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1,502 results on '"Central nervous system cysts"'

101. All India Institute of Medical Sciences (AIIMS) Reports Findings in Arachnoid Cysts (Multiple spinal extradural arachnoid cysts presenting as compressive myelopathy in a teenager: case report and literature review with special emphasis on...).

Subjects: ARACHNOID cysts, NEUROLOGICAL disorders, SPINAL cord diseases, SPINE abnormalities, CENTRAL nervous system diseases
Abstract: A report from the All India Institute of Medical Sciences (AIIMS) discusses the rare occurrence of multiple synchronous spinal extradural arachnoid cysts (SEDACs) in children, which can lead to cord compression and disability. The researchers conducted a literature review of similar cases and analyzed the pattern of presentation, management, and outcome. They found that complete or near-complete recovery was seen in the majority of cases, but postoperative spine deformity was reported in some children. The study emphasizes the importance of finding dural defects in all cysts and recommends total cyst wall excision with closure of all dural defects as the gold standard treatment. Long-term follow-up for postoperative spine deformity is necessary. [Extracted from the article]
Published: 2023

102. Researcher at Federal University Minas Gerais (UFMG) Describes Research in Arachnoid Cysts (Compressive Myelopathy Caused by Arachnoid Cyst and Extramedullary Hematopoietic Tissue in a Patient with Thalassemia Major).

Subjects: EXTRAMEDULLARY diseases, ARACHNOID cysts, BETA-Thalassemia, RETENTION of urine, NEUROLOGICAL disorders, GENETIC disorders, RESEARCH personnel, INTRAMEDULLARY fracture fixation
Abstract: A recent study conducted at Federal University Minas Gerais (UFMG) focused on arachnoid cysts, which are rare cysts that can cause spinal cord compression. The study described the case of a 31-year-old male with thalassemia major, a genetic blood disorder, who presented with progressive paralysis and urinary retention due to compression from extramedullary hematopoietic tissue and a thoracic arachnoid cyst. The patient underwent radiotherapy and surgery to treat the condition, and experienced improvements in motor function and sphincter control postoperatively. The study concluded that surgery and/or radiotherapy can be effective treatments for medullary compression caused by extramedullary epidural hematopoiesis in thalassemic patients. [Extracted from the article]
Published: 2023

103. Sabzevar University of Medical Sciences Researchers Add New Data to Research in Arachnoid Cysts (An arachnoid cyst rupture complicated with subdural hygroma in a middle-aged woman: a case report and review of the literature).

Abstract: A recent report from Sabzevar University of Medical Sciences discusses the case of a middle-aged woman who experienced a rupture of an arachnoid cyst, which was complicated by subdural hygroma. Arachnoid cysts are rare and usually asymptomatic, but in this case, the woman developed localized headaches after a minor head trauma. Initially, conservative management was pursued, but due to worsening symptoms, surgery was performed to evacuate the hygroma and fenestrate the cyst. The researchers emphasize the importance of correct and timely diagnosis, as incidentally found arachnoid cysts may be the underlying cause of symptoms. They also highlight the need for a multistage therapeutic process and involving patients in decision-making. [Extracted from the article]
Published: 2023

104. Study Data from Meenakshi Mission Hospital Update Knowledge of Arachnoid Cysts (Giant interhemispheric arachnoid cyst - A rare case report).

Abstract: A recent study conducted at Meenakshi Mission Hospital in Madurai, India, focused on interhemispheric arachnoid cysts (IHACs), a rare type of congenital arachnoid cyst that accounts for 5% of cases. The study found that IHACs often present with symptoms such as macrocrania, seizures, infantile spasms, and developmental delay. The best surgical treatment for symptomatic IHACs is still debated, but both endoscopic cyst fenestration and shunt surgery have been found to be safe treatments. The study presented the case of an 11-month-old male infant with IHAC, corpus callosum agenesis, and hypoplasia in both frontal lobes, who underwent endoscopic cyst fenestration and cystoperitoneal shunt. [Extracted from the article]
Published: 2023

105. Researcher from University of Michigan Details Findings in Arachnoid Cysts (Sports Participation and Sports-Related Neurologic Injuries in Pediatric Patients With Arachnoid Cysts).

Abstract: Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Pediatrics; Surgery EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Pediatrics Surgery 1223 1223 1 11/06/23 20231110 NES 231110 2023 NOV 12 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Fresh data on arachnoid cysts are presented in a new report. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Pediatrics, Surgery Keywords for this news article include: University of Michigan, Ann Arbor, Michigan, United States, North and Central America, Surgery, Meninges, Pediatrics, Arachnoid Cysts, Health and Medicine, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. [Extracted from the article]
Published: 2023

106. Data from Universitas Tarumanagara Update Knowledge in Arachnoid Cysts (Quadrigeminal plate arachnoid cyst presenting with eye movement related migraine: a rare case report).

Abstract: Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Headache and Migraine; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Neurology; Primary Headache Diseases and Conditions EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Headache and Migraine Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Neurology Primary Headache Diseases and Conditions 312 312 1 11/06/23 20231106 NES 231106 2023 NOV 12 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Research findings on arachnoid cysts are discussed in a new report. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Headache and Migraine, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Neurology, Primary Headache Diseases and Conditions. [Extracted from the article]
Published: 2023

107. Department of Neurosurgery Researchers Describe New Findings in Arachnoid Cysts (Transventricular transforaminal endoscopic fenestration with cysto-ventriculoperitoneal shunt to manage a third ventricular arachnoid cyst: a case report).

Subjects: ARACHNOID cysts, CENTRAL nervous system, NEUROLOGICAL disorders, RESEARCH personnel, CENTRAL nervous system diseases, CENTRAL nervous system tumors
Abstract: Keywords: Arachnoid; Arachnoid Cysts; Cardiology; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations EN Arachnoid Arachnoid Cysts Cardiology Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations 238 238 1 10/30/23 20231030 NES 231030 2023 OCT 30 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- New research on arachnoid cysts is the subject of a new report. Arachnoid Cysts, Arachnoid, Cardiology, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Central Nervous System Neoplasms. [Extracted from the article]
Published: 2023

108. Findings from Minas Gerais in Arachnoid Cysts Reported (Arachnoid cysts of the quadrigeminal cistern: Proposal of a therapeutic algorithm based on a systematic review of literature).

Abstract: Keywords: Algorithms; Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Drugs and Therapies; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations EN Algorithms Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Drugs and Therapies Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations 781 781 1 10/24/23 20231027 NES 231027 2023 OCT 27 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- A new study on arachnoid cysts is now available. Algorithms, Arachnoid Cysts, Arachnoid, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Drugs and Therapies, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations Keywords for this news article include: Department of Pediatric Neurosurgery, Minas Gerais, Brazil, South America, Meninges, Algorithms, Arachnoid Cysts, Drugs and Therapies, Health and Medicine, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. [Extracted from the article]
Published: 2023

109. Research on Arachnoid Cysts Detailed by Researchers at Department of Pediatric Surgery (Current practices in temporal arachnoid cysts: a survey among Brazilian neurosurgeons).

Abstract: Keywords for this news article include: Department of Pediatric Surgery, Meninges, Technology, Arachnoid Cysts, Health and Medicine, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Technology Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Technology EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Technology 864 864 1 10/24/23 20231026 NES 231026 2023 OCT 29 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Investigators publish new report on arachnoid cysts. [Extracted from the article]
Published: 2023

110. Fernandes Figueira Institute Researchers Have Published New Data on Arachnoid Cysts (Intracranial arachnoid cysts: special issue).

Abstract: Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Epidemiology; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Pediatric Neurosurgery; Pediatrics; Risk and Prevention; Surgery EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Epidemiology Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Pediatric Neurosurgery Pediatrics Risk and Prevention Surgery 363 363 1 10/24/23 20231026 NES 231026 2023 OCT 29 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- A new study on arachnoid cysts is now available. Keywords for this news article include: Fernandes Figueira Institute, Meninges, Epidemiology, Arachnoid Cysts, Health and Medicine, Risk and Prevention, Pediatric Neurosurgery, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Epidemiology, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Pediatric Neurosurgery, Pediatrics, Risk and Prevention, Surgery. [Extracted from the article]
Published: 2023

111. Data on Arachnoid Cysts Published by Researchers at Federal University of Minas Gerais (Natural history of non-traumatic intracranial arachnoid cysts: a literature review).

Abstract: Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Risk and Prevention EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Risk and Prevention 229 229 1 10/24/23 20231023 NES 231023 2023 OCT 23 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Researchers detail new data in arachnoid cysts. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Risk and Prevention. [Extracted from the article]
Published: 2023

112. Studies Conducted at Hospital Sao Rafael on Arachnoid Cysts Recently Published (Interhemispheric arachnoid cysts: case series).

Subjects: CENTRAL nervous system, ARACHNOID cysts, NEUROLOGICAL disorders, CENTRAL nervous system diseases, CENTRAL nervous system tumors, CORPUS callosum
Abstract: Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Congenital Abnormalities; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Pediatrics EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Congenital Abnormalities Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Pediatrics 813 813 1 10/24/23 20231023 NES 231023 2023 OCT 23 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Investigators discuss new findings in arachnoid cysts. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Congenital Abnormalities, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Pediatrics Keywords for this news article include: Hospital Sao Rafael, Meninges, Pediatrics, Arachnoid Cysts, Health and Medicine, Congenital Abnormalities, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. [Extracted from the article]
Published: 2023

113. Researcher at All India Institute of Medical Sciences (AIIMS) Has Published New Study Findings on Arachnoid Cysts (Multiple Symptomatic Spinal Intradural Arachnoid Cysts: A Case Report).

Abstract: Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations 655 655 1 10/03/23 20231006 NES 231006 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- New research on arachnoid cysts is the subject of a new report. Arachnoid, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Arachnoid Cysts. [Extracted from the article]
Published: 2023

114. New Arachnoid Cysts Study Results from Cohen Children's Medical Center Described (Arachnoid cysts in paediatrics).

Subjects: ARACHNOID cysts, CENTRAL nervous system, MEDICAL centers, NEUROLOGICAL disorders, PEDIATRICS, CENTRAL nervous system tumors
Abstract: Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Epidemiology; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Neuroimaging; Pediatrics EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Epidemiology Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Neuroimaging Pediatrics 202 202 1 10/03/23 20231003 NES 231003 2023 OCT 7 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Imaging Week -- New research on arachnoid cysts is the subject of a new report. Keywords for this news article include: Cohen Children's Medical Center, Meninges, Pediatrics, Epidemiology, Neuroimaging, Arachnoid Cysts, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Epidemiology, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Neuroimaging, Pediatrics. [Extracted from the article]
Published: 2023

115. Research from King's College Hospital London Has Provided New Study Findings on Arachnoid Cysts (Long-Term Recurrent Intramedullary Arachnoid Cyst: Case Report and Literature Review).

Subjects: LITERATURE reviews, ARACHNOID cysts, CENTRAL nervous system, FAMILIAL spastic paraplegia, NEUROLOGICAL disorders, CENTRAL nervous system tumors, CENTRAL nervous system diseases
Abstract: Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations 1139 1139 1 10/03/23 20231003 NES 231003 2023 OCT 2 (NewsRx) -- By a News Reporter-Staff News Editor at Clinical Trials Week -- New study results on arachnoid cysts have been published. Arachnoid Cysts, Arachnoid, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations. [Extracted from the article]
Published: 2023

116. Researchers at University of Warmia and Mazury Olsztyn Publish New Data on Arachnoid Cysts (A quadrigeminal arachnoid cyst as a cause of neurological symptoms in an 11-month-old Brussels Griffon - A case study).

Abstract: Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations 705 705 1 09/19/23 20230923 NES 230923 2023 SEP 18 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- A new study on arachnoid cysts is now available. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations Keywords for this news article include: University of Warmia and Mazury Olsztyn, Olsztyn, Poland, Europe, Meninges, Arachnoid Cysts, Health and Medicine, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. [Extracted from the article]
Published: 2023

117. Researchers from University of Bologna Discuss Findings in Colloid Cysts (Isolated Entrapment of the Lateral Ventricle After Neuroendoscopic Resection of Colloid Cysts: Single-center Experience and Management).

Abstract: Italy, Europe, Central Nervous System, Central Nervous System Cysts, Central Nervous System Neoplasms, Cerebral Ventricles, Bologna, Colloid Cysts, Nervous System Diseases and Conditions, Nervous System Malformations, Lateral Ventricles Keywords: Bologna; Italy; Europe; Central Nervous System; Central Nervous System Cysts; Central Nervous System Neoplasms; Cerebral Ventricles; Colloid Cysts; Lateral Ventricles; Nervous System Diseases and Conditions; Nervous System Malformations EN Bologna Italy Europe Central Nervous System Central Nervous System Cysts Central Nervous System Neoplasms Cerebral Ventricles Colloid Cysts Lateral Ventricles Nervous System Diseases and Conditions Nervous System Malformations 1114 1114 1 09/11/23 20230911 NES 230911 2023 SEP 11 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Researchers detail new data in Nervous System Diseases and Conditions - Colloid Cysts. Keywords for this news article include: Bologna, Italy, Europe, Central Nervous System, Central Nervous System Cysts, Central Nervous System Neoplasms, Cerebral Ventricles, Colloid Cysts, Lateral Ventricles, Nervous System Diseases and Conditions, Nervous System Malformations, University of Bologna. [Extracted from the article]
Published: 2023

118. Study Findings from University of Southern California (USC) Provide New Insights into Colloid Cysts (Exoscope-assisted, Channel-based Approach for Resection of 3rd Ventricular Colloid Cyst: 2-dimensional Operative Video).

Abstract: Keywords: Los Angeles; State:California; United States; North and Central America; Brain Diseases and Conditions; Cardiology; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Colloid Cysts; Health and Medicine; Hydrocephalus; Intracranial Hypertension; Nervous System Diseases and Conditions; Nervous System Malformations EN Los Angeles State:California United States North and Central America Brain Diseases and Conditions Cardiology Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Colloid Cysts Health and Medicine Hydrocephalus Intracranial Hypertension Nervous System Diseases and Conditions Nervous System Malformations 1286 1286 1 09/11/23 20230911 NES 230911 2023 SEP 11 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- Researchers detail new data in Nervous System Diseases and Conditions - Colloid Cysts. Keywords for this news article include: Los Angeles, California, United States, North and Central America, Brain Diseases and Conditions, Cardiology, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Colloid Cysts, Health and Medicine, Hydrocephalus, Intracranial Hypertension, Nervous System Diseases and Conditions, Nervous System Malformations, University of Southern California (USC). [Extracted from the article]
Published: 2023

119. Studies from Kirsehir Ahi Evran University Reveal New Findings on Arachnoid Cysts (Giant Arachnoid Cyst With Spontaneous Shrinking: A Case Report).

Abstract: Keywords for this news article include: Kirsehir Ahi Evran University, Kirsehir, Turkey, Eurasia, Meninges, Arachnoid Cysts, Health and Medicine, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations 1254 1254 1 09/04/23 20230908 NES 230908 2023 SEP 4 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators discuss new findings in arachnoid cysts. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations. [Extracted from the article]
Published: 2023

120. New Arachnoid Cysts Research from Kindai University Described (Successful Endoscopic Surgery Under Stereotactic Navigation for a Symptomatic Interhemispheric Arachnoid Cyst Without the Agenesis of the Corpus Callosum in an Elderly Patient: A...).

Abstract: Keywords for this news article include: Kindai University, Osaka, Japan, Asia, Brain, Surgery, Meninges, Telencephalon, Arachnoid Cysts, Corpus Callosum, Health and Medicine, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. Arachnoid, Arachnoid Cysts, Brain, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Corpus Callosum, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Surgery, Telencephalon Keywords: Arachnoid; Arachnoid Cysts; Brain; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Corpus Callosum; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Surgery; Telencephalon EN Arachnoid Arachnoid Cysts Brain Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Corpus Callosum Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Surgery Telencephalon 644 644 1 08/28/23 20230901 NES 230901 2023 SEP 3 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Investigators publish new report on arachnoid cysts. [Extracted from the article]
Published: 2023

121. Epidermoid cyst of the posterior fossa: a case report Cisto epidermoide da fossa posterior: relato de caso

Author: Eduardo Cambruzzi, Karinelli Presa, Luciano Carvalho Silveira, and Gerson Evandro Perondi
Subjects: Cisto epidérmico, Neoplasias encefálicas, Ângulo cerebelopontino, Patologia, Cistos do sistema nervoso central, Epidermal cyst, Brain neoplasms, Cerebellopontine angle, Pathology, Central nervous system cysts, RB1-214
Abstract: Epidermoid cysts of the central nervous system are uncommon conditions, which are frequently located in the cerebellopontine angle and around the pons. They are covered with keratinized squamous epithelium and keratin lamella, which give its contents a soft, white-pearly appearance. Epidermoid cysts are mostly originated from malformations, presumably associated with surface elements of the nervous system ectoderm during the closure of the neural groove or formation of secondary cerebral vesicles. The authors describe a case of epidermoid cyst in the posterior fossa causing hydrocephalus and review morphologic and diagnostic criteria of this lesion.Os cistos epidermoides do sistema nervoso central (SNC) são condições incomuns, estando localizados mais frequentemente no ângulo pontocerebelar e ao redor da ponte. Eles são revestidos por epitélio escamoso queratinizado e lamelas de queratina, tornando seu conteúdo branco-perolado e pastoso. Os cistos epidermoides são, na maioria das vezes, originados de malformações, possivelmente associados ao entremeio de elementos superficiais do ectoderma do SNC durante o fechamento da placa neural, ou formação das vesículas cerebrais secundárias. Os autores descrevem um caso de cisto epidermoide da fossa posterior determinando hidrocefalia e revisam critérios morfológicos e diagnósticos dessa lesão.
Published: 2011
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122. Primary collision tumors of the sellar region: Experience from a single center

Author: Li Gong, Huangtao Chen, Wendong Zhang, Xiaoyan Liu, Yuanyuan Wang, Xiaorong Mu, Fuqin Zhang, Qing Li, Lijun Heng, and Wei Zhang
Subjects: Adenoma, Adult, Male, Ganglioneuroma, General Medicine, Middle Aged, Kidney Neoplasms, Craniopharyngioma, Young Adult, Neurology, Physiology (medical), Meningeal Neoplasms, Humans, Surgery, Female, Pituitary Neoplasms, Neurology (clinical), Central Nervous System Cysts, Meningioma, Carcinoma, Renal Cell, Aged, Retrospective Studies
Abstract: Collision tumors are extremely rare in the sellar region, and their features have not been fully characterized. Here, we report our single-center experience in the diagnosis and management of these tumors, focusing primarily on their clinicopathological features. We first performed a retrospective study of pathological reports from patients who had undergone surgery for pituitary adenoma (PA) or craniopharyngioma (CP) at our hospital. Next, to identify collision tumors, patients with a second pathological diagnosis-such as Rathke's cleft cyst (RCC), gangliocytoma (GC), meningioma, or atypical teratoid/rhabdoid tumor (AT/RT)-were considered. Finally, the clinicopathological characteristics of these tumors were reviewed and analyzed. The results demonstrated that eleven of 2359 PA or CP cases (0.47 %) were found to exhibit sellar collision tumors; the patient cohort had a median age of 52 years (23-71) and was predominantly female (63.6 %, 7/11). In details, of the 2092 cases of PA, 10 were diagnosed with concurrent lesions (seven of RCC and one each of CP, meningioma, and GC). Of the 267 CP cases, a single patient presented with associated AT/RT. To our knowledge, this is the first reported adult case of this subtype. Notably, the preoperative CT and/or MRI of each patient revealed solely PA or CP. The endoscopic endonasal approach was the preferred surgery. In conclusion, the sellar collision tumors occur with low incidence, and the primary subtype is PA and RCC. Their definitive diagnosis depends primarily on pathological findings.
Published: 2022

123. Impaired catabolism of free oligosaccharides due to MAN2C1 variants causes a neurodevelopmental disorder

Author: Nuno Maia, Sven Potelle, Hamide Yildirim, Sandrine Duvet, Shyam K. Akula, Celine Schulz, Elsa Wiame, Alexander Gheldof, Katherine O’Kane, Abbe Lai, Karen Sermon, Maïa Proisy, Philippe Loget, Tania Attié-Bitach, Chloé Quelin, Ana Maria Fortuna, Ana Rita Soares, Arjan P.M. de Brouwer, Emile Van Schaftingen, Marie-Cécile Nassogne, Christopher A. Walsh, Katrien Stouffs, Paula Jorge, Anna C. Jansen, François Foulquier, Public Health Sciences, Faculty of Medicine and Pharmacy, Neurogenetics, Clinical sciences, Medical Genetics, Basic (bio-) Medical Sciences, Reproduction and Genetics, Centre for Medical Genetics, Mental Health and Wellbeing research group, Neuroprotection & Neuromodulation, Universidade do Minho = University of Minho [Braga], Unité de Glycobiologie Structurale et Fonctionnelle UMR 8576 (UGSF), Université de Lille-Centre National de la Recherche Scientifique (CNRS), Université de Lille, CNRS, and Unité de Glycobiologie Structurale et Fonctionnelle (UGSF) - UMR 8576
Subjects: Male, Adolescent, Child, preschool, glycosylation, [SDV]Life Sciences [q-bio], Hamartoma, Hypothalamus, Oligosaccharides, Hamartoma/genetics, Brain Stem/metabolism, Congenital Disorders of Glycosylation, All institutes and research themes of the Radboud University Medical Center, Tongue, alpha-Mannosidase, Intellectual Disability, Cell Line, Tumor, Leukocytes, Genetics, Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase, Humans, Central Nervous System Cysts/genetics, Central Nervous System Cysts, Child, Genetics (clinical), Alleles, Peptide-N4-(N-acetyl-beta-glucosaminyl) Asparagine Amidase/deficiency, Neurodevelopmental disorders Donders Center for Medical Neuroscience [Radboudumc 7], Oligosaccharides/metabolism, Congenital Disorders of Glycosylation/genetics, Hypothalamus/metabolism, alpha-Mannosidase/deficiency, Cerebellar Vermis/metabolism, Intellectual Disability/genetics, Mannose/metabolism, fetus, Polymicrogyria/genetics, Polymicrogyria, Leukocytes/metabolism, Female, Tongue/metabolism, Mannose, Brain Stem, Cerebellar Vermis
Abstract: International audience; Free oligosaccharides (fOSs) are soluble oligosaccharide species generated during N-glycosylation of proteins. Although little is knownabout fOS metabolism, the recent identification of NGLY1 deficiency, a congenital disorder of deglycosylation (CDDG) caused by loss offunction of an enzyme involved in fOS metabolism, has elicited increased interest in fOS processing. The catabolism of fOSs has beenlinked to the activity of a specific cytosolic mannosidase, MAN2C1, which cleaves a1,2-, a1,3-, and a1,6-mannose residues. In this study,we report the clinical, biochemical, and molecular features of six individuals, including two fetuses, with bi-allelic pathogenic variants inMAN2C1; the individuals are from four different families. These individuals exhibit dysmorphic facial features, congenital anomaliessuch as tongue hamartoma, variable degrees of intellectual disability, and brain anomalies including polymicrogyria, interhemisphericcysts, hypothalamic hamartoma, callosal anomalies, and hypoplasia of brainstem and cerebellar vermis. Complementation experimentswith isogenic MAN2C1-KO HAP1 cells confirm the pathogenicity of three of the identified MAN2C1 variants. We further demonstratethat MAN2C1 variants lead to accumulation and delay in the processing of fOSs in proband-derived cells. These results emphasize theinvolvement of MAN2C1 in human neurodevelopmental disease and the importance of fOS catabolism.
Published: 2022
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124. Arachnoidal Diverticula of Sacral Extradural Meningeal Cyst: A Novel Definition and Case Series

Author: Qianquan Ma, Chao Wu, Jia Zhang, Xiaoliang Yin, Chenlong Yang, Yu Si, Haibo Wu, Qiang Zhao, Ying Liu, Huishu Yuan, Qing Chang, Jingcheng Xie, Jun Yang, and Jianjun Sun
Subjects: Arachnoid Cysts, Diverticulum, Sacrum, Sacrococcygeal Region, Humans, Pain, Surgery, Neurology (clinical), Central Nervous System Cysts, Tarlov Cysts
Abstract: Sacral cysts are classically divided into Tarlov cysts and meningeal diverticula. However, the pathogenesis of sacral cysts remains unclear. This study aimed to clarify a novel type of sacral extradural spinal meningeal cyst with a specific arachnoidal structure.Nine patients with prophylactic diverticula were included in the study. All patients underwent MRI preoperative reconstruction and traditional neck transfixation.All patients presented with more than one symptom. The major symptom was lower extremity pain, followed by lower extremity numbness (77.8%, 7/9), lower extremity weakness (55.6%, 5/9), bowel/bladder and sexual dysfunction (55.6%, 5/9), and tenesmus (22.2%, 2/9). After long-term follow-up, the outcome was classified as improved in 9 patients (100%).The clinical findings of this study illustrate a special subtype and may help explain the mechanism of sacral cyst formation.
Published: 2022

125. Leukoencephalopathy with brain calcifications and cysts (Labrune syndrome) case report: diagnosis and management of a rare neurological disease

Author: Michelle Paff, Nardin Samuel, Noor Alsafwani, Darcia Paul, Phedias Diamandis, Seth A. Climans, Walter Kucharczyk, Mandy Yi Rong Ding, Andrew F. Gao, and Andres M. Lozano
Subjects: Adult, Cysts, Calcinosis, General Medicine, Magnetic Resonance Imaging, White Matter, Intracranial cysts, Intracranial calcifications, Leukoencephalopathies, Case report, Humans, Female, Labrune syndrome, Neurology. Diseases of the nervous system, Neurology (clinical), Central Nervous System Cysts, RC346-429, Leucoencephalopathy
Abstract: Background Leukoencephalopathy with brain calcifications and cysts (LCC; also known as Labrune syndrome) is a rare genetic microangiopathy caused by biallelic mutations in SNORD118. The mechanisms by which loss-of-function mutations in SNORD118 lead to the phenotype of leukoencephalopathy, calcifications and intracranial cysts is unknown. Case presentation We present the histopathology of a 36-year-old woman with ataxia and neuroimaging findings of diffuse white matter abnormalities, cerebral calcifications, and parenchymal cysts, in whom the diagnosis of LCC was confirmed with genetic testing. Biopsy of frontal white matter revealed microangiopathy with small vessel occlusion and sclerosis associated with axonal loss within the white matter. Conclusions These findings support that the white matter changes seen in LCC arise as a consequence of ischemia rather than demyelination.
Published: 2022
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126. T2 hypointense signal discovered incidentally at the posterior edge of the adenohypophysis on MRI: its prevalence and morphology and their relationship to age

Author: Aiko Gobara, Takashi Katsube, Hiroya Asou, Rika Yoshida, Takeshi Yoshizako, and Hajime Kitagaki
Subjects: Adult, Aged, 80 and over, Adolescent, Middle Aged, Magnetic Resonance Imaging, Young Adult, Pituitary Gland, Anterior, Child, Preschool, Prevalence, Humans, Radiology, Nuclear Medicine and imaging, Neurology (clinical), Cardiology and Cardiovascular Medicine, Central Nervous System Cysts, Child, Aged
Abstract: T2 hypointense signal at the posterior edge of the adenohypophysis (T2HSPA) on magnetic resonance imaging (MRI) is incidentally encountered. We aimed to investigate the prevalence and morphology of T2HSPA and their relationship to age.A total of 212 cases between 3 and 88 years old were examined. Sagittal T2-weighted image (T2WI) was evaluated for the presence of T2HSPA, which classified by its morphology into two types (belt-like or nodal). The Wilcoxon rank sum test and chi-square test were used to evaluate the differences between the groups. The T2HSPA was extracted by ImageJ software and measured as a cross-sectional area (CSA) quantitatively by threshold setting. We examined the relationship between CSA of T2HSPA and age, and Spearman's correlation coefficients were used for statistical analysis.Of the 212 cases, 80 (37.7%) were identified with T2HSPA. The groups with T2HSPA were significantly younger than the groups without it (p = .01). Groups with belt-like T2HSPA were significantly younger than the groups with nodal T2HSPA (p = .01). There was a weak negative correlation between CSA of T2HSPA and age (p = .02).T2HSPAs were incidentally detected in 37.7% of all cases, tended to be more common in younger cases, and their morphology was related to age. They seem to have little clinical significance as they tend to decrease in size with age.
Published: 2022

127. [Central diabetes insipidus after resection of sellar-suprasellar tumors: prevalence and predictors of manifestation]

Author: I.N. Badmaeva, L.I. Astafieva, P.L. Kalinin, B.A. Kadashev, and M.A. Kutin
Subjects: Diabetes Insipidus, Neurogenic, Craniopharyngioma, Diabetes Mellitus, Prevalence, Humans, Pituitary Neoplasms, Neurology (clinical), Central Nervous System Cysts
Abstract: Central diabetes insipidus is a neuroendocrine disorder caused by disturbances in antidiuretic hormone release. The last one is responsible for fluid and electrolyte balance regulation. The most common cause of diabetes insipidus is resection of sellar-suprasellar tumors followed by damage to hypothalamic nuclei responsible for antidiuretic hormone release, disruption of antidiuretic hormone transportation from hypothalamus or its release by neurohypophysis. According to various data, postoperative diabetes insipidus occurs in 13-30% of cases. The highest risk of diabetes insipidus is observed after resection of craniopharyngioma, Rathke's cleft cyst and ACTH-releasing pituitary microadenoma. This review is devoted to prevalence and predictors of diabetes insipidus after resection of sellar-suprasellar tumors.Центральный несахарный диабет (ЦНД) — это нейроэндокринное заболевание, обусловленное нарушением секреции антидиуретического гормона (АДГ), регулирующего водно-электролитный баланс в организме. Наиболее распространенной его причиной является нейрохирургическое удаление опухолей хиазмально-селлярной области (ХСО), в ходе которого возможно повреждение ядер гипоталамуса, секретирующих АДГ, прерывание его транспорта из гипоталамуса или нарушение его высвобождения из нейрогипофиза. По данным различных исследований, послеоперационный ЦНД встречается в 13—30% случаев. Наиболее высокий риск его развития отмечается после удаления краниофарингиом, кист кармана Ратке и микроаденом гипофиза, секретирующих адренокортикотропный гормон. В представленном обзоре литературы проанализированы распространенность и предикторы развития несахарного диабета после удаления опухолей ХСО.
Published: 2021

128. [Collision sellar lesions: pituitary adenoma and Rathke cleft cyst]

Author: Fernando, Padilla Lichtenberger, Mariela, Glerean, Andrea, Paissan, and Pablo, Ajler
Subjects: Adenoma, Adult, Pituitary Gland, Humans, Female, Pituitary Neoplasms, Central Nervous System Cysts, Magnetic Resonance Imaging
Abstract: Rathke's cleft cyst (RCC) are a slow-growing, benign, cystic lesions that arises from the remnants of the primitive ectoderm and Rathke's pouch. They present a common origin with pituitary adenomas (PA), however, the concomitant presentation of a PA and a RCC rarely occur. We present a case of a 41-year-old female with Cushing's disease. Magnetic resonance imaging (MRI) showed two synchronic lesions in the sellar region. An endoscopic transnasal approach was performed, with complete excision of both. The histological studies revealed an ACTH secreting PA and a RCC. The patient presented clinical and endocrinological remission six months after surgery. With the presence of cystic lesion at the sellar region, and the concomitant finding of a pituitary adenoma, RCC should be considered.El quiste de la bolsa de Rathke (QBR) es una entidad benigna de crecimiento lento que proviene del remanente del ectodermo primitivo. Presenta un origen común con los adenomas hipofisarios (AH), sin embargo, la presentación sincrónica de un AH y un QBR es infrecuente. Presentamos el caso de una mujer de 41 años con enfermedad de Cushing. Se realizó resonancia magnética con el hallazgo de dos lesiones en región selar. Se hizo un abordaje transnasal endoscópico, con exéresis completa de ambas. El informe de anatomía patológica reveló un AH corticotropo y un QBR. Tuvo una remisión clínica analítica endocrinológica a los seis meses postquirúrgicos. Ante el hallazgo de una imagen quística a nivel selar concomitante con un adenoma hipofisario, debe ser considerada la posibilidad diagnóstica de un QBR.
Published: 2021

129. The surgical outcomes following transsphenoidal surgery for Rathke cleft cysts: Comparison of the surgical approaches at a single institution

Author: Yoon-Hee, Choo, Youngbeom, Seo, and Oh Lyong, Kim
Subjects: Male, Cohort Studies, Treatment Outcome, Cysts, Humans, Female, General Medicine, Middle Aged, Central Nervous System Cysts, Retrospective Studies
Abstract: The aim of the present study is to retrospectively analyze the surgical outcomes and complications of microscopic and endoscopic transsphenoidal surgery in the management of Rathke cleft cysts (RCCs) at a single institution. A total of 38 patients were enrolled in this study. All patients were diagnosed with RCCs, which were confirmed histopathologically. Endocrine function, radiological, and clinical outcomes were evaluated following surgery. This cohort study consisted of 16 male and 22 female patients. The median age was 48 years (range, 21-72). The median clinical follow-up duration was 57 months (range, 3-187). Twenty-five patients underwent microscopic transsphenoidal surgery and 13 patients underwent endoscopic surgery. The cysts were located within the intrasellar area in 18 (47.4%) patients, and extended to the suprasellar area in 20 (52.6%) patients. The radiological characteristics were similar in the microscope and endoscope groups, except mass volume (1.40 vs 0.65 mm3; P = .003) and peripheral rim enhancement (P = .036). After surgery, 30 (78.9%) of the 38 patients had no residual cysts. There was no significant difference in outcomes between both groups (76.0% vs 84.6%; P = .689). Four (10.5%) patients experienced cyst recurrence in only the microscope group. Twenty-four of the 25 patients who presented with headache showed improvement after surgery. Four patients with visual field defects recovered after surgery. Among the 8 patients with hormonal deficiencies, hormone levels normalized in 5 patients, did not change in 2 patients and worsened in 1 patient. New hormonal deficiencies occurred in 3 patients. Microscopic or endoscopic transsphenoidal surgery for RCCs is a safe and effective treatment option. Complete aspiration of the cyst contents with wide fenestration and wall biopsy, regardless of the surgical approach used, is usually a sufficient treatment for RCCs.
Published: 2022
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130. Fetal Infection by Zika Virus in the Third Trimester: Report of 2 Cases.

Author: de Souza, Antonio Soares, Moraes Dias, Cristiane, Braojos Braga, Fernanda Del Campo, Bernardes Terzian, Ana Carolina, Fernanda Estofolete, Cássia, Hélio Oliani, Antonio, Henrique Oliveira, Gustavo, de Mattos, Cinara Cássia Brandão, de Mattos, Luiz Carlos, Nogueira, Maurício Lacerda, and Mós Vaz-Oliani, Denise Cristina
Subjects: *ZIKA virus, *PREGNANCY complications, *MICROCEPHALY, *BRAIN injuries, *CYSTS (Pathology)
Abstract: Zika virus (ZIKV) infection acquired during pregnancy is associated with congenital microcephaly. We describe 2 cases of ZIKV infection in women in their 36th week of pregnancy whose fetuses had preserved head circumference at birth and findings of subependymal cysts and lenticulostriate vasculopathy in postnatal imaging. These represent the first signs of congenital brain injury acquired due to ZIKV in the third trimester. [ABSTRACT FROM AUTHOR]
Published: 2016
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131. A huge brain cyst in left temporal fossa

Author: Muhammad Faisal Khilji and Abdullah Al-Reesi
Subjects: Epidermal cyst, Tomography, X-ray computed, Magnetic resonance imaging, Central nervous system cysts, Case reports, Neurology. Diseases of the nervous system, RC346-429
Abstract: A 27-year-old male with left temporal protrusion from childhood presented with complaints of headache, nausea and vomiting. Cranial magnetic resonance imaging (MRI) showed fluid collection measuring 6.00 cm × 7.00 cm × 8.00 cm in left temporal fossa. The diagnosis of epidermoid cyst of brain was made and surgical resection of the tumor was done. Epidermoid cysts of brain grow slowly and are composed of epidermoid cells debris rich in cholesterol. The prophylactic removal of these tumors with goal of preventing recurrence is recommended.
Published: 2013

132. Surgical outcomes and quality of life in Rathke's cleft cysts undergoing endoscopic transsphenoidal resection: a multicentre study and systematic review of the literature

Author: Mendel Castle-Kirszbaum, Jeremy Kam, Yi Yuen Wang, James King, Kylie Fryer, and Tony Goldschlager
Subjects: Male, Endocrinology, Treatment Outcome, Endocrinology, Diabetes and Metabolism, Quality of Life, Humans, Multicenter Studies as Topic, Endoscopy, Female, Pituitary Neoplasms, Middle Aged, Central Nervous System Cysts, Retrospective Studies
Abstract: To establish the effect of endoscopic endonasal surgery (EES) on quality-of-life (QoL) in symptomatic Rathke cleft cyst (RCC).Analysis of 38 patients with RCC treated by EES, with regular overall (ASBQ-35) and sinonasal-specific (SNOT-22) QoL assessment during the first postoperative year. A systematic literature review of large case series was performed with pooled analysis.In our series, mean age was 53.6 years with a female predominance (73.7%). Larger cysts were seen in males (p 0.01), those with hypogonadism (p = 0.04), and visual dysfunction (p = 0.04). Complete normalisation of vision was seen in 83.3%. Persistence of visual dysfunction postoperatively was associated with diabetes (p = 0.005), hypertension (p = 0.02), suprasellar only location (p = 0.001), and monocular field cut (p = 0.02). Surgery did not significantly effect hormonal function. Sinonasal QoL transiently worsened after surgery, resolving within 3 weeks. A parallel transient worsening of overall QoL normalised by 6 weeks, and remained at preoperative baseline thereafter. These results were comparable to the literature, where 76.4% demonstrated improvement of vision and 13.1% had recurrence after treatment. There was no significant difference in outcomes between EES and microscopic approaches.We report longitudinal QoL outcomes in RCC for the first time. Vision commonly improves with surgery, but endocrinopathy is likely to persist. Microvascular risk-factors may compromise visual improvement. Surgery causes a transient worsening of sinonasal symptoms that resolves within 3-6 weeks, but patients may not experience significant improvement in QoL within the first postoperative year.
Published: 2021

133. Vanishing Rathke's cleft cyst

Author: Le Uyen France Truong, Benoît Marlier, Bénédicte Decoudier, Claude Fabien Litré, and Sara Barraud
Subjects: Endocrinology, Endocrinology, Diabetes and Metabolism, Humans, Pituitary Neoplasms, General Medicine, Central Nervous System Cysts
Published: 2021

134. Long-Term Outcomes of Endoscopic Cyst Fenestration for Rathke Cleft Cyst

Author: Hiroki Yamada, Ryo Ueda, Hiroyuki Ozawa, and Masahiro Toda
Subjects: Male, Cerebrospinal Fluid Leak, Cysts, Headache, Humans, Surgery, Female, Neurology (clinical), Central Nervous System Cysts, Carcinoma, Renal Cell, Kidney Neoplasms
Abstract: We sought to elucidate the long-term surgical outcomes and incidence of recurrence and reoperation of endoscopic endonasal cyst fenestration for Rathke cleft cyst (RCC).A retrospective review of the chart and operation record of RCC surgical cases between January 2008 and August 2021 at our institution was conducted. Patient characteristics, intraoperative findings, and postoperative follow-up outcomes were evaluated.A total of 27 patients were analyzed, with a median postoperative follow-up period of 52 months (range, 1-150 months). Preoperative symptoms were visual dysfunction (59%), headache (41%), and pituitary dysfunction (22%). Endoscopic cyst fenestration was performed in all patients. Ten (37%) patients had intraoperative cerebrospinal fluid leakage. Among them, the only patient in whom sellar floor reconstruction was not performed experienced a repair operation due to postoperative cerebrospinal fluid leakage. No patients experienced postoperative hypopituitarism. Preoperative headache, visual dysfunction, and pituitary hormone disorder improved in 73%, 75%, and 67% of patients, respectively. Although postoperative cyst regrowth was observed in 8 patients (30%), no patient experienced worsening or novel symptoms and none required reoperation.Patients with a symptomatic RCC can be effectively treated with endoscopic endonasal cyst fenestration. Reversal of the presenting symptoms resulted, including headache, visual dysfunction, and pituitary hormone dysfunction, in the majority of patients. In our series, appropriate reconstruction of the sellar floor reduced the risk of postoperative cerebrospinal fluid leakage without impacting cyst regrowth. This simple technique appears to effectively disrupt cyst progression in most cases, even after a relatively long-term follow-up period.
Published: 2021

135. A Single Vertebral Surgical Approach for Spinal Extradural Meningeal Cysts Spanning Multiple Vertebral Segments by Auxiliary Neuroendoscope

Author: Taohui Ouyang, Wei Meng, Lichao Wang, Meihua Li, Tao Hong, and Na Zhang
Subjects: Arachnoid Cysts, Neuroendoscopes, Laminectomy, Humans, Surgery, Neurology (clinical), Central Nervous System Cysts, Magnetic Resonance Imaging, Spinal Cord Diseases, Thoracic Vertebrae
Abstract: Spinal extradural meningeal cysts (SEMCs) are rare lesions, especially those spanning multiple vertebral segments, and the surgical strategy has remained controversial. In the present study, we have described the outcomes of 4 patients with SEMCs treated with dural defect repair alone assisted by neuroendoscopy.From January 2018 to January 2020, 4 patients with SEMCs spanning multiple vertebral segments had undergone single-vertebral laminectomy or hemilaminectomy.The SEMCs in all 4 patients had spanned multiple vertebral segments, from T11 to L2. Using magnetic resonance imaging, the location of the dural defect was predicted correctly for 3 patients. Single-vertebral laminectomy was used in 2 patients and single-vertebral hemilaminectomy in 2 patients. Intraoperatively, the entire cyst, including the upper pole, lower pole, and middle segment of the cyst, was explored using neuroendoscopy. In each patient, only 1 dural defect was found, which had been located in the middle segment of the cyst (T12-L1). All cyst dural defects had been sutured under a microscope. In all cases, the cyst wall was not removed. Postoperatively, the symptoms for all the patients had improved significantly, and subsequent magnetic resonance imaging studies showed obvious cyst regression. During the follow-up period of 15-44 months, no recurrence was observed.For SEMCs spanning multiple vertebral segments, dural defect repair without cyst wall resection through single-vertebral hemilaminectomy or laminectomy can be effective. Intraoperative neuroendoscopy can assist, not only in finding the dural defect, but also in avoiding the omission of multiple dural defects as much as possible.
Published: 2021

136. Analysis of the Clinical Characteristics and Pituitary Function of Patients in Central China With Rathke's Cleft Cysts

Author: Zhang, Lixia, Li, Xueyuan, Li, Chong, Wang, Zhifang, Zheng, Lili, Qin, Guijun, Wang, Shoujun, and Xu, Lijun
Subjects: Male, Endocrinology, Diabetes and Metabolism, Pituitary Diseases, Dizziness, Kidney Neoplasms, Cortisone, Adrenocorticotropic Hormone, Pituitary Gland, Humans, Female, Pituitary Neoplasms, Central Nervous System Cysts, Carcinoma, Renal Cell, Retrospective Studies
Abstract: ObjectiveA Rathke’s cleft cyst (RCC) is a common, benign, cystic disease that often leads to hypophyseal dysfunction or head symptoms. The relationship between RCCs and pituitary gland function is not clear. We therefore carried out a study to examine this relationship in greater detail.MethodsThe study was a retrospective, cohort design in patients diagnosed with a RCC between January 2019 to July 2021 at the First Affiliated Hospital of Zhengzhou University, China.ResultsA total of 221 patients were enrolled and then divided into study cohorts according to the diameter of the RCC, clinical manifestations, and surgical treatment received. The majority of patients were symptomatic (143/221), including 83 cases of dizziness and headache, 9 of vision loss and visual field defect, and 2 of diabetes insipidus. 52 cases had abnormal pituitary function, with 8 cases interestingly showing high adrenocorticotropic-hormone (ACTH) and cortisone levels, while 8 juvenile cases had developed central precocious puberty. Patients with larger RCCs were more likely to present with headaches and dizziness, with subjects who suffered from these symptoms having high ACTH and cortisone levels.ConclusionAlthough the size of a RCC is not an important factor influencing hypopituitary function, we consider that endocrine evaluation should be carried out in all patients with a RCC.
Published: 2021

137. Coats plus syndrome: a rare cause of severe gastrointestinal tract bleeding in children - a case report

Author: Selcen Bozkurt, Ayse Merve Usta, Nafiye Urganci, Nida Gulderen Kalay, Gulsen Kose, and Evrim Ozmen
Subjects: Brain Neoplasms, Calcinosis, Retinal Diseases, Leukoencephalopathies, Muscle Spasticity, Seizures, Pediatrics, Perinatology and Child Health, Hypertension, Portal, Humans, Ataxia, Female, Central Nervous System Cysts, Child, Gastrointestinal Hemorrhage
Abstract: Background Coats plus syndrome, cerebroretinal microangiopathy with calcifications and cysts, is a rare disease with autosomal recessive pattern occurring due to a mutation in CTC1, encoding conserved telomere maintenance component 1, gene. Besides retinal involvement, abnormalities in brain and osteopenia, serious life-threatening bleeding in gastrointestinal tract and portal hypertension can be observed. Case presentation A 6-year-old girl with Coats plus syndrome presented to the pediatric emergency department with vomiting blood and blood in stool. An upper and lower gastrointestinal endoscopy revealed esophageal varices and vascular telangiectasia in the pyloric antrum, duodenum, and colon. She received palliative care and the bleeding was stopped after receiving intravenous octreotide. She then was followed in the pediatric gastroenterology, neurology, and ophthalmology clinics. She was later hospitalized and admitted to the intensive care unit as she continued to have intermittent gastrointestinal system bleeding. She eventually died due to severe gastrointestinal system bleeding. Conclusions Coats plus syndrome can lead to life-threatening gastrointestinal bleeding and portal hypertension. As Coats plus syndrome is quite rare, there is little published data on this syndrome. This report presents a case of Coats plus syndrome as a rare cause of gastrointestinal bleeding and portal hypertension.
Published: 2021

138. Natural history and surgical outcome of Rathke's cleft cysts-A study from the Swedish Pituitary Registry

Author: Britt Edén Engström, Anna-Karin Åkerman, Maria Petersson, Katarina Berinder, Oskar Ragnarsson, Martin Olsson, Peter Siesjö, Jeanette Wahlberg, Petter Förander, Sophie Bensing, Henrik Borg, Erika Tsatsaris, Pia Burman, Bertil Ekman, Per Dahlqvist, and Charlotte Höybye
Subjects: medicine.medical_specialty, Pituitary gland, cyst size, hypopituitarism, pituitary, Rathkes cleft cyst, transphenoidal surgery, visual impairment, Endocrinology, Diabetes and Metabolism, Visual impairment, Hypopituitarism, Endocrinology and Diabetes, Asymptomatic, Endocrinology, Internal medicine, Medicine, Humans, Cyst, Pituitary Neoplasms, Registries, Central Nervous System Cysts, Sweden, Rathke's cleft cyst, business.industry, Kirurgi, medicine.disease, Surgery, Visual field, Natural history, medicine.anatomical_structure, Treatment Outcome, Pituitary Gland, Endokrinologi och diabetes, Female, medicine.symptom, Neoplasm Recurrence, Local, business
Abstract: Objective Rathkes cleft cysts are benign, embryological remnants in the pituitary gland. The majority of them are small and asymptomatic but a few may become large, and cause mass effects, pituitary hormone deficiencies and visual impairment. Recommendations for the follow-up of Rathkes cleft cysts vary since data on the natural history are sparse. Patients and Design Data at diagnosis and at 1, 5 and 10 years for patients with a Rathkes cleft cyst (434 at diagnosis, 317 females) were retrieved from the Swedish Pituitary Registry. Cysts = 10 mm that were not operated (n = 174) decreased in size over the years (p < .01). Pituitary hormone deficiencies and visual impairments were more frequent (18% and 5.7%, respectively) but were stable over time. Transphenoidal surgery was performed in 56 patients of whom 51 underwent surgery before the 1-year follow-up. The mean cyst diameter at diagnosis was 18 mm (range: 930 mm), 36% had pituitary hormone deficiency, 45% had visual field defects and 20% had impaired visual acuity. One year after surgery 60% had no cyst remnants, 50% had a pituitary deficiency, 26% had visual field defects and 12% had impaired visual acuity. No major changes were observed after 5 years. Twelve of the operated patients had a follow-up at 10 years, in eight the cyst remnants or recurrences increased in size over time (p < .05). Conclusions Rathkes cleft cysts with a size less than 10 mm rarely grow and our results indicate that radiological follow-up can be restricted to 5 years. In contrast, progression of postoperative remnants or recurrent cysts is more likely and require long-term follow-up.
Published: 2021

139. Suprasellar Mature Cystic Teratoma Mimicking Rathke’s Cleft Cyst: A Case Report and Systematic Review of the Literature

Author: Renzhi Wang, Yan You, Shenzhong Jiang, Zhaojian Wang, and Xinjie Bao
Subjects: Adult, medicine.medical_specialty, endocrine system diseases, Endocrinology, Diabetes and Metabolism, medicine.medical_treatment, rare lesion, Mature Cystic Teratoma, Diseases of the endocrine glands. Clinical endocrinology, Resection, Diagnosis, Differential, mature cystic teratomas, Endocrinology, medicine, Humans, Sella Turcica, Cyst, Central Nervous System Cysts, Original Research, neuropathology, Rathke's cleft cyst, sellar region, business.industry, Teratoma, Endoscopy, RC648-665, medicine.disease, Radiation therapy, Rare Lesion, Female, case, Intermittent headache, Radiology, business
Abstract: In this article, we present a 31-year-old female who presented with intermittent headache and oligomenorrhea of over 10 years’ duration. Imaging revealed a large suprasellar mass with sellar extension. The patient underwent an endoscopic endonasal trans-sphenoidal surgery to resection of the mass. Clinical, radiological, and operative findings from this patient were initially considered to be Rathke’s cleft cyst (RCC). However, postoperative histological examinations revealed a mature cystic teratoma. No radiotherapy was performed after surgery. At the most recent follow-up, approximately 1 year later, the patient is doing well with no headache and no recurrence of the teratoma.
Published: 2021

140. Studies in the Area of Arachnoid Cysts Reported from Chicago (Pediatric intraspinal arachnoid cyst: successful endoscopic fenestration. Illustrative case).

Abstract: Keywords for this news article include: Division of Pediatric Neurosurgery, Chicago, Illinois, United States, North and Central America, Meninges, Pediatrics, Arachnoid Cysts, Health and Medicine, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Pediatrics EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Pediatrics 1163 1163 1 08/21/23 20230827 NES 230827 2023 AUG 27 (NewsRx) -- By a News Reporter-Staff News Editor at Medical Devices & Surgical Technology Week -- New study results on arachnoid cysts have been published. Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Pediatrics. [Extracted from the article]
Published: 2023

141. Selcuk University Reports Findings in Arachnoid Cysts (Intradural Spinal Arachnoid Cysts in Children: A Collective Experience of 2 Centers).

Subjects: ARACHNOID cysts, CENTRAL nervous system, NEUROLOGICAL disorders, CENTRAL nervous system diseases, CENTRAL nervous system tumors
Abstract: Keywords for this news article include: Konya, Turkey, Eurasia, Meninges, Pediatrics, Arachnoid Cysts, Health and Medicine, Congenital Abnormalities, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. Keywords: Konya; Turkey; Eurasia; Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Congenital Abnormalities; Health and Medicine; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Pediatrics EN Konya Turkey Eurasia Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Congenital Abnormalities Health and Medicine Meninges Nervous System Diseases and Conditions Nervous System Malformations Pediatrics 381 381 1 08/07/23 20230808 NES 230808 2023 AUG 12 (NewsRx) -- By a News Reporter-Staff News Editor at Pediatrics Week -- New research on Central Nervous System Diseases and Conditions - Arachnoid Cysts is the subject of a report. Konya, Turkey, Eurasia, Arachnoid Cysts, Arachnoid, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Congenital Abnormalities, Health and Medicine, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Pediatrics. [Extracted from the article]
Published: 2023

142. Data on Arachnoid Cysts Published by Researchers at Children's Hospital (Endoscopy-assisted purely total outer wall excision for pediatric Sylvian arachnoid cysts).

Abstract: Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Endoscopy, Health and Medicine, Meninges, Minimally Invasive Surgical Procedures, Nervous System Diseases and Conditions, Nervous System Malformations, Pediatrics, Surgery Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Endoscopy; Health and Medicine; Meninges; Minimally Invasive Surgical Procedures; Nervous System Diseases and Conditions; Nervous System Malformations; Pediatrics; Surgery EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Endoscopy Health and Medicine Meninges Minimally Invasive Surgical Procedures Nervous System Diseases and Conditions Nervous System Malformations Pediatrics Surgery 199 199 1 07/31/23 20230804 NES 230804 2023 AUG 6 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- Researchers detail new data in arachnoid cysts. [Extracted from the article]
Published: 2023

143. Acibadem University Researcher Adds New Study Findings to Research in Lower Back Pain (Treatment of symptomatic sacral arachnoid cysts in the pediatric population).

Abstract: Keywords: Arachnoid; Arachnoid Cysts; Back Pain; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Low Back Pain; Lower Back Pain; Meninges; Musculoskeletal Diseases and Conditions; Nervous System Diseases and Conditions; Nervous System Malformations; Neurologic Manifestations; Pain; Pediatrics; Surgery EN Arachnoid Arachnoid Cysts Back Pain Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Low Back Pain Lower Back Pain Meninges Musculoskeletal Diseases and Conditions Nervous System Diseases and Conditions Nervous System Malformations Neurologic Manifestations Pain Pediatrics Surgery 80 80 1 07/17/23 20230721 NES 230721 2023 JUL 23 (NewsRx) -- By a News Reporter-Staff News Editor at Pain & Central Nervous System Week -- New research on lower back pain is the subject of a new report. Arachnoid Cysts, Arachnoid, Back Pain, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Low Back Pain, Lower Back Pain, Meninges, Musculoskeletal Diseases and Conditions, Nervous System Diseases and Conditions, Nervous System Malformations, Neurologic Manifestations, Pain, Pediatrics, Surgery. [Extracted from the article]
Published: 2023

144. New Findings from Tsukuba Memorial Hospital in the Area of Arachnoid Cysts Published (Spontaneous resorption of a convexity arachnoid cyst associated with intracystic hemorrhage and subdural hematoma: A case report).

Subjects: ARACHNOID cysts, SUBDURAL hematoma, NEUROLOGICAL disorders, CENTRAL nervous system, HEMORRHAGE, CENTRAL nervous system diseases
Abstract: Arachnoid, Arachnoid Cysts, Central Nervous System, Central Nervous System Cysts, Central Nervous System Diseases and Conditions, Central Nervous System Neoplasms, Health and Medicine, Hemorrhage, Meninges, Nervous System Diseases and Conditions, Nervous System Malformations, Neuroimaging, Subdural Hematoma Keywords: Arachnoid; Arachnoid Cysts; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Health and Medicine; Hemorrhage; Meninges; Nervous System Diseases and Conditions; Nervous System Malformations; Neuroimaging; Subdural Hematoma EN Arachnoid Arachnoid Cysts Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Health and Medicine Hemorrhage Meninges Nervous System Diseases and Conditions Nervous System Malformations Neuroimaging Subdural Hematoma 492 492 1 07/17/23 20230717 NES 230717 2023 JUL 17 (NewsRx) -- By a News Reporter-Staff News Editor at Cardiovascular Week -- Current study results on arachnoid cysts have been published. Keywords for this news article include: Tsukuba Memorial Hospital, Tsukuba, Japan, Asia, Meninges, Hemorrhage, Neuroimaging, Arachnoid Cysts, Subdural Hematoma, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Central Nervous System Diseases and Conditions. [Extracted from the article]
Published: 2023

145. King Fahad Medical City Researcher Reports on Findings in Colloid Cysts (Extensive cerebral venous thrombosis after resection of third ventricle colloid cyst).

Subjects: BRAIN tumors, VENOUS thrombosis, CEREBRAL embolism & thrombosis, SINUS thrombosis, NEUROLOGICAL disorders, MEDICAL research personnel
Abstract: Keywords for this news article include: King Fahad Medical City, Riyadh, Saudi Arabia, Asia, Pain, Surgery, Headache, Hematology, Colloid Cysts, Venous Thrombosis, Health and Medicine, Embolism and Thrombosis, Neurologic Manifestations, Central Nervous System Cysts, Nervous System Malformations, Central Nervous System Neoplasms, Cardiovascular Diseases and Conditions, Nervous System Diseases and Conditions. Cardiovascular Diseases and Conditions, Central Nervous System Cysts, Central Nervous System Neoplasms, Colloid Cysts, Embolism and Thrombosis, Headache, Health and Medicine, Hematology, Nervous System Diseases and Conditions, Nervous System Malformations, Neurologic Manifestations, Pain, Surgery, Thrombosis, Vascular Diseases and Conditions, Venous Thrombosis Keywords: Cardiovascular Diseases and Conditions; Central Nervous System Cysts; Central Nervous System Neoplasms; Colloid Cysts; Embolism and Thrombosis; Headache; Health and Medicine; Hematology; Nervous System Diseases and Conditions; Nervous System Malformations; Neurologic Manifestations; Pain; Surgery; Thrombosis; Vascular Diseases and Conditions; Venous Thrombosis EN Cardiovascular Diseases and Conditions Central Nervous System Cysts Central Nervous System Neoplasms Colloid Cysts Embolism and Thrombosis Headache Health and Medicine Hematology Nervous System Diseases and Conditions Nervous System Malformations Neurologic Manifestations Pain Surgery Thrombosis Vascular Diseases and Conditions Venous Thrombosis 311 311 1 06/26/23 20230626 NES 230626 2023 JUN 26 (NewsRx) -- By a News Reporter-Staff News Editor at Hematology Week -- Investigators publish new report on colloid cysts. [Extracted from the article]
Published: 2023

146. Research Results from Technical University Munich (TU Munich) Update Understanding of Spinal Muscular Atrophy (Symptomatic intracranial hypertension in an adult patient with spinal muscular atrophy and arachnoid cysts receiving nusinersen).

Abstract: Keywords: Antisense Oligonucleotides; Arachnoid; Arachnoid Cysts; Brain Diseases and Conditions; Cardiovascular Diseases and Conditions; Central Nervous System; Central Nervous System Cysts; Central Nervous System Diseases and Conditions; Central Nervous System Neoplasms; Drugs and Therapies; Headache; Health and Medicine; Hypertension; Intracranial Hypertension; Meninges; Muscular Atrophy; Musculoskeletal Diseases and Conditions; Nervous System Diseases and Conditions; Nervous System Malformations; Neurologic Manifestations; Neuromuscular Diseases and Conditions; Nusinersen Therapy; Pain; Pharmaceuticals; Risk and Prevention; Spinal Muscular Atrophy EN Antisense Oligonucleotides Arachnoid Arachnoid Cysts Brain Diseases and Conditions Cardiovascular Diseases and Conditions Central Nervous System Central Nervous System Cysts Central Nervous System Diseases and Conditions Central Nervous System Neoplasms Drugs and Therapies Headache Health and Medicine Hypertension Intracranial Hypertension Meninges Muscular Atrophy Musculoskeletal Diseases and Conditions Nervous System Diseases and Conditions Nervous System Malformations Neurologic Manifestations Neuromuscular Diseases and Conditions Nusinersen Therapy Pain Pharmaceuticals Risk and Prevention Spinal Muscular Atrophy 898 898 1 06/12/23 20230616 NES 230616 2023 JUN 12 (NewsRx) -- By a News Reporter-Staff News Editor at Drug Week -- Data detailed on spinal muscular atrophy have been presented. [Extracted from the article]
Published: 2023

147. Phenotypic Variability in Leukoencephalopathy with Brain Calcifications and Cysts: Case Report of Siblings from an Irish Traveller Family with a Homozygous SNORD118 Mutation

Author: Michael Marnane, Sally Ann Lynch, and Patrick W Cullinane
Subjects: Adult, 0301 basic medicine, Pathology, medicine.medical_specialty, Aura, Population, Leukoencephalopathy, 03 medical and health sciences, Cellular and Molecular Neuroscience, Epilepsy, 0302 clinical medicine, Leukoencephalopathies, medicine, Humans, RNA, Small Nucleolar, Medical history, Central Nervous System Cysts, education, 3' Untranslated Regions, Exome sequencing, Genetic testing, education.field_of_study, medicine.diagnostic_test, business.industry, Homozygote, Calcinosis, General Medicine, medicine.disease, White Matter, Pedigree, 030104 developmental biology, Biological Variation, Population, Mutation, Female, Cerebral Cyst, business, 030217 neurology & neurosurgery
Abstract: Leukoencephalopathy with brain calcifications and cysts (LCC) is a rare cerebral microangiopathy, the cause of which was recently determined to be recessively inherited mutations in the SNORD118 gene. We report the case of a 32-year-old Irish Traveller woman who presented to the emergency department in convulsive status epilepticus with abnormal neuroimaging features characteristic of LCC. Her medical history consisted of epilepsy, intellectual impairment, previous craniotomies for excision of cerebral cysts and resection of a tibial osteogenic sarcoma. Whole exome sequencing identified a previously described homozygous variant, NR_033294.1 n.*5C>G, in the 3' UTR of the SNORD118 gene. Her sister was subsequently found to be homozygous for the same variant but with a significantly milder clinical phenotype consisting of migraine without aura and mild, non-specific, cerebral white matter changes on neuroimaging. Knowledge of the existence of LCC within this population means that targeted genetic testing for this specific mutation should be considered in Irish Traveller patients presenting with the characteristic clinical and radiological features. Given the striking phenotypic variability seen within this family, LCC should also be considered in Irish Traveller patients even in the absence of the complete radiological triad.
Published: 2020
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148. Rathke’s cleft cysts following transsphenoidal surgery: long-term outcomes and development of an optimal follow-up strategy

Author: Ziad Hussein, Stephanie E Baldeweg, Anouk Borg, Hani J. Marcus, Neil Dorward, Joan Grieve, and Zane Jaunmuktane
Subjects: Adult, Male, Reoperation, medicine.medical_specialty, Neoplasm, Residual, Adolescent, medicine.medical_treatment, Vision Disorders, Outcomes, Neurosurgical Procedures, New diagnosis, Young Adult, medicine, Long term outcomes, Humans, Cyst, In patient, Postoperative Period, Central Nervous System Cysts, Aged, Retrospective Studies, Cystic disease, Aged, 80 and over, Transsphenoidal surgery, Neurology & Neurosurgery, Brain Neoplasms, business.industry, Original Article - Pituitaries, Rathke’s cleft cyst, 1103 Clinical Sciences, Middle Aged, medicine.disease, Magnetic Resonance Imaging, Surgery, Treatment Outcome, Pituitary, Disease Progression, Female, Case note, Neurology (clinical), Neoplasm Recurrence, Local, Normal vision, 1109 Neurosciences, business, Follow-Up Studies
Abstract: Background In patients with symptomatic Rathke’s cleft cyst, transsphenoidal surgery is highly effective at preventing further visual loss and usually allows for some recovery of vision. However, cyst recurrence and the need for re-operation are well recognized. To this end, the aim of this study was to investigate patterns of recurrence and long-term outcomes and to use this information to develop an optimal follow-up strategy. Method A prospectively maintained database was searched over a 10-year period between 1 January 2008 and the 1 January 2018 to identify all adults that underwent transsphenoidal surgery with a new diagnosis of Rathke’s cleft cyst. A retrospective case note review was performed for each patient to extract data on their presentation, investigation, treatment, and outcome. Results In all, 61 eligible patients were identified. The median follow-up was 34 months (range 2–112 months). In the 22 patients with pre-operative visual loss, the outcomes at 6 months were as follows: normal vision (2/22; 9.1%), improved but not normal (7/22; 31.8%), stable (12/22; 54.5%), worse but not blind (1/22; 4.5%), and blind (0/22; 0%). The overall rate of regrowth and re-operation in our study was 19.7 and 11.5%, respectively. The only factor that was significantly associated with recurrence was the presence of residual cystic disease on the post-operative MRI (p Conclusions We propose a follow-up strategy that stratifies patients at “low risk” if there is no residual cyst, with increasing interval scans, or “high risk” if there is residual cyst, with annual visual assessment and scans.
Published: 2020
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149. Stereotactic Radiation as Salvage Therapy for Recurrent Rathke Cleft Cysts

Author: Matthew J. Koch, Navid Redjal, Marc R. Bussière, Brooke Swearingen, Trevor J. Royce, Jay S. Loeffler, and Pankaj K Agarwalla
Subjects: Male, medicine.medical_specialty, Drainage procedure, medicine.medical_treatment, Salvage therapy, Radiosurgery, Stereotactic radiotherapy, 03 medical and health sciences, 0302 clinical medicine, Refractory, Hypoadrenalism, medicine, Humans, Rathke Cleft Cysts, Central Nervous System Cysts, Aged, Retrospective Studies, Salvage Therapy, Brain Neoplasms, business.industry, Middle Aged, Radiation therapy, 030220 oncology & carcinogenesis, Drainage, Female, Surgery, Neurology (clinical), Radiology, Neoplasm Recurrence, Local, Headaches, medicine.symptom, business, 030217 neurology & neurosurgery
Abstract: Background Rathke cleft cysts (RCCs) are sellar-based cystic lesions that are often found incidentally but occasionally become symptomatic with significant visual and/or endocrine deficits. The standard of treatment is surgery, but rare cases of multiply recurrent RCCs can be refractory to surgical drainage, leading to significant morbidity. Objective To demonstrate the safety and feasibility of fractionated stereotactic radiotherapy (SRT) as salvage therapy in multiply recurrent RCCs refractory to surgical drainage. Methods An IRB-approved retrospective review at a single institution was conducted to identify and describe patients with multiply recurrent RCCs refractory to surgical drainage who underwent SRT. Results From 1994 to 2015, 6 patients (5 female) who underwent SRT for recurrent RCCs were identified. A total of 4 presented with visual deficits, and 2 presented with endocrine dysfunction and severe headaches prior to their initial drainage. All patients had initial postoperative improvement but then developed multiple, symptomatic recurrences. Median number of surgical drainage procedures prior to radiotherapy was 3. A total of 3 patients underwent LINAC-based SRT, and 3 had proton-based SRT. Treatment doses were 45 Gy over 25 fractions (n = 5) and 50.4 Gy over 28 fractions (n = 1). Median follow-up after radiation therapy was 69 mo (range 24-154 mo). In the follow-up period, stabilization of the RCC was achieved, although 2 patients required additional drainage procedures. Only 1 patient developed new hypothyroidism and hypoadrenalism after SRT. Conclusion In rare cases of multiply recurrent RCCs refractory to repeat surgical drainage, stereotactic fractionated radiation therapy is a safe and effective salvage therapy.
Published: 2020
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150. The neuroimaging features of Rathke's cleft cysts in children with endocrine-related diseases

Author: Serra Ozbal Gunes and Altan Gunes
Subjects: Male, Adolescent, Intraclass correlation, Contrast Media, Neuroimaging, Endocrine System Diseases, urologic and male genital diseases, 030218 nuclear medicine & medical imaging, 03 medical and health sciences, 0302 clinical medicine, medicine, Humans, Endocrine system, Pituitary Neoplasms, Radiology, Nuclear Medicine and imaging, Central Nervous System Cysts, Child, Pediatric Radiology, Retrospective Studies, medicine.diagnostic_test, business.industry, Ethics committee, Infant, Retrospective cohort study, Magnetic resonance imaging, Image Enhancement, medicine.disease, Magnetic Resonance Imaging, female genital diseases and pregnancy complications, Intensity (physics), Child, Preschool, Pituitary Gland, Diabetes insipidus, Female, Cardiology and Cardiovascular Medicine, business, Nuclear medicine, Follow-Up Studies
Abstract: PURPOSE: We aimed to evaluate the frequency and neuroimaging features of Rathke’s cleft cysts (RCCs) in children examined for endocrine-related diseases and to determine changes in the neuroimaging features of RCCs during the follow-up of children. We hypothesize that RCCs are being more commonly diagnosed in children with endocrine-related diseases and most of the RCCs show neither fluid intensity nor intensity due to high protein content on magnetic resonance imaging (MRI). METHODS: After approval by the local ethics committee, the medical records and contrast-enhanced pituitary MRI of 833 children (boys/girls, 338/495; mean age±SD, 9.4±3.7 years) were retrospectively reviewed between January 2016 and January 2019. The size, location, signal intensities, and postcontrast enhancement pattern of RCCs were assessed by a pediatric radiologist. Same imaging features were also independently reviewed by another radiologist to determine the interobserver agreement by using the kappa statistics (κ) and intraclass correlation coefficient (ICC). RESULTS: RCC was evident on MRI in 13.5% of the patients (boys/girls, 39/74; mean age±SD, 9.8±3.9 years). The mean size of RCCs was 5.5 mm (range, 3.1–8.5 mm). An RCC frequency higher than expected was found in patients with central precocious puberty, diabetes insipidus, and hypersecretion of prolactin (P = 0.007). The mean size of RCCs did not show significant differences among the clinical indications for MRI (P ≥ 0.461). All RCCs showed abnormal signal on T2-weighted image and most (89%) showed neither fluid intensity nor intensity due to high protein content (i.e., isointense on T1-weighted imaging and hypointense on T2-weighted imaging compared with the normal anterior pituitary gland). Eighty-four patients with RCCs (74%) had follow-up MRI and the mean follow-up was 1.5 years. In follow-ups, five RCCs disappeared; the mean size of 10 RCCs increased and that of 6 RCCs decreased. These size changes were not statistically significant (P = 0.376). No signal intensity changes of RCCs were seen during the follow-up, except for 4 RCCs, whose protein content increased over time and T1 signals increased on imaging. Interobserver agreements were almost perfect for the MRI findings of RCCs (κ and ICC range, 0.81–1, P < 0.001). CONCLUSION: RCCs were not uncommon in patients examined for endocrine-related diseases, and nearly 1 in 10 patients had an RCC. The size and signal intensities of RCCs may change over time and the evolution of RCCs is unpredictable. Most RCCs showed neither fluid intensity nor intensity due to high protein content on MRI, and all RCCs had an abnormal signal on T2-weighted imaging, thus eliminating the need to administer a contrast agent at follow-up imaging of the patients.
Published: 2020
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