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La investigación estimula el pensamiento crítico y la creatividad tanto en educadores como en educandos. Es a través de la investigación que se alienta la curiosidad necesaria para la formación de profesionales con habilidades y conocimientos nuevos, capaces de resolver, desde la innovación, ciencia y tecnología, los problemas ambientales y sociales que surgen de la demanda global de recursos en un mundo en acelerado desarrollo. Gracias a los procesos de formación de la investigación, se genera, en los estudiantes que participan de ello, un aprendizaje autónomo, crítico, epistemológico, que despierta su curiosidad por el campo de la investigación, descubriendo escenarios valiosos en el encuentro entre la realidad y el planteamiento de alternativas investigativas, presentándose como ambientes educativos flexibles, de lógicas colaborativas, donde los estudiantes se sumergen en la comprensión de temáticas, ideas, nociones, métodos y metodologías que permiten comprender y apropiar los procesos de reinventar realidades (Juajibioy et al., 2021).

Iron is an essential element for Escherichia, Salmonella and Shigella species. Acquisition of sufficient amounts of iron is difficult in many environments, including the intestinal tract, where these bacteria usually reside. Members of these genera have multiple iron transport systems to transport both ferrous and ferric iron. These include transporters for free ferrous iron, for ferric iron associated with chelators, and heme. The number and types of transport systems in any species reflects the diversity of niches it can inhabit. Many of the iron transport genes are found on mobile genetic elements or pathogenicity islands, and there is evidence of spread of the genes among different species and pathotypes. This is notable among the pathogenic members of the genera in which iron transport systems acquired by horizontal gene transfer allow the bacteria to overcome host innate defenses that act to restrict the availability of iron to the pathogen. The need for iron is balanced by the need to avoid iron overload, since excess iron is toxic for the cell. Genes for iron transport and metabolism are tightly regulated and respond to environmental cues including iron availability, oxygen and temperature. The master regulators, the iron sensor Fur and the Fur-regulated sRNA RyhB, coordinate expression of iron transport and cellular metabolism genes in response to the availability of iron.

Tití gris (Saguinus leucopus) es un primate endémico de Colombia, categorizado como vulnerable (VU) según la Unión Internacional para la Conservación de la Naturaleza (UICN). La especie posee hábitos omnívoros y se caracteriza por el consumo de frutos blandos e insectos. En esta nota, reportamos un evento de depredación de este primate sobre un polluelo de gallina americana o gallina kika, a partir de un registro fotográfico en el municipio de Victoria, Caldas, Colombia.

Production water represents a major sustainability challenge for oil and gas industries, which is why various strategies have emerged globally to encourage its reuse in proactive projects. One of the most recognized strategies has been developed in the Omani desert where artificial wetlands were designed to physically and biologically treat production water. The present study proposes to adapt this strategy to a Colombian context to further study the sustainability of production water reuse. The methodology of this study consists of three phases: evaluate in-field production water through the characterization of irrigation water, identify and prioritize the variables of said strategy, and propose an adequate soil irrigation strategy for a Colombian field. An expert matrix and multicriteria analysis are used to identify the level of interaction among the variables presented, according to the criteria of experts in the field of sustainable production water management. Water quality was ranked by the experts as the most important single variable. On a scale of 1–5, the variables with the highest level of interaction (2.8) are water quality and the type of treatment seedlings, and the variables with the lowest level of interaction (1.3) are additional water treatment systems and final water use. These results have led to the formation of a hierarchy of variables according to impact, which has been used to create a triple bottom line diagram and demonstrate the feasibility of implementing the Omani strategy in Colombia.

El objetivo de este informe es describir la evolución reciente de las líneas de crédito en moneda extranjera de los bancos colombianos y presentar los principales resultados de la última encuesta de endeudamiento externo y cupos, la cual fue aplicada por el Departamento de Estabilidad Financiera del Banco de la República a una muestra representativa de bancos comerciales que tienen líneas de crédito en moneda extranjera.

Este reporte presenta los resultados de la Encuesta trimestral sobre la situación del crédito en Colombia, en la que participan los intermediarios financieros que realizan operaciones de crédito, como bancos, compañías de financiamiento (CFC) y cooperativas financieras (cooperativas). El objetivo de este informe es analizar la percepción que tienen las entidades sobre la oferta, la demanda y el acceso al crédito, los cambios en las políticas de asignación en el corto plazo y las expectativas que tienen los intermediarios financieros para el próximo trimestre. Además de presentar el comportamiento de las modificaciones y reestructuraciones de los créditos. El presente documento está compuesto por cinco secciones. La primera analiza el panorama general de la situación del crédito, centrándose en las percepciones que tienen los EC con respecto a su demanda y oferta. La segunda se enfoca en la situación sectorial. En la tercera sección se analizan en detalle los cambios en las políticas de asignación de nuevos créditos. La cuarta presenta los principales resultados sobre modificaciones y reestructuración de préstamos. Finalmente, en la quinta sección se incluyen algunos comentarios generales que resumen la situación actual del crédito en Colombia.

Iron is an essential element for Vibrio cholerae to survive, and Feo, the major bacterial system for ferrous iron transport, is important for growth of this pathogen in low-oxygen environments. To gain insight into its biochemical mechanism, we evaluated the effects of widely used ATPase inhibitors on the ATP hydrolysis activity of the N-terminal domain of V. cholerae FeoB. Our results showed that sodium orthovanadate and sodium azide effectively inhibit the catalytic activity of the N-terminal domain of V. cholerae FeoB. Further, sodium orthovanadate was the more effective inhibitor against V. cholerae ferrous iron transport in vivo. These results contribute to a more comprehensive biochemical understanding of Feo function, and shed light on designing effective inhibitors against bacterial FeoB proteins.

Los estudios psicométricos permiten realizar mediciones basadas en correlaciones de vectores que producen predicciones de rasgos del comportamiento humano. Con la creciente digitalización, la psicometría ha sido usada para diseñar perfiles de los individuos a través de diversos mecanismos: big data, machine learning, etc. Lejos de ser neutrales, estos perfiles están basados en metodologías que producen sesgos que afectan a los individuos perfilados. Así, este artículo plantea que la psicometría elabora un perfil-dividuo que genera una reducción de los individuos y produce formas en las que estos tienen que comportarse. Para ello, se ejemplifica con un caso de medición psicométrica basada en el reconocimiento facial.

The growing degree-days (GDD) provide an estimate of the accumulated thermal energy available for the development of a crop. The use of GDD allows measuring the heat requirements associated with the phenological stages of the crop, which allows in turn, to predict when a certain plant stage will occur knowing the daily temperatures. The aim of this study was to establish relationships among the effect of degree days (DD) to vegetative growth, first flowering and fructification (VG, Fl and Fr), on total yield per plant (TY/P) of eggplant grown under open-field conditions employing a randomized complete block design with 15 genotypes and four replicates. The results showed that: 1) The genotypes that initiated fruit production in less time required fewer GDD (892.14-1,077.71 °C) for this phenological phase, obtaining higher productivity. 2) The genotypes C035 and C040 had an average yield higher than the national average with values of 83.75 and 84.86 t ha-1, being identified as future varieties to be produced in the Caribbean region. 3) The Caribbean region is suitable for the establishment of the crop as there were no events with limiting temperatures for this species (higher than 35 °C and lower than 15 °C). 4) The principal component analysis showed associations among the variable YT/P with the genotypes C011, C042, and C015; meanwhile, C032, C025, and C028 were associated with the variables DD to VG, Fl, and Fr. These results would be useful in developing a model to estimate yield with DD. RESUMEN Los grados días de desarrollo (GDD) proporcionan una estimación de la energía térmica acumulada disponible para el desarrollo de un cultivo. El uso de los GDD permite medir los requerimientos de calor asociados a las etapas fenológicas del cultivo, lo que a su vez permite predecir cuándo ocurrirá una determinada etapa de la planta conociendo las temperaturas diarias. Este estudio tuvo como objetivo determinar las relaciones entre el efecto de los grados días (GD) hasta el crecimiento vegetativo, la primera floración y fructificación (CV, Fl y Fr) sobre el rendimiento total por planta (RT/P) de berenjena cultivada en campo abierto bajo un diseño de bloques completos al azar con 15 genotipos y cuatro repeticiones. Los resultados mostraron que: 1) Los genotipos que inician producción de frutos en menor tiempo requieren menos grados días (892,14-1.077,71 °C) para esta fase fenológica, obteniendo una mayor producción. 2) Los genotipos C035 y C040 tuvieron un rendimiento promedio superior al promedio nacional con valores de 83,75 y 84,86 t ha-1, identificándose como futuras variedades a producir en la región del Caribe. 3) La región Caribe es apta para el establecimiento del cultivo, debido a que no hubo eventos limitantes de temperatura para la especie (temperaturas mayores a 35 °C y menores a 15 °C). 4) El análisis de componentes principales mostro asociación entre los genotipos C011, C042 y C015 con las variables RT/P, y los genotipos C011, C025 y C028 con los GD a CV, Fl y Fr. Estos resultados serían útiles para desarrollar un modelo para estimar el rendimiento con base en los GD.

We consider certain finite sets of circle-valued functions defined on intervals of real numbers and estimate how large the intervals must be for the values of these functions to be uniformly distributed in an approximate way. This is used to establish some general conditions under which a random construction introduced by Katznelson for the integers yields sets that are dense in the Bohr group. We obtain in this way very sparse sets of real numbers (and of integers) on which two different almost periodic functions cannot agree, what makes them amenable to be used in sampling theorems for these functions. These sets can be made as sparse as to have zero asymptotic density or as to be t-sets, i.e., to be sets that intersect any of their translates in a bounded set. Many of these results are proved not only for almost periodic functions but also for classes of functions generated by more general complex exponential functions, including chirps., Comment: 22 pages

Este reporte presenta los resultados de la Encuesta trimestral sobre la situación del crédito en Colombia, en la que participan los intermediarios financieros que realizan operaciones de crédito, como bancos, compañías de financiamiento (CFC) y cooperativas financieras (cooperativas). El objetivo de este informe es analizar la percepción que tienen las entidades sobre la oferta, la demanda y el acceso al crédito, los cambios en las políticas de asignación en el corto plazo y las expectativas que tienen los intermediarios financieros para el próximo trimestre. Además de presentar el comportamiento de las modificaciones y reestructuraciones de los créditos. El presente documento está compuesto por cinco secciones. La primera analiza el panorama general de la situación del crédito, centrándose en las percepciones que tienen los EC con respecto a su demanda y oferta. La segunda se enfoca en la situación sectorial. En la tercera sección se analizan en detalle los cambios en la oferta y las políticas de asignación de nuevos créditos. La cuarta presenta los principales resultados sobre modificaciones y reestructuración de préstamos. Finalmente, en la quinta sección se incluyen algunos comentarios generales que resumen la situación actual del crédito en Colombia.

The literature that explains the neurological mechanisms underlying the development or compensation of idiopathic scoliosis is limited. The objective of the article is to describe and integrate the mechanisms and nerve pathways through which idiopathic scoliosis is compensated and/or developed. A narrative systematic review in different databases of the studies published between January 1, 1967 and April 1, 2021 was performed, using the following terms: "scoliosis", "vision", "eye", "vestibule", "labyrinth" "posture", "balance", "eye movements", "cerebellum", "proprioception", and "physiological adaptation". In the search, 1112 references were identified, of which 50 were finally included: 46 observational analytical clinical studies-descriptive (between cohorts, report and series of cases) and 4 experimental studies. In the neurological response to idiopathic scoliosis, the sensory-cortical integration of the afferences in the visual-oculomotor-vestibular-proprioceptive systems, allows modifications at the postural level in order to achieve an initial compensation on the sagittal balance and the centre of body mass; however, over time these compensation mechanisms may be exhausted causing progression of the initial deformity.

Human and wildlife conflicts pose conservation challenges for several charismatic species worldwide. Given their close long-standing interactions with wildlife, indigenous communities set an interesting framework to identify factors establishing these relationships. The first step is to account the perceptions and symbolisms of indigenous communities to define and complement conservation efforts. We used multi-temporal and multi-criteria analyses to assess species habitat suitability of three large carnivores (jaguar, puma, and coyote), and quantified the overlap with the Mixtec and Zapotec indigenous territories in southern Mexico. We observed a positive and proactive relationship between indigenous communities’ self-identification and a high species habitat suitability for the conservation of these large carnivores in the Sierra Norte, Sierra Sur, Coastal, and Mixtec regions. Given that most of these areas occur outside natural protected areas, the inclusion of indigenous communities in the management and planning of their territory is crucial for preserving their ethnocentric vision and ensuring long-term conservation of these charismatic large carnivores and their habitat.

Monitorear el riesgo de crédito es fundamental para preservar la estabilidad del sistema financiero. Este informe presenta, para cada modalidad de cartera, un análisis de las condiciones de crédito y de los principales indicadores de riesgo.

Organizing pneumonia is a nonspecific pulmonary response pattern associated with a variety of clinical contexts including viral infections. The classic radiological manifestations are peribronchovascular/peripheral ground glass opacities or consolidations and may be accompanied by nodules, masses, and interstitial opacities. We describe the case of a 62-year-old male patient with SARS-CoV-2 pneumonia and torpid clinical and radiological evolution in whom organizing pneumonia was documented through transbronchial biopsy and imaging findings, with a good response to corticosteroids. The importance of recognizing the development of organizing pneumonia lies in the better prognosis and outcome in those patients who receive treatment with corticosteroids, however, the clinical and radiological suspicion must be confirmed with biopsy because radiological findings associated with bacterial coinfection may overlap.

En virtud del mandato otorgado por la Constitución Política de Colombia y de acuerdo con lo reglamentado por la Ley 31 de 1992, el Banco de la Repú-blica tiene la responsabilidad de velar por la estabilidad de los precios. El adecuado cumplimiento de esta tarea depende crucialmente del manteni-miento de la estabilidad financiera. La estabilidad financiera se entiende como una condición general en la cual el sistema financiero (establecimientos, mercados e infraestructuras): 1. Evalúa y administra los riesgos financieros de una manera que facilita el desempeño de la economía y la asignación eficiente de los recursos; 2. está en capacidad de absorber, disipar y mitigar de manera autónoma la materialización de los riesgos que pueda surgir como resultado de eventos adversos. Ete Reporte de Estabilidad Financiera cumple el objetivo de presentar la apreciación del Banco de la República sobre el desempeño reciente de los establecimientos de crédito y sus deudores, así como sobre los principales riesgos y vulnerabilidades que podrían tener algún efecto sobre la estabili-dad financiera de la economía colombiana. Con este objetivo se pretende in-formar a los participantes en los mercados financieros y al público, además de promover el debate público sobre las tendencias y los riesgos que atañen al sistema financiero. Los resultados aquí presentados sirven también a la autoridad monetaria como base para la toma de decisiones que permitan promover la estabilidad financiera en el contexto general de los objetivos de estabilidad de precios y estabilidad macroeconómica. Este Reporte se complementa con el Reporte de Sistemas de Pago publicado anualmente por el Banco de la República, en el cual se divulga la labor de seguimiento a las infraestructuras financieras de la economía colombiana.

Bullying and violence against transitioning children and youth within the Canadian educational system still continues to be a serious cause of stress for children. This paper supports a short documentary film (29 minutes), which includes interviews with children, parents, and teachers about a weeklong program called Gender Splendour that has been held for the past seven years at The Grove Community School in Toronto. Amid workshops during a week in April, non-binary-conforming and cisgender identifying children have the opportunity to ponder, question, and defy gender stereotypes, which are prevalent in society, culture, and the media. A background of the director of the film informs his trajectory as an activist communicator. In addition, some of his inspirational sources are included. Notions playing in the documentary related to activism, reflexive ethnography, performativity, and participatory dynamics, are explained. Producing a documentary on the subjects of sexuality and children surely poses difficulties related to ethics, consent, and representation, on which the author comments.

El objetivo de este informe es describir la evolución reciente de las líneas de crédito en moneda extranjera de los bancos colombianos y presentar los principales resultados de la última encuesta de endeudamiento externo y cupos, la cual fue aplicada por el Departamento de Estabilidad Financiera del Banco de la República a una muestra representativa de bancos comerciales que tienen líneas de crédito en moneda extranjera.

El fenotipo es el efecto acumulativo del genotipo (G), del ambiente (A) y su interacción (G x A). El ambiente es el factor que afecta en mayor medida el fenotipo debido a que varía entre localidades, temporadas y estaciones del año, mientras que los efectos de los genotipos son constantes. El objetivo de este trabajo fue identificar genotipos de berenjena (Solanum melongena L.) altamente productivos y fenotípicamente estables, con frutos aceptables para los mercados de exportación y nacional, calificados, respectivamente, de primera y segunda categoría, a partir del análisis de estabilidad mediante el modelo AMMI y el índice de superioridad (Pi) de Lin y Binns. Para el efecto se utilizaron variables asociadas con rendimientos de 15 genotipos de berenjena evaluados en tres ambientes de la región Caribe de Colombia. Los resultados mostraron que: (1) El rendimiento de frutos de primera y segunda categoría fueron significativos (P < 0.001) para la interacción genotipo x ambiente, (2) los materiales Corpoica (C) C015, C027, C035, C036 y C049 lo fueron para el rendimiento de primera categoría y C014, C025, C032, C040 y C049 para el rendimiento de segunda categoría, ya que se ubicaron cerca al cero del CP1, por tanto contribuyen en menor medida a la interacción genotipo x ambiente y son los materiales con el comportamiento más estable; y (3) los genotipos más estables según el Pi para el rendimiento de primera categoría fueron el C006, C026, C027, C035 y C040; y para el de segunda categoría fueron C014, C035, C040, C042 y C049; los cuales, en su mayoría, coinciden con los genotipos más estables y de mayor rendimiento de acuerdo al análisis AMMI.

Exposure describes elements which are imperiled by natural hazards and susceptible to damage. The affiliated vulnerability characterizes the likelihood to experience damage regarding a given level of hazard intensity. Frequently, the compilation of exposure information is the costliest component (in terms of time and labor) in risk assessment. Existing data sets and models often describe exposure in an aggregated manner, e.g., by relying on statistical/census data for given administrative entities. Nowadays, earth observation techniques allow to collect spatially continuous information for large geographic areas while enabling a high geometric and temporal resolution. In parallel, modern data interpretation tools based on Artificial Intelligence concepts enable the extraction of thematic information from such data with a high accuracy and detail. Consequently, we exploit measurements from the earth observation missions TanDEM-X and Sentinel-2, which collect data on a global scale, to characterize the built environment in terms of fundamental morphologic properties, namely built-up density and height. Subsequently, we use this information to constrain existing exposure data in a spatial disaggregation approach. Thereby, we compare different methods for disaggregation and evaluate how different resolution properties of the earth observation data affect the risk assessment result. Results are presented for the city of Santiago de Chile, Chile, which is prone to natural hazards such as earthquakes. We present loss estimations and corresponding sensivity with respect to the resolution properties of the exposure data used in the model. Thereby, it can be noted how loss estimations vary substantially and that aggregated exposure information underestimates losses in our scenarios. As such, this study underlines the benefits of deploying modern earth observation technologies for refined exposure estimation and related loss estimation.

In the face of the multiple shocks currently experienced by the domestic economy (resulting from the drop in oil prices and the appearance of a global pandemic), the Colombian financial system is in a position of sound solvency and adequate liquidity. At the same time, credit quality has been recovering and the exposure of credit institutions to firms with currency mismatches has declined relative to previous episodes of sudden drops in oil prices. These trends are reflected in the recent fading of red and blue tonalities in the performance and credit risk segments of the risk heatmaps in Graphs A and B.1 Naturally, the sudden, unanticipated change in macroeconomic conditions has caused the appearance of vulnerabilities for short-term financial stability. These vulnerabilities require close and continuous monitoring on the part of economic authorities. The main vulnerability is the response of credit and credit risk to a potential, temporarily extreme macroeconomic situation in the context of: (i) recently increased exposure of some banks to household sector, and (ii) reductions in net interest income that have led to a decline in the profitability of the banking business in the recent past. Furthermore, as a consequence of greater uncertainty and risk aversion, occasional problems may arise in the distribution of liquidity between agents and financial markets. With regards to local markets, spikes have been registered in the volatility of public and private fixed income securities in recent weeks that are consistent with the behavior of the international markets and have had a significant impact on the liquidity of those instruments (red portions in the most recent past of some market risk items on the map in Graph A). In order to adopt a forward-looking approach to those vulnerabilities, this Report presents a stress test that evaluates the resilience of credit institutions in the event of a hypothetical scenario thatseeks to simulate an extreme version of current macroeconomic conditions. The scenario assumes a hypothetical negative growth that is temporarily strong but recovers going into the middle of the coming year and has extreme effects on credit quality. The results suggest that credit institutions have the ability to withstand a significant deterioration in economic conditions in the short term. Even though there could be a strong impact on credit, liquidity, and profitability under the scenario being considered, aggregate capital ratios would probably remain at above their regulatory limits over the horizon of a year. In this context, the recent measures taken by both Banco de la República and the Office of the Financial Superintendent of Colombia that are intended to help preserve the financial stability of the Colombian economy become highly relevant. In compliance with its constitutional objectives and in coordination with the financial system’s security network, Banco de la República will continue to closely monitor the outlook for financial stability at this juncture and will make the decisions that are necessary to ensure the proper functioning of the economy, facilitate the flow of sufficient credit and liquidity resources, and further the smooth functioning of the payment system. Juan José Echavarría Governor

El objetivo de este informe es describir la evolución reciente de las líneas de crédito en moneda extranjera de los bancos colombianos y presentar los principales resultados de la última encuesta de endeudamiento externo y cupos, la cual fue aplicada por el Departamento de Estabilidad Financiera del Banco de la República a una muestra representativa de bancos comerciales que tienen líneas de crédito en moneda extranjera.

Background: In dementia, functional status depends on multiple factors in addition to cognition. Nutritional status is a potentially modifiable factor related to homeostasis and proper functioning of body systems and may contribute to cognitive and functional decline. Objective: This paper aims to analyze the association of malnutrition with the course of cognitive and functional decline in people living with dementia. Methods: This is an analysis of a longitudinal cohort study, the Dementia Study of Western Norway. Data of 202 patients diagnosed with mild dementia were analyzed; Alzheimer’s disease (AD) (n = 103), Lewy body dementia (LBD) (n = 74), and other dementias (OD) (n = 25). Cognition was assessed with the Mini-Mental State Examination and functional decline through the activities of daily living included in the Rapid Disability Rating Scale. The Global Leadership Initiative on Malnutrition Index was used to determine nutritional status. Associations of nutritional status with cognitive and functional decline were evaluated through adjusted linear mixed models. Results: At baseline, the prevalence of general malnutrition was 28.7%; 17.3% were classified as moderate malnutrition and 11.38% as severe malnutrition (there were no significant differences between AD and LBD). Malnutrition at diagnosis and over follow-up was a significant predictor of functional-decline, but not of cognitive decline. Conclusion: According to our results malnutrition was associated with faster functional loss but, not cognitive decline in older adults with dementia. A more comprehensive dementia approach including nutritional assessments could improve prognosis.

During a pandemic, the government requires active compliance by citizens. While these demands can be enforced with rewards and punishments, legitimacy allows the government to achieve the same results with greater cost effectiveness. In this article, we measure revealed legitimacy through support of three potential mitigation strategies against Covid19, when they are defended using expert endorsement, consultation by civil society, and mediation between opposing interests. We elicit approval of the supporting arguments and of the communication strategy. Our methodological choice was to randomly assign participants to either a non-conflicting priming or to one that emphasizes the risks involved, (e.g. connection between health and economy, uncertainty, and economic costs). The data come from an online experiment we conducted as part of a longitudinal study of several countries. The countries included are Italy, Spain, and the United Kingdom. The results show that the support of experts in non-controversial domains is preferred (consensus of value, low uncertainty, diffuse rents). Contrary to our hypotheses, we found that citizen deliberation is not preferred under high epistemic uncertainty, and mediation is either indifferent or not preferred under conflict of value and conflict of interest.

Purpose: This study aimed to determine the efficacy and safety of Oncoxin as an antitumoral supplement, and to describe its mechanism of action. Methods: We performed this scoping review according to the recommendations of the Joanna Briggs Institute and included patients older than 18 years-old who have any kind of tumor and receive Oncoxin as a supplement. We focused on the efficacy in terms of antitumoral properties, quality of life and survival, safety in terms of adverse events, and the mechanism of action. We did not limit for language or setting. We searched MEDLINE (Pubmed), EMBASE (Scopus), LILACS, and the Cochrane Central Register of Controlled Trials (CENTRAL) from inception to nowadays. Results: We found a promising increment of survival when taking Oncoxin as a supplementary treatment. Additionally, the quality of life increased in terms of Karnofsky and EORTC scales. Regarding the mechanism of action, studies suggest it modifies inflammatory mediators’ expression, as evidenced by the reduction of COX-2, IL-1β, IL-6, TNF-α, IL-1β, IL-12, and IFN-γ. Besides, it promotes an arrest in the progression of cells from G1 into S, along with an increase in p27 and a decrease in cyclin D1 and pRb. Conclusions: We found promising complementary effects of Oncoxin to the standard treatment of cancer patients in diverse scenarios, with putative robust mechanisms of action. In addition to clinically relevant impacts verified in clinical trials, as well as it decreases the levels of pro-inflammatory cytokines, it can also decrease cytokines with antitumor activity such as IFN-γ, which should be further explored in larger trials and the long term.

La presente investigación tiene como objetivo principal realizar una comparación entre dos metodologías para calcular el número máximo de visitantes que pueden ingresar diariamente a un área natural en donde se realiza turismo, para establecer las fortalezas y debilidades de cada una. Como caso de estudio se seleccionó la reserva Biológica El Encenillo ubicada en el municipio de Guasca, departamento de Cundinamarca – Colombia. Las metodologías utilizadas fueron la Capacidad De Carga Turística (CCT), ampliamente utilizada, pero que en la actualidad ha ido cayendo en desuso y se le tacha de subjetiva y el Cálculo de Acogida Turística Multicriterio – CATUM, que sigue un método basado en la ponderación de los factores de corrección mediante el Proceso Analítico Jerárquico (Analytic Hierarchy Process - AHP), aplicado en 3 niveles de consulta: Sui validatio, Scientatis validatio y Societatis validatio, como mecanismo para reducir la subjetividad. The main objective of this research is to carry out a comparison between two methodologies to calculate the maximum daily number of visitors that can enter a natural area where tourism is carried out, to establish the strengths and weaknesses of each of them. The biological reserve El Encenillo was selected as a case study. It is located in the municipality of Guasca, department of Cundinamarca - Colombia. The methodologies used were the Tourist Carrying Capacity (CCT), which was formerly widely used, but has now fallen into disuse and is considered to be subjective, and the Multi-criteria Tourism Hosting Calculation, which follows a method based on the weighting of correction factors through the Analytic Hierarchy Process (AHP), applied at 3 levels of consultation: Sui validatio, Scientatis validatio and Societatis validatio, as a mechanism to reduce subjectivity.

El daño ocasionado por una plaga es el resultado de la interacción de una planta susceptible a cualquier especie vegetal o animal o agente patógeno que en un ambiente favorable para su desarrollo conlleva al detrimento económico de la actividad productiva

El presente informe analiza los resultados de las encuestas anuales de estructura de financiamiento y de riesgo cambiario, las cuales tienen como propósito profundizar en el conocimiento sobre el financiamiento de las firmas y el uso de instrumentos derivados de tasa de cambio. Estas encuestas fueron aplicadas por el Banco de la República y Fedesarrollo a una muestra representativa de empresas

The aim of this scoping review was to identify knowledge gaps and to describe the current state of the research on the association between TMPRSS2 and the essential beta coronaviruses (Beta-CoVs) infection and the molecular mechanisms for this association. We searched MEDLINE (OVID), EMBASE, and the Cochrane Central Register of Controlled Trials (CENTRAL). We included 13 studies. Evidence shows an essential role of TMPRSS2 in Spike protein activation, entry, and spread into host cells. Co-expression of TMPRSS2 with cell surface receptors (ACE2 or DPP4) increased virus entry. This serine protease is involved in the formation of large syncytia between infected cells. TMPRSS2 cleaved the Spike protein of SARS-CoV, SARS-CoV-2, and MERS-CoV, and increased virus propagation. Accumulating evidence suggests that TMPRSS2 is an essential protease for virus replication. We highlighted its critical molecular role in membrane fusion and the impact in viral mRNA replication, then promoting/driving pathogenesis and resistance. Supplementary Information The online version contains supplementary material available at 10.1007/s00203-021-02727-3.

Feo is the most widely conserved system for ferrous iron transport in prokaryotes, and it is important for virulence in some pathogens. However, its mechanism of iron transport is not fully understood. In this study, we used full-length Vibrio cholerae FeoB (VcFeoB) as a model system to study whether its enzymatic activity is affected by regulatory factors commonly associated with FeoB proteins from other species or with G-proteins that have homology to FeoB. VcFeoB showed a higher rate of hydrolysis of both ATP and GTP than its N-terminal domain alone; likewise, ions such as K+ and Fe2+ did not modulate its nucleotide hydrolysis. We also showed that the three V. cholerae Feo proteins (FeoA, FeoB, and FeoC) work in a 1 : 1 : 1 molar ratio in vivo. Although both FeoA and FeoC are required for Feo-mediated iron transport, neither of these proteins affected the VcFeoB NTPase rate. These results are consistent with an active transport mechanism independent of stimulatory factors and highlight the importance of using full-length FeoB proteins as a reliable proxy to study Feo-mediated iron transport in vitro.

El sistema financiero colombiano no ha sufrido mayores traumatismos estructurales durante estos meses de profunda contracción económica, y ha continuado prestando con normalidad sus funciones básicas, facilitando la respuesta de la economía a condiciones extremas. Ello es el resultado de la solidez de las entidades financieras al inicio de la crisis, reflejada en elevados indicadores de liquidez y solvencia, y de la oportuna respuesta de distintas entidades. El Banco de la República redujo 250 puntos sus tasas de interés de política, hasta 1,75%, el menor nivel desde la creación del nuevo Banco independiente en 1991, y otorgó amplia liquidez transitoria y permanente, tanto en pesos como en moneda extranjera. Por su parte, la Superintendencia Financiera de Colombia adoptó medidas prudenciales para facilitar cambios en las condiciones de los créditos vigentes y reglas transitorias de calificación y constitución de provisiones. Finalmente, el Gobierno Nacional expandió las transferencias y los programas de créditos garantizados a la economía. El acervo de crédito real (i.e. descontando la inflación) en la economía supera hoy en 4% el de hace 12 meses, con crecimientos especialmente marcados en la cartera de vivienda (5,6%) y comercial (4,7%) (2,3% en consumo y -0,1% en microcrédito), pero ha habido cambios importantes en el tiempo. En los meses iniciales de la cuarentena las firmas elevaron fuertemente sus demandas por liquidez, y los consumidores las redujeron, mientras que en los meses recientes la dinámica del crédito a las firmas ha tendido a desacelerarse, y la del crédito a los consumidores y a la vivienda ha crecido. El sistema financiero ha respondido satisfactoriamente a la evolución de la demanda relativa de cada grupo o sector, y el crédito posiblemente crecerá a tasas altas en 2021 si el PIB crece a tasas cercanas a 4,6% como lo espera el equipo técnico del Banco, pero los pronósticos son altamente inciertos. Luego de la fuerte cuarentena implementada por las autoridades en Colombia, las turbulencias observadas en marzo y comienzos de abril, evidentes en el enrojecimiento repentino de variables macroeconómicas en el mapa de riesgos del Gráfico A , y la caída en los precios del petróleo y el carbón (nótese las altas volatilidades registradas en la región de riesgo de mercado del Gráfico A), los mercados financieros locales se estabilizaron con relativa rapidez. En esta estabilización tuvo un papel determinante la respuesta de política creíble y sostenida del Banco de la República en lo referente a la provisión de liquidez, con una fuerte expansión de operaciones repo (y variaciones en montos, plazos, contrapartes e instrumentos admisibles), la compra definitiva de deuda pública y privada, y la reducción del encaje de los bancos. En este sentido, hoy se observa abundante liquidez agregada y mejoras importantes en la posición de liquidez de los fondos de inversión colectiva. En este contexto, el principal factor de incertidumbre para la estabilidad financiera en el corto plazo continúa siendo el alto grado de incertidumbre que rodea a la calidad de la cartera. En primer lugar, es incierta la trayectoria futura del número de contagiados y fallecidos como consecuencia del virus y la eventual necesidad de medidas sanitarias adicionales. Por tal razón, también existe incertidumbre sobre la senda de recuperación de la economía en el corto y mediano plazo. En segundo lugar, es incierto el grado en que el choque actual se reflejará en la calidad de la cartera una vez se materialice el riesgo en los estados financieros. De momento, el mapa de riesgos (Gráfico B) indica que la cartera vencida y la cartera riesgosa no han mostrado mayores deterioros, pero la experiencia histórica indica que períodos de fuerte desaceleración económica tienden a coincidir eventualmente con aumentos de la cartera vencida: los cálculos incluidos en este reporte sugieren que el impacto de la recesión sobre la calidad del crédito en el corto plazo podría ser significativo. Ello es particularmente preocupante teniendo en cuenta que la rentabilidad de los establecimientos de crédito ha venido reduciéndose en meses recientes, lo cual podría afectar su capacidad para otorgar crédito al sector real de la economía. Con el fin de adoptar un enfoque prospectivo de cara a las vulnerabilidades identificadas, este reporte presenta varios ejercicios de sensibilidad (stress tests) que evalúan la resiliencia de la liquidez y la solvencia de los establecimientos de crédito y de los fondos de inversión colectiva ante escenarios hipotéticos que buscan aproximarse a una versión extrema de las condiciones económicas actuales. Los resultados sugieren que, en tales escenarios, se observarían fuertes impactos sobre el volumen de crédito y la rentabilidad de los establecimientos de crédito, aunque los indicadores agregados de solvencia total y básica permanecerían en niveles superiores a los límites regulatorios durante el horizonte de los ejercicios. Al tiempo, los ejercicios resaltan la alta capacidad que tiene la liquidez del sistema para enfrentar escenarios adversos. En cumplimiento de sus objetivos constitucionales y en coordinación con la red de seguridad del sistema financiero, el Banco de la República continuará monitoreando de cerca el panorama de estabilidad financiera en esta coyuntura y tomará aquellas decisiones que sean necesarias para garantizar el adecuado funcionamiento de la economía, facilitar los flujos de recursos suficientes de crédito y liquidez, y promover el buen funcionamiento del sistema de pagos. Juan José Echavarría Gerente General

El objetivo de este informe es describir la evolución reciente de las líneas de crédito en moneda extranjera de los bancos colombianos y presentar los principales resultados de la última encuesta de endeudamiento externo y cupos, la cual fue aplicada por el Departamento de Estabilidad Financiera del Banco de la República a una muestra representativa de bancos comerciales que tienen líneas de crédito en moneda extranjera.

Monitorear el riesgo de credito es fundamental para preservar la estabilidad del sistema financiero. El analisis que se presenta en este informe utiliza, para cada modalidad de credito, indicadores como el de calidad por riesgo; el indicador de calidad por mora (ICM); el indicador de calidad por riesgo por operaciones; el indicador de calidad por mora por operaciones; asi como la probabilidad de que un determinado credito migre hacia una mejor o hacia una peor calificacion crediticia.

Objective To determine the efficacy and harms of using tranexamic acid (TXA) versus placebo/no intervention to reduce blood loss and the need for transfusion in children undergoing surgical correction of craniosynostosis. Methods We searched MEDLINE (OVID), EMBASE, LILACS, CENTRAL, and other sources. We included clinical trials, prospective, retrospective observational studies, case-control studies, and cohort studies. The primary outcomes were blood loss and the need for a transfusion, and secondary outcomes were hemoglobin, hematocrit, and adverse effects. We assessed the risk of bias with the Cochrane Collaboration tool. We performed the statistical analysis in R and reported information about the mean difference (MD) with a 95% confidence interval (CI). We evaluated heterogeneity with the I2 test. We produced forest plots to show the amount of evidence available for each outcome and made subgroup analyses. Results We included 11 studies in qualitative and quantitative analysis accounting for 752 patients. In general, the risk of all bias was assessed as low for non-randomized studies, and we found high performance and detection bias in one randomized study. TXA significantly reduced blood loss and need for transfusion compared to placebo/no intervention with an MD of -15.47 (95%CI -23.82, -7.11) and -8.18 (95%CI -12.24, -4.11), respectively. These differences were maintained regardless of the type of study, secondary outcomes also favored TXA, and there was no report of adverse effects. Conclusions TXA reduces blood loss and the need for transfusion when compared to placebo/no intervention. The available studies on this topic suggest its use in these patients and its implementation in surgery protocols.

The purpose of this research is to study the welfare impact on consumption that lifecycle investors constrained to make compulsory contributions into a pension fund will get by choosing a multifund. The use of simulation techniques is applied to a life cycle investment model designed to fit the situation of the Colombian private pension system. It shows the importance of combining the percentage of investments in equity in the pension fund with the structure of human capital in order to determine which investment vehicle individuals should be chosen in order to save for retirement.

Objective: To explore the association between educational level and the scores obtained in each of the domains of the Montreal Cognitive Assessment test. Methods: This is a secondary analysis of the SABE/2012 Bogota survey; a cross-sectional study including 2000 subjects aged ≥60years. The MoCA test was the dependent variable and was stratified by cognitive domains, incorrect answers and scores were considered. Educational level was assessed through years of formal education. Age, sex and selected medical conditions were also included to adjust the multivariate models. Bivariate analyses, fitted logistic and linear regression models were employed for analyzing association between these variables. Results: The proportion of incorrect answers increased as schooling years decreased and as age increased. In the multivariate analysis, visuospatial and executive function were the most affected domains. Educational level displayed less influence than age on short memory-recall task (standardized beta 0.19 vs -0.24). Educational level showed a greater influence than age on no-memory tasks (the sum of all other domains; standardized beta 0.50 vs -0.29). Conclusions: It seems logical to consider that performance in most domains of the MoCA is influenced by years of education. Therefore, low scores on these tasks could lead to low total MoCA scores and thus to bias and over diagnosis of cognitive impairment in patients with lower educational levels. Memory-recall domain is not affected much by education and applying it separately could be useful in patients with low educational level in whom we suspect memory impairment.