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103. The homozygous K280N troponin T mutation alters cross-bridge kinetics and energetics in human HCM

105. Treatments targeting inotropy

107. Familial Hypertrophic Cardiomyopathy: Microsatellite Haplotyping and Identification of a Hot Spot for Mutations in the Beta-Myosin Heavy Chain Gene

111. CRISPR/Cas9 editing in human pluripotent stem cell-cardiomyocytes highlights arrhythmias, hypocontractility, and energy depletion as potential therapeutic targets for hypertrophic cardiomyopathy

114. Evaluation of MYBPC3 trans -Splicing and Gene Replacement as Therapeutic Options in Human iPSC-Derived Cardiomyocytes

115. Blinded Contractility Analysis in hiPSC-Cardiomyocytes in Engineered Heart Tissue Format: Comparison With Human Atrial Trabeculae

118. The embryological basis of subclinical hypertrophic cardiomyopathy

119. S ‐glutathiolation impairs phosphoregulation and function of cardiac myosin‐binding protein C in human heart failure

122. Abstract 19161: cAMP Regulated Transcriptional Coactivator 1 - A Novel Player in Cardiac Hypertrophy

123. Ranolazine antagonizes catecholamine-induced dysfunction in isolated cardiomyocytes, but lacks long-term therapeutic effectsin vivoin a mouse model of hypertrophic cardiomyopathy

124. PLEKHM2mutation leads to abnormal localization of lysosomes, impaired autophagy flux and associates with recessive dilated cardiomyopathy and left ventricular noncompaction

125. Targeted Mybpc3 Knock-Out Mice with Cardiac Hypertrophy Exhibit Structural Mitral Valve Abnormalities

127. Changes in the cardiac metabolome caused by perhexiline treatment in a mouse model of hypertrophic cardiomyopathy

128. Atrogin-1 and MuRF1 regulate cardiac MyBP-C levels via different mechanisms

129. Endothelin‐1 Induces Myofibrillar Disarray and Contractile Vector Variability in Hypertrophic Cardiomyopathy–Induced Pluripotent Stem Cell–Derived Cardiomyocytes

131. Mybpc3 gene therapy for neonatal cardiomyopathy enables long-term disease prevention in mice

132. Epigallocatechin-3-Gallate Accelerates Relaxation and Ca2+ Transient Decay and Desensitizes Myofilaments in Healthy and Mybpc3-Targeted Knock-in Cardiomyopathic Mice.

135. Automated analysis of contractile force and Ca2+transients in engineered heart tissue

138. Contractile abnormalities and altered drug response in engineered heart tissue from Mybpc3-targeted knock-in mice

139. The expression of podocyte-specific proteins in parietal epithelial cells is regulated by protein degradation

140. Perturbed Length-Dependent Activation in Human Hypertrophic Cardiomyopathy With Missense Sarcomeric Gene Mutations

141. Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP)-mediated Calcium Signaling and Arrhythmias in the Heart Evoked by β-Adrenergic Stimulation

143. GSK3β Phosphorylates Newly Identified Site in the Proline-Alanine–Rich Region of Cardiac Myosin–Binding Protein C and Alters Cross-Bridge Cycling Kinetics in Human

144. Distinctive Serum miRNA Profile in Mouse Models of Striated Muscular Pathologies

145. The HCM-Associated Cardiac Troponin T Mutation K280N Increases the Energetic Cost of Tension Generation in Human Cardiac Myofibrils

146. Repair of Mybpc3 mRNA by 5′-trans-splicing in a Mouse Model of Hypertrophic Cardiomyopathy

147. Selective phosphorylation of PKA targets after β-adrenergic receptor stimulation impairs myofilament function in Mybpc3-targeted HCM mouse model.

148. Knock-out of nexilin in mice leads to dilated cardiomyopathy and endomyocardial fibroelastosis.

150. Pharmacological Characterization of 1-Nitrosocyclohexyl Acetate, a Long-Acting Nitroxyl Donor That Shows Vasorelaxant and Antiaggregatory Effects

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