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103. Corrección en el artículo de Sanz-Sánchez et al., «Tratamiento antiagregante plaquetario único o doble tras implante percutáneo de válvula aórtica. Metanálisis de ensayos clínicos aleatorizados», REC Interv Cardiol. 2021;3:175-181

Author

Sanz Sánchez, Jorge, Pivato, Carlo Andrea, Leone, Pier Pasquale, Regazzoli, Damiano, Chiarito, Mauro, Petriello, Gennaro, Reimers, Bernhard, Condorelli, Gianluigi, Stefanini, Giulio G, Sanz Sánchez, Jorge, Pivato, Carlo Andrea, Leone, Pier Pasquale, Regazzoli, Damiano, Chiarito, Mauro, Petriello, Gennaro, Reimers, Bernhard, Condorelli, Gianluigi, and Stefanini, Giulio G

Published
2022

104. Reversal and removal of oral antithrombotic drugs in patients with active or perceived imminent bleeding.

Author

Cao, Davide, Amabile, Nicolas, Chiarito, Mauro, Lee, Victoria T, Angiolillo, Dominick J, Capodanno, Davide, Bhatt, Deepak L, Mack, Michael J, Storey, Robert F, Schmoeckel, Michael, Gibson, C Michael, Deliargyris, Efthymios N, and Mehran, Roxana

Subjects
ORAL medication, FIBRINOLYTIC agents, HEMORRHAGE, PLATELET aggregation inhibitors, CARDIOVASCULAR diseases
Abstract

Remarkable progress has been made in the pharmacological management of patients with cardiovascular disease, including the frequent use of antithrombotic agents. Nonetheless, bleeding complications remain frequent and potentially life-threatening. Therapeutic interventions relying on prompt antithrombotic drug reversal or removal have been developed to assist clinicians in treating patients with active bleeding or an imminent threat of major bleeding due to urgent surgery or invasive procedures. Early phase studies on these novel strategies have shown promising results using surrogate pharmacodynamic endpoints. However, the benefit of reversing/removing antiplatelet or anticoagulant drugs should always be weighed against the possible prothrombotic effects associated with withdrawal of antithrombotic protection, bleeding, and surgical trauma. Understanding the ischemic-bleeding risk tradeoff of antithrombotic drug reversal and removal strategies in the context of urgent high-risk settings requires dedicated clinical investigations, but challenges in trial design remain, with relevant practical, financial, and ethical implications. [ABSTRACT FROM AUTHOR]

Published
2023
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106. Transcatheter aortic valve replacement in aortic stenosis and cardiac amyloidosis: a systematic review and meta‐analysis

Author

Cannata, Francesco, primary, Chiarito, Mauro, additional, Pinto, Giuseppe, additional, Villaschi, Alessandro, additional, Sanz‐Sánchez, Jorge, additional, Fazzari, Fabio, additional, Regazzoli, Damiano, additional, Mangieri, Antonio, additional, Bragato, Renato M., additional, Colombo, Antonio, additional, Reimers, Bernhard, additional, Condorelli, Gianluigi, additional, and Stefanini, Giulio G., additional

Published
2022
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107. Edge‐to‐edge percutaneous mitral repair for functional ischaemic and non‐ischaemic mitral regurgitation: a systematic review and meta‐analysis

Author

Chiarito, Mauro, primary, Sanz‐Sanchez, Jorge, additional, Pighi, Michele, additional, Cannata, Francesco, additional, Rubbio, Antonio Popolo, additional, Munafò, Andrea, additional, Cao, Davide, additional, Roccasalva, Fausto, additional, Pini, Daniela, additional, Pagnotta, Paolo A., additional, Ettori, Federica, additional, Petronio, Anna Sonia, additional, Tamburino, Corrado, additional, Reimers, Bernhard, additional, Colombo, Antonio, additional, Di Mario, Carlo, additional, Grasso, Carmelo, additional, Mehran, Roxana, additional, Godino, Cosmo, additional, and Stefanini, Giulio G., additional

Published
2022
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108. Percutaneous Tricuspid Valve Repair

Author

Mangieri, Antonio, primary, Sticchi, Alessandro, primary, Gohar, Aisha, primary, Regazzoli, Damiano, primary, Fazzari, Fabio, primary, Pini, Daniela, primary, Pellegrino, Marta, primary, Pagliaro, Beniamino, primary, Loiacono, Ferdinando, primary, Chiarito, Mauro, primary, Reimers, Bernhard, primary, Praz, Fabien, primary, Latib, Azeem, primary, and Colombo, Antonio, primary

Published
2022
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109. Prognostic impact of the updated 2018 HFA‐ESC definition of advanced heart failure: results from the HELP‐HF registry

Author

Pagnesi, Matteo, primary, Lombardi, Carlo Mario, additional, Chiarito, Mauro, additional, Stolfo, Davide, additional, Baldetti, Luca, additional, Loiacono, Ferdinando, additional, Tedino, Chiara, additional, Arrigoni, Luca, additional, Ghiraldin, Daniele, additional, Tomasoni, Daniela, additional, Inciardi, Riccardo Maria, additional, Maccallini, Marta, additional, Villaschi, Alessandro, additional, Gasparini, Gaia, additional, Montella, Marco, additional, Contessi, Stefano, additional, Cocianni, Daniele, additional, Perotto, Maria, additional, Barone, Giuseppe, additional, Merlo, Marco, additional, Cappelletti, Alberto Maria, additional, Sinagra, Gianfranco, additional, Pini, Daniela, additional, and Metra, Marco, additional

Published
2022
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111. Perioperative management of P2Y12 inhibitors in patients undergoing cardiac surgery within 1 year of PCI

Author

Cao, Davide, primary, Swain, Julie A, additional, Sartori, Samantha, additional, Nardin, Matteo, additional, Zhang, Zhongjie, additional, Roumeliotis, Anastasios, additional, Nicolas, Johny, additional, Chiarito, Mauro, additional, Chandiramani, Rishi, additional, Pivato, Carlo A, additional, Spirito, Alessandro, additional, Giustino, Gennaro, additional, Stefanini, Giulio G, additional, Dangas, George D, additional, Baber, Usman, additional, Bhatt, Deepak L, additional, Adams, David H, additional, Sharma, Samin K, additional, Kini, Annapoorna S, additional, and Mehran, Roxana, additional

Published
2022
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112. IMPACT OF CORONARY ARTERY DISEASE ON CLINICAL OUTCOMES AFTER TAVR: INSIGHTS FROM THE BRAVO-3 RANDOMIZED TRIAL

Author

Feldman, Daniel, primary, Cao, Davide, additional, Nicolas, Johny, additional, Hengstenberg, Christian, additional, Zhang, Zhongie, additional, Sartori, Samantha, additional, Beerkens, Frans, additional, Pivato, Carlo Andrea, additional, Chiarito, Mauro, additional, Satish, Mohan, additional, Jones, Davis B., additional, Iyer, Divya, additional, Power, David, additional, Chen, Huazhen, additional, Camaj, Anton, additional, Razuk, Victor, additional, Roumeliotis, Anastasios, additional, Jeger, Raban V., additional, Violini, Roberto, additional, Ferrari, Markus, additional, Mehran, Roxana, additional, and Dangas, George D., additional

Published
2022
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113. PREDICTORS OF ANTIPLATELET CESSATION IN A REAL-WORLD PATIENT POPULATION WITH CORONARY STENTS UNDERGOING NONCARDIAC SURGERY

Author

Koshy, Anoop Ninan, primary, Cao, Davide, additional, Sartori, Samantha, additional, Kini, Annapoorna Subhash, additional, Zhang, Zhongjie, additional, Claessen, Bimmer, additional, Nardin, Matteo, additional, Pivato, Carlo Andrea, additional, Chandiramani, Rishi, additional, Giustino, Gennaro, additional, Chiarito, Mauro, additional, Nicolas, Johny, additional, Sharma, Samin K., additional, and Mehran, Roxana, additional

Published
2022
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114. IMPACT OF CHRONIC THROMBOCYTOPENIA ON CLINICAL OUTCOMES AFTER TAVR: INSIGHTS FROM THE BRAVO-3 RANDOMIZED TRIAL

Author

Feldman, Daniel, primary, Cao, Davide, additional, Razuk, Victor, additional, Nicolas, Johny, additional, Hengstenberg, Christian, additional, Zhang, Zhongie, additional, Sartori, Samantha, additional, Beerkens, Frans, additional, Pivato, Carlo Andrea, additional, Chiarito, Mauro, additional, Jones, Davis B., additional, Satish, Mohan, additional, Roumeliotis, Anastasios, additional, Power, David, additional, Camaj, Anton, additional, Jeger, Raban V., additional, Violini, Roberto, additional, Ferrari, Markus, additional, Mehran, Roxana, additional, and Dangas, George D., additional

Published
2022
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115. Prognostic value of tricuspid regurgitation

Author

Leone, Pier Pasquale, primary, Chiarito, Mauro, primary, Regazzoli, Damiano, primary, Pellegrino, Marta, primary, Monti, Lorenzo, primary, Pagliaro, Beniamino, primary, Loiacono, Ferdinando, primary, Stefanini, Giulio, primary, Pini, Daniela, primary, Reimers, Bernhard, primary, Colombo, Antonio, primary, Latib, Azeem, primary, and Mangieri, Antonio, primary

Published
2022
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116. Correction in article by Sanz-S�nchez et al. �Single or dual antiplatelet therapy after transcatheter aortic valve implantation. A meta-analysis of randomized controlled trials�, REC Interv Cardiol. 2021;3:175-181

Author

Sanz-Sánchez, Jorge, primary, Andrea Pivato, Carlo, additional, Pasquale Leone, Pier, additional, Regazzoli, Damiano, additional, Chiarito, Mauro, additional, Petriello, Gennaro, additional, Reimers, Bernhard, additional, Condorelli, Gianluigi, additional, and G. Stefanini, and Giulio, additional

Published
2022
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117. Correcci�n en el art�culo de Sanz-S�nchez et al., �Tratamiento antiagregante plaquetario �nico o doble tras implante percut�neo de v�lvula a�rtica. Metan�lisis de ensayos cl�nicos aleatorizados�, REC Interv Cardiol. 2021;3:175-181

Author

Sanz-Sánchez, Jorge, primary, Andrea Pivato, Carlo, additional, Pasquale Leone, Pier, additional, Regazzoli, Damiano, additional, Chiarito, Mauro, additional, Petriello, Gennaro, additional, Reimers, Bernhard, additional, Condorelli y, Gianluigi, additional, and G. Stefanini, Giulio, additional

Published
2022
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118. SGLT-2 inhibitors and cardiovascular outcomes in patients with and without a history of heart failure: a systematic review and meta-analysis

Author

Razuk, Victor, primary, Chiarito, Mauro, additional, Cao, Davide, additional, Nicolas, Johny, additional, Pivato, Carlo A, additional, Camaj, Anton, additional, Power, David, additional, Beerkens, Frans, additional, Jones, Davis, additional, Alter, Aviv, additional, Mathew, Alvin, additional, Spirito, Alessandro, additional, Contreras, Johanna P, additional, Dangas, George D, additional, and Mehran, Roxana, additional

Published
2022
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119. Evolution of drug-eluting coronary stents: a back-and-forth journey from the bench to bedside.

Author

Nicolas, Johny, Pivato, Carlo Andrea, Chiarito, Mauro, Beerkens, Frans, Cao, Davide, and Mehran, Roxana

Subjects
SURGICAL stents, DRUG-eluting stents, TRANSLUMINAL angioplasty, CORONARY artery disease, DRUG coatings
Abstract

Coronary stents have revolutionized the treatment of coronary artery disease. Compared with balloon angioplasty, bare-metal stents (BMSs) effectively prevented abrupt vessel closure but were limited by in-stent restenosis (ISR) due to smooth muscle cell proliferation and neointimal hyperplasia. The first-generation drug-eluting stent (DES), with its antiproliferative drug coating, offered substantial advantages over BMSs as it mitigated the risk of ISR. Nonetheless, they had several design limitations that increased the risk of late stent thrombosis. Significant advances in stent design, including thinner struts, enhanced polymers' formulation, and more potent antiproliferative agents, have led to the introduction of new-generation DES with a superior safety profile. Cardiologists have over 20 different DES types to choose from, each with its unique features and characteristics. This review highlights the evolution of stent design and summarizes the clinical data on the different stent types. We conclude by discussing the clinical implications of stent design in high-risk subsets of patients. [ABSTRACT FROM AUTHOR]

Published
2023
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120. Contributors

Author

Adriaenssens, Tom, Agarwal, Shikhar, Alfonso, Fernando, AlMahameed, Amjad T., Anwaruddin, Saif, Aoun, Joe, Baber, Usman, Bandisode, Varsha, Banerjee, Subhash, Bangalore, Sripal, Bavry, Anthony A., Bertog, Stefan, Bhatt, Deepak L., Bittl, John A., Brilakis, Emmanouil S., Byrne, Robert A., Chebl, Alex Bou, Chiarito, Mauro, Colombo, Antonio, Coughlan, J.J., Dangas, George, Esposito, Michele L., Faxon, David P., Goel, Sachin S., Gray, William A., Généreux, Philippe, Hering, Dagmara, Herrmann, Howard C., Iloska, Pamela, Jang, Ik-Kyung, Jneid, Hani, Jumean, Marwan F., Kandzari, David E., Kapadia, Samir R., Kapur, Navin K., Kastrati, Adnan, Kern, Morton J., Kinlay, Scott, Klein, Lloyd W., Kodali, Susheel K., Krishnaswamy, Amar, Latib, Azeem, Leon, Martin B., Margey, Ronan, Mehran, Roxana, Nanjundappa, Aravinda, Ng, Vivian G., Nicholson, William J., O’Neill, Brian, Osborn, John W., O’Neill, William W., Palacios, Igor F., Prieto, Lourdes R., Rajpurohit, Vikram, Raphael, Claire E., Reinartz, Markus, Rhodes, John F., Jr., Sandesara, Pratik, Shammas, Nicolas W., Sharma, Alok, Sievert, Horst, Sievert, Kolja, Sista, Akhilesh K., Stone, Gregg W., Tuzcu, E. Murat, Vedantham, Suresh, White, Christopher J., Williams, David O., Young, James B., and Ziada, Khaled M.

Published
2024
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123. 21 Direct oral anticoagulants vs. vitamin K antagonists in the treatment of left ventricular thrombosis: a systematic review and meta-analysis

Author

Condello, Francesco, primary, Maurina, Matteo, additional, Chiarito, Mauro, additional, Sturla, Matteo, additional, Terzi, Riccardo, additional, Fazzari, Fabio, additional, Sanz-Sanchez, Jorge, additional, Cannata, Francesco, additional, Condorelli, Gianluigi, additional, and Stefanini, Giulio, additional

Published
2021
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124. 464 Implantation of contemporary transcatheter aortic valves in small aortic annuli: the international multicentre TAVI-SMALL 2 registry

Author

Leone, Pier Pasquale, primary, Regazzoli, Damiano, additional, Cannata, Francesco, additional, Pagnesi, Matteo, additional, Chiarito, Mauro, additional, Barbanti, Marco, additional, Teles, Rui, additional, Adamo, Marianna, additional, Miura, Mizuki, additional, Taramasso, Maurizio, additional, Stefanini, Giulio, additional, Mangieri, Antonio, additional, Kargoli, Faraj, additional, Ohno, Yohei, additional, Saia, Francesco, additional, Buono, Andrea, additional, Ielasi, Alfonso, additional, Ribichini, Flavio, additional, Maffeo, Diego, additional, Bedogni, Francesco, additional, Kim, Won-keun, additional, Maisano, Francesco, additional, Curello, Salvatore, additional, Tamburino, Corrado, additional, Van Mieghem, Nicolas, additional, Colombo, Antonio, additional, Reimers, Bernhard, additional, and Latib, Azeem, additional

Published
2021
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125. 480 Catheter pulmonary vein ablation vs. medical therapy or atrioventricular node ablation and resynchronization in patients with atrial fibrillation and heart failure: a systematic review and meta-analysis

Author

Liccardo, Gaetano, primary, Cannata, Francesco, additional, Chiarito, Mauro, additional, Bombace, Sara, additional, Maccallini, Marta, additional, Villaschi, Alessandro, additional, Pinto, Giuseppe, additional, Fazzari, Fabio, additional, Pini, Daniela, additional, Bragato, Renato Maria, additional, Condorelli, Gianluigi, additional, Cappato, Riccardo, additional, and Stefanini, Giulio G, additional

Published
2021
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126. 241 Transcatheter aortic valve replacement in aortic stenosis and cardiac amyloidosis: a systematic review and meta-analysis

Author

Cannata, Francesco, primary, Chiarito, Mauro, additional, Pinto, Giuseppe, additional, Villaschi, Alessandro, additional, Sanz-sanchez, Jorge, additional, Fazzari, Fabio, additional, Regazzoli, Damiano, additional, Mangieri, Antonio, additional, Bragato, Renato M, additional, Colombo, Antonio, additional, Reimers, Bernhard, additional, Condorelli, Gianluigi, additional, and Stefanini, Giulio G, additional

Published
2021
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127. 401 Myocardial viability and ischaemia assessment in chronic coronary total occlusions according to collaterals distribution: a retrospective analysis

Author

Pinto, Giuseppe, primary, Chiarito, Mauro, additional, Liccardo, Gaetano, additional, Baggio, Sara, additional, Bacci, Elodi, additional, Gasparini, Gabriele, additional, Francone, Marco, additional, Stefanini, Giulio, additional, Condorelli, Gianluigi, additional, and Monti, Lorenzo, additional

Published
2021
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129. Abstract 12919: Impact of Small Valve Size After Transcatheter Aortic Valve Implantation on 1-year Outcomes in Women: Results From the WIN-TAVI Registry

Author

Pivato, Carlo Andrea, primary, Cao, Davide, additional, Sartori, Samantha, additional, Snyder, Clayton, additional, Nicolas, Johny, additional, Chiarito, Mauro, additional, Tavennier, Annerieke, additional, Nardin, Matteo, additional, Sharma, Samin K, additional, Mehilli, Julinda, additional, Petronio, Anna S, additional, Morice, Marie c, additional, Chieffo, Alaide, additional, Dangas, George, additional, and Mehran, Roxana, additional

Published
2021
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130. Abstract 13145: Impact of Chronic Obstructive Pulmonary Disease and Smoking on Clinical Outcomes After Percutaneous Coronary Intervention

Author

Nardin, Matteo, primary, Cao, Davide, additional, Chiarito, Mauro, additional, Nicolas, Johny, additional, Pivato, Carlo Andrea, additional, Tavenier, Annerieke, additional, Sartori, Samantha, additional, Zhang, Zhongjie, additional, Qiu, Hanbo, additional, Krishnan, Prakash, additional, Barman, Nitin, additional, Sweeny, Joseph, additional, Dangas, George, additional, Mehran, Roxana, additional, Sharma, Samin K, additional, and Kini, Annapoorna, additional

Published
2021
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131. Abstract 13808: Impact of Complex Percutaneous Coronary Intervention Features Among Patients With or Without Chronic Kidney Disease

Author

Nicolas, Johny, primary, Cao, Davide, additional, Zhang, Zhongjie, additional, Sartori, Samantha, additional, Pivato, Carlo Andrea, additional, Tavenier, Annerieke, additional, Beerkens, Frans, additional, Camaj, Anton, additional, Razuk, Victor, additional, Jones, Davis, additional, Chiarito, Mauro, additional, Baber, Usman, additional, Sweeny, Joseph, additional, Krishnan, Prakash, additional, Sharma, Samin K, additional, Kini, Annapoorna, additional, Dangas, George, additional, and Mehran, Roxana, additional

Published
2021
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132. Tratamiento antiagregante plaquetario �nico o doble tras implante percut�neo de v�lvula a�rtica. Metan�lisis de ensayos cl�nicos aleatorizados

Author

Sanz-Sánchez, Jorge, primary, Andrea Pivato, Carlo, additional, Pasquale Leone, Pier, additional, Regazzoli, Damiano, additional, Chiarito, Mauro, additional, Petriello, Gennaro, additional, Reimers, Bernhard, additional, Condorelli y, Gianluigi, additional, and G. Stefanini, Giulio, additional

Published
2021
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134. TCT-228 Prasugrel or Clopidogrel in Patients With Acute Coronary Syndromes With Multivessel Disease: Results From the PROMETHEUS Study

Author

Chiarito, Mauro, primary, Pivato, Carlo Andrea, additional, Cao, Davide, additional, Zhang, Zhongjie, additional, Sartori, Samantha, additional, Nicolas, Johny, additional, Nardin, Matteo, additional, Kapadia, Samir, additional, Weiss, Sandra, additional, Rao, Sunil, additional, Henry, Timothy, additional, Effron, Mark, additional, Weintraub, William, additional, Pocock, Stuart, additional, Dangas, George, additional, Kini, Annapoorna, additional, and Mehran, Roxana, additional

Published
2021
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135. TCT-346 The Mega COMBO Collaboration: An Individual Patient Data Pooled Analysis of Patients Undergoing PCI With COMBO Stent

Author

Nardin, Matteo, primary, Pivato, Carlo Andrea, additional, Cao, Davide, additional, Zhang, Zhongjie, additional, Sartori, Samantha, additional, Nicolas, Johny, additional, Chiarito, Mauro, additional, Qiu, Hanbo, additional, Abizaid, Alexandre, additional, Christiansen, Evald, additional, Colombo, Antonio, additional, de Winter, Robbert, additional, Haude, Michael, additional, Jakobsen, Lars, additional, Jensen, Lisette Okkels, additional, Landmesser, Ulf, additional, Saito, Shigeru, additional, Suryapranata, Harry, additional, De Luca, Giuseppe, additional, Dangas, George, additional, and Mehran, Roxana, additional

Published
2021
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136. Polymer-free biolimus-A9-eluting stent performance according to renal impairment

Author

Chiarito, Mauro, primary, Sturla, Matteo, additional, Briguori, Carlo, additional, Mancone, Massimo, additional, Tamburino, Corrado, additional, Fabbiocchi, Franco, additional, Trabattoni, Daniela, additional, Tomai, Fabrizio, additional, Paggi, Anita, additional, Gioffrè, Gaetano, additional, Sclafani, Rocco, additional, Giordano, Arturo, additional, Stefanini, Giulio G., additional, and Sardella, Gennaro, additional

Published
2021
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137. Efficacy and safety of P2Y12inhibitor monotherapy after complex PCI: a collaborative systematic review and meta-analysis

Author

Nicolas, Johny, Dangas, George, Chiarito, Mauro, Pivato, Carlo A, Spirito, Alessandro, Cao, Davide, Giustino, Gennaro, Beerkens, Frans, Camaj, Anton, Vogel, Birgit, Sartori, Samantha, Yamamoto, Ko, Kimura, Takeshi, Kim, Byeong-Keuk, Baber, Usman, and Mehran, Roxana

Abstract

Graphical AbstractForest plot showing the relative hazard of bleeding and ischaemic complications among patients undergoing complex and non-complex percutaneous coronary intervention and enroled in five major randomized trials.

Published
2023
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139. Impact of target vessel choice on outcomes following percutaneous coronary intervention in patients with a prior coronary artery bypass graft

Author

Beerkens, Frans J., primary, Singh, Ranbir, additional, Cao, Davide, additional, Claessen, Bimmer E., additional, Nicolas, Johny, additional, Sartori, Samantha, additional, Snyder, Clayton, additional, Camaj, Anton, additional, Giustino, Gennaro, additional, Power, David, additional, Razuk, Victor, additional, Jones, Davis, additional, Tavenier, Anne H., additional, Pivato, Carlo Andrea, additional, Nardin, Matteo, additional, Chiarito, Mauro, additional, Krishnan, Prakash, additional, Barman, Nitin, additional, Baber, Usman, additional, Sweeny, Joseph, additional, Dangas, George, additional, Sharma, Samin K., additional, Mehran, Roxana, additional, and Kini, Annapoorna, additional

Published
2021
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140. Sex-Related Differences in the Prevalence and Prognostic Value of the Academic Research Consortium for High Bleeding Risk Criteria

Author

Nardin, Matteo, primary, Cao, Davide, additional, Mehran, Roxana, additional, Chandiramani, Rishi, additional, Chiarito, Mauro, additional, Sartori, Samantha, additional, Qiu, Hanbo, additional, Zhang, Zhongjie, additional, Golani, Ekta, additional, Nicolas, Johny, additional, Baber, Usman, additional, Dangas, George, additional, De Luca, Giuseppe, additional, Stefanini, Giulio G., additional, Sweeny, Joseph, additional, Sharma, Samin K., additional, and Kini, Annapoorna, additional

Published
2021
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141. Guided and unguided de-escalation from potent P2Y12 inhibitors among patients with acute coronary syndrome: a meta-analysis

Author

Tavenier, Anne H, primary, Mehran, Roxana, additional, Chiarito, Mauro, additional, Cao, Davide, additional, Pivato, Carlo A, additional, Nicolas, Johny, additional, Beerkens, Frans, additional, Nardin, Matteo, additional, Sartori, Samantha, additional, Baber, Usman, additional, Angiolillo, Dominick J, additional, Capodanno, Davide, additional, Valgimigli, Marco, additional, Hermanides, Renicus S, additional, van ‘t Hof, Arnoud W J, additional, ten Berg, Jur M, additional, Chang, Kiyuk, additional, Kini, Annapoorna S, additional, Sharma, Samin K, additional, and Dangas, George, additional

Published
2021
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142. Types of myocardial injury and mid-term outcomes in patients with COVID-19

Author

Kini, Annapoorna, primary, Cao, Davide, additional, Nardin, Matteo, additional, Sartori, Samantha, additional, Zhang, Zhongjie, additional, Pivato, Carlo Andrea, additional, Chiarito, Mauro, additional, Nicolas, Johny, additional, Vengrenyuk, Yuliya, additional, Krishnamoorthy, Parasuram, additional, Sharma, Samin K, additional, Dangas, George, additional, Fuster, Valentin, additional, and Mehran, Roxana, additional

Published
2021
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143. Perioperative risk and antiplatelet management in patients undergoing non-cardiac surgery within 1 year of PCI

Author

Cao, Davide, primary, Levin, Matthew A., additional, Sartori, Samantha, additional, Claessen, Bimmer, additional, Roumeliotis, Anastasios, additional, Zhang, Zhongjie, additional, Nicolas, Johny, additional, Chandiramani, Rishi, additional, Bedekar, Rashi, additional, Waseem, Zaha, additional, Goel, Ridhima, additional, Chiarito, Mauro, additional, Lupo, Bonnie, additional, Jhang, Jeffrey, additional, Dangas, George D., additional, Baber, Usman, additional, Bhatt, Deepak L., additional, Sharma, Samin K., additional, Kini, Annapoorna S., additional, and Mehran, Roxana, additional

Published
2021
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144. Performance of the academic research consortium high-bleeding risk criteria in patients undergoing PCI for acute myocardial infarction

Author

Nicolas, Johny, primary, Beerkens, Frans, additional, Cao, Davide, additional, Sartori, Samantha, additional, Pivato, Carlo Andrea, additional, Qiu, Hanbo, additional, Giustino, Gennaro, additional, Chiarito, Mauro, additional, Claessen, Bimmer E., additional, Zhang, Zhongjie, additional, Nardin, Matteo, additional, Razuk, Victor, additional, Jones, Davis, additional, Camaj, Anton, additional, Power, David, additional, Banashefski, Bryana, additional, Sweeny, Joseph, additional, Baber, Usman, additional, Dangas, George, additional, Sharma, Samin K., additional, Kini, Annapoorna, additional, and Mehran, Roxana, additional

Published
2021
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145. Predictors and Clinical Impact of Prosthesis-Patient Mismatch After Self-Expandable TAVI in Small Annuli - From TAVI FROM TAVI-SMALL Registry

Author

Leone, Pier Pasquale, primary, Regazzoli, Damiano, additional, Pagnesi, Matteo, additional, Sanz-Sanchez, Jorge, additional, Chiarito, Mauro, additional, Cannata, Francesco, additional, Van Mieghem, Nicolas M., additional, Barbanti, Marco, additional, Tamburino, Corrado, additional, Teles, Rui, additional, Adamo, Marianna, additional, Miura, Mizuki, additional, Maisano, Francesco, additional, Kim, Won-Keun, additional, Bedogni, Francesco, additional, Stefanini, Giulio, additional, Mangieri, Antonio, additional, Giannini, Francesco, additional, Colombo, Antonio, additional, Reimers, Bernhard, additional, and Latib, Azeem, additional

Published
2021
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146. Clinical Challenges in an Unusual Setting: ST-Elevation in a Patient Suffering From Graft Versus Host Disease, Between Thrombosis and Coronary Spasm

Author

Liccardo, Gaetano, primary, Corrada, Elena, additional, Bertoldi, Letizia, additional, Briani, Martina, additional, Sanz-Sanchez, Jorge, additional, Chiarito, Mauro, additional, Mariotti, Jacopo, additional, de Philippis, Chiara, additional, Santoro, Armando, additional, Reimers, Bernhard, additional, and Regazzoli, Damiano, additional

Published
2021
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147. Lopinavir/Ritonavir and Darunavir/Cobicistat in Hospitalized COVID-19 Patients: Findings From the Multicenter Italian CORIST Study

Author

Di Castelnuovo, A, Costanzo, S, Antinori, A, Berselli, N, Blandi, L, Bonaccio, M, Bruno, R, Cauda, R, Gialluisi, A, Guaraldi, G, Menicanti, L, Mennuni, M, My, I, Parruti, A, Patti, G, Perlini, S, Santilli, F, Signorelli, C, Stefanini, G, Vergori, A, Ageno, W, Aiello, L, Agostoni, P, Al Moghazi, S, Arboretti, R, Aucella, F, Barbieri, G, Barchitta, M, Bartoloni, A, Bologna, C, Bonfanti, P, Caiano, L, Carrozzi, L, Cascio, A, Castiglione, G, Chiarito, M, Ciccullo, A, Cingolani, A, Cipollone, F, Colomba, C, Colombo, C, Crosta, F, Dalena, G, Dal Pra, C, Danzi, G, D'Ardes, D, de Gaetano Donati, K, Di Gennaro, F, Di Tano, G, D'Offizi, G, Filippini, T, Maria Fusco, F, Gaudiosi, C, Gentile, I, Gini, G, Grandone, E, Guarnieri, G, Lamanna, G, Larizza, G, Leone, A, Lio, V, Losito, A, Maccagni, G, Maitan, S, Mancarella, S, Manuele, R, Mapelli, M, Maragna, R, Marra, L, Maresca, G, Marotta, C, Mastroianni, F, Mazzitelli, M, Mengozzi, A, Menichetti, F, Milic, J, Minutolo, F, Molena, B, Mussinelli, R, Mussini, C, Musso, M, Odone, A, Olivieri, M, Pasi, E, Perroni, A, Petri, F, Pinchera, B, Pivato, C, Poletti, V, Ravaglia, C, Rossato, M, Rossi, M, Sabena, A, Salinaro, F, Sangiovanni, V, Sanrocco, C, Scorzolini, L, Sgariglia, R, Simeone, P, Spinicci, M, Trecarichi, E, Veronesi, G, Vettor, R, Vianello, A, Vinceti, M, Visconti, E, Vocciante, L, De Caterina, R, Iacoviello, L, Di Castelnuovo, Augusto, Costanzo, Simona, Antinori, Andrea, Berselli, Nausicaa, Blandi, Lorenzo, Bonaccio, Marialaura, Bruno, Raffaele, Cauda, Roberto, Gialluisi, Alessandro, Guaraldi, Giovanni, Menicanti, Lorenzo, Mennuni, Marco, My, Ilaria, Parruti, Agostino, Patti, Giuseppe, Perlini, Stefano, Santilli, Francesca, Signorelli, Carlo, Stefanini, Giulio G, Vergori, Alessandra, Ageno, Walter, Aiello, Luca, Agostoni, Piergiuseppe, Al Moghazi, Samir, Arboretti, Rosa, Aucella, Filippo, Barbieri, Greta, Barchitta, Martina, Bartoloni, Alessandro, Bologna, Carolina, Bonfanti, Paolo, Caiano, Lucia, Carrozzi, Laura, Cascio, Antonio, Castiglione, Giacomo, Chiarito, Mauro, Ciccullo, Arturo, Cingolani, Antonella, Cipollone, Francesco, Colomba, Claudia, Colombo, Crizia, Crosta, Francesco, Dalena, Giovanni, Dal Pra, Chiara, Danzi, Gian Battista, D'Ardes, Damiano, de Gaetano Donati, Katleen, Di Gennaro, Francesco, Di Tano, Giuseppe, D'Offizi, Gianpiero, Filippini, Tommaso, Maria Fusco, Francesco, Gaudiosi, Carlo, Gentile, Ivan, Gini, Giancarlo, Grandone, Elvira, Guarnieri, Gabriella, Lamanna, Gennaro L F, Larizza, Giovanni, Leone, Armando, Lio, Veronica, Losito, Angela Raffaella, Maccagni, Gloria, Maitan, Stefano, Mancarella, Sandro, Manuele, Rosa, Mapelli, Massimo, Maragna, Riccardo, Marra, Lorenzo, Maresca, Giulio, Marotta, Claudia, Mastroianni, Franco, Mazzitelli, Maria, Mengozzi, Alessandro, Menichetti, Francesco, Milic, Jovana, Minutolo, Filippo, Molena, Beatrice, Mussini, Cristina, Musso, Maria, Odone, Anna, Olivieri, Marco, Pasi, Emanuela, Perroni, Annalisa, Petri, Francesco, Pinchera, Biagio, Pivato, Carlo A, Poletti, Venerino, Ravaglia, Claudia, Rossato, Marco, Rossi, Marianna, Sabena, Anna, Salinaro, Francesco, Sangiovanni, Vincenzo, Sanrocco, Carlo, Scorzolini, Laura, Sgariglia, Raffaella, Simeone, Paola Giustina, Spinicci, Michele, Trecarichi, Enrico Maria, Veronesi, Giovanni, Vettor, Roberto, Vianello, Andrea, Vinceti, Marco, Visconti, Elena, Vocciante, Laura, De Caterina, Raffaele, Iacoviello, Licia, Di Castelnuovo, A, Costanzo, S, Antinori, A, Berselli, N, Blandi, L, Bonaccio, M, Bruno, R, Cauda, R, Gialluisi, A, Guaraldi, G, Menicanti, L, Mennuni, M, My, I, Parruti, A, Patti, G, Perlini, S, Santilli, F, Signorelli, C, Stefanini, G, Vergori, A, Ageno, W, Aiello, L, Agostoni, P, Al Moghazi, S, Arboretti, R, Aucella, F, Barbieri, G, Barchitta, M, Bartoloni, A, Bologna, C, Bonfanti, P, Caiano, L, Carrozzi, L, Cascio, A, Castiglione, G, Chiarito, M, Ciccullo, A, Cingolani, A, Cipollone, F, Colomba, C, Colombo, C, Crosta, F, Dalena, G, Dal Pra, C, Danzi, G, D'Ardes, D, de Gaetano Donati, K, Di Gennaro, F, Di Tano, G, D'Offizi, G, Filippini, T, Maria Fusco, F, Gaudiosi, C, Gentile, I, Gini, G, Grandone, E, Guarnieri, G, Lamanna, G, Larizza, G, Leone, A, Lio, V, Losito, A, Maccagni, G, Maitan, S, Mancarella, S, Manuele, R, Mapelli, M, Maragna, R, Marra, L, Maresca, G, Marotta, C, Mastroianni, F, Mazzitelli, M, Mengozzi, A, Menichetti, F, Milic, J, Minutolo, F, Molena, B, Mussinelli, R, Mussini, C, Musso, M, Odone, A, Olivieri, M, Pasi, E, Perroni, A, Petri, F, Pinchera, B, Pivato, C, Poletti, V, Ravaglia, C, Rossato, M, Rossi, M, Sabena, A, Salinaro, F, Sangiovanni, V, Sanrocco, C, Scorzolini, L, Sgariglia, R, Simeone, P, Spinicci, M, Trecarichi, E, Veronesi, G, Vettor, R, Vianello, A, Vinceti, M, Visconti, E, Vocciante, L, De Caterina, R, Iacoviello, L, Di Castelnuovo, Augusto, Costanzo, Simona, Antinori, Andrea, Berselli, Nausicaa, Blandi, Lorenzo, Bonaccio, Marialaura, Bruno, Raffaele, Cauda, Roberto, Gialluisi, Alessandro, Guaraldi, Giovanni, Menicanti, Lorenzo, Mennuni, Marco, My, Ilaria, Parruti, Agostino, Patti, Giuseppe, Perlini, Stefano, Santilli, Francesca, Signorelli, Carlo, Stefanini, Giulio G, Vergori, Alessandra, Ageno, Walter, Aiello, Luca, Agostoni, Piergiuseppe, Al Moghazi, Samir, Arboretti, Rosa, Aucella, Filippo, Barbieri, Greta, Barchitta, Martina, Bartoloni, Alessandro, Bologna, Carolina, Bonfanti, Paolo, Caiano, Lucia, Carrozzi, Laura, Cascio, Antonio, Castiglione, Giacomo, Chiarito, Mauro, Ciccullo, Arturo, Cingolani, Antonella, Cipollone, Francesco, Colomba, Claudia, Colombo, Crizia, Crosta, Francesco, Dalena, Giovanni, Dal Pra, Chiara, Danzi, Gian Battista, D'Ardes, Damiano, de Gaetano Donati, Katleen, Di Gennaro, Francesco, Di Tano, Giuseppe, D'Offizi, Gianpiero, Filippini, Tommaso, Maria Fusco, Francesco, Gaudiosi, Carlo, Gentile, Ivan, Gini, Giancarlo, Grandone, Elvira, Guarnieri, Gabriella, Lamanna, Gennaro L F, Larizza, Giovanni, Leone, Armando, Lio, Veronica, Losito, Angela Raffaella, Maccagni, Gloria, Maitan, Stefano, Mancarella, Sandro, Manuele, Rosa, Mapelli, Massimo, Maragna, Riccardo, Marra, Lorenzo, Maresca, Giulio, Marotta, Claudia, Mastroianni, Franco, Mazzitelli, Maria, Mengozzi, Alessandro, Menichetti, Francesco, Milic, Jovana, Minutolo, Filippo, Molena, Beatrice, Mussini, Cristina, Musso, Maria, Odone, Anna, Olivieri, Marco, Pasi, Emanuela, Perroni, Annalisa, Petri, Francesco, Pinchera, Biagio, Pivato, Carlo A, Poletti, Venerino, Ravaglia, Claudia, Rossato, Marco, Rossi, Marianna, Sabena, Anna, Salinaro, Francesco, Sangiovanni, Vincenzo, Sanrocco, Carlo, Scorzolini, Laura, Sgariglia, Raffaella, Simeone, Paola Giustina, Spinicci, Michele, Trecarichi, Enrico Maria, Veronesi, Giovanni, Vettor, Roberto, Vianello, Andrea, Vinceti, Marco, Visconti, Elena, Vocciante, Laura, De Caterina, Raffaele, and Iacoviello, Licia

Abstract

Background: Protease inhibitors have been considered as possible therapeutic agents for COVID-19 patients. Objectives: To describe the association between lopinavir/ritonavir (LPV/r) or darunavir/cobicistat (DRV/c) use and in-hospital mortality in COVID-19 patients. Study Design: Multicenter observational study of COVID-19 patients admitted in 33 Italian hospitals. Medications, preexisting conditions, clinical measures, and outcomes were extracted from medical records. Patients were retrospectively divided in three groups, according to use of LPV/r, DRV/c or none of them. Primary outcome in a time-to event analysis was death. We used Cox proportional-hazards models with inverse probability of treatment weighting by multinomial propensity scores. Results: Out of 3,451 patients, 33.3% LPV/r and 13.9% received DRV/c. Patients receiving LPV/r or DRV/c were more likely younger, men, had higher C-reactive protein levels while less likely had hypertension, cardiovascular, pulmonary or kidney disease. After adjustment for propensity scores, LPV/r use was not associated with mortality (HR = 0.94, 95% CI 0.78 to 1.13), whereas treatment with DRV/c was associated with a higher death risk (HR = 1.89, 1.53 to 2.34, E-value = 2.43). This increased risk was more marked in women, in elderly, in patients with higher severity of COVID-19 and in patients receiving other COVID-19 drugs. Conclusions: In a large cohort of Italian patients hospitalized for COVID-19 in a real-life setting, the use of LPV/r treatment did not change death rate, while DRV/c was associated with increased mortality. Within the limits of an observational study, these data do not support the use of LPV/r or DRV/c in COVID-19 patients.

Published
2021

148. Tratamiento antiagregante plaquetario único o doble tras implante percutáneo de válvula aórtica.: Metanálisis de ensayos clínicos aleatorizados

Author

Pivato, Carlo Andrea, Leone, Pier Pasquale, Regazzoli, Damiano, Chiarito, Mauro, Petriello, Gennaro, Reimers, Bernhard, Condorelli, Gianluigi, Stefanini, Giulio G, Sanz Sánchez, Jorge, Pivato, Carlo Andrea, Leone, Pier Pasquale, Regazzoli, Damiano, Chiarito, Mauro, Petriello, Gennaro, Reimers, Bernhard, Condorelli, Gianluigi, Stefanini, Giulio G, and Sanz Sánchez, Jorge

Abstract

Introduction and objectives: Current expert consensus guidelines recommend dual antiplatelet therapy (DAPT) with aspirin and clopidogrel as antithrombotic strategy after transcatheter aortic valve implantation (TAVI) in patients without an indication for long-term oral anticoagulation. However, these recommendations have not been developed based on the results of large randomized clinical trials. The objective of this study is to compare single antiplatelet therapy (SAPT) to DAPT in patients without an indication for long-term anticoagulation after TAVI. Methods: The PubMed, Embase, and the main international conference proceedings were reviewed in the search for randomized controlled trials comparing SAPT to DAPT after TAVI. Data were pooled using a meta-analysis and a random effects model. The primary endpoint was life-threatening or major bleeding. Results: Four trials enrolling 1086 patients were included. Compared to patients treated with DAPT, those treated with SAPT showed a lower risk of life-threatening or major bleeding (OR, 0.44; 95%CI, 0.27-0.70), and any bleeding (OR, 0.51; 95%CI, 0.36-0.71). No differences were observed between patients treated with SAPT compared to those treated with DAPT regarding all-cause mortality (OR, 1.01; 95%CI, 0.61-1.68), myocardial infarction (OR, 0.50; 95%CI 0.17-1.41), and stroke (OR, 0.98; 95%CI, 0.54-1.77). Conclusions: In patients without an indication for long-term anticoagulation undergoing TAVI, single antiplatelet therapy with aspirin compared to DAPT is associated with a lower risk of life-threatening or major bleeding and a comparable risk of all-cause mortality, myocardial infarction, and stroke., Introducción y objetivos: Las guías de práctica clínica actuales recomiendan el tratamiento antiagregante plaquetario doble con ácido acetilsalicílico y clopidogrel como estrategia antitrombótica tras el implante percutáneo de válvula aórtica (TAVI) en pacientes sin indicación de anticoagulación oral a largo plazo. Sin embargo, estas recomendaciones no se han desarrollado de acuerdo con los resultados de grandes ensayos aleatorizados. Por ello, el objetivo de esta investigación es comparar la terapia antiplaquetaria en monoterapia con el tratamiento antiagregante doble en pacientes sin indicación de anticoagulación a largo plazo después de un TAVI. Métodos: Se realizaron búsquedas en PubMed, Embase y los principales congresos internacionales para encontrar ensayos clínicos aleatorizados que compararan el tratamiento antiagregante único con el tratamiento antiplaquetario doble después de un TAVI. Los datos se agruparon en un metanálisis mediante un modelo de efectos aleatorios. El objetivo principal del estudio fue la hemorragia grave o potencialmente mortal. Resultados: Se incluyeron cuatro ensayos que en total incluyeron a 1.086 pacientes. Los pacientes bajo tratamiento antiagregante en monoterapia, en comparación con aquellos con tratamiento antiagregante plaquetario doble, tuvieron menor riesgo de hemorragia grave o potencialmente mortal (odds ratio [OR] = 0,44; intervalo de confianza del 95% [IC95%], 0,27-0,70) y de cualquier sangrado (OR = 0,51; IC95%, 0,36-0,71). No se observaron diferencias entre los pacientes tratados con monoterapia y los tratados tratamiento antiagregante plaquetario doble en cuanto a muerte por cualquier causa (OR = 1,01; IC95%, 0,61-1,68), infarto de miocardio (OR = 0,50; IC95%: 0,17-1,41) y accidente cerebrovascular (OR = 0,98; IC95%, 0,54-1,77). Conclusiones: En los pacientes sin indicación de anticoagulación a largo plazo sometidos a TAVI, la monoterapia con ácido acetilsalicílico en comparación el tratamiento antiagregante doble se a

Published
2021

149. Impact of anemia on short-term outcomes after TAVR: A subgroup analysis from the BRAVO-3 randomized trial

Author

Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Circulatory Health, Razuk, Victor, Camaj, Anton, Cao, Davide, Nicolas, Johny, Hengstenberg, Christian, Sartori, Samantha, Zhang, Zhongjie, Power, David, Beerkens, Frans, Chiarito, Mauro, Meneveau, Nicolas, Tron, Christophe, Dumonteil, Nicolas, Widder, Julian D., Ferrari, Markus, Violini, Roberto, Stella, Pieter R., Jeger, Raban, Anthopoulos, Prodromos, Mehran, Roxana, Dangas, George D., Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Circulatory Health, Razuk, Victor, Camaj, Anton, Cao, Davide, Nicolas, Johny, Hengstenberg, Christian, Sartori, Samantha, Zhang, Zhongjie, Power, David, Beerkens, Frans, Chiarito, Mauro, Meneveau, Nicolas, Tron, Christophe, Dumonteil, Nicolas, Widder, Julian D., Ferrari, Markus, Violini, Roberto, Stella, Pieter R., Jeger, Raban, Anthopoulos, Prodromos, Mehran, Roxana, and Dangas, George D.

Published
2021

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