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Objectives Chronic rhinosinusitis (CRS) is common disease in otorhinolaryngology and will lead to lower airway abnormality. However, the only lung function in CRS patients and associated factors have not been much studied. Methods One hundred patients with CRS with nasal polyps (CRSwNP group), 40 patients with CRS without nasal polyps (CRSsNP group), and 100 patients without CRS were enrolled. The difference in lung function was compared. Meanwhile, CRSwNP and CRSsNP group were required to undergo a bronchial provocation or dilation test. Additionally, subjective and objective outcomes were measured by the visual analogue scale (VAS), 20-item Sino-Nasal Outcome Test (SNOT-20), Lund-Mackay score, Lund-Kennedy endoscopic score. The correlation and regression methods were used to analyze the relationship between their lung function and the above parameters. Results The forced expiratory volume in 1 second (FEV1) and forced expiratory flow between 25% and 75% of forced vital capacity (FEF25-75) of CRSwNP group were significantly lower than other groups (P

The medicinal plant resource reserve refers to the natural resources of medicinal plants in a certain time and a certain region within the scope of the volume. In recent years, with the demand of medicinal plant resources surging and the change of the environment and human intervention factors, the medicinal plant resources reserve had accelerated pace of change. It is the prerequisite and basis for the development and utilization of medical plants that how to quickly and accurately attain reserve of some medicinal plants resources, the selection of suitable and accurate estimating method is reliable basis and can guarantee medicinal plant reserve survey, and also is one of the key reserve investigation of success. This paper systematically summarized the estimation method of medicinal plants in recent 30 years, and discussed the basic principle, the estimation model of development and evolution, advantages and disadvantages and applicability, and it aimed to improve the accuracy about reserves survey of medicinal plant resources, and provide scientific and reliable support data to medicinal plants resources for sustainable development and utilization of resources.

This study was conducted to identify chemicals in root exudates and their effect on Rhizoctonia solani in potato cropping systems. Root exudates were collected from the fields with 5 years of continuous potato cropping in comparison with rotational cropping of potato and other crops, using in-house made root boxes at the seedling and squaring stages. Chemicals in the root exudates were identified using the GC-MS method. The results showed that glucide concentration was the highest in the root exudates, followed by organic acids. Compared with the rotational cropping, the continuous cropping significantly decreased the glucide content and increased the content of organic acids in the root exudates. The contents of almitic acid in root exudates under continuous cropping was 0.94% at seedling stage and 1.4% at squaring stage, the dibutyl phthalate was 0.15%, whereas under rotational cropping, those values were decreased to 0.15%, 0.2%, and being negligible, respectively. The root exudates promoted the growth of R. solani, especially under continuous potato cropping. The simulation test showed that the palmitic acid and dibutyl phthalate in root exudates could promote the growth of R. solani.

Mongolian folk medicine resource is the origin of Mongolian medicine development, even more important of which is the specialized Mongolian folk medicine resources with regional and high medicine quality, it processes distinctive national characteristics with irreplaceable important position in traditional Mongolian medicine. Nevertheless, due to the serious destroy of ecological environment and sharp increase of demands, etc. A lot of specialized Mongolian folk medicine resources were endangered, and there still existed some problems in the protection and exploitation and utilization. This paper intends to provide comprehensive insight into the species protection and exploitation and utilization states of specialized Mongolian folk medicine resources. The application and protection status and the existing problems were reviewed, and the development strategies of Mongolian folk medicine resource were analyzed.

Lomatogonium rotatum (L.) Fries, Gentianopsis barbata (Froel) Ma, and Gentianella acuta (Michx.) Hulten, the three kinds of Digeda-species Mongolian medicinal materials belonging to the family Gentianaceae, bad been widely used for the treatment of liver diseases. To analyze comparatively the content of swertiamarin and swertisin among these three kinds of Digeda-species Mongolian medicinal materials. HPLC method was applied for qualitative and quantitative analysis of swertiamarin and swertisin. The Phenomenex C18 (4.6 mm x 250 mm, 5 μm) was used, chromatographic methanol and water as mobile phase, the flow rate was 1.5 mL x min(-1) with UV detected at 237 nm, column oven temperature was 25 degrees C. Results showed that the contents of swertiamarin and swertisin were closely related the different species and producing areas. The content range of swertiamarin in L. rotatum from different habitats was 1.73% - 2.72%, 0.43% - 0.96% for the swertisin content; the content of swertiamarin in G. barbata from Alxa Left Banner was 0.38%, and the content of swertiamarin and swertisin in G. barbata from the others habitats and G. Acuta from different habitats were all detected qualitatively. The contents of swertiamarin and swertisin among these medicinal plants showed a significant difference due to the different species and producing areas. As a consequence, these medicinal plants should not be put together for clinical applications.

The distribution information of Cistanche deserticola was collected by interview investigation and field survey, and 55 related environmental factors were collected, the habitat suitability study was conducted based on geographic information system (GIS) and Maximum entropy model. The AUCs of ROC curve were both above 0.9, indicating that the predictive results with the maxent model were highly precise. The results showed that 14 major environmental factors have obvious influence on ecology suitability distributions of C. deserticola, including vegetation type et al, the suitable distribution areas are mainly concentrated in the central of Alxa Youqi, the north of Alxa Zouqi and the south-east of Ejin Banner, including Tamusu towns, Alateng towns et al, The zoning results basically coincide with the genuine producing areas, and further afford new suitable distribution areas, which can provide reference for the siting of introduction and cultivation of C. deserticola.

The distribution information of Lomatogonium rotatum. was collected by interview investigation and field survey, and 55 related environmental factors were collected, the habitat suitability study was conducted based on geographic information system (GIS) and maximum entropy model. The AUCs of ROC curve were both above 0.99, indicating that the predictive results with the maximum model were highly precise. The results showed that 13 major environmental factors have obvious influence on ecology suitability distributions of L. rotatum, including month average temperature of February et al., the suitable distribution areas are mainly concentrated in the east-central of Inner Mongolia, including Hexigten banner, Duolun county, Zhenglan banner et al., The zoning results basically coincide with the genuine producing areas, and further afford new suitable distribution areas, which can provide reference for L. rotatum's wild nursery and the siting of introduction and cultivation.

Voriconazole is a second generation triazole antifungal agent and the first choice therapy for invasive aspergillosis (IA). Although voriconazole may be associated with many adverse events, hyponatremia has been rarely reported which potentially could result in death. Therapeutic drug monitoring (TDM) and individualization of therapy by measuring voriconazole plasma concentrations improved the efficacy and safety in patients. We report the effect of TDM to adjust voriconazole dosage in a voriconazole-related hyponatremia patient.

To observe the clinical efficacy of acupuncture at Hegu (LI 4) on central facial nerve paralysis after ischemic stroke, and explore dose-effect relationship among different stimulation intensities of acupuncture at Hegu (LI 4) as well as its optimal treatment plan.According to different acupuncture stimulation intensities which were based on treatment time and needle insertion direction, fifty patients were randomly divided into a Hegu 1 group, a Hegu 2 group, a Hegu 3 group, a Hegu 4 group and a control group, ten cases in each one. Different stimulation intensities of acupuncture at Hegu (LI 4) combined with facial paralysis acupoints, including Yingxiang (LI 20), Dicang (ST 4), Jiache (ST 6) and Quanliao (SI 18), were applied in Hegu 1 to 4 groups; meanwhile acupuncture at stroke acupoints, including Neiguan (PC 6), Shuigou (GV 26) and Sanyinjiao (SP 6), and medication treatment were adopted. Except acupuncture at Hegu (LI 4), the treatment of the control group was identical as Hegu groups. The treatment duration lasted for 14 days. The House-Brackmann facial never grading systems (H-B), Toronto facial grading system (TFGS), degrees of facial never paralysis (DFNP), facial disability index (FDI) and clinical efficacy were compared among groups.(1) Compared before the treatment, H-B, TFGS, DFNP and physical function score in FDI were all improved significantly in the Hegu 1 to 4 groups (all P0.05), but social function score in FDI was not obviously improved (all P0.05); all the scores in the control group were not evidently changed (all P0.05). (2) Compared with the control group, differences of H-B before and after treatment in the Hegu 1 to 4 groups, differences of TFGS in the Hegu 2 group and differences of DFNP in the Hegu 1 and Hegu 2 group were significantly improved (all P0.05). The differences of any scale among Hegu 1 to 4 groups were not significant (all P0.05), in which the most evident change was found in Hegu 2 group. (3) The total effective rate was 90.0% (9/10), 100.0% (10/10), 90.0% (9/10) and 80.0% (8/10) in Hegu 1 to 4 groups, which were significantly higher than 60.0% (6/10) in the control group (all P0.05).Acupuncture at Hegu (LI 4) has affirmative clinical efficacy on central facial nerve paralysis after ischemic stroke, in which oblique insertion along the opposite direction of meridian for 5 s of twirling manipulation has the best clinical effect.

Traditional Mongolian medicine Digeda processes a significant importance in clinical therapy with notably actions of heat-clear and detoxication effects. This paper intends to provide comprehensive insight into the species textual research, chemical constituents, qualitative identification, pharmacology and clinical application of Mongolian medicine Digeda to provide valuable data for further studies and the development of clinical applications of these medicinal plants.

To explore the new method of discriminating Astragali Radix and Hedysari Radix by using PCR amplification of specific alleles, 30 samples of the different Astragali Radix materials and 28 samples of Hedysari Radix were collected. The total DNA of all samples were extracted, trnL-trnF sequence from Astragali Radix and Hedysari Radix was amplified by PCR and sequenced unidirectionally. These sequences were aligned by using Clustul W. Primer was designed and the PCR reaction systems including annealing temperature, dNTP, etc were optimized. All samples were amplified by PCR with specific primer, DNA from Astragali Radix would be amplified 136 bp, whereas PCR products from all of Hedysari Radix were 323 bp. This method can detect 10% of intentional Hedysari Radix DNA into Astragali Radix. PCR amplification of alleles can be used to identify Astragali Radix and Hedysari Radix successfully and is an efficient molecular marker for authentication of Astragali Radix and Hedysari Radix.

Allopurinol is a popular and widely-prescribed anti-hyperuricemic agent that has been implicated in drug interactions with substrates of several cytochrome P450 (CYP) enzymes. The effect of repeated allopurinol administration (20 mg/kg, once daily for 14 days) on metabolic activity of CYP was assessed in rats. This was a randomized, double-blind, two-way crossover study with a 4-week washout period between phases. The substrates used in this study were phenacetin (CYP1A2), tolbutamide (CYP2C9), omeprazole (CYP2C19) and dextromethorphan (CYP2D6). Validated HPLC-MS/MS was used to quantify all compounds. Our study showed that allopurinol administration inhibited CYP1A2 activity, causing a significant increase in AUC (0-infinity) (P0.01) and t1/2 (P0.05) of phenacetin, and a distinct decline in CL (P0.01). However, there were no significant differences of another three probe drugs in plasma concentrations and the corresponding pharmacokinetic parameters between the allopurinol-treated and normal saline-treated rats. The findings in this study suggested that allopurinol could inhibit CYP1A2 but did not influence CYP2C9, CYP2C19 and CYP2D6 enzymes.

In 2010, a field experiment with potato (Solanum tuberosum) cultivar 'Xindaping' was conducted at the Dingxi Extension Center of Gansu Province, Northwest China, aimed to understand the accumulation and distribution patterns of dry matter (DM) and potassium (K) in the organs of potato plant in semi-arid rainfed areas. During the whole growth period of the cultivar, the DM accumulation in root, stem, and leaf all showed a unimodal curve, with the DM accumulation rate being leafstemroot, whereas the DM accumulation in whole plant and tuber was an S-curve. The maximum DM accumulation rate of the whole plant was higher than that of the tuber, and appeared 17 days earlier. The distribution of DM in different organs showed two turning points, i.e., during the tuber formation (TF) period and the tuber growth (TG) period. During TF period, the DM accumulation was the greatest in leaf, followed by in tuber. The TF period was also the DM balance period, which occurred 90 days after emergence. Before the DM balance period, the DM accumulation in tuber was lesser than that in root, stem, and leaf, and there was a positive correlation between the DM accumulation in tuber and in root, stem, and leaf. However, after the DM balance period, the DM accumulation in tuber was greater than that in root, stem, and leaf, and the correlation was negative. At seedling stage and in TF period, TG period, starch accumulation period, and maturity period, the DM accumulation in whole plant was 5%, 30%, 60%, 4% , and 1%, while that in tuber was 0,18% , 62 , 18% , and 2%, respectively. In the whole growth period, more than 50% of the DM was formed in TG period. The K concentration was the highest in stem and the lowest in tuber, though the K was mostly concentrated in root before the DM balance period. The K accumulation before the DM balance period was mostly in root, stem, and leaf, with the sequence of stemleafroot, but after the DM balance period, the K was mainly allocated in tuber, with60% of the K accumulated in tuber in maturity period.

Voriconazole is a broad-spectrum triazole antifungal agent and the first-choice therapy for invasive aspergillosis (IA) ([1][1]). Although voriconazole is generally well tolerated, anecdotal case reports have described unexpected severe adverse events related to voriconazole, such as hyponatremia

Continuous cropping obstacle is one of the main restriction factors in potato industry. In order to explore the mechanisms of potato's continuous cropping obstacle and to reduce the impact on potato's tuber yield, a field experiment combined with PCR-DGGE molecular fingerprinting was conducted to investigate the fungal population structure and its biological effect in rhizosphere soil of continuously cropped potato. With the increasing year of potato' s continuous cropping, the numbers of visible bands in rhizosphere fungal DGGE profiles increased obviously. As compared with that of CK (rotation cropping), the operational taxonomic unit (OTU) in treatments of one to five years continuous cropping was increased by 38.5%, 38.5%, 30.8%, 46.2%, and 76.9% respectively, indicating that potato's continuous cropping caused an obvious increase in the individual numbers of dominant fungal populations in rhizosphere soil. Also with the increasing year of potato's continuous cropping, the similarity of the fungal population structure among the treatments had a gradual decrease. The sequencing of the fungal DGGE bands showed that with the increasing year of continuous cropping, the numbers of the potato's rhizosphere soil-borne pathogens Fusarium oxysporum and F. solani increased obviously, while the number of Chaetomium globosum, as a biocontrol species, had a marked decrease in the fifth year of continuous cropping. It was suggested that potato' s continuous cropping caused the pathogen fungal populations become the dominant microbial populations in rhizosphere soil, and the rhizosphere micro-ecological environment deteriorated, which in turn affected the root system, making the root vigor and its absorption area reduced, and ultimately, the tuber yield decreased markedly.

To explore the brain natriuretic peptide (BNP) on prognostic value in patients with viral myocarditis.A total of 48 patients with viral myocarditis and 42 healthy people were enrolled and followed up for two years. The NYHA class and LVEF were recorded and the concentration of BNP were measured.The concentration of BNP were higher and EF were lower in patients with viral myocarditis (P0.01) than contrast people. Higher levels of plasma BNP were related to higher mortality.Levels of brain natriuretic peptide measured in the plasma could be a useful biochemical marker for the myocarditis, and high concentration of BNP may correlate with poor prognosis in patients with myocarditis.

To evaluate the efficacy and safety of radix astragali and its compound prescription for treatment of β-thalassemia in children.This study was a randomized, controlled, double-blind clinical trial. Fifty-seven children with β-thalassemia were randomly assigned to radix astragali, compound prescription (radix astragali+ codonopsis pilosula + tortoise plastron) and placebo control groups after stratifying the patients according to disease type (intermedia and major). The parameters of hematology and safety were assessed after 12 weeks of treatment.After 12 weeks of treatment, the mean Hb elevation levels in children with β-thalassemia intermedia from the compound prescription and the radix astragali groups were 1.21±1.12 and 1.05±0.80 g/dL respectively compared with -(0.28±0.51) g/dL in the placebo control group (P0.01). Mean Hb levels in the compound prescription and radix astragali groups were significantly higher than in the placebo control group (P0.05). Therapy with both radix astragali and its compound prescription increased fetal hemoglobin, red blood cell, mean corpuscular hemoglobin and reticulocyte levels in children with β-thalassemia intermedia. The total effective rates were 64% and 62% in children with β-thalassemia intermedia from the compound prescription and radix astragali groups respectively, which was significantly higher than in the placebo control group (9%; P0.01). Therapy with radix astragali or its compound prescription in children with β-thalassemia major had similar but less favourable effects than the same therapy in children with β-thalassemia intermedia. White blood cell, neutrophil, platelet and hepatic and renal functions were not adversely affected by the medicines.Therapy with radix astragali or its compound prescription is effective and safe in children with β-thalassemia.

Based on decades of research from Chinese ancient medical classics, with new understandings of the meridian differentiations, the academician SHI Xue-min made a further research on the original intention of the "syncope" of Miraculous) Pivot: Meridians. Furthermore, due to his clinical practice, the specific applications were summarized to guide the clinical treatment, such as the locations of acupoints and the techniques of acupuncture, which could be evidenced by favorable therapeutic improvements.

To assess the efficiency of the PDL in the treatment of PWS in Chinese patients with skin type III-IV.252 patients with PWS at different anatomical sites were retrospectively studied. A flashlamp-pumped pulsed dye laser was used. The differences in therapeutic effect of laser were analyzed in the following ways: (1) by dermatomal distribution of face and neck; (2) by anatomical subdivision of face; (3) by the size of the lesion. The therapeutic effect was graded as 0or = poor25%, 25%or = fair50%, 50%or = good75%, 75%or = excellentor = 100%.It revealed that the lesions at neck had the best response. The dermatome II zone showed the least response to PDL. Among the anatomical subdivision of face, the frontal area had the highest clearance, while the zygoma and cheek had the lowest clearance. Patients with PWS on the extremities respond less favorably with the fair lightening effect. Furthermore, the mean lightening was decreased as the size of PWS was increased.The response difference of PWS to PDL was not only related to the anatomical region, but also related to the lesion size. It is imperative to give the patients rational treatment suggestion and normal expectation.

The Web of Things (WoT) is a refinement of the Internet of Things by integrating heterogeneous devices not only into the Internet (the network), but into the Web (the application layer). With the expansion of applications and devices, WoT Gateway Middleware is bearing more and more pressure from data processing, and therefore the WoT gateway middleware takes more time to respond to the requests of applications. A data collecting and caching mechanism is an effective solution to this problem. In this paper, we begin by describing the gateway middleware architecture with the focus on data collecting and caching functionality. Then the data collecting and caching (DCC) functionality module is discussed in detail. The DCC module supports three kinds of data collecting and caching modes: fundamental mode, configurable mode and adaptive mode. We finally demonstrate how these three modes work. A SMART HOME system is developed as the implementation to verify and discuss the proposed mechanism.

A mobile application meets the highly real-time requirement for data in sensor networks. However mobile applications have to handle many difficulties that do not exist in non-mobile environment. For example, the wireless network provided for mobile is slow, expensive and bandwidth-limited. So mobile application cannot acquire sensor data like a common application does, which will consume a large share of bandwidth, CPU and memory. To address this issue, we propose our design that will limit the concurrently acquisition of the sensor data with a self-adapting mechanism. It can lower the overhead of the system significantly and whats more, it hardly reduces the user experience even in the situation that the total acquisition frequency is limited.

Cyanoethylated secondary fiber (CSF) were made from secondary fiber(SF) cyanoethylation，and the effect of cyanoethylation on SF and CSF/RHDPE composites were investigated. The reinforcing mechanism of CSF in composites was discussed. Compared with unmodifed fiber, modifed fiber improved interfacial compatibility between CSF and RHDPE, and resulted in enhancing the mechanical properties of CSF/RHDPE composites. Furthermore, The fibre mass fraction and nitrogen content of CSF affected the mechanical properties of CSF/RHDPE composites, When nitrogen content of CSF was 20.36% and content of CSF was 20wt%, composites show maximum mechanical properties. The influence degree of CSF addition on CSF/RHDPE composites' processability was smaller than SF/RHDPE composites. CSF weakened melting and crystallization properties of the RHDPE in the composites. The mechanical properties of CSF/RHDPE composites were better than those of SF/RHDPE. SEM observations on the fracture surface of the composites show that the fibre-matrix adhesion was improved after cyanoethylation treatments.

The biodegradable composites made from secondary fiber(SF) and cyanoethylated secondary fiber(CSF) were prepared by press forming, and the effect of alkali pretreatment and combined pretreatment of alkali and silane coupling agent KH550 on secondary fiber and composites were investigated. The optimum content of SF is 10 wt% because the hot melt viscosity of CSF was higher than that of traditional thermoplastic resins，and interfacial adhesion strength between SF and CSF is weak. Alkali pretreatment and combined pretreatment of alkali and silane coupling agent KH550 on secondary fiber results in enhancing the mechanical of composites. Furthermore, compared with alkali pretreatment, composites reforced with combined pretreated of alkali and silane coupling agent KH550 SF show better mechanical properties，because of combined effect alkali and silane coupling agent KH550 resulting in improving interfacial adhesion strength between SF and CSF.

To study the therapeutic effect, safety and risk of fractional resurfacing with ablative laser in the treatment of superficial scar.88 cases of superficial scar, including 66 cases of acne scar, 12 cases of burn scar and 10 cases of other scar, were treated. All the patients were treated with Pixel (Er:YAG 2940 nm,or = 3 times), or Encore (Ultrapulse CO2 10600 nm,or = 2 times), or a combination of Pixel and Encore(or = 3 times).The therapeutic effect of treatment was graded as medium when the scar was improved25%, as good when the scar was improved50%. The effective result was achieved in 80% of the patients. Good effect was achieved in 50% of the patients. There were 244 treatments of Pixel and 86 treatments of Encore. Persistent hyperpigmentation was happened in one case with Encore treatment, which relieved four months later. No other complication was happened.The fractional resurfacing with ablative laser is an effective method for superficial scar, especially acne scar. It is mini-invasive with low risk. The key mechanism is the ability of enhancing the tissue remodeling induced by heat effect of laser.

Over the past several decades, interest in environmental pollutants abatement has greatly increased. This interest is derived from growing concern about environmental pollution and the serious deterioration of many ecosystems as a result of environmental pollution. NTPs chemistry is a proven and effective tool both for decomposing a range of pollutants and for cleaning contaminated surfaces. NTPs chemistry has crucial advantages such as high energy efficiency, higher treatment effectiveness, effective treatment in more confined spaces, and near zero-emissions. When NTPs chemistry is combined with the use of certain catalysts, synergetic pollution abatement results may be achieved; however, the mechanism by which the synergy occurs is still unclear. The purpose of this paper is to provide a basic understanding of NTPs chemistry, including the commonly employed chemical mechanisms, examples of NTPs chemistry applications, and an opinion on the future for NTPs chemistry in the field of environmental pollutants abatement.

To investigate the role of CD4+CD25+Foxp3+ regulatory T cells (Treg) in type 2 diabetic nephropathy and provide new clues for prevention and treatment of type 2 diabetic nephropathy.Flow cytometry was used to analyze the expression rate of CD4+CD25+Foxp3+ Treg cells in 60 patients with type 2 diabetes and 15 normal subjects.No significant difference was found in the expression rate of CD4+CD25+Foxp3+ Treg cells between the control group and the type 2 diabetic patients. In the type 2 diabetic patients with microalbuminuria and macroalbuminuria, the expression of CD4+CD25+Foxp3+ Treg cells was significantly lowered in comparison with that in the control group (P0.05), and patients with macroalbuminuria showed significantly lower expression of CD4+CD25+Foxp3+ Treg cells than the microalbuminuric patinets (P0.05). Significant inverse correlations were noted between the disease course and the expression of CD4+CD25+Foxp3+ Treg cells and between the urinary albumin excretion rate (UAER) and the expression of CD4+CD25+Foxp3+ Treg cells.CD4+CD25+Foxp3+ Treg cells may play a role in the occurrence and development of type 2 diabetic nephropathy.

The title compound, C(16)H(22)O(3), is a useful inter-mediate in the synthesis of poly(amido-amine) dendrimers. The cyclo-hexane ring adopts a chair conformation. In the crystal structure, mol-ecules are linked into centrosymmetric dimers by pairs of O-H⋯O hydrogen bonds.

For the special bistatic space based radar system which is composed of an illuminator on a geostationary satellite and a receiver on an airship, the analysis to the signal-to-noise ratio (SNR) is very important for the realization of detecting capability to moving targets. In this paper, based on the practical receiver platform coordinate frame and the spherical-earth assumption, the method of SNR calculation is first introduced, then the iso-SNR contours characteristics analysis for the special bistatic space based radar of operations for area surveillance are depicted in detail. It is shown that the changes in the iso-SNR contours are closely correlative with the special geometry configurations. The conclusions are acquired by comparing with those of monostatic and general bistatic space based radar.

To observe the clinical efficacy of Huangqi Fuzheng Decoction (HQFZD) in treating recurrent genital herpes (RGH) and its influence on related cytokines in peripheral blood.Eighty-four patients with RGH were randomly assigned to 3 groups, the treated group treated with HQFZD (31 cases), the control group A (25 cases) treated with Aciclovir, and the control group B (28 cases) treated with Aciclovir plus interferon. The course of treatment was 3 weeks for all. The relapse rate was estimated at 6 months after treatment, and levels of IL-4, IL-10, IL-12 and IL-18 in all patients were detected before and after treatment using double-sandwich ELISA.All patients were cured after treatment. The relapse rate in the treated group and the control group B was lower than that in the control group A (P0.01) but insignificant difference was shown between the former two groups. Before treatment, patients' serum levels of IL-4 and IL-10 were significantly higher while those of IL-12 and IL-18 were lower than the normal range (P0.01). The abnormal change aforementioned reversed after treatment in the treated group and the control group B (P0.05 or P0.01), showing a superior effect to that in the control group A (P0.01).HQFZD can reduce the relapse rate of RGH without obvious adverse reaction, and it could also enhance the immunity of the patients.

The local electric field enhancements of overlapping Ag triangular nanoplates are investigated using the discrete dipole approximate (DDA) method. The enhancement region of local electric field in the gap could be focused and enlarged by adjusting the thickness and the number of layers of the nanoplates. For the double-layer Ag triangular nanoplates, with the thickness increasing, the electric field enhancements transform from near the corners to the center of the gap gradually and the intensities get stronger. The largest “hot spot volume” appears as the thickness increases to 20 nm. The plasmonic coupling between the two nanoplates leads to the surface charges accumulating on the surfaces adjoining the gap. The variation of the surface charges due to the increase of the thickness should be responsible for this phenomenon. For the multilayer Ag triangular nanoplates, the enhancement region enlarges as the number of layers increases. And the “hot spot volume” could reach about 72% of the total volume of the middle gap when the number of layers is 6. The large volume of the intense electric field enhancements obtained in overlapping Ag triangular nanoplates provide potential for surface-enhanced Raman scattering (SERS) and surface enhancement fluorescence (SEF) applications.

To study a simple and scientific method to produce the animal model of diabetic cardiomyopathy.Injecting the streptozotocin (STZ) liquid at the left iliac region only once in the model group, observing the general condition, the change of eating level, drinking level, urine level and weight, examining the level of creatine kinase ( CK- MB) , lactate dehydrogenase (LDH-1 ) , insulin, blood sugar and urine sugar. Observe the cardiac muscle ultrastructure, the large vessel tunica intima and electrocardiogram.After injecting the STZ 3 weeks, the model rats appear morbid, the value of eating, drinking, urine are increased and weight decreased. The model rat blood sugar, urine sugar, CK and LDH levels are higher than control rat. The model rat insulin level is lower than control group. The model rat cardiac muscle ultrastructure accord with the diabetic cardiomyopathy' s, and the fibrous or atheromatous plaque do not been found at the large vessel tunica intima.The SD model rat appear the diabetic cardiomyopathy condition by injected the STZ (55mg/kg) at the left iliac region only once in 3 weeks. It is a simple and scientific method to produce the animal model of diabetic cardiomyopathy.

For making use of Ginseng resources and finding new anti-tumor drugs, the anti-tumor activity of three kinds of new panaxadiol fatty acid ester derivates: 3beta-acetoxy panaxadiol (I), 3beta-palmitic acid aceloxy panaxadiol (II), 3beta-octadecanoic acid aceloxy panaxadiol (Ill) and panaxaiol were compared through the method of cell stain and counting. Tumor cell was Vero cell line. Positive control was 5-FU. Blank was RPM11640 culture medium. Negative control was RPM11640 culture medium and the solvent for subjected drugs. The result showed that compound I had the strongest anti-tumor activity, second was panaxadiol, II and III had the same and the weakest antitumor activity. Furthermore, the anti-tumor activities of panaxadiol fatty acid ester derivates showed positive correlation with subjects' concentrations, but no relationship with molecular weight of fatty acid.

We investigate realization of the infinite-dimensional 3-algebras in the classical Calogero—Moser model. In terms of the Lax matrix of the Calogero—Moser model and the Nambu 3-brackets in which the variables are the coordinates qi, and canonically conjugate momenta pi and the coupling parameter β are an extra auxiliary phase-space parameter, we present the realization of the Virasoro—Witt, w∞ and SDiff(T2) 3-algebras, respectively.

To observe clinical therapeutic effect of acupuncture on poststroke deglutition disorders.Sixty-eight inpatients of moderate and severe deglutition disorders were treated by the activating brain function to cause resuscitation needling method.Twenty-six cases were cured, 24 were remarkedly effective, 16 were effective, with a total effective rate of 97.06%.This needling method has a markedly therapeutic effect on poststroke moderate and severe deglutition disorders.

Conventional ischaemia-mimetic solutions contain several key components for inducing hypoxia, glucose deficiency, acidosis, lactate accumulation and hyperosmosis. The effect of each component on myocyte contractility during cardiac ischaemia was investigated in this study. A video-based edge-detection system was used to monitor single ventricular myocytes isolated from the rat. The effect of each factor was compared by preparing the following ischaemia-mimetic solutions: solution A, containing all of the above-mentioned factors; and solutions B, C, D, E and F, each with one of the factors excluded. The solutions that contained lactate severely reduced the contractility of the cardiomyocytes, but cell contraction did not differ significantly between the cardiomyocytes in these solutions. The effect of the solution without the acidosis-inducing component was weaker than that of the conventional ischaemia-mimetic solution. The solution lacking lactate produced the least depression of cell contractility. Lactate impaired cardiomyocyte contractility in a concentration-dependent manner. Our observations suggest that lactate is the main contributor to cardiac ischaemic injury and that its effects are attributable to acidosis and are concentration dependent. Imposition of hypoxia, glucose deficiency and hyperosmosis had little impact on the cardiomyocytes.

The author found a novel yellow-white flower color mutation in the male sterile progenies derived from a commercial Brassica.napus hybrid C022, which was produced by a male sterility line 9012A, whose sterility was controlled by interaction between two pairs recessive genes and a pair of epitatic genes. The mutant was named 991S. 991S had three morphologic characters:(1) The color in the middle of every petal was yellow, yet the both sides were white.(2)Every calyx might become striped albino (3) Only male sterile plants in different populations had mutative character. Except flower color, they had similar morphologic characters to the normal male sterile sib-plants. The plants were slender and little with little flowers that had flat petals, bended stigmas, degenerative stamen, and dry anthers. Primary analysis of its origin and inheritance showed that this mutative character was controlled by recessive partial albino gene.

In this paper, a method to determine the severity level of dispute policy based on safe configuration guidance is present. This severity level of dispute policy will provide the network administrator more specific and guided information and help them to choose the debugged routing policy, eliminate policy disputes and solve the route oscillations efficiently. This method first extends Routing Policy Specification Language so as to enable it to describe the relationship between Autonomous Systems, which arises from the commercial contracts. And then, each of Autonomous System utilizes this extended language to describe the relationships between its own and its direct neighbors. When route oscillations occur, the algorithm to determine the dispute routing policies based on dispute cycle avoidance will identify the dispute policy set inducing route oscillations. Finally, according to the relationship of autonomous system and the safe configuration guidance, the severity level of dispute policy will be determined. In addition, a simulation instance is given in order to explain results of this method.

Heart and blood vessels are the pivotal organs that make up of the important system, cardiovascular system, of the body. They are associated functionally and both have the contractility. The pressure of the ventricles can elevate to a high level in a short time when heart contracts, so the cardiomyocytes should contract rapidly and powerfully. The contractile structure and the process of the calcium-modulation are required to meet the demand. The contractility of blood vessels is of slow and per durable characters which are compatible to the related function. This article describes the contractive structure and mechanism, and the related calcium-modulation mechanism cytologically, furthermore, introduces their differences and similarities, respectively.