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101. The relationship of hypertension to coronary atherosclerosis and cardiac events in patients with coronary CT angiography

Author

Nakanishi, Rine, Baskaran, Lohendran, Gransar, Heidi, Budoff, Matthew J., Achenbach, Stephan, Al-Mallah, Mouaz, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J. W., DeLago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Cury, Ricardo, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Kaufmann, Philipp A., Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Marques, Hugo, Pontone, Gianluca, Andreini, Daniele, Rubinshtein, Ronen, Bax, Jeroen, Jones, Erica, Hindoyan, Niree, Gomez, Millie, Lin, Fay Y., Min, James K., and Berman, Daniel S.

Subjects
Male, Computed Tomography Angiography, International Cooperation, Myocardial Ischemia, Coronary Artery Disease, Middle Aged, Coronary Angiography, Prognosis, Risk Assessment, Severity of Illness Index, Article, Outcome and Process Assessment, Health Care, Risk Factors, Hypertension, Humans, Female, Prospective Studies, Registries, Aged, Proportional Hazards Models
Abstract

Hypertension is an atherosclerosis factor and is associated with cardiovascular risk. We investigated the relationship between hypertension and the presence, extent, and severity of coronary atherosclerosis in coronary computed tomographic angiography and cardiac events risk. Of 17 181 patients enrolled in the CONFIRM registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry) who underwent ≥64-detector row coronary computed tomographic angiography, we identified 14 803 patients without known coronary artery disease. Of these, 1434 hypertensive patients were matched to 1434 patients without hypertension. Major adverse cardiac events risk of hypertension and non-hypertensive patients was evaluated with Cox proportional hazards models. The prognostic associations between hypertension and no-hypertension with increasing degree of coronary stenosis severity (nonobstructive or obstructive ≥50%) and extent of coronary artery disease (segment involvement score of 1-5,5) was also assessed. Hypertension patients less commonly had no coronary atherosclerosis and more commonly had nonobstructive and 1-, 2-, and 3-vessel disease than the no-hypertension group. During a mean follow-up of 5.2±1.2 years, 180 patients experienced cardiac events, with 104 (2.0%) occurring in the hypertension group and 76 (1.5%) occurring in the no-hypertension group (hazard ratios, 1.4; 95% confidence intervals, 1.0-1.9). Compared with no-hypertension patients without coronary atherosclerosis, hypertension patients with no coronary atherosclerosis and obstructive coronary disease tended to have higher risk of cardiac events. Similar trends were observed with respect to extent of coronary artery disease. Compared with no-hypertension patients, hypertensive patients have increased presence, extent, and severity of coronary atherosclerosis and tend to have an increase in major adverse cardiac events.

Published
2017

103. Clinical risk factors and atherosclerotic plaque extent to define risk for major events in patients without obstructive coronary artery disease: the long-term coronary computed tomography angiography CONFIRM registry.

Author

Rosendael, Alexander R van, Bax, A Maxim, Smit, Jeff M, Hoogen, Inge J van den, Ma, Xiaoyue, Al'Aref, Subhi, Achenbach, Stephan, Al-Mallah, Mouaz H, Andreini, Daniele, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J W, Cury, Ricardo C, DeLago, Augustin, Feuchtner, Gudrun, and Hadamitzky, Martin

Subjects
ATHEROSCLEROSIS, CARDIOVASCULAR diseases risk factors, COMPUTED tomography, CONFIDENCE intervals, CORONARY disease, DIABETES, HYPERTENSION, RISK assessment, BODY mass index, REVASCULARIZATION (Surgery), DESCRIPTIVE statistics
Abstract

Aims In patients without obstructive coronary artery disease (CAD), we examined the prognostic value of risk factors and atherosclerotic extent. Methods and results Patients from the long-term CONFIRM registry without prior CAD and without obstructive (≥50%) stenosis were included. Within the groups of normal coronary computed tomography angiography (CCTA) (N  = 1849) and non-obstructive CAD (N  = 1698), the prognostic value of traditional clinical risk factors and atherosclerotic extent (segment involvement score, SIS) was assessed with Cox models. Major adverse cardiac events (MACE) were defined as all-cause mortality, non-fatal myocardial infarction, or late revascularization. In total, 3547 patients were included (age 57.9 ± 12.1 years, 57.8% male), experiencing 460 MACE during 5.4 years of follow-up. Age, body mass index, hypertension, and diabetes were the clinical variables associated with increased MACE risk, but the magnitude of risk was higher for CCTA defined atherosclerotic extent; adjusted hazard ratio (HR) for SIS >5 was 3.4 (95% confidence interval [CI] 2.3–4.9) while HR for diabetes and hypertension were 1.7 (95% CI 1.3–2.2) and 1.4 (95% CI 1.1–1.7), respectively. Exclusion of revascularization as endpoint did not modify the results. In normal CCTA, presence of ≥1 traditional risk factors did not worsen prognosis (log-rank P  = 0.248), while it did in non-obstructive CAD (log-rank P  = 0.025). Adjusted for SIS, hypertension and diabetes predicted MACE risk in non-obstructive CAD, while diabetes did not increase risk in absence of CAD (P -interaction = 0.004). Conclusion Among patients without obstructive CAD, the extent of CAD provides more prognostic information for MACE than traditional cardiovascular risk factors. An interaction was observed between risk factors and CAD burden, suggesting synergistic effects of both. [ABSTRACT FROM AUTHOR]

Published
2020
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104. Prognostic value of chronic total occlusions detected on coronary computed tomographic angiography

Author

Opolski, Maksymilian P, primary, Gransar, Heidi, additional, Lu, Yao, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz H, additional, Andreini, Daniele, additional, Bax, Jeroen J, additional, Berman, Daniel S, additional, Budoff, Matthew J, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin JW, additional, Cury, Ricardo C, additional, DeLago, Augustin, additional, Feuchtner, Gudrun M, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp A, additional, Kim, Yong-Jin, additional, Leipsic, Jonathon A, additional, Maffei, Erica C, additional, Marques, Hugo, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Rubinshtein, Ronen, additional, Shaw, Leslee J, additional, Villines, Todd C, additional, Gomez, Millie, additional, Jones, Erica C, additional, Peña, Jessica M, additional, Min, James K, additional, and Lin, Fay Y, additional

Published
2018
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105. Current but not past smoking increases the risk of cardiac events: insights from coronary computed tomographic angiography

Author

Nakanishi, Rine, Berman, Daniel S., Budoff, Matthew J., Gransar, Heidi, Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor Y., Chinnaiyan, Kavitha, Chow, Benjamin J.W., Cury, Ricardo, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Jörg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A., Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Min, James K., Nakanishi, Rine, Berman, Daniel S., Budoff, Matthew J., Gransar, Heidi, Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Cheng, Victor Y., Chinnaiyan, Kavitha, Chow, Benjamin J.W., Cury, Ricardo, Delago, Augustin, Hadamitzky, Martin, Hausleiter, Jörg, Feuchtner, Gudrun, Kim, Yong-Jin, Kaufmann, Philipp A., Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, and Min, James K.

Abstract

Aims We evaluated coronary artery disease (CAD) extent, severity, and major adverse cardiac events (MACEs) in never, past, and current smokers undergoing coronary CT angiography (CCTA). Methods and results We evaluated 9456 patients (57.1 ± 12.3 years, 55.5% male) without known CAD (1588 current smokers; 2183 past smokers who quit ≥3 months before CCTA; and 5685 never smokers). By risk-adjusted Cox proportional-hazards models, we related smoking status to MACE (all-cause death or non-fatal myocardial infarction). We further performed 1:1:1 propensity matching for 1000 in each group evaluate event risk among individuals with similar age, gender, CAD risk factors, and symptom presentation. During a mean follow-up of 2.8 ± 1.9 years, 297 MACE occurred. Compared with never smokers, current and past smokers had greater atherosclerotic burden including extent of plaque defined as segments with any plaque (2.1 ± 2.8 vs. 2.6 ± 3.2 vs. 3.1 ± 3.3, P < 0.0001) and prevalence of obstructive CAD [1-vessel disease (VD): 10.6% vs. 14.9% vs. 15.2%, P < 0.001; 2-VD: 4.4% vs. 6.1% vs. 6.2%, P = 0.001; 3-VD: 3.1% vs. 5.2% vs. 4.3%, P < 0.001]. Compared with never smokers, current smokers experienced higher MACE risk [hazard ratio (HR) 1.9, 95% confidence interval (CI) 1.4-2.6, P < 0.001], while past smokers did not (HR 1.2, 95% CI 0.8-1.6, P = 0.35). Among matched individuals, current smokers had higher MACE risk (HR 2.6, 95% CI 1.6-4.2, P < 0.001), while past smokers did not (HR 1.3, 95% CI 0.7-2.4, P = 0.39). Similar findings were observed for risk of all-cause death. Conclusion Among patients without known CAD undergoing CCTA, current and past smokers had increased burden of atherosclerosis compared with never smokers; however, risk of MACE was heightened only in current smokers

Published
2017

106. Gender differences in the prevalence, severity, and composition of coronary artery disease in the young: a study of 1635 individuals undergoing coronary CT angiography from the prospective, multinational confirm registry

Author

Otaki, Yuka, Gransar, Heidi, Cheng, Victor Y., Dey, Damini, Labounty, Troy, Lin, Fay Y., Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J.W., Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Cury, Ricardo C., Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Berman, Daniel S., Min, James K., Otaki, Yuka, Gransar, Heidi, Cheng, Victor Y., Dey, Damini, Labounty, Troy, Lin, Fay Y., Achenbach, Stephan, Al-Mallah, Mouaz, Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin J.W., Delago, Augustin, Hadamitzky, Martin, Hausleiter, Joerg, Kaufmann, Philipp, Maffei, Erica, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison, Cury, Ricardo C., Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Berman, Daniel S., and Min, James K.

Abstract

Objective Prior studies examining coronary atherosclerosis in the young have been limited by retrospective analyses in small cohorts. We examined the relationship between cardiovascular risk factors (RFs) and prevalence and severity of coronary atherosclerosis in a large, prospective, multinational registry of consecutive young individuals undergoing coronary computerized tomographic angiography (CCTA). Method and results Of 27 125 patients undergoing CCTA, 1635 young (<45 years) individuals without known coronary artery disease (CAD) or coronary anomalies were identified. Coronary plaque was assessed for any CAD, obstructive CAD (≥50% stenosis), and presence of calcified plaque (CP) and non-calcified plaque (NCP). Among 1635 subjects (70% men, age 38 ± 6 years), any CAD, obstructive CAD, CP, and NCP were observed in 19, 4, 5, and 8%, respectively. Compared with women, men demonstrated higher rates of any CAD (21 vs. 12%, P < 0.001), CP (6 vs. 3%, P = 0.01), and NCP (9 vs. 5%, P = 0.008), although no difference was observed for rates of obstructive CAD (5 vs. 4%, P = 0.46). Any CAD, obstructive CAD, and NCP were higher for young individuals with diabetes, hypertension, dyslipidaemia, current smoking, or family history of CAD; while only diabetes and dyslipidaemia were associated with CP. Increasing cardiovascular RFs was associated with a greater prevalence and extent and severity of CAD, with individuals with 0, 1, 2, ≥3 RFs manifesting a dose-response increase in any CAD (P < 0.001, for trend), obstructive CAD (P < 0.001, for trend), NCP (P < 0.001, for trend), and CP (P < 0.001, for trend). In multivariable analysis adjusting for sex and cardiovascular RFs, male sex was the strongest predictor for any CAD (odds ratio [OR] = 1.95, 95% confidence interval [CI] = 1.43-2.66, P < 0.001), CP (OR = 1.46, 95% CI = 1.08-1.98, P = 0.01), and NCP (OR = 1.33, 95% CI = 1.06-1.67, P = 0.01); family history of CAD was the strongest predictor for obstructive CAD (OR = 2.71, 95%

Published
2017

107. Coronary dominance and prognosis in patients undergoing coronary computed tomographic angiography: results from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry

Author

Gebhard, Catherine, Fuchs, Tobias A., Stehli, Julia, Gransar, Heidi, Berman, Daniel S., Budoff, Matthew J., Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha M., Chow, Benjamin J. W., Cury, Ricardo C., Delago, Augustin, Gomez, Millie J., Hadamitzky, Martin, Hausleiter, Joerg, Hindoyan, Niree, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison M., Min, James K., Kaufmann, Philipp A., Gebhard, Catherine, Fuchs, Tobias A., Stehli, Julia, Gransar, Heidi, Berman, Daniel S., Budoff, Matthew J., Achenbach, Stephan, Al-Mallah, Mouaz, Andreini, Daniele, Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha M., Chow, Benjamin J. W., Cury, Ricardo C., Delago, Augustin, Gomez, Millie J., Hadamitzky, Martin, Hausleiter, Joerg, Hindoyan, Niree, Feuchtner, Gudrun, Kim, Yong-Jin, Leipsic, Jonathon, Lin, Fay Y., Maffei, Erica, Pontone, Gianluca, Raff, Gilbert, Shaw, Leslee J., Villines, Todd C., Dunning, Allison M., Min, James K., and Kaufmann, Philipp A.

Abstract

Aims Coronary computed tomographic angiography (CCTA) has become an important tool for non-invasive diagnosis of coronary artery disease (CAD). Coronary dominance can be assessed by CCTA; however, the predictive value of coronary dominance is controversially discussed. The aim of this study was to evaluate the prevalence and prognosis of coronary dominance in a large prospective, international multicentre cohort of patients undergoing CCTA. Methods and results The study population consisted of 6382 patients with or without CAD (47% females, 53% males, mean age 56.9 ± 12.3 years) who underwent CCTA and were followed over a period of 60 months. Right or left coronary dominance was determined. Right dominance was present in 91% (n = 5817) and left in 9% (n = 565) of the study population. At the end of follow-up, outcome in patients with obstructive CAD (>50% luminal stenosis) and right dominance was similar compared with patients with left dominance [hazard ratio (HR) 0.46, 95% CI 0.16-1.32, P = 0.15]. Furthermore, no differences were observed for the type of coronary dominance in patients with non-obstructive CAD (HR 0.95, 95% CI 0.41-2.21, P = 0.8962) or normal coronary arteries (HR 1.04, 95% CI 0.68-1.59, P = 0.9). Subgroup analysis in patients with left main disease revealed an elevated hazard of the combined endpoint for left dominance (HR 6.45, 95% CI 1.66-25.0, P = 0.007), but not for right dominance. Conclusion In our study population, survival after 5 years of follow-up did not differ significantly between patients with left or right coronary dominance. Thus, assessment of coronary vessel dominance by CCTA may not enhance risk stratification in patients with normal coronary arteries or obstructive CAD, but may add prognostic information for specific subpopulations

Published
2017

108. Prevalence and severity of coronary artery disease and adverse events among symptomatic patients with coronary artery calcification scores of zero undergoing coronary computed tomography angiography: results from the CONFIRM (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter) registry

Author

Villines Todd C, Hulten Edward A, Shaw Leslee J, Goyal Manju, Dunning Allison, Achenbach Stephan, Al-Mallah Mouaz, Berman Daniel S, Budoff Matthew J, Cademartiri Filippo, Callister Tracy Q, Chang Hyuk-Jae, Cheng Victor Y, Chinnaiyan Kavitha, Chow Benjamin J W, Delago Augustin, Hadamitzky Martin, Hausleiter Jörg, Kaufmann Philipp, Lin Fay Y, Maffei Erica, Raff Gilbert L, Min James K, and CONFIRM Registry Investigators

Subjects
nutritional and metabolic diseases, cardiovascular diseases
Abstract

OBJECTIVES The purpose of this study was to describe the prevalence and severity of coronary artery disease (CAD) in relation to prognosis in symptomatic patients without coronary artery calcification (CAC) undergoing coronary computed tomography angiography (CCTA). BACKGROUND The frequency and clinical relevance of CAD in patients without CAC are unclear. METHODS We identified 10037 symptomatic patients without CAD who underwent concomitant CCTA and CAC scoring. CAD was assessed as 0 had a sensitivity specificity and negative and positive predictive values for stenosis =50 of 89 59 96 and 29 respectively. During a median of 2.1 years there was no difference in mortality among patients with a CAC score of 0 irrespective of obstructive CAD. Among 8907 patients with follow up for the composite endpoint 3.9 with a CAC score of 0 and =50 stenosis experienced an event (hazard ratio: 5.7; 95 confidence interval: 2.5 to 13.1; p < 0.001) compared with 0.8 of patients with a CAC score of 0 and no obstructive CAD. Receiver operator characteristic curve analysis demonstrated that the CAC score did not add incremental prognostic information compared with CAD extent on CCTA for the composite endpoint (CCTA area under the curve = 0.825; CAC + CCTA area under the curve = 0.826; p = 0.84). CONCLUSIONS In symptomatic patients with a CAC score of 0 obstructive CAD is possible and is associated with increased cardiovascular events. CAC scoring did not add incremental prognostic information to CCTA.

Published
2011
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109. Incremental prognostic value of coronary computed tomography angiography over coronary calcium scoring for major adverse cardiac events in elderly asymptomatic individuals

Author

Han, Donghee, primary, Hartaigh, Bríain Ó, additional, Gransar, Heidi, additional, Lee, Ji Hyun, additional, Rizvi, Asim, additional, Baskaran, Lohendran, additional, Schulman-Marcus, Joshua, additional, Dunning, Allison, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz H, additional, Berman, Daniel S, additional, Budoff, Matthew J, additional, Cademartiri, Filippo, additional, Maffei, Erica, additional, Callister, Tracy Q, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J W, additional, DeLago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp A, additional, Raff, Gilbert, additional, Shaw, Leslee J, additional, Villines, Todd C, additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, Feuchtner, Gudrun, additional, Cury, Ricardo C, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Marques, Hugo, additional, Rubinshtein, Ronen, additional, Hindoyan, Niree, additional, Jones, Erica C, additional, Gomez, Millie, additional, Lin, Fay Y, additional, Chang, Hyuk-Jae, additional, and Min, James K, additional

Published
2017
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110. Prognostic implications of coronary artery calcium in the absence of coronary artery luminal narrowing

Author

Cho, Iksung, primary, ó Hartaigh, Bríain, additional, Gransar, Heidi, additional, Valenti, Valentina, additional, Lin, Fay Y., additional, Achenbach, Stephan, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Callister, Tracy Q., additional, Al-Mallah, Mouaz H., additional, Cademartiri, Filippo, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Dunning, Allison M., additional, DeLago, Augustin, additional, Villines, Todd C., additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Leipsic, Jonathon, additional, Shaw, Leslee J., additional, Kaufmann, Philipp A., additional, Cury, Ricardo C., additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Maffei, Erica, additional, Raff, Gilbert, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Chang, Hyuk-Jae, additional, and Min, James K., additional

Published
2017
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112. Prognostic and therapeutic implications of statin and aspirin therapy in individuals with nonobstructive coronary artery disease: results from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter registry) registry

Author

Chow, Benjamin JW, Small, Gary, Yam, Yeung, Chen, Li, McPherson, Ruth, Achenbach, Stephan, Al-Mallah, Mouaz, Berman, Daniel S, Budoff, Matthew J, Cademartiri, Filippo, Callister, Tracy Q, Chang, Hyuk-Jae, Cheng, Victor Y, Chinnaiyan, Kavitha, Cury, Ricardo, Delago, Augustin, Dunning, Allison, Feuchtner, Gundrun, Hadamitzky, Martin, Hausleiter, Jörg, Karlsberg, Ronald P, Kaufmann, Philipp A, Kim, Yong-Jin, Leipsic, Jonathon, LaBounty, Troy, Lin, Fay, Maffei, Erica, Raff, Gilbert L, Shaw, Leslee J, Villines, Todd C, Min, James K, and CONFIRM Investigators

Subjects
Male, Time Factors, Coronary Artery Disease, Kaplan-Meier Estimate, Cardiorespiratory Medicine and Haematology, Coronary Angiography, Cardiovascular, Severity of Illness Index, Risk Factors, Odds Ratio, Registries, Prospective Studies, Tomography, screening and diagnosis, Middle Aged, X-Ray Computed, Primary Prevention, Europe, Detection, Treatment Outcome, Heart Disease, 6.1 Pharmaceuticals, Female, Patient Safety, 4.2 Evaluation of markers and technologies, Adult, Canada, Asia, aspirin, Clinical Sciences, CONFIRM Investigators, Predictive Value of Tests, Clinical Research, Humans, Heart Disease - Coronary Heart Disease, Proportional Hazards Models, Aged, Coronary Stenosis, statin, Evaluation of treatments and therapeutic interventions, coronary atherosclerosis, Protective Factors, Atherosclerosis, mortality, United States, Good Health and Well Being, Cardiovascular System & Hematology, Multivariate Analysis, prognosis, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Platelet Aggregation Inhibitors
Abstract

ObjectiveWe sought to examine the risk of mortality associated with nonobstructive coronary artery disease (CAD) and to determine the impact of baseline statin and aspirin use on mortality.Approach and resultsCoronary computed tomographic angiography permits direct visualization of nonobstructive CAD. To date, the prognostic implications of nonobstructive CAD and the potential benefit of directing therapy based on nonobstructive CAD have not been carefully examined. A total of 27 125 consecutive patients who underwent computed tomographic angiography (12 enrolling centers and 6 countries) were prospectively entered into the COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter (CONFIRM) registry. Patients, without history of previous CAD or obstructive CAD, for whom baseline statin and aspirin use was available were analyzed. Each coronary segment was classified as normal or nonobstructive CAD (1%-49% stenosis). Patients were followed up for a median of 27.2 months for all-cause mortality. The study comprised 10 418 patients (5712 normal and 4706 with nonobstructive CAD). In multivariable analyses, patients with nonobstructive CAD had a 6% (95% confidence interval, 1%-12%) higher risk of mortality for each additional segment with nonobstructive plaque (P=0.021). Baseline statin use was associated with a reduced risk of mortality (hazard ratio, 0.44; 95% confidence interval, 0.28-0.68; P=0.0003), a benefit that was present for individuals with nonobstructive CAD (hazard ratio, 0.32; 95% confidence interval, 0.19-0.55; P

Published
2015

113. A 15-year warranty period for asymptomatic individuals without coronary artery calcium. A prospective follow-up of 9,715 individuals

Author

Valenti, Valentina, ó Hartaigh, Bríain, Heo, Ran, Cho, Iksung, Schulman-Marcus, Joshua, Gransar, Heidi, Truong, Quynh A., Shaw, Leslee J., Knapper, Joseph, Kelkar, Anita A., Sandesara, Pratik, Lin, Fay Y., Sciarretta, Sebastiano, Chang, Hyuk-Jae, Callister, Tracy Q., and Min, James K.

Subjects
nuclear medicine and imaging, cardiology and cardiovascular medicine, warranty period, computed tomography, coronary artery calcium, mortality, prognosis, radiology, nuclear medicine and imaging, nutritional and metabolic diseases, cardiovascular diseases, radiology
Abstract

ObjectivesThe aim of this study was to examine the long-term prognosis in asymptomatic individuals with a coronary artery calcium (CAC) score of 0 and its associated warranty period.BackgroundEmerging evidence supports a CAC score of 0 as a favorable cardiovascular short-to intermediate-term prognostic factor.MethodsA total of 9,715 individuals undergoing CAC imaging were stratified by age, Framingham risk score (FRS), and National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) categories and followed for a mean of 14.6 years (range 12.9 to 16.8 years). Cox regression, area under the receiver-operating characteristic curve, and net reclassification information were used to assess all-cause mortality, discrimination, and reclassification of a CAC score of 0 compared with the FRS and NCEP ATP III, respectively. A warranty period was pre-defined as

Published
2015

114. Prognostic value of chronic total occlusions detected on coronary computed tomographic angiography.

Author

Opolski, Maksymilian P., Gransar, Heidi, Yao Lu, Achenbach, Stephan, Al-Mallah, Mouaz H., Andreini, Daniele, Bax, Jeroen J., Berman, Daniel S., Budoff, Matthew J., Cademartiri, Filippo, Callister, Tracy Q., Chang, Hyuk-Jae, Chinnaiyan, Kavitha, Chow, Benjamin JW., Cury, Ricardo C., DeLago, Augustin, Feuchtner, Gudrun M., Hadamitzky, Martin, Hausleiter, Joerg, and Kaufmann, Philipp A.

Subjects
CORONARY angiography, ANGIOGRAPHY, MYOCARDIAL infarction, CORONARY arteries, CORONARY disease, CORONARY heart disease complications, CORONARY heart disease treatment, COMPARATIVE studies, RESEARCH methodology, MEDICAL cooperation, MORTALITY, MYOCARDIAL revascularization, PROGNOSIS, RESEARCH, RESEARCH funding, RISK assessment, EVALUATION research, PREDICTIVE tests, ACQUISITION of data, SEVERITY of illness index
Abstract

Objective: Data describing clinical relevance of chronic total occlusion (CTO) identified by coronary CT angiography (CCTA) have not been reported to date. We investigated the prognosis of CTO on CCTA.Methods: We identified 22 828 patients without prior known coronary artery disease (CAD), who were followed for a median of 26 months. Based on CCTA, coronary lesions were graded as normal (no atherosclerosis), non-obstructive (1%-49%), moderate-to-severe (50%-99%) or totally occluded (100%). All-cause mortality, and major adverse cardiac events defined as mortality, non-fatal myocardial infarction and late coronary revascularisation (≥90 days after CCTA) were assessed.Results: The distribution of patients with normal coronaries, non-obstructive CAD, moderate-to-severe CAD and CTO was 10 034 (44%), 7965 (34.9%), 4598 (20.1%) and 231 (1%), respectively. The mortality rate per 1000 person-years of CTO patients was non-significantly different from patients with moderate-to-severe CAD (22.95; 95% CI 12.71 to 41.45 vs 14.46; 95% CI 12.34 to 16.94; p=0.163), and significantly higher than of those with normal coronaries and non-obstructive CAD (p<0.001 for both). Among 14 382 individuals with follow-up for the composite end point, patients with CTO had a higher rate of events than those with moderate-to-severe CAD (106.56; 95% CI 76.51 to 148.42 vs 65.45; 95% CI 58.01 to 73.84, p=0.009). This difference was primarily driven by an increase in late revascularisations in CTO patients (27 of 35 events). After multivariable adjustment, compared with individuals with normal coronaries, the presence of CTO conferred the highest risk for adverse cardiac events (14.54; 95% CI 9.11 to 23.20, p<0.001).Conclusions: The detection of CTO on non-invasive CCTA is associated with increased rate of late revascularisation but similar 2-year mortality as compared with moderate-to-severe CAD.Trial Registration Number: NCT01443637. [ABSTRACT FROM AUTHOR]

Published
2019
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115. Improved 5-year prediction of all-cause mortality by coronary CT angiography applying the CONFIRM score

Author

Deseive, Simon, primary, Shaw, Leslee J., additional, Min, James K., additional, Achenbach, Stephan, additional, Andreini, Daniele, additional, Al-Mallah, Mouaz H., additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Callister, Tracy Q., additional, Cademartiri, Filippo, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Cury, Ricardo C., additional, DeLago, Augustin, additional, Dunning, Allison M., additional, Feuchtner, Gudrun, additional, Kaufmann, Philipp A., additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, Marques, Hugo, additional, Maffei, Erica, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Rubinshtein, Ronin, additional, Villines, Todd C., additional, Hausleiter, Jörg, additional, and Hadamitzky, Martin, additional

Published
2016
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116. Impact of age and sex on left ventricular function determined by coronary computed tomographic angiography: results from the prospective multicentre CONFIRM study

Author

Gebhard, Catherine, primary, Buechel, Ronny R., additional, Stähli, Barbara E., additional, Gransar, Heidi, additional, Achenbach, Stephan, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Callister, Tracy Q., additional, Chow, Benjamin, additional, Dunning, Allison, additional, Al-Mallah, Mouaz H., additional, Cademartiri, Filippo, additional, Chinnaiyan, Kavitha, additional, Rubinshtein, Ronen, additional, Marques, Hugo, additional, DeLago, Augustin, additional, Villines, Todd C., additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Shaw, Leslee J., additional, Cury, Ricardo C., additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Maffei, Erica, additional, Raff, Gilbert, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, Chang, Hyuk-Jae, additional, Leipsic, Jonathon, additional, Min, James K., additional, and Kaufmann, Philipp A., additional

Published
2016
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117. Machine learning for prediction of all-cause mortality in patients with suspected coronary artery disease: a 5-year multicentre prospective registry analysis

Author

Motwani, Manish, primary, Dey, Damini, additional, Berman, Daniel S., additional, Germano, Guido, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz H., additional, Andreini, Daniele, additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Cury, Ricardo C., additional, Delago, Augustin, additional, Gomez, Millie, additional, Gransar, Heidi, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Hindoyan, Niree, additional, Feuchtner, Gudrun, additional, Kaufmann, Philipp A., additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, Lin, Fay Y., additional, Maffei, Erica, additional, Marques, Hugo, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Rubinshtein, Ronen, additional, Shaw, Leslee J., additional, Stehli, Julia, additional, Villines, Todd C., additional, Dunning, Allison, additional, Min, James K., additional, and Slomka, Piotr J., additional

Published
2016
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118. Absence of Coronary Artery Calcium Identifies Asymptomatic Diabetic Individuals at Low Near-Term But Not Long-Term Risk of Mortality

Author

Valenti, Valentina, primary, Hartaigh, Bríain ó, additional, Cho, Iksung, additional, Schulman-Marcus, Joshua, additional, Gransar, Heidi, additional, Heo, Ran, additional, Truong, Quynh A., additional, Shaw, Leslee J., additional, Knapper, Joseph, additional, Kelkar, Anita A., additional, Sciarretta, Sebastiano, additional, Chang, Hyuk-Jae, additional, Callister, Tracy Q., additional, and Min, James K., additional

Published
2016
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119. Coronary calcium scoring for long-term mortality prediction in patients with and without a family history of coronary disease

Author

Knapper, Joseph T, primary, Khosa, Faisal, additional, Blaha, Michael J, additional, Lebeis, Taylor A, additional, Kay, Jenna, additional, Sandesara, Pratik B, additional, Kelkar, Anita A, additional, Berman, Daniel S, additional, Quyyumi, Arshed A, additional, Budoff, Matthew J, additional, Min, James K, additional, Valenti, Valentina, additional, Giambrone, Ashley E, additional, Callister, Tracy Q, additional, and Shaw, Leslee J, additional

Published
2015
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120. Incremental prognostic value of coronary computed tomography angiography over coronary calciumscoring formajor adverse cardiac events in elderly asymptomatic individuals.

Author

Donghee Han, Hartaigh, Bríain Ó., Gransar, Heidi, Ji Hyun Lee, Rizvi, Asim, Baskaran, Lohendran, Schulman-Marcus, Joshua, Dunning, Allison, Achenbach, Stephan, Al-Mallah, Mouaz H., Berman, Daniel S., Budoff, Matthew J., Cademartiri, Filippo, Maffei, Erica, Callister, Tracy Q., Chinnaiyan, Kavitha, Chow, Benjamin J. W., DeLago, Augustin, Hadamitzky, Martin, and Hausleiter, Joerg

Subjects
CORONARY arterial radiography, AGE distribution, BLOOD vessels, CALCIUM, CARDIOVASCULAR diseases risk factors, COMPUTED tomography, CORONARY artery stenosis, CORONARY disease, MYOCARDIAL infarction, PROBABILITY theory, RISK assessment, SYMPTOMS, SEVERITY of illness index, PROGNOSIS
Abstract

Aims Coronary computed tomography angiography (CCTA) and coronary artery calcium score (CACS) have prognostic value for coronary artery disease (CAD) events beyond traditional risk assessment. Age is a risk factor with very high weight and little is known regarding the incremental value of CCTA over CAC for predicting cardiac events in older adults. Methods and results Of 27 125 individuals undergoing CCTA, a total of 3145 asymptomatic adults were identified. This study sample was categorized according to tertiles of age (cut-off points: 52 and 62 years). CAD severity was classified as 0, 1-49, and ≥50% maximal stenosis in CCTA, and further categorized according to number of vessels ≥50% stenosis. The Framingham 10-year risk score (FRS) and CACS were employed as major covariates. Major adverse cardiovascular events (MACE) were defined as a composite of all-cause death or non-fatal MI. During a median follow-up of 26 months (interquartile range: 18-41months), 59 (1.9%) MACE occurred. For patients in the top age tertile, CCTA improved discrimination beyond a model included FRS and CACS (C-statistic: 0.75 vs. 0.70, P-value= 0.015). Likewise, the addition of CCTA improved category-free net reclassification (cNRI) of MACE in patients within the highest age tertile (e.g. cNRI = 0.75; proportion of events/non-events reclassified were 50 and 25%, respectively; P-value <0.05, all). CCTA displayed no incremental benefit beyond FRS and CACS for prediction of MACE in the lower age tertiles. Conclusion CCTA provides added prognostic value beyond cardiac risk factors and CACS for the prediction of MACE in asymptomatic older adults. [ABSTRACT FROM AUTHOR]

Published
2018
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121. A Comparison of Mortality Rates in a Large Population of Smokers and Non-smokers: based on the Presence or Absence of Coronary Artery Calcification

Author

McEvoy, John W, Blaha, Michael J, Rivera, Juan J, Budoff, Matthew J, Khan, Atif N, Shaw, Leslee J, Berman, Daniel S, Raggi, Paolo, Min, James K, Rumberger, John A, Callister, Tracy Q, Blumenthal, Roger S., and Nasir, Khurram

Subjects
Adult, Male, Chi-Square Distribution, Time Factors, Smoking, Coronary Artery Disease, Kaplan-Meier Estimate, Middle Aged, Coronary Angiography, Risk Assessment, Severity of Illness Index, Article, United States, Risk Factors, Cause of Death, Multivariate Analysis, Humans, Female, Radionuclide Imaging, Tomography, X-Ray Computed, Vascular Calcification, Aged, Proportional Hazards Models
Abstract

The aim of this study was to further explore the interplay between smoking status, coronary artery calcium (CAC), and all-cause mortality.Prior studies have not directly compared the relative prognostic impact of CAC in smokers versus nonsmokers. In particular, although a calcium score of zero (CAC = 0) is a known favorable prognostic marker, whether smokers with CAC = 0 have as good a prognosis as nonsmokers with CAC = 0 is unknown. Given that computed tomography (CT) screening for lung cancer appears effective in smokers, the relative prognostic implications of visualizing any CAC versus no CAC on such screening also deserve study.Our study cohort consisted of 44,042 asymptomatic individuals referred for noncontrast cardiac CT (age 54 ± 11 years, 54% men). Subjects were followed for a mean of 5.6 years. The primary endpoint was all-cause mortality.Approximately 14% (n = 6,020) of subjects were active smokers at enrollment. There were 901 deaths (2.05%) overall, with increased mortality in smokers versus nonsmokers (4.3% vs. 1.7%, p0.0001). Smoking remained a risk factor for mortality across increasing strata of CAC scores (1 to 100, 101 to 400, and400). At each stratum of elevated CAC score, mortality in smokers was consistently higher than mortality in nonsmokers from the CAC stratum above. In multivariable analysis within these strata, we found mortality hazard ratios of 3.8 (95% confidence interval [CI]: 2.8 to 5.2), 3.5 (95% CI: 2.6 to 4.9), and 2.7 (95% CI: 2.1 to 3.5), respectively, in smokers compared with nonsmokers. However, among the 19,898 individuals with CAC = 0, the mortality hazard ratio for smokers without CAC was 3.6 (95% CI: 2.3 to 5.7), compared with nonsmokers without CAC.Smoking is a risk factor for death across the entire spectrum of subclinical coronary atherosclerosis. Smokers with any CAC had significantly higher mortality than smokers without CAC, a finding with implications for smokers undergoing lung cancer CT-based screening. However, the absence of CAC might not be as useful a "negative risk factor" in active smokers, because this group has mortality rates similar to nonsmokers with mild-to-moderate atherosclerosis.

Published
2012

122. Incremental prognostic value of cardiac computed tomography in coronary artery disease using CONFIRM: COroNary computed tomography angiography evaluation for clinical outcomes: an InteRnational Multicenter registry

Author

Chow Benjamin J W, Small Gary, Yam Yeung, Chen Li, Achenbach Stephan, Al-Mallah Mouaz, Berman Daniel S, Budoff Matthew J, Cademartiri Filippo, Callister Tracy Q, Chang Hyuk-Jae, Cheng Victor, Chinnaiyan Kavitha M, Delago Augustin, Dunning Allison, Hadamitzky Martin, Hausleiter Jörg, Kaufmann Philipp, Lin Fay, Maffei Erica, Raff Gilbert L, Shaw Leslee J, Villines Todd C, Min James K, CONFIRM Investigators, University of Zurich, and Chow, B J W

Subjects
Male, medicine.medical_specialty, Time Factors, 610 Medicine & health, Coronary Artery Disease, 030204 cardiovascular system & hematology, Coronary Angiography, Global Health, Risk Assessment, Severity of Illness Index, 2705 Cardiology and Cardiovascular Medicine, Coronary artery disease, 03 medical and health sciences, 0302 clinical medicine, Predictive Value of Tests, Internal medicine, Cause of Death, Severity of illness, 2741 Radiology, Nuclear Medicine and Imaging, Medicine, Humans, Radiology, Nuclear Medicine and imaging, cardiovascular diseases, 030212 general & internal medicine, Myocardial infarction, Prospective Studies, Registries, Proportional Hazards Models, Ejection fraction, business.industry, Incidence, Hazard ratio, 10181 Clinic for Nuclear Medicine, Middle Aged, medicine.disease, Prognosis, Confidence interval, 3. Good health, Transplantation, ROC Curve, Predictive value of tests, Cardiology, Female, Radiology, Cardiology and Cardiovascular Medicine, business, Tomography, X-Ray Computed, Follow-Up Studies
Abstract

Background— Large multicenter studies validating the prognostic value of coronary computed tomographic angiography (CCTA) and left ventricular ejection fraction (LVEF) are lacking. We sought to confirm the independent and incremental prognostic value of coronary artery disease (CAD) severity measured using 64-slice CCTA over LVEF and clinical variables. Methods and Results— A large international multicenter registry (CONFIRM Registry) was queried, and CCTA patients with LVEF data on CCTA were screened. Patients with a history of myocardial infarction, coronary revascularization, or cardiac transplantation were excluded. The National Cholesterol Education Program-Adult Treatment Panel III risk was calculated for each patient, and CCTA was evaluated for CAD severity (normal, nonobstructive, non–high-risk, or high-risk CAD) and LVEF Conclusions— Our results demonstrate that CCTA measures of CAD severity and LVEF have independent prognostic value. Incorporation of CAD severity provides incremental value for predicting all-cause death over routine clinical predictors and LVEF in patients with suspected obstructive CAD.

Published
2011

123. A 15-Year Warranty Period for Asymptomatic Individuals Without Coronary Artery Calcium

Author

Valenti, Valentina, primary, ó Hartaigh, Bríain, additional, Heo, Ran, additional, Cho, Iksung, additional, Schulman-Marcus, Joshua, additional, Gransar, Heidi, additional, Truong, Quynh A., additional, Shaw, Leslee J., additional, Knapper, Joseph, additional, Kelkar, Anita A., additional, Sandesara, Pratik, additional, Lin, Fay Y., additional, Sciarretta, Sebastiano, additional, Chang, Hyuk-Jae, additional, Callister, Tracy Q., additional, and Min, James K., additional

Published
2015
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124. Coronary dominance and prognosis in patients undergoing coronary computed tomographic angiography: results from the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) registry

Author

Gebhard, Catherine, primary, Fuchs, Tobias A., additional, Stehli, Julia, additional, Gransar, Heidi, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Andreini, Daniele, additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha M., additional, Chow, Benjamin J. W., additional, Cury, Ricardo C., additional, Delago, Augustin, additional, Gomez, Millie J., additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Hindoyan, Niree, additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, Lin, Fay Y., additional, Maffei, Erica, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Shaw, Leslee J., additional, Villines, Todd C., additional, Dunning, Allison M., additional, Min, James K., additional, and Kaufmann, Philipp A., additional

Published
2015
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125. Abstract 17557: Prevalence, Characteristics, and Early Treatment Strategies of Patients with Chronic Total Occlusions Undergoing Coronary Computed Tomography Angiography

Author

Opolski, Maksymilian P, primary, Hartaigh, Bríain Ó, additional, Gransar, Heidi, additional, Schulman-Marcus, Joshua, additional, Truong, Quynh A, additional, Berman, Daniel S, additional, Budoff, Matthew J, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Andreini, Daniele, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J, additional, Cury, Ricardo, additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Kaufmann, Philipp A, additional, Leipsic, Jonathon, additional, Lin, Fay Y, additional, Maffei, Erica, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Shaw, Leslee J, additional, Villines, Todd C, additional, Dunning, Allison, additional, and Min, James K, additional

Published
2014
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126. Abstract 12435: Coronary Artery Calcium Score of Zero Predicts Lower All-Cause Mortality Over a Long-Term Follow-Up

Author

Knapper, Joseph T, primary, Lebeis, Taylor, additional, Southmayd, Geoff, additional, Sandesara, Pratik, additional, Blaha, Michael J, additional, Berman, Daniel, additional, Quyyumi, Arshed, additional, Budoff, Michael J, additional, Min, James K, additional, Valenti, Valentina, additional, Callister, Tracy Q, additional, Giambrone, Ashley E, additional, and Shaw, Leslee J, additional

Published
2014
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127. Abstract 12044: Absence of Coronary Artery Disease by Coronary Computed Tomographic Angiography and the Warranty Period Associated With All-Cause Mortality: Findings From the CONFIRM Long-Term Follow-Up Registry

Author

Cho, Iksung, primary, ó Hartaigh, Bríain, additional, Gransar, Heidi, additional, Schulman-Marcus, Joshua, additional, Valenti, Valentina, additional, Berman, Daniel S, additional, Budoff, Matthew J, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Andreini, Daniele, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Cury, Ricardo, additional, Delago, Augustin, additional, Gomez, Millie, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Hindoyan, Niree, additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Kaufmann, Philipp A, additional, Leipsic, Jonathon, additional, Lin, Fay Y, additional, Maffei, Erica, additional, Pontone, Gianluca, additional, Raff, Gilbert, additional, Shaw, Leslee J, additional, Villines, Todd C, additional, Dunning, Allison, additional, and Min, James K, additional

Published
2014
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128. Abstract 15721: Coronary Artery Calcium Scoring Effectively Stratifies Long-Term Mortality Risk in Smokers and Non-Smokers

Author

Lebeis, Taylor A, primary, Sandesara, Pratik, additional, Knapper, Joseph, additional, Blaha, Michael J, additional, Berman, Daniel S, additional, Quyyumi, Arshed, additional, Budoff, Matthew J, additional, Min, James K, additional, Giambrone, Ashley E, additional, Callister, Tracy Q, additional, and Shaw, Leslee J, additional

Published
2014
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129. Incremental prognostic utility of coronary CT angiography for asymptomatic patients based upon extent and severity of coronary artery calcium: results from the COronary CT Angiography EvaluatioN For Clinical Outcomes InteRnational Multicenter (CONFIRM) Study

Author

Cho, Iksung, primary, Chang, Hyuk-Jae, additional, Ó Hartaigh, Bríain, additional, Shin, Sanghoon, additional, Sung, Ji Min, additional, Lin, Fay Y., additional, Achenbach, Stephan, additional, Heo, Ran, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Callister, Tracy Q., additional, Al-Mallah, Mouaz H., additional, Cademartiri, Filippo, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Dunning, Allison M., additional, DeLago, Augustin, additional, Villines, Todd C., additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Leipsic, Jonathon, additional, Shaw, Leslee J., additional, Kaufmann, Philipp A., additional, Cury, Ricardo C., additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Maffei, Erica, additional, Raff, Gilbert, additional, Pontone, Gianluca, additional, Andreini, Daniele, additional, and Min, James K., additional

Published
2014
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131. Reply

Author

Min, James K., Shaw, Leslee J., Devereux, Richard B., Okin, Peter M., Weinsaft, Jonathan W., Russo, Donald J., Lippolis, Nicholas J., Berman, Daniel S., and Callister, Tracy Q.

Subjects
Cardiology and Cardiovascular Medicine
Published
2008

132. Abstract 19498: Abnormal Left ventricular Volumes Identified by Computed Tomography Improves Risk Stratification and Discrimination of Patients At Risk of Increased Mortality: Results from 3706 Patients in the Prospective Multicenter International CONFIRM Study

Author

Arsanjani, Reza, primary, Labounty, Troy, additional, Cheng, Victor Y, additional, Lin, Fay Y, additional, Achenbach, Stephen, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew J, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J, additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp, additional, Shaw, Leslee J, additional, Villines, Todd C, additional, Berman, Daniel S, additional, and Min, James K, additional

Published
2012
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133. Abstract 18267: Coronary Risk Factors and Prevalence and Severity of Coronary Atherosclerosis in the Young

Author

Otaki, Yuka, primary, Gransar, Heidi, additional, Dey, Damini, additional, Lin, Fay, additional, Cheng, Victor, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Matthew, Budoff, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin, additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hauesleiter, Joerg, additional, Kaufmann, Philippo, additional, Maeffei, Erica, additional, Shaw, LesLee, additional, Berman, Daniel, additional, Feuchtner, Gurdun, additional, Dunning, Allison, additional, Villines, Todd, additional, and Min, James K, additional

Published
2012
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134. Statins use and coronary artery plaque composition: Results from the International Multicenter CONFIRM Registry

Author

Nakazato, Ryo, primary, Gransar, Heidi, additional, Berman, Daniel S., additional, Cheng, Victor Y., additional, Lin, Fay Y., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Cury, Ricardo C., additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp, additional, Maffei, Erica, additional, Raff, Gilbert, additional, Shaw, Leslee J., additional, Villines, Todd C., additional, Dunning, Allison, additional, Feuchtner, Gudrun, additional, Kim, Yong-Jin, additional, Leipsic, Jonathon, additional, and Min, James K., additional

Published
2012
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135. Coronary Computed Tomographic Angiography as a Gatekeeper to Invasive Diagnostic and Surgical Procedures

Author

Shaw, Leslee J., primary, Hausleiter, Jörg, additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Cademartiri, Fillippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Kim, Yong-Jin, additional, Cheng, Victor Y., additional, Chow, Benjamin J.W., additional, Cury, Ricardo C., additional, Delago, Augustin J., additional, Dunning, Allison L., additional, Feuchtner, Gudrun M., additional, Hadamitzky, Martin, additional, Karlsberg, Ronald P., additional, Kaufmann, Philipp A., additional, Leipsic, Jonathon, additional, Lin, Fay Y., additional, Chinnaiyan, Kavitha M., additional, Maffei, Erica, additional, Raff, Gilbert L., additional, Villines, Todd C., additional, LaBounty, Troy, additional, Gomez, Millie J., additional, and Min, James K., additional

Published
2012
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136. Mortality Rates in Smokers and Nonsmokers in the Presence or Absence of Coronary Artery Calcification

Author

McEvoy, John W., primary, Blaha, Michael J., additional, Rivera, Juan J., additional, Budoff, Matthew J., additional, Khan, Atif N., additional, Shaw, Leslee J., additional, Berman, Daniel S., additional, Raggi, Paolo, additional, Min, James K., additional, Rumberger, John A., additional, Callister, Tracy Q., additional, Blumenthal, Roger S., additional, and Nasir, Khurram, additional

Published
2012
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137. Coronary Computed Tomographic Angiography and Risk of All-Cause Mortality and Nonfatal Myocardial Infarction in Subjects Without Chest Pain Syndrome From the CONFIRM Registry (Coronary CT Angiography Evaluation for Clinical Outcomes: An International Multicenter Registry)

Author

Cho, Iksung, primary, Chang, Hyuk-Jae, additional, Sung, Ji Min, additional, Pencina, Michael J., additional, Lin, Fay Y., additional, Dunning, Allison M., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Callister, Tracy Q., additional, Chow, Benjamin J.W., additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Maffei, Erica, additional, Cademartiri, Filippo, additional, Kaufmann, Philipp, additional, Shaw, Leslee J., additional, Raff, Gil L., additional, Chinnaiyan, Kavitha M., additional, Villines, Todd C., additional, Cheng, Victor, additional, Nasir, Khurram, additional, Gomez, Millie, additional, and Min, James K., additional

Published
2012
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138. Reply

Author

Min, James K., primary, Dunning, Allison, additional, Lin, Fay Y., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Cheng, Victor, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Philipp, additional, Maffei, Erica, additional, Raff, Gilbert, additional, Shaw, Leslee J., additional, Villines, Todd, additional, and Berman, Daniel S., additional

Published
2012
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139. Performance of the Traditional Age, Sex, and Angina Typicality–Based Approach for Estimating Pretest Probability of Angiographically Significant Coronary Artery Disease in Patients Undergoing Coronary Computed Tomographic Angiography

Author

Cheng, Victor Y., primary, Berman, Daniel S., additional, Rozanski, Alan, additional, Dunning, Allison M., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha, additional, Chow, Benjamin J.W., additional, Delago, Augustin, additional, Gomez, Millie, additional, Hadamitzky, Martin, additional, Hausleiter, Jörg, additional, Karlsberg, Ronald P., additional, Kaufmann, Philipp, additional, Lin, Fay Y., additional, Maffei, Erica, additional, Raff, Gilbert L., additional, Villines, Todd C., additional, Shaw, Leslee J., additional, and Min, James K., additional

Published
2011
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140. Abstract 16715: Anatomical Data Defined by 64-Slice CT Angiography Predicts Prognosis of Coronary Artery by-Pass Patients More Accurately That Clinical Risk Predictors

Author

Small, Gary R, primary, Yam, Yeung, additional, Chen, Li, additional, Ahmed, Osman, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S, additional, Cheng, Victor Y, additional, Chinnaiyan, Kavitha, additional, Raff, Gilbert L, additional, Villines, Todd C, additional, Achenbach, Stephan, additional, Budoff, Matthew J, additional, Cademartiri, Filippo, additional, Callister, Tracy Q, additional, Chang, Hyuk-Jae, additional, Delago, Augustin, additional, Dunning, Allison, additional, Hadamitzky, Martin, additional, Hausleiter, Jörg, additional, Kaufmann, Philipp, additional, Lin, Fay Y, additional, Maffei, Erica, additional, Min, James K, additional, Shaw, Leslee J, additional, and Chow, Benjamin J, additional

Published
2011
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141. Prognostic Assessment of Coronary Artery Bypass Patients With 64-Slice Computed Tomography Angiography

Author

Small, Gary R., primary, Yam, Yeung, additional, Chen, Li, additional, Ahmed, Osman, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Cheng, Victor Y., additional, Chinnaiyan, Kavitha, additional, Raff, Gilbert, additional, Villines, Todd C., additional, Achenbach, Stephan, additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Delago, Augustin, additional, Dunning, Allison, additional, Hadamitzky, Martin, additional, Hausleiter, Jorg, additional, Kaufmann, Philipp, additional, Lin, Fay, additional, Maffei, Erica, additional, Min, James K., additional, Shaw, Leslee J., additional, and Chow, Benjamin J.W., additional

Published
2011
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143. CIGARETTE SMOKING, PROXIMAL CORONARY ARTERIAL PLAQUE COMPOSITION, AN RISK OF MYOCARDIAL INFARCTION AND DEATH: A STUDY OF NONDIABETIC MEN AND WOMEN IN THE MULTINATIONAL CONFIRM REGISTRY (CORONARY CT ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER REGISTRY)

Author

Cheng, Victor, primary, Berman, Daniel S., additional, Dunning, Allison L., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Chinnaiyan, Kavitha M., additional, Chow, Benjamin J.W., additional, Delago, Augustin J., additional, Hadamitzky, Martin, additional, Hausleiter, Joerg, additional, Kaufmann, Phillipp, additional, Lin, Fay Y., additional, Nasir, Khurram, additional, Raff, Gil, additional, Shaw, Leslee J., additional, Villines, Todd C., additional, and Min, James K., additional

Published
2011
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144. RELATIONSHIP OF NON-OBSTRUCTIVE CORONARY ARTERY DISEASE TO MORTALITY: RESULTS FROM 18,037 PATIENTS WITH <50% STENOSIS IN THE CONFIRM REGISTRY (CORONARY CT ANGIOGRAPHY EVALUATION FOR CLINICAL OUTCOMES: AN INTERNATIONAL MULTICENTER REGISTRY)

Author

Min, James K., primary, Dunning, Allison M., additional, Lin, Fay Y., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Cheng, Victor, additional, Chow, Benjamin JW, additional, Delago, Augustin, additional, Hadamitzsky, Martin, additional, Hausleiter, Joerg, additional, Kaufman, Philipp, additional, Nasir, Khurram, additional, Pencina, Michael, additional, and Shaw, Leslee J., additional

Published
2011
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145. INCREASING CORONARY ARTERY CALCIUM IS ASSOCIATED WITH INCREASED ALL-CAUSE MORTALITY AMONG ASYMPTOMATIC INDIVIDUALS WITH A FAMILY HISTORY OF CORONARY HEART DISEASE

Author

Ketlogetswe, Kerunne, primary, Blaha, Michael J., additional, Budoff, Matthew J., additional, Khan, Atif N., additional, Rivera, Juan J., additional, Shaw, Leslee J., additional, Berman, Daniel S., additional, Raggi, Paolo, additional, Min, James K., additional, Callister, Tracy Q., additional, Rumberger, John A., additional, Blumenthal, Roger S., additional, and Nasir, Khurram, additional

Published
2011
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146. GENDER DIFFERENCES IN ALL-CAUSE DEATH BY EXTENT AND SEVERITY OF CORONARY ARTERY DISEASE BY CARDIAC COMPUTED TOMOGRAPHIC ANGIOGRAPHY: A MATCHED ANALYSIS OF THE CONFIRM REGISTRY

Author

Lin, Fay, primary, Chinnaiyan, Kavitha, additional, Dunning, Allison M., additional, Shaw, Leslee J., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz, additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Chow, Benjamin J.W., additional, Delago, Augustin J., additional, Hausleiter, Joerg, additional, Hadamitzky, Martin, additional, Kaufmann, Philipp, additional, Raff, Gilbert L., additional, Villines, Todd, additional, and Min, James K., additional

Published
2011
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147. Rationale and design of the CONFIRM (COronary CT Angiography EvaluatioN For Clinical Outcomes: An InteRnational Multicenter) Registry

Author

Min, James K., primary, Dunning, Allison, additional, Lin, Fay Y., additional, Achenbach, Stephan, additional, Al-Mallah, Mouaz H., additional, Berman, Daniel S., additional, Budoff, Matthew J., additional, Cademartiri, Filippo, additional, Callister, Tracy Q., additional, Chang, Hyuk-Jae, additional, Cheng, Victor, additional, Chinnaiyan, Kavitha M., additional, Chow, Benjamin, additional, Delago, Augustin, additional, Hadamitzky, Martin, additional, Hausleiter, Jorg, additional, Karlsberg, Ronald P., additional, Kaufmann, Philipp, additional, Maffei, Erica, additional, Nasir, Khurram, additional, Pencina, Michael J., additional, Raff, Gilbert L., additional, Shaw, Leslee J., additional, and Villines, Todd C., additional

Published
2011
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148. Reply

Author

Min, James K., primary, Dunning, Allison, additional, Shaw, Leslee J., additional, Berman, Daniel S., additional, and Callister, Tracy Q., additional

Published
2010
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150. NEAR-TERM POST-TEST TREATMENT, FUNCTIONAL STATUS AND RESOURCE UTILIZATION IN INTERMEDIATE RISK INDIVIDUALS WITH STABLE CHEST PAIN SYNDROME UNDERGOING 64-DETECTOR ROW CORONARY COMPUTED TOMOGRAPHIC ANGIOGRAPHY VERSUS MYOCARDIAL PERFUSION SPECT: A PROSPECTIVE MULTICENTER RANDOMIZED TRIAL

Author

Lin, Fay, primary, Koduru, Sunaina, additional, Cole, Jason H., additional, Hines, Jerome L., additional, Labounty, Troy M., additional, Weinsaft, Jonathan W., additional, Callister, Tracy Q., additional, Shaw, Leslee J., additional, Berman, Daniel S., additional, and Min, James K., additional

Published
2010
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