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The current study aimed to determine the effects of sildenafil-associated aerobic exercise training (ET) on the physical performance, hemodynamic, autonomic and inflammatory parameters of rats. Male Wistar rats were randomly assigned to: sedentary rats placebo-treated (SP); sedentary rats sildenafil-treated (SS); trained rats placebo-treated (TP); and trained rats sildenafil-treated (TS). Sildenafil treatment consisted of 8 weeks of daily oral gavage (1.5 mg/kg), one hour before the session of ET (60-75 % of maximal running speed, 5 days/week, for 8 weeks). After ET period, physical capa city, hemodynamic, autonomic and skeletal muscle inflammatory profile were assessed. Chronic sildenafil treatment causes an additional increase of physical capacity in aerobically trained rats. However, these beneficial effects were accompanied by unwanted alterations, as increased of arterial pressure and peripheral sympathetic modulation, as well as exacerbated inflammatory status on skeletal muscle of rats. Taken together, these data suggest the positive and negative effects of sildenafil chronic administration, associated to aerobic ET, at doses used in clinical practice. This report stresses the importance of paying greater attention to the indiscriminate use of this substance in high-performance sports. [ABSTRACT FROM AUTHOR]

Purpose: The purpose of this study was to compare the acute effects of resistance training (RT) and power training (PT) on the hemodynamic parameters and nitric oxide (NO) bioavailability of older women. Materials and methods: A randomized experimental design was used in this study. Twentyone older women (age: 67.1±4.6 years; body mass index: 28.03±4.9 kg/m2; systolic blood pressure: 135.1±21.1 mmHg) were recruited to participate in this study. Volunteers were randomly allocated into PT, RT, and control session (CS) groups. The PT and RT groups underwent a single session of physical exercise equalized by training volume, characterized by 3 sets of 8-10 repetitions in 8 different exercises. However, RT group performed exercise at a higher intensity (difficult) than PT (moderate) group. On the other hand, concentric contractions were faster in PT group than in RT group. Hemodynamic parameters and saliva samples (for NO quantification) were collected before and during an hour after exercise completion. Results: Results demonstrated post-exercise hypotension during 35 minutes in the PT when compared to rest period (P=0.001). In turn, RT showed decreased heart rate and double product (P,0.001) during the whole evaluation period after exercise completion compared with the rest period. NO levels increased in the PT and RT during the whole evaluation period in relation to rest period. However, there were no differences between PT, RT, and CS regarding hemodynamic and NO evaluations. Conclusion: Data indicate that an acute session of power and resistance exercise can be effective to cause beneficial changes on hemodynamic parameters and NO levels in older women. [ABSTRACT FROM AUTHOR]

Aim To investigate the lifestyles, physical performance and quality of life ( QOL) of frail and robust Brazilian community-dwelling older women, and to identify risk factors for frailty. Methods Frailty was assessed using the Kihon Checklist. Lifestyles were assessed using a questionnaire. Physical performance was assessed by measuring walking speeds, performance on the one-leg stand test and the five-times chair stand test and handgrip strength. QOL was assessed using the Short Form-8 questionnaire. Participants were divided into frail and robust groups based on their total Kihon Checklist scores. Results A total of 109 participants (age 70.8 ± 6.87 years) were included in this study (robust n = 85, frail n = 24). Differences in living structures ( P < 0.001), financial satisfaction ( P = 0.004) and the frequencies with which participants leave the house ( P < 0.001) were found between groups. The frail group had more fallers ( P = 0.047), and lower engagement in physical activity ( P = 0.044), lower body mass indices ( P = 0.043) and poorer nutritional status ( P = 0.002), whereas robust older people showed better physical performance (walking speed P < 0.001, one-leg stand P = 0.021, handgrip strength P = 0.002) and higher QOL scores (general health P = 0.005, role-physical P = 0.013, bodily pain P = 0.002, vitality P = 0.001, social functioning P = 0.001, role-emotional P = 0.008). Multivariate regression analysis identified a slow usual walking speed and bodily pain as risk factors for frailty. Conclusions Frail participants had higher indices for being housebound, and having financial dissatisfaction, a sedentary lifestyle, falls, and malnutrition. Furthermore, they showed poorer physical performance and QOL. An early, well-focused approach is crucial, especially for older adults who walk slowly and have bodily pain to preserve health and QOL. Geriatr Gerontol Int 2016; 16: 829-835. [ABSTRACT FROM AUTHOR]

Aim: Older age is not a homogenous or stereotypical experience. Age-stereotypical representations can often be disconnected from older people's own experiences. Challenging the status quo is relevant for aging well. The aim of this study is to analyze older adults' perspectives on stereotypical versus their own age representations. Method: This qualitative study included a sample of 433 older adults who were 65 to 74, 75 to 84, and 85+ years of age. Content analysis was carried out. Results: Findings from this study indicated that the great majority of the participants (88%) did not identify with stereotypical age representations. This was so among participants in the 65–74 age group in relation to Showing a sense of agency (81.1%); Feeling spiritual (73.4%); Having meaningful goals (72.2%); Holding a significant social network (70.9%); Staying tuned to the world (67.1%); and feeling physically attractive (59.8%). Participants who were 75–84 years of age clarified what physical health (81.0%) and surviving chronic illnesses (78.9%), autonomy (75.5%), being socially active (74.9%), and staying mentally active (70.1%) represent at that age. The +85 years age group drew attention to No pain or physical limitations (95.6%), Physical health (93.1%), Cognitive autonomy (87.1%), Staying tuned to society and the world (76.3%); and Mobility (72.2%). Conclusions: Participants' favoring their own over stereotypical thinking about people their age represents inner resourcefulness and a penchant for aging well. Collaborative partnerships for sharing such wisdom around could enrich policy programs and interventions that favor inclusivity and fight ageism, fostering a more accurate perspective of what it means to be a certain 'age' versus simply being 'old'. [ABSTRACT FROM AUTHOR]

Physical frailty and sarcopenia (PF&S) share multisystem derangements, including variations in circulating amino acids and chronic low-grade inflammation. Gut microbiota balances inflammatory responses in several conditions and according to nutritional status. Therefore, an altered gut-muscle crosstalk has been hypothesized in PF&S. We analyzed the gut microbial taxa, systemic inflammation, and metabolic characteristics of older adults with and without PF&S. An innovative multi-marker analytical approach was applied to explore the classification performance of potential biomarkers for PF&S. Thirty-five community dwellers aged 70+, 18 with PF&S, and 17 nonPF&S controls were enrolled. Sequential and Orthogonalized Covariance Selection (SO-CovSel), a multi-platform regression method developed to handle highly correlated variables, was applied. The SO-CovSel model with the best prediction ability using the smallest number of variables was built using seven mediators. The model correctly classified 91.7% participants with PF&S and 87.5% nonPF&S controls. Compared with the latter group, PF&S participants showed higher serum concentrations of aspartic acid, lower circulating levels of concentrations of threonine and macrophage inflammatory protein 1α, increased abundance of Oscillospira and Ruminococcus microbial taxa, and decreased abundance of Barnesiellaceae and Christensenellaceae. Future investigations are warranted to determine whether these biomediators are involved in PF&S pathophysiology and may, therefore, provide new targets for interventions. [ABSTRACT FROM AUTHOR]

The increasing mental health challenges among elders demand specialized interventions, especially within Thai communities where resources are limited and stigma persists. While monks offer spiritual support, there is a gap in addressing complex mental health needs. This research aims to develop a monk-led elderly mental health counseling program in Thai Buddhist communities. From January 2023 to March 2024, this study underwent four phases. Initially, qualitative interviews with thirty-six monk and elder participants elucidated requirements. The program development integrated findings from the requirement study, the Solution-Focused Brief Therapy process, and Buddhist mindfulness principles to create a prototype. The quality assessment involved expert content validation, feasibility examination by stakeholders, and a small-scale pilot testing with five monks. Finally, the feasibility of the program was assessed with thirty-two monks. The study reveals three key components of the monk-led elderly counseling program focused on mental health: the counseling process known as MPS-MAV-PI (an Introduction to Mindfulness, Identifying Problems, Assessing the Severity, Mindfully Observing Thoughts and Emotions, Acceptance, Visualizing Success, Planning Strategies for Problem-solving, and Implementation and Subsequent Monitoring), the C-TIME strategy (Collaboration, Training Manual, Implementation, the Monitoring, and Evaluation), and the program manual. Moreover, feasibility assessments among monks show the high feasibility of the program for implementation. The monk-led counseling program holds promise in addressing these challenges, with high feasibility indicating potential effectiveness and scalability. Future research will prioritize evaluating its cost-effectiveness and overall effectiveness. [ABSTRACT FROM AUTHOR]

(1) Background: The present work aims to conduct a systematic review and meta-analysis of observational studies, in order to investigate the association of relative protein intake and physical function in older adults; (2) Methods: Observational studies, that investigated the association between protein intake and physical function in older adults, were retrieved from MEDLINE, SCOPUS, CINAHL, AgeLine, EMBASE, and Cochrane-CENTRAL. Two independent researchers conducted study selection and data extraction; (3) Results: Very high protein intake (≥1.2 g/kg/day) and high protein intake (≥1.0 g/kg/day) groups showed better lower limb physical functioning and walking speed (WS) performance, respectively, in comparison to individuals who present relative low protein (<0.80 g/kg/day) intake. On the other hand, relative high protein intake does not seem to propitiate a better performance on isometric handgrip (IHG) and chair rise in comparison to relative low protein intake. In addition, there were no significant differences in the physical functioning of high and middle protein intake groups; (4) Conclusions: In conclusion, findings of the present study indicate that a very high (≥1.2 g/kg/day) and high protein intake (≥1.0 g/kg/day) are associated with better lower-limb physical performance, when compared to low protein (<0.80 g/kg/day) intake, in community-dwelling older adults. These findings act as additional evidence regarding the potential need to increase protein guidelines to above the current recommendations. However, large randomized clinical trials are needed to confirm the addictive effects of high-protein diets (≥1.0 g/kg/day) in comparison to the current recommendations on physical functioning. All data are available in the Open ScienceFramework. [ABSTRACT FROM AUTHOR]

(1) Background: Several factors have been suggested to be associated with the physiopathology of frailty in older adults, and nutrition (especially protein intake) has been attributed fundamental importance in this context. The objective of this study was to conduct a systematic review and meta-analysis to investigate the relationship between protein intake and frailty status in older adults. (2) Methods: A search of scientific studies was conducted in the main databases (Medline, Scopus, Cochrane library), and in the reference lists of selected articles. The search terms included synonyms and Medical Subject Headings and involved the use of Boolean operators which allowed the combination of words and search terms. Observational studies—cross-sectional and longitudinal—that met the eligibility criteria were included in the review. Article selection and data extraction were performed by two independent reviewers. Meta-analyses with random effects were performed. Publication bias was measured using the Strengthening the Reporting of Observational Studies in Epidemiology instrument. (3) Results: In the final sample, 10 articles, seven cross-sectional and three longitudinal, were included in the present study. Overall, studies investigated a total of 50,284 older adults from three different continents between 2006 and 2018. Four cross-sectional studies were included in the meta-analyses. The results demonstrated that a high protein intake was negatively associated with frailty status in older adults (odds ratio: 0.67, confidence interval = 0.56 to 0.82, p = 0.0001). (4) Conclusions: Our findings suggest that a high consumption of dietary protein is inversely associated with frailty in older adults. [ABSTRACT FROM AUTHOR]