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102. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017
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Roth, Gregory A., Collaborotors, G. B. D.Causes Death, Abate, Degu, Abate, Kalkidan Hassen, Abay, Solomon M., Abbafati, Cristiana, Abbasi, Nooshin, Abbastabar, Hedayat, Abd-Allah, Load, Abdela, Jemal, Abdelalim, Ahmed, Abdollahpour, Ibrahim, Abdulkader, Rizwan Suliankatchi, Abebe, Haftom Temesgen, Abebe, Molla, Abebe, Zegeye, Abejie, Ayenew Negesse, Abera, Semaw F., Abil, Olifan Zewdie, Abraha, Haftom Niguse, Abrham, Aklilu Roba, Abu-Raddad, Laith Jamal, Accrombessi, Manfred Mario Kokou, Acharya, Dilaram, Adamu, Abdu A., Adebayo, Oladimeji, Adedoyin, Rufus Adesoji, Adekanmbi, Victor, Adookunboh, Olatunii, Adhena, Beyene Meressa, Adib, Mina G., Admasie, Aniha, Afshin, Ashkan, Agarwal, Gina, Agesa, Karelia M., Agrawal, Anurag, Agrawal, Sutapa, Ahmadi, Alireza, Ahmadi, Melidi, Ahmed, Muktar Beshir, Ahmed, Sayent, Aichour, Amani Nidhal, Aichour, Ibtihel, Aichour, Miloud Taki Fddine, Akbari, Mohammad Esmaeil, Akinyeniti, Rufus Olusola, Akseer, Nadia, Al-Aly, Ziyad, Al-Eyadhy, Ayman, Al-Raddadi, Rajaa M., Alandab, Fares, Alam, Khurshid, Alam, Tahiya, Alebel, Animut, Alene, Kefyalew Addis, Alijanzadeh, Mehran, Alizadeh-Navaei, Reza, Aljunid, Syed Mohamed, Alkerwi, Ala'a, Alla, Francois, Allebeck, Peter, Alonso, Jordi, Altirkawi, Khalid, Alvis-Guzman, Nelson, Amare, Azmeraw T., Aminde, Leopold N., Amini, Erfan, Ammar, Walid, Amoako, Yaw Ampern, Anber, Nahla Hamed, Andrei, Catalina Liliana, Androudi, Sofia, Animut, Megbaru Debalkie, Anjomshoa, Mina, Ansari, Hossein, Aniha, Mustafa Geleto, Antonio, Carl Abelardo T., Anwari, Palwasha, Aremu, Olatunde, Arnlov, Johan, Arora, Amit, Arora, Monika, Artaman, Al, Aryal, Krishna K., Asayesh, Hamid, Asfaw, Ephremi Tsegay, Ataro, Zerihun, Atique, Suleman, Atre, Sachin R., Ausloos, Marcel, Avokpaho, Euripide F. G. A., Awasthi, Ashish, Quintattilla, Beatriz Paulina Ayala, Ayele, Yohanes, Ayer, Rakesh, Azzopardi, Peter S., Babazadeh, Arefeh, Bacha, Umar, Badali, Hamid, Badawi, Alaa, Bali, Ayele Geleto, Ballesteros, Katherine E., Banach, Maciej, Banerjee, Kajori, Bannick, Marlena S., Banoub, Joseph Adel Mattar, Barboza, Miguel A., Barker-Collo, Suzanne Lyu, Barnighausen, Till Winfried, Barquera, Simon, Barrero, Lope, Bassat, Quique, Base, Sanjay, Baune, Bernhard T., Baynes, Habtamu Wondifraw, Bazargan-Hejazi, Shahrzad, Beth, Neeraj, Beghi, Ettore, Behzadifar, Masoud, Behzadifar, Mcysam, Bejot, Yannick, Bekele, Bayu Begashaw, Belacliew, Abate Bekele, Belay, Ezra, Belay, Yihalem Abebe, Bell, Michelle L., Bello, Aminu K., Bennett, Derrick A., Bensenor, Isabela M., Berman, Adam F., Bernabe, Eduardo, Bernstein, Robert S., Bertolacci, Gregory J., Beuran, Mircea, Beyranvand, Tina, Bhalla, Ashish, Bhattarai, Suraj, Bhaumik, Sounayadeeep, Bhutta, Zulfiqar A., Biadgo, Belete, Biehl, Molly H., Bijani, Ali, Bikbov, Boris, Bilano, Ver, Bililign, Nigus, Bin Sayeed, Muhammad Shandaat, Bisanzio, Donal, Biswas, Tuhin, Blacker, Brigitte F., Basara, Berrak Bora, Borschmann, Rohan, Bosetti, Cristina, Bozorgmehr, Kayvan, Brady, Oliver J., Brant, Luisa C., Brayne, Carol, Brazinova, Alexandra, Breitborde, Nicholas J. K., Brenner, Hermann, Briant, Paul Svitil, Britton, Gabrielle, Brugha, Traolach, Busse, Reinhard, Butt, Zahid A., Callender, Charlton S. K. H., Campos-Nonato, Ismael R., Rincon, Julio Cesar Canapuzano, Cano, Jorge, Car, Mate, Cardenas, Rosario, Carreras, Giulia, Carrero, Juan J., Carter, Austin, Carvalho, Felix, Castaneda-Orjuela, Carlos A., Rivas, Jacqueline Castillo, Castle, Chris D., Castro, Clara, Castro, Franz, Catala-Lopez, Ferran, Cerin, Ester, Chaiah, Yazan, Chang, Jung -Chen, Chanson, Fiona J., Chaturvedi, Pankaj, Chiang, Peggy Pei-Chia, Chimed-Ochir, Odgerel, Chisumpa, Vesper Hichilombwe, Chitheet, Abdulaal, Chowdhury, Rajiv, Christensen, Hanne, Christopher, Devasahayam J., Chiang, Sheng-Chia, Cicuttini, Flavia M., Ciobanu, Liliana G., Cirillo, Massimo, Cohen, Aaron J., Cooper, Leslie Trumbull, Cortesi, Paolo Angelo, Cortinovis, Monica, Cousin, Ewerton, Cowie, Benjamin C., Criqui, Michael H., Cromwell, Elizabeth A., Crowe, Christopher Stephen, Crump, John A., Cunningham, Matthew, Daba, Alemneh Kabeta, Dadi, Abel Fekadu, Dandona, Lalit, Dandona, Rakhi, Dang, Anh Kim, Dargan, Paul I., Daryani, Ahmad, Das, Siddharth K., Das Gupta, Rajat, Das Neves, Jose, Dasa, Tamirat Tesfaye, Dash, Aditya Prasad, Davis, Adrian C., Weaver, Nicole Davis, Davitoiu, Dragos Virgil, Davletov, Kairat, De La Hoz, Fernando Pio, De Neve, Jan-Walter, Degefa, Meaza Girma, Degenhardt, Louisa, Degfie, Tizta T., Deiparine, Selina, Demoz, Gebre Teklemariam, Demtsu, Baleen Betsu, Denova-Gutierrez, Edgar, Deribe, Kebede, Dervenis, Nikolaos, Jarlais, Don C. Des, Dessie, Getenet Ayalew, Dey, Subhojit, Dhannaratne, Samath D., Dicker, Daniel, Dinberu, Mesfin Tadese, Ding, Eric L., Dirac, M. Ashworth, Djalalinia, Shirin, Dokova, Klara, Ter Doku, David, Donnelly, Christl A., Dorsey, E. Ray, Doshi, Pratik P., Douwes-Schultz, Dirk, Doyle, Kerrie E., Driscoll, Tim R., Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Duncan, Bruce B., Duraes, Andre R., Ebrahimi, Hedyeh, Ebrahimpour, Soheil, Edessa, Dumessa, Edvardsson, David, Eggen, Anne Elise, El Bcheraoui, Charbel, Zaki, Maysaa El Sayed, El-Khatib, Ziad, Elkout, Hajer, Eltinsel, Christian Lycke, Endres, Matthias, Endries, Aman Yesuf, Er, Benjamin, Erskine, Holly E., Eshrati, Babak, Eskandarieh, Sharareh, Esmaeili, Reza, Esteghamati, Alireza, Fakhar, Mahdi, Fakhim, Hamed, Faramarzi, Mahbobeh, Fareed, Mohammad, Farhadi, Farzaneh, Faninha, Carla Sofia E. Sa, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Farzaei, Mohammad Hosein, Feign, Valery L., Feigl, Andrea B., Fentahun, Netsanet, Eereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Fernandes, Joao C., Ferrari, Alice J., Feyissa, Garumma Tolu, Filip, Irina, Finegold, Samuel, Fischer, Florian, Eitzmaurice, Christina, Foigt, Nataliya A., Foreman, Kyle J., Fornari, Carla, Frank, Tahvi D., Fukumoto, Takeshi, Fuller, John E., Fullman, Nancy, Furst, Thomas, Furtado, Joao M., Futran, Neal D., Gallus, Silvano, Garcia-Basteiro, Alberto L., Garcia-Gordillo, Miguel A., Gardner, William M., Gebre, Abadi Kahsu, Gebrehiwol, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Gebremichael, Bereket, Gebremichael, Teklu Gebrehiwo, Gelano, Tilayie Feto, Geleijinse, Johanna M., Genova-Maleras, Ricard, Geramo, Yilma Chisha Dea, Gething, Peter W., Gezae, Kebede Embaye, Ghadami, Mohammad Rasoul, Ghadimi, Reza, Falavarjani, Khalil Ghasemi, Ghasemi-Kasman, Maryam, Ghimire, Mamata, Gibney, Katherine B., Gill, Paramjit Singh, Gill, Tiffany K., Gillum, Richard F., Ginawi, Ibrahim Abdelmageed, Giroud, Maurice, Giussani, Giorgia, Goenka, Shifalika, Goldberg, Ellen M., Goli, Srinivas, Gomez-Dantes, Hector, Gona, Philimon N., Gopalani, Sameer Vali, Gorman, Taren M., Goto, Atsushi, Goulart, Alessandra C., Gnedovskaya, Elena V., Grada, Aymara, Grosso, Giuseppe, Gugnani, Hanish Chander, Guimaraes, Andre Luiz Sena, Gun, Nailing, Gupta, Prakash C., Gupta, Rahid, Gupta, Rajenv, Gupta, Tanush, Gutierrez, Reyna Alma, Gyawali, Bishal, Haagsma, Juanita A., Hafezi-Nejad, Nima, Hagos, Tekleberhan B., Hailegiyorgis, Tewodros Tesfa, Hailu, Gessessew Bugssa, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamadeh, Randall R., Hamidi, Sinner, Handal, Meads J., Hankey, Graeme J., Harb, Hilda L., Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hasan, Mehedi, Hassankhani, Hadi, Hassen, Hamid, Havmoeller, Rasmus, Hay, Roderick J., Hay, Simon I., He, Yihua, Hedayatizadeh-Omran, Akbar, Hegazy, Mohamed I., Heibati, Behzad, Heidari, Mohsen, Hendrie, Delia, Henok, Andualem, Henry, Nathaniel J., Herteliu, Claudiu, Heydarpour, Fatemeh, Heydarpour, Pouria, Heydarpour, Sousan, Hibstu, Desalegn Tsegaw, Hoek, Hans W., Hole, Michael K., Red, Enayatollah Homaie, Hoogar, Praveen, Hosgood, H. Dean, Hosseini, Seyed Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian C., Hsiao, Thomas, Hu, Guoqing, Huang, John J., Husseini, Abdullatif, Hussen, Mohammedaman Mama, Hutfless, Susan, Idrisov, Bulat, Ilesanmi, Olayinka Stephen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, Nazrul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Jacobsen, Kathryn H., Jahangiry, Leila, Jahanmehr, Nader, Jain, Sudhir Kumar, Jakovlievic, Mihajlo, Jalu, Moti Tolera, James, Spencer L., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jenkins, Kathy J., Jha, Ravi Prakash, Jha, Vivekanand, Johnson, Catherine O., Johnson, Sarah C., Jonas, Jost B., Joshi, Ankur, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Jurisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalani, Rizwan, Karami, Manoochehr, Matin, Behzad Karami, Karch, Andre, Karema, Corine, Karimi-Sari, Hamidreza, Kasaeian, Amir, Kassa, Dessalegn H., Kassa, Getachew Mullu, Kassa, Tesfaye Dessale, Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kaul, Anil, Kazemi, Zhila, Karyani, Ali Kazemi, Kazi, Dhruv Satish, Kefale, Adane Teshome, Keiyoro, Peter Njenga, Kemp, Grant Rodgers, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khafaei, Behzad, Khafaie, Morteza Abdullatif, Khajavi, Alireza, Khalid, Nauman, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Muhammad Shahzeb, Khan, Muhammad Ali, Khang, Young-Ho, Khater, Mona M., Khoja, Abdullah T., Khosravi, Ardeshir, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kiadaliri, Aliasghar A., Kibret, Getiye D., Kidanemariam, Zelalem Teklemariam, Kiirithio, Daniel N., Kim, Daniel, Kim, Young-Eun, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kisa, Adnan, Kissimova-Skarbek, Katarzyna, Kivimaki, Mika, Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M., Kochhar, Sonali, Kokubo, Yoshihiro, Kolola, Tufa, Kopec, Jacek A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael A., Krishan, Kewal, Defo, Barthelemy Kuate, Bicer, Burcu Kinuk, Kumar, G. Anil, Kumar, Manasi, Kumar, Pushpendra, Kutz, Michael J., Kuzin, Igor, Kyu, Hmwe Hmwe, Lad, Deepesh P., Lad, Sheetal D., Lafranconi, Alessandra, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lam, Jennifer O., Lami, Faris Hasan, Van Lansingh, C., Lansky, Sonia, Larson, Heidi J., Latifi, Amman, Lau, Kathryn Mei-Ming, Lazarus, Jeffrey V., Lebedev, Georgy, Lee, Paul H., Leigh, James, Leili, Mostafa, Leshargie, Cheru Tesema, Li, Shanshan, Li, Yichong, Liang, Juan, Lim, Lee-Ling, Lim, Stephen S., Limenih, Miteku Andualem, Linn, Shai, Liu, Shiwei, Liu, Yang, Lodha, Rakesh, Lansdale, Chris, Lopez, Alan D., Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lunevicius, Raimundas, Ma, Stefan, Macarayan, Erlyn Rachelle King, Mackay, Mark T., MacLachlan, Jennifer H., Maddison, Emilie R., Nadotto, Fabiana, Abd El Razek, Hassan Magdy, Abd El Razek, Muhammed Magdy, Maghavani, Dhaval P., Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manda, Ana-Laura, Mandarano-Filho, Luiz Garcia, Manguerra, Helena, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Marami, Dadi, Maravilla, Joemer C., Marcenes, Wagner, Marczak, Laurie, Marks, Ashley, Marks, Guy B., Martinez, Gabriel, Martins-Melo, Francisco Rogerlandio, Martopullo, Ira, Marz, Winfried, Marron, Melvin B., Masci, Joseph R., Lylassenburg, Benjamin Ballard, Mathur, Manu Raj, Mathur, Prashant, Matzopoulos, Richard, Maulik, Pallab K., Mazidi, Mohsen, McAlinden, Cohn, McGrath, John J., McKee, Martin, McMahon, Brian J., Mehata, Suiiesh, Mehndiratta, Man Mohan, Mehrotra, Ravi, Mehta, Kala M., Mehta, Varshil, Mekonnen, Tefera C., Melese, Addisu, Melku, Mulugeta, Memiah, Peter T. N., Memish, Ziad A., Mendoza, Walter, Mengistu, Desalegn Tadese, Mengistu, Getnet, Mensah, George A., Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J., Meshovic, Tbmislav, Mezgebe, Haftay Berhane, Miazgowski, Bartosz, Miazgowski, Tomasz, Millear, Anoushka I., Miller, Ted R., Katherine, Molly, Petrie, Miller, Mini, G. K., Mirabi, Parvaneh, Mirarefin, Mojde, Mirica, Andreea, Mirrakhimov, Erkin M., Misganaw, Awoke Temesgen, Mitiku, Habtamu, Moazen, Babak, Mohammad, Karzan Abdulmuhsin, Mohammad, Moslem, Mohammadifard, Noushin, Mohammed, A. Mohammed, Mohammed, Shafiu, Mohan, Viswanathan, Mokdad, Ali H., Molokhia, Mariam, Monasta, Lorenzo, Moradi, Ghobad, Moradi-Lakeh, Maziar, Moradinazar, Mehdi, Moraga, Paula, Morawska, Lidia, Velasquez, Ilais Moreno, Morgado-Da-Costa, Joana, Morrison, Shane Douglas, Moschos, Marilita M., Mouodi, Simin, Mousavi, Seyyed Meysam, Muchie, Kindie Eentahun, Mueller, Ulrich Otto, Mukhopadhyay, Satinath, Muller, Kate, Mumford, John Everett, Musa, Jonah, Musa, Kamand Imran, Mustafa, Ghulam, Muthupandian, Saravanan, Nachega, Jean B., Nagel, Gabriele, Naheed, Aliya, Nahvijou, Azin, Naik, Gunidatta, Nair, Sanjeev, Najafi, Farid, Naldi, Luigi, Nam, Hae Sung, Nangia, Vinay, Nansseu, Jobert Richie, Nascirnento, Bruno Ramos, Natarajan, Gopalakrishnan, Nearnati, Nahid, Negoi, Ionut, Negoi, Ruxcandra Irina, Nettpane, Subas, Newton, Charles R. J., Ngalesoni, Frida N., Ngunjiri, Josephine W., Anh Quynh Nguyen, Nguyen, Grant, Ha Thu Nguyen, Luong Thanh Nguyen, Long Hoang Nguyen, Nguyen, Minh, Trang Huyen Nguyen, Nichols, Emma, Ningnun, Dina Nur Anggraini, Nirayo, Yirga Legesse, Nixon, Molly R., Nolutshungu, Nomonde, Nomura, Shhhei, Norhelin, Ole F., Noroozi, Mehdi, Norrving, Bo, Noubiap, Jean Jacques, Nouri, Hamid Reza, Shiadeh, Malihe Nourollahpour, Nowroozi, Mohammad Reza, Nyasulu, Peter S., Odell, Christopher M., Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olagunju, Andrew T., Olivares, Pedro R., Olsen, Helen Elizabeth, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin L., Ong, Sok King Sk, Oren, Eyal, Orpana, Heather M., Ortiz, Alberto, Ortiz, Justin R., Otstavnov, Stanislav S., Overland, Simon, Owolabi, Mayowa Ojo, Ozdemir, Raziye, Mahesh, P. A., Pacella, Rosana, Pakhale, Smita, Pakhare, Abhijit P., Pakpour, Amir H., Pana, Adrian, Panda-Jonas, Songhomitra, Pandian, Jeyaraj Durai, Parisi, Andrea, Park, Eun-Kee, Parry, Charles D. H., Parsian, Hadi, Patel, Shanti, Pati, Sanghamitra, Patton, George C., Paturi, Vishnupriya Rao, Paulson, Katherine R., Pereira, Alexandre, Pereira, David M., Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael R., Piel, Frederic B., Pigott, David M., Pillay, Julian David, Pirsaheb, Meghdad, Pishgar, Farhad, Polinder, Suzanne, Postma, Maarten J., Pourshams, Akram, Poustchi, Hossein, Pujar, Ashwini, Prakash, Swayam, Prasad, Narayan, Purcell, Caroline A., Qorbani, Mostafa, Quintana, Hedley, Quistberg, D. Alex, Rade, Kirankumar Waman, Radfah, Amir, Rafay, Anwar, Rafiei, Alireza, Rahim, Fakher, Rahimi, Kazem, Rahimi-Movaghar, Afarin, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Ranabhat, Chhabi Lal, Ranjan, Prabhat, Rao, Puja C., Rawaf, David Laith, Rawaf, Salman, Razo-Garcia, Christian, Reddy, K. Srinath, Reiner, Robert C., Reitsma, Marissa B., Remuzzi, Giuseppe, Renzaho, Andre M. N., Resnikoff, Serge, Rezaei, Satar, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Riahi, Seyed Mohammad, Ribeiro, Antonio Luiz P., Rios-Blancas, Maria Jesus, Roba, Kedir Teji, Roberts, Nicholas L. S., Robinson, Stephen R., Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rostami, Ali, Rothenbacher, Dietrich, Roy, Ambuj, Rubagotti, Enrico, Sachdev, Perminder S., Saddik, Basema, Sadeghi, Ehsan, Safari, Hosein, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salam, Nasir, Salama, Joseph S., Salamati, Payman, De Saldanha, Raphael Freitas, Saleem, Zikria, Salimi, Yahya, Salvi, Sundeep Santosh, Salz, Inbal, Sambala, Evanson Zondani, Samy, Abdatiah M., Sanabria, Juan, Sanchez-Nino, Maria Dolores, Santomauro, Damian Francesco, Santos, Itamar S., Santos, Joao Vasco, Milicevic, Milena M. Santric, Jose, Bruno Piassi Sao, Sarker, Abdur Razzaque, Sarmiento-Suarez, Rodrigo, Sarrafzadegan, Nizal, Sartorius, Benn, Sarvi, Shahabeddin, Sathian, Brijesh, Satpathy, Maheswar, Sawant, Arundhati R., Sawhney, Monika, Saxena, Sonia, Sayyah, Mehdi, Schaeffher, Elke, Schmidt, Maria Ines, Schneider, Ione J. C., Schottker, Ben, Schutte, Aletta Elisabeth, Schwebel, David C., Schwendicke, Falk, Scott, James G., Sekerija, Mario, Sepanlou, Sadaf G., Servan-Mori, Edson, Seyedmousavi, Seyedmojtaba, Shabaninejad, Hosein, Shackelford, Katya Anne, Shafieesabet, Azadeh, Shahbazi, Mehdi, Shaheen, Amira A., Shaikh, Masood Ali, Shams-Beyranvand, Mehran, Shamsi, Mohammadbagher, Shamsizadeh, Morteza, Sharafi, Kiomars, Sharif, Mehdi, Sharif-Alhoseini, Mandi, Sharma, Rajesh, She, Jun, Sheikh, Aziz, Shi, Peilin, Shiferaw, Mekonnen Sisav, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shiue, Ivy, Shokraneh, Farhad, Shrine, Mark G., Si, Si, Siabani, Soraya, Siddiqi, Tariq J., Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silberberg, Donald H., Silva, Diego Augusto Santos, Silva, Joao Pedro, Da Silva, Natacha Torres, Silveira, Dayane Bride Alves, Singh, Jasvinder A., Singh, Narinder Pal, Singh, Prashant Kumar, Singh, Virendra, Sinha, Dhirendra Narain, Sliwa, Karen, Smith, Mari, Sobaih, Badr Hasan, Sobhani, Soheila, Solangwi, Eugene, Soneji, Samir S., Soofi, Moslem, Sorensen, Reed J. D., Soriano, Joan B., Soyiri, Ireneous N., Sposato, Luciano A., Sreeramareddy, Chandrashekhar F., Srinivasan, Vinay, Stanaway, Jeffrey D., Starodubov, Vladimir I., Stathopoulou, Vasiliki, Stein, Dan J., Steiner, Caitlyn, Stewart, Leo G., Stokes, Mark A., Subart, Michelle L., Sudaryanto, Agus, Sufiyan, Mu'awiyyah Babale, Sur, Patrick John, Sutradhar, Ipsita, Sykes, Bryan L., Sylaja, P. N., Sylte, Dillon O., Szoeke, Cassandra E. I., Tabares-Seisdedos, Rafael, Tabuchi, Takahiro, Tadakamadla, Santosh Kumar, Takahashi, Ken, Tandon, Nikhil, Tassew, Segen Gebremeskel, Taveira, Nuno, Tehrani-Banihashemi, Arash, Tekalign, Tigist Gashaw, Tekle, Merhawi Gebremedhin, Temsah, Mohamad-Hani, Temsah, Omar, Terkawi, Abdullah Sulieman, Teshale, Manaye Yihune, Tesserna, Belay, Tessema, Gizachew Assefa, Thankappan, Kavumpurathu Raman, Thirinavukkarasu, Sathish, Thomas, Nihal, Thrift, Amanda G., Thurston, George D., Tilahun, Binyam, To, Quyen G., Tobe-Gai, Ruoyan, Tonellli, Marcello, Topor-Madry, Roman, Torre, Anna E., Tortajada-Cirbes, Miguel, Touvier, Mathilde, Tovani-Palone, Marcos Roberto, Bach Xuan Tran, Khah Bao Tran, Tripathi, Suryakant, Troeger, Christopher E., Truelsen, Thomas Clement, Nu Thi Truong, Tsadik, Afewerki Gebremeskel, Tsoi, Derrick, Car, Lorainne Tudor, Tuzcu, E. Murat, Tyrovolas, Stefanos, Ukwaja, Kingsley N., Whiff, Irfan, Undurraga, Eduardo A., Updike, Rachel L., Usman, Muhammad Shariq, Uthman, Olalekan A., Uzun, Selen Begum, Vaduganathan, Muthiah, Vaezi, Afsane, Vaidya, Gaurang, Valdez, Pascual R., Varavikova, Elena, Vasankari, Tommi Juhani, Venketasubramanian, Narayanaswamy, Villafaina, Santos, Violante, Francesco S., Vladimirov, Sergey Konstantinovitch, Vlassov, Vasily, Vollset, Stein Email, Vos, Theo, Wagner, Gregory R., Wagnew, Fasil Shiferaw, Waheed, Yasir, Wallin, Mitchell Taylor, Watson, Judd L., Wang, Yanping, Wang, Yuan-Pang, Wassie, Molla Mesele, Weiderpass, Elisabete, Weintraub, Robert G., Weldegebreal, Eitsum, Weldegwergs, Kidu Gidey, Werdecker, Andrea, Werkneh, Adhena Ayaliew, West, T. Eoin, Westerman, Ronny, Whiteford, Harvey A., Widecka, Justyna, Wilner, Lauren B., Wilson, Shadrach, Winkler, Andrea Sylvia, Wiysonge, Charles Shey, Wolfe, Charles D. A., Wu, Shouling, Wu, Yun-Chun, Wyper, Grant M. A., Xavier, Denis, Xu, Gelin, Yadgir, Simon, Yadollahpour, Ali, Jabbari, Seyed Hossein Yahyazadeh, Yakob, Bereket, Yan, Lijing L., Yano, Yuichiro, Yaseri, Mehdi, Yasin, Yasin Jemal, Yentur, Gokalp Kadri, Yeshaneh, Alex, Yimer, Ebrahim M., Yip, Paul, Yirsaw, Biruck Desalegn, Yisma, Engida, Yonemoto, Naohiro, Yonga, Gerald, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z., Yousefifard, Mahmoud, Yu, Chuanhua, Zadnik, Vesna, Zaidi, Zoubida, Bin Zaman, Sojib, Zamani, Mohammad, Zare, Zohreh, Zeleke, Ayalew Jejaw, Zenebe, Zerihun Menlkalew, Zhang, Anthony Lin, Zhang, Kai, Zhou, Maigeng, Zodpey, Sanjay, Zuhlke, Liesl Joanna, Naghavi, Ntishsen, Murray, Christopher J. 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Bensenor, Im, Berman, Ae, Bertolacci, Gj, Bhutta, Za, Biehl, Mh, Blacker, Bf, Basara, Bb, Brady, Oj, Brant, Lc, Breitborde, Njk, Butt, Za, Callender, Cskh, Campos-Nonato, Ir, Campuzano Rincon, Jc, Cárdenas, R, Carrero, Jj, Castañeda-Orjuela, Ca, Castle, Cd, Catalá-López, F, Chang, Jc, Charlson, Fj, Chiang, Pp, Chisumpa, Vh, Christopher, Dj, Chung, Sc, Cicuttini, Fm, Ciobanu, Lg, Cohen, Aj, Cooper, Lt, Cortesi, Pa, Cowie, Bc, Criqui, Mh, Cromwell, Ea, Crump, Ja, Daba, Ak, Dadi, Af, Dang, Ak, Dargan, Pi, Das, Sk, Gupta, Rd, Neves, Jd, Dasa, Tt, Dash, Ap, Davis, Ac, Davitoiu, Dv, De La Hoz, Fp, De Neve, Jw, Degefa, Mg, Degfie, Tt, Demoz, Gt, Demtsu, Bb, Denova-Gutiérrez, E, Des Jarlais, Dc, Dessie, Ga, Dharmaratne, Sd, Dinberu, Mt, Ding, El, Dirac, Ma, Doku, Dt, Donnelly, Ca, Dorsey, Er, Doshi, Pp, Doyle, Ke, Driscoll, Tr, Duken, Ee, Duncan, Bb, Duraes, Ar, Eggen, Ae, Ellingsen, Cl, Endries, Ay, Erskine, He, Farinha, Cse, Farzaei, Mh, Feigin, Vl, Feigl, Ab, Fereshtehnejad, Sm, Fernandes, Jc, Ferrari, Aj, Feyissa, Gt, Foigt, Na, Foreman, Kj, Frank, Td, Fuller, Je, Fürst, T, Furtado, Jm, Futran, Nd, Garcia-Basteiro, Al, Garcia-Gordillo, Ma, Gardner, Wm, Gebre, Ak, Gebrehiwot, Tt, Gebremedhin, At, Gebremichael, Tg, Gelano, Tf, Geleijnse, Jm, Geramo, Ycd, Gething, Pw, Gezae, Ke, Ghadami, Mr, Gibney, Kb, Gill, Tk, Gillum, Rf, Ginawi, Ia, Goldberg, Em, Gómez-Dantés, H, Gona, Pn, Gopalani, Sv, Gorman, Tm, Goulart, Ac, Gnedovskaya, Ev, Gugnani, Hc, Guimaraes, Al, Gupta, Pc, Gutiérrez, Ra, Haagsma, Ja, Hagos, Tb, Hailegiyorgis, Tt, Hailu, Gb, Hamadeh, Rr, Handal, Aj, Hankey, Gj, Harb, Hl, Haro, Jm, Hassen, Hy, Hay, Rj, Hay, Si, Hegazy, Mi, Henry, Nj, Hibstu, Dt, Hoek, Hw, Hole, Mk, Hosgood, Hd, Hosseini, Sm, Hotez, Pj, Hoy, Dg, Huang, Jj, Hussen, Mm, Irvani, Ssn, Irvine, Cm, Islam, Sm, Jacobsen, Kh, Jain, Sk, Jalu, Mt, James, Sl, Jayatilleke, Au, Jenkins, Kj, Jha, Rp, Johnson, Co, Johnson, Sc, Jonas, Jb, Jozwiak, Jj, Jungari, Sb, Jürisson, M, Kassa, Dh, Kassa, Gm, Kassa, Td, Kassebaum, Nj, Katikireddi, Sv, Karyani, Ak, Kefale, At, Keiyoro, Pn, Kemp, Gr, Kengne, Ap, Kesavachandran, Cn, Khafaie, Ma, Khalil, Ia, Khan, Ea, Khan, Ma, Khang, Yh, Khater, Mm, Khoja, At, Khosravi, Mh, Kiadaliri, Aa, Kibret, Gd, Kidanemariam, Zt, Kiirithio, Dn, Kim, Ye, Kim, Yj, Kimokoti, Rw, Kivimäki, M, Knudsen, Ak, Kocarnik, Jm, Kopec, Ja, Koul, Pa, Kravchenko, Ma, Kumar, Ga, Kutz, Mj, Kyu, Hh, Lad, Dp, Lad, Sd, Lal, Dk, Lam, Jo, Lami, Fh, Lansingh, Vc, Larson, Hj, Lau, Km, Lazarus, Jv, Lee, Ph, Leshargie, Ct, Lim, Ll, Limenih, Ma, Lopez, Ad, Lotufo, Pa, Macarayan, Erk, Mackay, Mt, Maclachlan, Jh, Maddison, Er, Maghavani, Dp, Malta, Dc, Manda, Al, Mandarano-Filho, Lg, Mansournia, Ma, Mapoma, Cc, Maravilla, Jc, Marks, Gb, Martins-Melo, Fr, März, W, Marzan, Mb, Masci, Jr, Massenburg, Bb, Mathur, Mr, Maulik, Pk, Mcgrath, Jj, Mcmahon, Bj, Mehndiratta, Mm, Mehta, Km, Mekonnen, Tc, Memiah, Ptn, Memish, Za, Mengistu, Dt, Mensah, Ga, Mereta, St, Meretoja, Tj, Mezgebe, Hb, Millear, Ai, 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Reiner, Rc, Reitsma, Mb, Renzaho, Amn, Riahi, Sm, Ribeiro, Alp, Rios-Blancas, Mj, Roba, Kt, Roberts, Nl, Robinson, Sr, Sahraian, Ma, Saldanha, Rf, Sambala, Ez, Samy, Am, Sanchez-Niño, Md, Santomauro, Df, Santos, Jv, Milicevic, Mm, Sao Jose, Bp, Sarker, Ar, Sarmiento-Suárez, R, Sawant, Ar, Schmidt, Mi, Schneider, Ijc, Schöttker, B, Schutte, Ae, Schwebel, Dc, Scott, Jg, Sepanlou, Sg, Serván-Mori, E, Shackelford, Ka, Shaheen, Aa, Shaikh, Ma, Shrime, Mg, Siddiqi, Tj, Sigfusdottir, Id, Silberberg, Dh, Silva, Da, Silva, Jp, Silva, Ntd, Silveira, Dga, Singh, Ja, Singh, Np, Singh, Pk, Sinha, Dn, Sobaih, Bh, Sorensen, Rjd, Soriano, Jb, Soyiri, In, Sposato, La, Sreeramareddy, Ct, Stanaway, Jd, Starodubov, Vi, Stein, Dj, Stewart, Lg, Stokes, Ma, Subart, Ml, Sufiyan, Mb, Sur, Pj, Sykes, Bl, Sylaja, Pn, Sylte, Do, Szoeke, Cei, Tabarés-Seisdedos, R, Tadakamadla, Sk, Tassew, Sg, Tekalign, Tg, Tekle, Mg, Temsah, Mh, Teshale, My, Tessema, Ga, Thankappan, Kr, Thrift, Ag, Thurston, Gd, To, Qg, Torre, Ae, Tortajada-Girbés, M, Tovani-Palone, Mr, Tran, Bx, Tran, Kb, Troeger, Ce, Truelsen, Tc, Truong, Nt, Tsadik, Ag, Tuzcu, Em, Ukwaja, Kn, Undurraga, Ea, Updike, Rl, Uthman, Oa, Uzun, Sb, Valdez, Pr, Vasankari, Tj, Vladimirov, Sk, Vollset, Se, Wagner, Gr, Wallin, Mt, Walson, Jl, Wang, Yp, Wassie, Mm, Weintraub, Rg, Weldegwergs, Kg, Werkneh, Aa, West, Te, Whiteford, Ha, Wilner, Lb, Wolfe, Cda, Wu, Yc, Wyper, Gma, Yahyazadeh Jabbari, Sh, Yan, Ll, Yasin, Yj, Yentür, Gk, Yimer, Em, Yirsaw, Bd, Yoon, Sj, Younis, Mz, Zaman, Sb, Zeleke, Aj, Zenebe, Zm, Zhang, Al, Zuhlke, Lj, and Murray, Cjl.
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Adult ,Male ,Adolescent ,national age-sex-specific mortality ,UNITED-STATES ,Global Health ,Socioeconomic Factor ,Global Burden of Disease ,GBD, causes of death ,Young Adult ,Age Distribution ,Life Expectancy ,General & Internal Medicine ,Cause of Death ,PUBLIC-HEALTH PROBLEM ,mortality ,282 causes global burden of disease ,Sex Distribution ,Child ,Aged ,Aged, 80 and over ,BARRIERS ,DEMENTIA ,Medicine (all) ,Infant, Newborn ,Infant ,11 Medical And Health Sciences ,Middle Aged ,TRENDS ,PREVENTION ,PREVALENCE ,ALZHEIMERS-DISEASE ,INDIVIDUALS ,3121 General medicine, internal medicine and other clinical medicine ,Child, Preschool ,REGISTRATION ,Female ,Human medicine ,Human - Abstract
Background Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. GBD 2017 provides a comprehensive assessment of cause-specific mortality for 282 causes in 195 countries and territories from 1980 to 2017. Methods The causes of death database is composed of vital registration (VR), verbal autopsy (VA), registry, survey, police, and surveillance data. GBD 2017 added ten VA studies, 127 country-years of VR data, 502 cancer-registry country-years, and an additional surveillance country-year. Expansions of the GBD cause of death hierarchy resulted in 18 additional causes estimated for GBD 2017. Newly available data led to subnational estimates for five additional countries Ethiopia, Iran, New Zealand, Norway, and Russia. Deaths assigned International Classification of Diseases (ICD) codes for non-specific, implausible, or intermediate causes of death were reassigned to underlying causes by redistribution algorithms that were incorporated into uncertainty estimation. We used statistical modelling tools developed for GBD, including the Cause of Death Ensemble model (CODErn), to generate cause fractions and cause specific death rates for each location, year, age, and sex. Instead of using UN estimates as in previous versions, GBD 2017 independently estimated population size and fertility rate for all locations. Years of life lost (YLLs) were then calculated as the sum of each death multiplied by the standard life expectancy at each age. All rates reported here are age-standardised. Findings At the broadest grouping of causes of death (Level 1), non-communicable diseases (NC Ds) comprised the greatest fraction of deaths, contributing to 73.4% (95% uncertainty interval [UI] 72.5-74.1) of total deaths in 2017, while communicable, maternal, neonatal, and nutritional (CMNN) causes accounted for 186% (17.9-19.6), and injuries 8.0% (7.7-8.2). Total numbers of deaths from NCD causes increased from 2007 to 2017 by 22.7% (21.5-23.9), representing an additional 7.61 million (7. 20-8.01) deaths estimated in 2017 versus 2007. The death rate from NCDs decreased globally by 7.9% (7.08.8). The number of deaths for CMNN causes decreased by 222% (20.0-24.0) and the death rate by 31.8% (30.1-33.3). Total deaths from injuries increased by 2.3% (0-5-4-0) between 2007 and 2017, and the death rate from injuries decreased by 13.7% (12.2-15.1) to 57.9 deaths (55.9-59.2) per 100 000 in 2017. Deaths from substance use disorders also increased, rising from 284 000 deaths (268 000-289 000) globally in 2007 to 352 000 (334 000-363 000) in 2017. Between 2007 and 2017, total deaths from conflict and terrorism increased by 118.0% (88.8-148.6). A greater reduction in total deaths and death rates was observed for some CMNN causes among children younger than 5 years than for older adults, such as a 36.4% (32.2-40.6) reduction in deaths from lower respiratory infections for children younger than 5 years compared with a 33.6% (31.2-36.1) increase in adults older than 70 years. Globally, the number of deaths was greater for men than for women at most ages in 2017, except at ages older than 85 years. Trends in global YLLs reflect an epidemiological transition, with decreases in total YLLs from enteric infections, respirator}, infections and tuberculosis, and maternal and neonatal disorders between 1990 and 2017; these were generally greater in magnitude at the lowest levels of the Socio-demographic Index (SDI). At the same time, there were large increases in YLLs from neoplasms and cardiovascular diseases. YLL rates decreased across the five leading Level 2 causes in all SDI quintiles. The leading causes of YLLs in 1990 neonatal disorders, lower respiratory infections, and diarrhoeal diseases were ranked second, fourth, and fifth, in 2017. Meanwhile, estimated YLLs increased for ischaemic heart disease (ranked first in 2017) and stroke (ranked third), even though YLL rates decreased. Population growth contributed to increased total deaths across the 20 leading Level 2 causes of mortality between 2007 and 2017. Decreases in the cause-specific mortality rate reduced the effect of population growth for all but three causes: substance use disorders, neurological disorders, and skin and subcutaneous diseases. Interpretation Improvements in global health have been unevenly distributed among populations. Deaths due to injuries, substance use disorders, armed conflict and terrorism, neoplasms, and cardiovascular disease are expanding threats to global health. For causes of death such as lower respiratory and enteric infections, more rapid progress occurred for children than for the oldest adults, and there is continuing disparity in mortality rates by sex across age groups. Reductions in the death rate of some common diseases are themselves slowing or have ceased, primarily for NCDs, and the death rate for selected causes has increased in the past decade. Copyright (C) 2018 The Author(s). Published by Elsevier Ltd.
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103. FLUID ORIGIN AND DYNAMIC AT THE NEWLY DEVELOPED THEISTAREYKIR GEOTHERMAL FIELD, ICELAND
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Saby, Marion, Pinti, Daniele, Hinsbger, Vincent Van, Gautason, Bjarni, Sigurðardóttir, Ásgerður, Castro, Clara, Hall, Chris, Jean-François Hélie, and Rocher, Océane
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geothermal field ,water isotopes ,Noble gas isotopes ,Iceland ,Theistareykir - Abstract
This study aim at deciphering the origin of the fluids and the hydrodynamic of the Theistareykir geothermal system using water isotopes and noble gases as a tracer of these respective contributions. Results first confirm that the magma beneath Theistareykir is a mix between a mantle plume (OIB) and an ocean ridge basalt (MORB). They also show that both magmatic fluids and surface water are present in the system in proportions that are being quantifyed. Water isotopes show that sources of surface water range from modern to Pre-Holocene. A crustal input is also present in the system with an enrichment in δ18O highlighting water-rock interaction.
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- 2019
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104. Global, regional, and national cancer incidence, mortality, years of life lost, years lived with disability, and disability-adjusted life-years for 29 cancer groups, 1990 to 2017
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Fitzmaurice, Christina, Abate, Degu, Abbasi, Naghmeh, Abbastabar, Hedayat, Abd-Allah, Foad, Abdel-Rahman, Omar, Abdelalim, Ahmed, Abdoli, Amir, Abdollahpour, Ibrahim, Abdulle, Abdishakur SM, Abebe, Nebiyu Dereje, Abraha, Haftom Niguse, Abu-Raddad, Laith Jamal, Abualhasan, Ahmed, Adedeji, Isaac Akinkunmi, Advani, Shailesh M, Afarideh, Mohsen, Afshari, Mahdi, Aghaali, Mohammad, Agius, Dominic, Agrawal, Sutapa, Ahmadi, Ayat, Ahmadian, Elham, Ahmadpour, Ehsan, Ahmed, Muktar Beshir, Akbari, Mohammad Esmaeil, Akinyemiju, Tomi, Al-Aly, Ziyad, AlAbdulKader, Assim M, Alahdab, Fares, Alam, Tahiya, Alamene, Genet Melak, Alemnew, Birhan Tamene T, Alene, Kefyalew Addis, Alinia, Cyrus, Alipour, Vahid, Aljunid, Syed Mohamed, Bakeshei, Fatemeh Allah, Almadi, Majid Abdulrahman Hamad, Almasi-Hashiani, Amir, Alsharif, Ubai, Alsowaidi, Shirina, Alvis-Guzman, Nelson, Amini, Erfan, Amini, Saeed, Amoako, Yaw Ampem, Anbari, Zohreh, Anber, Nahla Hamed, Andrei, Catalina Liliana, Anjomshoa, Mina, Ansari, Fereshteh, Ansariadi, Ansariadi, Appiah, Seth Christopher Yaw, Arab-Zozani, Morteza, Arabloo, Jalal, Arefi, Zohreh, Aremu, Olatunde, Areri, Habtamu Abera, Artaman, Al, Asayesh, Hamid, Asfaw, Ephrem Tsegay, Ashagre, Alebachew Fasil, Assadi, Reza, Ataeinia, Bahar, Atalay, Hagos Tasew, Ataro, Zerihun, Atique, Suleman, Ausloos, Marcel, Avila-Burgos, Leticia, Avokpaho, Euripide FGA, Awasthi, Ashish, Awoke, Nefsu, Ayala Quintanilla, Beatriz Paulina, Ayanore, Martin Amogre, Ayele, Henok Tadesse, Babaee, Ebrahim, Bacha, Umar, Badawi, Alaa, Bagherzadeh, Mojtaba, Bagli, Eleni, Balakrishnan, Senthilkuimar, Balouchi, Abbas, Bärnighausen, Till Winfried, Battista, Robert J, Behzadifar, Masoud, Behzadifar, Meysam, Bekele, Bayu Begashaw, Belay, Yared Belete, Belayneh, Yaschilal Muche, Berfield, Kathleen Kim Sachiko, Berhane, Adugnaw, Bernabe, Eduardo, Beuran, Mircea, Bhakta, Nickhill, Bhattacharyya, Krittika, Biadgo, Belete, Bijani, Ali, Bin Sayeed, Muhammad Shahdaat, Birungi, Charles, Bisignano, Catherine, Bitew, Helen, Bjørge, Tone, Bleyer, Archie, Bogale, Kassawmar Angaw, Bojia, Hunduma Amensisa, Borzì, Antonio M, Bosetti, Cristina, Bou-Orm, Ibrahim R, Brenner, Hermann, Brewer, Jerry D, Briko, Andrey Nikolaevich, Briko, Nikolay Ivanovich, Bustamante-Teixeira, Maria Teresa, Butt, Zahid A, Carreras, Giulia, Carrero, Juan J, Carvalho, Félix, Castro, Clara, Castro, Franz, Catalá-López, Ferrán, Cerin, Ester, Chaiah, Yazan, Chanie, Wagaye Fentahun, Chattu, Vijay Kumar, Chaturvedi, Pankaj, Chauhan, Neelima Singh, Chehrazi, Mohammad, Chiang, Peggy Pei-Chia, Chichiabellu, Tesfaye Yitna, Chido-Amajuoyi, Onyema Greg, Chimed-Ochir, Odgerel, Choi, Jee-Young J, Christopher, Devasahayam J, Chu, Dinh-Toi, Constantin, Maria-Magdalena, Costa, Vera M, Crocetti, Emanuele, Crowe, Christopher Stephen, Curado, Maria Paula, Dahlawi, Saad MA, Damiani, Giovanni, Darwish, Amira Hamed, Daryani, Ahmad, das Neves, José, Demeke, Feleke Mekonnen, Demis, Asmamaw Bizuneh, Demissie, Birhanu Wondimeneh, Demoz, Gebre Teklemariam, Denova-Gutiérrez, Edgar, Derakhshani, Afshin, Deribe, Kalkidan Solomon, Desai, Rupak, Desalegn, Beruk Berhanu, Desta, Melaku, Dey, Subhojit, Dharmaratne, Samath Dhamminda, Dhimal, Meghnath, Diaz, Daniel, Dinberu, Mesfin Tadese Tadese, Djalalinia, Shirin, Doku, David Teye, Drake, Thomas M, Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Ebrahimi, Hedyeh, Effiong, Andem, Eftekhari, Aziz, El Sayed, Iman, Zaki, Maysaa El Sayed, El-Jaafary, Shaimaa I, El-Khatib, Ziad, Elemineh, Demelash Abewa, Elkout, Hajer, Ellenbogen, Richard G, Elsharkawy, Aisha, Emamian, Mohammad Hassan, Endalew, Daniel Adane, Endries, Aman Yesuf, Eshrati, Babak, Fadhil, Ibtihal, Fallah, Vahid, Faramarzi, Mahbobeh, Farhangi, Mahdieh Abbasalizad, Farioli, Andrea, Farzadfar, Farshad, Fentahun, Netsanet, Fernandes, Eduarda, Feyissa, Garumma Tolu, Filip, Irina, Fischer, Florian, Fisher, James L, Force, Lisa M, Foroutan, Masoud, Freitas, Marisa, Fukumoto, Takeshi, Futran, Neal D, Gallus, Silvano, Gankpe, Fortune Gbetoho, Gayesa, Reta Tsegaye, Gebrehiwot, Tsegaye Tewelde, Gebremeskel, Gebreamlak Gebremedhn, Gedefaw, Getnet Azeze, Gelaw, Belayneh K, Geta, Birhanu, Getachew, Sefonias, Gezae, Kebede Embaye, Ghafourifard, Mansour, Ghajar, Alireza, Ghashghaee, Ahmad, Gholamian, Asadollah, Gill, Paramjit Singh, Ginindza, Themba TG, Girmay, Alem, Gizaw, Muluken, Gomez, Ricardo Santiago, Gopalani, Sameer Vali, Gorini, Giuseppe, Goulart, Bárbara Niegia Garcia, Grada, Ayman, Ribeiro Guerra, Maximiliano, Guimaraes, Andre Luiz Sena, Gupta, Prakash C, Gupta, Rahul, Hadkhale, Kishor, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamadeh, Randah R, Hamidi, Samer, Hanfore, Lolemo Kelbiso, Haro, Josep Maria, Hasankhani, Milad, Hasanzadeh, Amir, Hassen, Hamid Yimam, Hay, Roderick J, Hay, Simon I, Henok, Andualem, Henry, Nathaniel J, Herteliu, Claudiu, Hidru, Hagos D, Hoang, Chi Linh, Hole, Michael K, Hoogar, Praveen, Horita, Nobuyuki, Hosgood, H Dean, Hosseini, Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Househ, Mowafa, Hussen, Mohammedaman Mama, Ileanu, Bogdan, Ilic, Milena D, Innos, Kaire, Irvani, Seyed Sina Naghibi, Iseh, Kufre Robert, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Jafari Balalami, Nader, Jafarinia, Morteza, Jahangiry, Leila, Jahani, Mohammad Ali, Jahanmehr, Nader, Jakovljevic, Mihajlo, James, Spencer L, Javanbakht, Mehdi, Jayaraman, Sudha, Jee, Sun Ha, Jenabi, Ensiyeh, Jha, Ravi Prakash, Jonas, Jost B, Jonnagaddala, Jitendra, Joo, Tamas, Jungari, Suresh Banayya, Jürisson, Mikk, Kabir, Ali, Kamangar, Farin, Karch, André, Karimi, Narges, Karimian, Ansar, Kasaeian, Amir, Kasahun, Gebremicheal Gebreslassie, Kassa, Belete, Kassa, Tesfaye Dessale, Kassaw, Mesfin Wudu, Kaul, Anil, Keiyoro, Peter Njenga, Kelbore, Abraham Getachew, Kerbo, Amene Abebe, Khader, Yousef Saleh, Khalilarjmandi, Maryam, Khan, Ejaz Ahmad, Khan, Gulfaraz, Khang, Young-Ho, Khatab, Khaled, Khater, Amir, Khayamzadeh, Maryam, Khazaee-Pool, Maryam, Khazaei, Salman, Khoja, Abdullah T, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kianipour, Neda, Kim, Daniel, Kim, Yun Jin, Kisa, Adnan, Kisa, Sezer, Kissimova-Skarbek, Katarzyna, Komaki, Hamidreza, Koyanagi, Ai, Krohn, Kristopher J, Bicer, Burcu Kucuk, Kugbey, Nuworza, Kumar, Vivek, Kuupiel, Desmond, La Vecchia, Carlo, Lad, Deepesh P, Lake, Eyasu Alem, Lakew, Ayenew Molla, Lal, Dharmesh Kumar, Lami, Faris Hasan, Lan, Qing, Lasrado, Savita, Lauriola, Paolo, Lazarus, Jeffrey V, Leigh, James, Leshargie, Cheru Tesema, Liao, Yu, Limenih, Miteku Andualem, Listl, Stefan, Lopez, Alan D, Lopukhov, Platon D, Lunevicius, Raimundas, Madadin, Mohammed, Magdeldin, Sameh, El Razek, Hassan Magdy Abd, Majeed, Azeem, Maleki, Afshin, Malekzadeh, Reza, Manafi, Ali, Manafi, Navid, Manamo, Wondimu Ayele, Mansourian, Morteza, Mansournia, Mohammad Ali, Mantovani, Lorenzo Giovanni, Maroufizadeh, Saman, Martini, Santi Martini S, Mashamba-Thompson, Tivani Phosa, Massenburg, Benjamin Ballard, Maswabi, Motswadi Titus, Mathur, Manu Raj, McAlinden, Colm, McKee, Martin, Meheretu, Hailemariam Abiy Alemu, Mehrotra, Ravi, Mehta, Varshil, Meier, Toni, Melaku, Yohannes A, Meles, Gebrekiros Gebremichael, Meles, Hagazi Gebre, Melese, Addisu, Melku, Mulugeta, Memiah, Peter TN, Mendoza, Walter, Menezes, Ritesh G, Merat, Shahin, Meretoja, Tuomo J, Mestrovic, Tomislav, Miazgowski, Bartosz, Miazgowski, Tomasz, Mihretie, Kebadnew Mulatu M, Miller, Ted R, Mills, Edward J, Mir, Seyed Mostafa, Mirzaei, Hamed, Mirzaei, Hamid Reza, Mishra, Rashmi, Moazen, Babak, Mohammad, Dara K, Mohammad, Karzan Abdulmuhsin, Mohammad, Yousef, Darwesh, Aso Mohammad, Mohammadbeigi, Abolfazl, Mohammadi, Hiwa, Mohammadi, Moslem, Mohammadian, Mahdi, Mohammadian-Hafshejani, Abdollah, Mohammadoo-Khorasani, Milad, Mohammadpourhodki, Reza, Mohammed, Ammas Siraj, Mohammed, Jemal Abdu, Mohammed, Shafiu, Mohebi, Farnam, Mokdad, Ali H, Monasta, Lorenzo, Moodley, Yoshan, Moosazadeh, Mahmood, Moossavi, Maryam, Moradi, Ghobad, Moradi-Joo, Mohammad, Moradi-Lakeh, Maziar, Moradpour, Farhad, Morawska, Lidia, Morgado-da-Costa, Joana, Morisaki, Naho, Morrison, Shane Douglas, Mosapour, Abbas, Mousavi, Seyyed Meysam, Muche, Achenef Asmamaw, Muhammed, Oumer Sada S, Musa, Jonah, Nabhan, Ashraf R, Naderi, Mehdi, Nagarajan, Ahamarshan Jayaraman, Nagel, Gabriele, Nahvijou, Azin, Naik, Gurudatta, Najafi, Farid, Naldi, Luigi, Nam, Hae Sung, Nasiri, Naser, Nazari, Javad, Negoi, Ionut, Neupane, Subas, Newcomb, Polly A, Nggada, Haruna Asura, Ngunjiri, Josephine W, Nguyen, Cuong Tat, Nikniaz, Leila, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Nixon, Molly R, Nnaji, Chukwudi A, Nojomi, Marzieh, Nosratnejad, Shirin, Shiadeh, Malihe Nourollahpour, Obsa, Mohammed Suleiman, Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Oh, In-Hwan, Olagunju, Andrew T, Olagunju, Tinuke O, Oluwasanu, Mojisola Morenike, Omonisi, Abidemi E, Onwujekwe, Obinna E, Oommen, Anu Mary, Oren, Eyal, Ortega-Altamirano, Doris DV, Ota, Erika, Otstavnov, Stanislav S, Owolabi, Mayowa Ojo, P A, Mahesh, Padubidri, Jagadish Rao, Pakhale, Smita, Pakpour, Amir H, Pana, Adrian, Park, Eun-Kee, Parsian, Hadi, Pashaei, Tahereh, Patel, Shanti, Patil, Snehal T, Pennini, Alyssa, Pereira, David M, Piccinelli, Cristiano, Pillay, Julian David, Pirestani, Majid, Pishgar, Farhad, Postma, Maarten J, Pourjafar, Hadi, Pourmalek, Farshad, Pourshams, Akram, Prakash, Swayam, Prasad, Narayan, Qorbani, Mostafa, Rabiee, Mohammad, Rabiee, Navid, Radfar, Amir, Rafiei, Alireza, Rahim, Fakher, Rahimi, Mahdi, Rahman, Muhammad Aziz, Rajati, Fatemeh, Rana, Saleem M, Raoofi, Samira, Rath, Goura Kishor, Rawaf, David Laith, Rawaf, Salman, Reiner, Robert C, Renzaho, Andre MN, Rezaei, Nima, Rezapour, Aziz, Ribeiro, Ana Isabel, Ribeiro, Daniela, Ronfani, Luca, Roro, Elias Merdassa, Roshandel, Gholamreza, Rostami, Ali, Saad, Ragy Safwat, Sabbagh, Parisa, Sabour, Siamak, Saddik, Basema, Safiri, Saeid, Sahebkar, Amirhossein, Salahshoor, Mohammad Reza, Salehi, Farkhonde, Salem, Hosni, Salem, Marwa Rashad, Salimzadeh, Hamideh, Salomon, Joshua A, Samy, Abdallah M, Sanabria, Juan, Santric Milicevic, Milena M, Sartorius, Benn, Sarveazad, Arash, Sathian, Brijesh, Satpathy, Maheswar, Savic, Miloje, Sawhney, Monika, Sayyah, Mehdi, Schneider, Ione JC, Schöttker, Ben, Sekerija, Mario, Sepanlou, Sadaf G, Sepehrimanesh, Masood, Seyedmousavi, Seyedmojtaba, Shaahmadi, Faramarz, Shabaninejad, Hosein, Shahbaz, Mohammad, Shaikh, Masood Ali, Shamshirian, Amir, Shamsizadeh, Morteza, Sharafi, Heidar, Sharafi, Zeinab, Sharif, Mehdi, Sharifi, Ali, Sharifi, Hamid, Sharma, Rajesh, Sheikh, Aziz, Shirkoohi, Reza, Shukla, Sharvari Rahul, Si, Si, Siabani, Soraya, Silva, Diego Augusto Santos, Silveira, Dayane Gabriele Alves, Singh, Ambrish, Singh, Jasvinder A, Sisay, Solomon, Sitas, Freddy, Sobngwi, Eugène, Soofi, Moslem, Soriano, Joan B, Stathopoulou, Vasiliki, Sufiyan, Mu’awiyyah Babale, Tabarés-Seisdedos, Rafael, Tabuchi, Takahiro, Takahashi, Ken, Tamtaji, Omid Reza, Tarawneh, Mohammed Rasoul, Tassew, Segen Gebremeskel, Taymoori, Parvaneh, Tehrani-Banihashemi, Arash, Temsah, Mohamad-Hani, Temsah, Omar, Tesfay, Berhe Etsay, Tesfay, Fisaha Haile, Teshale, Manaye Yihune, Tessema, Gizachew Assefa, Thapa, Subash, Tlaye, Kenean Getaneh, Topor-Madry, Roman, Tovani-Palone, Marcos Roberto, Traini, Eugenio, Tran, Bach Xuan, Tran, Khanh Bao, Tsadik, Afewerki Gebremeskel, Ullah, Irfan, Uthman, Olalekan A, Vacante, Marco, Vaezi, Maryam, Varona Pérez, Patricia, Veisani, Yousef, Vidale, Simone, Violante, Francesco S, Vlassov, Vasily, Vollset, Stein Emil, Vos, Theo, Vosoughi, Kia, Vu, Giang Thu, Vujcic, Isidora S, Wabinga, Henry, Wachamo, Tesfahun Mulatu, Wagnew, Fasil Shiferaw, Waheed, Yasir, Weldegebreal, Fitsum, Weldesamuel, Girmay Teklay, Wijeratne, Tissa, Wondafrash, Dawit Zewdu, Wonde, Tewodros Eshete, Wondmieneh, Adam Belay, Workie, Hailemariam Mekonnen, Yadav, Rajaram, Yadegar, Abbas, Yadollahpour, Ali, Yaseri, Mehdi, Yazdi-Feyzabadi, Vahid, Yeshaneh, Alex, Yimam, Mohammed Ahmed, Yimer, Ebrahim M, Yisma, Engida, Yonemoto, Naohiro, Younis, Mustafa Z, Yousefi, Bahman, Yousefifard, Mahmoud, Yu, Chuanhua, Zabeh, Erfan, Zadnik, Vesna, Moghadam, Telma Zahirian, Zaidi, Zoubida, Zamani, Mohammad, Zandian, Hamed, Zangeneh, Alireza, Zaki, Leila, Zendehdel, Kazem, Zenebe, Zerihun Menlkalew, Zewale, Taye Abuhay, Ziapour, Arash, Zodpey, Sanjay, and Murray, Christopher JL
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Global Burden of Disease Cancer Collaboration - Abstract
Importance Cancer and other noncommunicable diseases (NCDs) are now widely recognized as a threat to global development. The latest United Nations high-level meeting on NCDs reaffirmed this observation and also highlighted the slow progress in meeting the 2011 Political Declaration on the Prevention and Control of Noncommunicable Diseases and the third Sustainable Development Goal. Lack of situational analyses, priority setting, and budgeting have been identified as major obstacles in achieving these goals. All of these have in common that they require information on the local cancer epidemiology. The Global Burden of Disease (GBD) study is uniquely poised to provide these crucial data.\ud \ud Objective To describe cancer burden for 29 cancer groups in 195 countries from 1990 through 2017 to provide data needed for cancer control planning.\ud \ud Evidence Review We used the GBD study estimation methods to describe cancer incidence, mortality, years lived with disability, years of life lost, and disability-adjusted life-years (DALYs). Results are presented at the national level as well as by Socio-demographic Index (SDI), a composite indicator of income, educational attainment, and total fertility rate. We also analyzed the influence of the epidemiological vs the demographic transition on cancer incidence.\ud \ud Findings In 2017, there were 24.5 million incident cancer cases worldwide (16.8 million without nonmelanoma skin cancer [NMSC]) and 9.6 million cancer deaths. The majority of cancer DALYs came from years of life lost (97%), and only 3% came from years lived with disability. The odds of developing cancer were the lowest in the low SDI quintile (1 in 7) and the highest in the high SDI quintile (1 in 2) for both sexes. In 2017, the most common incident cancers in men were NMSC (4.3 million incident cases); tracheal, bronchus, and lung (TBL) cancer (1.5 million incident cases); and prostate cancer (1.3 million incident cases). The most common causes of cancer deaths and DALYs for men were TBL cancer (1.3 million deaths and 28.4 million DALYs), liver cancer (572 000 deaths and 15.2 million DALYs), and stomach cancer (542 000 deaths and 12.2 million DALYs). For women in 2017, the most common incident cancers were NMSC (3.3 million incident cases), breast cancer (1.9 million incident cases), and colorectal cancer (819 000 incident cases). The leading causes of cancer deaths and DALYs for women were breast cancer (601 000 deaths and 17.4 million DALYs), TBL cancer (596 000 deaths and 12.6 million DALYs), and colorectal cancer (414 000 deaths and 8.3 million DALYs).\ud \ud Conclusions and Relevance The national epidemiological profiles of cancer burden in the GBD study show large heterogeneities, which are a reflection of different exposures to risk factors, economic settings, lifestyles, and access to care and screening. The GBD study can be used by policy makers and other stakeholders to develop and improve national and local cancer control in order to achieve the global targets and improve equity in cancer
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- 2019
105. Not the usual suspects: membrane translocation, pathogenic potential and bacterial species of the Acinetobacter baumannii group
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Cosgaya Castro, Clara, Vila Estapé, Jordi, Roca Subirà, Ignasi, and Universitat de Barcelona. Departament de Fonaments Clínics
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Taxonomia (Biologia) ,Biología molecular ,Bacteria ,Molecular biology ,Resistencia a los medicamentos ,Ciències de la Salut ,Bacteris ,Diagnòstic microbiològic ,Taxonomy (Biology) ,Drug resistance ,Taxonomía (Biología) ,Diagnóstico microbiológico ,Diagnostic microbiology ,Bacterias ,Resistència als medicaments ,Biologia molecular - Abstract
[eng] The most clinically relevant species of the Acinetobacter genus are comprised within the Acinetobacter baumannii group (Ab group, i. e. A. baumannii, Acinetobacter nosocomialis, Acinetobacter pittii, Acinetobacter seifertii and A. pittii-like/A. dijskhoorniae). Among these species A. baumannii is the most prevalent and usually shows multidrug resistance. This, and the fact that the Ab group species cannot be distinguished by phenotypic methods, has led to the misidentification of the species of the Ab group as A. baumannii in the clinical settings. Nevertheless, in the last years the incidence of the other species of the Ab group has risen, partly due to the use of molecular techniques and mass spectrometry tools. This thesis has characterised, using both genotypic (rpoB-based and MLSA phylogenetic analyses, and whole genome sequence analysis) and phenotypic (carbon utilisation assays and MALDI-TOF MS) techniques, a group of strains mainly recovered from human samples that represents a new bacterial species within the Ab group for which the name of Acinetobacter dijkshoorniae has been proposed. The genome of the type strain of the novel species has been sequenced and the identification of the species of the Ab group by MALDI-TOF MS has been optimised, since the novel species (A. dijkshoorniae and A. seifertii) could not be identified by this technique prior to this study. MALDI-TOF MS was shown to be rapid and accurate in the discrimination of all the species of the Ab group, indicating its suitability for the implementation of this technique in the clinical settings. In addition, the use of MALDI- TOF MS allowed the identification of members of the Ab group in market meat from Peru, leading to the first identification of A. dijkshoorniae from food and in South America. We also evaluated the differences among the species of the Ab group beyond those at the taxonomic level and found that while A. baumannii still presents the higher rates of antimicrobial resistance, this species and A. nosocomialis, which usually are more prevalent in our hospitals and have worst outcomes, showed a minor pathogenicity in terms of biofilm formation and virulence in the Caenorhabditis elegans infection model. In contrast, A. pittii, A. seifertii and A. dijkshoorniae presented a higher pathogenicity in the phenotypes studied. This data suggests the emergence of the non-baumannii species of the Ab group as well as different degrees of adaptation to the human host and the need of studying them as distinct entities. The rise on the antimicrobial resistance of A. baumannii has drastically reduced the therapeutic options left to treat infections caused by this pathogen. In view of the lack of effective antimicrobial drugs there is an urgent need for novel therapeutic approaches. In order to find novel targets for the development of antimicrobial drugs against A. baumannii, we evaluated the dual role of transport-related proteins in antimicrobial resistance and virulence using a transposon mutant strain collection derived from the A. baumannii AB5075 strain. The antimicrobial susceptibility of the mutant strains was compared against the wild- type strain and led to the identification of novel antimicrobial substrates for known efflux pumps and uncharacterised transport-related proteins which seem to participate in the transport of antibiotics across membranes. The evaluation of the virulence in the Galleria mellonella infection model also identified transport-related proteins putatively involved in the virulence of A. baumannii. This results are still preliminary but show the dual role of transport- related proteins in the antimicrobial resistance and pathogenicity of A. baumannii and open a new line of research that might help to gain further knowledge about the virulence of this pathogen while finding novel targets for the development of new antimicrobial drugs against A. baumannii., [spa] Dentro del género Acinetobacter, las especies del grupo Acinetobacter baumannii (Ab) (i. e. A. baumannii, Acinetobacter nosocomialis, Acinetobacter pittii y Acinetobacter seifertii y A. pittii-like/A. dijskhoorniae) destacan por su gran relevancia clínica, siendo A. baumannii el patógeno del grupo Ab de mayor importancia debido a su frecuente aislamiento y su usual fenotipo de multirresistencia. Esto, sumado a que las especies del grupo Ab son indistinguibles a nivel fenotípico, ha conllevado que habitualmente hayan sido erróneamente identificadas en el ámbito clínico como A. baumannii. Sin embargo, en los últimos años se ha observado un aumento en la incidencia de las otras especies del grupo Ab, en parte gracias a las técnicas moleculares, que han revolucionado la taxonomía de este género, y también al uso de la espectrometría de masas MALDI-ToF (EM MALDI-TOF). Este estudio proporciona las pruebas fenotípicas y genotípicas que respaldan la delineación de una nueva especie dentro del grupo Ab, para la cual se ha propuesto el nombre de Acinetobacter dijkshoorniae. El genoma de la cepa tipo de esta nueva especie ha sido secuenciado, y se ha puesto a punto la identificación mediante EM MALDI-TOF de los nuevos miembros del grupo Ab (A. dijkshoorniae y A. seifertii) así como ha sido optimizado para el resto de especies del grupo. Rasgos como la formación de biofilm o la virulencia en el modelo animal de Caenhorabditis elegans muestran que A. baumannii, junto con A. nosocomialis, presentan menor potencial patogénico que las otras especies del grupo Ab, y que A. dijkshoorniae es especialmente virulenta. Estos datos sugieren diferentes niveles de adaptación al ámbito hospitalario, y remarca la necesidad de identificar y estudiar las especies del grupo Ab individualmente. Además, a nivel de susceptibilidad antimicrobiana, A. baumannii sigue siendo la especie que presenta mayores tasas de resistencia. Finalmente, hemos hallado nuevas proteínas implicadas en el transporte de membrana que, de manera preliminar, parecen participar en la resistencia a antibióticos y virulencia de A. baumannii, y cuya caracterización podría aportar nuevas dianas para el desarrollo de fármacos antimicrobianos para tratar las infecciones causadas por A. baumannii multirresistente.
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- 2019
106. Comorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer
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Minicozzi, Pamela, Van Eycken, Liesbet, Molinie, Florence, Innos, Kaire, Guevara, Marcela, Marcos-Gragera, Rafael, Castro, Clara, Rapiti, Elisabetta, Katalinic, Alexander, Torrella, Ana, Žagar, Tina, Bielska-Lasota, Magdalena, Giorgi Rossi, Paolo, Larrañaga, Nerea, Bastos, Joana, Sánchez, Maria José, Sant, Milena, and European HR Working Group on breast cancer
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Adult ,population study ,Adolescent ,Mammaplasty ,Age Factors ,Breast Neoplasms ,Comorbidity ,Middle Aged ,comorbidities ,outcomes ,Mastectomy, Segmental ,Combined Modality Therapy ,Time-to-Treatment ,Europe ,Young Adult ,Treatment Outcome ,standard treatment ,Humans ,Female ,Radiotherapy, Adjuvant ,early breast cancer ,Aged - Abstract
Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7581 stage I/IIA cases diagnosed in 9 European countries in 2009-2013, and 4 STs: surgery; breast-conserving surgery plus radiotherapy (BCS + RT); reconstruction after mastectomy; and prompt treatment (≤6 weeks after diagnosis). Covariate-adjusted models estimated odds of receiving STs and risks of death/relapse, according to comorbidities. Pearson's R assessed correlations between odds and risks. The z-test assessed the significance of time-trends. Most women received surgery: 72% BCS; 24% mastectomy. Mastectomied patients were older with more comorbidities than BCS patients (p
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- 2018
107. Erratum to: Worldwide Burden of Gastric Cancer Attributable to Tobacco Smoking in 2012 and Predictions for 2020
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Peleteiro, Bárbara, Castro, Clara, Morais, Samantha, Ferro, Ana, and Lunet, Nuno
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- 2015
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108. Use of nanotechnology in the treatment of head and neck cancer
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Cagigas Castro, Clara, Iturrioz Rodríguez, Nerea, Villegas Sordo, Juan Carlos, and Universidad de Cantabria
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Cáncer cabeza cuello ,Delivery systems ,Nanopartículas ,Sistemas de transporte ,Nanoparticles ,Head and neck cancer - Abstract
Para los pacientes con HNSCC que no son curados por cirugía y/o radioterapia, hay pocas opciones de tratamiento efectivas. La radiorresistencia se ha señalado como la principal causa de fracaso del tratamiento locorregional, y la identificación de los mecanismos moleculares que están detrás de ella podría contribuir a una mejora en la selección del tratamiento y pronóstico. La primera terapia dirigida con éxito (anticuerpos específicos EGFR) ha demostrado que la mejora de la comprensión de los mecanismos moleculares del HNSCC permitirá desarrollar nuevos protocolos de tratamiento. Actualmente, la investigación en el campo del cáncer de cabeza y cuello se está enfocando en el desarrollo de nuevos sistemas de transporte basados en nanotecnología, con el objetivo de hacer frente a los inconvenientes de las actuales técnicas y de mejorar las estrategias de diagnóstico y tratamiento. El propósito de la comunidad científica es el de desarrollar nuevos y más efectivos sistemas para la distribución de los fármacos basados en nanopartículas, optimizando las rutas de tratamiento tanto orales, como bucales e intravenosas y reduciendo los efectos nocivos sobre los tejidos sanos. For patients with HNSCC that are not cured by surgery and/or chemotherapy, there are few effective choices of treatment. Radioresistance has been identified as the main cause of failure of the locoregional treatment, and the identification of the molecular mechanisms that are behind it could contribute to a better selection of treatment and prognosis. The first target therapy with reported success (EGFR specific monoclonal antibodies) has proved that the improvement in the understanding of HNSCC's molecular mechanisms will lead to the development of new treatment protocols. Currently, research in the field of head and neck cancer focuses on the design of new devices based on nanotechnology in order to face the disadvantages of current techniques and to improve diagnosis and treatment strategies. The aim of the scientific community is to develop newer and more effective nanoparticle-based delivery systems, optimizing oral, buccal and intravenous routes of treatment and decreasing toxic effects in healthy tissues. Grado en Medicina
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- 2018
109. La mujer científica y sus grandes descubrimientos
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Carmona Castro, Clara Marina, Vega Holm, Margarita, and Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica
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Ciencia ,Mujer ,Educación ,Igualdad - Abstract
El presente trabajo se ha concebido teniendo como motivación inicial el papel de la mujer en el devenir científico. Resulta impactante como han pasado siglos de historia y la mujer ha estado encasillada a su papel exclusivo de madre y cuidadora de la prole. Los hombres, los hijos, los ascendientes y ellas mismas dignificaban ese papel, lo llenaban de contenido, lo magnificaban y, por tanto, no veían necesario plantearse que la mujer pudiera sentir la necesidad de ser otra cosa sino madre. Los escasos derechos que se le otorgaban estaban dirigidos a potenciar ese rol, para que la maternidad pudiera llevarse a cabo de manera plena. No existía la necesidad de educarla en otra cosa que no fuera el cuidado del hogar, ya que ese entorno es donde se va a desarrollar durante siglos. El ingreso de la mujer en la educación llegó tardío y su evolución fue demasiado lenta, por lo que se tardó muchos años en que la educación a hombres y mujeres fuese igual. Si se habla de la educación universitaria, esta dilató aún más en la llegada a la mujer debido a los continuos impedimentos que a ella se le ponía. Una vez que la educación comenzó a ser semejante y la mujer empezó a indagar con más fuerza en el mundo de la ciencia, volvieron los impedimentos y esto se ve reflejado en la proporción de Premio Nobel otorgados a ellas. Pero, aunque no hayan sido laureadas todas ellas, se han querido destacar diez figuras, empezando por Hipatia de Alejandría, que han contribuido al avance de la ciencia a pesar de las dificultades que han tenido que sobrellevar. Todo esto se ha pretendido recoger, de forma más escueta, en una propuesta de intervención didáctica la cual persigue hacer llegar a los más pequeños la idea de igualdad entre hombres y mujeres y la gran labor que han realizado y realizan mujeres en el ámbito científico. Universidad de Sevilla. Grado en Educación Primaria
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- 2018
110. Fortalecer las habilidades de escritura y oralidad a través de textos descriptivos
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Guzmán Castro, Clara Yanira and Jiménez, Martha Liliana
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Tradición oral ,Oralidad ,FOS: Educational sciences ,Pedagogía ,Unidad didáctica ,Descripción ,Escritura - Enseñanza ,Escritura - Abstract
76 páginas Science and technology have been making progress considerably making incidence in students and teachers' social interaction. That's why, education requires more and new educational and pedagogical practices' strategies, by which students can be guided to transform their knowledge into new ones. Hence, communicative skills play a relevant role in each individual. These skills allow them to explore the world by reading, writing, listening, and speaking, and getting the chance of being more competent from being, knowing and doing perspective in the classroom. Based on the previous constructs, this research project focused on setting and creating a didactic unit in order to strength the orality and reading in students of 3rdgrade at IED Pablo Herrera, Cajica, from descriptive texts. The development of this didactic unit contributed to enhance the students' reading and speaking skills through diverse and new alternatives and strategies adopted in from our own pedagogical practices, allowing pupils to be the main characters that build their own learning. Cada día la ciencia y la tecnología avanzan a pasos gigantescos, haciendo eco en cada uno de los estudiantes y docentes, para comprender la diversidad del entorno social. Por tanto, la educación cada día requiere de más innovación, nuevas estrategias y prácticas pedagógicas, que orienten a los estudiantes a transformar sus saberes por medio de la adquisición de nuevos conocimientos. Es por eso que las habilidades comunicativas juegan un papel fundamental y primordial en la vida de cada ser humano, ellas le permiten conocer el mundo desde la lectura, escritura, escucha y el habla, llevándolos a ser competentes desde el ser, saber y hacer, permitiendo la creación de nuevas ideas para la transformación del conocimiento. Es así que se vio la necesidad de plantear una unidad didáctica que permitiera fortalecer la oralidad y la escritura, en los estudiantes del grado tercero, de la lnstitución Educativa Departamental Rural Pablo Herrera del municipio de Cajicá, a partir de los textos descriptivos. El desarrollo de esta unidad didáctica contribuyó a mejorar las habilidades de escritura y oralidad, a través de nuevas alternativas y estrategias, dadas desde las prácticas pedagógicas de aula, donde el estudiante era el protagonista y quien debía construir su aprendizaje. Maestría Magíster en Educación (Modalidad de Profundización)
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- 2018
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111. L'abordatge de la Violència de Gènere en revistes científiques : estudi de cas de la producció científica a Brasil i Espanya
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Hidalgo Castro, Clara, Universitat Autònoma de Barcelona. Facultat de Psicologia, and Pujol Tarrés, Joan
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Psicothema ,Psicologia ,Brasil ,Espanya ,Violència de gènere ,Revistes científiques ,VG ,Psicologia & Sociedade - Abstract
La recerca sorgeix de la intenció de millorar la comprensió sobre la Violència de Gènere (VG). En concret, sobre com aborda la recerca en psicologia la problemàtica a Espanya i al Brasil, ja que sembla que a Europa es produeix una psicologia més individualista, i a l'Amèrica llatina, més comunitària. L'objectiu plantejat és explorar les diferències entre la producció científica de Brasil i Espanya en relació a la violència de gènere. Per assolir-lo, porto a terme una comparació entre la revista científica espanyola del camp de la Psicologia Psicothema, i la revista Psicologia & Sociedade (P&S), de l'Associació Brasilera de Psicologia Social, a través d'una anàlisi temàtica del contingut dels articles sobre VG de cada revista. S'han extret tres temes de l'anàlisi temàtica. El primer tracta de les comprensions de la VG: sembla que a Psicothema, la VG s'entén sobretot com un problema individual, mentre que a P&S, es conceptualitza com un problema estructural, una construcció social. El segon tracta de les aproximacions a la VG: Psicothema investiga la VG a través de metodologies quantitatives, i P&S ho fa a través de metodologies qualitatives. I tercer, els articles analitzats mostren tres nivells als quals concebre una persona que ha patit VG: com una víctima passiva, com una persona resilient o com un subjecte amb agència. Finalment, analitzo les implicacions socials i acadèmiques de cada resultat, i les relaciono amb problemàtiques d'actualitat, per concloure que sembla que Brasil i Espanya tenen dues línies teòriques diferents en recerca. This research project stems from the intention of improving the comprehension on Gender Violence (VG). In particular, it addresses how psychological research tackle the problem in Spain and Brazil, since it seems that Spain produces more individualist psychology, and in Latin America they put the focus on the community. The aim of this paper is to explore the differences between the Brazilian scientific production and the Spanish one, regarding Gender Violence. In order to achieve it, I make a comparison between the Spanish scientific journal in Psychology Psicothema and the journal Psicologia & Sociedade (P&S), from the Brazilian Association of Social Psychology, through an thematic content analysis, of the papers about VG of each journal. Three topics were extracted from the analysis. The first one is about comprehensions on VG: it seems that in Psicothema, VG is mostly understood as an individual problem, while in P&S, it is seized as a social structural construction. The second one is about the different approaches to VG: Psicothema researches VG through quantitative methods, and P&S does it through qualitative methods. Thirdly, papers analyzed showed three levels of conceiving a person who has suffered VG: as a passive victim, as a resilient person or as a subject with agency. To sum up, I analyze social and academical meanings of each result, and I connect it with current issues, concluding that it seems that Brazil and Spain have two different theoretical lines in research.
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- 2018
112. Microglial response differences between amyloidogenic transgenic models and Alzheimer’s disease patients
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Sanchez-Mejias, Elisabeth, Navarro, Victoria, Nuñez-Diaz, Cristina, Jiménez, Sebastián, Sanchez-Varo, Raquel, Muñoz-Castro, Clara, Vizuete, Marisa, Davila, Jose Carlos, Vitorica, Javier, and Gutierrez-Perez, Antonia
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Microglia ,Alzheimer's disease ,Neurociencias - Congresos - Abstract
Aims: The continuing failure to develop an effective treatment for Alzheimer’s disease (AD) reveals the complexity for AD pathology. Increasing evidence indicates that neuroinflammation involving particularly microglial cells contributes to disease pathogenesis. Here we analyze the differences in the microglial response between APP/PS1 model and human brains. Methods: RT-PCR, western blots, and immunostaining were performed in the hippocampus of human post mortem samples (from Braak II to Braak V-VI) and APP751SL/PS1M146L mice. In vitro studies to check the effect of S1 fractions on microglial cells were assayed. Results: In APP based models the high Abeta accumulation triggers a prominent microglial response. On the contrary, the microglial response detected in human samples is, at least, partial or really mild. This patent difference could simple reflect the lower and probably slower Abeta production observed in human hippocampal samples, in comparison with models or could reflect the consequence of a chronic long-standing microglial activation. However, beside this differential response, we also observed a prominent microglial degenerative process in Braak V-VI samples that, indeed, could compromise their normal role of surveying the brain environment and respond to the damage. This microglial degeneration, particularly relevant at the dentate gyrus of the hippocampal formation, might be mediated by the accumulation of toxic soluble phospho-tau species. Conclusions: These differences need to be considered when delineating animal models that better integrate the complexity of AD pathology and, therefore, guarantee clinical translation. Correcting dysregulated brain inflammatory responses might be a promising avenue to restore cognitive function. Supported by grants FIS PI15/00796 and FIS PI15/00957 co-financed by FEDER funds from European Union, and by Junta de Andalucia Proyecto de Excelencia CTS385 2035. Financiado por FIS PI15/00796 y FIS PI15/0095, cofinanciado por los fondos FEDER de la Unión Europea, y por Junta de Andalucia Proyecto de Excelencia CTS385 2035. Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech.
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- 2018
113. Mechanical and Chemical Factors Required for Maintaining Cardiac Rhythm in Drosophila melanogaster Larva
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Castro, Clara de, primary, Titlow, Josh, additional, Majeed, Zana R., additional, Malloy, Cole, additional, King, Kayla E., additional, and Cooper, Robin L., additional
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- 2019
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114. Chimie et physique chez Sade : Le cas de la Durand et de l’âme ignée
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Castro, Clara Carnicero De, primary
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- 2019
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115. Clinical and Pathologic Profiles of Esophageal Cancer in Mozambique: A Study of Consecutive Patients Admitted to Maputo Central Hospital
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Come, Jotamo, primary, Castro, Clara, additional, Morais, Atílio, additional, Cossa, Matchecane, additional, Modcoicar, Prassad, additional, Tulsidâs, Satish, additional, Cunha, Lina, additional, Lobo, Vitória, additional, Morais, Alberto Gudo, additional, Cotton, Sofia, additional, Lunet, Nuno, additional, Carrilho, Carla, additional, and Santos, Lúcio Lara, additional
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- 2018
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116. Le principe de délicatesse et l'économie libidineuse chez Sade
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de Castro, Clara Carnicero and Fundação de Amparo à Pesquisa do Estado de São Paulo
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Sade ,économie libidineuse ,lcsh:Philosophy (General) ,lcsh:B ,principe de délicatesse ,Filosofia Moderna ,Românce filosófico ,lcsh:Philosophy. Psychology. Religion ,lcsh:B1-5802 ,délicatesse scélérate ,prodigalité luxurieuse - Abstract
Dans une lettre à son épouse, Sade fait l'éloge de la bizarrerie et l’élève au rang de catégorie esthétique sous le nom de « principe de délicatesse ». Cela peut sembler paradoxal, comme l'a bien remarqué Michel Delon, que celui qui énonce le devoir de délicatesse est celui-là même dont le nom est devenu synonyme de brutalité. Le terme est en effet ambigu et possède dans l'oeuvre du marquis plusieurs sens: de l'échange de soins entre Juliette et sa maîtresse préférée La Durand, en passant par une simple manie sexuelle, jusqu'à la fantaisie « la plus bizarre et la plus singulière de toutes », celle qui dépend d'une richesse fastueuse et qui ne s'achève que sur un tas de corps baignés de sang. Il s'agit d'abord d'examiner les différents sens du terme chez Sade ; puis d'analyser les interprétations que Roland Barthes, Annie Le Brun et Michel Delon donnent de la délicatesse scélérate ; enfin de mettre en évidence sa spécificité par rapport à la prodigalité luxurieuse.
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- 2015
117. Amyloid‐β impairs the phagocytosis of dystrophic synapses by astrocytes in Alzheimer's disease.
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Sanchez‐Mico, Maria V., Jimenez, Sebastian, Gomez‐Arboledas, Angela, Muñoz‐Castro, Clara, Romero‐Molina, Carmen, Navarro, Victoria, Sanchez‐Mejias, Elisabeth, Nuñez‐Diaz, Cristina, Sanchez‐Varo, Raquel, Galea, Elena, Davila, José C., Vizuete, Marisa, Gutierrez, Antonia, and Vitorica, Javier
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- 2021
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118. Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
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Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Instituto de Biomedicina de Sevilla (IBIS), Romero Molina, Carmen, Navarro Garrido, Victoria, Sánchez Varo, Raquel María, Jiménez Muñoz, Sebastián, Fernández Valenzuela, Juan José, Sánchez Mico, María, Muñoz Castro, Clara, Gutiérrez Pérez, Antonia, Vitorica Ferrández, Francisco Javier, Vizuete Chacón, María Luisa, Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Instituto de Biomedicina de Sevilla (IBIS), Romero Molina, Carmen, Navarro Garrido, Victoria, Sánchez Varo, Raquel María, Jiménez Muñoz, Sebastián, Fernández Valenzuela, Juan José, Sánchez Mico, María, Muñoz Castro, Clara, Gutiérrez Pérez, Antonia, Vitorica Ferrández, Francisco Javier, and Vizuete Chacón, María Luisa
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Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology but, comparatively, little is known about inflammatory processes associated to tau pathology. In the hippocampus of AD patients, where tau pathology is more prominent than amyloid-beta pathology, a microglial degenerative process has been reported. In this work, we have directly compared the microglial response in two different transgenic tau mouse models: ThyTau22 and P301S. Surprisingly, these two models showed important differences in the microglial profile and tau pathology. Where ThyTau22 hippocampus manifested mild microglial activation, P301S mice exhibited a strong microglial response in parallel with high phospho-tau accumulation. This differential phospho-tau expression could account for the different microglial response in these two tau strains. However, soluble (S1) fractions from ThyTau22 hippocampus presented relatively high content of soluble phospho-tau (AT8-positive) and were highly toxic for microglial cells in vitro, whereas the correspondent S1 fractions from P301S mice displayed low soluble phosphotau levels and were not toxic for microglial cells. Therefore, not only the expression levels but the aggregation of phospho-tau should differ between both models. In fact, most of tau forms in the P301S mice were aggregated and, in consequence, forming insoluble tau species.We conclude that different factors as tau mutations, accumulation, phosphorylation, and/or aggregation could account for the distinct microglial responses observed in these two tau models. For this reason, deciphering the molecular nature of toxic tau species for microglial cells might be a promising therapeutic approach in order to restore the deficient immunological protection observed in AD hippocampus.
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- 2018
119. Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
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Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Universidad de Sevilla. CTS257: Envejecimiento y Neurodegeneración, Instituto de Salud Carlos III, Junta de Andalucía, Navarro Garrido, Victoria, Sánchez Mejías, Elisabeth, Jiménez Muñoz, Sebastián, Muñoz Castro, Clara, Sánchez Varo, Raquel María, Dávila, José Carlos, Vizuete Chacón, María Luisa, Gutiérrez, Antonia, Vitorica Ferrández, Francisco Javier, Universidad de Sevilla. Departamento de Bioquímica y Biología Molecular, Universidad de Sevilla. CTS257: Envejecimiento y Neurodegeneración, Instituto de Salud Carlos III, Junta de Andalucía, Navarro Garrido, Victoria, Sánchez Mejías, Elisabeth, Jiménez Muñoz, Sebastián, Muñoz Castro, Clara, Sánchez Varo, Raquel María, Dávila, José Carlos, Vizuete Chacón, María Luisa, Gutiérrez, Antonia, and Vitorica Ferrández, Francisco Javier
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- 2018
120. La mujer científica y sus grandes descubrimientos
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Vega Holm, Margarita, Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica, Carmona Castro, Clara Marina, Vega Holm, Margarita, Universidad de Sevilla. Departamento de Química Orgánica y Farmacéutica, and Carmona Castro, Clara Marina
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El presente trabajo se ha concebido teniendo como motivación inicial el papel de la mujer en el devenir científico. Resulta impactante como han pasado siglos de historia y la mujer ha estado encasillada a su papel exclusivo de madre y cuidadora de la prole. Los hombres, los hijos, los ascendientes y ellas mismas dignificaban ese papel, lo llenaban de contenido, lo magnificaban y, por tanto, no veían necesario plantearse que la mujer pudiera sentir la necesidad de ser otra cosa sino madre. Los escasos derechos que se le otorgaban estaban dirigidos a potenciar ese rol, para que la maternidad pudiera llevarse a cabo de manera plena. No existía la necesidad de educarla en otra cosa que no fuera el cuidado del hogar, ya que ese entorno es donde se va a desarrollar durante siglos. El ingreso de la mujer en la educación llegó tardío y su evolución fue demasiado lenta, por lo que se tardó muchos años en que la educación a hombres y mujeres fuese igual. Si se habla de la educación universitaria, esta dilató aún más en la llegada a la mujer debido a los continuos impedimentos que a ella se le ponía. Una vez que la educación comenzó a ser semejante y la mujer empezó a indagar con más fuerza en el mundo de la ciencia, volvieron los impedimentos y esto se ve reflejado en la proporción de Premio Nobel otorgados a ellas. Pero, aunque no hayan sido laureadas todas ellas, se han querido destacar diez figuras, empezando por Hipatia de Alejandría, que han contribuido al avance de la ciencia a pesar de las dificultades que han tenido que sobrellevar. Todo esto se ha pretendido recoger, de forma más escueta, en una propuesta de intervención didáctica la cual persigue hacer llegar a los más pequeños la idea de igualdad entre hombres y mujeres y la gran labor que han realizado y realizan mujeres en el ámbito científico.
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- 2018
121. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017
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Roth, G, Abate, D, Abate, K, Abay, S, Abbafati, C, Abbasi, N, Abbastabar, H, Abd-Allah, F, Abdela, J, Abdelalim, A, Abdollahpour, I, Abdulkader, R, Abebe, H, Abebe, M, Abebe, Z, Abejie, A, Abera, S, Abil, O, Abraha, H, Abrham, A, Abu-Raddad, L, Accrombessi, M, Acharya, D, Adamu, A, Adebayo, O, Adedoyin, R, Adekanmbi, V, Adetokunboh, O, Adhena, B, Adib, M, Admasie, A, Afshin, A, Agarwal, G, Agesa, K, Agrawal, A, Agrawal, S, Ahmadi, A, Ahmadi, M, Ahmed, M, Ahmed, S, Aichour, A, Aichour, I, Aichour, M, Akbari, M, Akinyemi, R, Akseer, N, Al-Aly, Z, Al-Eyadhy, A, Al-Raddadi, R, Alahdab, F, Alam, K, Alam, T, Alebel, A, Alene, K, Alijanzadeh, M, Alizadeh-Navaei, R, Aljunid, S, Alkerwi, A, Alla, F, Allebeck, P, Alonso, J, Altirkawi, K, Alvis-Guzman, N, Amare, A, Aminde, L, Amini, E, Ammar, W, Amoako, Y, Anber, N, Andrei, C, Androudi, S, Animut, M, Anjomshoa, M, Ansari, H, Ansha, M, Antonio, C, Anwari, P, Aremu, O, Arnlov, J, Arora, A, Arora, M, Artaman, A, Aryal, K, Asayesh, H, Asfaw, E, Ataro, Z, Atique, S, Atre, S, Ausloos, M, Avokpaho, E, Awasthi, A, Ayala Quintanilla, B, Ayele, Y, Ayer, R, Azzopardi, P, Babazadeh, A, Bacha, U, Badali, H, Badawi, A, Bali, A, Ballesteros, K, Banach, M, Banerjee, K, Bannick, M, Banoub, J, Barboza, M, Barker-Collo, S, Barnighausen, T, Barquera, S, Barrero, L, Bassat, Q, Basu, S, Baune, B, Baynes, H, Bazargan-Hejazi, S, Bedi, N, Beghi, E, Behzadifar, M, Bejot, Y, Bekele, B, Belachew, A, Belay, E, Belay, Y, Bell, M, Bello, A, Bennett, D, Bensenor, I, Berman, A, Bernabe, E, Bernstein, R, Bertolacci, G, Beuran, M, Beyranvand, T, Bhalla, A, Bhattarai, S, Bhaumik, S, Bhutta, Z, Biadgo, B, Biehl, M, Bijani, A, Bikbov, B, Bilano, V, Bililign, N, Bin Sayeed, M, Bisanzio, D, Biswas, T, Blacker, B, Basara, B, Borschmann, R, Bosetti, C, Bozorgmehr, K, Brady, O, Brant, L, Brayne, C, Brazinova, A, Breitborde, N, Brenner, H, Briant, P, Britton, G, Brugha, T, Busse, R, Butt, Z, Callender, C, Campos-Nonato, I, Campuzano Rincon, J, Cano, J, Car, M, Cardenas, R, Carreras, G, Carrero, J, Carter, A, Carvalho, F, Castaneda-Orjuela, C, Castillo Rivas, J, Castle, C, Castro, C, Castro, F, Catala-Lopez, F, Cerin, E, Chaiah, Y, Chang, J, Charlson, F, Chaturvedi, P, Chiang, P, Chimed-Ochir, O, Chisumpa, V, Chitheer, A, Chowdhury, R, Christensen, H, Christopher, D, Chung, S, Cicuttini, F, Ciobanu, L, Cirillo, M, Cohen, A, Cooper, L, Cortesi, P, Cortinovis, M, Cousin, E, Cowie, B, Criqui, M, Cromwell, E, Crowe, C, Crump, J, Cunningham, M, Daba, A, Dadi, A, Dandona, L, Dandona, R, Dang, A, Dargan, P, Daryani, A, Das, S, Gupta, R, Neves, J, Dasa, T, Dash, A, Davis, A, Davis Weaver, N, Davitoiu, D, Davletov, K, De La Hoz, F, De Neve, J, Degefa, M, Degenhardt, L, Degfie, T, Deiparine, S, Demoz, G, Demtsu, B, Denova-Gutierrez, E, Deribe, K, Dervenis, N, Des Jarlais, D, Dessie, G, Dey, S, Dharmaratne, S, Dicker, D, Dinberu, M, Ding, E, Dirac, M, Djalalinia, S, Dokova, K, Doku, D, Donnelly, C, Dorsey, E, Doshi, P, Douwes-Schultz, D, Doyle, K, Driscoll, T, Dubey, M, Dubljanin, E, Duken, E, Duncan, B, Duraes, A, Ebrahimi, H, Ebrahimpour, S, Edessa, D, Edvardsson, D, Eggen, A, El Bcheraoui, C, El Sayed Zaki, M, El-Khatib, Z, Elkout, H, Ellingsen, C, Endres, M, Endries, A, Er, B, Erskine, H, Eshrati, B, Eskandarieh, S, Esmaeili, R, Esteghamati, A, Fakhar, M, Fakhim, H, Faramarzi, M, Fareed, M, Farhadi, F, Farinha, C, Faro, A, Farvid, M, Farzadfar, F, Farzaei, M, Feigin, V, Feigl, A, Fentahun, N, Fereshtehnejad, S, Fernandes, E, Fernandes, J, Ferrari, A, Feyissa, G, Filip, I, Finegold, S, Fischer, F, Fitzmaurice, C, Foigt, N, Foreman, K, Fornari, C, Frank, T, Fukumoto, T, Fuller, J, Fullman, N, Furst, T, Furtado, J, Futran, N, Gallus, S, Garcia-Basteiro, A, Garcia-Gordillo, M, Gardner, W, Gebre, A, Gebrehiwot, T, Gebremedhin, A, Gebremichael, B, Gebremichael, T, Gelano, T, Geleijnse, J, Genova-Maleras, R, Geramo, Y, Gething, P, Gezae, K, Ghadami, M, Ghadimi, R, Ghasemi Falavarjani, K, Ghasemi-Kasman, M, Ghimire, M, Gibney, K, Gill, P, Gill, T, Gillum, R, Ginawi, I, Giroud, M, Giussani, G, Goenka, S, Goldberg, E, Goli, S, Gomez-Dantes, H, Gona, P, Gopalani, S, Gorman, T, Goto, A, Goulart, A, Gnedovskaya, E, Grada, A, Grosso, G, Gugnani, H, Guimaraes, A, Guo, Y, Gupta, P, Gupta, T, Gutierrez, R, Gyawali, B, Haagsma, J, Hafezi-Nejad, N, Hagos, T, Hailegiyorgis, T, Hailu, G, Haj-Mirzaian, A, Hamadeh, R, Hamidi, S, Handal, A, Hankey, G, Harb, H, Harikrishnan, S, Haro, J, Hasan, M, Hassankhani, H, Hassen, H, Havmoeller, R, Hay, R, Hay, S, He, Y, Hedayatizadeh-Omran, A, Hegazy, M, Heibati, B, Heidari, M, Hendrie, D, Henok, A, Henry, N, Herteliu, C, Heydarpour, F, Heydarpour, P, Heydarpour, S, Hibstu, D, Hoek, H, Hole, M, Homaie Rad, E, Hoogar, P, Hosgood, H, Hosseini, S, Hosseinzadeh, M, Hostiuc, M, Hostiuc, S, Hotez, P, Hoy, D, Hsiao, T, Hu, G, Huang, J, Husseini, A, Hussen, M, Hutfless, S, Idrisov, B, Ilesanmi, O, Iqbal, U, Irvani, S, Irvine, C, Islam, N, Islam, S, Islami, F, Jacobsen, K, Jahangiry, L, Jahanmehr, N, Jain, S, Jakovljevic, M, Jalu, M, James, S, Javanbakht, M, Jayatilleke, A, Jeemon, P, Jenkins, K, Jha, R, Jha, V, Johnson, C, Johnson, S, Jonas, J, Joshi, A, Jozwiak, J, Jungari, S, Jurisson, M, Kabir, Z, Kadel, R, Kahsay, A, Kalani, R, Karami, M, Karami Matin, B, Karch, A, Karema, C, Karimi-Sari, H, Kasaeian, A, Kassa, D, Kassa, G, Kassa, T, Kassebaum, N, Katikireddi, S, Kaul, A, Kazemi, Z, Kazemi Karyani, A, Kazi, D, Kefale, A, Keiyoro, P, Kemp, G, Kengne, A, Keren, A, Kesavachandran, C, Khader, Y, Khafaei, B, Khafaie, M, Khajavi, A, Khalid, N, Khalil, I, Khan, E, Khan, M, Khang, Y, Khater, M, Khoja, A, Khosravi, A, Khosravi, M, Khubchandani, J, Kiadaliri, A, Kibret, G, Kidanemariam, Z, Kiirithio, D, Kim, D, Kim, Y, Kimokoti, R, Kinfu, Y, Kisa, A, Kissimova-Skarbek, K, Kivimaki, M, Knudsen, A, Kocarnik, J, Kochhar, S, Kokubo, Y, Kolola, T, Kopec, J, Koul, P, Koyanagi, A, Kravchenko, M, Krishan, K, Kuate Defo, B, Kucuk Bicer, B, Kumar, G, Kumar, M, Kumar, P, Kutz, M, 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Ashworth, Djalalinia, Shirin, Dokova, Klara, Doku, David Teye, Donnelly, Christl A., Dorsey, E. Ray, Doshi, Pratik P., Douwes-Schultz, Dirk, Doyle, Kerrie E., Driscoll, Tim R., Dubey, Manisha, Dubljanin, Eleonora, Duken, Eyasu Ejeta, Duncan, Bruce B., Duraes, Andre R., Ebrahimi, Hedyeh, Ebrahimpour, Soheil, Edessa, Dumessa, Edvardsson, David, Eggen, Anne Elise, El Bcheraoui, Charbel, El Sayed Zaki, Maysaa, El-Khatib, Ziad, Elkout, Hajer, Ellingsen, Christian Lycke, Endres, Matthias, Endries, Aman Yesuf, Er, Benjamin, Erskine, Holly E., Eshrati, Babak, Eskandarieh, Sharareh, Esmaeili, Reza, Esteghamati, Alireza, Fakhar, Mahdi, Fakhim, Hamed, Faramarzi, Mahbobeh, Fareed, Mohammad, Farhadi, Farzaneh, Farinha, Carla Sofia Esá, Faro, Andre, Farvid, Maryam S., Farzadfar, Farshad, Farzaei, Mohammad Hosein, Feigin, Valery L., Feigl, Andrea B., Fentahun, Netsanet, Fereshtehnejad, Seyed-Mohammad, Fernandes, Eduarda, Fernandes, Joao C., Ferrari, Alize J., Feyissa, Garumma Tolu, Filip, Irina, Finegold, Samuel, Fischer, Florian, Fitzmaurice, Christina, Foigt, Nataliya A., Foreman, Kyle J., Fornari, Carla, Frank, Tahvi D., Fukumoto, Takeshi, Fuller, John E., Fullman, Nancy, Furst, Thomas, Furtado, Joao M., Futran, Neal D., Gallus, Silvano, Garcia-Basteiro, Alberto L., Garcia-Gordillo, Miguel A., Gardner, William M., Gebre, Abadi Kahsu, Gebrehiwot, Tsegaye Tewelde, Gebremedhin, Amanuel Tesfay, Gebremichael, Bereket, Gebremichael, Teklu Gebrehiwo, Gelano, Tilayie Feto, Geleijnse, Johanna M., Genova-Maleras, Ricard, Geramo, Yilma Chisha Dea, Gething, Peter W., Gezae, Kebede Embaye, Ghadami, Mohammad Rasoul, Ghadimi, Reza, Ghasemi Falavarjani, Khalil, Ghasemi-Kasman, Maryam, Ghimire, Mamata, Gibney, Katherine B., Gill, Paramjit Singh, Gill, Tiffany K., Gillum, Richard F., Ginawi, Ibrahim Abdelmageed, Giroud, Maurice, Giussani, Giorgia, Goenka, Shifalika, Goldberg, Ellen M., Goli, Srinivas, Gomez-Dantes, Hector, Gona, Philimon N., Gopalani, Sameer Vali, Gorman, Taren M., Goto, Atsushi, Goulart, Alessandra C., Gnedovskaya, Elena V., Grada, Ayman, Grosso, Giuseppe, Gugnani, Harish Chander, Guimaraes, Andre Luiz Sena, Guo, Yuming, Gupta, Prakash C., Gupta, Rahul, Gupta, Rajeev, Gupta, Tanush, Gutierrez, Reyna Alma, Gyawali, Bishal, Haagsma, Juanita A., Hafezi-Nejad, Nima, Hagos, Tekleberhan B., Hailegiyorgis, Tewodros Tesfa, Hailu, Gessessew Bugssa, Haj-Mirzaian, Arvin, Haj-Mirzaian, Arya, Hamadeh, Randah R., Hamidi, Samer, Handal, Alexis J., Hankey, Graeme J., Harb, Hilda L., Harikrishnan, Sivadasanpillai, Haro, Josep Maria, Hasan, Mehedi, Hassankhani, Hadi, Hassen, Hamid Yimam, Havmoeller, Rasmus, Hay, Roderick J., Hay, Simon I., He, Yihua, Hedayatizadeh-Omran, Akbar, Hegazy, Mohamed I., Heibati, Behzad, Heidari, Mohsen, Hendrie, Delia, Henok, Andualem, Henry, Nathaniel J., Herteliu, Claudiu, Heydarpour, Fatemeh, Heydarpour, Pouria, Heydarpour, Sousan, Hibstu, Desalegn Tsegaw, Hoek, Hans W., Hole, Michael K., Homaie Rad, Enayatollah, Hoogar, Praveen, Hosgood, H. Dean, Hosseini, Seyed Mostafa, Hosseinzadeh, Mehdi, Hostiuc, Mihaela, Hostiuc, Sorin, Hotez, Peter J., Hoy, Damian G., Hsiao, Thomas, Hu, Guoqing, Huang, John J., Husseini, Abdullatif, Hussen, Mohammedaman Mama, Hutfless, Susan, Idrisov, Bulat, Ilesanmi, Olayinka Stephen, Iqbal, Usman, Irvani, Seyed Sina Naghibi, Irvine, Caleb Mackay Salpeter, Islam, Nazrul, Islam, Sheikh Mohammed Shariful, Islami, Farhad, Jacobsen, Kathryn H., Jahangiry, Leila, Jahanmehr, Nader, Jain, Sudhir Kumar, Jakovljevic, Mihajlo, Jalu, Moti Tolera, James, Spencer L., Javanbakht, Mehdi, Jayatilleke, Achala Upendra, Jeemon, Panniyammakal, Jenkins, Kathy J., Jha, Ravi Prakash, Jha, Vivekanand, Johnson, Catherine O., Johnson, Sarah C., Jonas, Jost B., Joshi, Ankur, Jozwiak, Jacek Jerzy, Jungari, Suresh Banayya, Jurisson, Mikk, Kabir, Zubair, Kadel, Rajendra, Kahsay, Amaha, Kalani, Rizwan, Karami, Manoochehr, Karami Matin, Behzad, Karch, Andre, Karema, Corine, Karimi-Sari, Hamidreza, Kasaeian, Amir, Kassa, Dessalegn H., Kassa, Getachew Mullu, Kassa, Tesfaye Dessale, Kassebaum, Nicholas J., Katikireddi, Srinivasa Vittal, Kaul, Anil, Kazemi, Zhila, Kazemi Karyani, Ali, Kazi, Dhruv Satish, Kefale, Adane Teshome, Keiyoro, Peter Njenga, Kemp, Grant Rodgers, Kengne, Andre Pascal, Keren, Andre, Kesavachandran, Chandrasekharan Nair, Khader, Yousef Saleh, Khafaei, Behzad, Khafaie, Morteza Abdullatif, Khajavi, Alireza, Khalid, Nauman, Khalil, Ibrahim A., Khan, Ejaz Ahmad, Khan, Muhammad Shahzeb, Khan, Muhammad Ali, Khang, Young-Ho, Khater, Mona M., Khoja, Abdullah T., Khosravi, Ardeshir, Khosravi, Mohammad Hossein, Khubchandani, Jagdish, Kiadaliri, Aliasghar A., Kibret, Getiye D., Kidanemariam, Zelalem Teklemariam, Kiirithio, Daniel N., Kim, Daniel, Kim, Young-Eun, Kim, Yun Jin, Kimokoti, Ruth W., Kinfu, Yohannes, Kisa, Adnan, Kissimova-Skarbek, Katarzyna, Kivimaki, Mika, Knudsen, Ann Kristin Skrindo, Kocarnik, Jonathan M., Kochhar, Sonali, Kokubo, Yoshihiro, Kolola, Tufa, Kopec, Jacek A., Koul, Parvaiz A., Koyanagi, Ai, Kravchenko, Michael A., Krishan, Kewal, Kuate Defo, Barthelemy, Kucuk Bicer, Burcu, Kumar, G. Anil, Kumar, Manasi, Kumar, Pushpendra, Kutz, Michael J., Kuzin, Igor, Kyu, Hmwe Hmwe, Lad, Deepesh P., Lad, Sheetal D., Lafranconi, Alessandra, Lal, Dharmesh Kumar, Lalloo, Ratilal, Lallukka, Tea, Lam, Jennifer O., Lami, Faris Hasan, Lansingh, Van C., Lansky, Sonia, Larson, Heidi J., Latifi, Arman, Lau, Kathryn Mei-Ming, Lazarus, Jeffrey V., Lebedev, Georgy, Lee, Paul H., Leigh, James, Leili, Mostafa, Leshargie, Cheru Tesema, Li, Shanshan, Li, Yichong, Liang, Juan, Lim, Lee-Ling, Lim, Stephen S., Limenih, Miteku Andualem, Linn, Shai, Liu, Shiwei, Liu, Yang, Lodha, Rakesh, Lonsdale, Chris, Lopez, Alan D., Lorkowski, Stefan, Lotufo, Paulo A., Lozano, Rafael, Lunevicius, Raimundas, Ma, Stefan, Macarayan, Erlyn Rachelle King, Mackay, Mark T., MacLachlan, Jennifer H., Maddison, Emilie R., Madotto, Fabiana, Magdy Abd El Razek, Hassan, Magdy Abd El Razek, Muhammed, Maghavani, Dhaval P., Majdan, Marek, Majdzadeh, Reza, Majeed, Azeem, Malekzadeh, Reza, Malta, Deborah Carvalho, Manda, Ana-Laura, Mandarano-Filho, Luiz Garcia, Manguerra, Helena, Mansournia, Mohammad Ali, Mapoma, Chabila Christopher, Marami, Dadi, Maravilla, Joemer C., Marcenes, Wagner, Marczak, Laurie, Marks, Ashley, Marks, Guy B., Martinez, Gabriel, Martins-Melo, Francisco Rogerlandio, Martopullo, Ira, Marz, Winfried, Marzan, Melvin B., Masci, Joseph R., Massenburg, Benjamin Ballard, Mathur, Manu Raj, Mathur, Prashant, Matzopoulos, Richard, Maulik, Pallab K., Mazidi, Mohsen, McAlinden, Colm, McGrath, John J., McKee, Martin, McMahon, Brian J., Mehata, Suresh, Mehndiratta, Man Mohan, Mehrotra, Ravi, Mehta, Kala M., Mehta, Varshil, Mekonnen, Tefera C., Melese, Addisu, Melku, Mulugeta, Memiah, Peter T. N., Memish, Ziad A., Mendoza, Walter, Mengistu, Desalegn Tadese, Mengistu, Getnet, Mensah, George A., Mereta, Seid Tiku, Meretoja, Atte, Meretoja, Tuomo J., Mestrovic, Tomislav, Mezgebe, Haftay Berhane, Miazgowski, Bartosz, Miazgowski, Tomasz, Millear, Anoushka I., Miller, Ted R., Miller-Petrie, Molly Katherine, Mini, G. K., Mirabi, Parvaneh, Mirarefin, Mojde, Mirica, Andreea, Mirrakhimov, Erkin M., Misganaw, Awoke Temesgen, Mitiku, Habtamu, Moazen, Babak, Mohammad, Karzan Abdulmuhsin, Mohammadi, Moslem, Mohammadifard, Noushin, Mohammed, Mohammed A., Mohammed, Shafiu, Mohan, Viswanathan, Mokdad, Ali H., Molokhia, Mariam, Monasta, Lorenzo, Moradi, Ghobad, Moradi-Lakeh, Maziar, Moradinazar, Mehdi, Moraga, Paula, Morawska, Lidia, Velasquez, Ilais Moreno, Morgado-Da-Costa, Joana, Morrison, Shane Douglas, Moschos, Marilita M., Mouodi, Simin, Mousavi, Seyyed Meysam, Muchie, Kindie Fentahun, Mueller, Ulrich Otto, Mukhopadhyay, Satinath, Muller, Kate, Mumford, John Everett, Musa, Jonah, Musa, Kamarul Imran, Mustafa, Ghulam, Muthupandian, Saravanan, Nachega, Jean B., Nagel, Gabriele, Naheed, Aliya, Nahvijou, Azin, Naik, Gurudatta, Nair, Sanjeev, Najafi, Farid, Naldi, Luigi, Nam, Hae Sung, Nangia, Vinay, Nansseu, Jobert Richie, Nascimento, Bruno Ramos, Natarajan, Gopalakrishnan, Neamati, Nahid, Negoi, Ionut, Negoi, Ruxandra Irina, Neupane, Subas, Newton, Charles R. J., Ngalesoni, Frida N., Ngunjiri, Josephine W., Nguyen, Anh Quynh, Nguyen, Grant, Nguyen, Ha Thu, Nguyen, Huong Thanh, Nguyen, Long Hoang, Nguyen, Minh, Nguyen, Trang Huyen, Nichols, Emma, Ningrum, Dina Nur Anggraini, Nirayo, Yirga Legesse, Nixon, Molly R., Nolutshungu, Nomonde, Nomura, Shuhei, Norheim, Ole F., Noroozi, Mehdi, Norrving, Bo, Noubiap, Jean Jacques, Nouri, Hamid Reza, Shiadeh, Malihe Nourollahpour, Nowroozi, Mohammad Reza, Nyasulu, Peter S., Odell, Christopher M., Ofori-Asenso, Richard, Ogbo, Felix Akpojene, Oh, In-Hwan, Oladimeji, Olanrewaju, Olagunju, Andrew T., Olivares, Pedro R., Olsen, Helen Elizabeth, Olusanya, Bolajoko Olubukunola, Olusanya, Jacob Olusegun, Ong, Kanyin L., Ong, Sok King Sk, Oren, Eyal, Orpana, Heather M., Ortiz, Alberto, Ortiz, Justin R., Otstavnov, Stanislav S., Overland, Simon, Owolabi, Mayowa Ojo, Ozdemir, Raziye, Mahesh, P. A., Pacella, Rosana, Pakhale, Smita, Pakhare, Abhijit P., Pakpour, Amir H., Pana, Adrian, Panda-Jonas, Songhomitra, Pandian, Jeyaraj Durai, Parisi, Andrea, Park, Eun-Kee, Parry, Charles D. H., Parsian, Hadi, Patel, Shanti, Pati, Sanghamitra, Patton, George C., Paturi, Vishnupriya Rao, Paulson, Katherine R., Pereira, Alexandre, Pereira, David M., Perico, Norberto, Pesudovs, Konrad, Petzold, Max, Phillips, Michael R., Piel, Frederic B., Pigott, David M., Pillay, Julian David, Pirsaheb, Meghdad, Pishgar, Farhad, Polinder, Suzanne, Postma, Maarten J., Pourshams, Akram, Poustchi, Hossein, Pujar, Ashwini, Prakash, Swayam, Prasad, Narayan, Purcell, Caroline A., Qorbani, Mostafa, Quintana, Hedley, Quistberg, D. Alex, Rade, Kirankumar Waman, Anwar Rafay, Amir Radfar, Rahim, Alireza Rafiei Fakher, Rahimi, Kazem, Rahimi-Movaghar, Afarin, Rahman, Mahfuzar, Rahman, Mohammad Hifz Ur, Rahman, Muhammad Aziz, Rai, Rajesh Kumar, Rajsic, Sasa, Ram, Usha, Ranabhat, Chhabi Lal, Ranjan, Prabhat, Rao, Puja C., Rawaf, David Laith, Rawaf, Salman, Razo-Garcia, Christian, Reddy, K. Srinath, Reiner, Robert C., Reitsma, Marissa B., Remuzzi, Giuseppe, Renzaho, Andre M. N., Resnikoff, Serge, Rezaei, Satar, Rezaeian, Shahab, Rezai, Mohammad Sadegh, Riahi, Seyed Mohammad, Ribeiro, Antonio Luiz P., Rios-Blancas, Maria Jesus, Roba, Kedir Teji, Roberts, Nicholas L. S., Robinson, Stephen R., Roever, Leonardo, Ronfani, Luca, Roshandel, Gholamreza, Rostami, Ali, Rothenbacher, Dietrich, Roy, Ambuj, Rubagotti, Enrico, Sachdev, Perminder S., Saddik, Basema, Sadeghi, Ehsan, Safari, Hosein, Safdarian, Mahdi, Safi, Sare, Safiri, Saeid, Sagar, Rajesh, Sahebkar, Amirhossein, Sahraian, Mohammad Ali, Salam, Nasir, Salama, Joseph S., Salamati, Payman, De Freitas Saldanha, Raphael, Saleem, Zikria, Salimi, Yahya, Salvi, Sundeep Santosh, Salz, Inbal, Sambala, Evanson Zondani, Samy, Abdallah M., Sanabria, Juan, Dolores Sanchez-Nino, Maria, Santomauro, Damian Francesco, Santos, Itamar S., Santos, Joao Vasco, Santric Milicevic, Milena M., Jose, Bruno Piassi Sao, Sarker, Abdur Razzaque, Sarmiento-Suarez, Rodrigo, Sarrafzadegan, Nizal, Sartorius, Benn, Sarvi, Shahabeddin, Sathian, Brijesh, Satpathy, Maheswar, Sawant, Arundhati R., Sawhney, Monika, Saxena, Sonia, Sayyah, Mehdi, Schaeffner, Elke, Schmidt, Maria Ines, Schneider, Ione J. C., Schottker, Ben, Schutte, Aletta Elisabeth, Schwebel, David C., Schwendicke, Falk, Scott, James G., Sekerija, Mario, Sepanlou, Sadaf G., Servan-Mori, Edson, Seyedmousavi, Seyedmojtaba, Shabaninejad, Hosein, Shackelford, Katya Anne, Shafieesabet, Azadeh, Shahbazi, Mehdi, Shaheen, Amira A., Shaikh, Masood Ali, Shams-Beyranvand, Mehran, Shamsi, Mohammadbagher, Shamsizadeh, Morteza, Sharafi, Kiomars, Sharif, Mehdi, Sharif-Alhoseini, Mahdi, Sharma, Rajesh, She, Jun, Sheikh, Aziz, Shi, Peilin, Shiferaw, Mekonnen Sisay, Shigematsu, Mika, Shiri, Rahman, Shirkoohi, Reza, Shiue, Ivy, Shokraneh, Farhad, Shrime, Mark G., Si, Si, Siabani, Soraya, Siddiqi, Tariq J., Sigfusdottir, Inga Dora, Sigurvinsdottir, Rannveig, Silberberg, Donald H., Santos Silva, Diego Augusto, Silva, Joao Pedro, Da Silva, Natacha Torres, Silveira, Dayane Gabriele Alves, Singh, Jasvinder A., Singh, Narinder Pal, Singh, Prashant Kumar, Singh, Virendra, Sinha, Dhirendra Narain, Sliwa, Karen, Smith, Mari, Sobaih, Badr Hasan, Sobhani, Soheila, Sobngwi, Eugene, Soneji, Samir S., Soofi, Moslem, Sorensen, Reed J. D., Soriano, Joan B., Soyiri, Ireneous N., Sposato, Luciano A., Sreeramareddy, Chandrashekhar T., Srinivasan, Vinay, Stanaway, Jeffrey D., Starodubov, Vladimir I., Stathopoulou, Vasiliki, Stein, Dan J., Steiner, Caitlyn, Stewart, Leo G., Stokes, Mark A., Subart, Michelle L., Sudaryanto, Agus, Sufiyan, Mu'Awiyyah Babale, Sur, Patrick John, Sutradhar, Ipsita, Sykes, Bryan L., Sylaja, P. N., Sylte, Dillon O., Szoeke, Cassandra E. 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Eoin, Westerman, Ronny, Whiteford, Harvey A., Widecka, Justyna, Wilner, Lauren B., Wilson, Shadrach, Winkler, Andrea Sylvia, Wiysonge, Charles Shey, Wolfe, Charles D. A., Wu, Shouling, Wu, Yun-Chun, Wyper, Grant M. A., Xavier, Denis, Xu, Gelin, Yadgir, Simon, Yadollahpour, Ali, Yahyazadeh Jabbari, Seyed Hossein, Yakob, Bereket, Yan, Lijing L., Yano, Yuichiro, Yaseri, Mehdi, Yasin, Yasin Jemal, Yentur, Gokalp Kadri, Yeshaneh, Alex, Yimer, Ebrahim M., Yip, Paul, Yirsaw, Biruck Desalegn, Yisma, Engida, Yonemoto, Naohiro, Yonga, Gerald, Yoon, Seok-Jun, Yotebieng, Marcel, Younis, Mustafa Z., Yousefifard, Mahmoud, Yu, Chuanhua, Zadnik, Vesna, Zaidi, Zoubida, Zaman, Sojib Bin, Zamani, Mohammad, Zare, Zohreh, Zeleke, Ayalew Jejaw, Zenebe, Zerihun Menlkalew, Zhang, Anthony Lin, Zhang, Kai, Zhou, Maigeng, Zodpey, Sanjay, Zuhlke, Liesl Joanna, Naghavi, Mohsen, and Murray, Christopher J. L.
- Abstract
Background: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. GBD 2017 provides a comprehensive assessment of cause-specific mortality for 282 causes in 195 countries and territories from 1980 to 2017. Methods: The causes of death database is composed of vital registration (VR), verbal autopsy (VA), registry, survey, police, and surveillance data. GBD 2017 added ten VA studies, 127 country-years of VR data, 502 cancer-registry country-years, and an additional surveillance country-year. Expansions of the GBD cause of death hierarchy resulted in 18 additional causes estimated for GBD 2017. Newly available data led to subnational estimates for five additional countries—Ethiopia, Iran, New Zealand, Norway, and Russia. Deaths assigned International Classification of Diseases (ICD) codes for non-specific, implausible, or intermediate causes of death were reassigned to underlying causes by redistribution algorithms that were incorporated into uncertainty estimation. We used statistical modelling tools developed for GBD, including the Cause of Death Ensemble model (CODEm), to generate cause fractions and cause-specific death rates for each location, year, age, and sex. Instead of using UN estimates as in previous versions, GBD 2017 independently estimated population size and fertility rate for all locations. Years of life lost (YLLs) were then calculated as the sum of each death multiplied by the standard life expectancy at each age. All rates reported here are age-standardised. Findings: At the broadest grouping of causes of death (Level 1), non-communicable diseases (NCDs) comprised the greatest
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- 2018
122. Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
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Instituto de Salud Carlos III, European Commission, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Junta de Andalucía, Fundación Tatiana Pérez de Guzmán el Bueno, Ministerio de Ciencia, Innovación y Universidades (España), Romero-Molina, Carmen, Navarro-Garrido, Victoria, Sánchez-Varo, Raquel, Jiménez, Sebastián, Fernández-Valenzuela, Juan J., Sánchez-Mico, María V., Muñoz-Castro, Clara, Gutiérrez, Antonia, Vitorica, Javier, Vizuete, Marisa, Instituto de Salud Carlos III, European Commission, Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas (España), Junta de Andalucía, Fundación Tatiana Pérez de Guzmán el Bueno, Ministerio de Ciencia, Innovación y Universidades (España), Romero-Molina, Carmen, Navarro-Garrido, Victoria, Sánchez-Varo, Raquel, Jiménez, Sebastián, Fernández-Valenzuela, Juan J., Sánchez-Mico, María V., Muñoz-Castro, Clara, Gutiérrez, Antonia, Vitorica, Javier, and Vizuete, Marisa
- Abstract
Microglial cells are crucial players in the pathological process of neurodegenerative diseases, such as Alzheimer’s disease (AD). Microglial response in AD has been principally studied in relation to amyloid-beta pathology but, comparatively, little is known about inflammatory processes associated to tau pathology. In the hippocampus of AD patients, where tau pathology is more prominent than amyloid-beta pathology, a microglial degenerative process has been reported. In this work, we have directly compared the microglial response in two different transgenic tau mouse models: ThyTau22 and P301S. Surprisingly, these two models showed important differences in the microglial profile and tau pathology. Where ThyTau22 hippocampus manifested mild microglial activation, P301S mice exhibited a strong microglial response in parallel with high phospho-tau accumulation. This differential phospho-tau expression could account for the different microglial response in these two tau strains. However, soluble (S1) fractions from ThyTau22 hippocampus presented relatively high content of soluble phospho-tau (AT8-positive) and were highly toxic for microglial cells in vitro, whereas the correspondent S1 fractions from P301S mice displayed low soluble phospho-tau levels and were not toxic for microglial cells. Therefore, not only the expression levels but the aggregation of phospho-tau should differ between both models. In fact, most of tau forms in the P301S mice were aggregated and, in consequence, forming insoluble tau species. We conclude that different factors as tau mutations, accumulation, phosphorylation, and/or aggregation could account for the distinct microglial responses observed in these two tau models. For this reason, deciphering the molecular nature of toxic tau species for microglial cells might be a promising therapeutic approach in order to restore the deficient immunological protection observed in AD hippocampus.
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- 2018
123. Abscess formation after transobturator sling placement: a case report
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Colaco, Joao, Goncalves, Vitor, Pinto, Catarina, Castro, Clara, Vieira, Agueda, and Retto, Helio
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- 2007
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124. Expression of BRCA1-associated protein 1 in primary tumors and metastasis in an animal model of uveal melanoma.
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Castro, Clara E., Valdemarin Burnier, Julia, Bergeron, Sabrina, Coblentz, Jacqueline, Beatriz Dias, Ana, and Noel Burnier, Miguel
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UVEA cancer , *METASTASIS , *PROTEIN expression , *MELANOMA , *GENETIC mutation , *ANIMAL models in research - Abstract
Background: Uveal melanoma (UM) is the most common primary intraocular tumor in adults. Despite successful local treatment, approximately 50% of these patients develop lethal metastatic disease. BRCA1-associated protein 1 (BAP1) encodes BAP1, which functions as a tumor suppressor. Inactivation by a somatic mutation in BAP1 results in a loss of protein expression, which is associated with increased risk of metastasis. Aim: To analyze the expression of BAP1 protein in primary uveal tumors and their corresponding metastasis in an animal model of UM and to determine whether BAP1 expression is lost during the metastatic process. Subjects and Methods: Postmortem eyes and lungs with metastasis from nine rabbits previously inoculated with human UM cells expressing BAP1 (92.1 strain) were analyzed. Immunohistochemistry was performed on formalin-fixed paraffin-embedded samples using a monoclonal BAP1 (C-4) antibody. Expression was evaluated by the extent and intensity of staining. All primary tumors and metastasis were positive for BAP1. Results: The staining was diffuse and intense in the primary tumors of four rabbits (67%), focal-intense in one rabbit and focal-mild in one rabbit. All lung metastasis showed focal staining. All animals with intense BAP1 staining in the primary tumor showed mild BAP1 in the metastasis. Discussion: A predominant pattern observed between primary and metastatic lesion shows a transition from moderate into mild intensity and diffuse into the focal extent, suggesting a decrease in BAP1 expression. Future studies, including the human tissue of primary UM and their corresponding metastasis, should be performed to corroborate these findings. [ABSTRACT FROM AUTHOR]
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- 2020
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125. Distinct Microglial Responses in Two Transgenic Murine Models of TAU Pathology
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Romero-Molina, Carmen, primary, Navarro, Victoria, additional, Sanchez-Varo, Raquel, additional, Jimenez, Sebastian, additional, Fernandez-Valenzuela, Juan J., additional, Sanchez-Mico, Maria V., additional, Muñoz-Castro, Clara, additional, Gutierrez, Antonia, additional, Vitorica, Javier, additional, and Vizuete, Marisa, additional
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- 2018
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126. Visceral Obesity and Metabolic Syndrome Are Associated with Well-Differentiated Gastroenteropancreatic Neuroendocrine Tumors
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Santos, Ana, primary, Santos, Ana, additional, Castro, Clara, additional, Raposo, Luís, additional, Pereira, Sofia, additional, Torres, Isabel, additional, Henrique, Rui, additional, Cardoso, Helena, additional, and Monteiro, Mariana, additional
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- 2018
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127. Da organização cartesiana à desorganização sadiana: Sade e o conceito de organização nos séculos XVII e XVIII
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Carnicero de Castro, Clara, primary
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- 2018
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128. Microglia in Alzheimer’s Disease: Activated, Dysfunctional or Degenerative
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Navarro, Victoria, primary, Sanchez-Mejias, Elisabeth, additional, Jimenez, Sebastian, additional, Muñoz-Castro, Clara, additional, Sanchez-Varo, Raquel, additional, Davila, Jose C., additional, Vizuete, Marisa, additional, Gutierrez, Antonia, additional, and Vitorica, Javier, additional
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- 2018
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129. Long-Acting Injectable Atypical Antipsychotic Use in Adolescents: An Observational Study
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Fortea, Adriana, primary, Ilzarbe, Daniel, additional, Espinosa, Laura, additional, Solerdelcoll, Mireia, additional, de Castro, Clara, additional, Oriolo, Giovanni, additional, Sugranyes, Gisela, additional, and Baeza, Inmaculada, additional
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- 2018
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130. AVALIAÇÃO DO DESEMPENHO DOS CONCENTRADOS DE FOSFATOS DE MARROCOS (KHOURIBGA) E DO PERU (BAYÓVAR) NOS ENSAIOS CONTÍNUOS EM MINIPLANTA PILOTO DE ÁCIDO FOSFÓRICO
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Silva, Ruberlan Gomes da, primary, Avelar, Angela Nair, additional, Rodrigues, Sérgio Leite, additional, Cerqueira, Roberto Correa, additional, Smith, Paul Anthony, additional, Soares, Wagner Deonizete, additional, and Castro, Clara Azevedo Mendes de, additional
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- 2018
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131. Molécules malfaisantes, molécules sensibles et molécules organiques : Sade lu d’après Diderot, Buffon et Gassendi
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Castro, Clara, primary
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- 2018
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132. ¿Para cuándo vamos a dejar el porvenir? Formación de excombatientes: una política en construcción
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Ortega Valencia, Piedad, primary, Merchán Díaz, Jeritza, additional, and Castro, Clara, additional
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- 2017
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133. ¿Para cuándo vamos a dejar el porvenir? Formación de excombatientes: una política en construcción
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Ortega Valencia, Piedad, Merchán Díaz, Jeritza, Castro, Clara, Ortega Valencia, Piedad, Merchán Díaz, Jeritza, and Castro, Clara
- Abstract
El presente artículo se compromete en dar cuenta de un análisis del contexto que sitúa el marco general del acuerdo de paz en una dinámica, social y educativa, en la que no se tienen claros los lineamientos y materializaciones de una política pública para el grupo poblacional de excombatientes. De igual modo, atiende a la pregunta ¿desde dónde pensar y agenciar un proyecto de formación para excombatientes de la FARC? Ambos asuntos son reflexionados teniendo como soporte teórico una perspectiva de la pedagogía crítica, que dialoga con la filosofía de la educación, la educación popular y la antropología pedagógica., This article shows an analysis of the context that places the peace agreement general framework in a social and educational dynamic, in which the guidelines and materializations of a public policy for the population group of ex-combatants are not clear. In the same way, it answers the question: from where to think and to organize a training project for the FARC ex-combatants? Both subjects are reflected on having as theoretical support a perspective of critical pedagogy, which dialogues with the philosophy of education, popular education and pedagogical anthropology., Este artigo está empenhado em dar conta de uma análise do contexto que coloca o quadro geral do acordo de paz de forma dinâmica, social e educacional, nas quais as diretrizes e materializações de uma política pública para o grupo populacional de ex- combatentes. Da mesma forma, responde a pergunta: de onde pensar e organizar um projeto de treinamento para ex-combatentes das FARC? Ambos os assuntos se refletem em ter como suporte teórico uma perspectiva de pedagogia crítica, que se diálse com a filosofia da educação, educação popular e antropologia pedagógica.
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- 2017
134. La enseñanza de lengua extranjera en un entorno diferente: inglés en el medio acuático
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Campo Castro, Clara, Jiménez Casado, Alicia, Mezquita Fernández, María Antonia, and Universidad de Valladolid. Facultad de Educación de Segovia
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Inglés (lengua)-Estudio y enseñanza ,Enseñanza bilingüe - Abstract
En el presente trabajo presentamos una propuesta de enseñanza alternativa en el aula de educación infantil. Lejos de utilizar metodologías tradicionales basadas en la instrucción o el trabajo por fichas, nuestra propuesta plantea nuevas formas de enseñar y aprender en el aula a través de metodologías participativas. Para ello, diseñamos una unidad didáctica con propuestas prácticas basadas en el aprendizaje activo y participativo por el método de rincones y grupos interactivos. Aunque esta propuesta no se ha llevado a la práctica sí puede revelar algunos resultados deseados con su desarrollo, como el incremento del grado de autonomía e iniciativa en el proceso por parte del alumnado. Finalmente, concluimos cómo, mediante diferentes modelos de enseñanza basados en metodologías participativas, podría mejorarse el desarrollo personal e íntegro de nuestros alumnos. De nosotros como docentes, depende cómo sea este proceso., Grado en Educación Primaria
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- 2016
135. Glucose metabolism abnormalities and insulin resistance are frequent in well diferentiated digestive NETs
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Santos, Ana P, primary, Santos, Ana C, additional, Castro, Clara, additional, Raposo, Luis, additional, Torres, Isabel, additional, Henrique, Rui, additional, Monteiro, Mariana P, additional, and Cardoso, M Helena, additional
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- 2017
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136. Mechanical And Chemical Factors Required For Maintaining Cardiac Rhythm In Drosophila Melanogaster Larva
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de Castro, Clara, primary, Titlow, Josh, additional, Majeed, Zana R, additional, Malloy, Cole, additional, King, Kayla, additional, and Cooper, Robin, additional
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- 2017
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137. Comorbidities, age and period of diagnosis influence treatment and outcomes in early breast cancer.
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Minicozzi, Pamela, Van Eycken, Liesbet, Molinie, Florence, Innos, Kaire, Guevara, Marcela, Marcos‐Gragera, Rafael, Castro, Clara, Rapiti, Elisabetta, Katalinic, Alexander, Torrella, Ana, Žagar, Tina, Bielska‐Lasota, Magdalena, Giorgi Rossi, Paolo, Larrañaga, Nerea, Bastos, Joana, Sánchez, Maria José, and Sant, Milena
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Survival for breast cancer (BC) is lower in eastern than northern/central Europe, and in older than younger women. We analysed how comorbidities at diagnosis affected whether selected standard treatments (STs) were given, across Europe and over time, also assessing consequences for survival/relapse. We analysed 7581 stage I/IIA cases diagnosed in 9 European countries in 2009–2013, and 4 STs: surgery; breast‐conserving surgery plus radiotherapy (BCS + RT); reconstruction after mastectomy; and prompt treatment (≤6 weeks after diagnosis). Covariate‐adjusted models estimated odds of receiving STs and risks of death/relapse, according to comorbidities. Pearson's R assessed correlations between odds and risks. The z‐test assessed the significance of time‐trends. Most women received surgery: 72% BCS; 24% mastectomy. Mastectomied patients were older with more comorbidities than BCS patients (p < 0.001). Women given breast reconstruction (25% of mastectomies) were younger with fewer comorbidities than those without reconstruction (p < 0.001). Women treated promptly (45%) were younger than those treated later (p = 0.001), and more often without comorbidities (p < 0.001). Receiving surgery/BCS + RT correlated strongly (R = −0.9), but prompt treatment weakly (R = −0.01/−0.02), with reduced death/relapse risks. The proportion receiving BCS + RT increased significantly (p < 0.001) with time in most countries. This appears to be the first analysis of the influence of comorbidities on receiving STs, and of consequences for outcomes. Increase in BCS + RT with time is encouraging. Although women without comorbidities usually received STs, elderly patients often received non‐standard less prompt treatments, irrespective of comorbidities, with increased risk of mortality/relapse. All women, particularly the elderly, should receive ST wherever possible to maximise the benefits of modern evidence‐based treatments. What's new?: This is the first Europe‐wide study (37 cancer registries, 9 countries) analysing the effect of comorbidities on whether women with early breast cancer (diagnosed 2009–13) receive standard treatments. Women with no comorbidities usually received standard treatments, but elderly women often received less prompt and non‐standard treatments, irrespective of comorbidities, with increased probability of relapse and mortality. All women, particularly the elderly, should receive standard treatments wherever possible to maximize the benefits of modern evidence‐based approaches. [ABSTRACT FROM AUTHOR]
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- 2019
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138. Paravertebral block for management of acute postoperative pain and intercostobrachial neuralgia in major breast surgery
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Gacio, Mercedes Fernández, Lousame, Ana Maria Agrelo, Pereira, Susana, Castro, Clara, and Santos, Juliana
- Abstract
Several locoregional techniques have been described for the management of acute and chronic pain after breast surgery. The optimal technique should be easy to perform, reproducible, with little discomfort to the patient, little complications, allowing good control of acute pain and a decreased incidence of chronic pain, namely intercostobrachial neuralgia for being the most frequent entity.
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- 2024
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139. Plan de mercadeo para la empresa Protech Epp en el sector de comercialización de productos de seguridad industrial en la ciudad de Villavicencio-Meta
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Ramírez Castro, Clara Liseth and Ramírez Castro, Clara Liseth
- Abstract
El presente documento tiene como objetivo el diseño de una estrategia de Mercadeo que permita aumentar las ventas de la comercializadora PROTECH e.p.p., teniendo en cuenta la mezcla del Marketing Mix y el posicionamiento estratégico para el desarrollo de dicha estrategia. A través del desarrollo de la investigación y de acuerdo a la investigación realizada, se desarrolla una estrategia de Mercadeo bajo un entorno investigativo y en un lineamiento dinámico, generando valor agregado y acciones tácticas de tal manera que se logre incrementar las utilidades logrando así una migración del marketing transaccional a un gestión de Marketing relacional bajo un enfoque de valor agregado y dinamismo, involucrando a los integrantes del clúster del sector elementos de Protección Personal y de seguridad Industrial .
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- 2016
140. La revolución como metáfora política: para una comprensión de la revolución fascista de Benito Mussolini
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Franco Castro, Clara del Pilar
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Asumiendo que existe una tendencia de la opinión pública y académica por relacionar la idea de revolución con procesos netamente de izquierda, se propone comprender el término como concepto y como metáfora con el fin de alejarlo de la polarización ideológica. En esta investigación se abordan los conceptos políticos y su relación con las metáforas a partir de unos principios teóricos básicos: la idea de Koselleck de que los conceptos tienen historia, y la idea de Blumenberg de que muchos conceptos fundamentales son potentes porque en el fondo son metáforas. Posteriormente se observa cómo las diferentes posturas políticas han adoptado o rechazado la idea de revolución como parte de sus proyectos políticos. Finalmente, el caso del fascismo se presenta como un escenario clave para comprobar la trascendencia del concepto y las implicaciones de su uso en términos discursivos y prácticos
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- 2014
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141. Initial assessment of patients without cognitive failure admitted to palliative care: a validation study
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Ferraz Gonçalves, José António, primary, Castro, Clara, additional, Silva, Paula, additional, Carneiro, Rui, additional, Simões, Catarina, additional, and Costa, Isabel, additional
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- 2016
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142. Bloqueio paravertebral no controle da dor aguda pós‐operatória e dor neuropática do nervo intercostobraquial em cirurgia mamária de grande porte
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Gacio, Mercedes Fernández, primary, Lousame, Ana Maria Agrelo, additional, Pereira, Susana, additional, Castro, Clara, additional, and Santos, Juliana, additional
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- 2016
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143. Trends in Gastric and Esophageal Cancer Incidence in Northern Portugal (1994-2009) by Subsite and Histology, and Predictions for 2015
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Castro, Clara, primary, Peleteiro, Bárbara, additional, Bento, Maria José, additional, and Lunet, Nuno, additional
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- 2016
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144. Worldwide burden of gastric cancer in 2010 attributable to high sodium intake in 1990 and predicted attributable burden for 2030 based on exposures in 2010
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Peleteiro, Bárbara, primary, Barros, Susana, additional, Castro, Clara, additional, Ferro, Ana, additional, Morais, Samantha, additional, and Lunet, Nuno, additional
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- 2016
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145. Worldwide burden of gastric cancer in 2012 that could have been prevented by increasing fruit and vegetable intake and predictions for 2025
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Peleteiro, Bárbara, primary, Padrão, Patrícia, additional, Castro, Clara, additional, Ferro, Ana, additional, Morais, Samantha, additional, and Lunet, Nuno, additional
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- 2016
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146. Proyecto de restauración del Quiosco de Música del Paseo del Bombé en el Parque de San Francisco de Oviedo
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Rey-Stolle Castro, Clara and Rey-Stolle Castro, Clara
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- 2015
147. Buenaventura: un puerto sin comunidad
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Millán Echeverría, Constanza; Serrato Martínez, Ludivia; Pérez, Oscar; Castro, Clara, Centro Nacional de Memoria Histórica, Millán Echeverría, Constanza; Serrato Martínez, Ludivia; Pérez, Oscar; Castro, Clara, and Centro Nacional de Memoria Histórica
- Abstract
En este informe investigadoras e investigadores del Centro Nacional de Memoria Histórica, en colaboración con un grupo de organizaciones sociales, étnicas y eclesiales de la región, analizan desde una perspectiva de memoria histórica en el periodo que va de 2000 a 2013, ¿cómo se ha conformado en este territorio un contexto que ha favorecido que grupos armados ilegales continúen ejecutando modalidades de victimización altamente degradadas hacia la población afrodescendiente, pese a los acuerdos de desmovilización establecidos en 2004 entre el Gobierno nacional y el Bloque Calima de las AUC?, ¿cuál es la lógica que subyace en la interrelación de diversas modalidades de victimización en este territorio urbano del Pacífico como desplazamientos forzados, homicidios, desapariciones forzadas, reclutamiento forzado a niños y niñas, abuso y acoso sexual a mujeres, enfrentamientos armados, asesinatos a líderes y lideresas, conformación de espacios de tortura y de cementerios clandestinos? También, ¿qué significados y sentidos han otorgado las comunidades afrodescendientes urbanas a los diferentes periodos de disputa territorial que han vivido desde el año 2000? ¿Cómo han otorgado signifcado a los daños producidos en sus trayectorias vitales por los contextos de victimización? Y ¿cómo la población ha conjurado plurales y creativos escenarios de resistencia para continuar habitando el territorio urbano pese a la imposición en el orden social de los repertorios violentos de desterritorialización, terror e invisibilización?, INFORME DEL CENTRO NACIONAL DE MEMORIA HISTÓRICA Buenaventura: un puerto sin comunidad Buenaventura: un puerto sin comunidad Buenaventura: un puerto sin comunidad Director General del CentroNacional de Memoria Histórica Gonzalo Sánchez Gómez Coordinadora y relatora de la inves-tigación Constanza Millán Echeverría Investigadores e investigadoras Ludivia Serrato Martínez Oscar Pérez Clara Castro Investigadores locales Danelly Estupiñán Pbro. Adriel Ruiz Asistentes de investigación Jenny Salcedo Oscar Segura Jairo González Auxiliares de investigación Patricia Molina Jairo Ortegón Lina Gaitán Mónica Iza Julie Criales Érika Sepúlveda CONSEJO DIRECTIVO CENTRO NACIONAL DE MEMORIA HISTÓRICA Presidenta Tatyana Orozco de la Cruz Directora del Departamento para la Prosperidad Social Mariana Garcés Córdoba Ministra de Cultura Gina Parody d’Echeona Ministra de Educación Nacional Yesid Reyes Alvarado Ministro de Justicia y del Derecho Paula Gaviria Betancur Directora de la Unidad para la Atención y Reparación Integral a las Víctimas Félix Tomás Batta Jiménez Blanca Berta Rodríguez Peña Representantes de víctimas CENTRO NACIONAL DE MEMORIA HISTÓRICA Gonzalo Sánchez Gómez Director General Andrés Fernando Suárez, Patricia Lina-res Prieto, María Emma Wills Obregón, Paula Andrea Ila, Doris Yolanda Ramos Vega, César Augusto Rincón Vicentes Asesores de Dirección Directores técnicos Camila Medina Arbeláez Dirección para la Construcción de la Memoria Histórica Álvaro Villarraga Sarmiento Dirección de Acuerdos de la Verdad Ana Margoth Guerrero de Otero Dirección de Archivo de los Derechos Humanos Martha Nubia Bello Albarracín Dirección de Museo de la Memoria Janeth Cecilia Camacho Márquez Dirección Administrativa y Financiera Adriana Correa Mazuera Coordinación Equipo de Comunicaciones Buenaventura: un puerto sin comunidad isbn: 978-958-58887-4-6 Primera edición: junio de 2015 Número de páginas: 484 Formato: 15 x 23 cm Coordinación editorial: Tatiana Peláez Acevedo Edición y corrección de
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- 2015
148. AVALIAÇÃO DO DESEMPENHO DOS CONCENTRADOS DE FOSFATOS DE MARROCOS (KHOURIBGA) E DO PERU (BAYÓVAR) NOS ENSAIOS CONTÍNUOS EM MINIPLANTA PILOTO DE ÁCIDO FOSFÓRICO.
- Author
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Gomes da Silva, Ruberlan, Nair Avelar, Angela, Leite Rodrigues, Sérgio, Correa Cerqueira, Roberto, Smith, Paul Anthony, Deonizete Soares, Wagner, and Mendes de Castro, Clara Azevedo
- Abstract
Copyright of Tecnologia em Metalurgia, Materiais e Mineração is the property of Associacao Brasileira de Metalurgia e Materiais and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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- 2018
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149. An explanatory and predictive model of the variation in esophageal cancer incidence on the basis of changes in the exposure to risk factors.
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Castro, Clara, Peleteiro, Bárbara, Morais, Samantha, Severo, Milton, Bento, Maria José, and Lunet, Nuno
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- 2018
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150. Modifiable factors and esophageal cancer: a systematic review of published meta-analyses.
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Castro, Clara, Peleteiro, Bárbara, and Lunet, Nuno
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ESOPHAGEAL cancer , *CANCER risk factors , *EPIDEMIOLOGY , *PUBLIC health , *META-analysis , *ADENOCARCINOMA - Abstract
There are marked differences in the etiology of the major histological types of esophageal cancer (EC)-squamous cell carcinomas (ESCC) and adenocarcinomas (EAC). This study aimed to summarize the current scientific knowledge on modifiable risk factors for EC, by histological type, through a systematic review of meta-analyses referenced in PubMed and ISI Web of Knowledge. We identified 100 meta-analyses on risk factors for ESCC (n = 54), EAC (n = 43), or EC (n = 51). ESCC risk significantly increased with alcohol and maté drinking, smoking, red and processed meat consumption and human papillomavirus infection, while it was negatively associated with body mass index and consumption of fruit, vegetables, white meat, folate, and some carotenoids. Cessation of drinking and smoking significantly reduced ESCC risk. For EAC, an increased risk was reported for smoking, body mass index, and red and processed meat consumption, while risk decreased with Helicobacter pylori infection, low/moderate alcohol drinking, physical activity, and consumption of fruit, vegetables, folate, fiber, beta-carotene, and vitamin C. Differences in results between meta-analyses and mechanisms underlying some of the associations found are discussed. This work reinforces the importance of a separate assessment of EC subtypes to allow for a proper evaluation of incidence trends and planning of prevention/control interventions. [ABSTRACT FROM AUTHOR]
- Published
- 2018
- Full Text
- View/download PDF
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