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Abstract Background The human apurinic/apyrimidinic endonuclease 1/Redox effector factor-1 (APE1/Ref-1) is implicated in tumor development and progression. Recently, the APE1/Ref-1 promoter -141T/G variant (rs1760944) has been reported to be associated with lung cancer risk. Given the importance of APE1/Ref-1 in both DNA repair and redox activity, we speculate that the -141T/G polymorphism may confer individual susceptibility to gliomas or its subtypes. Methods The APE1/Ref-1 -141T/G polymorphism was analyzed in a case-control study including 766 glioma patients (among them 241 glioblastoma, 284 astrocytomas except for glioblastoma and 241 other gliomas) and 824 cancer-free controls from eastern China. Genotyping was performed with Sequenom MassARRAY iPLEX platform by use of allele-specific MALDI-TOF mass spectrometry assay. We estimated odds ratios (ORs) and 95% confidence intervals (95% CIs) using unconditional logistic regression. A test of trend was calculated using the genotype as an ordinal variable in the regression model. For each statistically significant association identified, we estimated the false positive reporting probability (FPRP). FPRP values less than 0.2 were consider to indicate robust associations. Results The significant association between the APE1/Ref-1 promoter -141T/G polymorphism and glioma risk was not observed. However, the stratified analysis by histology revealed the variant allele G significantly decreased glioblastoma risk (OR = 0.80, 95% CI = 0.65-0.98, P = 0.032). Individuals with the homozygous -141GG genotype exhibited 46% reduced risk of glioblastoma (adjusted OR = 0.54, 95% CI 0.34-0.87, P = 0.012), compared with the TT homozygote. This result remained robust given the prior probabilities of 25% (FPRP = 0.052) and 10% (FPRP = 0.140), but not with a prior probability of 1% (FPRP = 0.643). The P-associated with the trend test was 0.014. Conclusions Our results suggest that a specific genetic variant located in the APE1/Ref-1 promoter may modulate risk of glioblastoma, but not for other histological gliomas. Larger studies with more APE1 polymorphisms are required to validate these preliminary findings.

For multiple-input multiple-output (MIMO) wireless communication system with minimum mean square error (MMSE) detection, a new scheme of power allocation between pilot and data symbols is investigated under MMSE channel estimation in this paper. First, we propose a novel soft-output MMSE MIMO detector by taking into consideration the channel estimation error. Then, through the application of random matrix theorem, we propose an efficient scheme for power allocation between pilot and data symbols which maximizes the lower bound of postprocessing signal-to-interference-and-noise ratio (SINR) for MIMO systems with equal number of transmitter and receiver antennas. We have proven the existence and uniqueness of the proposed optimal power allocation settings. Furthermore, our analysis shows that the proposed power allocation is also valid and applicable for those MIMO systems with unequal number of transmitter and receiver antennas. Finally, our extensive simulation results have validated this novel power allocation scheme.

Abstract While wireless local area network-based indoor localization is attractive, the problems concerning how to capture the signal-propagating character in the complex dynamic environment and how to accommodate the receiver gain difference of different mobile devices are challenging. In this article, we solve these problems by modeling them as common mode noise and develop a localization algorithm based on a novel differential radio map approach. We propose a differential operation to improve the performance of the radio map module, where the location is estimated according to the difference of received signal strength (RSS) instead of RSS itself. The particle filter algorithm is adopted to realize the target localization and tracking task. Furthermore, to calculate the particle weight at arbitrary locations, we propose a local linearization technique to realize continuous interpolation of the radio map. The indoor experiment results demonstrate the effectiveness and robustness of our approach.

Abstract Background Epidermal growth factor (EGF) is critical in cancer process. EGF and EGF receptor (EGFR) interaction plays a pivotal role in cell proliferation, differentiation, and tumorigenesis of epithelial tissues. Variations of the EGF +61G/A (rs4444903) may lead to an alteration in EGF production and/or activity, which can result in individual susceptibility to brain glioma. The purpose of this study was to investigate the potential association between EGF +61G/A and brain glioma in a Chinese population. Methods In this study, we analyzed single nucleotide polymorphism of EGF +61G/A in 677 patients with glioma and 698 gender- and age-matched controls. Genotyping was performed by polymerase chain reaction-ligation detection reaction (PCR-LDR) method. Results The A allele (minor Allele) was 33.0% in cases and 27.3% in controls. The additive model was more powerful to reveal the association in our study than that of recessive and dominant model. Our data showed the genotype G/A and A/A was associated with increased risk for glioma (adjusted OR = 1.48, 95%CI: 1.17-1.87, p = 0.001 for G/A, adjusted OR = 1.81, 95%CI: 1.20-2.72, p = 0.005 for A/A, respectively), and for glioblastoma (adjusted OR = 1.51, 95%CI: 1.06-2.17, p = 0.024 and adjusted OR = 2.35, 95%CI: 1.34-4.15, p = 0.003, respectively). The A allele significantly increased glioma risk (OR = 1.31, 95%CI: 1.11-1.55, p = 0.001). The additive model (G/G vs G/A vs A/A) showed that both G/A and A/A genotype increased glioma risk (adjusted OR = 1.40, 95% CI: 1.17-1.66, p = 0.0002).G/A and A/A genotypes or EGF +61 A allele increased risk in both low and high WHO grade glioma. Non-smokers with G/A and A/A genotype showed increased glioma risk compared with G/G genotype (adjusted OR = 1.72, 95%CI: 1.29-2.30, p = 0.0002 and adjusted OR = 1.81, 95%CI: 1.10-2.99, p = 0.020, respectively). This association was not found in ever- or current-smokers. Conclusions Our study indicated that G/A and A/A genotypes or EGF +61 A allele were associated with higher glioma risk in Chinese. This is in contrast with previous studies which reported G allele as a risk factor of glioma in Caucasian. The role of EGF +61 A/G polymorphism in glioma susceptibility needs further investigation.

Underwater communication is a very challenging topic. Protocols used in terrestrial sensor networks cannot be directly applied in the underwater world. High-bit error rate and large propagation delay make the design of transport protocols especially awkward. ARQ-based reliable transport schemes are not appropriate in underwater environments due to large propagation delay, low communication bandwidth, and high error probability. Thus, we focus on redundancy-based transport schemes in this paper. We first investigate three schemes that employ redundancy mechanisms at the bit and/or packet level to increase the reliability in a direct link scenario. Then, we show that the broadcast property of the underwater channel allows us to extend those schemes to a case with node cooperative communication. Based on our analysis, an adaptive redundancy transport protocol (ARRTP) for underwater sensor networks is proposed. We suggest an architecture for implementation. For two kinds of topologies, namely, regular and random, we show that ARRTP presents a better transmission success probability and energy efficiency tradeoff for single- and multihop transmissions. We also offer an integrated case study to show that ARRTP is not only supplying reliability but also has some positive effect in guiding the deployment of underwater sensor nodes.

Radar stealth structures that can achieve high-efficiency wide-angle absorption are key components of future military equipment. However, it is difficult for both planar and three-dimensional (3D) absorbers to achieve efficient absorption in a large incidence angle range. The multilayer reconfigurable absorber component based on Miura origami provides a unique solution. First, the multilayer origami absorber is parameterized in the simulation software. Each origami structure is covered with resistive films that fit the panels. Geometric constraints are satisfied among the multilayer structures. They support reconfigurability in the range of continuous states (as opposed to discrete states), which is conducive to finding the folded state with a more efficient absorption rate within the frequency band. Secondly, the designed structure does not require a specialized mechanically supported multilayer origami absorber. In addition, the equivalent analogue circuit method is used to analyze the efficient absorption of multilayer origami under oblique incidence. Finally, our proposed absorber satisfies the requirements of multiple absorption metrics: broadband, high efficiency, wide incidence angle, and polarization insensitivity. As the validation, we simulated and fabricated a double-layer origami absorber. Our proposed origami absorber can maintain an absorption rate of more than 90% for both transverse electric (TE) and transverse magnetic (TM) polarizations in the operating frequency band (5-20 GHz) over a wide range of incidence angles (0°-70°). When the incidence angle q inc  = 40°, the double-layer origami absorber (q 1  = 90°, α 1  = 60°, and a 2  = 75°) can achieve at least 10 dB reflection reduction of -18 dB and -20 dB in TE and TM modes, respectively. The proposed origami absorber provides a reference for the design of other absorbers.