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101. LOGGIC Core BioClinical Data Bank: Added clinical value of RNA-Seq in an international molecular diagnostic registry for pediatric low-grade glioma patients

Author

Hardin, Emily C, primary, Schmid, Simone, additional, Sommerkamp, Alexander, additional, Bodden, Carina, additional, Heipertz, Anna-Elisa, additional, Sievers, Philipp, additional, Wittmann, Andrea, additional, Milde, Till, additional, Pfister, Stefan M, additional, von Deimling, Andreas, additional, Horn, Svea, additional, Herz, Nina A, additional, Simon, Michèle, additional, Perera, Ashwyn A, additional, Azizi, Amedeo, additional, Cruz, Ofelia, additional, Curry, Sarah, additional, Van Damme, An, additional, Garami, Miklos, additional, Hargrave, Darren, additional, Kattamis, Antonis, additional, Kotnik, Barbara Faganel, additional, Lähteenmäki, Päivi, additional, Scheinemann, Katrin, additional, Schouten-van Meeteren, Antoinette Y N, additional, Sehested, Astrid, additional, Viscardi, Elisabetta, additional, Wormdal, Ole Mikal, additional, Zapotocky, Michal, additional, Ziegler, David S, additional, Koch, Arend, additional, Driever, Pablo Hernáiz, additional, Witt, Olaf, additional, Capper, David, additional, Sahm, Felix, additional, Jones, David T W, additional, and van Tilburg, Cornelis M, additional

Published
2023
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102. Data from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

Author

Zheng, Tuyu, primary, Ghasemi, David R., primary, Okonechnikov, Konstantin, primary, Korshunov, Andrey, primary, Sill, Martin, primary, Maass, Kendra K., primary, Benites Goncalves da Silva, Patricia, primary, Ryzhova, Marina, primary, Gojo, Johannes, primary, Stichel, Damian, primary, Arabzade, Amir, primary, Kupp, Robert, primary, Benzel, Julia, primary, Taya, Shinichiro, primary, Adachi, Toma, primary, Shiraishi, Ryo, primary, Gerber, Nicolas U., primary, Sturm, Dominik, primary, Ecker, Jonas, primary, Sievers, Philipp, primary, Selt, Florian, primary, Chapman, Rebecca, primary, Haberler, Christine, primary, Figarella-Branger, Dominique, primary, Reifenberger, Guido, primary, Fleischhack, Gudrun, primary, Rutkowski, Stefan, primary, Donson, Andrew M., primary, Ramaswamy, Vijay, primary, Capper, David, primary, Ellison, David W., primary, Herold-Mende, Christel C., primary, Schüller, Ulrich, primary, Brandner, Sebastian, primary, Driever, Pablo Hernáiz, primary, Kros, Johan M., primary, Snuderl, Matija, primary, Milde, Till, primary, Grundy, Richard G., primary, Hoshino, Mikio, primary, Mack, Stephen C., primary, Gilbertson, Richard J., primary, Jones, David T.W., primary, Kool, Marcel, primary, von Deimling, Andreas, primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Kawauchi, Daisuke, primary, and Pajtler, Kristian W., primary

Published
2023
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103. Data from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations

Author

Wang, Anthony C., primary, Jones, David T.W., primary, Abecassis, Isaac Joshua, primary, Cole, Bonnie L., primary, Leary, Sarah E.S., primary, Lockwood, Christina M., primary, Chavez, Lukas, primary, Capper, David, primary, Korshunov, Andrey, primary, Fallah, Aria, primary, Wang, Shelly, primary, Ene, Chibawanye, primary, Olson, James M., primary, Geyer, J. Russell, primary, Holland, Eric C., primary, Lee, Amy, primary, Ellenbogen, Richard G., primary, and Ojemann, Jeffrey G., primary

Published
2023
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104. Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
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105. Supplementary Table from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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106. Supplementary Table S4 from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

Author

Zheng, Tuyu, primary, Ghasemi, David R., primary, Okonechnikov, Konstantin, primary, Korshunov, Andrey, primary, Sill, Martin, primary, Maass, Kendra K., primary, Benites Goncalves da Silva, Patricia, primary, Ryzhova, Marina, primary, Gojo, Johannes, primary, Stichel, Damian, primary, Arabzade, Amir, primary, Kupp, Robert, primary, Benzel, Julia, primary, Taya, Shinichiro, primary, Adachi, Toma, primary, Shiraishi, Ryo, primary, Gerber, Nicolas U., primary, Sturm, Dominik, primary, Ecker, Jonas, primary, Sievers, Philipp, primary, Selt, Florian, primary, Chapman, Rebecca, primary, Haberler, Christine, primary, Figarella-Branger, Dominique, primary, Reifenberger, Guido, primary, Fleischhack, Gudrun, primary, Rutkowski, Stefan, primary, Donson, Andrew M., primary, Ramaswamy, Vijay, primary, Capper, David, primary, Ellison, David W., primary, Herold-Mende, Christel C., primary, Schüller, Ulrich, primary, Brandner, Sebastian, primary, Driever, Pablo Hernáiz, primary, Kros, Johan M., primary, Snuderl, Matija, primary, Milde, Till, primary, Grundy, Richard G., primary, Hoshino, Mikio, primary, Mack, Stephen C., primary, Gilbertson, Richard J., primary, Jones, David T.W., primary, Kool, Marcel, primary, von Deimling, Andreas, primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Kawauchi, Daisuke, primary, and Pajtler, Kristian W., primary

Published
2023
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107. Supplementary Data from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
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108. Data from Targeting the BRAF V600E Mutation in Multiple Myeloma

Author

Andrulis, Mindaugas, primary, Lehners, Nicola, primary, Capper, David, primary, Penzel, Roland, primary, Heining, Christoph, primary, Huellein, Jennifer, primary, Zenz, Thorsten, primary, von Deimling, Andreas, primary, Schirmacher, Peter, primary, Ho, Anthony D., primary, Goldschmidt, Hartmut, primary, Neben, Kai, primary, and Raab, Marc S., primary

Published
2023
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109. Table S1 from Desmoplastic Infantile Ganglioglioma/Astrocytoma (DIG/DIA) Are Distinct Entities with Frequent BRAFV600 Mutations

Author

Wang, Anthony C., primary, Jones, David T.W., primary, Abecassis, Isaac Joshua, primary, Cole, Bonnie L., primary, Leary, Sarah E.S., primary, Lockwood, Christina M., primary, Chavez, Lukas, primary, Capper, David, primary, Korshunov, Andrey, primary, Fallah, Aria, primary, Wang, Shelly, primary, Ene, Chibawanye, primary, Olson, James M., primary, Geyer, J. Russell, primary, Holland, Eric C., primary, Lee, Amy, primary, Ellenbogen, Richard G., primary, and Ojemann, Jeffrey G., primary

Published
2023
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110. Supplementary Table S3 from Infant High-Grade Gliomas Comprise Multiple Subgroups Characterized by Novel Targetable Gene Fusions and Favorable Outcomes

Author

Clarke, Matthew, primary, Mackay, Alan, primary, Ismer, Britta, primary, Pickles, Jessica C., primary, Tatevossian, Ruth G., primary, Newman, Scott, primary, Bale, Tejus A., primary, Stoler, Iris, primary, Izquierdo, Elisa, primary, Temelso, Sara, primary, Carvalho, Diana M., primary, Molinari, Valeria, primary, Burford, Anna, primary, Howell, Louise, primary, Virasami, Alex, primary, Fairchild, Amy R., primary, Avery, Aimee, primary, Chalker, Jane, primary, Kristiansen, Mark, primary, Haupfear, Kelly, primary, Dalton, James D., primary, Orisme, Wilda, primary, Wen, Ji, primary, Hubank, Michael, primary, Kurian, Kathreena M., primary, Rowe, Catherine, primary, Maybury, Mellissa, primary, Crosier, Stephen, primary, Knipstein, Jeffrey, primary, Schüller, Ulrich, primary, Kordes, Uwe, primary, Kram, David E., primary, Snuderl, Matija, primary, Bridges, Leslie, primary, Martin, Andrew J., primary, Doey, Lawrence J., primary, Al-Sarraj, Safa, primary, Chandler, Christopher, primary, Zebian, Bassel, primary, Cairns, Claire, primary, Natrajan, Rachael, primary, Boult, Jessica K.R., primary, Robinson, Simon P., primary, Sill, Martin, primary, Dunkel, Ira J., primary, Gilheeney, Stephen W., primary, Rosenblum, Marc K., primary, Hughes, Debbie, primary, Proszek, Paula Z., primary, Macdonald, Tobey J., primary, Preusser, Matthias, primary, Haberler, Christine, primary, Slavc, Irene, primary, Packer, Roger, primary, Ng, Ho-Keung, primary, Caspi, Shani, primary, Popović, Mara, primary, Faganel Kotnik, Barbara, primary, Wood, Matthew D., primary, Baird, Lissa, primary, Davare, Monika Ashok, primary, Solomon, David A., primary, Olsen, Thale Kristin, primary, Brandal, Petter, primary, Farrell, Michael, primary, Cryan, Jane B., primary, Capra, Michael, primary, Karremann, Michael, primary, Schittenhelm, Jens, primary, Schuhmann, Martin U., primary, Ebinger, Martin, primary, Dinjens, Winand N.M., primary, Kerl, Kornelius, primary, Hettmer, Simone, primary, Pietsch, Torsten, primary, Andreiuolo, Felipe, primary, Driever, Pablo Hernáiz, primary, Korshunov, Andrey, primary, Hiddingh, Lotte, primary, Worst, Barbara C., primary, Sturm, Dominik, primary, Zuckermann, Marc, primary, Witt, Olaf, primary, Bloom, Tabitha, primary, Mitchell, Clare, primary, Miele, Evelina, primary, Colafati, Giovanna Stefania, primary, Diomedi-Camassei, Francesca, primary, Bailey, Simon, primary, Moore, Andrew S., primary, Hassall, Timothy E.G., primary, Lowis, Stephen P., primary, Tsoli, Maria, primary, Cowley, Mark J., primary, Ziegler, David S., primary, Karajannis, Matthias A., primary, Aquilina, Kristian, primary, Hargrave, Darren R., primary, Carceller, Fernando, primary, Marshall, Lynley V., primary, von Deimling, Andreas, primary, Kramm, Christof M., primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Baker, Suzanne J., primary, Mastronuzzi, Angela, primary, Carai, Andrea, primary, Vinci, Maria, primary, Capper, David, primary, Popov, Sergey, primary, Ellison, David W., primary, Jacques, Thomas S., primary, Jones, David T.W., primary, and Jones, Chris, primary

Published
2023
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111. Data from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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112. Supplementary Data from Cross-Species Genomics Reveals Oncogenic Dependencies in ZFTA/C11orf95 Fusion–Positive Supratentorial Ependymomas

Author

Zheng, Tuyu, primary, Ghasemi, David R., primary, Okonechnikov, Konstantin, primary, Korshunov, Andrey, primary, Sill, Martin, primary, Maass, Kendra K., primary, Benites Goncalves da Silva, Patricia, primary, Ryzhova, Marina, primary, Gojo, Johannes, primary, Stichel, Damian, primary, Arabzade, Amir, primary, Kupp, Robert, primary, Benzel, Julia, primary, Taya, Shinichiro, primary, Adachi, Toma, primary, Shiraishi, Ryo, primary, Gerber, Nicolas U., primary, Sturm, Dominik, primary, Ecker, Jonas, primary, Sievers, Philipp, primary, Selt, Florian, primary, Chapman, Rebecca, primary, Haberler, Christine, primary, Figarella-Branger, Dominique, primary, Reifenberger, Guido, primary, Fleischhack, Gudrun, primary, Rutkowski, Stefan, primary, Donson, Andrew M., primary, Ramaswamy, Vijay, primary, Capper, David, primary, Ellison, David W., primary, Herold-Mende, Christel C., primary, Schüller, Ulrich, primary, Brandner, Sebastian, primary, Driever, Pablo Hernáiz, primary, Kros, Johan M., primary, Snuderl, Matija, primary, Milde, Till, primary, Grundy, Richard G., primary, Hoshino, Mikio, primary, Mack, Stephen C., primary, Gilbertson, Richard J., primary, Jones, David T.W., primary, Kool, Marcel, primary, von Deimling, Andreas, primary, Pfister, Stefan M., primary, Sahm, Felix, primary, Kawauchi, Daisuke, primary, and Pajtler, Kristian W., primary

Published
2023
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113. Supplementary Figure from The Pediatric Precision Oncology INFORM Registry: Clinical Outcome and Benefit for Patients with Very High-Evidence Targets

Author

van Tilburg, Cornelis M., primary, Pfaff, Elke, primary, Pajtler, Kristian W., primary, Langenberg, Karin P.S., primary, Fiesel, Petra, primary, Jones, Barbara C., primary, Balasubramanian, Gnana Prakash, primary, Stark, Sebastian, primary, Johann, Pascal D., primary, Blattner-Johnson, Mirjam, primary, Schramm, Kathrin, primary, Dikow, Nicola, primary, Hirsch, Steffen, primary, Sutter, Christian, primary, Grund, Kerstin, primary, von Stackelberg, Arend, primary, Kulozik, Andreas E., primary, Lissat, Andrej, primary, Borkhardt, Arndt, primary, Meisel, Roland, primary, Reinhardt, Dirk, primary, Klusmann, Jan-Henning, primary, Fleischhack, Gudrun, primary, Tippelt, Stephan, primary, von Schweinitz, Dietrich, primary, Schmid, Irene, primary, Kramm, Christof M., primary, von Bueren, André O., primary, Calaminus, Gabriele, primary, Vorwerk, Peter, primary, Graf, Norbert, primary, Westermann, Frank, primary, Fischer, Matthias, primary, Eggert, Angelika, primary, Burkhardt, Birgit, primary, Wößmann, Wilhelm, primary, Nathrath, Michaela, primary, Hecker-Nolting, Stefanie, primary, Frühwald, Michael C., primary, Schneider, Dominik T., primary, Brecht, Ines B., primary, Ketteler, Petra, primary, Fulda, Simone, primary, Koscielniak, Ewa, primary, Meister, Michael T., primary, Scheer, Monika, primary, Hettmer, Simone, primary, Schwab, Matthias, primary, Tremmel, Roman, primary, Øra, Ingrid, primary, Hutter, Caroline, primary, Gerber, Nicolas U., primary, Lohi, Olli, primary, Kazanowska, Bernarda, primary, Kattamis, Antonis, primary, Filippidou, Maria, primary, Goemans, Bianca, primary, Zwaan, C. Michel, primary, Milde, Till, primary, Jäger, Natalie, primary, Wolf, Stephan, primary, Reuss, David, primary, Sahm, Felix, primary, von Deimling, Andreas, primary, Dirksen, Uta, primary, Freitag, Angelika, primary, Witt, Ruth, primary, Lichter, Peter, primary, Kopp-Schneider, Annette, primary, Jones, David T.W., primary, Molenaar, Jan J., primary, Capper, David, primary, Pfister, Stefan M., primary, and Witt, Olaf, primary

Published
2023
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114. Supplementary Table 1 from Targeting the BRAF V600E Mutation in Multiple Myeloma

Author

Andrulis, Mindaugas, primary, Lehners, Nicola, primary, Capper, David, primary, Penzel, Roland, primary, Heining, Christoph, primary, Huellein, Jennifer, primary, Zenz, Thorsten, primary, von Deimling, Andreas, primary, Schirmacher, Peter, primary, Ho, Anthony D., primary, Goldschmidt, Hartmut, primary, Neben, Kai, primary, and Raab, Marc S., primary

Published
2023
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115. Table S4 from The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

Author

Buhl, Juliane L., primary, Selt, Florian, primary, Hielscher, Thomas, primary, Guiho, Romain, primary, Ecker, Jonas, primary, Sahm, Felix, primary, Ridinger, Johannes, primary, Riehl, Dennis, primary, Usta, Diren, primary, Ismer, Britta, primary, Sommerkamp, Alexander C., primary, Martinez-Barbera, J.P., primary, Wefers, Annika K., primary, Remke, Marc, primary, Picard, Daniel, primary, Pusch, Stefan, primary, Gronych, Jan, primary, Oehme, Ina, primary, van Tilburg, Cornelis M., primary, Kool, Marcel, primary, Kuhn, Daniela, primary, Capper, David, primary, von Deimling, Andreas, primary, Schuhmann, Martin U., primary, Herold-Mende, Christel, primary, Korshunov, Andrey, primary, Brummer, Tilman, primary, Pfister, Stefan M., primary, Jones, David T.W., primary, Witt, Olaf, primary, and Milde, Till, primary

Published
2023
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116. Supplemental Table Legend from The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

Author

Buhl, Juliane L., primary, Selt, Florian, primary, Hielscher, Thomas, primary, Guiho, Romain, primary, Ecker, Jonas, primary, Sahm, Felix, primary, Ridinger, Johannes, primary, Riehl, Dennis, primary, Usta, Diren, primary, Ismer, Britta, primary, Sommerkamp, Alexander C., primary, Martinez-Barbera, J.P., primary, Wefers, Annika K., primary, Remke, Marc, primary, Picard, Daniel, primary, Pusch, Stefan, primary, Gronych, Jan, primary, Oehme, Ina, primary, van Tilburg, Cornelis M., primary, Kool, Marcel, primary, Kuhn, Daniela, primary, Capper, David, primary, von Deimling, Andreas, primary, Schuhmann, Martin U., primary, Herold-Mende, Christel, primary, Korshunov, Andrey, primary, Brummer, Tilman, primary, Pfister, Stefan M., primary, Jones, David T.W., primary, Witt, Olaf, primary, and Milde, Till, primary

Published
2023
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117. Figure S1, Figure S2, Figure S3, Figure S4 from The Senescence-associated Secretory Phenotype Mediates Oncogene-induced Senescence in Pediatric Pilocytic Astrocytoma

Author

Buhl, Juliane L., primary, Selt, Florian, primary, Hielscher, Thomas, primary, Guiho, Romain, primary, Ecker, Jonas, primary, Sahm, Felix, primary, Ridinger, Johannes, primary, Riehl, Dennis, primary, Usta, Diren, primary, Ismer, Britta, primary, Sommerkamp, Alexander C., primary, Martinez-Barbera, J.P., primary, Wefers, Annika K., primary, Remke, Marc, primary, Picard, Daniel, primary, Pusch, Stefan, primary, Gronych, Jan, primary, Oehme, Ina, primary, van Tilburg, Cornelis M., primary, Kool, Marcel, primary, Kuhn, Daniela, primary, Capper, David, primary, von Deimling, Andreas, primary, Schuhmann, Martin U., primary, Herold-Mende, Christel, primary, Korshunov, Andrey, primary, Brummer, Tilman, primary, Pfister, Stefan M., primary, Jones, David T.W., primary, Witt, Olaf, primary, and Milde, Till, primary

Published
2023
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118. Supplementary Table 1, Figures 1 - 3 from Development, Characterization, and Reversal of Acquired Resistance to the MEK1 Inhibitor Selumetinib (AZD6244) in an In Vivo Model of Childhood Astrocytoma

Author

Bid, Hemant K., primary, Kibler, Aaron, primary, Phelps, Doris A., primary, Manap, Sagymbek, primary, Xiao, Linlin, primary, Lin, Jiayuh, primary, Capper, David, primary, Oswald, Duane, primary, Geier, Brian, primary, DeWire, Mariko, primary, Smith, Paul D., primary, Kurmasheva, Raushan T., primary, Mo, Xiaokui, primary, Fernandez, Soledad, primary, and Houghton, Peter J., primary

Published
2023
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119. Adult intracranial ependymoma - relevance of DNA methylation profiling for diagnosis, prognosis and treatment

Author

Träger, Malte, primary, Schweizer, Leonille, additional, Eilís, Pérez, additional, Schmid, Simone, additional, Hain, Elisabeth G, additional, Dittmayer, Carsten, additional, Onken, Julia, additional, Fukuoka, Kohei, additional, Ichimura, Koichi, additional, Schüller, Ulrich, additional, Dührsen, Lasse, additional, Müther, Michael, additional, Paulus, Werner, additional, Thomas, Christian, additional, Gutt-Will, Marielena, additional, Schucht, Philippe, additional, Maragkou, Theoni, additional, Schittenhelm, Jens, additional, Eckert, Franziska, additional, Niyazi, Maximilian, additional, Fleischmann, Daniel, additional, Dorostkar, Mario, additional, Feyer, Petra, additional, May, Sven-Axel, additional, Moskopp, Dag, additional, Badakhshi, Harun, additional, Radke, Cornelia, additional, Walter, Jan, additional, Ehret, Felix, additional, Capper, David, additional, and Kaul, David, additional

Published
2023
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121. Epigenetic neural glioblastoma enhances synaptic integration and predicts therapeutic vulnerability

Author

Drexler, Richard, Khatri, Robin, Sauvigny, Thomas, Mohme, Malte Eberhard, Maire, Cecile, Ryba, Alice, Zghaibeh, Yahya, Duhrsen, Lasse, Salviano-Silva, Amanda, Lamszus, Katrin, Westphal, Manfred, Gempt, Jens, Wefers, Annika K., Neumann, Julia, Bode, Helena, Hausmann, Fabian, Huber, Tobias, Bonn, Stefan, Jütten, Kerstin Maria, Delev, Daniel I., Weber, Katharina J., Harter, Patrick Nikolaus, Onken, Julia Sophie, Vajkoczy, Peter, Capper, David, Wiestler, Benedikt, Weller, Michael, Snijder, Berend, Buck, Alicia, Weiss, Tobias, Keough, Michael B., Ni, Lijun, Monje, Michelle, Silverbush, Dana, Hovestadt, Volker, Suva, Mario L., Krishna, Saritha, Hervey-Jumper, Shawn, Schüller, Ulrich, Heiland, Henrik Dieter, Hänzelmann, Sonja, Ricklefs, Franz Lennard, Drexler, Richard, Khatri, Robin, Sauvigny, Thomas, Mohme, Malte Eberhard, Maire, Cecile, Ryba, Alice, Zghaibeh, Yahya, Duhrsen, Lasse, Salviano-Silva, Amanda, Lamszus, Katrin, Westphal, Manfred, Gempt, Jens, Wefers, Annika K., Neumann, Julia, Bode, Helena, Hausmann, Fabian, Huber, Tobias, Bonn, Stefan, Jütten, Kerstin Maria, Delev, Daniel I., Weber, Katharina J., Harter, Patrick Nikolaus, Onken, Julia Sophie, Vajkoczy, Peter, Capper, David, Wiestler, Benedikt, Weller, Michael, Snijder, Berend, Buck, Alicia, Weiss, Tobias, Keough, Michael B., Ni, Lijun, Monje, Michelle, Silverbush, Dana, Hovestadt, Volker, Suva, Mario L., Krishna, Saritha, Hervey-Jumper, Shawn, Schüller, Ulrich, Heiland, Henrik Dieter, Hänzelmann, Sonja, and Ricklefs, Franz Lennard

Abstract

Neural-tumor interactions drive glioma growth as evidenced in preclinical models, but clinical validation is nascent. We present an epigenetically defined neural signature of glioblastoma that independently affects patients survival. We use reference signatures of neural cells to deconvolve tumor DNA and classify samples into low- or high-neural tumors. High-neural glioblastomas exhibit hypomethylated CpG sites and upregulation of genes associated with synaptic integration. Single-cell transcriptomic analysis reveals high abundance of stem cell-like malignant cells classified as oligodendrocyte precursor and neural precursor cell-like in high-neural glioblastoma. High-neural glioblastoma cells engender neuron-to-glioma synapse formation in vitro and in vivo and show an unfavorable survival after xenografting. In patients, a high-neural signature associates with decreased survival as well as increased functional connectivity and can be detected via DNA analytes and brain-derived neurotrophic factor in plasma. Our study presents an epigenetically defined malignant neural signature in high-grade gliomas that is prognostically relevant.

Published
2023

122. Diffuse hemispheric glioma, H3 G34-mutant

Author

WHO Classification of Tumours Editorial Board, WHO Classification of Tumours Editorial Board, ( ), Korshunov, A, Capper, David; https://orcid.org/0000-0003-1945-497X, Jones, David T W; https://orcid.org/0000-0002-2036-5141, Leske, Henning; https://orcid.org/0000-0002-3057-8730, Orr, Brent A; https://orcid.org/0000-0003-0997-4728, Rodriguez, Fausto J, Solomon, David A, Sturm, Dominik; https://orcid.org/0000-0003-0250-1696, Warren, Katherine E; https://orcid.org/0000-0003-2173-4129, Weller, Michael; https://orcid.org/0000-0002-1748-174X, WHO Classification of Tumours Editorial Board, WHO Classification of Tumours Editorial Board, ( ), Korshunov, A, Capper, David; https://orcid.org/0000-0003-1945-497X, Jones, David T W; https://orcid.org/0000-0002-2036-5141, Leske, Henning; https://orcid.org/0000-0002-3057-8730, Orr, Brent A; https://orcid.org/0000-0003-0997-4728, Rodriguez, Fausto J, Solomon, David A, Sturm, Dominik; https://orcid.org/0000-0003-0250-1696, Warren, Katherine E; https://orcid.org/0000-0003-2173-4129, and Weller, Michael; https://orcid.org/0000-0002-1748-174X

Published
2023

123. Molecular diagnostic tools for the World Health Organization (WHO) 2021 classification of gliomas, glioneuronal and neuronal tumors; an EANO guideline

Author

Sahm, Felix, Brandner, Sebastian, Bertero, Luca, Capper, David, French, Pim J., Figarella-Branger, Dominique, Giangaspero, Felice, Haberler, Christine, Hegi, Monika E., Kristensen, Bjarne W., Kurian, Kathreena M., Preusser, Matthias, Tops, Bastiaan B.J., van den Bent, Martin, Wick, Wolfgang, Reifenberger, Guido, Wesseling, Pieter, Sahm, Felix, Brandner, Sebastian, Bertero, Luca, Capper, David, French, Pim J., Figarella-Branger, Dominique, Giangaspero, Felice, Haberler, Christine, Hegi, Monika E., Kristensen, Bjarne W., Kurian, Kathreena M., Preusser, Matthias, Tops, Bastiaan B.J., van den Bent, Martin, Wick, Wolfgang, Reifenberger, Guido, and Wesseling, Pieter

Abstract

In the 5th edition of the WHO CNS tumor classification (CNS5, 2021), multiple molecular characteristics became essential diagnostic criteria for many additional CNS tumor types. For those tumors, an integrated, "histomolecular" diagnosis is required. A variety of approaches exists for determining the status of the underlying molecular markers. The present guideline focuses on the methods that can be used for assessment of the currently most informative diagnostic and prognostic molecular markers for the diagnosis of gliomas, glioneuronal and neuronal tumors. The main characteristics of the molecular methods are systematically discussed, followed by recommendations and information on available evidence levels for diagnostic measures. The recommendations cover DNA and RNA next-generation-sequencing, methylome profiling, and select assays for single/limited target analyses, including immunohistochemistry. Additionally, because of its importance as a predictive marker in IDH-wildtype glioblastomas, tools for the analysis of MGMT promoter methylation status are covered. A structured overview of the different assays with their characteristics, especially their advantages and limitations, is provided, and requirements for input material and reporting of results are clarified. General aspects of molecular diagnostic testing regarding clinical relevance, accessibility, cost, implementation, regulatory, and ethical aspects are discussed as well. Finally, we provide an outlook on new developments in the landscape of molecular testing technologies in neuro-oncology.

Published
2023

124. Original Research Molecular diagnostics enables detection of actionable targets: the Pediatric Targeted Therapy 2.0 registry

Author

Ecker, Jonas, Selt, Florian, Sturm, Dominik, Sill, Martin, Korshunov, Andrey, Hirsch, Steffen, Capper, David, Dikow, Nicola, Sutter, Christian, Mueller, Carina, Sigaud, Romain, Eggert, Angelika, Simon, Thorsten, Niehues, Tim, von Deimling, Andreas, Pajtler, Kristian W., van Tilburg, Cornelis M., Jones, David T. W., Sahm, Felix, Pfister, Stefan M., Witt, Olaf, Milde, Till, Ecker, Jonas, Selt, Florian, Sturm, Dominik, Sill, Martin, Korshunov, Andrey, Hirsch, Steffen, Capper, David, Dikow, Nicola, Sutter, Christian, Mueller, Carina, Sigaud, Romain, Eggert, Angelika, Simon, Thorsten, Niehues, Tim, von Deimling, Andreas, Pajtler, Kristian W., van Tilburg, Cornelis M., Jones, David T. W., Sahm, Felix, Pfister, Stefan M., Witt, Olaf, and Milde, Till

Abstract

Background: Precision oncology requires diagnostic accuracy and robust detection of actionable alterations. The Pediatric Targeted Therapy (PTT) 2.0 program aims at improving diagnostic accuracy by addition of molecular analyses to the existing histological diagnosis and detection of actionable alterations for relapsed paediatric oncology patients, in cases with limited availability of tumour material.Methods: Paediatric patients diagnosed with relapse or progression of a central nervous system tumour (n = 178), a sarcoma (n = 41) or another solid tumour (n = 44) were included. DNA methylation array, targeted gene panel sequencing on tumour and blood (130 genes), RNA sequencing in selected cases and a pathway-specific immunohistochemistry (IHC) panel were performed using limited formalin-fixed paraffin embedded tissue from any disease episode available. The clinical impact of reported findings was assessed by a serial questionnaire-based follow-up.Results: Integrated molecular diagnostics resulted in refined or changed diagnosis in 117/263 (44%) tumours. Actionable targets were detected in 155/263 (59%) cases. Constitutional DNA variants with clinical relevance were identified in 16/240 (7%) of patients, half of which were previously unknown. Clinical follow-up showed that 26/263 (10%) of patients received mechanism-of-action based treatment matched to the molecular findings.Conclusion: Next-generation diagnostics adds robust and relevant information on diagnosis, actionable alterations and cancer predisposition syndromes even when tissue from the current disease episode is limited. 2022 Elsevier Ltd. All rights reserved.

Published
2023

125. EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection

Author

Capper, David; https://orcid.org/0000-0003-1945-497X, Reifenberger, Guido, French, Pim J, Schweizer, Leonille; https://orcid.org/0000-0002-4649-2587, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Touat, Mehdi, Niclou, Simone P; https://orcid.org/0000-0002-3417-9534, Euskirchen, Philipp; https://orcid.org/0000-0002-9138-805X, Haberler, Christine; https://orcid.org/0000-0003-1016-0545, Hegi, Monika E, Brandner, Sebastian; https://orcid.org/0000-0002-9821-0342, Le Rhun, Émilie; https://orcid.org/0000-0002-9408-3278, Rudà, Roberta, Sanson, Marc, Tabatabai, Ghazaleh; https://orcid.org/0000-0002-3542-8782, Sahm, Felix; https://orcid.org/0000-0001-5441-1962, Wen, Patrick Y, Wesseling, Pieter, Preusser, Matthias; https://orcid.org/0000-0003-3541-2315, van den Bent, Martin J; https://orcid.org/0000-0001-5710-5127, Capper, David; https://orcid.org/0000-0003-1945-497X, Reifenberger, Guido, French, Pim J, Schweizer, Leonille; https://orcid.org/0000-0002-4649-2587, Weller, Michael; https://orcid.org/0000-0002-1748-174X, Touat, Mehdi, Niclou, Simone P; https://orcid.org/0000-0002-3417-9534, Euskirchen, Philipp; https://orcid.org/0000-0002-9138-805X, Haberler, Christine; https://orcid.org/0000-0003-1016-0545, Hegi, Monika E, Brandner, Sebastian; https://orcid.org/0000-0002-9821-0342, Le Rhun, Émilie; https://orcid.org/0000-0002-9408-3278, Rudà, Roberta, Sanson, Marc, Tabatabai, Ghazaleh; https://orcid.org/0000-0002-3542-8782, Sahm, Felix; https://orcid.org/0000-0001-5441-1962, Wen, Patrick Y, Wesseling, Pieter, Preusser, Matthias; https://orcid.org/0000-0003-3541-2315, and van den Bent, Martin J; https://orcid.org/0000-0001-5710-5127

Abstract

The mainstay of treatment for adult patients with gliomas, glioneuronal and neuronal tumors consists of combinations of surgery, radiotherapy, and chemotherapy. For many systemic cancers, targeted treatments are a part of the standard of care, however, the predictive significance of most of these targets in central nervous system (CNS) tumors remains less well-studied. Despite that, there is increasing use of advanced molecular diagnostics that identify potential targets, and tumor-agnostic regulatory approvals on targets also present in CNS tumors have been granted. This raises the question of when and for which targets it is meaningful to test in adult patients with CNS tumors. This evidence-based guideline reviews the evidence available for targeted treatment for alterations in the RAS/MAPK pathway (BRAF, NF1), in growth factor receptors (EGFR, ALK, fibroblast growth factor receptor (FGFR), neurotrophic tyrosine receptor kinase (NTRK), platelet-derived growth factor receptor alpha, and ROS1), in cell cycle signaling (CDK4/6, MDM2/4, and TSC1/2) and altered genomic stability (mismatch repair, POLE, high tumor mutational burden (TMB), homologous recombination deficiency) in adult patients with gliomas, glioneuronal and neuronal tumors. At present, targeted treatment for BRAF p.V600E alterations is to be considered part of the standard of care for patients with recurrent gliomas, pending regulatory approval. For approved tumor agnostic treatments for NTRK fusions and high TMB, the evidence for efficacy in adult patients with CNS tumors is very limited, and treatment should preferably be given within prospective clinical registries and trials. For targeted treatment of CNS tumors with FGFR fusions or mutations, clinical trials are ongoing to confirm modest activity so far observed in basket trials. For all other reviewed targets, evidence of benefit in CNS tumors is currently lacking, and testing/treatment should be in the context of available clinical trials.

Published
2023

126. Next-generation personalised medicine for high-risk paediatric cancer patients – The INFORM pilot study

Author

Worst, Barbara C., van Tilburg, Cornelis M., Balasubramanian, Gnana Prakash, Fiesel, Petra, Witt, Ruth, Freitag, Angelika, Boudalil, Miream, Previti, Christopher, Wolf, Stephan, Schmidt, Sabine, Chotewutmontri, Sasithorn, Bewerunge-Hudler, Melanie, Schick, Matthias, Schlesner, Matthias, Hutter, Barbara, Taylor, Lenka, Borst, Tobias, Sutter, Christian, Bartram, Claus R., Milde, Till, Pfaff, Elke, Kulozik, Andreas E., von Stackelberg, Arend, Meisel, Roland, Borkhardt, Arndt, Reinhardt, Dirk, Klusmann, Jan-Henning, Fleischhack, Gudrun, Tippelt, Stephan, Dirksen, Uta, Jürgens, Heribert, Kramm, Christof M., von Bueren, Andre O., Westermann, Frank, Fischer, Matthias, Burkhardt, Birgit, Wößmann, Wilhelm, Nathrath, Michaela, Bielack, Stefan S., Frühwald, Michael C., Fulda, Simone, Klingebiel, Thomas, Koscielniak, Ewa, Schwab, Matthias, Tremmel, Roman, Driever, Pablo Hernáiz, Schulte, Johannes H., Brors, Benedikt, von Deimling, Andreas, Lichter, Peter, Eggert, Angelika, Capper, David, Pfister, Stefan M., Jones, David T.W., and Witt, Olaf

Published
2016
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128. Tumors diagnosed as cerebellar glioblastoma comprise distinct molecular entities

Author

Reinhardt, Annekathrin, Stichel, Damian, Schrimpf, Daniel, Koelsche, Christian, Wefers, Annika K., Ebrahimi, Azadeh, Sievers, Philipp, Huang, Kristin, Casalini, M. Belén, Fernández-Klett, Francisco, Suwala, Abigail, Weller, Michael, Gramatzki, Dorothee, Felsberg, Joerg, Reifenberger, Guido, Becker, Albert, Hans, Volkmar H., Prinz, Marco, Staszewski, Ori, Acker, Till, Dohmen, Hildegard, Hartmann, Christian, Paulus, Werner, Heß, Katharina, Brokinkel, Benjamin, Schittenhelm, Jens, Buslei, Rolf, Deckert, Martina, Mawrin, Christian, Hewer, Ekkehard, Pohl, Ute, Jaunmuktane, Zane, Brandner, Sebastian, Unterberg, Andreas, Hänggi, Daniel, Platten, Michael, Pfister, Stefan M., Wick, Wolfgang, Herold-Mende, Christel, Korshunov, Andrey, Reuss, David E., Sahm, Felix, Jones, David T. W., Capper, David, and von Deimling, Andreas

Published
2019
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130. YAP1 subgroup supratentorial ependymoma requires TEAD and nuclear factor I-mediated transcriptional programmes for tumorigenesis

Author

Pajtler, Kristian W., Wei, Yiju, Okonechnikov, Konstantin, Silva, Patricia B. G., Vouri, Mikaella, Zhang, Lei, Brabetz, Sebastian, Sieber, Laura, Gulley, Melissa, Mauermann, Monika, Wedig, Tatjana, Mack, Norman, Imamura Kawasawa, Yuka, Sharma, Tanvi, Zuckermann, Marc, Andreiuolo, Felipe, Holland, Eric, Maass, Kendra, Körkel-Qu, Huiqin, Liu, Hai-Kun, Sahm, Felix, Capper, David, Bunt, Jens, Richards, Linda J., Jones, David T. W., Korshunov, Andrey, Chavez, Lukas, Lichter, Peter, Hoshino, Mikio, Pfister, Stefan M., Kool, Marcel, Li, Wei, and Kawauchi, Daisuke

Published
2019
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131. DNA methylation signature is prognostic of choroid plexus tumor aggressiveness

Author

Pienkowska, Malgorzata, Choufani, Sanaa, Turinsky, Andrei L., Guha, Tanya, Merino, Diana M., Novokmet, Ana, Brudno, Michael, Weksberg, Rosanna, Shlien, Adam, Hawkins, Cynthia, Bouffet, Eric, Tabori, Uri, Gilbertson, Richard J., Finlay, Jonathan L., Jabado, Nada, Thomas, Christian, Sill, Martin, Capper, David, Hasselblatt, Martin, and Malkin, David

Published
2019
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132. New therapeutic target for pediatric anaplastic ependymoma control: study of anti-tumor activity by a Kunitz-type molecule, Amblyomin-X

Author

Pavon, Lorena Favaro, Capper, David, Sibov, Tatiana Tais, de Toledo, Silvia Regina Caminada, Thomale, Ulrich-W., de Souza, Jean Gabriel, Cabral, Francisco Romero, Berra, Carolina Maria, Silva da Costa, Marcos Devanir, Mendonça Niçacio, Jardel, Dastoli, Patrícia Alessandra, de Oliveira, Daniela Mara, Malheiros, Suzana M. F., da Cruz, Edgar Ferreira, Malheiros, Jackeline Moraes, de Oliveira, Sérgio Mascarenhas, Silva, Nasjla Saba, Petrilli, Antonio Sérgio, Cappellano, Andrea Maria, Brunialti, Milena Colò, Salomão, Reinaldo, de Paiva Neto, Manoel A., Chudzinski-Tavassi, Ana Marisa, and Cavalheiro, Sérgio

Published
2019
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134. EANO guideline on rational molecular testing of gliomas, glioneuronal, and neuronal tumors in adults for targeted therapy selection

Author

Capper, David, primary, Reifenberger, Guido, additional, French, Pim J, additional, Schweizer, Leonille, additional, Weller, Michael, additional, Touat, Mehdi, additional, Niclou, Simone P, additional, Euskirchen, Philipp, additional, Haberler, Christine, additional, Hegi, Monika E, additional, Brandner, Sebastian, additional, Le Rhun, Emilie, additional, Rudà, Roberta, additional, Sanson, Marc, additional, Tabatabai, Ghazaleh, additional, Sahm, Felix, additional, Wen, Patrick Y, additional, Wesseling, Pieter, additional, Preusser, Matthias, additional, and van den Bent, Martin J, additional

Published
2023
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137. Methylation differences in Alzheimer’s disease neuropathologic change in the aged human brain

Author

Lang, Anna-Lena, primary, Eulalio, Tiffany, additional, Fox, Eddie, additional, Yakabi, Koya, additional, Bukhari, Syed A., additional, Kawas, Claudia H., additional, Corrada, Maria M., additional, Montgomery, Stephen B., additional, Heppner, Frank L., additional, Capper, David, additional, Nachun, Daniel, additional, and Montine, Thomas J., additional

Published
2022
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138. Robust methylation‐based classification of brain tumours using nanopore sequencing

Author

Kuschel, Luis P., primary, Hench, Jürgen, additional, Frank, Stephan, additional, Hench, Ivana Bratic, additional, Girard, Elodie, additional, Blanluet, Maud, additional, Masliah‐Planchon, Julien, additional, Misch, Martin, additional, Onken, Julia, additional, Czabanka, Marcus, additional, Yuan, Dongsheng, additional, Lukassen, Sören, additional, Karau, Philipp, additional, Ishaque, Naveed, additional, Hain, Elisabeth G., additional, Heppner, Frank, additional, Idbaih, Ahmed, additional, Behr, Nikolaus, additional, Harms, Christoph, additional, Capper, David, additional, and Euskirchen, Philipp, additional

Published
2022
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139. BIOM-32. DNA METHYLATION SUBCLASSES PREDICT THE BENEFIT FROM GROSS TOTAL TUMOR RESECTION IN IDH-WILDTYPE GLIOBLASTOMA PATIENTS

Author

Drexler, Richard, primary, Schüller, Ulrich, additional, Eckhardt, Alicia, additional, Filipski, Katharina, additional, Hartung, Tabea, additional, Harter, Patrick, additional, Divé, Iris, additional, Forster, Marie-therese, additional, Czabanka, Marcus, additional, Jelgersma, Claudius, additional, Onken, Julia, additional, Vajkoczy, Peter, additional, Capper, David, additional, Siewert, Christin, additional, Sauvigny, Thomas, additional, Lamszus, Katrin, additional, Westphal, Manfred, additional, Dührsen, Lasse, additional, and Ricklefs, Franz, additional

Published
2022
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140. H3-/IDH-wild type pediatric glioblastoma is comprised of molecularly and prognostically distinct subtypes with associated oncogenic drivers

Author

Korshunov, Andrey, Schrimpf, Daniel, Ryzhova, Marina, Sturm, Dominik, Chavez, Lukas, Hovestadt, Volker, Sharma, Tanvi, Habel, Antje, Burford, Anna, Jones, Chris, Zheludkova, Olga, Kumirova, Ella, Kramm, Christof M., Golanov, Andrey, Capper, David, von Deimling, Andreas, Pfister, Stefan M., and Jones, David T. W.

Published
2017
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141. Pan-mutant IDH1 inhibitor BAY 1436032 for effective treatment of IDH1 mutant astrocytoma in vivo

Author

Pusch, Stefan, Krausert, Sonja, Fischer, Viktoria, Balss, Jörg, Ott, Martina, Schrimpf, Daniel, Capper, David, Sahm, Felix, Eisel, Jessica, Beck, Ann-Christin, Jugold, Manfred, Eichwald, Viktoria, Kaulfuss, Stefan, Panknin, Olaf, Rehwinkel, Hartmut, Zimmermann, Katja, Hillig, Roman C., Guenther, Judith, Toschi, Luisella, Neuhaus, Roland, Haegebart, Andrea, Hess-Stumpp, Holger, Bauser, Markus, Wick, Wolfgang, Unterberg, Andreas, Herold-Mende, Christel, Platten, Michael, and von Deimling, Andreas

Published
2017
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142. Polymorphous low-grade neuroepithelial tumor of the young (PLNTY): an epileptogenic neoplasm with oligodendroglioma-like components, aberrant CD34 expression, and genetic alterations involving the MAP kinase pathway

Author

Huse, Jason T., Snuderl, Matija, Jones, David T. W., Brathwaite, Carole D., Altman, Nolan, Lavi, Ehud, Saffery, Richard, Sexton-Oates, Alexandra, Blumcke, Ingmar, Capper, David, Karajannis, Matthias A., Benayed, Ryma, Chavez, Lukas, Thomas, Cheddhi, Serrano, Jonathan, Borsu, Laetitia, Ladanyi, Marc, and Rosenblum, Marc K.

Published
2017
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148. Expanded analysis of high-grade astrocytoma with piloid features identifies an epigenetically and clinically distinct subtype associated with neurofibromatosis type 1

Author

Cimino, Patrick J., primary, Ketchum, Courtney, additional, Turakulov, Rust, additional, Singh, Omkar, additional, Abdullaev, Zied, additional, Giannini, Caterina, additional, Pytel, Peter, additional, Lopez, Giselle Yvette, additional, Colman, Howard, additional, Nasrallah, MacLean P., additional, Santi, Mariarita, additional, Fernandes, Igor Lima, additional, Nirschl, Jeff, additional, Dahiya, Sonika, additional, Neill, Stewart, additional, Solomon, David, additional, Perez, Eilis, additional, Capper, David, additional, Mani, Haresh, additional, Caccamo, Dario, additional, Ball, Matthew, additional, Badruddoja, Michael, additional, Chkheidze, Rati, additional, Camelo-Piragua, Sandra, additional, Fullmer, Joseph, additional, Alexandrescu, Sanda, additional, Yeaney, Gabrielle, additional, Eberhart, Charles, additional, Martinez-Lage, Maria, additional, Chen, Jie, additional, Zach, Leor, additional, Kleinschmidt-DeMasters, B. K., additional, Hefti, Marco, additional, Lopes, Maria-Beatriz, additional, Nuechterlein, Nicholas, additional, Horbinski, Craig, additional, Rodriguez, Fausto J., additional, Quezado, Martha, additional, Pratt, Drew, additional, and Aldape, Kenneth, additional

Published
2022
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149. Molecular and clinicopathologic characteristics of gliomas with EP300::BCOR fusions

Author

Wu, Zhichao, primary, Rajan, Sharika, additional, Chung, Hye-Jung, additional, Raffeld, Mark, additional, Panneer Selvam, Pavalan, additional, Schweizer, Leonille, additional, Perry, Arie, additional, Samuel, David, additional, Giannini, Caterina, additional, Ragunathan, Aditya, additional, Frosch, Matthew P., additional, Marshall, Michael S., additional, Boué, Daniel R., additional, Donev, Kliment, additional, Neill, Stewart G., additional, Fernandes, Igor, additional, Resnick, Adam, additional, Rood, Brian, additional, Cummings, Thomas J., additional, Buckley, Anne F., additional, Szymanski, Linda, additional, Neto, Osorio Lopes Abath, additional, Zach, Leor, additional, Colman, Howard, additional, Cheshier, Samuel, additional, Ziskin, Jennifer, additional, Tyagi, Manoj, additional, Capper, David, additional, Abdullaev, Zied, additional, Cimino, Patrick J., additional, Quezado, Martha, additional, Pratt, Drew, additional, and Aldape, Kenneth, additional

Published
2022
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150. Anaplastic ganglioglioma—A diagnosis comprising several distinct tumour types

Author

Reinhardt, Annekathrin, primary, Pfister, Kristin, additional, Schrimpf, Daniel, additional, Stichel, Damian, additional, Sahm, Felix, additional, Reuss, David E., additional, Capper, David, additional, Wefers, Annika K., additional, Ebrahimi, Azadeh, additional, Sill, Martin, additional, Felsberg, Joerg, additional, Reifenberger, Guido, additional, Becker, Albert, additional, Prinz, Marco, additional, Staszewski, Ori, additional, Hartmann, Christian, additional, Schittenhelm, Jens, additional, Gramatzki, Dorothee, additional, Weller, Michael, additional, Olar, Adriana, additional, Rushing, Elisabeth Jane, additional, Bergmann, Markus, additional, Farrell, Michael A., additional, Blümcke, Ingmar, additional, Coras, Roland, additional, Beckervordersandforth, Jan, additional, Kim, Se Hoon, additional, Rogerio, Fabio, additional, Dimova, Petia S., additional, Niehusmann, Pitt, additional, Unterberg, Andreas, additional, Platten, Michael, additional, Pfister, Stefan M., additional, Wick, Wolfgang, additional, Herold‐Mende, Christel, additional, and von Deimling, Andreas, additional

Published
2022
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