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125. 11. Cardiac Resynchronization Therapy: Different Issues.

Author

Ammendola, E., Santangelo, L., Savarese, C., Cavallaro, C., D'Onofrio, A., and Calabrò, R.

Abstract

Objective Cardiac resynchronization therapy (CRT) using biventricular pacing has been a major advance in long-term therapy for treatment of congestive heart failure (CHF). Heart rate variability (HRV) analysis has become an important predictive tool in CHF for the effects arrhythmogenic. In our study we observed if CRT can affect HRV in patients with CHF after six months of follow-up. Methods and Results 20 consecutive patients with CHF (12 men and 8 women; mean age 64.9 ± 11.8, range 48-79 years, NYHA class III-IV, FE<35%, QRS>120 ms., intraventricular and interventricular delay) received biventricular pacing (Guidant Renewal 4). HRV recorded by implanted device and was performed at implantation and six months after procedure. After implantation QRS duration changed from 156 ± 21msec to 132 ± 16msec (p<0.001) and NYHA class decreased in all patients. Discussion Our data shows that CRT in CHF seems improve autonomic function and reduce adrenergic tone as demonstrate by increasing HRV. In conclusion biventricular pacing can exert a positive effect on the mechanism that sustains the harmful hyper-adrenergic state and so it could be useful in opposition to disease progression. [ABSTRACT FROM PUBLISHER]

Published
2005

126. Poster session Thursday 12 December - PM: 12/12/2013, 14:00-18:00 * Location: Poster area

Author

Garcia Martin, A, Fernandez Golfin, C, Salido Tahoces, L, Fernandez Santos, S, Jimenez Nacher, JJ, Moya Mur, JL, Velasco Valdazo, E, Hernandez Antolin, R, Zamorano Gomez, JL, Veronesi, F, Corsi, C, Caiani, EG, Lamberti, C, Tsang, W, Holmgren, C, Guo, X, Bateman, M, Iaizzo, P, Vannier, M, Lang, RM, Patel, AR, Adamayn, KG, Tumasyan, L R, Chilingaryan, AL, Nasr, G, Eleraki, A, Farouk, N, Axelsson, A, Langhoff, L, Jensen, MK, Vejlstrup, N, Iversen, K, Bundgaard, H, Watanabe, T, Iwai-Takano, M, Attenhofer Jost, C H, Pfyffer, M, Seifert, B, Scharf, C, Candinas, R, Medeiros-Domingo, A, Chin, J-Y, Yoon, HJ, Vollbon, W, Singbal, Y, Rhodes, K, Wahi, S, Katova, T M, Simova, I I, Hristova, K, Kostova, V, Pauncheva, B, Bircan, A, Sade, LE, Eroglu, S, Pirat, B, Okyay, K, Bal, U, Muderrisoglu, H, Heggemann, F, Buggisch, H, Welzel, G, Doesch, C, Hansmann, J, Schoenberg, S, Borggrefe, M, Wenz, F, Papavassiliu, T, Lohr, F, Roussin, I, Drakopoulou, M, Rosen, S, Sharma, R, Prasad, S, Lyon, AR, Carpenter, JP, Senior, R, Breithardt, O-A, Razavi, H, Arya, A, Nabutovsky, Y, Ryu, K, Gaspar, T, Kosiuk, J, Eitel, C, Hindricks, G, Piorkowski, C, Pires, S, Nunes, A, Cortez-Dias, N, Belo, A, Zimbarra Cabrita, I, Sousa, C, Pinto, F, Baron, T, Johansson, K, Flachskampf, FA, Christersson, C, Pires, S, Cortez-Dias, N, Nunes, A, Belo, A, Zimbarra Cabrita, I, Sousa, C, Pinto, F, Santoro, A, Federico Alvino, FA, Giovanni Antonelli, GA, Raffaella De Vito, RDV, Roberta Molle, RM, Sergio Mondillo, SM, Gustafsson, M, Alehagen, U, Johansson, P, Tsukishiro, Y, Onishi, T, Chimura, M, Yamada, S, Taniguchi, Y, Yasaka, Y, Kawai, H, Souza, J R M, Zacharias, L G T, Pithon, K R, Ozahata, T M, Cliquet, A JR, Blotta, M H, Nadruz, W JR, Fabiani, I, Conte, L, Cuono, C, Liga, R, Giannini, C, Barletta, V, Nardi, C, Delle Donne, MG, Palagi, C, Di Bello, V, Glaveckaite, S, Valeviciene, N, Palionis, D, Laucevicius, A, Hristova, K, Bogdanova, V, Ferferieva, V, Shiue, I, Castellon, X, Boles, U, Rakhit, R, Shiu, M F, Gilbert, T, Papachristidis, A, Henein, M Y, Westholm, C, Johnson, J, Jernberg, T, Winter, R, Ghosh Dastidar, A, Augustine, D, Cengarle, M, Mcalindon, E, Bucciarelli-Ducci, C, Nightingale, A, Onishi, T, Watanabe, T, Fujita, M, Mizukami, Y, Sakata, Y, Nakatani, S, Nanto, S, Uematsu, M, Saraste, A, Luotolahti, M, Varis, A, Vasankari, T, Tunturi, S, Taittonen, M, Rautakorpi, P, Airaksinen, J, Ukkonen, H, Knuuti, J, Boshchenko, A, Vrublevsky, A, Karpov, R, Yoshikawa, H, Suzuki, M, Hashimoto, G, Kusunose, Y, Otsuka, T, Nakamura, M, Sugi, K, Rosner, SJ, Orban, M, Lesevic, H, Karl, M, Hadamitzky, M, Sonne, C, Panaro, A, Martinez, F, Huguet, M, Moral, S, Palet, J, Oller, G, Cuso, I, Jornet, A, Rodriguez Palomares, J, Evangelista, A, Stoebe, S, Tarr, A, Pfeiffer, D, Hagendorff, A, Gilmanov, DSH, Baroni, MB, Cerone, EC, Galli, EG, Berti, SB, Glauber, MG, Soesanto, A, Yuniadi, Y, Mansyur, M, Kusmana, D, Venkateshvaran, A, Dash, P K, Sola, S, Govind, S C, Shahgaldi, K, Winter, R, Brodin, L A, Manouras, A, Dokainish, H, Sadreddini, M, Nieuwlaat, R, Lonn, E, Healey, J, Nguyen, V, Cimadevilla, C, Dreyfus, J, Codogno, I, Vahanian, A, Messika-Zeitoun, D, Lim, Y-J, Kawamura, A, Kawano, S, Polte, CL, Gao, S, Lagerstrand, KM, Cederbom, U, Bech-Hanssen, O, Baum, J, Beeres, F, Van Hall, S, Boering, YC, Zeus, T, Kehmeier, ES, Kelm, M, Balzer, JC, Della Mattia, A, Pinamonti, B, Abate, E, Nicolosi, GL, Proclemer, A, Bassetti, M, Luzzati, R, Sinagra, G, Hlubocka, Z, Jiratova, K, Dostalova, G, Hlubocky, J, Dohnalova, A, Linhart, A, Palecek, T, Sonne, C, Lesevic, H, Karl, M, Rosner, S, Hadamitzky, M, Ott, I, Malev, E, Reeva, S, Zemtsovsky, E, Igual Munoz, B, Alonso Fernandez Pau, PAF, Miro Palau Vicente, VMP, Maceira Gonzalez Alicia, AMG, Estornell Erill, JEE, Andres La Huerta, AALH, Donate Bertolin, LDB, Valera Martinez, FVM, Salvador Sanz Antonio, ASS, Montero Argudo Anastasio, AMA, Nemes, A, Kalapos, A, Domsik, P, Chadaide, S, Sepp, R, Forster, T, Onaindia, JJ, Arana, X, Cacicedo, A, Velasco, S, Rodriguez, I, Capelastegui, A, Sadaba, M, Gonzalez, J, Salcedo, A, Laraudogoitia, E, Archontakis, S, Gatzoulis, K, Vlasseros, I, Arsenos, P, Tsiachris, D, Vouliotis, A, Sideris, S, Karistinos, G, Kalikazaros, I, Stefanadis, C, Ancona, R, Comenale Pinto, S, Caso, P, Coppola, MG, Arenga, F, Cavallaro, C, Vecchione, F, Donofrio, A, Calabro, R, Correia, C E, Moreira, D, Cabral, C, Santos, JO, Cardoso, JS, Igual Munoz, B, Maceira Gonzalez, AMG, Estornell Erill Jordi, JEE, Jimenez Carreno, RJC, Arnau Vives, MAV, Monmeneu Menadas, JVMM, Domingo-Valero, DDV, Sanchez Fernandez, ESF, Montero Argudo Anastasio, AMA, Zorio Grima, EZG, Cincin, A, Tigen, K, Karaahmet, T, Dundar, C, Sunbul, M, Guler, A, Bulut, M, Basaran, Y, Mordi, I, Carrick, D, Berry, C, Tzemos, N, Cruz, I, Ferreira, A, Rocha Lopes, L, Joao, I, Almeida, AR, Fazendas, P, Cotrim, C, Pereira, H, Ochoa, J P, Fernandez, A, Filipuzzi, JM, Casabe, JH, Salmo, JF, Vaisbuj, F, Ganum, G, Di Nunzio, HJ, Veron, LF, Guevara, E, Salemi, VMC, Nerbass, FB, Portilho, N, Ferreira Filho, JCA, Pedrosa, RP, Arteaga-Fernandez, E, Mady, C, Drager, LF, Lorenzi-Filho, G, Marques, JS, Almeida, A M G, Menezes, M, Silva, GL, Placido, R, Amaro, C, Brito, D, Diogo, AN, Lourenco, M R, Azevedo, O, Moutinho, J, Nogueira, I, Machado, I, Portugues, J, Quelhas, I, Lourenco, A, Calore, C, Muraru, D, Melacini, P, Badano, LP, Mihaila, S, Puma, L, Peluso, D, Casablanca, S, Ortile, A, Iliceto, S, Kang, M-K, Yu, SH, Park, JJ, Kim, SH, Park, TY, Mun, H-S, C, S, Cho, S-R, Han, SW, Lee, N, Khalifa, E A, Hamodraka, E, Kallistratos, M, Zacharopoulou, I, Kouremenos, N, Mavropoulos, D, Tsoukas, A, Kontogiannis, N, Papanikolaou, N, Tsoukanas, K, Manolis, A, Villagraz Tecedor, L, Jimenez Lopez Guarch, C, Alonso Chaterina, S, Blazquez Arrollo, L, Lopez Melgar, B, Veitia Sarmiento, AL, Mayordomo Gomez, S, Escribano Subias, MP, Lichodziejewska, B, Kurnicka, K, Goliszek, S, Dzikowska Diduch, O, Kostrubiec, M, Krupa, M, Grudzka, K, Ciurzynski, M, Palczewski, P, Pruszczyk, P, Sakata, K, Ishiguro, M, Kimura, G, Uesugo, Y, Takemoto, K, Minamishima, T, Futuya, M, Matsue, S, Satoh, T, Yoshino, H, Signorello, MC, Gianturco, L, Colombo, C, Stella, D, Atzeni, F, Boccassini, L, Sarzi-Puttini, PC, Turiel, M, Kinova, E, Deliiska, B, Krivoshiev, S, Goudev, A, De Stefano, F, Santoro, C, Buonauro, A, Schiano-Lomoriello, V, Muscariello, R, De Palma, D, Galderisi, M, Ranganadha Babu, B, Chidambaram, SUNDAR, Sangareddi, V, Dhandapani, VE, Ravi, MS, Meenakshi, K, Muthukumar, D, Swaminathan, N, Ravishankar, G, Bruno, R M, Giardini, G, Catizzo, B, Brustia, R, Malacrida, S, Armenia, S, Cauchy, E, Pratali, L, Resamont2, Cesana, F, Alloni, M, Vallerio, P, De Chiara, B, Musca, F, Belli, O, Ricotta, R, Siena, S, Moreo, A, Giannattasio, C, Magnino, C, Omede, P, Avenatti, E, Presutti, D, Sabia, L, Moretti, C, Bucca, C, Gaita, F, Veglio, F, Milan, A, Eichhorn, JG, Springer, W, Helling, A, Alarajab, A, Loukanov, T, Ikeda, M, Kijima, Y, Akagi, T, Toh, N, Oe, H, Nakagawa, K, Tanabe, Y, Watanabe, N, Ito, H, Hascoet, S, Hadeed, K, Marchal, P, Bennadji, A, Peyre, M, Dulac, Y, Heitz, F, Alacoque, X, Chausseray, G, Acar, P, Kong, WILL, Ling, LH, Yip, JAMES, Poh, KK, Vassiliou, V, Rekhraj, S, Hoole, SP, Watkinson, O, Kydd, A, Boyd, J, Mcnab, D, Densem, C, Shapiro, LM, Rana, BS, Potpara, TS, Djikic, D, Polovina, M, Marcetic, Z, Peric, V, Lip, GYH, Gaudron, P, Niemann, M, Herrmann, S, Hu, K, Strotmann, J, Beer, M, Bijnens, B, Liu, D, Ertl, G, Weidemann, F, Peric, V, Jovanovic, A, Djikic, D, Otasevic, P, Kochanowski, J, Piatkowski, R, Scislo, P, Grabowski, M, Marchel, M, Opolski, G, Bandera, F, Guazzi, M, Arena, R, Corra, U, Ghio, S, Forfia, P, Rossi, A, Dini, F, Cahalin, LP, Temporelli, L, Rallidis, L, Tsangaris, I, Makavos, G, Anthi, A, Pappas, A, Orfanos, S, Lekakis, J, Anastasiou-Nana, M, Kuznetsov, V A, Krinochkin, D V, Yaroslavskaya, E I, Zaharova, E H, Pushkarev, G S, Mizia-Stec, K, Wita, K, Mizia, M, Loboz-Grudzien, K, Szwed, H, Kowalik, I, Kukulski, T, Gosciniak, P, Kasprzak, J, Plonska-Gosciniak, E, Cimino, S, Pedrizzetti, G, Tonti, G, Cicogna, F, Petronilli, V, De Luca, L, Iacoboni, C, Agati, L, Hoffmann, R, Barletta, G, Von Bardeleben, S, Kasprzak, J, Greis, C, Vanoverschelde, J, Becher, H, Galrinho, A, Moura Branco, L, Fiarresga, A, Cacela, D, Ramos, R, Cruz Ferreira, R, Van Den Oord, SCH, Akkus, Z, Bosch, JG, Renaud, G, Sijbrands, EJG, Verhagen, HJM, Van Der Lugt, A, Van Der Steen, AFW, Schinkel, AFL, Mordi, I, Tzemos, N, Stanton, T, Delgado, D, Yu, E, Drakopoulou, M, Gonzalez-Gonzalez, AM, Karonis, T, Roussin, I, Babu-Narayan, S, Swan, L, Senior, R, Li, W, Parisi, V, Pagano, G, Pellegrino, T, Femminella, GD, De Lucia, C, Formisano, R, Cuocolo, A, Perrone Filardi, P, Leosco, D, Rengo, G, Unlu, S, Farsalinos, K, Amelot, K, Daraban, A, Ciarka, A, Delcroix, M, Voigt, JU, Miskovic, A, Poerner, TD, Goebel, B, Stiller, CH, Moritz, A, Sakata, K, Uesugo, Y, Kimura, G, Ishiguro, M, Takemoto, K, Minamishima, T, Futuya, M, Satoh, T, Yoshino, H, Miyoshi, T, Tanaka, H, Kaneko, A, Matsumoto, K, Imanishi, J, Motoji, Y, Mochizuki, Y, Minami, H, Kawai, H, Hirata, K, Wutthimanop, A, See, O, Vathesathokit, P, Yamwong, S, Sritara, P, Rosner, A, Kildal, AB, Stenberg, TA, Myrmel, T, How, OJ, Capriolo, M, Frea, S, Giustetto, C, Scrocco, C, Benedetto, S, Grosso Marra, W, Morello, M, Gaita, F, Garcia-Gonzalez, P, Cozar-Santiago, P, Chacon-Hernandez, N, Ferrando-Beltran, M, Fabregat-Andres, O, De La Espriella-Juan, R, Fontane-Martinez, C, Jurado-Sanchez, R, Morell-Cabedo, S, Ridocci-Soriano, F, Mihaila, S, Piasentini, E, Muraru, D, Peluso, D, Casablanca, S, Puma, L, Naso, P, Iliceto, S, Vinereanu, D, Badano, LP, Tarzia, P, Villano, A, Figliozzi, S, Russo, G, Parrinello, R, Lamendola, P, Sestito, A, Lanza, GA, Crea, F, Sulemane, S, Panoulas, VF, Bratsas, A, Frankel, AH, Nihoyannopoulos, P, Dores, H, Andrade, MJ, Almeida, MS, Goncalves, PA, Branco, P, Gaspar, A, Gomes, A, Horta, E, Carvalho, MS, Mendes, M, Yue, WS, Li, XY, Chen, Y, Luo, Y, Gu, P, Yiu, KH, Siu, CW, Tse, HF, Cho, EJ, Lee, SH, Hwang, BH, Kim, DB, Jang, SW, Jeon, HK, Youn, HJ, and Kim, JH

Abstract

Background: Progress in the technique of TAVR requires good knowledge of the aortic root. With this aim new specialized software appears, with the ability of automated quantitative modeling of the AV and root from 3D TEE.The purpose of this study was to validate this model with the measurements made manually. Methods: Eight patients undergoing TAVR in our center where included. The diameters of the aortic annulus, sinotubular union (STU) and sinus of valsalva (SV) were measured by 2D TEE; diameters and areas of aortic annulus, STU and SV as well as anatomic aortic valve area were measured by 3D TEE. Afterwards, the images were analyzed using the new software (Figure 1). Results. We showed good correlation with aortic annulus diameter measured by 2D TEE (r:,832 p:,01) and excellent correlation with one of the aortic annulus diameter measured by 3D TEE (r:,941 p:,00). The same happened with the area (r:,720 p:,04). Regarding the measurements at SV level, the correlations between the diameters by 2D TEE and 3D TEE with the measurements obtained with the new model were the following (r:,771;p:,025) and (r:,797;p:,018). The correlation of the area was also good (r:,812 p:,014).An excellent correlation was found between the measurements at UST level. UST diameter by 2D TEE (r:,818;P:,013), by ETE3D (r:,800;p:,017) and area (r:,844;p:,008).Finally, the anatomic aortic valve area measured by the new model showed significant correlation with the 3D TTE (r:,830 p:,011). Conclusions. There is a proper correlation between manual and automated measurements analyzed by the new model. The feasibility of determine the TAVR results with geometric models based on image, prior to procedure, is one of the possibilities of this new software. Prospective studies are necessary to define its applicability. Figure 1

Published
2013
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130. A Novel Spatial-Temporal Analysis Approach to Pedestrian Groups Detection

Author

Claudia Cavallaro, Giuseppe Vizzari, Cristani, M, Toro, C, Zanni-Merk, C, Howlett, RJ, Jain, LC, Cavallaro, C, and Vizzari, G

Subjects
Groups, Analysis of pedestrian trajectorie, General Earth and Planetary Sciences, INF/01 - INFORMATICA, Group, Analysis of pedestrian trajectories, Clustering, General Environmental Science
Abstract

The growing availability of geo-referred data describing human behaviour, at different scales and levels of granularity, represents an opportunity for the development and application of data analysis algorithms, whose usage can range from security, to traffic, to architectural design and planning, and even marketing. Focusing on pedestrian generated trajectories, the presence of groups within an analyzed population can influence overall dynamics, from microscopic perspective, and it can provide significant indications. Several approaches for video footage analyses are available, but they generally focus on microscopic features of videos and trajectories and they are generally not suited to scale to the analysis of relatively large datasets of trajectories. The present work proposes a novel approach to spatial-temporal analysis of pedestrian trajectories aimed at detecting groups of pedestrians within large datasets and having minimal assumptions on the nature of these groups.

Published
2022

131. A focus on selected perspectives of the NUMEN project

Author

Cavallaro M., Agodi C., Bellone J. I., Brasolin S., Brischetto G. A., Bussa M. P., Calabrese S., Calvo D., Campajola L., Capirossi V., Cappuzzello F., Carbone D., Ciraldo I., Colonna M., De Benedictis C., De Gregorio G., Delaunay F., Dumitrache F., Ferraresi C., Finocchiaro P., Fisichella M., Gallian S., Gambacurta D., Gandolfo E. M., Gargano A., Giovannini M., Iazzi F., Lanzalone G., Lavagno A., Mereu P., Neri L., Pandola L., Panero R., Persiani R., Pinna F., Russo A. D., Russo G., Santopinto E., Sartirana D., Sgouros O., Sharma V. R., Soukeras V., Spatafora A., Torresi D., Tudisco S., Avanzi L. H., Cardozo E. N., Chinaglia E. F., Costa K. M., Ferreira J. L., Linares R., Lubian J., Masunaga S. H., Medina N. H., Moralles M., Oliveira J. R. B., Santarelli T. M., Santos R. B. B., Guazzelli M. A., Zagatto V. A. B., Koulouris S., Pakou A., Souliotis G., Acosta L., Amador-Valenzuela P., Bijker R., Chavez Lomeli E. R., Garcia-Tecocoatzi H., Huerta Hernandez A., Marin-Lambarri D. J., Vargas Hernandez H., Villagran R. G., Boztosun I., Dapo H., Eke C., Firat S., Hacisalihoglu A., Kucuk Y., Solakci S. O., Yildirim A., Auerbach N., Burrello S., Lenske H., Isaak J., Pietralla N., Werner V., Lay J. A., Petrascu H., Ferretti J., Kotila J., Donaldson L. M., Khumalo T., Neveling R., Pellegri L., Guazzelli, Marcilei Aparecida, Alves Carvalho, Carla Regina, Malheiro, Manuel, Medina, Nilberto Heder, M. Cavallaro, C. Agodi, J.I. Bellone, S. Brasolin, G.A. Brischetto, M.P. Bussa, S. Calabrese, D. Calvo, L. Campajola, V. Capirossi, F. Cappuzzello, D. Carbone, I. Ciraldo, M. Colonna, C. De Benedictis, G. De Gregorio, F. Delaunay, F. Dumitrache, C. Ferraresi, P. Finocchiaro, M. Fisichella, S. Gallian, D. Gambacurta, E.M. Gandolfo, A. Gargano, M. Giovannini, F. Iazzi, G. Lanzalone, A. Lavagno, P. Mereu, L. Neri, L. Pandola, R. Panero, R. Persiani, F. Pinna, A.D. Russo, G. Russo, E. Santopinto, D. Sartirana, O. Sgouros, V.R. Sharma, V. Soukeras, A. Spatafora, D. Torresi, S. Tudisco, L.H. Avanzi, E.N. Cardozo, E.F. Chinaglia, K.M. Costa, J.L. Ferreira, R. Linares, J. Lubian, S. H. Masunaga, N.H. Medina, M. Moralles, J.R.B. Oliveira, T.M. Santarelli, R.B.B. Santos, M.A. Guazzelli, V.A.B. Zagatto, S. Koulouris, A. Pakou, G. Souliotis, L. Acosta, P. Amador-Valenzuela, R. Bijker, E.R. Chávez Lomelí, H. Garcia-Tecocoatzi, A. Huerta Hernandez, D.J. Marín-Lámbarri, H. Vargas Hernandez, R. G. Villagrán, I. Boztosun, H. Dapo, C. Eke, S. Firat, A. Hacisalihoglu, Y. Kucuk, S.O. Solakcı, A. Yildirim, N. Auerbach, S. Burrello, H. Lenske, J. Isaak, N. Pietralla, V. Werner, J.A. Lay, H. Petrascu, J. Ferretti, J. Kotila, L. M. Donaldson, T. Khumalo, R. Neveling, L. Pellegri, Cavallaro, M., Agodi, C., Bellone, J. I., Brasolin, S., Brischetto, G. A., Bussa, M. P., Calabrese, S., Calvo, D., Campajola, L., Capirossi, V., Cappuzzello, F., Carbone, D., Ciraldo, I., Colonna, M., De Benedictis, C., De Gregorio, G., Delaunay, F., Dumitrache, F., Ferraresi, C., Finocchiaro, P., Fisichella, M., Gallian, S., Gambacurta, D., Gandolfo, E. M., Gargano, A., Giovannini, M., Iazzi, F., Lanzalone, G., Lavagno, A., Mereu, P., Neri, L., Pandola, L., Panero, R., Persiani, R., Pinna, F., Russo, A. D., Russo, G., Santopinto, E., Sartirana, D., Sgouros, O., Sharma, V. R., Soukeras, V., Spatafora, A., Torresi, D., Tudisco, S., Avanzi, L. H., Cardozo, E. N., Chinaglia, E. F., Costa, K. M., Ferreira, J. L., Linares, R., Lubian, J., Masunaga, S. H., Medina, N. H., Moralles, M., Oliveira, J. R. B., Santarelli, T. M., Santos, R. B. B., Guazzelli, M. A., Zagatto, V. A. B., Koulouris, S., Pakou, A., Souliotis, G., Acosta, L., Amador-Valenzuela, P., Bijker, R., Chavez Lomeli, E. R., Garcia-Tecocoatzi, H., Huerta Hernandez, A., Marin-Lambarri, D. J., Vargas Hernandez, H., Villagran, R. G., Boztosun, I., Dapo, H., Eke, C., Firat, S., Hacisalihoglu, A., Kucuk, Y., Solakci, S. O., Yildirim, A., Auerbach, N., Burrello, S., Lenske, H., Isaak, J., Pietralla, N., Werner, V., Lay, J. A., Petrascu, H., Ferretti, J., Kotila, J., Donaldson, L. M., Khumalo, T., Neveling, R., and Pellegri, L.

Subjects
History, ydinreaktiot, ilmaisimet, tutkimuslaitteet, ydinfysiikka, Computer Science Applications, Education
Abstract

The use of double charge exchange reactions is discussed in view of their application to extract information that may be helpful to determinate the nuclear matrix elements entering in the expression of neutrinoless double beta decay half-life. The strategy adopted in the experimental campaigns performed at INFN - Laboratori Nazionali del Sud and in the analysis methods within the NUMEN project is briefly described, emphasizing the advantages of the multi-channel approach to nuclear reaction data analysis. An overview on the research and development activities on the MAGNEX magnetic spectrometer is also given, with a focus on the chosen technological solutions for the focal plane detector which will guarantee the performances at high-rate conditions.

Published
2022

132. Pressure–volume relationship by pharmacological stress cardiovascular magnetic resonance

Author

Giuseppina Novo, Chrysanthos Grigoratos, Gianfranco Sinagra, Michele Emdin, Giancarlo Todiere, Francesco Grigioni, Chiara Cappelletto, A Pepe, Cinzia Nugara, Valeria Calvi, Antonella Meloni, Maria Vaccaro, Antonio De Luca, Camilla Cavallaro, Andrea Barison, Meloni A., De Luca A., Nugara C., Vaccaro M., Cavallaro C., Cappelletto C., Barison A., Todiere G., Grigoratos C., Calvi V., Novo G., Grigioni F., Emdin M., Sinagra G., and Pepe A.

Subjects
Cardiovascular magnetic resonance imaging, Reproducibility, medicine.medical_specialty, Dipyridamole, End-systolic pressure–volume relation, Myocardial contractility, Ejection fraction, medicine.diagnostic_test, business.industry, Magnetic resonance imaging, medicine.disease, Contractility, Coronary artery disease, Internal medicine, Cardiology, Stress Echocardiography, Medicine, Radiology, Nuclear Medicine and imaging, Cardiology and Cardiovascular Medicine, business, Cardiac imaging, medicine.drug
Abstract

Background. The variation between rest and peak stress end-systolic pressure-volume relation (ΔESPVR) is an index of myocardial contractility, easily obtained during routine stress echocardiography and never tested during dipyridamole stress-cardiac magnetic resonance (CMR). We assessed the ΔESPVR index in patients with known/suspected coronary artery disease (CAD) who underwent dipyridamole stress-CMR.Methods. One-hundred consecutive patients (24 females, 63.76±10.17 years) were considered. ESPVR index was evaluated at rest and stress from raw measurement of systolic arterial pressure and end-systolic volume by biplane Simpson’s method. Results. The ΔESPVR index showed a good inter-operator reproducibility. Mean ΔESPVR index was 0.48±1.45 mmHg/mL/m2. ΔESPVR index was significantly lower in males than in females. ΔESPVR index was not correlated to rest left ventricular end-diastolic volume index or ejection fraction. Forty-six of 85 patients had myocardial fibrosis detected by the late gadolinium enhancement technique and they showed significantly lower ΔESPVR values. An abnormal stress CMR was found in 25 patients and they showed significantly lower ΔESPVR values. During a mean follow-up of 56.34±30.04 months, 24 cardiovascular events occurred. At receiver-operating characteristic curve analysis, a ΔESPVRConclusions. The noninvasive assessment of the ΔESPVR index during a dipyridamole stress-CMR exam is feasible and reproducible. The ΔESPVR index was independent from rest LV dimensions and function and can be used for a comparative assessment of patients with different diseases. ΔESPVR by CMR can be a useful and simple marker for additional prognostic stratification.

Published
2021

133. Noterelle di conferma sull'interesse legittimo

Author

GUIDO CLEMENTE DI SAN LUCA, C. Acocella, G. Acocella, S. Amorosino, F.G. Angelini, S. Antoniazzi, M. Antonioli, A. Areddu, G. Armao, F. Armenante, F. Astone, A. Barone, A. Bartolini, A. Benedetti, C. Benetazzo, V. Berlingò, E. Boscolo, C. Bottari, F. Laus, C. Cacciavillani, M. Cafagno, M. Calabrò, V. Caputi Jambrenghi, A. Angiuli, A. Caracciolo La Grotteria, E. Caracciolo La Grotteria, E. Cardi, E. Carloni, G.F. Cartei, G. Carullo, A. Cassatella, A. Catelani, M.C. Cavallaro, C. Celone, G. Chiara, P. Chirulli, M.P. Chiti, F. Cimbali, S. Cimini, F. Cintioli, A. Cioffi, M. Clarich, G. Clemente di San Luca, M. Cocconi, G. Cocozza, S. Cognetti, A. Colavecchio, G. Colombini, G.D. Comporti, A. Contieri, G. Corso, F. Costantino, G. Crepaldi, A. Crismani, A. Crosetti, C. Cudia, C. Cupelli, F. D'Angelo, M. D'Angelosante, S. D'Antonio, M. D'Arienzo, G. D'Emma, D. D'Orsogna, M. D'Orsogna, D. De Carolis, M. De Cristofaro, M. De Donno, G. De Giorgi Cezzi, F. de Leonardis, G. De Maio, E. De Marco, G.C. De Martin, R. De Nictolis, A. De Siano, G. della Cananea, M.G. Della Scala, M. Delsignore, S. Dettori, A. Di Giovanni, M. Dipace, R. Dipace, V. Domenichelli, M. Dugato, V. Fanti, C. Feliziani, L. Ferrara, M.V. Ferroni, F. Figorilli, W. Giulietti, O. Fiumara, E. Follieri, P. Forte, M. Fracanzani, F. Fracchia, F. Francario, F. Gaffuri, D.U. Galetta, C.E. Gallo, F. Gallo, F. Gambardella, G. Gargano, F. Gaspari, V. Gasparini Cesari, W. Gasparri, M.P. Genesin, L. Giani, E. Giardino, F. Giglioni, V. Giomi, A. Giusti, M. Gola, G. Greco, P. Grossi, C. Guacci, N. Gullo, G. Guzzardo, A. Iacopino, G. Iacovone, M. Immordino, I. Impastato, M. Interlandi, M. Ippolito, L. Lamberti, S. Lariccia, A. Lazzaro, G. Leone, G.F. Licata, S. Licciardello, F. Liguori, P. Lombardi, R. Lombardi, N. Longobardi, F. Lubrano, S. Lucattini, M. Luciani, A. Lupo, L. Maccarrone, M. Macchia, A. Maltoni, B. Mameli, F. Manganaro, V. Manzetti, F. Marinelli, D. Marongiu, D. Marrama, G. Martini, A. Massera, A. Masucci, M. Mazzamuto, F. Merusi, S. Mirate, V. Molaschi, G. Morbidelli, L. Murgolo, C.M.A. Orrei, G. Pagliari, C. Pagliarin, G. Palma, M. Palma, G. Palmieri, N. Paolantonio, P. Patrito, S. Pellizzari, L.R. Perfetti, S. Perongini, E. Picozza, G. Piperata, A. Police, P.L. Portaluri, G.A. Primerano, A. Proto Pisani, M. Protto, P. Provenzano, A. Pubusa, F. Pubusa, S. Puddu, M. Ragusa, M. Ramajoli, M. Renna, R. Rolli, E. Romano, M.C. Romano, A. Romeo, G. Rossi, F. Saitta, N. Saitta, F. Salvia, L. Sambucci, A. Sandulli, M.A. Sandulli, F. Satta, E.F. Schlitzer, D. Siclari, A. Simonati, H. Simonetti, B. Sordi, G. Sorrentino, R. Spagnuolo Vigorita, B. Spampinato, M.R. Spasiano, P. Stella Richter, P. Tanda, S. Tarullo, A. Tigano, F. Tigano, M. Timo, R. Titomanlio, M. Trimarchi, W. Troise Mangoni, G. Tropea, A. Giannelli, F.F. Tuccari, S. Tuccillo, G. Urbano, R. Ursi, S. Vasta, G. Vercillo, G. Vesperini, F. Vetrò, N. Vettori, C. Videtta, S. Villamena, R. Villata, P.M. Vipiana, F. Zammartino, A. Zito, and CLEMENTE DI SAN LUCA, Guido

Published
2020

134. Efficiency Enhancement of Permanent-Magnet Synchronous Motor Drives by Online Loss Minimization Approaches

Author

Rosario Miceli, Marco Trapanese, Angelo Raciti, A. O. Di Tommaso, C. Cavallaro, Giuseppe Ricco Galluzzo, CAVALLARO, C, DI TOMMASO, AO, MICELI, R, RACITI, A, RICCO GALLUZZO, G, and TRAPANESE, M

Subjects
Permanent magnet synchronous motor, Control and Systems Engineering, Computer science, Control theory, Control engineering, Loss minimization, Electrical and Electronic Engineering, Synchronous motor, Machine control
Abstract

In this paper, a new loss minimization control algorithm for inverter-fed permanent-magnet synchronous motors (PMSMs), which allows for the reduction of the power losses of the electric drive without penalty on its dynamic performance, is analyzed, experimentally realized, and validated. In particular, after a brief recounting of two loss minimization control strategies, namely, the "search control" and the "loss-model control," both a new modified dynamic model of the PMSM (which takes into account the iron losses) and an innovative "loss-model" control strategy are presented. Experimental tests on a specific PMSM drive employing the proposed loss minimization algorithm have been performed, aiming to validate the actual implementation. The main results of these tests confirm that the dynamic performance of the drive is maintained, and in small motors enhancement up to 3.5% of the efficiency can be reached in comparison with the PMSM drive equipped with a more traditional control strategy.

Published
2005

135. Automotive Brushless Motor Powered by Fuel Cell

Author

Angelo Raciti, C. Cavallaro, R. Liga, Rosario Miceli, Valeria Boscaino, Boscaino,V, Liga, R, Miceli,R, Cavallaro, C, and Raciti, A

Subjects
Brushless motors, Computer science, business.industry, Automotive industry, Fuel cells, Control engineering, AC motor drives, Brushless motor, automotive, simulation, fuel cell, Settore ING-IND/32 - Convertitori, Macchine E Azionamenti Elettrici, business, AC motor, Automotive engineering
Published
2014

136. Coronary sinus spasm during left ventricular lead implantation for biventricular pacing

Author

Vincenzo Russo, Ilaria De Crescenzo, Raffaele Calabrò, Lucio Santangelo, Ciro Cavallaro, Ernesto Ammendola, Russo, V, DE CRESCENZO, I, Ammendola, E, Cavallaro, C, Santangelo, Lucio, and Calabrò, R.

Subjects
Male, Pacemaker, Artificial, medicine.medical_specialty, Ventricular lead, business.industry, Contrast Media, Coronary Vasospasm, Middle Aged, Coronary Angiography, Electrodes, Implanted, Electrocardiography, Fluoroscopy, Physiology (medical), Internal medicine, Infusion Procedure, otorhinolaryngologic diseases, cardiovascular system, medicine, Cardiology, Humans, cardiovascular diseases, Cardiology and Cardiovascular Medicine, business, Coronary sinus, circulatory and respiratory physiology
Abstract

The authors present a case of coronary sinus spasm during left ventricular lead implantation for biventricular pacing relieved by direct infusion of nitroglycerin.

Published
2007

137. Endocervicoscopy: a new technique for the diagnostic work-up of cervical intraepithelial neoplasia allowing a tailored excisional therapy in young fertile women

Author

Angelo Cavallaro, Roberto Piccoli, Carmine Nappi, Giuseppe Bifulco, Marialuigia Spinelli, Giada Lavitola, Attilio Di Spiezio Sardo, G. Bifulco, R. Piccoli, G. Lavitola, A. Di Spiezio Sardo, M. Spinelli, A. Cavallaro, C. Nappi, Bifulco, Giuseppe, Piccoli, R., Lavitola, Giada, DI SPIEZIO SARDO, Attilio, Spinelli, M., Cavallaro, A., Nappi, Carmine, Piccoli, Roberto, Spinelli, M, and Cavallaro, A

Subjects
Adult, medicine.medical_specialty, Time Factors, medicine.medical_treatment, Biopsy, Uterine Cervical Neoplasms, Cervix Uteri, Hysteroscopy, Cervical intraepithelial neoplasia, Sensitivity and Specificity, Young Adult, Gynecologic Surgical Procedures, Predictive Value of Tests, medicine, Humans, Colposcopy, medicine.diagnostic_test, business.industry, Obstetrics and Gynecology, medicine.disease, Cervical conization, Uterine Cervical Dysplasia, Curettage, Surgery, Radiography, Squamous intraepithelial lesion, Fertility, Reproductive Medicine, Predictive value of tests, Female, business
Abstract

Objective To propose and validate endocervicoscopy, a new technique for patients with high-grade squamous intraepithelial lesion and unsatisfactory or negative colposcopy. Design Prospective trial. Setting Department of Obstetrics, Gynaecology and Pathophysiology of Human Reproduction University of Naples Federico II. Patient(s) Ninety-five consecutive patients with repeatedly positive cervicovaginal cytology for high-grade squamous intraepithelial lesion and negative or unsatisfactory colposcopy. Intervention(s) Endoscopic evaluation of the endocervical mucosa, performed with an office continuous-flow hysteroscope after application of acetic acid 5% (endocervicoscopy). Patients diagnosed with abnormal cervical findings (group A) underwent targeted biopsies of the visualized abnormalities. Negative patients at endocervicoscopy (group B) underwent blind curettage of the endocervix. Eventually, both groups underwent a cold knife conization. Main Outcome Measure(s) Sensitivity, specificity, accuracy, positive predictive value (PPV), and negative predictive value (NPV) of endocervicoscopy plus targeted biopsy and curettage, compared with the reference test, represented by surgical specimen of cervical conization. Result(s) Endocervicoscopy plus targeted biopsy showed a sensitivity of 79%, a specificity of 100%, a diagnostic accuracy of 80%, a PPV of 99%, and a NPV of 51%. The volume of cone biopsy of patients from group A was significantly smaller than that of group B (3.03 ± 0.61 mL vs. group B: 4.07 ± 0.24 mL). Conclusion(s) Endocervicoscopy appears to be a safe and effective office technique, improving the diagnostic work-up of cervical intraepithelial lesions. The precise localization of the lesions allows for the depth of cone excision to be tailored, thus leading to a more conservative treatment and preserving the future fertility of women.

Published
2009

138. Influence of biventricular pacing on myocardial dispersion of repolarization in dilated cardiomyopathy patients

Author

Lucio Santangelo, Salvatore Garofalo, Vincenzo Russo, Raffaele Calabrò, Ciro Cavallaro, Antonio D'Onofrio, Filippo Vecchione, Ernesto Ammendola, Santangelo, Lucio, Ammendola, E, Russo, V, Cavallaro, C, Vecchione, F, Garofalo, S, D'Onofrio, A, and Calabro', Raffaele

Subjects
Cardiomyopathy, Dilated, Male, medicine.medical_specialty, Heart Ventricles, Diastole, Mean QRS Duration, Heart failure, QRS complex, Electrocardiography, Physiology (medical), Internal medicine, Medicine, Repolarization, Humans, Sinus rhythm, cardiovascular diseases, Heart Failure, JT dispersion, Analysis of Variance, Ejection fraction, business.industry, Cardiac Pacing, Artificial, Dilated cardiomyopathy, Middle Aged, medicine.disease, Treatment Outcome, Transmural dispersion of repolarization, Biventricular pacing, cardiovascular system, Cardiology, QT dispersion, Female, Cardiology and Cardiovascular Medicine, business
Abstract

Aims The aim of our study was to evaluate the effect of cardiac resyncronization therapy on QT dispersion (QTd), JT dispersion (JTd), and transmural dispersion of repolarization (TDR), markers of heterogeneity of ventricular repolarization in a study population with severe heart failure. Methods and results Fifty patients (43 male, 7 female, age 60.2+3.1 years) suffering from congestive heart failure (n ¼ 39 NYHA class III; n ¼ 11 NYHA class IV) as a result of coronary artery disease (n ¼ 19)or of dilated cardiomyopathy (n ¼ 31), with sinus rhythm (SR), QRS duration .120 ms (mean QRS duration ¼ 156+21 ms), an ejection fraction ,35%, left ventricular end-diastolic diameter .55 mm, presence of atrioventricular asynchrony, intra- and inter-ventricular asynchrony, underwent permanent biventricular pacemaker implantation. A 12-lead standard electrocardiogram was performed at baseline, during right-, left-, and biventricular pacing (BiVP) and QTd, JTd, and TDR were assessed. BiVP significantly reduced QTd (73.93+19.4 ms during BiVP vs. 91+6.7 ms in SR, P ¼ 0.004), JTd (73.18+17.16 ms during BiVP vs. 100.72+39.04 at baseline, P ¼ 0.003), TDR (93.16+15.60 vs.101.55+19.08 at baseline, P , 0.004), compared with SR. Right ventricular endocardial pacing and left ventricular epicardial pacing both increased QTd (RVendoP 94+51 ms, P , 0.03; LVepiP 116+71 ms, P , 0.02), and TDR (RVendoP 108.13+19.94 ms, P , 0.002; LVepiP 114.71+26.1, P , 0.05). There was no effect on JTd during right and left ventricular stimulation. Conclusions BiVP causes a statistically significant reduction of ventricular heterogeneity of repolarization and has an electrophysiological anti-arrhythmic influence on the arrhythmogenic substrate of dilated cardiomyopathy.

Published
2006

139. Test cycles for the characterization of electrical drives devoted to wheelchair applications

Author

Angelo Raciti, V. Di Dio, A. O. Di Tommaso, C. Cavallaro, Rosario Miceli, Di Dio V., Di Tommaso A.O., Miceli R., Cavallaro C., and Raciti A.

Subjects
Engineering, business.industry, Disabled people, Wheelchair, Settore ING-IND/32 - Convertitori, Macchine E Azionamenti Elettrici, Automotive engineering, Field (computer science), Electrical drives, Test (assessment), Characterization (materials science), business, Test cycles, Simulation
Abstract

Today electrical wheelchairs are giving valuable increase of the quality of life of disabled people in developed countries. Despite the increasing diffusion of such an aid tool, specific standards for the characterization of their electric drives are not so developed as those available for urban electric vehicles. This paper presents a proposal for the test characterization of a wheelchair drive by means of test cycles with fixed speed trajectories. To this aim, the method, which is well known in the field of automobiles, has been purposely adapted and the obtained simulation results are satisfactory.

Published
2003

140. Analysis a DSP Implementation and Experimental Validation of a Loss Minimization Algorithm Applied to Permanent Magnet Synchronous Motor Drives

Author

A. O. Di Tommaso, G. Ricco Galluzzo, Marco Trapanese, Angelo Raciti, Rosario Miceli, C. Cavallaro, Cavallaro C., Di Tommaso A.O., Miceli R., Raciti A., Ricco Galluzzo G., and Trapanese M.

Subjects
Control systems, Permanent magnet synchronous motor, Computer science, business.industry, Experimental validation, Settore ING-IND/32 - Convertitori, Macchine E Azionamenti Elettrici, Control theory, Efficiency improvement, Motor drives, Loss minimization, Variable speed drives, business, Synchronous motor, Algorithm, Digital signal processing
Abstract

In this paper a new loss minimization control algorithm for inverter-fed permanent-magnet synchronous motors (PMSM), which allows to reduce the power losses of the electric drive without penalty on its dynamic performances, is analyzed, experimentally realized and validated. In particular, after a brief recall of two loss minimization control strategies (the "search control" and the "loss-model control"), both a modified dynamic model of the PMSM, which takes into account the iron losses, and a "loss-model" control strategy, are treated. Experimental tests on a specific PMSM drive employing the proposed loss minimization algorithm were performed aiming to validate the actual implementation. The main results of these tests confirm that the dynamic performances of the drive are maintained, and enhancement up to 3.5% of the efficiency can be reached in comparison to the PMSM drive equipped with a more traditional control strategy.

Published
2003

141. Efficiency Improvement of Inverter-Fed Permanent Magnet Synchronous Motors

Author

C. Cavallaro, G. Ricco Galluzzo, A. O. Di Tommaso, Marco Trapanese, Angelo Raciti, Rosario Miceli, Cavallaro, C, Di Tommaso, A. O., Miceli, R., Raciti, A., Ricco Galluzzo, G., and Trapanese, M.

Subjects
Reduction (complexity), Power loss, Control algorithm, Permanent magnet synchronous motor, Control theory, Computer science, Inverter, Loss minimization, Load torque, Settore ING-IND/32 - Convertitori, Macchine E Azionamenti Elettrici, Electrical drives
Abstract

In this paper a control algorithm for the efficiency improvement of inverter-fed permanent magnet synchronous motors (PMSMs) is presented. The proposed algorithm allows reducing the losses of the drive without reduction of its dynamic performances. In details, after recalling a dynamic model of the PMSM, which has been purposely modified and that takes into account the iron losses, the basic equations and the constraints to obtain the loss minimization are presented and discussed. Some simulations of a specific PMSM drive employing the proposed algorithm are performed. The results of these simulations show that the dynamic performances are maintained, and enhancement of the efficiency up to 5% can be reached in comparison to a PMSM drive using a more traditional control strategy.

Published
2003

142. Assessment of accessory atrioventricular pathways by Doppler myocardial imaging

Author

Antonello D'Andrea, Alfonso Roberto Martiniello, Carmine Musto, F.E.S.C. Pio Caso M.D., Filippo Vecchione, Nicola Mininni, Ciro Cavallaro, Raffaele Calabrò, F.E.S.C. George R. Sutherland M.D., Stefano Nardi, Caso, P, D'Andrea, A, Musto, C, Nardi, S, Cavallaro, C, Martiniello, Ar, Vecchione, F, Mininni, N, Calabro', Raffaele, and Sutherland, Gr

Subjects
Adult, Male, Pathology, medicine.medical_specialty, Radiofrequency ablation, Accessory Atrioventricular Pathways, Sensitivity and Specificity, Severity of Illness Index, Ventricular Function, Left, law.invention, symbols.namesake, Electrocardiography, law, Heart Conduction System, Reference Values, Internal medicine, Preoperative Care, Medicine, Humans, Radiology, Nuclear Medicine and imaging, Postoperative Period, Prospective Studies, Echocardiography, Doppler, Pulsed, business.industry, Ultrasound, Depolarization, Gold standard (test), Middle Aged, Myocardial imaging, Prognosis, Ventricular Premature Complexes, Echocardiography, Doppler, Color, Electrophysiology, Treatment Outcome, Case-Control Studies, Ventricular preexcitation, Cardiology, symbols, Catheter Ablation, Female, Wolff-Parkinson-White Syndrome, Cardiology and Cardiovascular Medicine, business, human activities, Doppler effect
Abstract

Purpose: The use of electrophysiologic studies (EPS) for the localization of accessory atrioventricular connections in Wolff-Parkinson-White syndrome (WPW) requires accurate evaluation of the site of bypass tract insertion. Doppler myocardial imaging (DMI) is a new ultrasound technique that allows the detection of abnormal and early regional myocardial depolarization. The purpose of this study was to identify an abnormal pathway site in WPW patients. Methods: Twenty-one patients with ventricular preexcitation were studied by DMI. Two-dimensional color DMI, velocity maps, acceleration maps, and pulsed-wave applications were used. A subsequent diagnostic EPS was performed. The results of EPS were taken as the gold standard diagnostic procedure. Radiofrequency catheter ablation therapy was then performed on all patients. Results: The anomalous pathway was detected by DMI in 16 (76%) of 21 patients (9 [90%] of 10 with left pathways and 7 [64%] of 11 with right pathways), with respect to results of the EPS. Pathway detection was better with pulsed-wave DMI (76%) with its higher temporal resolution as compared with M-mode velocity map (57%) and acceleration map (47%). In most of the patients with successful radiofrequency ablation, an immediate resolution of the abnormal ventricular depolarization occurred and was detectable by DMI. Conclusions: Our findings demonstrate the feasibility of DMI to assess the early ventricular contraction associated with atrioventricular accessory pathways. Therefore, DMI appears to be a clinically useful adjunct to noninvasive evaluation of abnormal myocardial depolarization in WPW and to evaluate the results after radiofrequency ablation, even though its accuracy is considerably better for left-sided accessory pathways than for right-sided ones.

Published
2002

143. Congenital junctional ectopic tachycardia in children and adolescents: A 20 year experience based study

Author

Valentino Ducceschi, B Musto, Berardo Sarubbi, C Cavallaro, A D‘Onofrio, F Vecchione, Raffaele Calabrò, C Musto, Sarubbi, B, Musto, B, Ducceschi, V, D'Onofrio, A, Cavallaro, C, Vecchione, F, Musto, C, and Calabro', Raffaele

Subjects
Tachycardia, Male, medicine.medical_specialty, Digoxin, Heart disease, Adolescent, Amiodarone, Physical examination, Propafenone, Scientific Letters, Internal medicine, Tachycardia, Ectopic Junctional, Junctional ectopic tachycardia, medicine, Humans, Medical history, cardiovascular diseases, Child, Flecainide, medicine.diagnostic_test, business.industry, medicine.disease, Cardiology, Drug Therapy, Combination, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, business, Anti-Arrhythmia Agents, medicine.drug
Abstract

Junctional ectopic tachycardia (JET) is a rare arrhythmia presenting either as a primary form1 or more often as a transient phenomenon immediately after heart surgery.2 Congenital JET usually occurs in the first six months of life as a persistent arrhythmia, associated in up to 60% of cases with cardiomegaly and/or heart failure.1 Congenital JET has been described in sporadic case reports or larger multicentre populations. The purpose of this study is to examine retrospectively the clinical presentation and outcome of a cohort of nine patients with congenital JET referred during a 20 year period time to a single unit and all medically treated. Nine patients (two male, seven female) suffering from persistent sustained JET were referred to our hospital between 1980 and 1999. All the patients underwent a complete medical history, physical examination, 12 lead ECG, 24 hour Holter recording, and echocardiogram. The diagnosis of JET was based on electrocardiographic evidence of a narrow complex tachycardia and atrioventricular dissociation. All the patients underwent medical treatment according to the following regimen: A Ic antiarrhythmic drug (propafenone or flecainide) was administered in combination with amiodarone when the latter proved ineffective alone in controlling the arrhythmia. This combination of drugs was also used in an attempt to reduce the dose of amiodarone, and prevent signs of …

144. Compatibility of Bioinsecticides with Parasitoids for Enhanced Integrated Pest Management of Drosophila suzukii and Tuta absoluta .

Author

Lisi F, Cavallaro C, Pitruzzello MF, Arnó J, Desneux N, Han P, Wang X, Zappalà L, Biondi A, and Gugliuzzo A

Abstract

Drosophila suzukii and Tuta absoluta are successful biological invaders of agroecosystems. Their integrated pest management (IPM) programs involve the release and/or conservation of natural enemies. Among these, Ganaspis kimorum is a major Asian parasitoid of D. suzukii and has been introduced as a classical biological control agent of this pest in Europe and North America, while Necremnus tutae is a key fortuitous parasitoid of T. absoluta in the Mediterranean region. Bioinsecticides represent key alternatives to chemicals for controlling both pests. This study investigated the potential compatibility of both parasitoids with Beauveria bassiana , Bacillus thuringiensis , garlic essential oil (EO), and spinosad, in comparison to two synthetic insecticides, cyantraniliprole and chlorantraniliprole. The results showed that combining each of the tested insecticides with G. kimorum slightly increased pest mortality compared to the insecticide alone. Necremnus tutae had a significant additive effect on host mortality when combined with insecticides. Beauveria bassiana and B. thuringiensis were most compatible with both parasitoid species. Both garlic EO and chlorantraniliprole impaired the survival of immature N. tutae and showed sublethal toxicity on the reproductive and non-reproductive behaviors of N. tutae . Spinosad exhibited high acute toxicity on both juvenile and adult parasitoids of both species. Overall, these findings provide useful insights into insecticide selectivity toward two key parasitoids and offer new knowledge on the potential of combining natural enemies and bioinsecticides for optimized IPM.

Published
2024
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145. The additive prognostic value of end-systolic pressure-volume relation by stress CMR in patients with known or suspected coronary artery disease.

Author

Meloni A, De Luca A, Nugara C, Cavallaro C, Cappelletto C, Barison A, Todiere G, Grigoratos C, Novo G, Grigioni F, Emdin M, Sinagra G, Mavrogeni S, Quaia E, Cademartiri F, and Pepe A

Subjects
Humans, Female, Male, Middle Aged, Aged, Prognosis, Time Factors, Risk Factors, Dipyridamole, Myocardium pathology, Contrast Media, Myocardial Perfusion Imaging methods, Arterial Pressure, Retrospective Studies, Coronary Artery Disease physiopathology, Coronary Artery Disease diagnostic imaging, Coronary Artery Disease mortality, Ventricular Function, Left, Predictive Value of Tests, Stroke Volume, Fibrosis, Magnetic Resonance Imaging, Cine, Myocardial Contraction, Vasodilator Agents
Abstract

Purpose: The difference between rest and peak stress end-systolic pressure-volume relation (ΔESPVR) is an afterload-independent index of left ventricular (LV) contractility. We assessed the independent prognostic value of ΔESPVR index by dipyridamole stress-cardiovascular magnetic resonance (CMR) in patients with known/suspected coronary artery disease (CAD)., Methods: We considered 196 consecutive patients (62.74 ± 10.66 years, 49 females). Wall motion and perfusion abnormalities at rest and peak stress were analysed. Replacement myocardial fibrosis was detected by late gadolinium enhancement (LGE) technique. The ESPVR was evaluated at rest and peak stress from raw measurement of systolic arterial pressure and end-systolic volume by biplane Simpson's method., Results: A reduced ΔESPVR index (≤ 0.02 mmHg/mL/m2) was found in 88 (44.9%) patients and it was associated with a lower LV ejection fraction (EF) and with a higher frequency of abnormal stress CMR and myocardial fibrosis. During a mean follow-up of 53.17 ± 28.21 months, 50 (25.5%) cardiac events were recorded: 5 cardiac deaths, 17 revascularizations, one myocardial infarction, 23 hospitalisations for heart failure or unstable angina, and 4 ventricular arrhythmias. According to Cox regression analysis, diabetes, family history, LVEF, abnormal stress CMR, myocardial fibrosis, and reduced ΔESPVR were significant univariate prognosticators. In the multivariate analysis the independent predictors were ΔESPVR index ≤ 0.02 mmHg/mL/m2 (hazard ratio-HR = 2.58, P = 0.007), myocardial fibrosis (HR = 2.13, P = 0.036), and diabetes (HR = 2.33, P = 0.012)., Conclusion: ΔESPVR index by stress-CMR was independently associated with cardiac outcomes in patients with known/suspected CAD, in addition to replacement myocardial fibrosis and diabetes. Thus, the assessment of ΔESPVR index may be included into the standard stress-CMR exam to further stratify the patients., (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)

Published
2024
Full Text
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146. Adequacy of health message tailoring for ethnic minorities: Pasifika communities in Sydney, Australia, during COVID-19.

Author

Palu E, McBride KA, Simmons D, Thompson R, Cavallaro C, Cooper E, Felila M, and MacMillan F

Subjects
Adult, Humans, Australia, Communication, Fear, Ethnic and Racial Minorities, COVID-19 prevention & control
Abstract

Ethnic minorities, such as Pasifika, residing in high-income countries were at higher risk of COVID-19 infection during the pandemic. To understand the experiences of Pasifika, including message dissemination and barriers to tailored public health messaging during the pandemic, a qualitative study was undertaken, underpinned by Laswell's Model of Communication and Bandura's social cognitive theory with data collected using Pasifika methods. Pasifika adults (n = 65) were recruited across Sydney from July 2020 to March 2022. Health care professionals (HCP) (n = 17) employed by four local health districts (LHDs) and Pasifika community-based organizations delivering multicultural COVID-19-related work within the study catchment, were also recruited. Five themes were constructed from the data of: (i) prevailing fear and uncertainty over COVID-19 infection and losing employment; (ii) limited knowledge of government perpetuating distrust in Government as a benevolent source of information; (iii) faith and trust as priorities for health decision-making; (iv) 'Coconut wireless'-the role of family, friends and community in disseminating public health messages through word of mouth; and (v) limited health literacy affecting compliance with public health orders. Community members identified important messages and resources had not been sufficiently distributed. Most HCPs understood the necessity of grassroots-level engagement but reported existing approaches were inadequate to navigate challenges. These findings highlight the need for public health promotion and communication strategies that consider both the social and cultural determinants of health. We propose a 7-point checklist as a cultural appropriateness lens to assist the development and rating of existing or new health promotion messaging and resources., (© The Author(s) 2024. Published by Oxford University Press. All rights reserved. For permissions, please email: journals.permissions@oup.com.)

Published
2024
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147. Sublethal effects of nine insecticides on Drosophila suzukii and its major pupal parasitoid Trichopria drosophilae.

Author

Lisi F, Mansour R, Cavallaro C, Alınç T, Porcu E, Ricupero M, Zappalà L, Desneux N, and Biondi A

Subjects
Animals, Female, Drosophila, Dimethoate, Malathion, Pupa, Insecticides toxicity, Hymenoptera
Abstract

Background: Although the pupal parasitoid Trichopria drosophilae is used in conservative and augmentative biocontrol of Drosophila suzukii infestations, current pest management strategies mostly rely on multiple insecticide applications. In this context, the aim of the study was to investigate the baseline toxicity of nine insecticides on D. suzukii larvae and their multiple sublethal effects (LC 10 ) on immature stages of the pest feeding on contaminated diet and T. drosophilae developing within the intoxicated host., Results: Chlorpyriphos and azadirachtin showed the lowest and the highest LC 10 , the values of which were 9.78 × 10 13 and 1.46 × 10 3 times lower than their recommended label field rate, respectively. Among tested insecticides, imidacloprid, malathion and dimethoate were the only treatments that did not affect the juvenile development time of D. suzukii, while spinosad and the organophosphates chlorpyriphos and dimethoate did not influence fly pupal size. No sublethal effects were recorded on T. drosophilae degree of infestation (DI) and juvenile development time. On the contrary, cyazypyr and dimethoate negatively affected the success of parasitism (SP) and the number of progeny of the pupal parasitoid, in association with malathion for the first parameter and spinosad for the fertility. Compared to the untreated control, more female progeny emerged following azadirachtin exposure, while dimethoate caused the opposite effect. Imidacloprid, lambda-cyhalothrin and spinetoram decreased hind tibia length of emerged parasitoids., Conclusion: This study provides new insights on the (eco)toxicological profile of nine insecticides and new information needed to support the deployment of T. drosophilae in the field within the sustainable management techniques against D. suzukii. © 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry., (© 2023 The Authors. Pest Management Science published by John Wiley & Sons Ltd on behalf of Society of Chemical Industry.)

Published
2023
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148. Leptin as predictor of cardiovascular events and high platelet reactivity in patients undergoing percutaneous coronary intervention.

Author

Ricottini E, Gatto L, Nusca A, Melfi R, Mangiacapra F, Albano M, Cavallaro C, Pozzilli P, Di Sciascio G, Prati F, Ussia GP, and Grigioni F

Subjects
Humans, Leptin, Platelet Aggregation Inhibitors, Treatment Outcome, Myocardial Infarction epidemiology, Myocardial Infarction etiology, Myocardial Infarction therapy, Percutaneous Coronary Intervention adverse effects
Abstract

Background and Aims: Leptin is a hormone involved in the regulation of food intake. Previous studies suggested an interplay between leptin, platelet aggregation, and cardiovascular outcome but this issue was not investigated in vivo in patients treated with percutaneous coronary intervention (PCI). We designed a study to evaluate the possible relation between leptin, cardiovascular outcome, and platelet reactivity (PR) in patients undergoing PCI., Methods: 155 PCI patients had preprocedural measurements of PR and leptin plasma levels. The latter were assessed by ELISA. Hyperleptinemia was defined as leptin levels ≥14 ng/ml. PR was evaluated by the VerifyNowP2Y12 assay and expressed as P2Y12 reaction units (PRU). Patients were divided into three groups based on PR values and defined as low (LPR), normal (NPR), and high (HPR). Patients were followed for up 8 years. The primary endpoint was the incidence of Major Acute Cardiac Events (MACE) at long-term follow-up according to leptin groups. Secondary endpoints were the evaluation of leptin levels according to PR groups and the incidence of periprocedural myocardial infarction (PMI) according to leptin groups., Results: Long-term follow-up was completed in 140 patients. Patients with hyperleptinemia experienced a higher MACE rate than the normoleptinemic group (HR 2.3; CI 95% 1.14-4.6, P = 0.02). These results remained unchanged after adjusting for Body Mass Index, hypertension, and gender. Leptin levels were significantly different among groups of PR (P = 0.047). Leptin levels were higher in the HPR group (12.61 ± 16.58 ng/ml) compared to the LPR group (7.83 ± 8.87 ng/ml, P = 0.044) and NPR group (7.04 ± 7.03 ng/ml, P = 0.01). The rate of PMI was higher in hyperleptinemia patients (15.1% vs. 6.5%, P = 0.22)., Conclusions: This study suggests that high leptin levels are associated with a worse clinical outcome in patients undergoing PCI and with HPR. Further studies are needed to define better the pathophysiological pathways underlying this association., Competing Interests: Declaration of competing interest All authors have nothing to declare concerning the present manuscript., (Copyright © 2023 European Society for Clinical Nutrition and Metabolism. Published by Elsevier Ltd. All rights reserved.)

Published
2023
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149. Discovering anomalies in big data: a review focused on the application of metaheuristics and machine learning techniques.

Author

Cavallaro C, Cutello V, Pavone M, and Zito F

Abstract

With the increase in available data from computer systems and their security threats, interest in anomaly detection has increased as well in recent years. The need to diagnose faults and cyberattacks has also focused scientific research on the automated classification of outliers in big data, as manual labeling is difficult in practice due to their huge volumes. The results obtained from data analysis can be used to generate alarms that anticipate anomalies and thus prevent system failures and attacks. Therefore, anomaly detection has the purpose of reducing maintenance costs as well as making decisions based on reports. During the last decade, the approaches proposed in the literature to classify unknown anomalies in log analysis, process analysis, and time series have been mainly based on machine learning and deep learning techniques. In this study, we provide an overview of current state-of-the-art methodologies, highlighting their advantages and disadvantages and the new challenges. In particular, we will see that there is no absolute best method, i.e., for any given dataset a different method may achieve the best result. Finally, we describe how the use of metaheuristics within machine learning algorithms makes it possible to have more robust and efficient tools., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2023 Cavallaro, Cutello, Pavone and Zito.)

Published
2023
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150. Additional value of T1 and T2 mapping techniques for early detection of myocardial involvement in scleroderma.

Author

Meloni A, Gargani L, Bruni C, Cavallaro C, Gobbo M, D'Agostino A, D'Angelo G, Martini N, Grigioni F, Sinagra G, De Caterina R, Quaia E, Mavrogeni S, Cademartiri F, Matucci-Cerinic M, and Pepe A

Subjects
Humans, Female, Male, Magnetic Resonance Imaging, Cine, Case-Control Studies, Gadolinium, Myocardium pathology, Predictive Value of Tests, Ventricular Function, Left, Contrast Media, Scleroderma, Systemic
Abstract

Background: We evaluated the prevalence of myocardial involvement by native T1 and T2 mapping, the diagnostic performance of mapping in addition to conventional Lake Louise Criteria (LLC), as well as correlations between mapping findings and clinical or conventional cardiovascular magnetic resonance (CMR) parameters in systemic sclerosis (SSc) patients., Methods: Fifty-five SSc patients (52.31 ± 13.24 years, 81.8% female) and 55 age- and sex-matched healthy subjects underwent clinical, bio-humoral assessment, and CMR. The imaging protocol included: T2-weighted, early post-contrast cine sequences, native T1 and T2 mapping by a segmental approach, and late gadolinium enhancement (LGE) technique., Results: Global myocardial T1 and T2 values were significantly higher in SSc patients than in healthy subjects. An increase in native T1 and/or T2 was present in the 62.1% of patients with normal conventional CMR techniques (negative LGE and T2-weighted images). Respectively, 13.5% and 59.6% of patients fulfilled original and updated LLC (overall agreement = 53.9%). Compared with patients with normal native T1, patients with increased T1 (40.0%) featured significantly higher left ventricular end-diastolic volume index and cardiac index, biventricular stroke volume indexes, and global heart T2 values, and more frequently had a history of digital ulcers. Biochemical and functional CMR parameters were comparable between patients with normal and increased T2 (61.8%)., Conclusion: T1 and T2 mapping are sensitive parameters that should be included in the routine clinical assessment of SSc patients for detecting early/subclinical myocardial involvement., Competing Interests: Declaration of Competing Interest The authors report no relationships that could be construed as a conflict of interest., (Copyright © 2023 Elsevier B.V. All rights reserved.)

Published
2023
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