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147 results on '"Castren, Eero"'

101. Mice with altered BDNF signaling as models for mood disorders and antidepressant effects

Author

Lindholm, Jesse S. O., Castren, Eero, and Neuroscience Center

Subjects
behavior, CHEMICAL-GENETIC APPROACH, VAL66MET POLYMORPHISM, education, 3112 Neurosciences, MAJOR DEPRESSION, RAT DENTATE GYRUS, neurotrophins, BDNF, NEUROTROPHIC FACTOR EXPRESSION, SOCIAL DEFEAT STRESS, depression, HIPPOCAMPAL FUNCTION, BEHAVIORAL-MODELS, TrkB signaling, Bdnf deficient mice, LONG-TERM POTENTIATION, transgenic, FACTOR-RECEPTOR TRKB
Published
2014

102. Ciliary dyslexia candidate genes DYX1C1 and DCDC2 are regulated by Regulatory Factor X (RFX) transcription factors through X‐box promoter motifs

Author

Tammimies, Kristiina, primary, Bieder, Andrea, additional, Lauter, Gilbert, additional, Sugiaman‐Trapman, Debora, additional, Torchet, Rachel, additional, Hokkanen, Marie‐Estelle, additional, Burghoorn, Jan, additional, Castren, Eero, additional, Kere, Juha, additional, Tapia‐Páez, Isabel, additional, and Swoboda, Peter, additional

Published
2016
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103. Neuronal Network Plasticity and Recovery From Depression

Author

Castren, Eero and Neuroscience Center

Subjects
OCULAR DOMINANCE PLASTICITY, education, CENTRAL-NERVOUS-SYSTEM, PSYCHIATRIC-DISORDERS, LATE-LIFE DEPRESSION, 3112 Neurosciences, ADULT BRAIN PLASTICITY, WHITE-MATTER ABNORMALITIES, RANDOMIZED CONTROLLED-TRIAL, VISUAL-CORTEX, NEUROTROPHIC FACTOR, HEALTHY-VOLUNTEERS
Published
2013

108. TrkB overexpression in mice buffers against memory deficits and depression-like behavior but not all anxiety- and stress-related symptoms induced by developmental exposure to methylmercury

Author

University of Helsinki, Neuroscience Center, Karpova, Nina N., Lindholm, Jesse Saku Olavi, Kulesskaya, Natalia, Onishchenko, Natalia, Vahter, Marie, Popova, Dina, Ceccatelli, Sandra, Castren, Eero, University of Helsinki, Neuroscience Center, Karpova, Nina N., Lindholm, Jesse Saku Olavi, Kulesskaya, Natalia, Onishchenko, Natalia, Vahter, Marie, Popova, Dina, Ceccatelli, Sandra, and Castren, Eero

Published
2014

110. Utilization of in situ ELISA method for examining Trk receptor phosphorylation in cultured cells

Author

University of Helsinki, Neuroscience Center, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Faculty of Pharmacy, Antila, Hanna, Autio, Henri, Turunen, Laura, Harju, Kirsi, Tammela, Paivi, Wennerberg, Krister, Yli-Kauhaluoma, Jari, Huttunen, Henri J., Castren, Eero, Rantamaki, Tomi, University of Helsinki, Neuroscience Center, University of Helsinki, Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Faculty of Pharmacy, Antila, Hanna, Autio, Henri, Turunen, Laura, Harju, Kirsi, Tammela, Paivi, Wennerberg, Krister, Yli-Kauhaluoma, Jari, Huttunen, Henri J., Castren, Eero, and Rantamaki, Tomi

Published
2014

111. Combination of fluoxetine and extinction treatments forms a unique synaptic protein profile that correlates with long-term fear reduction in adult mice

Author

University of Helsinki, Neuroscience Center, Popova, Dina, Agustsdottir, Arna, Lindholm, Jesse, Mazulis, Warns, Akamine, Yumiko, Castren, Eero, Karpova, Nina N., University of Helsinki, Neuroscience Center, Popova, Dina, Agustsdottir, Arna, Lindholm, Jesse, Mazulis, Warns, Akamine, Yumiko, Castren, Eero, and Karpova, Nina N.

Published
2014

112. Gene Expression Patterns Underlying the Reinstatement of Plasticity in the Adult Visual System

Author

University of Helsinki, Neuroscience Center, University of Helsinki, Institute of Biotechnology, Tiraboschi, Ettore, Guirado, Ramon, Greco, Dario, Auvinen, Petri, Fernando Maya-Vetencourt, Jose, Maffei, Lamberto, Castren, Eero, University of Helsinki, Neuroscience Center, University of Helsinki, Institute of Biotechnology, Tiraboschi, Ettore, Guirado, Ramon, Greco, Dario, Auvinen, Petri, Fernando Maya-Vetencourt, Jose, Maffei, Lamberto, and Castren, Eero

Published
2013

113. The Responsiveness of TrkB to BDNF and Antidepressant Drugs Is Differentially Regulated during Mouse Development

Author

University of Helsinki, Neuroscience Center, Di Lieto, Antonio, Rantamaki, Tomi, Vesa, Liisa, Yanpallewar, Sudhirkumar, Antila, Hanna, Lindholm, Jesse, Rios, Maribel, Tessarollo, Lino, Castren, Eero, University of Helsinki, Neuroscience Center, Di Lieto, Antonio, Rantamaki, Tomi, Vesa, Liisa, Yanpallewar, Sudhirkumar, Antila, Hanna, Lindholm, Jesse, Rios, Maribel, Tessarollo, Lino, and Castren, Eero

Published
2012

115. Increased Expression of the Dyslexia Candidate Gene DCDC2 Affects Length and Signaling of Primary Cilia in Neurons

Author

Massinen, Satu, Hokkanen, Marie-Estelle, Matsson, Hans, Tammimies, Kristiina, Tapia-Paez, Isabel, Dahlstrom-Heuser, Vanina, Kuja-Panula, Juha, Burghoorn, Jan, Jeppsson, Kristian E., Swoboda, Peter, Peyrard-Janvid, Myriam, Toftgard, Rune, Castren, Eero, Kere, Juha, Massinen, Satu, Hokkanen, Marie-Estelle, Matsson, Hans, Tammimies, Kristiina, Tapia-Paez, Isabel, Dahlstrom-Heuser, Vanina, Kuja-Panula, Juha, Burghoorn, Jan, Jeppsson, Kristian E., Swoboda, Peter, Peyrard-Janvid, Myriam, Toftgard, Rune, Castren, Eero, and Kere, Juha

Abstract

DCDC2 is one of the candidate susceptibility genes for dyslexia. It belongs to the superfamily of doublecortin domain containing proteins that bind to microtubules, and it has been shown to be involved in neuronal migration. We show that the Dcdc2 protein localizes to the primary cilium in primary rat hippocampal neurons and that it can be found within close proximity to the ciliary kinesin-2 subunit Kif3a. Overexpression of DCDC2 increases ciliary length and activates Shh signaling, whereas downregulation of Dcdc2 expression enhances Wnt signaling, consistent with a functional role in ciliary signaling. Moreover, DCDC2 overexpression in C. elegans causes an abnormal neuronal phenotype that can only be seen in ciliated neurons. Together our results suggest a potential role for DCDC2 in the structure and function of primary cilia.

Published
2011
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116. Physiology, pathology and relatedness of human tissues from gene expression meta-analysis

Author

University of Helsinki, Institute of Biotechnology (-2009), University of Helsinki, Department of Biosciences, University of Helsinki, Neuroscience center (-2009), Greco, Dario, Somervuo, Panu, Di Lieto, Antonio, Raitila, Tuomas, Nitsch, Lucio, Castren, Eero, Auvinen, Petri, University of Helsinki, Institute of Biotechnology (-2009), University of Helsinki, Department of Biosciences, University of Helsinki, Neuroscience center (-2009), Greco, Dario, Somervuo, Panu, Di Lieto, Antonio, Raitila, Tuomas, Nitsch, Lucio, Castren, Eero, and Auvinen, Petri

Published
2008

123. Brain-Derived Neurotrophic Factor Controls Activity-Dependent Maturation of CA1S ynapses by Downregulating Tonic Activation of Presynaptic Kainate Receptors.

Author

Sallert, Marko, Rantamäki, Tomi, Vesikansa, Aino, Anthoni, Heidi, Harju, Kirsi, Yli-Kauhaluoma, Jari, Taira, Tomi, Castren, Eero, and Lauri, Sari E.

Subjects
SYNAPSES, BRAIN research, NEURAL transmission, NEUROPHYSIOLOGY, GLUTAMIC acid
Abstract

Immature hippocampal synapses express presynaptic kainate receptors (KARs), which tonically inhibit glutamate release. Presynaptic maturation involves activity-dependent downregulation of the tonic KAR activity and consequent increase in release probability; however, the molecular mechanisms underlying this developmental process are unknown. Here, we have investigated whether brain derived neurotrophic factor (BDNF), a secreted protein implicated in developmental plasticity in several areas of the brain, controls presynaptic maturation by regulating KARs. Application of BDNF in neonate hippocampal slices resulted in increase in synaptic transmission that fully occluded the immaturetype KAR activity in area CA1. Conversely, genetic ablation of BDNF was associated with delayed synaptic maturation and persistent presynaptic KAR activity, suggesting a role for endogenous BDNF in the developmental regulation of KAR function. In addition, our data suggests a critical role for BDNF TrkB signaling in fast activity-dependent regulation of KARs. Selective acute inhibition of TrkB receptors using a chemical-genetic approach prevented rapid change in synapse dynamics and loss of tonic KAR activity that is typically seen in response to induction of LTP at immature synapses. Together, these data show that BDNF-TrkB-dependent maturation of glutamatergic synapses is tightly associated with a loss of endogenous KAR activity. The coordinated action of these two receptor mechanisms has immediate physiological relevance in controlling presynaptic efficacy and transmission dynamics at CA3-CA1 synapses at a stage of development when functional contact already exists but transmission is weak. [ABSTRACT FROM AUTHOR]

Published
2009
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125. Activation of the TrkB Neurotrophin Receptor Is Induced by Antidepressant Drugs and Is Required for Antidepressant-Induced Behavioral Effects.

Author

Saarelainen, Tommi, Hendolin, Panu, Lucas, Guilherme, Koponen, Eija, Sairanen, Mikko, MacDonald, Ewen, Agerman, Karin, Haapasalo, Annakaisa, Nawa, Hiroyuki, Aloyz, Raquel, Ernfors, Patrik, and Castren, Eero

Subjects
CELL receptors, ANTIDEPRESSANTS, HIPPOCAMPUS (Brain), CEREBRAL cortex, SEROTONIN, PHOSPHORYLATION, CHEMICAL reactions
Abstract

Presents a study which investigated the role of endogenous brain-derived neutrophic factor (BDNF) and its receptor trkB in the mechanism of action of antidepressant drugs. Effect of antidepressant drugs in the signaling of serotonin or norepinephrine; Materials and methods used; Result of the infusion of BDNF into hippocampus or mid-brain area; Correlation between antidepressant treatment and trkB autophosphorylation.

Published
2003
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147. Contributors to Volume 17

Author

Blatteis, Clark M., Bluthe, Rose-Marie, Busbridge, Nicholas J., Castrén, Eero, Catania, Anna, Dantzer, Robert, de Sarro, Giovambattista, Dunn, Adrian J., Fisher, Stephen N., Goodall, Glyn, Gorospe, William C., Griffin, W. Sue T., Hengerer, Bastian, Hughes, Francis M., Jr., Kapás, Levente, Kent, Stephen, Kimura, Mayumi, Krueger, James M., Lieberman, Andrew P., Lindholm, Dan, Lipton, James M., MacLeod, Robert M., Marshak, Daniel R., Martínez-Maza, Otoniel, Merrill, Jean E., Nisticò, Giuseppe, Opp, Mark R., Plata-Salamán, Carlos R., Rothwell, Nancy J., Rotiroti, Domenicantonio, Rovnaghi, Cynthia R., Saperas, Esteban, Shin, Moon L., Spangelo, Bryan L., Stanley, Laura C., Sundar, Syam K., Taché, Yvette, Weiss, Jay M., and Yeralan, Olcay

Published
1993
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