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Private vehicle use contributes a disproportionately large amount to the degradation of the environment we inhabit. Technological advancement is of course critical to the mitigation of climate change, however alone it will not suffice; we must also see behavioural change. This paper will argue for the application of Ergonomics to the design of private vehicles, particularly low-carbon vehicles (e.g. hybrid and electric), to encourage this behavioural change. A brief review of literature is offered concerning the effect of the design of a technological object on behaviour, the inter-related nature of goals and feedback in guiding performance, the effect on fuel economy of different driving styles, and the various challenges brought by hybrid and electric vehicles, including range anxiety, workload and distraction, complexity, and novelty. This is followed by a discussion on the potential applicability of a particular design framework, namely Ecological Interface Design, to the design of in-vehicle interfaces that encourage energy-conserving driving behaviours whilst minimising distraction and workload, thus ensuring safety.

Systems design is plagued by criticism for failing to adequately define the role of the human within the system as a whole. Autonomous Emergency Braking (AEB) systems automate elements of the driving task by warning the driver of a collision risk and, if necessary, applying the brakes to reduce collision impact. As with all automated technologies, questions remain over whether or not AEB fundamentally changes the driving task by affecting the ways in which the driver interacts with vehicle systems. In order to address these concerns, Operator Sequence Diagrams have been developed to provide an insight into the roles of the driver and vehicle sub-systems in an emergency situation using the distributed cognition approach.

Environmental concerns show that transport is responsible for almost a quarter of all greenhouse gas emissions, and it is also the fastest growing sector. Modal shift towards public transport could help slow down, or even reverse, this trend. There appear to be a number of constraints that are preventing this from happening. This paper explores the constraints to modal shift to rail transport from the perspective of cognitive work analysis, specifically the abstraction hierarchy, the contextual activity template and social organisational and cooperation analyses. Whilst these analyses may not present any new barriers, they do show how the constraints are interlinked in an explicit manner. These interrelations are important for two reasons. First, in consideration of constraint removal, one must anticipate the likely effects on the remainder of the system. Second, by linking functions and situations, new concepts of travel may be identified and explored.Practitioner Summary:The purpose of this study was to use a semi-structured approach to identifying constraints to modal shift from a variety of perspectives. It is argued that cognitive work analysis offers a new way of thinking about the modal shift problem and helps to generate new insights into potential solutions.

This report describes the investigations into the cause and treatment of metabolic bone disease (MBD) in captive native New Zealand frogs (Leiopelma spp.) and the role of fluoride in the disease. MBD was diagnosed in Leiopelma archeyi and Leiopelma hochstetteri in 2008 at three institutions: Auckland Zoo, Hamilton Zoo, and the University of Otago. Most of these frogs had originally been held at the University of Canterbury for several years (2000-2004) but some were collected directly from the wild. Radiographs on archived and live frogs showed that MBD had been present at Canterbury, but at a lower rate (3%) than in the current institutions (38-67%). Microcomputed tomography showed that the femoral diaphyses of the captive frogs at Auckland Zoo had greater bone volume, bone surface, cross-sectional thickness, and mean total cross-sectional bone perimeter, which is consistent with osteofluorosis. On histology of the same femurs, there was hyperplasia, periosteal growth, and thickening of trabeculae, which are also consistent with skeletal fluorosis. An increase in fluoride levels in the water supply preceded the rise in the incidence of the above pathology, further supporting the diagnosis of osteofluorosis. Analysis of long-standing husbandry practices showed that ultraviolet B (UVB) exposure and the dietary calcium:phosphorus ratio were deficient when compared with wild conditions-likely causing chronic underlying MBD. To prevent multifactorial MBD in captive Leiopelma, the authors recommend increasing dietary calcium by incorporating into the captive diet inherently calcium-rich invertebrates; increasing exposure to natural or artificial (UVB) light; and using defluoridated water. Addressing these three factors at Auckland Zoo reduced morbidity, bone fractures, and mortality rates.

River flow records are fundamental for the sustainable management of water resources and even very short gaps can severely compromise their utility. Suitably-flagged flow estimates, derived via judicious infilling, are potentially highly beneficial to data users. The UK National River Flow Archive provides stewardship of, and access to, UK river flow records. While many datasets held on the archive are complete, gaps remain across a wide range of flow records. A comprehensive assessment of existing techniques for infilling these gaps is currently lacking. This paper therefore assesses 15 simple infilling techniques (including regression, scaling and equipercentile approaches), each relying upon data transfer from hydrologically-similar donor stations, to generate estimates of flow at 26 representative gauging stations. Results reveal the overall superiority of equipercentile and multiple regression techniques compared to the poorer capability of catchment area scaling. Donor station choice has a strong influence on technique performance. Modifying datasets to improve homogeneity, by seasonally grouping flows or excluding certain periods, offers improved performance. These findings provide a foundation upon which guidance on infilling river flow records can be based in future, allowing hydrometric practitioners and data end-users alike to adopt a consistent and auditable approach towards infilling.

The role of the adult oncologists in the area of pediatric cancer treatment previously has been unmeasured. A questionnaire bearing regarding the practice of 447 adult oncologists was administered in June 1991. The membership list of the Association of Community Cancer Centers was used to identify contact oncologists. One hundred thirty-one questionnaires (29.3%) were returned for analysis. The data reveal that 204 patients younger than 21 years of age were treated during the last year in 63 adult oncology practices. Most of these patients were more than 15 years of age. Only a minority (53) were treated in rural practices. In addition, only a minority (27%) of these patients are reported to be enrolled in clinical trials

Complete river flow time series are indispensable to the sustainable management of water resources and even very short gaps can severely compromise data utility. Suitably-flagged flow estimates, derived via judicious infilling, are thus highly beneficial. The UK National River Flow Archive provides stewardship of and access to daily river flow records from over 1500 gauging stations and, whilst the majority are sensibly complete, historical validation reveals a significant quantity of gaps. A full assessment of the suitability of existing techniques for infilling such gaps is lacking. This paper therefore presents an appraisal of various simple infilling techniques, including regression, scaling and equipercentile analysis, according to their ability to generate daily flow estimates for 25 representative UK gauging stations. All of the techniques rely upon data transfer from donor stations and results reveal that the equipercentile and multiple regression approaches perform best. Case studies offer further insight and an example of infilling is presented, along with areas of future study. The results demonstrate the potential for developing generic infilling methodologies to ensure a consistent and auditable approach towards infilling, which could find wider application both within the UK and internationally.

Hearing preservation in acoustic neuroma surgery is possible in a limited number of cases. Although there have been many articles published about hearing preservation, there have been few studies of long-term hearing results, nor is it known if there is an increased rate of tumor recurrence when hearing preservation is attempted. Twenty-two patients who underwent a hearing preservation procedure via the retrosigmoid approach were selected from 80 consecutive patients with cerebellopontine angle tumors operated on from February 1984 to November 1987. Useful hearing was retained in 11 cases as reported in a previously published study. Seven patients continue to have useful hearing after 3 to 5 years; 3 have shown a gradual but slight decline. There has been no tumor recurrence in these patients, but 2 patients, operated on early in the series and who had lost hearing, had recurrent tumor.

Usability must be defined specifically for the context of use of the particular system under investigation. This specific context of use should also be used to guide the definition of specific usability criteria and the selection of appropriate evaluation methods. There are four principles which can guide the selection of evaluation methods, relating to the information required in the evaluation, the stage at which to apply methods, the resources required and the people involved in the evaluation. This paper presents a framework for the evaluation of usability in the context of In-Vehicle Information Systems (IVISs). This framework guides designers through defining usability criteria for an evaluation, selecting appropriate evaluation methods and applying those methods. These stages form an iterative process of design-evaluation-redesign with the overall aim of improving the usability of IVISs and enhancing the driving experience, without compromising the safety of the driver.

Cancer care is evolving from a solo practitioner care delivery system based on tradition and anecdotal experience to a multidisciplinary, collaborative, science-driven paradigm. Evidence-based practice facilitates optimal care quality for patients with cancer and is effected for medical and nursing practitioners through clinical practice guideline implementation. Clinician education based on principles of adult learning is one method of implementing clinical practice guidelines in clinical practice. However, research demonstrates that conventional static methods of education do little to change behavior; instead, effective education incorporates interactive formats, provides feedback, and includes reminder and reinforcement strategies. The EDUCATE (Educating Clinicians to Achieve Treatment Guideline Effectiveness) Study offers one model for clinical practice guideline implementation using educational methods. A faculty of nurse educators, together with practice champions, carried out an intensive educational intervention comprised of multiple teaching/learning activities during a 12-month period in community oncology practices throughout the United States. In addition to an overview of clinical practice guidelines and educational methods that can be used for implementation of clinical practice guidelines, the obstacles faced and lessons learned through the EDUCATE Study are presented, along with recommendations for implementation in the practice setting.

This study presents a case study to explore an analytic approach to the evaluation of in-vehicle information system (IVIS) usability, aimed at an early stage in product development with low demand on resources. Five methods were selected: hierarchical task analysis (HTA), multimodal critical path analysis (CPA), systematic human error reduction and prediction approach (SHERPA), heuristic analysis and layout analysis. The methods were applied in an evaluation of two IVIS interfaces: a touch screen and a remote controller. The findings showed that there was a trade-off between the objectivity of a method and consideration of the context of use: this has implications for the usefulness of analytic evaluation. An extension to the CPA method is proposed as a solution to enable more objective comparisons of IVIS, whilst accounting for context in terms of the dual-task driving environment.

Fungal disease in reptiles is common, and can often lead to fatal systemic disease. Of the many fungal species isolated from reptiles most are environmental saphrophytes. Predisposing factors to in...

Bacterial biofilms can initiate chronic infections that become difficult to eradicate. There is an unmet need for effective therapeutic strategies that control and inhibit the growth of these biofilms. Herein, light sensitive mesoporous silica nanoparticles (MSNs) with photothermal (PTT) and antimicrobial combined capabilities have been developed. These nanosystems have high therapeutic potential to affect the bacterial biofilm architecture and subsequently inhibit its growth. Nucleation of gold nanorods followed by the growth of a silica shell leads to a core@shell design (AuNR@MSN) with PTT properties. Incorporation of nitrosothiol groups (-SNO) with a heat liable linker, enables an enhanced nitric oxide release upon photothermal stimulation with near infrared radiation. Further loading of an antimicrobial molecule such as the levofloxacin (LEVO) antibiotic creates a unique nanoassembly with potential therapeutic efficacy against Staphylococcus aureus bacterial biofilms. A dispersion rate of the bacterial biofilm was evident when light stimuli is applied because impregnation of the nitrosothiol functionalized nanosystem with the antibiotic LEVO led to ca. 30% reduction but its illumination with near infrared (NIR) irradiation showed a biofilm reduction of ca. 90%, indicating that localized antimicrobial exposure and PTT improves the therapeutic efficacy. These findings envision the conception of near-infraredactivated nanoparticle carriers capable of combined therapy upon NIR irradiation, which enables photothermal therapy, together with the release of levofloxacin and nitric oxide to disrupt the integrity of bacterial biofilms and achieve a potent antimicrobial therapy., 23 pages, 5 figures