external muon counter stack placed in three different positions, corresponding to cosmic rays intersecting different parts of the detector. The data reconstruction efficiency of tracks in the detector is found to be ϵdata=(97.1±0.1 (stat) ± 1.4 (sys))%, in good agreement with the Monte Carlo reconstruction efficiency ϵMC = (97.4±0.1)%. This analysis represents a small-scale demonstration of the method that can be used with future data coming from a recently installed cosmic-ray tagger system, which will be able to tag ≈80% of the cosmic rays passing through the MicroBooNE detector.
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- 2017
106. Retrospective Cohort Study of Impact of Publicly Funded Mechanical Insufflation-exsufflation on Public Health Service Utilization
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Shi, J., primary, Gershon, A.S., additional, Cohen, E., additional, Kiss, A., additional, Rose, L., additional, and Amin, R., additional
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- 2024
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107. Healthcare Utilization and Costs in Children Receiving Home Mechanical Ventilation: A 14-year Cohort Study
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Verma, R., primary, Amin, R., additional, Bai, Y.Q., additional, Guttmann, A., additional, Cohen, E., additional, Gershon, A.S., additional, Katz, S.L., additional, Lim, A., additional, and Rose, L., additional
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- 2024
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108. Lenvatinib ± Pembrolizumab Versus Chemotherapy for Recurrent/Metastatic (R/M) Head and Neck Squamous Cell Carcinoma (HNSCC) That Progressed after Platinum and Immunotherapy: The Phase 2 LEAP-009 Study
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Harrington, K., primary, Kim, H.R., additional, Salas, S., additional, Oliva, M., additional, Metcalf, R., additional, Bernsdorf, M., additional, Kim, J.W., additional, Cohen, E., additional, Siu, L.L., additional, Rischin, D., additional, Licitra, L., additional, Vermorken, J., additional, Le, Q.T., additional, Tahara, M., additional, Machiels, J.P., additional, O'Hara, K., additional, Pathiraja, K., additional, Gumuscu, B., additional, Bidadi, B., additional, and Burtness, B., additional
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- 2024
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109. Abstract No. 547 Comparison of Complete Pathologic Response Rates in Hepatocellular Carcinoma Treated with Thermal Ablation under Conventional Computed Tomography versus Fluoroscopy and Cone-Beam Computed Tomography Guidance
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Restrepo, C., primary, Ricci, J., additional, Baek, G., additional, Frenk, N., additional, Banovac, F., additional, Sabri, S., additional, and Cohen, E., additional
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- 2024
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110. 4D Point Cloud Registration for Tumor Vascular Networks Monitoring from Ultrasensitive Doppler Images
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Cohen, E., Deffieux, T., Demené, C., Cohen, L. D., Tanter, M., Tavares, João Manuel R. S., Series Editor, Jorge, Renato Natal, Series Editor, Ateshian, Gerard A., editor, and Myers, Kristin M., editor
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- 2020
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111. The Chemical Durability of Cement Pastes and Geopolymers Substituted with Dolomite-Based Quarry-Dust
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Cohen, E., Peled, A., Bar-Nes, G., Kovler, Konstantin, editor, Zhutovsky, Semion, editor, Spatari, Sabrina, editor, and Jensen, Ole M., editor
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- 2020
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112. Second-order fluctuation theory and time autocorrelation function for currents
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Belousov, Roman and Cohen, E. G. D.
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Condensed Matter - Statistical Mechanics - Abstract
By using recent developments for the Langevin dynamics of spatially asymmetric systems, we routinely generalize the Onsager-Machlup fluctuation theory of the second order in time. In this form, it becomes applicable to fluctuating variables, including hydrodynamic currents, in equilibrium as well as nonequilibrium steady states. From the solution of the obtained stochastic equations we derive an analytical expression for the time autocorrelation function of a general fluctuating quantity. This theoretical result is then tested in a study of a shear flow by molecular dynamics simulations. The proposed form of the time autocorrelation function yields an excellent fit to our computational data for both equilibrium and nonequilibrium steady states. Unlike the analogous result of the first-order Onsager-Machlup theory, our expression correctly describes the short-time correlations. Its utility is demonstrated in an application of the Green-Kubo formula for the transport coefficient. Curiously, the normalized time autocorrelation function for the shear flow, which only depends on the deterministic part of the fluctuation dynamics, appears independent of the external shear force in the linear nonequilibrium regime.
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- 2016
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113. The Langevin equation for systems with a preferred spatial direction
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Belousov, Roman, Cohen, E. G. D., and Rondoni, Lamberto
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Condensed Matter - Statistical Mechanics - Abstract
In this paper, we generalize the theory of Brownian motion and the Onsager-Machlup theory of fluctuations for spatially symmetric systems to equilibrium and nonequilibrium steady-state systems with a preferred spatial direction, due to an external force. To do this, we extend the Langevin equation to include a bias, which is introduced by the external force and alters the Gaussian structure of the system's fluctuations. By solving this extended equation, we demonstrate that the statistical properties of the fluctuations in these systems can be predicted from physical observables, such as the temperature and the hydrodynamic gradients., Comment: 1 figure
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- 2016
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114. Determination of muon momentum in the MicroBooNE LArTPC using an improved model of multiple Coulomb scattering
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Abratenko, P, Acciarri, R, Adams, C, An, R, Anthony, J, Asaadi, J, Auger, M, Bagby, L, Balasubramanian, S, Baller, B, Barnes, C, Barr, G, Bass, M, Bay, F, Bishai, M, Blake, A, Bolton, T, Bugel, L, Camilleri, L, Caratelli, D, Carls, B, Fernandez, RC, Cavanna, F, Chen, H, Church, E, Cianci, D, Cohen, E, Collin, GH, Conrad, JM, Convery, M, Crespo-Anadón, JI, Tutto, MD, Devitt, D, Dytman, S, Eberly, B, Ereditato, A, Sanchez, LE, Esquivel, J, Fleming, BT, Foreman, W, Furmanski, AP, Garcia-Gamez, D, Garvey, GT, Genty, V, Goeldi, D, Gollapinni, S, Graf, N, Gramellini, E, Greenlee, H, Grosso, R, Guenette, R, Hackenburg, A, Hamilton, P, Hen, O, Hewes, J, Hill, C, Ho, J, Horton-Smith, G, Huang, EC, James, C, De Vries, JJ, Jen, CM, Jiang, L, Johnson, RA, Joshi, J, Jostlein, H, Kaleko, D, Kalousis, LN, Karagiorgi, G, Ketchum, W, Kirby, B, Kirby, M, Kobilarcik, T, Kreslo, I, Laube, A, Li, Y, Lister, A, Littlejohn, BR, Lockwitz, S, Lorca, D, Louis, WC, Luethi, M, Lundberg, B, Luo, X, Marchionni, A, Mariani, C, Marshall, J, Caicedo, DAM, Meddage, V, Miceli, T, Mills, GB, Moon, J, Mooney, M, Moore, CD, Mousseau, J, Murrells, R, Naples, D, Nienaber, P, Nowak, J, and Palamara, O
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Neutrino detectors ,Time projection chambers ,Time projection Chambers ,physics.ins-det ,hep-ex ,Nuclear & Particles Physics ,Physical Sciences ,Engineering - Abstract
We discuss a technique for measuring a charged particle's momentum by means of multiple Coulomb scattering (MCS) in the MicroBooNE liquid argon time projection chamber (LArTPC). This method does not require the full particle ionization track to be contained inside of the detector volume as other track momentum reconstruction methods do (range-based momentum reconstruction and calorimetric momentum reconstruction). We motivate use of this technique, describe a tuning of the underlying phenomenological formula, quantify its performance on fully contained beam-neutrino-induced muon tracks both in simulation and in data, and quantify its performance on exiting muon tracks in simulation. Using simulation, we have shown that the standard Highland formula should be re-tuned specifically for scattering in liquid argon, which significantly improves the bias and resolution of the momentum measurement. With the tuned formula, we find agreement between data and simulation for contained tracks, with a small bias in the momentum reconstruction and with resolutions that vary as a function of track length, improving from about 10% for the shortest (one meter long) tracks to 5% for longer (several meter) tracks. For simulated exiting muons with at least one meter of track contained, we find a similarly small bias, and a resolution which is less than 15% for muons with momentum below 2 GeV/c. Above 2 GeV/c, results are given as a first estimate of the MCS momentum measurement capabilities of MicroBooNE for high momentum exiting tracks.
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- 2017
115. Michel electron reconstruction using cosmic-ray data from the MicroBooNE LArTPC
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Acciarri, R, Adams, C, An, R, Anthony, J, Asaadi, J, Auger, M, Bagby, L, Balasubramanian, S, Baller, B, Barnes, C, Barr, G, Bass, M, Bay, F, Bishai, M, Blake, A, Bolton, T, Bugel, L, Camilleri, L, Caratelli, D, Carls, B, Fernandez, RC, Cavanna, F, Chen, H, Church, E, Cianci, D, Cohen, E, Collin, GH, Conrad, JM, Convery, M, Crespo-Anadón, JI, Tutto, MD, Devitt, D, Dytman, S, Eberly, B, Ereditato, A, Sanchez, LE, Esquivel, J, Fleming, BT, Foreman, W, Furmanski, AP, Garcia-Gamez, D, Garvey, GT, Genty, V, Goeldi, D, Gollapinni, S, Graf, N, Gramellini, E, Greenlee, H, Grosso, R, Guenette, R, Hackenburg, A, Hamilton, P, Hen, O, Hewes, J, Hill, C, Ho, J, Horton-Smith, G, Huang, EC, James, C, De Vries, JJ, Jen, CM, Jiang, L, Johnson, RA, Joshi, J, Jostlein, H, Kaleko, D, Karagiorgi, G, Ketchum, W, Kirby, B, Kirby, M, Kobilarcik, T, Kreslo, I, Laube, A, Li, Y, Lister, A, Littlejohn, BR, Lockwitz, S, Lorca, D, Louis, WC, Luethi, M, Lundberg, B, Luo, X, Marchionni, A, Mariani, C, Marshall, J, Caicedo, DAM, Meddage, V, Miceli, T, Mills, GB, Moon, J, Mooney, M, Moore, CD, Mousseau, J, Murrells, R, Naples, D, Nienaber, P, Nowak, J, Palamara, O, Paolone, V, and Papavassiliou, V
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Neutrino detectors ,Noble liquid detectors ,Performance of High Energy Physics Detectors ,Time projection chambers ,physics.ins-det ,hep-ex ,Nuclear & Particles Physics ,Physical Sciences ,Engineering - Abstract
The MicroBooNE liquid argon time projection chamber (LArTPC) has been taking data at Fermilab since 2015 collecting, in addition to neutrino beam, cosmic-ray muons. Results are presented on the reconstruction of Michel electrons produced by the decay at rest of cosmic-ray muons. Michel electrons are abundantly produced in the TPC, and given their well known energy spectrum can be used to study MicroBooNE's detector response to low-energy electrons (electrons with energies up to ∼ 50 MeV). We describe the fully-automated algorithm developed to reconstruct Michel electrons, with which a sample of ∼ 14,000 Michel electron candidates is obtained. Most of this article is dedicated to studying the impact of radiative photons produced by Michel electrons on the accuracy and resolution of their energy measurement. In this energy range, ionization and bremsstrahlung photon production contribute similarly to electron energy loss in argon, leading to a complex electron topology in the TPC. By profiling the performance of the reconstruction algorithm on simulation we show that the ability to identify and include energy deposited by radiative photons leads to a significant improvement in the energy measurement of low-energy electrons. The fractional energy resolution we measure improves from over 30% to ∼ 20% when we attempt to include radiative photons in the reconstruction. These studies are relevant to a large number of analyses which aim to study neutrinos by measuring electrons produced by νe interactions over a broad energy range.
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- 2017
116. Noise Characterization and Filtering in the MicroBooNE Liquid Argon TPC
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Acciarri, R, Adams, C, An, R, Anthony, J, Asaadi, J, Auger, M, Bagby, L, Balasubramanian, S, Baller, B, Barnes, C, Barr, G, Bass, M, Bay, F, Bishai, M, Blake, A, Bolton, T, Bullard, B, Camilleri, L, Caratelli, D, Carls, B, Fernandez, RC, Cavanna, F, Chen, H, Church, E, Cianci, D, Cohen, E, Collin, GH, Conrad, JM, Convery, M, Crespo-Anadón, JI, Geronimo, GD, Tutto, MD, Devitt, D, Dytman, S, Eberly, B, Ereditato, A, Sanchez, LE, Esquivel, J, Fadeeva, AA, Fleming, BT, Foreman, W, Furmanski, AP, Garcia-Gamez, D, Garvey, GT, Genty, V, Goeldi, D, Gollapinni, S, Graf, N, Gramellini, E, Greenlee, H, Grosso, R, Guenette, R, Hackenburg, A, Hamilton, P, Hen, O, Hewes, J, Hill, C, Ho, J, Horton-Smith, G, Hourlier, A, Huang, EC, James, C, De Vries, JJ, Jen, CM, Jiang, L, Johnson, RA, Joshi, J, Jostlein, H, Kaleko, D, Karagiorgi, G, Ketchum, W, Kirby, B, Kirby, M, Kobilarcik, T, Kreslo, I, Laube, A, Li, S, Li, Y, Lister, A, Littlejohn, BR, Lockwitz, S, Lorca, D, Louis, WC, Luethi, M, Lundberg, B, Luo, X, Marchionni, A, Mariani, C, Marshall, J, Caicedo, DAM, Meddage, V, Miceli, T, Mills, GB, Moon, J, Mooney, M, Moore, CD, Mousseau, J, Murrells, R, Naples, D, and Nienaber, P
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Front-end electronics for detector readout ,Neutrino detectors ,Noble liquid detectors ,Time projection Chambers ,physics.ins-det ,hep-ex ,Nuclear & Particles Physics ,Physical Sciences ,Engineering - Abstract
The low-noise operation of readout electronics in a liquid argon time projection chamber (LArTPC) is critical to properly extract the distribution of ionization charge deposited on the wire planes of the TPC, especially for the induction planes. This paper describes the characteristics and mitigation of the observed noise in the MicroBooNE detector. The MicroBooNE's single-phase LArTPC comprises two induction planes and one collection sense wire plane with a total of 8256 wires. Current induced on each TPC wire is amplified and shaped by custom low-power, low-noise ASICs immersed in the liquid argon. The digitization of the signal waveform occurs outside the cryostat. Using data from the first year of MicroBooNE operations, several excess noise sources in the TPC were identified and mitigated. The residual equivalent noise charge (ENC) after noise filtering varies with wire length and is found to be below 400 electrons for the longest wires (4.7 m). The response is consistent with the cold electronics design expectations and is found to be stable with time and uniform over the functioning channels. This noise level is significantly lower than previous experiments utilizing warm front-end electronics.
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- 2017
117. Pandemic of sensitivity to acrylate containing nail cosmetic among young Israeli women? Result of patch testing 2‐hydroxyethyl methacrylate in the European baseline series.
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Hilewitz, D., Trattner, A., Reiter, O., Uvaidov, V., Noyman, Y., Solomon Cohen, E., Hackett, A., Mimouni, D., and Snast, I.
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OLDER women ,AGE groups ,YOUNG women ,SANITARY napkins ,CONTACT dermatitis - Abstract
Background: 2‐Hydroxyethyl methacrylate (HEMA) was added into the European baseline series (EBS) in 2019. There is limited data regarding the frequency, relevance, and sources of exposure to HEMA. Objectives: To investigate the frequency and clinical relevance of positive reactions to HEMA in the EBS in Israel, and explore sources of exposure. Methods: Retrospective cohort study that included all patients who underwent patch testing with the EBS in a tertiary center in Israel between 2020 and 2023. Positive reactions to HEMA were stratified by sex, six age groups, and year of study. Sources of exposure to HEMA as well as occupational data were recorded. Results: A total of 1671 consecutive patients underwent HEMA patch testing, with 135 (8.1%) showing positive reactions to HEMA (130 females, 5 males). The prevalence in women (11.0%) was significantly higher compared to men (1.0%) (p < 0.001). Stratification by age and sex revealed the highest frequency of HEMA sensitivity of 16.7% among women younger than 30 years of age, with odds ratio of 2.3 (95%CI: 1.6–3.3, p < 0.001) compared to older women. There was an increase in frequency among women between the years 2022 and 2023 when compared to 2020–2021 (OR 1.7, 95%CI: 1.5–2.1, p < 0.01) attributable to COVID‐19 pandemic and social restrictions. Among men the frequency fluctuations over the study period and age categories were nonsignificant. 111 (84%) were judged to be of clinical relevance and nail cosmetics was responsible for 95% of them. Of 111 patients with relevant reaction (110 females, 1 males), 20 (18%) had occupational contact dermatitis (18 nails stylists, 2 dentists). Other culprit products included sanitary pads (n = 4), medical adhesives (n = 3), and paints (n = 2). Conclusion: We report the highest frequency of HEMA sensitivity to date of 8.1%, that was most common among young women and in vast majority of cases was attributable to nail cosmetics. Our findings reflect the popularity of nail cosmetics in Israel as well as the global trend of increasing sensitivity to (meth)acrylates. [ABSTRACT FROM AUTHOR]
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- 2024
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118. Estimation of Body Mass Index from photographs using deep Convolutional Neural Networks
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Pantanowitz, A., Cohen, E., Gradidge, P., Crowther, N.J., Aharonson, V., Rosman, B., and Rubin, D.M.
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- 2021
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119. Inertia Sets For Families of Graphs
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Cohen, E. B., Nguyen, N. H., Winde, J. G., and Yielding, A. A
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Mathematics - Combinatorics - Abstract
This paper consists of a few results, discovered and proved during the 2012-2013 research group at Eastern Oregon University. Inertia tables are a visual representation of the possible inertias of a given graph. The inertia of a graph counts the number of real positive and negative eigenvalues of its corresponding adjacency matrix. The problem of studying inertia tables is directly related to the inverse eigenvalue problem and can be used as a tool for the minimum rank problem. This paper describes the inverse eigenvalue problem, and tools used. We describe a number of new general formulas for various simple undirected graphs and improved upon an established notation for inertia tables., Comment: Published in Eastern Oregon Science Journal
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- 2015
120. Subdiffusion, Anomalous Diffusion and Propagation of a Particle Moving in Random and Periodic Media
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Mishra, Shradha, Bhattacharya, Sanchari, Webb, Benjamin, and Cohen, E. G. D.
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Condensed Matter - Statistical Mechanics - Abstract
We investigate the motion of a single particle moving on a two-dimensional square lattice whose sites are occupied by right and left rotators. These left and right rotators deterministically rotate the particle's velocity to the right or left, respectively and \emph{flip} orientation from right to left or from left to right after scattering the particle. We study three types of configurations of left and right rotators, which we think of as types of media, through with the particle moves. These are completely random (CR), random periodic (RP), and completely periodic (CP) configurations. For CR configurations the particle's dynamics depends on the ratio $r$ of right to left scatterers in the following way. For small $r\simeq0$, when the configuration is nearly homogeneous, the particle subdiffuses with an exponent of 2/3, similar to the diffusion of a macromolecule in a crowded environment. Also, the particle's trajectory has a fractal dimension of $d_f\simeq4/3$, comparable to that of a self-avoiding walk. As the ratio increases to $r\simeq 1$, the particle's dynamics transitions from subdiffusion to anomalous diffusion with a fractal dimension of $d_f\simeq 7/4$, similar to that of a percolating cluster in 2-d. In RP configurations, which are more structured than CR configurations but also randomly generated, we find that the particle has the same statistic as in the CR case. In contrast, CP configurations, which are highly structured, typically will cause the particle to go through a transient stage of subdiffusion, which then abruptly changes to propagation. Interestingly, the subdiffusive stage has an exponent of approximately 2/3 and a fractal dimension of $d_f\simeq4/3$, similar to the case of CR and RP configurations for small $r$., Comment: 16 pages, 9 figures
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- 2015
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121. Asymmetry of steady state current fluctuations in nonequilibrium systems
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Belousov, Roman and Cohen, E. G. D.
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Condensed Matter - Statistical Mechanics - Abstract
For systems in nonequilibrium steady states, a novel modulated Gaussian probability distribution is derived to incorporate a new phenomenon of biased current fluctuations, discovered by recent laboratory experiments and confirmed by molecular dynamics simulations. Our results consistently extend Onsager-Machlup fluctuation theory for systems in thermal equilibrium. Connections with the principles of Statistical Mechanics due to Boltzmann and Gibbs are discussed. At last, the modulated Gaussian distribution is of potential interest for other statistical disciplines, which make use of the Large Deviation theory., Comment: 10 pages, 2 figures
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- 2015
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122. Measuring incompatible observables of a single photon
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Piacentini, F., Levi, M. P., Avella, A., Cohen, E., Lussana, R., Villa, F., Tosi, A., Zappa, F., Gramegna, M., Brida, G., Degiovanni, I. P., and Genovese, M.
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Quantum Physics - Abstract
One of the most intriguing aspects of Quantum Mechanics is the impossibility of measuring at the same time observables corresponding to non-commuting operators. This impossibility can be partially relaxed when considering joint or sequential weak values evaluation. Indeed, weak measurements have been a real breakthrough in the quantum measurement framework that is of the utmost interest from both a fundamental and an applicative point of view. Here we show how we realized, for the first time, a sequential weak value evaluation of two incompatible observables on a single photon., Comment: 5 pages, 3 figures
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- 2015
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123. Self-Limiting Trajectories of a Particle Moving Deterministically in a Random Medium
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Webb, Benjamin and Cohen, E. G. D.
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Mathematical Physics - Abstract
We study the motion of a particle moving on a two-dimensional honeycomb lattice, whose sites are randomly occupied by either right or left rotators, which rotate the particle's velocity to its right or left, according to deterministic rules. In the model we consider, the scatterers are each initially oriented to the right with probability $p\in[0,1]$. This is done independently, so that the initial configuration of scatterers, which forms the medium through which the particle moves, are both independent and identically distributed. For $p\in(0,1)$, we show that as the particle moves through the lattice, it creates a number of reflecting structures. These structures ultimately \emph{limit} the particle's motion, causing it to have a periodic trajectory. As $p$ approaches either 0 or 1, and the medium becomes increasingly homogenous, the particle's dynamics undergoes a discontinuous transition from this self-limiting, periodic motion to a self-avoiding motion, where the particle's trajectory, away from its initial position, is a self-avoiding walk. Additionally, we show that the periodic dynamics observed for $p\in(0,1)$ can persist, even if the initial configuration of scatterers are not identically distributed. Furthermore, we show that if these orientations are not chosen independently, this can drastically change the particle's motion causing it to have a behavior that is nonperiodic., Comment: 35 pages, 14 figures
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- 2015
124. Cramer-Rao Lower Bound for Point Based Image Registration with Heteroscedastic Error Model for Application in Single Molecule Microscopy
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Cohen, E. A. K., Kim, D., and Ober, R. J.
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Statistics - Methodology - Abstract
The Cramer-Rao lower bound for the estimation of the affine transformation parameters in a multivariate heteroscedastic errors-in-variables model is derived. The model is suitable for feature-based image registration in which both sets of control points are localized with errors whose covariance matrices vary from point to point. With focus given to the registration of fluorescence microscopy images, the Cramer-Rao lower bound for the estimation of a feature's position (e.g. of a single molecule) in a registered image is also derived. In the particular case where all covariance matrices for the localization errors are scalar multiples of a common positive definite matrix (e.g. the identity matrix), as can be assumed in fluorescence microscopy, then simplified expressions for the Cramer-Rao lower bound are given. Under certain simplifying assumptions these expressions are shown to match asymptotic distributions for a previously presented set of estimators. Theoretical results are verified with simulations and experimental data.
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- 2015
125. On the Transition of a Non-Equilibrium System to an Equilibrium System
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Cohen, E. G. D.
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Condensed Matter - Statistical Mechanics - Abstract
It is shown that the most important feature of Non-Equilibrium Thermodynamics is not the entropy production, but the organization of the currents in order to flow. This is also needed to obtain the maximum entropy in the equilibrium state, as is required by Equilibrium Thermodynamics., Comment: 6 pages, 1 figure
- Published
- 2015
126. Differences in maternal–newborn ABO blood groups and risk of serious infant infection.
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Butler, E A, Grandi, S M, Matai, L, Wang, X, Cohen, E, and Ray, J G
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ABO blood group system ,BLOOD groups ,PROPORTIONAL hazards models ,NEONATAL infections ,MATERNAL age - Abstract
Background During pregnancy, various maternal IgG antibodies are transferred to the developing fetus, some of which may protect the newborn against infection. If a mother and her fetus have different A, B or O (ABO) blood groups, then transferred maternal antibodies may plausibly protect the infant against infection. Aim To determine if maternal–newborn ABO blood group incongruence vs. congruence is associated with a lower risk of serious infection in the infant. Design Retrospective population-based cohort. Methods We used linked patient-level datasets for all singleton hospital livebirths from 2008 to 2022 in Ontario, Canada, with known maternal and newborn ABO blood groups. We used a dichotomous exposure state, either ABO blood group congruent (N = 114 507) or incongruent (N = 43 074). The main outcome of interest was the risk of serious infant infection within 27 days, and from 28 to 365 days, after birth. Cox proportional hazard models generated hazard ratios and 95% confidence intervals, and were adjusted for maternal age, world region of origin, residential income quintile and gestational age at birth. Results Relative to maternal–newborn congruency, incongruent ABO blood group was associated with an adjusted hazard ratio of 0.88 (95% CI: 0.80–0.97) for serious neonatal infection within 27 days of birth, and 0.93 (95% CI: 0.90–0.96) for serious infection between 28 and 365 days after birth. Conclusions Maternal–newborn ABO incongruence may be associated with a lower relative risk of a serious infant infection within 27 days, and from 28 to 365 days, after birth. [ABSTRACT FROM AUTHOR]
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- 2024
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127. Markers of Chronic Inflammation in Overweight and Obese Individuals and the Role of Gender: A Cross-Sectional Study of a Large Cohort
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Cohen E, Margalit I, Shochat T, Goldberg E, and Krause I
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gender ,inflammatory markers ,body mass index. ,Pathology ,RB1-214 ,Therapeutics. Pharmacology ,RM1-950 - Abstract
Eytan Cohen,1,2 Ili Margalit,1,2 Tzippy Shochat,3 Elad Goldberg,1,2 Ilan Krause1,2 1Department of Medicine F - Recanati, Rabin Medical Center – Beilinson Hospital, Petach Tikva, Israel; 2Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv, Israel; 3Statistical Counselling Unit, Rabin Medical Center – Beilinson Hospital, Petach Tikva, IsraelCorrespondence: Eytan CohenDepartment of Medicine F - Recanati, Rabin Medical Center – Beilinson Hospital, Petach Tikva, 4941492, IsraelTel +972-3-9377361Fax +972-3-9244663Email dreytancohen@gmail.comObjective: During the last decade, obesity has become an epidemic. As obesity is now considered a state of low-grade inflammation, the purpose of this study was to assess the prevalence of four common elements of inflammation, in individuals with increased BMI. These findings were compared to those of subjects with normal BMI. The effect of gender was also noted.Methods: Data were collected from medical records of individuals examined at a screening center in Israel between the years 2000– 2014. Cross-sectional analysis was carried out on 7526 men and 3219 women. White blood cell count (WBC); platelet (PLT) count; erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) were assessed in four BMI categories: normal, overweight, obese and morbidly obese.Results: Mean (SD) age of the study sample was 47.5 (9.7) and 46.7 (9.8) years for men and women, respectively. The prevalence of each inflammatory marker increased significantly when comparing abnormal to normal BMI (p< 0.0001). The odds ratio (OR) of the prevalence of increased inflammatory markers was compared between subjects with overweight, obese and morbid obesity and subjects with normal BMI. This study showed that the higher the BMI, the higher the OR. For those in the morbid obesity group, the OR for the different inflammatory markers adjusting for age, diabetes mellitus hypertension and kidney function were as follows: WBC levels, 5.1 (2.9– 8.7) and 4.7 (2.4– 9.1) for men and women, respectively; PLT levels, 1.7 (0.3– 8.5) and 2.0 (0.6– 7.2) for men and women, respectively; ESR levels, 4.2 (3.2– 5.4) and 4.6 (3.2– 6.6) for men and women, respectively, and CRP levels, 13.4 (10.0– 18.2) and 19.2 (12.9– 28.6) for men and women, respectively.Conclusion: Inflammatory markers are significantly higher in subjects with abnormal compared to normal BMI. This difference was found to be greater in women than in men.Keywords: gender, inflammatory markers, body mass index
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- 2021
128. A randomized phase 1 study of the anti‐interleukin‐33 antibody tozorakimab in healthy adults and patients with chronic obstructive pulmonary disease
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Reid, Fred, primary, Singh, Dave, additional, Albayaty, Muna, additional, Moate, Rachel, additional, Jimenez, Eulalia, additional, Sadiq, Muhammad Waqas, additional, Howe, David, additional, Gavala, Monica, additional, Killick, Helen, additional, Williams, Adam, additional, Krishnan, Surekha, additional, Godwood, Alex, additional, Shukla, Animesh, additional, Hewitt, Lisa, additional, Lei, Alejhandra, additional, Kell, Chris, additional, Pandya, Hitesh, additional, Newcombe, Paul, additional, White, Nicholas, additional, Scott, Ian C., additional, and Cohen, E. Suzanne, additional
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- 2023
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129. Sarcoïdoses cutanées hypodermiques : étude française multicentrique de 80 patients
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Chauffier, J., primary, Chasset, F., additional, Battistella, M., additional, Jachiet, M., additional, Vignon Pennamen, M.D., additional, Bégon, E., additional, Cohen, E., additional, Bessis, D., additional, De Masson, A., additional, Abisror, N., additional, Jachiet, V., additional, Gottlieb, J., additional, Brenaut, E., additional, Bergeret, B., additional, Debarbieux, S., additional, Gazengel, P., additional, Tazi, A., additional, Nunes, H., additional, Bouaziz, J.D., additional, and Mahévas, T., additional
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- 2023
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130. Organization and dissipation of currents in non-equilibrium thermodynamics
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Cohen, E. G. D.
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Condensed Matter - Statistical Mechanics - Abstract
A dynamical theory for the organization and dissipation of a current in a non-equilibrium fluid near equilibrium is presented. This is based on the Lyapunov exponents of the phase space of the system., Comment: 4pgs
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- 2014
131. Self-Avoiding Modes of Motion in a Deterministic Lorentz Lattice Gas
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Webb, Benjamin and Cohen, E. G. D.
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Mathematical Physics ,76M28, 37K60 - Abstract
We study the motion of a particle on the two-dimensional honeycomb lattice, whose sites are occupied by either flipping rotators or flipping mirrors, which scatter the particle according to a deterministic rule. For both types of scatterers we find a new type of motion that has not been observed in a Lorentz Lattice gas, where the particle's trajectory is a self-avoiding walk between returns to its initial position. We show that this behavior is a consequence of the deterministic scattering rule and the particular class of initial scatterer configurations we consider. Since self-avoiding walks are one of the main tools used to model the growth of crystals and polymers, the particle's motion in this class of systems is potentially important for the study of these processes., Comment: 32 pages, 18 figures
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- 2014
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132. Clausius' Entropy Revisited
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Cohen, E. G. D. and Merlino, R. L.
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Condensed Matter - Statistical Mechanics - Abstract
Conventional Non-equilibrium Thermodynamics is mainly concerned with systems in local equilibrium and their entropy production, due to the irreversible processes which take place in these systems. In this paper fluids will be considered in a state of local equilibrium. We argue that the main feature of such systems is not the entropy production, but the organization of the flowing currents in such systems. These currents do not only have entropy production, but must also have an organization needed to flow in a certain direction. It is the latter, which is the source of the equilibrium entropy, when the fluid goes from a local equilibrium state and to an equilibrium state. This implies a transmutation of the local equilibrium current's organization into the equilibrium entropy. Alternatively, when a fluid goes from an equilibrium state to a local equilibrium state, its entropy transmutes into the organization of the currents of that state.
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- 2014
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133. Methods for Measuring the Time of Transfer from Pediatric to Adult Care for Chronic Conditions Using Administrative Data: A Scoping Review
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Shulman R, Cohen E, Benchimol EI, and Nakhla M
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transfer to adult care ,administrative data ,chronic disease ,Infectious and parasitic diseases ,RC109-216 - Abstract
Rayzel Shulman,1,2 Eyal Cohen,3 Eric I Benchimol,4 Meranda Nakhla5,6 1Department of Pediatrics, Division of Endocrinology, The Hospital for Sick Children, Toronto, ON, Canada; 2Sickkids Research Institute, Child Health Evaluative Sciences, Toronto, ON, Canada; 3Department of Pediatrics, The Hospital for Sick Children, Toronto, ON, Canada; 4Department of Pediatrics, Division of Gastroenterology, Children’s Hospital of Eastern Ontario, Ottawa, ON, Canada; 5Department of Pediatrics, Division of Endocrinology, Montreal Children’s Hospital, Montreal, QC, Canada; 6Center of Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, Montreal, QC, CanadaCorrespondence: Meranda NakhlaCenter of Outcomes Research and Evaluation, Research Institute of the McGill University Health Centre, 5252 de Maisonneuve Blvd, W, 3rd Floor, Montreal, QC H4A 3S5, CanadaTel +1-514-412-4400 Ext 23698Email meranda.nakhla@mcgill.caPurpose: To describe methods used to identify the timing of transfer from pediatric to adult care within health administrative data and to identify the advantages and limitations of each method to guide future research.Study Design and Settings: We conducted a scoping review to identify studies, summarized challenges of identifying the timing of transfer, and proposed methodological approaches for each.Results: Studies use the following approaches to capture individuals who transfer from pediatric to adult care by 1) defining the timing of transfer by the last pediatric and first adult care visit last and 2) defining transfer to adult care based on a specific age.Conclusion: There are important limitations of administrative data that must be recognized in designing studies examining the transfer to adult care.Keywords: transfer to adult care, administrative data, chronic disease
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- 2020
134. ILC2-driven innate immune checkpoint mechanism antagonizes NK cell antimetastatic function in the lung
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Schuijs, Martijn J., Png, Shaun, Richard, Arianne C., Tsyben, Anastasia, Hamm, Gregory, Stockis, Julie, Garcia, Celine, Pinaud, Silvain, Nicholls, Ashley, Ros, Xavier Romero, Su, Jing, Eldridge, Matthew D., Riedel, Angela, Serrao, Eva M., Rodewald, Hans-Reimer, Mack, Matthias, Shields, Jacqueline D., Cohen, E. Suzanne, McKenzie, Andrew N. J., Goodwin, Richard J. A., Brindle, Kevin M., Marioni, John C., and Halim, Timotheus Y. F.
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- 2020
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135. Comment on the Theory of the Stretching Experiments of RNA in Water
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Cohen, E. G. D.
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Condensed Matter - Soft Condensed Matter - Abstract
Is is argued that the stretching experiments done on RNA in water can be described as a reversible process by Classical Thermodynamics., Comment: 3 pages
- Published
- 2013
136. Note on the nature of the transition between a system in an equilibrium state and a system in a non-equilibrium state (and vice-versa)
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Cohen, E. G. D. and Merlino, R. L.
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Condensed Matter - Statistical Mechanics ,Physics - Plasma Physics - Abstract
The transition from a non-equilibrium state to an equilibrium state is characterized not only by the disappearance of the entropy production, but mainly by the disappearance of the organized currents, due to the gradients present in a non-equilibrium system. Their disappearance is necessary to obtain maximum entropy in the equilibrium state.
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- 2013
137. Einstein and Boltzmann: Determinism and Probability or The Virial Expansion Revisited
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Cohen, E. G. D.
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Condensed Matter - Statistical Mechanics - Abstract
Boltzmann's Principle S = k ln W was repeatedly criticized by Einstein since it lacked a proper dynamical foundation in view of the thermal motion of the particles, out of which a physical system consists. This suggests, in particular, that the statistical mechanics of a system in thermal equilibrium should be based on dynamics. As an example, a dynamical derivation of the density expansions of the two-particle distribution function, as well as of the thermodynamic properties of a moderately dense gas in thermal equilibrium, is outlined here. This is a different derivation than the usual one based on Gibbs' probabilistic canonical ensemble, where dynamics is eliminated at the beginning and equilibrium statistical mechanics is reduced to statics. It is argued that the present derivation in this paper could, in principle, also be applied to other equilibrium properties and perhaps also to other fields.
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- 2013
138. 3D Vessel Extraction in the Rat Brain from Ultrasensitive Doppler Images
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Cohen, E., Deffieux, T., Demené, C., Cohen, L. D., Tanter, M., Gefen, Amit, editor, and Weihs, Daphne, editor
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- 2018
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139. Integration of hindbrain and carotid body mechanisms that control the autonomic response to cardiorespiratory and glucoprivic insults
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Kakall, Zohra M., Cohen, E. Myfanwy, Farnham, Melissa M.J., Kim, Seung Jae, Nedoboy, Polina E., and Pilowsky, Paul M.
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- 2019
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140. Urban young women's preferences for intervention strategies to promote physical and mental health preconception: A Healthy Life Trajectories Initiative (HeLTI)
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Draper, C.E., Bosire, E., Prioreschi, A., Ware, L.J., Cohen, E., Lye, S.J., and Norris, S.A.
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- 2019
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141. Comparative Effectiveness of a Second Tumor Necrosis Factor Inhibitor Versus a Non–Tumor Necrosis Factor Biologic in the Treatment of Patients With Polyarticular‐Course Juvenile Idiopathic Arthritis
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Mannion, Melissa L., Amin, Shahla, Balevic, Stephen, Chang, Min‐Lee, Correll, Colleen K., Kearsley‐Fleet, Lianne, Hyrich, Kimme L., Beukelman, Timothy, Aamir, R., Abulaban, K., Adams, A., Aguiar Lapsia, C., Akinsete, A., Akoghlanian, S., Al Manaa, M., AlBijadi, A., Allenspach, E., Almutairi, A., Alperin, R., Amarilyo, G., Ambler, W., Amoruso, M., Angeles‐Han, S., Ardoin, S., Armendariz, S., Asfaw, L., Aviran Dagan, N., Bacha, C., Balboni, I., Balevic, S., Ballinger, S., Baluta, S., Barillas‐Arias, L., Basiaga, M., Baszis, K., Baxter, S., Becker, M., Begezda, A., Behrens, E., Beil, E., Benseler, S., Bermudez‐Santiago, L., Bernal, W., Bigley, T., Bingham, C., Binstadt, B., Black, C., Blackmon, B., Blakley, M., Bohnsack, J., Boneparth, A., Bradfield, H., Bridges, J., Brooks, E., Brothers, M., Brunner, H., Buckley, L., Buckley, M., Buckley, M., Bukulmez, H., Bullock, D., Canna, S., Cannon, L., Canny, S., Cartwright, V., Cassidy, E., Castro, D., Chalom, E., Chang, J., Chang, M., Chang, J., Chang‐Hoftman, A., Chen, A., Chiraseveenuprapund, P., Ciaglia, K., Co, D., Cohen, E., Collinge, J., Conlon, H., Connor, R., Cook, K., Cooper, A., Cooper, J., Corbin, K., Correll, C., Cron, R., Curry, M., Dalrymple, A., Datyner, E., Davis, T., De Ranieri, D., Dean, J., DeCoste, C., Dedeoglu, F., DeGuzman, M., Delnay, N., DeSantis, E., Devine, R., Dhalla, M., Dhanrajani, A., Dissanayake, D., Dizon, B., Drapeau, N., Drew, J., Driest, K., Du, Q., Duncan, E., Dunnock, K., Durkee, D., Dvergsten, J., Eberhard, A., Ede, K., Edelheit, B., Edens, C., El Tal, T., Elder, M., Elzaki, Y., Fadrhonc, S., Failing, C., Fair, D., Favier, L., Feldman, B., Fennell, J., Ferguson, P., Ferguson, I., Figueroa, C., Flanagan, E., Fogel, L., Fox, E., Fox, M., Franklin, L., Fuhlbrigge, R., Fuller, J., Furey, M., Futch‐West, T., Gagne, S., Gennaro, V., Gerstbacher, D., Gilbert, M., Gironella, A., Glaser, D., Goh, I., Goldsmith, D., Gorry, S., Goswami, N., Gottlieb, B., Graham, T., Grevich, S., Griffin, T., Grim, A., Grom, A., Guevara, M., Hahn, T., Halyabar, O., Hamda Natur, M., Hammelev, E., Hammond, T., Harel, L., Harris, J., Harry, O., Hausmann, J., Hay, A., Hays, K., Hayward, K., Henderson, L., Henrickson, M., Hersh, A., Hickey, K., Hiraki, L., Hiskey, M., Hobday, P., Hoffart, C., Holland, M., Hollander, M., Hong, S., Horton, D., Horwitz, M., Hsu, J., Huber, A., Huberts, A., Huggins, J., Huie, L., Hui‐Yuen, J., Ibarra, M., Imlay, A., Imundo, L., Inman, C., Jackson, A., James, K., Janow, G., Jared, S., Jiang, Y., Johnson, L., Johnson, N., Jones, J., Kafisheh, D., Kahn, P., Kaidar, K., Kasinathan, S., Kaur, R., Kessler, E., Kienzle, B., Kim, S., Kimura, Y., Kingsbury, D., Kitcharoensakkul, M., Klausmeier, T., Klein, K., Klein‐Gitelman, M., Knight, A., Kovalick, L., Kramer, S., Kremer, C., Kudas, O., LaFlam, T., Lang, B., Lapidus, S., Lapin, B., Lasky, A., Lawler, C., Lawson, E., Laxer, R., Lee, P., Lee, P., Lee, T., Lee, A., Leisinger, E., Lentini, L., Lerman, M., Levinsky, Y., Levy, D., Li, S., Lieberman, S., Lim, L., Limenis, E., Lin, C., Ling, N., Lionetti, G., Livny, R., Lloyd, M., Lo, M., Long, A., Lopez‐Peña, M., Lovell, D., Luca, N., Lvovich, S., Lytch, A., Ma, M., Machado, A., MacMahon, J., Madison, J., Mannion, M., Manos, C., Mansfield, L., Marston, B., Mason, T., Matchett, D., McAllister, L., McBrearty, K., McColl, J., McCurdy, D., McDaniels, K., McDonald, J., Meidan, E., Mellins, E., Mian, Z., Miettunen, P., Miller, M., Milojevic, D., Mitacek, R., Modica, R., Mohan, S., Moore, T., Moore, K., Moorthy, L., Moreno, J., Morgan, E., Moyer, A., Murante, B., Murphy, A., Muscal, E., Mwizerwa, O., Najafi, A., Nanda, K., Nasah, N., Nassi, L., Nativ, S., Natter, M., Nearanz, K., Neely, J., Newhall, L., Nguyen, A., Nigrovic, P., Nocton, J., Nolan, B., Nowicki, K., Oakes, R., Oberle, E., Ogbonnaya‐Whittesley, S., Ogbu, E., Oliver, M., Olveda, R., Onel, K., Orandi, A., Padam, J., Paller, A., Pan, N., Pandya, J., Panupattanapong, S., Toledano, A. Pappo, Parsons, A., Patel, J., Patel, P., Patrick, A., Patrizi, S., Paul, S., Perfetto, J., Perron, M., Peskin, M., Ponder, L., Pooni, R., Prahalad, S., Puplava, B., Quinlan‐Waters, M., Rabinovich, C., Rafko, J., Rahimi, H., Rampone, K., Ramsey, S., Randell, R., Ray, L., Reed, A., Reed, A., Reid, H., Reiff, D., Richins, S., Riebschleger, M., Rife, E., Riordan, M., Riskalla, M., Robinson, A., Robinson, L., Rodgers, L., Rodriquez, M., Rogers, D., Ronis, T., Rosado, A., Rosenkranz, M., Rosenwasser, N., Rothermel, H., Rothman, D., Rothschild, E., Roth‐Wojcicki, E., Rouster‐Stevens, K., Rubinstein, T., Rupp, J., Ruth, N., Sabbagh, S., Sadun, R., Santiago, L., Saper, V., Sarkissian, A., Scalzi, L., Schahn, J., Schikler, K., Schlefman, A., Schmeling, H., Schmitt, E., Schneider, R., Schulert, G., Schultz, K., Schutt, C., Seper, C., Sheets, R., Shehab, A., Shenoi, S., Sherman, M., Shirley, J., Shishov, M., Siegel, D., Singer, N., Sivaraman, V., Sloan, E., Smith, C., Smith, J., Smitherman, E., Soep, J., Son, Mary B., Sosna, D., Spencer, C., Spiegel, L., Spitznagle, J., Srinivasalu, H., Stapp, H., Steigerwald, K., Stephens, A., Sterba Rakovchik, Y., Stern, S., Stevens, B., Stevenson, R., Stewart, K., Stewart, W., Stingl, C., Stoll, M., Stringer, E., Sule, S., Sullivan, J., Sundel, R., Sutter, M., Swaffar, C., Swayne, N., Syed, R., Symington, T., Syverson, G., Szymanski, A., Taber, S., Tal, R., Tambralli, A., Taneja, A., Tanner, T., Tarvin, S., Tate, L., Taxter, A., Taylor, J., Tesher, M., Thakurdeen, T., Theisen, A., Thomas, B., Thomas, L., Thomas, N., Ting, T., Todd, C., Toib, D., Toib, D., Torok, K., Tory, H., Toth, M., Tse, S., Tsin, C., Twachtman‐Bassett, J., Twilt, M., Valcarcel, T., Valdovinos, R., Vallee, A., Van Mater, H., Vandenbergen, S., Vannoy, L., Varghese, C., Vasquez, N., Vega‐Fernandez, P., Velez, J., Verbsky, J., Verstegen, R., Scheven, E., Vora, S., Wagner‐Weiner, L., Wahezi, D., Waite, H., Walker, B., Walters, H., Waterfield, M., Waters, A., Weiser, P., Weiss, P., Weiss, J., Wershba, E., Westheuser, V., White, A., Widrick, K., Williams, C., Wong, S., Woolnough, L., Wright, T., Wu, E., Yalcindag, A., Yasin, S., Yeung, R., Yomogida, K., Zeft, A., Zhang, Y., Zhao, Y., and Zhu, A.
- Abstract
The objective of this study was to compare the effectiveness of a second tumor necrosis factor inhibitor (TNFi) versus a non‐TNFi biologic following discontinuation of a TNFi for patients with polyarticular‐course juvenile idiopathic arthritis (pJIA). Using the Childhood Arthritis and Rheumatology Research Alliance Registry, patients with pJIA who started receiving a second biologic following a first TNFi were identified. Patients were required to have no active uveitis on the index date and a visit six months after the index date. Outcome measures included Clinical Juvenile Arthritis Disease Activity Score with a maximum of 10 active joints (cJADAS10), cJADAS10 inactive disease (ID; ≤2.5) and cJADAS10 minimal disease activity (MiDA; ≤5). Multiple imputation was used to account for missing data. Adjusted odds ratios (aORs) were calculated using propensity score quintiles to compare outcomes at six months following second biologic initiation. There were 216 patients included, 84% initially received etanercept, and most patients stopped receiving it because of its ineffectiveness (74%). A total of 183 (85%) started receiving a second TNFi, and 33 (15%) started receiving a non‐TNFi. Adalimumab was the most common second biologic received (71% overall, 84% of second TNFi), and tocilizumab was the most common non‐TNFi second biologic received (9% overall, 58% of non‐TNFi). There was no difference between receiving TNFi versus non‐TNFi in cJADAS10 ID (29% vs 25%; aOR 1.23, 95% confidence interval [CI] 0.47–3.20) or at least MiDA (43% vs 39%; aOR 1.11, 95% CI 0.47–2.62) at six months. Most patients with pJIA started receiving TNFi rather than non‐TNFi as their second biologic, and there were no differences in disease activity at six months.
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- 2024
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142. Green-Kubo relation for viscosity tested using experimental data for a 2D dusty plasma
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Feng, Yan, Goree, J., Liu, Bin, and Cohen, E. G. D.
- Subjects
Physics - Plasma Physics - Abstract
The theoretical Green-Kubo relation for viscosity is tested using experimentally obtained data. In a dusty plasma experiment, micron-size dust particles are introduced into a partially-ionized argon plasma, where they become negatively charged. They are electrically levitated to form a single-layer Wigner crystal, which is subsequently melted using laser heating. In the liquid phase, these dust particles experience interparticle electric repulsion, laser heating, and friction from the ambient neutral argon gas, and they can be considered to be in a nonequilibrium steady state. Direct measurements of the positions and velocities of individual dust particles are then used to obtain a time series for an off-diagonal element of the stress tensor and its time autocorrelation function. This calculation also requires the interparticle potential, which was not measured experimentally, but was obtained using a Debye-H\"{u}ckel-type model with experimentally determined parameters. Integrating the autocorrelation function over time yields the viscosity for shearing motion amongst dust particles. The viscosity so obtained is found to agree with results from a previous experiment using a hydrodynamical Navier-Stokes equation. This comparison serves as a test of the Green-Kubo relation for viscosity. Our result is also compared to the predictions of several simulations., Comment: 11 pages, 5 figures, 1 table, in press Physical Review E 2011
- Published
- 2011
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143. Jet-like tunneling from a trapped vortex
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Cohen, E., Muenzel, S., Fleischer, J., Fleurov, V., and Soffer, A.
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Condensed Matter - Quantum Gases - Abstract
We analyze the tunneling of vortex states from elliptically shaped traps. Using the hydrodynamic representation of the Gross-Pitaevskii (Nonlinear Schr\"odinger) equation, we derive analytically and demonstrate numerically a novel type of quantum fluid flow: a jet-like singularity formed by the interaction between the vortex and the nonhomogenous field. For strongly elongated traps, the ellipticity overwhelms the circular rotation, resulting in the ejection of field in narrow, well-defined directions. These jets can also be understood as a formation of caustics since they correspond to a convergence of trajectories starting from the top of the potential barrier and meeting at a certain point on the exit line. They will appear in any coherent wave system with angular momentum and non-circular symmetry, such as superfluids, Bose-Einstein condensates, and light., Comment: 4 pages, 4 figures
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- 2011
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144. Stick-slip motion of solids with dry friction subject to random vibrations and an external field
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Baule, A., Touchette, H., and Cohen, E. G. D.
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Condensed Matter - Statistical Mechanics - Abstract
We investigate a model for the dynamics of a solid object, which moves over a randomly vibrating solid surface and is subject to a constant external force. The dry friction between the two solids is modeled phenomenologically as being proportional to the sign of the object's velocity relative to the surface, and therefore shows a discontinuity at zero velocity. Using a path integral approach, we derive analytical expressions for the transition probability of the object's velocity and the stationary distribution of the work done on the object due to the external force. From the latter distribution, we also derive a fluctuation relation for the mechanical work fluctuations, which incorporates the effect of the dry friction., Comment: v1: 23 pages, 9 figures; v2: Reference list corrected; v3: Published version, typos corrected, references added
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- 2010
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145. Terrestrial Planet Finder Coronagraph (TPF-C) Flight Baseline Concept
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Levine, Marie, Lisman, D., Shaklan, S., Kasting, J., Traub, W., Alexander, J., Angel, R., Blaurock, C., Brown, M., Brown, R., Burrows, C., Clampin, M., Cohen, E., Content, D., Dewell, L., Dumont, P., Egerman, R., Ferguson, H., Ford, V., Greene, J., Guyon, O., Hammel, H., Heap, S., Ho, T., Horner, S., Hunyadi, S., Irish, S., Jackson, C., Kasdin, J., Kissil, A., Krim, M., Kuchner, M., Kwack, E., Lillie, C., Lin, D., Liu, A., Marchen, L., Marley, M., Meadows, V., Mosier, G., Mouroulis, P., Noecker, M., Ohl, R., Oppenheimer, B., Pitman, J., Ridgway, S., Sabatke, E., Seager, S., Shao, M., Smith, A., Soummer, R., Stapelfeldt, K., Tenerell, D., Trauger, J., and Vanderbei, R.
- Subjects
Astrophysics - Instrumentation and Methods for Astrophysics - Abstract
The Terrestrial Planet Finder Coronagraph (TPF-C) mission presented here is an existence proof for a flagship-class internal coronagraph space mission capable of detecting and characterizing Earth-like planets and planetary systems at visible wavelengths around nearby stars, using an existing launch vehicle. TPF-C will use spectroscopy to measure key properties of exoplanets including the presence of atmospheric water or oxygen, powerful signatures in the search for habitable worlds.
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- 2009
146. Path integral approach to random motion with nonlinear friction
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Baule, A., Cohen, E. G. D., and Touchette, H.
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Condensed Matter - Statistical Mechanics ,Condensed Matter - Materials Science - Abstract
Using a path integral approach, we derive an analytical solution of a nonlinear and singular Langevin equation, which has been introduced previously by P.-G. de Gennes as a simple phenomenological model for the stick-slip motion of a solid object on a vibrating horizontal surface. We show that the optimal (or most probable) paths of this model can be divided into two classes of paths, which correspond physically to a sliding or slip motion, where the object moves with a non-zero velocity over the underlying surface, and a stick-slip motion, where the object is stuck to the surface for a finite time. These two kinds of basic motions underlie the behavior of many more complicated systems with solid/solid friction and appear naturally in de Gennes' model in the path integral framework., Comment: 18 pages, 3 figures
- Published
- 2009
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147. Steady state work fluctuations of a dragged particle under external and thermal noise
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Baule, A. and Cohen, E. G. D.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
We consider a particle, confined to a moving harmonic potential, under the influence of friction and external asymmetric Poissonian shot noise (PSN). We study the fluctuations of the work done to maintain this system in a nonequilibrium steady state. PSN generalizes the usual Gaussian noise and can be considered to be a paradigm of external noise, where fluctuation and dissipation originate from physically independent mechanisms. We consider two scenarios: (i) the noise is given purely by PSN and (ii) in addition to PSN the particle is subject to white Gaussian noise. In both cases we derive exact expressions for the large deviation form of the work distribution, which are characterized by the time scales of the system. We show that the usual steady state fluctuation theorem is violated in our model and that in a certain parameter regime large negative work fluctuations are more likely to occur than the corresponding positive ones, though the average work is always positive., Comment: 22 pages, 17 figures
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- 2009
148. Anomalous fluctuation relations
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Touchette, H. and Cohen, E. G. D.
- Subjects
Condensed Matter - Statistical Mechanics - Abstract
We complement and extend our work on fluctuation relations arising in nonequilibrium systems in steady states driven by L\'evy noise [Phys. Rev. E 76, 020101(R) (2006)]. As a concrete example, we consider a particle subjected to a drag force and a L\'evy white noise with tail index $\mu\in (0,2]$, and calculate the probability distribution of the work done on the particle by the drag force, as well as the probability distribution of the work dissipated by the dragged particle in a nonequilibrium steady state. For $0<\mu<2$, both distributions satisfy what we call an anomalous fluctuation relation, characterized by positive and negative fluctuations that asymptotically have the same probability. For $\mu=2$, by contrast, the work and dissipated work distributions satisfy the known conventional and extended fluctuation relations, respectively, which are both characterized by positive fluctuations that are exponentially more probable than negative fluctuations. The difference between these different fluctuation relations is discussed in the context of large deviation theory. Experiments that could probe or reveal anomalous fluctuation relations are also discussed., Comment: v1: 14 pages, 5 figures, RevTeX format. v2: 12 pages, many changes to the text, close to published version
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- 2009
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149. MA15.09 Ph 2 Trial of IO102-IO103 Vaccine Plus Pembrolizumab: Preliminary Results for the First-line Treatment of Lung Adenocarcinoma
- Author
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Riess, J.W., primary, Cohen, E., additional, Vuky, J., additional, Shaw, P., additional, Rubio, J., additional, Rodriguez, L.M., additional, Chaney, M.F., additional, O'Neill, S., additional, Alavi, A., additional, McDowell, D.O., additional, Ehrnrooth, E., additional, and Garrido, P., additional
- Published
- 2023
- Full Text
- View/download PDF
150. ALLEVIATION OF CARBOHYDRATE COUNTING IN TYPE 1 DIABETES WITH AUTOMATED FASTER ASPART AND PRAMLINTIDE CLOSED-LOOP DELIVERY (ARTIFICIAL PANCREAS): A RANDOMIZED CONTROLLED TRIAL
- Author
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Cohen, E., primary, Tsoukas, M., additional, Legault, L., additional, Yale, J., additional, Von Oettingen, J., additional, Garfield, N., additional, Gouchie-Provencher, N., additional, Odabassian, M., additional, Jafar, A., additional, Ghanbari, M., additional, Rutkowski, J., additional, Palisaitis, E., additional, and Haidar, A., additional
- Published
- 2023
- Full Text
- View/download PDF
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