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Objective: To compare the orthopedic function and clinical efficacy between the orthopedic surgery guided by the Stealth Station 8 Navigation System and the Tinavi robot-assisted orthopedic surgery for the treatment of congenital scoliosis. Methods: A retrospective analysis was performed on the patients who underwent surgical treatment for congenital scoliosis between May 2021 and October 2021. Patients were divided into the navigation group or the robotic group according to the adjunct system used. Postoperative computed tomography (CT) and digital radiography (DR) scans were conducted to assess the orthopedic outcomes. Specifically, the pedicle screw placement accuracy was measured, and the accuracy rate was calculated based on the parameters of the Scoliosis Research Society (SRS), sagittal vertical axis (SVA), distance between the C7 plumb line and the central sacral vertical line (C7PL-CSVL), lumbar lordosis (LL), and spine correction rate. Clinical data of both groups were recorded. Results: A total of 60 patients, including 20 cases in the navigation group and 40 cases in the Tinavi group, were selected for this study. All patients were followed up for a mean of 12.1 months. We found that the spine correction rate, C7PL-CSVL, and SVA were better in the navigation group than in the robot group, while there was no significant difference in the pedicle screw placement accuracy between these two groups (P=0.806). However, the rate of small joint protrusion was significantly higher in the navigation group (P=0.000), and the screws were also closer to the anterior cortex in the navigation group (P=0.020). In contrast, the number of scans and intraoperative fluoroscopic dose were higher in the robot group than in the navigation group. The rest of the data were not significantly different between these two groups. Conclusion: O-arm combined with CT 3D real-time navigation system not only has a better orthopedic effect than Tinavi orthopedic robot which also uses optical tracking system in the treatment of adolescent congenital scoliosis, but also exhibits a satisfactory clinical effect. Therefore, although it has several drawbacks, the navigation system is still a good clinical treatment option for scoliosis.

A strategy for the efficient water facilitated photolysis of perfluoroalkyl iodide has been established for the synthesis of various perfluoroalkylated products.

Hepatoblastomas (HBs) are malignant liver tumors that most commonly develop in pediatric patients. Microvascular invasion may be a prognosis factor for patients with HBs. This study aimed to construct a model to predict the survival outcome in HBs.We retrospectively analyzed the clinical data of 311 patients with HBs who underwent surgical resection at our institution between June 2014 and August 2021. First, patients were divided into two groups: those who had pathologic microvascular invasion (n = 146) and those who did not (n = 165). Propensity score-matched (PSM) analysis was carried out between the two groups. The preoperative parameters and overall survival (OS) rate were compared between the two groups. Second, all 311 patients were randomly divided into the training and validation cohort in a ratio of 4:1. A nomogram was created in the training cohort to visualize the prediction of OS. Moreover, the validation cohort was used for validation.Multivariate analysis suggested that age, histology type, microvascular invasion, multifocality, distant metastasis, and macrovascular involvement are independent prognostic factors for HBs. The nomogram showed good predictive ability in the training and validation cohorts with a C-index of 0.878 (95% CI, 0.831-0.925) and 0.847 (95% CI, 0.757-0.937), respectively. The calibration curve indicated good agreement between the prediction and observation for one-, two-, and three-year OS probabilities.By combining preoperative imaging results and other clinical data, we established a nomogram to predict OS probability for patients with HB, which could be a potential tool to guide personalized treatment.

Cascade radical cyclization of N-arylacrylamides is an attractive method to prepare 3,3-disubstituted oxindoles. As the reported methods often require additives and/or photocatalysts, we herein report an additive- and photocatalyst-free deaminative strategy for their synthesis under mild conditions, enabled by photoactivation of an electron donor-acceptor (EDA) complex. DFT studies indicated that the involvement of an explicit xylene solvent molecule can greatly enhance the photoactivity of the EDA complex between N-arylacrylamides and Katritzky salts.