Search

Objectives: The study of comprehensive satisfaction with healthcare is still limited due to nonstandard measurement tools of patient satisfaction for the Chinese population. Therefore, the present study aimed to verify the validity, reliability, and measurement invariance of the revised Patient Satisfaction Questionnaire (PSQ-R) and conducted network analysis among a sample of the Chinese population. Methods: A cross-sectional study using telephone surveys was conducted from April 2022 to August 2022. A total of 1377 participants who had been hospitalized completed the survey (481 males [34.9%], mean age = 49.4 years [SD ± 19.0]). Results: Four factors ('satisfaction with medical staff', 'satisfaction with hospital', 'satisfaction with medical costs', and 'satisfaction with medical insurance premiums'), were verified through confirmatory factor analysis (CFA) and had good equivalence across genders. The 'satisfaction with medical staff' and 'satisfaction with hospital' factors had the strongest edge intensity in the factor-level network. Conclusions: The 18-item (four-factor) PSQ-R has good validity, reliability, and measurement invariance. The four dimensions appear to describe patient satisfaction well among the Chinese population who had been hospitalized. To effectively enhance patient satisfaction, the quality of healthcare service and medical staff skills should both be improved, medical insurance premiums should be increased, and medical costs should be decreased. [ABSTRACT FROM AUTHOR]

AbstractObjectiveMethodResultsConclusions\nHIGHLIGHTSPoor sleep quality exacerbates suicidal ideation. Depression, anxiety, and stress may play important roles in this relationship. However, the underlying mechanisms remain unknown.A total of 2,598 young men were recruited for a cross-sectional study focusing on a range of sociodemographic factors, emotions, sleep quality, and suicidal ideation. Parallel, serial, and moderated mediation models were used to determine whether depression, anxiety, and stress mediated the relationship between poor sleep quality and suicidal ideation.Direct and indirect effects of poor sleep quality on suicidal ideation were observed. Depression, anxiety, and stress mediated the relationship between poor sleep quality and suicidal ideation (βDepression = 0.166, 95% confidence interval [CI]: 0.144, 0191; βAnxiety = 0.153, 95% CI: 0.130, 0.177; βStress = 0.176, 95% CI: 0.154, 0.200). The serial mediation model indicated that depressive and stress symptoms co-play a serial mediating role in the relationship between poor sleep quality and suicidal ideation (βa = 0.049, 95% CI: 0.036, 0.062; βb = 0.099, 95% CI: 0.080, 0.120). The moderated mediation model revealed that the mediating role of stress on the relationship between poor sleep quality and suicidal ideation was moderated by depression (β = 0.173, 95% CI: 0.150, 0.197). Self-reported measures and the study’s cross-sectional design preclude the causal inferences reported.The findings of this study prompt clinical and scientific researchers to consider the interplay among affective disorders when investigating etiological and psychological factors that may contribute to suicidal ideation.Poor sleep quality is associated with increased levels of suicidal ideation.Sleep disturbances are among the well-known risk factors for suicidal ideation.Poor sleep quality impairs critical processes involved in affective functioning. [ABSTRACT FROM AUTHOR]

[Display omitted] Exposure to polycyclic aromatic hydrocarbons (PAHs) in the Chinese population was among the highest globally and associated with various adverse effects. This study examines the impact of China's two-phase clean air initiatives, namely the Air Pollution Prevention and Control Action Plan (APPCAP) in 2013–2017 and the Blue-Sky Defense War (BSDW) in 2018–2020, on PAH levels and human exposures in Beijing. To evaluate the effects of APPCAP, we measured 16 PAHs in 287 PM 2.5 samples collected in Beijing and 9 PAH metabolites in 358 urine samples obtained from 54 individuals who traveled from Los Angeles to Beijing between 2014 and 2018. The concentration of PM 2.5 -bound benzo[a]pyrene equivalents (BaPeq) decreased by 88.5% in 2014–2018 due to reduced traffic, coal, and biomass emissions. PAH metabolite concentrations in travelers' urine decreased by 52.3% in Beijing, correlated with changes in PM 2.5 and NO 2 levels. In contrast, no significant changes were observed in Los Angeles. To evaluate BSDW's effects, we collected 123 additional PM 2.5 samples for PAH measurements in 2019–2021. We observed sustained reductions in BaPeq concentrations attributable to reductions in coal and biomass emissions during the BSDW phase, but those from traffic sources remained unchanged. After accounting for meteorological factors, China's two-phase clean air initiatives jointly reduced Beijing's PM 2.5 -bound BaPeq concentrations by 96.6% from 2014 to 2021. These findings provide compelling evidence for the effectiveness of China's clean air actions in mitigating population exposure to PAHs in Beijing. [ABSTRACT FROM AUTHOR]

In recent decades, the concept of "Physical Literacy" has emerged as a significant breakthrough in enhancing the physical health of children and adolescents. This concept has become the guiding principle and future direction for physical education reform in Western countries. As China's economic and social development enters a new phase, the negative impact of insufficient physical activity on adolescent health remains a significant challenge to the strategies of "Healthy China" and "A Leading Sports Nation." The unique value of physical literacy, which emphasizes the importance of regular physical activity, aligns perfectly with the developmental needs of the nation, the era, and individuals. Given the crucial role of interpersonal support in the development of adolescents' physical literacy, this study employs questionnaire surveys and statistical analysis to investigate the current state of physical literacy among Chinese adolescents. It explores the predictive relationship between parental support, teacher support, and peer support on physical literacy, aiming to provide guidance for the future development of adolescents' physical literacy. The research findings indicate significant differences in the five dimensions of physical literacy (attitude, sports knowledge, emotion, athletic ability, and physical fitness) among adolescents of different grades and residence type. Additionally, there are notable gender differences in the dimensions of sports knowledge, emotion, and athletic ability. The interaction effect of gender and grade is particularly evident in the emotional and physical fitness dimensions. There is a significant correlation between interpersonal support and all dimensions of physical literacy. After controlling for variables such as gender, grade, and family background, interpersonal support for adolescent physical exercise was found to have a significant impact on all dimensions of physical literacy. Among the forms of support, peer support was identified as a more powerful predictor of physical literacy compared to parental and teacher support. [ABSTRACT FROM AUTHOR]

Problem: Significant differences exist between the body dimensions of Chinese and Western individuals, and these differences affect the injury characteristics of passengers in traffic accidents. Most current parametric finite element human models are based on Western body data, which does not adequately assess the injury risks for Chinese individuals. Therefore, it is imperative to establish a digital model that reflects the anatomical features of Chinese humans. This requires comprehensive anthropometric data specific to the Chinese population. Aim: This study aims to collect and analyze skeletal geometric parameters from various representative regions in China across different age groups to fill the gap in Chinese anthropometric data. Additionally, it seeks to explore regional and age-related differences in these parameters, providing a scientific basis for developing finite element models that reflect the characteristics of the Chinese population. Methods: Clinical CT data of skeletal geometric parameters were collected from 224 individuals across seven representative regions of China, including parameters of the head, chest, and lower limbs. Descriptive statistics, K-W tests, and U-tests were used to analyze regional differences. Spearman correlation and linear regression analyses were employed to assess the impact of age. Furthermore, weighted averages and weighted variances of skeletal geometric parameters were calculated to reflect the characteristics of individuals from various regions across the country, which will be applied in the development of Chinese human models. Results: The results indicate significant regional differences in the skeletal geometric parameters of Chinese individuals, exhibiting regional patterns between the north–south and east–west areas. While skeletal geometric parameters showed significant differences with age, no clear statistical pattern was observed. Conclusion: This study systematically extracts and analyzes the skeletal geometric parameters of the Chinese population from regional and age perspectives for the first time. These data will be applied in the development of Chinese human models, providing crucial support for improving passenger safety in traffic accidents, enhancing vehicle safety design, and establishing anthropometric standards suitable for the Chinese context. [ABSTRACT FROM AUTHOR]

Intertemporal decisions are crucial to survival, especially when humans are exposed to ecological threats. However, it remains unclear whether and how pandemic threats impact intertemporal choices across cultures. We conducted two studies in two cultural contexts (N = 1180). Study 1a found that Chinese who perceived more pandemic threats showed higher temporal discounting rates (i.e., preferred immediate smaller over delayed larger rewards), and this relationship was mediated by negative emotions. Study 1b, using threat priming, revealed that Chinese participants primed with a high-threat condition (depicting a pandemic threat) showed higher temporal discounting rates compared to those primed with a low-threat condition (describing the flu). Differently, Study 2a revealed that perceived pandemic threat levels of Americans did not directly predict temporal discounting rates. Using similar threat priming, Study 2b further confirmed that Americans in the high-threat priming condition showed no significant differences in temporal discounting rates compared to those in the low-threat priming condition. The current research deepens the understanding of the cultural difference in the impact of pandemic threats on intertemporal decision-making and further informs the development of interventions that promote individual future-oriented thinking in the face of pandemics. [ABSTRACT FROM AUTHOR]

Consumption is crucial to individual well-being and national economic development. This study investigates whether high-speed rail (HSR) influences consumption expenditure (CE) and consumption structure (CS) of urban and rural Chinese citizens. Using panel data from 2003 to 2019 and econometric models, this study finds that: (1) HSR significantly increases CE for both urban and rural residents, promotes CS upgrades in rural areas, but inhibits CS upgrades in urban areas. These results remain robust after extensive testing. (2) HSR's impact on urban consumption is relatively focused and singular, whereas its effect on rural consumption is dispersed and extensive. Additionally, the impact of HSR on consumption exhibited significant delays and regional characteristics. (3) Mediation analysis reveals that HSR significantly enhances urban and rural CE and facilitates rural CS upgrades through market, price, and income effects. However, it also triggers housing price increases, impeding urban CS upgrades. This study provides important references for the government to optimize transportation infrastructure investments, promote balanced economic development between urban and rural areas, and enhance residents' well-being. [ABSTRACT FROM AUTHOR]

Background: To identify the normal range and distribution in the cephalic index(CI) and horizontal point of maximum width(H-PMW) of Chinese children with normal brain development. Methods: We retrospectively analyzed Chinese Han children who visited our hospitals between June 2015 and June 2020 because of headache or suspected head injuries. 456 children (257 males, 199 females; aged 0–15 years) were enrolled and divided into 7 groups by age. The values of CI and H-PMW were measured using thin-slice brain computed tomography images. Results: The overall mean CI was 86.6 ± 5.2. The mean CI for males was 87.0 ± 5.1, and that for females was 86.0 ± 5.2. The overall mean H-PMW was 53.7 ± 2.4. The mean H-PMW for males was 53.8 ± 2.5, and that for females was 53.5 ± 2.3. The averages CI reached the maximum (89.98) at the age of 4–6 months, then began to decrease, decreased to the minimum (84.31) at the age of 2–3 years, and then gradually increased, and reached 86.17 at the age of 8–15 years. The average H-PMW was the smallest (52.17) at the age of 4–6 months, and reached 54.88 at the age of 8–15 years. Conclusion: The CI and H-PMW values of Chinese normal children reported in this study will provide a valuable reference to diagnose cranial deformities, assess the severity of the disease and the effectiveness of the treatment. [ABSTRACT FROM AUTHOR]

Previous environmental research used a general conceptualization of moral norms (e.g., it is my moral obligation to recycle) without specifying the exact moral underpinning of such a conceptualization. This analysis examined how five basic moral foundations (i.e., harm, fairness, ingroup loyalty, authority, and purity) were associated with Chinese residents' waste-sorting attitudes and intentions. This analysis used data from a cross-sectional online survey of 459 Chinese residents conducted in 2021. The results revealed that value-expressive attitudes were a fairly strong predictor of waste-sorting intentions, whereas attitudes about inconvenience and time were a weak predictor. Further analysis of direct and total relationships revealed that the moral foundations of ingroup loyalty and authority were the primary moral foundations for the Chinese participants; the effects were both direct and mediated by the value-expressive attitudes. Using detailed attitudinal and moral foundations can provide explanatory adequacy and specificity for environmental research and education efforts. Article Highlights: Value-expressive attitudes predicted Chinese participants' waste-sorting intentions Ingroup loyalty and authority were the primary moral values underlying Chinese waste-sorting intentions. The role of moral foundations/values and specific attitudes can vary by country and culture. [ABSTRACT FROM AUTHOR]

During adolescence, academics occupy a significant portion of time, and social needs reach their peak. It is crucial to explore two key challenges faced by adolescents: deviant peer affiliation and academic burnout. According to Self-Verification Theory, adolescents tend to select information that is consistent with their self-concept. This study aims to investigate the interrelationships among adolescents' core self-evaluation, academic burnout, and deviant peer affiliation. 1214 Chinese adolescents (Mage = 15.46, SDage = 0.71) from central China completed a questionnaire survey on Academic Burnout Inventory, Core Self-evaluation Scale, and Deviant Peer Affiliation Questionnaire. The findings revealed that deviant peer affiliation positively predicted academic burnout, while the reverse was not observed. Core self-evaluation was found to be predictors of both academic burnout and deviant peer affiliation, and in turn, core self-evaluation was influenced by the two factors. In addition, a dynamic cyclical relationship was found between core self-evaluation and academic burnout, and the mutual relations between academic burnout and deviant peer affiliation were through core self-evaluation. This research enhanced our comprehension of adolescents' self-evaluation, academic challenges, and peer interactions, highlighted the need to focus on the enduring influence of core self-evaluation on adolescents. [ABSTRACT FROM AUTHOR]

Background: An increasing number of studies have turned their lens to the application of Artificial Intelligence (AI) in the diagnosis and treatment of colorectal cancer (CRC). Objective: To clarify and visualize the basic situation, research hotspots, and development trends of AI in the diagnosis and treatment of CRC, and provide clues for research in the future. Methods: On January 31, 2024, the Web of Science Core Collection (WoSCC) database was searched to screen and export the relevant research published during 2004-2023, and Cite Space, VoSviewer, Bibliometrix were used to visualize the number of publications, countries (regions), institutions, journals, authors, citations, keywords, etc. Results: A total of 2715 pieces of literature were included. The number of publications grew slowly until the end of 2016, but rapidly after 2017, till to the peak of 798 in 2023. A total of 92 countries, 3997 organizations, and 15,667 authors were involved in this research. Chinese scholars released the highest number of publications, and the U.S. contributed the highest number of total citations. As to authors, MORI, YUICHI had the highest number of publications, and WANG, PU had the highest number of total citations. According to the analysis of citations and keywords, the current research hotspots aremainly related to "Colonoscopy", "Polyp Segmentation", "Digital Pathology", "Radiomics", "prognosis". Conclusion: Research on the application of AI in the diagnosis and treatment of CRC has made significant progress and is flourishing across the world. Current research hotspots include AI-assisted early screening and diagnosis, pathology, and staging, and prognosis assessment, and future research is predicted to put weight on multimodal data fusion, personalized treatment, and drug development. [ABSTRACT FROM AUTHOR]

Introduction: This retrospective study was conducted to assess the survival rates and prognostic factors in children with relapsed acute lymphoblastic leukemia (ALL) who were treated according to the Chinese Children's Cancer Group ALL-2015 protocol at the Children's Hospital of Chongqing Medical University. Methods: The study cohort involving 852 evaluable children with ALL reported a total of 146 relapses during a median follow-up period of 53 months. The primary outcomes measured were the second complete remission (CR2) rates, and 5-year event-free survival (EFS) and overall survival (OS) for patients who received re-treatment post-relapse. Patient data were stratified by ALL subtype (B-ALL vs. T-ALL), age at relapse, site of relapse, and timing of relapse. Univariate and multivariate analyses were performed to identify factors significantly associated with EFS and OS. Results: As of March 31, 2023, 146 relapses were observed, including 128 B-ALL and 18 T-ALL cases. The 8-year CIR was (19.8 ± 1.6)%, with no significant difference between B-ALL and T-ALL (P=0.271). Among the 105 patients who underwent re-treatment, 70 achieved CR2, resulting in a CR2 rate of 67.6%. The 5-year EFS and OS rates for re-treated patients were (45.0 ± 5.4)% and (56.9 ± 5.2)%, respectively. Significant differences in 5-year OS and EFS were found between B-ALL and T-ALL relapses (P < 0.001). The 5-year EFS and OS varied significantly with relapse timing and site of relapse. Factors significantly affecting EFS after relapse included the site of relapse, immunophenotyping, CR2 achievement, and hematopoietic stem cell transplantation (HSCT). Immunophenotyping, CR2 achievement, and HSCT were also identified as significant factors affecting OS after relapse. Discussion: Despite treatment with the CCCG-ALL-2015 protocol, a significant relapse rate was observed, with 72% of children opting for re-treatment post-relapse. The study highlights the importance of considering specific prognostic factors to inform tailored treatment strategies for relapsed childhood ALL. The findings emphasize the need for further research into improving therapeutic approaches for this patient population. This retrospective study was conducted to assess the survival rates and prognostic factors in children with relapsed acute lymphoblastic leukemia (ALL) who were treated according to the Chinese Children's Cancer Group ALL-2015 protocol at the Children's Hospital of Chongqing Medical University. [ABSTRACT FROM AUTHOR]

With the burgeoning research on positive psychology, grit has gradually attracted scholarly attention in the field of L2 acquisition, and it has been shown to be a significant positive predictor of L2 achievements and outcomes. However, despite being an important factor in L2 acquisition, grit has rarely been incorporated as a research variable in prior research on willingness to communicate in a second language (L2 WTC), especially among Chinese teenagers who find themselves in a foundational stage of developing their L2 communicative competence. Based on a survey among 238 Chinese junior high school students, this study analyzed the effect of their grit on their L2 WTC, and explored the differential roles of foreign language enjoyment (FLE) and anxiety (FLA) in their interactions. The results revealed that: (1) perseverance of effort (PE), consistency of interest (CI) and FLE had significantly positive correlations with L2 WTC, whereas FLA was found to have a significantly negative correlation with L2 WTC; (2) PE and CI served as significant positive predictors of L2 WTC; (3) FLE mediated the interactions between PE and L2 WTC and between CI and L2 WTC, while the mediating effects of FLA were found to be statistically non-significant. The findings can provide theoretical implications for furthering L2 WTC research, as well as practical reference for its development among Chinese junior high school students. [ABSTRACT FROM AUTHOR]

Background: SARC-F questionnaire is a simple and convenient tool for sarcopenia screening, and SARC-CalF is a modified version of it. The developments of their Chinese versions are warranted for the clinical use for Chinese population. This study aimed to culturally adapt the SARC-F questionnaire into Chinese using standardized methods, validate the reliability and diagnostic accuracy of the Chinese version SARC-F and SARC-CalF against five sarcopenia diagnosis criteria, and determine optimal cut-off values for clinical practice in Chinese population. Methods: The translation and cross-cultural adaptation of SARC-F into Chinese were conducted following the methodological report from European Union Geriatric Medicine Society Sarcopenia Special Interest Group. The Chinese version of SARC-F was validated through a diagnostic test, using diagnostic criteria of sarcopenia recommended by the revised 2019 European Working Group on Sarcopenia in Older People (EWGSOP2) consensus, Asian Working Group for Sarcopenia (AWGS2019) consensus, the International Working Group on Sarcopenia (IWGS), the Foundation for the National Institutes of Health (FNIH) Biomarkers Consortium and the Sarcopenia Definition and Outcomes Consortium (SDOC). Additional analysis was done against the criteria of severe sarcopenia according to the revised EWGSOP2 and AWGS2019. Results: The Chinese version of SARC-F was well translated and demonstrated good reliability and acceptability. The diagnostic test included 1859 community-dwelling older individuals from two medical centers. Against five different definitions of sarcopenia, the Chinese version of SARC-F showed reasonable diagnostic accuracy for sarcopenia screening (AUC 0.614–0.821), and was demonstrated low sensitivity (13.7–37.9%) but high specificity (94.8–97.7%) with a cut-off value of ≥ 4. SARC-CalF significantly enhanced the diagnostic accuracy of SARC-F when using definitions of EWGSOP2, AWGS2019 and IWGS (all P ≤ 0.001). A score of ≥ 2 for SARC-F and ≥ 7 for SARC-CalF were established as optimal cut-off points for identifying older individuals as at risk of sarcopenia in Chinese population. Conclusions: The Chinese version SARC-F is of reasonable reliability and validity for sarcopenia screening. Despite its low sensitivity, it proves to be a useful tool to identify severe cases in community taking advantage of its simplicity. SARC-CalF appears to be a more suitable screening tool for clinical use in detecting sarcopenia. [ABSTRACT FROM AUTHOR]

Mutation of methylenetetrahydrofolate reductase (MTHFR) C677T leads to the decrease of folate utilization and the impairment of spermatogenesis. This study attempts to investigate the association between MTHFR C677T polymorphisms and nonobstructive oligozoospermia, asthenozoospermia or oligoasthenozoospermia in the Chinese population. The study cohort comprised 189 patients diagnosed with oligozoospermia, asthenozoospermia or oligoasthenozoospermia, and 626 controls based on clinical examinations. The MTHFR c.677 genotype of all subjects was determined by fluorescence staining in situ hybridization and the significance of different genotype frequencies was further analyzed by Chi-square test. The results showed that the frequency of MTHFR 677 CT genotype in the oligozoospermia, asthenozoospermia and oligoasthenozoospermia group was 33.3%, 38.3% and 44.0% respectively, whereas it was 47.3% in the control group. The P value of Chi-square test was 0.070, 0.103 and 0.654, respectively. The frequency of MTHFR 677 TT genotype in the oligozoospermia, asthenozoospermia and oligoasthenozoospermia group was 31.1%, 11.7% and 18.0% respectively, while that in the control group was 19.5%. The P value of Chi-square test was 0.061, 0.070 and 0.066, respectively. Collectively, there is a weak association between MTHFR C677T polymorphisms and oligozoospermia, asthenozoospermia or oligoasthenozoospermia within the current Chinese population cohort. [ABSTRACT FROM AUTHOR]

This study aimed to explore the potential association between Endothelin type A receptor (EDNRA) genetic polymorphisms and susceptibility to large artery atherosclerotic stroke (LAA), as well as the involvement of inflammation mechanisms. We recruited Han Chinese patients with LAA and age- and sex-matched controls. The distribution of alleles and genotypes for 16 single nucleotide polymorphisms (SNPs) in EDNRA was analyzed using dominant, recessive, and co-dominant genetic models between cases and controls. We quantified the mRNA and protein levels of EDNRA and NLRP3 genes, and concentrations of inflammatory factors (TNFα, IL-1β, IL-6, IL-8, IL-10, IL-18, and CCL18) in peripheral blood samples randomly selected from cases and controls. We also investigated the relationship between these SNPs, gene expression patterns and inflammatory factor levels. A total of 428 LAA cases and 434 controls were enrolled in this study. The results showed that rs5343 TT genotype of EDNRA was significantly associated with an increased risk of LAA (OR = 3.243, 95%CI = 1.608–6.542, P = 0.001). It also demonstrated a significant upregulation level of NLRP3 as well as higher concentrations of IL-10, IL-18, and CCL-18 in cases compared to controls. Besides, we discovered that the EDNRA polymorphisms were linked to NLRP3, IL-6, IL-10, and IL-18 levels in cases. There existed a positive correlation between EDNRA transcription levels and both NLRP3 transcript levels (r = 0.437, p < 0.001) and IL-18 concentrations (r = 0.212, p < 0.001). EDNRA is linked to susceptibility of LAA. This association may be attributed to the NLRP3-mediated inflammatory pathway. [ABSTRACT FROM AUTHOR]

Purpose: This study aimed to investigate the real-world use and clinical outcomes of tixagevimab/cilgavimab in China during the Omicron outbreak in late 2022. Methods: This observational, real-world study included patients who received tixagevimab/cilgavimab from July 9 to December 30, 2022, in Hainan, China. Here, we report the baseline and characteristics and interim analysis results of the clinical outcomes in those receiving at least one dose of tixagevimab/cilgavimab (300 mg) for pre-exposure prophylaxis. Results: Among 248 subjects who received tixagevimab/cilgavimab, 229 subjects were included in this analysis. Until March 28, 2023, the median follow-up was 95 days. The mean age of the subjects was 44.4 ± 15.9 years, 11.8% were ≥ 65 years, and 41.5% were male. Fifty-eight (25.3%) subjects had comorbidities, 16.2% subjects had key immune compromised conditions. Seventy-two (32.6%) patients had laboratory-confirmed SARS-CoV-2 infection and/or received healthcare within three months; 71/72 (98.6%) had mild disease, and one (1.4%) was moderate. No COVID-19-related intensive care unit (ICU) admissions, extracorporeal membrane oxygenation utilizations, or death occurred. Two (0.9%) patients required hospitalization. One (0.4%) serious adverse event occurred, which was considered unrelated to tixagevimab/cilgavimab. Conclusion: Among Chinese patients receiving prophylactic tixagevimab/cilgavimab, the incidence of COVID-19-related hospitalization, ICU admission, or death was low during the Omicron surge. Further randomized controlled trials with larger sample sizes are needed to determine the effectiveness of tixagevimab/cilgavimab in preventing severe COVID-19 outcomes. Trial registration: The study was registered with clinicaltrial.gov (NCT05917951). [ABSTRACT FROM AUTHOR]

Background: The Mediterranean diet (MD) has shown promising results in preventing type 2 diabetes, particularly in Mediterranean and European populations. However, the applicability of these benefits to non-Mediterranean populations is unclear, with contradictory findings in the literature. Methods: In this study, we included 12,575 participants without diabetes at baseline from the China Health and Nutrition Survey (CHNS). Dietary intake was measured by three consecutive 24-h dietary recalls. The Mediterranean diet adherence (MDA) was measured by a score scale that included nine components of vegetables, legumes, fruits, nuts, cereals, fish, red meat, dairy products, and alcohol. New-onset diabetes was defined as self-reported physician-diagnosed diabetes during the follow-up. Results: During a median follow-up of 9.0 years, 445 (3.5%) subjects developed diabetes. Overall, there was an inverse association between the MDA score and new-onset diabetes (per score increment, HR 0.83, 95% CI 0.76–0.90). Moreover, age, sex, BMI, and energy intake significantly modified the association between the MDA score and the risk of new-onset diabetes (all P interactions < 0.05). Greater fruit, fish, and nut intake was significantly associated with a lower risk of new-onset diabetes. Conclusion: There was an inverse association between Mediterranean diet adherence and new-onset diabetes in the Chinese population. [ABSTRACT FROM AUTHOR]

Background: It is common knowledge that people's intestinal microbiota is significantly influenced by the external environment. Although the Antarctic continent has been discovered for nearly 200 years, it is still unclear how this environment affects the human intestinal microbiota, especially that of the Chinese Han population. Methods: Twelve explorers underwent a one-year Antarctic deployment from December 2017 to December 2018. The gut microbiota and clinical indexes at five time points, including two months (T1), five months (T2), eight months (T3), 11 months (T4) of residence in Antarctica and 7 months after returning to China (T5), were investigated. Results: The intestinal microbiota of the participants was changed after one-year Antarctic deployment even after they left Antarctica. For the microbiota tested after returning to China (T5), the amount of Citrobacter, Akkermansia and conditional pathogens such as Escherichia-Shigella increased significantly (P < 0.05). The concentration of the major biochemical indicators in the serum exhibited an increasing trend before T3, and decreased significantly at T4. When tested again at T5, most of the serum concentrations increased, only 5-hydroxytryptamine was significantly decreased. Spearman correlation analysis showed the change in the relative abundance of Anaerotruncus was negatively associated with the changes in the concentration of total thyroxine, alanine transaminase, γ-glutamyl transpeptidase, serum cystatin C and apolipoprotein A1. The relative abundance change in Citrobacter was positively associated with the change in the concentration of uric acid. Conclusion: By objectively analyzing the influence of the Antarctic environment on the change of intestinal microbiota, we were able to provide theoretical support for subsequent Antarctic related research. [ABSTRACT FROM AUTHOR]

Background: Digital technology has a two-sided impact whether it is used appropriately or not. It is crucial to promote the benefits of digital technology and reduce its harms by bolstering adolescents' digital literacy. The appropriateness of the strategies parents use to manage their children's digital lives plays a key role. This study aims to investigate the separate effects of family socio-demographic factors and varied dimensions of parental mediation on adolescents' digital literacy separately and simultaneously to explore the appropriate parental mediation strategies even in the absence of favorable family status. Methods: A cross-sectional survey was utilized with a sample of 1894 Chinese adolescents in junior and senior high schools (mean age = 14.01, 48.94% female), using a set of exam questions to test children's objective digital literacy online. Family socio-demographic factors (parental marital status, economic status, and parental education levels) and varied dimensions of parental mediation were included as predictors of digital literacy. Hierarchical regression analysis was used to estimate the relation between the variables. Results: Higher parental education levels were positively associated with adolescents' parental mediation and digital literacy while better family economic status and parental divorce were negatively associated. Among the dimensions of parental mediation, active mediation, restrictive mediation and supervision were significantly associated with adolescents' digital literacy, but not for co-use. Active mediation and supervision showed significant positive associations with adolescents' digital literacy, whereas, co-use showed a significant negative association when all parental mediation dimensions were integrated into the model, The significant association between restrictive mediation and digital literacy disappeared. Parental mediation has diluted the impact of family socio-demographic factors on adolescents' digital literacy. Conclusions: Effective interventions are needed to promote parental active mediation and supervision to help adolescents develop digital literacy and navigate the digital world, especially for adolescents who do not have highly educated parents or whose parents are divorced. Highlights: This study explored the effects of parental mediation on the digital literacy of adolescents separately and simultaneously in China and highlighted the importance of promoting parental mediation when helping adolescents navigate the digital world, especially those who lack resources, confidence, experience or expertise related to digital media. This study set an online test to estimate adolescents' objective digital literacy. [ABSTRACT FROM AUTHOR]

We propose that experiencing a lack of personal control will increase people’s preferences for self-similar others and that this effect would be explained by a greater need for structure. Our hypotheses received support across 11 longitudinal, experimental, and archival studies composed of data from 60 countries (5 preregistered studies, N = 90,216). In an analysis of cross-country archival data, we found that respondents who indicated a lower sense of personal control were less likely to prefer to live with neighbors who had a different religion, race, or spoke a different language (Study 1). Study 2 found that participants who perceived lower (vs. higher) personal control indicated greater liking for coworkers who they perceived to be more self-similar across a wide range of characteristics (e.g., gender, personality). Studies 3a and 3b, two live-interaction experiments conducted in the United States and China, provided additional causal evidence for control-motivated similarity attraction. A causal experimental chain (Studies 4a to 4c) and a manipulation-of-mediation-as-a-moderator study (Study 5) provided evidence for the mediating effects of the need for structure. Study 6, a longitudinal study with Chinese employees, found that workers who reported perceiving a lower (vs. higher) sense of personal control preferred more self-similar coworkers, and this effect was mediated by a greater desire for structure. Finally, exploring downstream consequences, Studies 7a and 7b found that control-motivated similarity attraction was associated with a greater preference for homogenous (vs. diverse) groups. These findings highlight how the fundamental motive for personal control shapes the structure of social life. [ABSTRACT FROM AUTHOR]

Background: Uncorrected refractive error (URE) is one of the main causes of visual impairments. URE may reduce interaction and learning in the classroom, leading to social isolation, irreversible amblyopia, lack of external knowledge, and restrictions on education and employment opportunities. Our aim was to investigate the prevalence and related factors of URE in adolescents using epidemiological surveys and questionnaire surveys related to lifestyle habits. Methods: A cross-sectional school-based study was conducted in Nantong, China, including adolescents 12–19 years of age from 16 schools. URE was defined as presenting visual acuity worse than 6/12 and improving to ≥ 1 lines after correction in either eye. Univariate and multivariate logistic regression analyses were used to investigate specific correlations between URE and related lifestyle parameters. Non-cycloplegic autorefraction was assessed for each adolescent. Results: A total of 2,910 adolescents were analyzed, of which 50.3% (n = 1,465) were male, and 49.7% (n = 1,445) were female. The mean age was 15.23 ± 1.77 years. The overall prevalence of URE was 23.7%. The total prevalence of REC and eREC was 85.1% and 71.7%, respectively, and both of them showed an increasing trend with age (Ptrend = 0.018 and Ptrend = 0.019, respectively). A higher prevalence of URE was related to myopia, anisometropia, and increased daily use of electronic products. Timely visual examination by medical institutions, more extracurricular homework, and older age were protective factors for URE. Among the 689 adolescents with URE, 362 (52.5%) did not receive any refractive correction, and 327 (47.5%) used corrected glasses. Conclusion: URE was highly prevalent among adolescents in China. Myopia was the most important risk factor for URE. The impact of anisometropia and increased daily use of electronic devices on URE was significant. Timely visual examinations by medical institutions served as an effective protective factor against URE. Further research on adjusting intervention strategies is therefore needed to eliminate preventable visual impairments. [ABSTRACT FROM AUTHOR]

Background: Reliable estimates of asthma prevalence are essential for developing effective public health policies. However, discrepancies in published results have posed challenges for public health planning in China. To address this issue, we conducted this study to provide a comprehensive assessment of the epidemiology of asthma prevalence in China. Methods: We conducted a thorough systematic review across multiple databases including PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI), Wanfang Data, and Weipu database. The search was limited to studies published in either Chinese or English up to August 31, 2023, that reported on asthma prevalence in China. We extracted relevant study characteristics and performed meta-analyses. The study protocol was registered with PROSPERO (CRD42023397949). Results: A literature search yielded 192 studies that met the inclusion criteria out of 17,152 articles. The overall prevalence of asthma in Mainland China was found to be 2.20% (95% confidence interval, CI: 1.96-2.47%; I2 = 99.8%), with the prevalence of ever asthma at 2.21%, current asthma at 2.16%, ever asthma-like symptoms at 14.36%, and current asthma-like symptoms at 3.01%. Using a random-effects model, the prediction interval ranged from 0.44 to 10.27%. Meta-analysis subgroups indicated that men or children and the elderly generally have a higher prevalence of asthma. In addition, the prevalence of asthma is higher in urban areas and in the East China. The prevalence of asthma has been on the rise over the past three decades, from 0.69% in 1984 to 5.30% in 2021. Projections suggest that the prevalence could reach 9.76% by 2050 for the Chinese population. Conclusions: Asthma remains less prevalent in China than in western countries, however its prevalence has been gradually increasing over the past thirty years. The disease burden shows notable variations based on sex, age, and geographic regions, indicating significant demographic and regional disparities. To guide decision-making priorities and direct future research, conducting high-quality epidemiological studies on asthma is crucial. Key message: •The overall prevalence rate of asthma in China is 2.20%, and a higher rate observed in males compared to females. •The prevalence rate of asthma varied across different regions of China. •There has been an increasing trend in asthma prevalence in China over the past three decades. •The prevalence of asthma in China is projected to reach 9.76% by 2050. [ABSTRACT FROM AUTHOR]

Despite the increasing prevalence of online health information seeking (OHIS) among older adults, its impact on patient-centered communication (PCC) outcomes remains unclear. Drawing from Street’s ecological framework of communication in medical encounters, the present study examined the mediation role of patient activation in the relationship between OHIS across three media channels – social media, search engines, and mobile health applications (mHealth apps) – and PCC. Furthermore, it examines the moderation effect of patient-provider discussions of online health information. A national survey of 916 older Chinese adults aged 60–78 was conducted. The findings indicate that OHIS across the three channels can indirectly enhance PCC through patient activation. Moreover, OHIS via mHealth apps is positively associated with PCC, while the relationship between OHIS via social media/search engines and PCC is not significant. The interaction between patients and healthcare providers regarding online health information positively moderated all indirect paths. Notably, a great proportion of older adults (77.7%) engaged in discussions about online health information with healthcare providers. These findings emphasize the importance of considering various media channels and highlight the pivotal role of patient activation in bridging the gap between OHIS and satisfactory healthcare interactions, especially in the Chinese context. [ABSTRACT FROM AUTHOR]

Background: Depressive symptoms are common in adolescents, while its prevalence trend in adolescents is seldom reported. In addition, few studies focus on adolescents without depressive symptoms. This study aimed to reveal the trend and predictors of persistent depression/non-depression among Chinese adolescents over three-year period. Methods: Three-wave data were collected from T1 to T3 in a sample from six junior high schools in Shenzhen, China. The 20-item of Center for Epidemiologic Studies Depression Scale was used, with scoring ≥16 as depression. Results: Of all 1301 adolescents, 33.4%, 15.5% and 9.0% reported depressive symptoms at baseline, T2 and T3 respectively, while 66.6%, 47.7% and 39.6% reported non-depressive symptoms at three time-points. At the individual level, baseline positive identity and general positive youth development significantly increased persistent non-depression at T2 and T3. At the family level, baseline family harmony and communication consistently prevented persistent depression at T2 and T3, while family communication consistently promoted non-depression. At the school level, baseline awareness of no expectation from teacher and poor interpersonal relationship consistently increased persistent depression and prevented non-depression. Conclusions: The incidence of depression in adolescents aged 11–15 is not high. The rate of persistent non-depression is approximately 30% higher than that of persistent depression, and both have a downward trend over years. Positive youth development and healthy family function are protective factors of depression, while school maladjustment decreases persistent non-depression. During early adolescence, more attention should be paid to family function and school maladjustment to promote non-depression in adolescents from a new broader view. [ABSTRACT FROM AUTHOR]

Small cell carcinoma of the bladder (SCCB) is a rare, highly malignant neuroendocrine tumor. This study attempted to analyze tumor characteristics, treatments and clinical outcomes in China. We conducted a retrospective analysis of patients diagnosed with non-metastatic SCCB at multi-institutions between January 2007 and January 2022. The Kaplan-Meier method was used to calculate survival. A total of 20 patients were included. 10 had localized disease (T1-2N0), and 10 had locally advanced disease (≥ T3 or N+). 13 received local treatment (partial cystectomy or transurethral resection of the bladder tumor) and 7 received radical treatment (radical cystectomy or radiotherapy). A total of 18 patients (90%) received chemotherapy (CT), either neoadjuvant CT (n = 5) or adjuvant CT (n = 13). The median OS for the receiving local treatment was 65.3 months (95% CI 0 to 138 months) and the corresponding 1-year, 2-year, and 3-year OS was 77%, 54%, and 54%, respectively. The median OS for the receiving radical treatment was not reached and the corresponding 1-year, 2-year, and 3-year OS was 100%, 100%, and 75%, respectively. The median PFS for receiving local treatment was 13.8 months (95% CI 9.3 to 18.3 months) and the corresponding 1-year, 2-year, and 3-year PFS was 46%, 31%, and 31%, respectively. The median PFS for the receiving radical treatment was not reached and the corresponding 1-year, 2-year, and 3-year PFS was 83%, 56%, and 56%, respectively. This study reported the largest cohort of non-metastatic SCCB among Chinese population. Given its metastatic potential, CT remained an essential part of the treatment. The survival outcomes of radical cystectomy and RT in non-metastatic SCCB were encouraging. [ABSTRACT FROM AUTHOR]

AbstractBackgroundAimsMethodsResultsConclusionsThe association between objective imaging findings and subjective symptoms remains undefined.To investigate the correlation between objective imaging findings and symptom severity in the overall chronic rhinosinusitis with nasal polyps (CRSwNP) population as well as its subendotypes according to the eosinophilic inflammation.Patients with CRSwNP undergoing endoscopic sinus surgery were included. All participants completed the Sino-Nasal Outcome Test (SNOT-22) questionnaire. The Lund-Mackay (LM) CT scores was also obtained. Spearman correlation analysis was performed to evaluate the correlation between CT scores and SNOT-22 scores.Forty-four non-eosinophilic CRSwNP(neCRSwNP) and 93 eosinophilic CRSwNP (eCRSwNP) patients were recruited. There was significant association between LM total score and nasal subdomain of SNOT-22 in the overall CRSwNP patients. The nasal symptom of SNOT-22 was significantly associated with maxillary, frontal, sphenoid, anterior drainage, and posterior drainage in all CRSwNP patients. In eCRSwNP and neCRSwNP patients, the sense of smell/taste was associated with sphenoid and posterior drainage. Thick nasal discharge was positively correlated with maxillary, frontal, and anterior drainage only in eCRSwNP patients.The high score of sphenoid and posterior drainage may suggest the occurrence of loss of sense of smell/taste, while high score of maxillary sinus may indicate suffering from thick nasal discharge in eCRSwNP patients. [ABSTRACT FROM AUTHOR]

Introduction: Although a number of scholars have examined the theoretical pathways between green space (GS) and mental health, few have focused on how campus greenness affects the mental health of Chinese youth. Methods: Herein, two objective indicators, campus and individual 300-m normalized vegetation index (NDVI) data, were used as independent variables. A questionnaire was used to collect the self-rated anxiety level of students on campuses in Nanjing. Then, we chose “subjective perception of campus GS”, “physical activity”, “social cohesion”, “nature relatedness” and “usage pattern” as mediating variables to explore the pathways between the campus greenery and college student’ anxiety level through correlation analysis, linear regression, and mediation effect test. Results: Results showed the campus-wide NDVI and individual students’ 300-m range NDVI had significant negative correlations with anxiety (p = 0.045, p = 0.023). Campus perception, nature relatedness and the frequency of using GS are the pathways through which campus GSs influence student anxiety. Discussion: Our findings emphasised the importance of subjective perceptions of greenspaces, which provided a direction that can be deepened in future research. [ABSTRACT FROM AUTHOR]

This paper discusses the political positioning of the people and the cultural image of the Chinese nation through the lens of the Social-historical Scientific Documentary Films of China's ethnic minorities (hereafter referred to as "the Ethno-documentaries") by restoring the problem to the site of the investigation of humanities and social sciences and the General Surveys on (Folk) Arts in the early years of the establishment of the People's Republic of China in the 1950s. Through detailed analysis of specific Ethno-documentary films, this paper explores how the social sciences conducted its "Social and Historical Investigation of China's Ethnic Minorities" via the medium of film to convey the advanced social concepts and ideological work of the new regime through the historical narrative of art and politics. This study highlights three key points. First, the "Chinese nation" as a modern political concept dates its origins back to the 1920s with the emergence of the "National Heritage Reorganization Movement" and the "Doubting Antiquity School." However, it was only through the medium of the Ethno-documentaries that this concept was visually and aurally represented in films for the first time, which draws our attention to the fact that the entry point for understanding modern China lies in discerning the relationship between culture and politics. Second, when discussing the relationship between culture and politics, this study juxtaposes the Ethno-documentaries and "art for workers-peasants-soldiers," which developed during the same period. These two forms of art focus respectively on national history and the suffering of the lower classes of society, and it is this intertextual nature of the historical narrative that jointly anchors the cultural and historical view of New China. Lastly, historical view is the core of the humanities, social sciences, and art disciplines in New China. Previous studies have mainly attributed certain phenomena to the "politicization" or "pan-politicization" of a particular historical period due to disciplinary barriers and cultural trauma and have stopped discussing such topics in depth. In contrast, the significance of the political aesthetics in the Ethno-documentaries is to have transformed classical Chinese artistic language into a modern one to represent the Chinese people and the Chinese nation. It also raises a question of re-sinicization of many modern political issues that have persisted until now: How do today's Chinese art works vividly depict the prosperity of this country and its hardworking and courageous people? [ABSTRACT FROM AUTHOR]

Background: Asparaginase-associated pancreatitis (AAP) is a major challenge for continuing asparaginase therapy. We aimed to investigate the acute and longterm complications and survival rates related to first and second AAP episodes in Chinese children with haematological malignancies. Methods: We retrospectively analysed clinical data of children with pancreatitis who received asparaginase chemotherapy for acute lymphoblastic leukaemia (ALL), acute mixed cell leukaemia, and non-Hodgkin's lymphoma at Shanghai Children's Medical Center from November 2013 to November 2023. Results: Of the 76 children included in the study, 12 had local complications (15.79%), with no deaths recorded. Systemic complications manifested in 28 patients (36.84%), resulting in 3 deaths (3.95%). Four patients (5.26%) developed long-term complications (chronic pancreatitis or insulin-dependent diabetes mellitus). No significant differences in local or long-term complications were recorded between children in the asparaginase re-exposed (n=39) and non-reexposed (n=45) groups. Among the re-exposed patients, eight (25.81%) experienced a second attack without fatalities or complications. Survival analysis of intermediate-to high-risk patients revealed a significantly higher event-free survival (EFS) rate for the re-exposed group than for the non-reexposed group. The second AAP episode's occurrence and severity had no relation to the first AAP episode's severity, and the second AAP episode was significantly less severe than the first (p<0.001). Conclusions: The second AAP episode's occurrence is unrelated to the first AAP episode's severity, and the second AAP episode's severity is significantly lower than that of the first. Further, asparaginase therapy could improve EFS in children with intermediate and high-risk ALL. [ABSTRACT FROM AUTHOR]

Background and Aims Despite advances in technology and techniques, the recurrence rate of persistent atrial fibrillation (AF) following catheter ablation remains high. The Shensong Yangxin (SSYX) capsule, a renowned traditional Chinese medicine formula, is used in the treatment of cardiac arrhythmias. This trial aimed to investigate whether the SSYX can improve clinical outcomes in patients who have undergone catheter ablation for persistent AF. Methods A multi-centre, randomized, double-blind, placebo-controlled clinical trial was conducted at 66 centres in China among 920 patients with persistent AF undergoing first ablation. Participants were randomized to oral SSYX, 1.6 g (.4 g/granule) thrice daily (n = 460), or matched placebo (n = 460) for 12 months. The primary endpoint was recurrent atrial tachyarrhythmias lasting for ≥30 s following a blanking period of 3 months. Secondary endpoints included time to first documented atrial tachyarrhythmias, AF burden, cardioversion, stroke/systemic embolism, changes in echocardiographic parameters, and quality-of-life (QoL) score. Analyses were performed according to the intention-to-treat principle. Results A total of 920 patients underwent randomization (460 assigned to SSYX group and 460 assigned to placebo group). During the follow-up of 12 months, patients assigned to SSYX had a higher event-free rate from recurrent atrial tachyarrhythmias when compared with the placebo group (12-month Kaplan–Meier event-free rate estimates, 85.5% and 77.7%, respectively; hazard ratio,.6; 95% confidence interval.4–.8; P =.001). Patients assigned to receive SSYX had a better QoL score at 12 months compared to those randomized to placebo. There was no significant difference in the incidence of serious adverse events between the two groups. Conclusions Treatment with SSYX following radiofrequency catheter ablation for persistent AF reduced the incidence of recurrent atrial tachyarrhythmias and led to clinically significant improvements in QoL during a 12-month follow-up in a Chinese population. [ABSTRACT FROM AUTHOR]

Introduction: Gaming disorder (GD) in adolescents is associated with impaired interpersonal relationships, including those with parents, teachers and peers. However, the interpersonal relationships most strongly associated with GDrelated maladaptive behaviors are not well established. This study aimed to investigate the associations between these three types of relationships and the manifestation of GD in adolescents. Methods: In this cross-sectional study, 1920 Chinese adolescents participated in a survey that assessed interpersonal relationships (parent--child, teacher--student, and peer relationships) and demographic variables (e.g., gender, grade, duration of gaming), and 1414 participants were ultimately included. A network analysis approach was utilized to evaluate the key network metrics of edge weight and node centrality. Results: The findings revealed that peer fear and inferiority (r = 0.12) and teacher--student conflict were most strongly correlated with GD, followed by parent --child conflict (r = 0.09). Peer fear and inferiority exhibited the highest strength centrality (0.84), followed by teacher--student conflict (0.83) and parent--child conflict (0.35). Moreover, the duration of gaming was significantly and positively correlated with GD (r = 0.19). Conclusions: The present study underscores the significant role of conflict and rejection within interpersonal relationships, particularly among peers, in the manifestation of GD-related behaviors in Chinese adolescents. [ABSTRACT FROM AUTHOR]

This study aimed to examine the association of chronic disease with depressive symptoms, while taking emotion regulation as a moderator, and to further explore gender and grade differences in the moderating effects of emotion regulation among Chinese adolescents. An extensive online survey was carried out in northwestern China. Our analyses included a total of 20,432 students. Multivariable linear regression analyses were performed to explore the relationship between chronic disease and depressive symptoms, as well as the impact of emotion regulation on these associations. This study discovered that chronic disease could significantly increase depressive symptoms in adolescents [β = 0.108, 95% CI (0.096, 0.120)]. Suppression strengthened the relationship between chronic disease and depressive symptoms [β = 0.116, 95% CI (0.104, 0.128), p < 0.001]. The positive moderating effects of reappraisal were only found in girls [β = -0.022, 95% CI (-0.041, -0.004)], whereas its reversed moderating impact was observed in boys [β = 0.022, 95% CI (0.006, 0.037)]. In terms of grade difference, suppression was significant only for middle school and high school students. Chronic disease is the risk factor for depressive symptoms among adolescents in northwestern China. Suppression and reappraisal moderated this relationship in different ways depending on gender and grade. The mental health of adolescents with chronic diseases should be closely monitored. Relative interventions aimed at improving emotion regulation may effectively reduce depressive symptoms. [ABSTRACT FROM AUTHOR]

The present research examined cultural differences of co-rumination in predicting psychological well-being between 331 Chinese and 166 Australian college students. Results of comparative analyses indicated three higher positive co-rumination factors (i.e., affirmation, problem-solving, and enhancing friendship), one higher negative co-rumination factor (i.e., inhibiting happiness), but one lower negative co-rumination factor (i.e., worry about evaluation) in Chinese participants, than in Australian participants. The neutral factors of co-rumination (i.e., frequency P and N) did not show group differences. Regression analyses indicated that affirmation and problem-solving were positive predictors whereas worry about evaluation, and slack were negative predictors for Chinese participants. Affirmation, problem-solving, and enhancing friendship were positive predictors whereas worry about evaluation, inhibiting happiness, and slack were negative predictors for Australian participants. Overall, these findings indicate that different strategies of co-rumination have different relationships with psychological well-being while highlighting important differences between East and West cultures. [ABSTRACT FROM AUTHOR]

The research community is expressing an increasing concern about the negative outcomes of ostracism. However, how and when ostracism is associated with adolescents' depression remains to be identified. Guided by the Temporal Need-threat Model, this study aimed to investigate the link between ostracism and depression, and to explore this influencing mechanism further with maladaptive cognitive emotion regulation strategies (maladaptive CERSs) and self-compassion tested as a mediator and a moderator respectively. In a cross-sectional survey, a total of 2,057 Chinese adolescents (1,185 females, Mage = 13.88, SDage = 1.28) completed questionnaires regarding ostracism, maladaptive CERSs, self-compassion, and depression. Our hypotheses were tested by model 4 and model 59 of the PROCESS macro. The present study found that ostracism is positively linked to depression, and maladaptive CERSs played a mediating role in this relationship. Furthermore, self-compassion weakened the strength between ostracism and both depression and maladaptive CERSs, as well as between maladaptive CERSs and depression. These findings provide a theoretical and empirical basis for developing intervention strategies to reduce the negative effects of ostracism. [ABSTRACT FROM AUTHOR]

This study examined the effect of extraversion and DIAMONDS situation characteristics, including Duty, Intellect, Adversity, Mating, Positivity, Negativity, Deception, and Sociality, on state happiness among Chinese participants. With a daily diary design, Study 1 established the relation between extraversion and daily happiness. With an experience sampling design, Study 2 not only replicated the positive relation between extraversion and state happiness, but also extend this conclusion by examining the effects of DIAMONDS situation characteristics on momentary happiness. Specifically, mating, positivity and sociality positively predicted momentary happiness, whereas adversity, negativity and deception negatively predicted momentary happiness. Duty and intellect were not related to momentary happiness. Interactions between extraversion and situation characteristics were also examined. Implications and limitations of this research are discussed. [ABSTRACT FROM AUTHOR]

AbstractThirty-four Chinese families (each consisting of a mother and two children) were recruited to participate in this study. The firstborn children had an average age of 12.00 ± 2.07 years, while the second-born children averaged 7.57 ± 2.51 years old. The families were randomly divided into mediation and control groups. The mothers in the mediation group underwent mediation training, whereas those in the control group received no treatment. Analysis of variance (ANOVA) and Chi-square tests were utilized to analyze data on sibling conflict. Results indicated that the mothers in the mediation group reported significantly less negative behavior in helping their children resolve sibling disputes compared to those in the control group. Mediation group mothers reported significantly fewer sibling conflicts compared to control group mothers. No significant differences were observed between children in the mediation group and the control group regarding positive and negative behaviors recorded by mothers. These results indicate that mediation training may better equip Chinese mothers with the ability to resolve sibling conflicts in their families. [ABSTRACT FROM AUTHOR]

Thyroid hormones (THs) may affect chronic thyrotoxic myopathy (CTM). The relationship between TH sensitivity and CTM is inconsistent. We aimed to investigate the associations between TH sensitivity and the risk of CTM and to screen potential CTMs with strength and function tests. A total of 162 Chinese patients (36.58% men) with Graves' disease were enrolled and divided into CTM and non-CTM groups. TH and sensitivity indices were measured. Muscle power and function were assessed by grip, upper-limb fatigue (ULFT), lower-limb fatigue (LLFT), and squat-up (SUT) tests, and walking pace. Association between sensitivity to TH indices and the risk of developing CTM was assessed via multivariate logistic regression. The diagnostic effectiveness of muscle power and function for predicting CTM was evaluated via receiver operating characteristic (ROC) curves. Thyroid feedback quantile-based index FT3 (TFQIFT3) and the parametric TFQIFT3 (PTFQIFT3), TFQIFT4, and PTFQIFT4 were positively associated with CTM risk by using inverse probability of treatment weighting multivariate logistic regression. For each 1-SD increase in TFQIFT3 and PTFQIFT3, TFQIFT4 and PTFQIFT4, the odds ratios for CTM were 1.67 (95% CI = 1.17–2.48) ,1.64 (95% CI = 1.51–2.93), 1.60 (95%CI = 1.12–2.32), 1.58 (95%CI = 1.11–2.30), respectively. LLFT and SUT best predicted male/female CTM, respectively (AUC = 0.89/0.85). In Graves' disease patients, TH sensitivity is associated with CTM development, which can be predicted by SUT and LLFT results. [ABSTRACT FROM AUTHOR]

Background: Pitt–Hopkins syndrome (PTHS) is a rare genetic condition caused by a mutation in the transcription Factor 4 (TCF4) gene and characterized by its unique clinical presentations. At present, there is an incomplete understanding of the possible TCF4 mutations and their downstream consequences, and no reliable treatment exists for patients with PTHS. Elucidating the variations in TCF4 occurring in PTHS could lead to new treatment ideas. Case presentation: We described the clinical and genetic characteristics of four Chinese patients with PTHS. Genetic mutations related to central nervous system (CNS) disorders were identified via high-throughput sequencing. The patient's mutations were subsequently confirmed with Sanger sequencing. Most patients had facial features typical of PTHS; however, Patient 2 demonstrated poor auricle shape. Each patient presented with differing levels of delayed development and intellectual impairment. The patients showed a splice site mutation in intron 15 of TCF4 (c.1452 + 3A > G), a frameshift mutation in exon 18 of TCF4 (c.1942delA), and two missense mutations in exon 19 of TCF4 (c. 2147C > T and c.2026A > G). Conclusions: We discovered four new TCF4 mutations in Chinese children with PTHS. To our knowledge, the c.2026A > G and c.1942delA mutations have not yet been reported. The detection of these mutations can help accurately diagnose PTHS early, especially in patients whose clinical symptoms are not obvious. Exploring the genotype and phenotype of individuals with PTHS, will enrich our understanding and guide further research into the role of TCH4. [ABSTRACT FROM AUTHOR]

Intolerance of uncertainty (IU), a pivotal transdiagnostic risk factor in psychopathology, is defined as a dispositional incapacity to withstand uncertainty distress, driving maladaptive cognitive, emotional and behavioural reactions to uncertainty. However, the intricate interplay among these components, particularly in adolescents, remains underexplored; yet understanding this interplay is crucial for supporting mental health. To address this gap, we employed a network approach to conceptualize IU in 5672 non‐clinical Chinese adolescents (Mage = 14.13 years, SDage = 1.96 years, range = 10–19 years, 46.6% boys), combining graphical Gaussian models (GGM) and directed acyclic graphs (DAG). Our analyses revealed a tripartite network comprising cognitive, behavioural and emotional components. Notably, ‘frustration’ and ‘work with hindrance’ emerged as key drivers, while ‘catastrophizing belief’ served as a critical bridge linking different components. These findings underscore the importance of alleviating uncertainty‐induced frustration and enhancing coping skills for behavioural impediments to mitigate adolescent IU. Additionally, therapeutic interventions should prioritize modifying and re‐evaluating catastrophizing beliefs related to uncertainty. [ABSTRACT FROM AUTHOR]

The complexity of the idea of a university has been intensified globally as more universities pursue entrepreneurship. For modern universities in China as latecomers, contemporary entrepreneurial reforms are implemented against a backdrop of ongoing interactions between Chinese and Western ideas of a university, with the Western established as the formal system and the Chinese functioning informally yet powerfully. Through 71 semi-structured interviews at four universities in the Guangdong-Hong Kong-Macao Greater Bay Area, this study explores how academic freedom and institutional autonomy are perceived by Chinese academics under entrepreneurial reforms. The study has two major findings through Clark’s analytical framework of academic, government, and market forces: (1) A novel form of statist academic freedom is emerging, merging traditional Chinese scholarly values with state-driven entrepreneurial demands; (2) The adapted triple helix model in China emphasises competition and excellence, shaped by a unique blend of state influence and market dynamics. It offers a nuanced perspective on academic freedom and institutional autonomy amidst entrepreneurial reforms in China, highlighting a compatibility with Chinese idea of a university and a response to global entrepreneurial pressures. [ABSTRACT FROM AUTHOR]

Objective: We aim to estimate the prevalence of baseline clinically significant distress in Chinese patients with head and neck squamous cell carcinoma (HNSCC) before receiving the first radiotherapy and assess factors predictive of distress. Methods: One hundred and sixty-eight patients were enrolled to complete a set of questionnaires including Distress Thermometer (DT) and Hospital Anxiety and Depression Scale (HADS). Of these, 131 questionnaires were available for the final analysis. The accuracy of DT was validated using HADS as the gold standard, and receiver operating characteristic (ROC) curves were employed to identify the optimal cutoff score of DT. Results: Distress was reported in sixty-two patients (47%). Patients who were visited in the last week (p = 0.022) and those with medical-related occupations (p = 0.017) were less likely to suffer from psychological distress. Additionally, religious belief was negatively associated with both the DT and HADS-T scores, indicating that patients with religious beliefs were less likely to report high levels of distress (odds ratio (OR) for DT ≥ 4 = 0.291, p = 0.039; OR for HADS-T ≥ 15 = 0.316, p = 0.047). Factors such as age, gender, marital status, education and residency did not contribute to distress levels. DT was significantly correlated with HADS-T (Correlation coefficient (r) = 0.624, p < 0.001) and the best cutoff score of DT was 4 in screening distress. Conclusions: DT was a brief and effective tool to screen distress among HNSCC patients. [ABSTRACT FROM AUTHOR]

Background: Prior research has found that children with attention-deficit hyperactivity disorder (ADHD) and reading difficulties (RD) are at an elevated risk of developing further cognitive deficits and developmental challenges [1]. ADHD and RD are characterized by a deficit in working memory, which negatively affects learning and behavior. The main aims of this study were to design a working memory training app and examine its effectiveness through a 5-week training program in Chinese children with ADHD and/or RD. Methods: There were three experimental groups, with 26 participants in the ADHD group, 38 participants in the RD group, and 24 participants in the ADHD + RD group. The typically developing (TD) control group had 32 participants. All participants completed the pretest and posttest assessments on executive function and reading performance. Results: The findings indicate that the experimental groups improved performance in verbal and visual-spatial working memory as well as Chinese word reading. There was an overall reduction in functional impairment following the training, in contrast to the TD group. Conclusion: This study showed that working memory can be improved through computerized training in children with ADHD and/or RD. The implications of future research in working memory are discussed. Trial registration: Clinical Trials Identifier: NCT06567444 (retrospectively registered) on 20 August 2024. [ABSTRACT FROM AUTHOR]

Solid fuel combustion exposure is a leading global health risk factor, yet evidence on its effects, especially on vulnerable children, is sparse. This large-scale, multi-center prospective study aimed to address this gap by involving 9997 schoolchildren across China between 2013 and 2015. Here we show that lung function levels exhibited a marginally significant decline among children exposed to solid fuel usage. Specifically, FVC and FEV1 decreased by 21.2 mL (95% CI: −15.7, 58.1) and 24.1 mL (−8.4, 56.6), respectively. Additionally, PEF, FEF25 and FEF75 decreased by 25.7 mL/s (−46.5, 98.0), 32.7 mL/s (−42.7, 108.2), and 35.4 mL/s (−5.9, 76.7), respectively. Persistent exposure to solid fuel usage in children led to greater lung damage. Children with allergy history were more susceptible to solid fuel exposure. Our study highlights the adverse impact of solid fuel usage on children and the need to promote clean fuel usage for this vulnerable population. This study of 9,997 Chinese children (2013–2015) found that solid fuel exposure led to marginally significant declines in lung function, with higher risk for children with persistent exposure or allergies, highlighting the need for clean fuel use. [ABSTRACT FROM AUTHOR]

Background: Social engagement is closely related to well-being among older adults. However, studies on the changing trajectory and influencing factors (especially time-varying factors) of social engagement are limited. This study aimed to examine the social engagement trajectory of older Chinese adults and explore its time-fixed and time-varying factors, thus providing evidence for the development of strategies to promote a rational implementation for healthy aging. Methods: This study included 2,195 participants from a subset of four surveys from the Chinese Longitudinal Healthy Longevity Survey conducted from 2008 to 2018 (with the latest survey completed in 2018), with follow-ups conducted approximately every three years. Growth mixture modeling was used to explore the social engagement trajectory of older adults and the effects of time-varying variables. In addition, multinomial logistic regression was employed to analyze the association between time-fixed variables and latent classes. Results: Three distinct trajectories of social engagement among older adults in China were identified: slow declining (n = 204; 9.3%), which meant social engagement score decreased continuously, but social engagement level improved; slow rising (n = 1,039; 47.3%), marked by an increased score of social engagement, but with an depressed engagement level; and middle stabilizing (n = 952; 43.4%), which meant social engagement score and engagement level remained quite stable. A time-fixed analysis indicated that age, marital status, educational level, and annual family income had a significant impact on social engagement (P < 0.05). In contrast, the time-varying analysis showed that a decline in functional ability, insufficient exercise (means no exercise at present), deteriorating self-reported health and quality of life, negative mood, monotonous diet, and reduced community services were closely related to the reduction in social engagement levels (P < 0.05). Conclusion: Three trends were observed at the social engagement level. Older adults with initially high levels of social engagement exhibited a continuous upward trend, whereas those with initially low levels experienced a decline in their social engagement, and those with initially intermediate levels remained quite stable. Considering the primary heterogeneous factors, it is imperative for governments to enhance basic services and prioritize the well-being of older adults. Additionally, families should diligently monitor the emotional well-being of older adults and make appropriate arrangements for meals. [ABSTRACT FROM AUTHOR]

Background: Uric acid as a prominent causal factor in the pathogenesis of hypertension is well recognized. Nevertheless, the influence of uric acid on the transition from prehypertension to hypertension within the Chinese population remains understudied. Methods: A cohort of 1,516 prehypertensive individuals, aged 35 to 84 years, underwent recruitment following a comprehensive health assessment in 2017 and subsequent re-evaluation in 2022. Baseline characteristics and relevant clinical data were collected. The analytical approach encompassed multiple logistic regression and propensity score matching. Results: Over 5 years, the cumulative incidence of hypertension amounted to 35.1%, with 33.9% in males and 37.3% in females, respectively. Notably, prehypertensive subjects concomitant with hyperuricemia exhibited a higher cumulative incidence of hypertension in comparison to the non-hyperuricemic counterparts (40.7% vs. 34.0%, p = 0.041). Multiple logistic regression unveiled a significant association between hyperuricemia and heightened hypertension risk (adjusted odds ratio [OR] = 1.44; 95% confidence interval [CI], 1.05–1.98; p = 0.022). Nonetheless, this association did not reach statistical significance when examining female subjects (adjusted OR = 1.10; 95% CI, 0.58–2.09; p = 0.781) or participants aged ≥ 60 years (adjusted OR = 1.07; 95% CI, 0.61–1.88; p = 0.814). Further validation through propensity score matching affirmed that subjects afflicted by hyperuricemia experienced a substantially elevated risk of transitioning from prehypertension to hypertension over the course of five years compared with the non-hyperuricemic counterparts (41.3% vs. 32.3%, p = 0.045), after adjusting for 12 covariates including age and gender. Hyperuricemia emerged as an independent risk factor predisposing individuals to the development of hypertension from a prehypertensive state. Conclusion: This observation prompted the formulation of a hypothesis suggesting that ameliorating elevated uric acid levels may potentially mitigate the progression from prehypertension to hypertension. [ABSTRACT FROM AUTHOR]

Aim Methods Results Conclusions Vitamin D is an essential micronutrient for multiple physiological processes, and its deficiency remains a world‐wide public health problem that cannot be ignored. Dried blood spot (DBS) is a convenient tool in large‐scale epidemiological studies, but its application in evaluating vitamin D status in Chinese population is still scarce. Herein, we aimed to determine the vitamin D status in Chinese pre‐school children using DBS coupled with LC‐MS/MS method.We first developed a sensitive and reliable method for the determination of 25‐hydroxyvitamin D (25(OH)D) in DBS samples using an ultra‐high‐performance liquid chromatograph coupled with triple quadrupole mass spectrometer (UHPLC‐QQQ‐MS/MS). Next, we conducted a pilot study to compare the 25(OH)D concentration in DBS and serum samples. Finally, the assay method was used to evaluate vitamin D status in Chinese pre‐school children.The present method was validated to be reliable and robust for the determination of 25(OH)D in DBS samples. Comparable consistency was observed between the 25(OH)D concentration in DBS and serum samples. A total of 3826 DBS samples collected from children aged 1–7 years were determined. The median concentration of 25(OH)D was 19.57 ng/mL (interquartile range 14.73–24.36 ng/mL), and decreased from 1 to 7 years of age. In addition, 13.51% of male children and 15.12% female children are found to be deficient in 25(OH)D.DBS coupled with LC‐MS/MS is a feasible strategy to evaluate vitamin D status in epidemiological studies. And vitamin D deficiency remains a common health problem in Chinese pre‐school children. [ABSTRACT FROM AUTHOR]

Over the last 16 years, Central American governments have increasingly embraced diplomatic relations with the People's Republic of China to foster economic opportunities and national development. This analysis builds on ethnographic research in Costa Rica and Guatemala to trace the kinds of entrepreneurialism Central American governments are mobilizing to foment these transpacific commercial relations. This article explores those transpacific spaces and subjects deemed valuable for national development. Though a strong tradition of transnational business connects local ethnic Chinese Central Americans with firms in mainland China and Taiwan, these subjects have largely not been protagonists of incipient state‐led initiatives. I argue that the racialization of Chinese Central American businesspeople as ethnic entrepreneurs has precluded them from serving as appropriate subjects of national development. Instead, Central American governments have relied on white elites to develop desired commercial relations and class interests in this new era of transpacific relations. As such, I emphasize the racialized and classed underpinnings of entrepreneurial identity, showing how it positions some as always already suspect economic actors, while others are seen as national subjects capable of a process of entrepreneurial becoming. [ABSTRACT FROM AUTHOR]

AbstractKolkata, known for its cultural diversity, reflects the inequalities of its informal sector, reminiscent of a feudal system. The city is home to various foreign communities, including Armenians, Jews, Parsis, and particularly the Chinese. Historically, Kolkata saw a significant influx of Chinese immigrants, followed by phases of exclusion. Despite challenges, the Chinese community has thrived for over two decades, contributing to the city’s cultural richness. This research explores how Chinese individuals in Kolkata, unfamiliar with local social structures, perceive and categorize others, defining their ethnic identity. Using both qualitative and quantitative methods, the study finds that many Chinese in Kolkata identify as Indian-Chinese or Chinese-Indians. The community’s evolving belief systems reflect their ongoing search for a cultural identity. Through this exploration, they work to define their core values and roles within society, constantly adapting to the cultural landscape of Kolkata. [ABSTRACT FROM AUTHOR]

Introduction: Hepatitis B is a significant public health concern and a leading cause of liver cancer across the world. In Australia, hepatitis B is largely endemic in migrant communities, particularly amongst the Chinese and Vietnamese communities. Negative attitudes towards hepatitis B can be a major barrier to hepatitis B testing and linkage to care. This mixed-methods research explores the attitudes and beliefs, including stigma, about hepatitis B among students of Vietnamese and Chinese background in Australia. Students were chosen as participants as there is little research examining hepatitis B among university students in Australia and they provide a point of entry to communities with high prevalence of hepatitis B, that otherwise may be hard to access. Methods: Online surveys were distributed in Chinese, Vietnamese, and English via social media and completed by 112 students of Chinese and 95 students of Vietnamese backgrounds. In-depth interviews were also conducted with 13 Vietnamese and 10 Chinese participants to further explore the survey results. Results: Survey findings suggest that students have varied attitudes towards people living with hepatitis B. Around half of the participants reported they would behave negatively towards other people with hepatitis B and that they would expect to experience stigma or discrimination if they had hepatitis B. While over 70% in both samples reported that people who have hepatitis B should not be isolated by family and friends, 47.6% of the Chinese sample and 28.3% of the Vietnamese sample reported they would avoid close contact with someone with hepatitis B. The qualitative data expands on the quantitative data. Four key themes were identified: (1) Caution not discrimination (2) Hepatitis B as a sign of immoral behaviour (3) Discriminatory behaviour based on perceived effects of hepatitis B and (4) Shifting attitudes. Conclusion: This research provides insights that could inform culturally sensitive health promotion programs to address negative attitudes towards hepatitis B among the broader Chinese and Vietnamese communities living in Australia. [ABSTRACT FROM AUTHOR]