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Polymorphic genes involved in the regulation of lipid metabolism may be responsible for interindividual differences in efficiency of hypolipidaemic therapy. In the present prospective and randomised study, we investigated the efficacy of rosuvastatin (10 mg/day) in lipid-lowering therapy in 62 patients with coronary artery disease (CAD) possessing different genotypes of lipoprotein lipase (LPL) gene

The aim of this study was to investigate the association between functional polymorphism C677T (rs1801133) of methylenetetrahydrofolate reductase (MTHFR) gene for and risk of peripheral artery disease in diabetes patients

Alterations in structural and functional properties of the cell membrane may represent diseaseassociated intermediate phenotypes reflecting the mechanisms of essential hypertension. The study was designed to assess the effects of polymorphisms in genes associated with EH on the variation of erythrocyte membrane proteins in hypertensive patients

Uterine hyperplastic processes such as of endometrium, uterine leiomyoma, genital endometriosis are mostly common pathological conditions among gynaecological diseases. The disorders have shared pathogenetic mechanisms and may be diagnosed in combinations

The aim of this study was to investigate the association between functional polymorphism 640A>G (rs1049255) of the CYBA (cytochrome b-245, alpha polypeptide of NADPH oxidase) gene and the risk of uterine myoma

Article concerns data of the bio-informational analysis of polymorphic options of genes at patients with endometrial hyperplasia and women in control group

The relationship between polymorphic variants of folate metabolism genes with clinical (blood pressure level before and at the end of pregnancy) and clinical and laboratory indicators (proteinuria, fibrinogen, total protein, urea and creatinine in the blood, activated partial thromboplastin time, thrombin time) were studied in pregnant women with preeclampsia

This paper presents the results of the study of the interrelationships of polymorphic loci of chemokines (rs1719153, rs4512021, rs2107538, rs2857657, rs1801157) with features of humoral immunity in patients with chronic glomerulonephritis

To study the association of genetic polymorphisms of coagulation factors with clinical and laboratory indicators in pregnant women with placental insufficiency with fetal growth retardation

Study concerns data of the bioinformative analysis of polymorphic options of genes at patients with hysteromyoma and women in control group. There were determined combinations genetic variations CC F13A1 with A FTO (OR=1.55), C F13A1 with CC CNVs (OR=1.58), G FTO with A KDM3B and C CNVs (OR=1.38) with hysteromyoma developing in the women of Russia Central Region

The associations of the insertion-deletion angiotensin-converting enzyme (I/D ACE) genetic polymorphism with the risk of preeclampsia development were studied

The article presents the results of studying the relationship of polymorphic variants of chemokine genes (1931A/T CCL4, A/G CXCL11 (rs4512021), - 403A/G CCL5, C/G CCL2 (rs2857657), - 801G/A CXCL12) with the features of clinical manifestations of chronic glomerulonephritis

The aim of the research was to study part of combination of genes rs2241423, rs12444979 and rs6732220 among Russia Central Chernozem region population

Expression mRNA of indoleamine 2,3-dioxygenase (IDO) and Toll-like receptors (TLR) 1-4 in epithelial cells of cervix uteri in 57 patients with early stage miscarriages (6-10 weeks of pregnancy) and 57 patients with artificial abortion (control group) was examined using quantitative polymerase chain reaction (PCR)

The aim of the research was to study the role of the combinations of the genes rs6729809 and rs10769908 in the formation of hyperplastic processes of uterus among the population of the Central Chernozem region of Russia

The objective of the research was a bioinformatic study of the involvement of candidate genes in the formation of a combination of endometriosis with uterine myoma in women

A total of 1613 Russian females were recruited for the study. Fifty two polymorphisms were analyzed for their association with AAM, height, and BMI

This paper presents the results of bioinformatic analysis of three polymorphic loci in 170 women who suffer from a combination of uterine fibroids with endometrium hyperplastic processes and in 981 women of the control group without proliferative diseases of pelvic organs

Enzymes CYP4A11 and CYP4F2 are involved in biosynthesis of vasoactive 20-hydroxyeicosatetraenoic acid and may contribute to pathogenesis of coronary artery disease (CAD). We investigated whether polymorphisms of the CYP4A11 and CYP4F2 genes are associated with the risk of CAD in Russian population. In silico analysis allowed identifying that SNP rs9332978 is located at a binding site for multiple transcription factors; many of them are known to regulate the pathways involved in the pathogenesis of CAD

This study investigated whether common polymorphisms of cytochrome P450 2J2 (CYP2J2), a major enzyme that controls the biosynthesis of vasoactive epoxyeicosatrienoic acids, are collectively involved in the molecular basis of essential hypertension (EH). The bioinformatic analysis enabled identification of the SNPs that possess regulatory potential and/or are located within the binding sites for multiple transcription factors that play roles in the pathways involved in hypertension pathogenesis

Epoxyeicosatrienoic acids (EETs) are important vasoactive products of arachidonic acid metabolism with a wide range of biological actions in the cardiovascular system. The present study investigated whether single nucleotide polymorphisms of genes coding cytochrome P450 2C subfamily, enzymes involved in biosynthesis of EETs, are associated with the risk of coronary heart disease

The present study was designed to investigate whether genetic polymorphisms of the aryl hydrocarbon receptor (AHR) signaling pathway are involved in the molecular basis of essential hypertension (EH)

The aim of this study was to examine the role of hereditary thrombophilia in the development of fetal growth retardation (FGR) in the population of Central Russia

We sequenced the genomes of a 7,000-year-old farmer from Germany and eight 8,000-year-old hunter-gatherers from Luxembourg and Sweden. We analysed these and other ancient genomes¹-₄ with 2,345 contemporary humans to show that most present-day Europeans derive from at least three highly differentiated populations:west European hunter-gatherers, who contributed ancestry to all Europeans but not to Near Easterners; ancient north Eurasians related to Upper Palaeolithic Siberians³, who contributed to both Europeans and Near Easterners; and early European farmers, who were mainly of Near Eastern origin but also harboured west European hunter-gatherer related ancestry.We model these populations’ deep relationships and show that early European farmers had 44% ancestry from a ‘basal Eurasian’ population that split before the diversification of other non-African lineages

This paper presents the results of bioinformatic analysis of five molecular genetic markers of 947 women with uterine hyperplasia and 988 women of the control group

The article outlines the role of cytokines in development of genital endometriosis. There were detected associations between genetic polymorphisms and their combinations and development of genital endometriosis among women in the Central region of Russia

Gene encoding flavin-containing monooxygenase 3 (FMO3), a microsomal antioxidant defense enzyme, has been suggested to contribute to essential hypertension (EH). The present study was designed to investigate whether common functional polymorphism E158K (rs2266782) of the FMO3 gene is associated with EH susceptibility in a Russian population. A total of 2 995 unrelated subjects from Kursk (1 362 EH patients and 843 healthy controls) and Belgorod (357 EH patients and 422 population controls) regions of Central Russia were recruited for this study

N-acetyltransferase (NAT2) is a phase-II xenobiotic-metabolizing enzyme participating in the detoxification of toxic arylamines, aromatic amines and hydrazines. The present study was designed to investigate whether two common single-nucleotide polymorphisms (SNP) of the NAT2 gene (481C>T, rs1799929; 590G>A, rs1799930) are associated with susceptibility to idiopathic male infertility and to assess if the risk is modified by oxidant and antioxidant exposures. A total 430 DNA samples (203 infertile patients and 227 fertile men) were genotyped for the polymorphisms by PCR and restriction fragment length polymorphism. No association was found between the NAT2 polymorphisms and idiopathic male infertility

The authors investigated associations of polymorphism of interleukins genes with nephritic survivance of the ill with chronic glomerulonephritis among 238 patients with CGN and 241 control group individuals

The article presents study of cytokines molecular genetic markers’ impact on nature of uterus affection with myomatous knots

The authors researched associations of chemokines genes polymorphisms with parameters of humoral immunity of 238 patients with chronic glomerulonephritis and 462 individuals of a control group

Results from studying Y chromosomal polymorphisms of Russian and Ukrainian populations are presented for Slobozhanshina, which is a contemporary border region, inhabited in the 17th–18th centuries at the “Wild Field” boundary due to migrations of both the Russians from the north and Ukrainians from the west. In general, the Ukrainian and Russian populations of Slobozhanshchina are very close genetically; their set and frequency range of Y chromosome haplogroups are typical for Eastern Europe. However, a detailed analysis of highly informative Y chromosome markers showed that both nations retain the ethnic specificity of their gene pools after 3.5 centuries of coexistence in the same historical territory: the Ukrainian popula tions are similar to the rest of Ukraine, and Russian populations gravitate towards the south of European Rus sia. The persistent genetic differences may be due to the spatial characteristics of marriage migration and the predominant ethnic environment, Belgorod State National Research University

The study was designed to assess the effects of polymorphisms in genes associated with essential hypertension on the variation of erythrocyte membrane proteins (EMPs) in hypertensive patients, Belgorod State National Research University

Here, we characterize genetic variation in all extant ethnic groups speaking Balto-Slavic languages by analyzing mitochondrial DNA (n = 6,876), Y-chromosomes (n = 6,079) and genome-wide SNP profiles (n = 296), within the context of other European populations. We also reassess the phylogeny of Slavic languages within the Balto-Slavic branch of Indo-European. We find that genetic distances among Balto-Slavic populations, based on autosomal and Y-chromosomal loci, show a high correlation (0.9) both with each other and with geography, but a slightly lower correlation (0.7) with mitochondrial DNA and linguistic affiliation, Belgorod State National Research University

The characteristics of the gene pools of indigenous populations of Ukraine and Belarus have been studied using 28 alleles of 10 loci of biochemical gene markers (HP, GC, TF, PI, C'3, ACP1, GLO1, PGM1, ESD, and 6-PGD). The gene pools of the Russian and Ukrainian indigenous populations of Belgorod oblast (Russia) and the indigenous populations of Ukraine and Belarus have been compared

Data on the frequencies of all (50412) surnames in a total population of 849399 people have been treated by various methods of multivariate statistics (cluster analysis, multidimensional scaling, and factor analysis) to show that 22 district populations of the Central Chernozem region of Russia form a definite, ordered system of population groups

The frequencies of 33 alleles of 12 loci of immunological and biochemical gene markers (AB0, RH, HP, GC, TF, PI, C'3, ACP1, GLO1, PGM1, ESD, and 6-PGD) have been estimated in the indigenous Russian and Ukrainian populations of Belgorod oblast

The model of the Belgorod oblast population has been used to demonstrate different effects of administrative reforms on microevolution in human populations. For the populations that formerly belonged to Kursk oblast, changes in the regional administrative structure have lead to an increase in the genetic distances between them

The frequencies and spectra of surnames have been analyzed in groups of raions (districts) of the Belgorod oblast (region) with different degrees of population subdivision. The “family name portraits” of districts with low and moderate inbreeding levels are similar both to each other and to the “family name portrait” of the Belgorod oblast as a whole

The gene pool of the entire population of all the 21 raions (districts) of the Belgorod oblast (region) has been studied using anthroponymic data. Considerable geographic variations of the number of surnames and the degree of population subdivision in the 21 districts have been demonstrated

Changes in the endogamy indices of district populations of the Central Chernozem region of Russia during the past 100 years were studied. The size of an elementary population in this region increased from that of a rural municipality in the mid-20th century to that of an administrative district in the late 20th century

It has been proposed that the D 32 mutation in the chemokine receptor gene, inducing resistance to HIV-1 and, probably, to other virus infections, has undergone selection in historical times. The frequency of this mutant allele has changed rapidly both in time (during the last two millennia) and in space (across Eurasia)

Progress in the mapping of population genetic substructure provides a core source of data for the reconstruction of the demographic history of our species and for the discovery of common signals relevant to disease research