658 results on '"Byrnes, Graham"'
Search Results
102. DNA methylome analysis identifies accelerated epigenetic ageing associated with postmenopausal breast cancer susceptibility
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Epidemiology & Health Economics, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Cardiovasculaire Epi Team 3, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Ambatipudi, Srikant, Horvath, Steve, Perrier, Flavie, Cuenin, Cyrille, Hernandez-Vargas, Hector, Le Calvez-Kelm, Florence, Durand, Geoffroy, Byrnes, Graham, Ferrari, Pietro, Bouaoun, Liacine, Sklias, Athena, Chajes, Véronique, Overvad, Kim, Severi, Gianluca, Baglietto, Laura, Clavel-Chapelon, Françoise, Kaaks, Rudolf, Barrdahl, Myrto, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Masala, Giovanna, Agnoli, Claudia, Polidoro, Silvia, Tumino, Rosario, Panico, Salvatore, Dollé, Martijn, Peeters, Petra H M, Onland-Moret, N. Charlotte, Sandanger, Torkjel M., Nøst, Therese H., Weiderpass Vainio, Elisabete, Quirós, J. Ramón, Agudo, Antonio, Rodriguez-Barranco, Miguel, Huerta Castaño, José María, Barricarte, Aurelio, Fernández, Ander Matheu, Travis, Ruth C., Vineis, Paolo, Muller, David C., Riboli, Elio, Gunter, Marc, Romieu, Isabelle, Herceg, Zdenko, Epidemiology & Health Economics, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Cardiovasculaire Epi Team 3, Brain, Circulatory Health, JC onderzoeksprogramma Cardiovasculaire Epidemiologie, Ambatipudi, Srikant, Horvath, Steve, Perrier, Flavie, Cuenin, Cyrille, Hernandez-Vargas, Hector, Le Calvez-Kelm, Florence, Durand, Geoffroy, Byrnes, Graham, Ferrari, Pietro, Bouaoun, Liacine, Sklias, Athena, Chajes, Véronique, Overvad, Kim, Severi, Gianluca, Baglietto, Laura, Clavel-Chapelon, Françoise, Kaaks, Rudolf, Barrdahl, Myrto, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Naska, Androniki, Masala, Giovanna, Agnoli, Claudia, Polidoro, Silvia, Tumino, Rosario, Panico, Salvatore, Dollé, Martijn, Peeters, Petra H M, Onland-Moret, N. Charlotte, Sandanger, Torkjel M., Nøst, Therese H., Weiderpass Vainio, Elisabete, Quirós, J. Ramón, Agudo, Antonio, Rodriguez-Barranco, Miguel, Huerta Castaño, José María, Barricarte, Aurelio, Fernández, Ander Matheu, Travis, Ruth C., Vineis, Paolo, Muller, David C., Riboli, Elio, Gunter, Marc, Romieu, Isabelle, and Herceg, Zdenko
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- 2017
103. Proceedings of the 7th Biannual International Symposium on Nasopharyngeal Carcinoma 2015
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Tan, IB, Chang, Ellen T., Chen, Chien-Jen, Hsu, Wan-Lun, Chien, Yin-Chu, Hildesheim, Allan, McKay, James D., Gaborieau, Valerie, Kaderi, Mohamed Arifin Bin, Purnomosari, Dewajani, Voegele, Catherine, LeCalvez-Kelm, Florence, Byrnes, Graham, Brennan, Paul, Devi, Beena, Li, L., Zhang, Y., Fan, Y., Sun, K., Du, Z., Sun, H., Chan, A. T., Tsao, S. W., Zeng, Y. X., Tao, Q., Busson, Pierre, Lhuillier, Claire, Morales, Olivier, Mrizak, Dhafer, Gelin, Aurore, Kapetanakis, Nikiforos, Delhem, Nadira, Mansouri, Sheila, Cao, Jennifer, Vaidya, Anup, Frappier, Lori, Wai, Lo Kwok, Chen, Sui-Hong, Du, Jin-lin, Ji, Ming-Fang, Huang, Qi-Hong, Liu, Qing, Cao, Su-Mei, Doolan, Denise L., Coghill, Anna, Mulvenna, Jason, Proietti, Carla, Lekieffre, Lea, Bethony, Jeffrey, Hildesheim, and Allan, Fles, Renske, Indrasari, Sagung Rai, Herdini, Camelia, Martini, Santi, Isfandiari, Atoillah, Rhomdoni, Achmad, Adham, Marlinda, Mayangsari, Ika, van Werkhoven, Erik, Wildeman, Maarten, Hariwiyanto, Bambang, Hermani, Bambang, Kentjono, Widodo Ario, Haryana, Sofia Mubarika, Schmidt, Marjanka, O’Sullivan, Brian, Ozyar, Enis, Lee, Anne W. M., Zeng, Mu-Sheng, Gao, Xiaojiang, Tang, Minzhong, Martin, Pat, Zeng, Yi, Carrington, Mary, Coghill, Anna E., Bu, Wei, Nguyen, Hanh, Yu, Kelly J., Lou, Pei-Jen, Wang, Cheng-Ping, Cohen, Jeffrey I., King, Ann D., Chen, Tseng-Cheng, Lin, Ching-Yuan, Tsou, Yung-An, Leu, Yi-Shing, Laio, Li-Jen, Chang, Yen-Liang, Hua, Chun-Hun, Wu, Ming-Shiang, Hsiao, Chu-Hsing Kate, Lee, Jehn-Chuan, Tsai, Ming-Hsui, Cheng, Skye Hung-Chun, Liao, Li-Jen, Yang, Tsung-Lin, Ko, Jenq-Yuh, Ko, Josephine Mun Yee, Dai, Wei, Kwong, Dora, Ng, Wai Tong, Lee, Anne, Ngan, Roger Kai Cheong, Yau, Chun Chung, Tung, Stewart, Lung, Maria Li, Ji, Mingfang, Sheng, Wei, Ng, Mun Hon, Cheng, Weimin, Yu, Xia, Wu, Biaohua, Wei, Kuangrong, Zhan, Jun, Zeng, Yi Xin, Cao, Su Mei, Xia, Ningshao, Yuan, Yong, Cui, Qian, Xu, Miao, Bei, Jin-Xin, Zeng, Yi-Xin, Şahin, B, Dizman, A, Esassolak, M, İkizler, A Saran, Yıldırım, HC, Çaloğlu, M, Atalar, B, Akman, F, Demiroz, C, Atasoy, BM, Canyilmaz, E, Igdem, S, Ugurluer, G, Kütük, T, Akmansoy, M, Ozyar, E, Sommat, Kiattisa, Wang, Fu Qiang, Kwok, Li-Lian, Tan, Terence, Fong, Kam Weng, Soong, Yoke Lim, Cheah, Shie Lee, Wee, Joseph, Casanova, M, Özyar, E, Patte, C, Orbach, D, Ferrari, A, Cristine, VF, Errihani, H, Pan, J, Zhang, L, Liji, S, Grzegorzewski, K, Gore, L, Varan, A, Hutajulu, Susanna Hilda, Khuzairi, Guntara, Kusumo, Henry, Hardianti, Mardiah Suci, Taroeno-Hariadi, Kartika Widayati, Purwanto, Ibnu, Kurnianda, Johan, Messick, Troy E., Malecka, Kimberly, Tolvinski, Lois, Soldan, Samantha, Deakyne, Julianna, Song, Hui, van den Heuvel, Antonio, Gu, Baiwei, Cassel, Joel, McDonnell, Mark, Smith, Garry R., Velvadapu, Venkata, Bian, Haiyan, Zhang, Yan, Carlsen, Marianne, Chen, Shuai, Donald, Alastair, Lemmen, Christian, Reitz, Allen B., Lieberman, Paul M., Chan, King Chi, Chan, Lai Sheung, Lo, Kwok Wai, Yip, Timothy Tak Chun, Kahn, Michael, Mak, Nai Ki, Liu, Fei-Fei, Khaali, Wafa, Thariat, Juliette, Fantin, Laurence, Spirito, Flavia, Khyatti, Meriem, Driss, El Khalil Ben, Olivero, Sylvain, Maryanski, Janet, Doglio, Alain, Xia, Mengxue, Xia, Yunfei, Chang, Hui, Shaw, Rachel, Rahaju, Pudji, Wisesa, Sindhu, Taroeno-Harijadi, Kartika Widayati, Dhamiyati, Wigati, Tan, Sang-Nee, Sim, Sai-Peng, Yusuf, Muhtarum, Romdhoni, Ahmad C., K, Widodo Ario, Rantam, Fedik Abdul, Sugiyanto, Aryati, Lina, Adi-Kusumo, Fajar, Bintoro, SY, Oktriani, R., Herawati, C., Surono, A., Haryana, Sofia M., Zhong, L., Ma, B. B., Kalra, M., Ngo, M., Perna, S., Leen, A., Lapteva, N., Rooney, C. M., Gottschalk, S., Mustikaningtyas, Elida, Herawati, Sri, Romdhoni, Achmad C., Xu, Yarui, Ge, Shengxiang, Li, Fugui, Ng, M. H., Tan, Louise SY, Wong, Benjamin, Lim, C. M., Rantam, Fedik A., Madani, Deasy Z., Akbar, Nur, Permana, Agung Dinasti, Fachiroh, Jajah, Hartati, Dwi, Rahayudjati, T. Baning, Darwis, Iswandi, Anwar, Khoirul, Dwidanarti, Sri Retna, Pramana, Dominicus Wendhy, Safitri, Diah Ari, Danarti, Sri Retna Dwi, Taroeno, Suryo A, Wijaya, I., Oehadian, A., Prasetya, D., Yu, Kelly J, Rahman, Sukri, Budiman, Bestari J., Novialdi, Rahmadona, Lestari, Dewi Yuri, Yin, C., Foussadier, A., Blein, E., Chen, C., Ammour, N. Bournet, Khiatti, M., Cao, S., Marzaini, Dewi Syafriyetti Soeis, Rahayujati, Baning, Gunawan, L., Mubarika Haryana, S., Hartono, Michael, Intansari, Umi, Paramita, Dewi Kartikawati, Akbar, Akmal, Hermawan, Benny, Paramita, Dewi K., Argy, Gabriella, Sihotang, Theodora Caroline, Wahyono, Daniel Joko, Soeharso, Purnomo, Suryandari, Dwi Anita, Lisnawati, Musa, Zanil, Daker, Maelinda, Tzen, Yeo Jiun, Bakar, Norhasimah, Rahman, Asma’ Saiyidatina Aishah Abdul, Ahmad, Munirah, Chia, Yeo Tiong, Beng, Alan Khoo Soo, Sasikirana, Widyandani, Wardana, Tirta, Radifar, Muhammad, Herawati, Cita, Surono, Agus, and Çocuk Sağlığı ve Hastalıkları
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Meeting Abstracts - Abstract
A1 Hope and despair in the current treatment of nasopharyngeal cancer, IB Tan, I1 NPC international incidence and risk factors, Ellen T Chang, I2 Familial nasopharyngeal carcinoma and the use of biomarkers, Chien-Jen Chen, Wan-Lun Hsu, Yin-Chu Chien, I3 Genetic susceptibility risk factors for sporadic and familial NPC: recent findings, Allan Hildesheim, I5 Genetic and environmental risk factors for nasopharyngeal cancer in Southeast Asia, James D McKay, Valerie Gaborieau, Mohamed Arifin Bin Kaderi, Dewajani Purnomosari, Catherine Voegele, Florence LeCalvez-Kelm, Graham Byrnes, Paul Brennan, Beena Devi, I6 Characterization of the NPC methylome identifies aberrant epigenetic disruption of key signaling pathways and EBV-induced gene methylation, Li L, Zhang Y, Fan Y, Sun K, Du Z, Sun H, Chan AT, Tsao SW, Zeng YX, Tao Q, I7 Tumor exosomes and translational research in NPC, Pierre Busson, Claire Lhuillier, Olivier Morales, Dhafer Mrizak, Aurore Gelin, Nikiforos Kapetanakis, Nadira Delhem, I8 Host manipulations of the Epstein-Barr virus EBNA1 protein, Sheila Mansouri, Jennifer Cao, Anup Vaidya, and Lori Frappier, I9 Somatic genetic changes in EBV-associated nasopharyngeal carcinoma, Lo Kwok Wai, I10 Preliminary screening results for nasopharyngeal carcinoma with ELISA-based EBV antibodies in Southern China, Sui-Hong Chen, Jin-lin Du, Ming-Fang Ji, Qi-Hong Huang, Qing Liu, Su-Mei Cao, I11 EBV array platform to screen for EBV antibodies associated with NPC and other EBV-associated disorders, Denise L. Doolan, Anna Coghill, Jason Mulvenna, Carla Proietti, Lea Lekieffre, Jeffrey Bethony, and Allan Hildesheim, I12 The nasopharyngeal carcinoma awareness program in Indonesia, Renske Fles, Sagung Rai Indrasari, Camelia Herdini, Santi Martini, Atoillah Isfandiari, Achmad Rhomdoni, Marlinda Adham, Ika Mayangsari, Erik van Werkhoven, Maarten Wildeman, Bambang Hariwiyanto, Bambang Hermani, Widodo Ario Kentjono, Sofia Mubarika Haryana, Marjanka Schmidt, IB Tan, I13 Current advances and future direction in nasopharyngeal cancer management, Brian O’Sullivan, I14 Management of juvenile nasopharyngeal cancer, Enis Ozyar, I15 Global pattern of nasopharyngeal cancer: correlation of outcome with access to radiotherapy, Anne WM Lee, I16 The predictive/prognostic biomarker for nasopharyngeal carcinoma, Mu-Sheng Zeng, I17 Effect of HLA and KIR polymorphism on NPC risk, Xiaojiang Gao, Minzhong Tang, Pat Martin, Yi Zeng, Mary Carrington, I18 Exploring the Association between Potentially Neutralizing Antibodies against EBV Infection and Nasopharyngeal Carcinoma, Anna E Coghill, Wei Bu, Hanh Nguyen, Wan-Lun Hsu, Kelly J Yu, Pei-Jen Lou, Cheng-Ping Wang, Chien-Jen Chen, Allan Hildesheim, Jeffrey I Cohen, I19 Advances in MR imaging in NPC, Ann D King, O1 Epstein-Barr virus seromarkers and risk of nasopharyngeal carcinoma: the gene-environment interaction study on nasopharyngeal carcinoma in Taiwan, Yin-Chu Chien, Wan-Lun Hsu, Kelly J Yu, Tseng-Cheng Chen, Ching-Yuan Lin, Yung-An Tsou, Yi-Shing Leu, Li-Jen Laio, Yen-Liang Chang, Cheng-Ping Wang, Chun-Hun Hua, Ming-Shiang Wu, Chu-Hsing Kate Hsiao, Jehn-Chuan Lee, Ming-Hsui Tsai, Skye Hung-Chun Cheng, Pei-Jen Lou, Allan Hildesheim, Chien-Jen Chen, O2 Familial tendency and environmental co-factors of nasopharyngeal carcinoma: the gene-environment interaction study on nasopharyngeal carcinoma in Taiwan, Wan-Lun Hsu, Kelly J Yu, Yin-Chu Chien, Tseng-Cheng Chen, Ching-Yuan Lin, Yung-An Tsou, Yi-Shing Leu, Li-Jen Liao, Yen-Liang Chang, Tsung-Lin Yang, Chun-Hun Hua, Ming-ShiangWu, Chu-Hsing Kate Hsiao, Jehn-ChuanLee, Ming-Hsui Tsai, Skye Hung-Chun Cheng, Jenq-Yuh Ko, Allan Hildesheim, Chien-Jen Chen, O3 The genetic susceptibility and prognostic role of TERT-CLPTM1L and genes in DNA damage pathways in NPC, Josephine Mun Yee Ko, Wei Dai, Dora Kwong, Wai Tong Ng, Anne Lee, Roger Kai Cheong Ngan, Chun Chung Yau, Stewart Tung, Maria Li Lung, O4 Long term effects of NPC screening, Mingfang Ji, Wei Sheng, Mun Hon Ng, Weimin Cheng, Xia Yu, Biaohua Wu, Kuangrong Wei, Jun Zhan, Yi Xin Zeng, Su Mei Cao, Ningshao Xia, Yong Yuan, O5 Risk prediction of nasopharyngeal carcinoma by detecting host genetic and Epstein-Barr virus variation in saliva, Qian Cui, Miao Xu, Jin-Xin Bei, Yi-Xin Zeng, O6 Patterns of care study in Turkish nasopharyngeal cancer patients (NAZOTURK): A Turkish Radiation Oncology Association Head and Neck Cancer Working Group Study, B Şahin, A Dizman, M Esassolak, A Saran İkizler, HC Yıldırım, M Çaloğlu, B Atalar, F Akman, C Demiroz, BM Atasoy, E Canyilmaz, S Igdem, G Ugurluer, T Kütük, M Akmansoy, E Ozyar, O7 Long term outcome of intensity modulated radiotherapy in nasopharyngeal carcinoma in National Cancer Centre Singapore, Kiattisa Sommat, Fu Qiang Wang, Li-Lian Kwok, Terence Tan, Kam Weng Fong, Yoke Lim Soong, Shie Lee Cheah, Joseph Wee, O8 International phase II randomized study on the addition of docetaxel to the combination of cisplatin and 5-fluorouracil in the induction treatment for nasopharyngeal carcinoma in children and adolescents, M Casanova, E Özyar, C Patte, D Orbach, A Ferrari, VF Cristine, H Errihani, J Pan, L Zhang, S Liji, K Grzegorzewski, L Gore, A Varan, O9 Prognostic impact of metastatic status in patients with nasopharyngeal carcinoma, Susanna Hilda Hutajulu, Guntara Khuzairi, Camelia Herdini, Henry Kusumo, Mardiah Suci Hardianti, Kartika Widayati Taroeno-Hariadi, Ibnu Purwanto, Johan Kurnianda, O10 Development of small molecule inhibitors of latent Epstein-Barr virus infection for the treatment of nasopharyngeal carcinoma, Troy E. Messick, Kimberly Malecka, Lois Tolvinski, Samantha Soldan, Julianna Deakyne, Hui Song, Antonio van den Heuvel, Baiwei Gu, Joel Cassel, Mark McDonnell, Garry R Smith, Venkata Velvadapu, Haiyan Bian, Yan Zhang, Marianne Carlsen, Shuai Chen, Alastair Donald, Christian Lemmen, Allen B Reitz, Paul M Lieberman, O11 Therapeutic targeting of cancer stem-like cells using a Wnt modulator, ICG-001, enhances the treatment outcome of EBV-positive nasopharyngeal carcinoma, King Chi Chan, Lai Sheung Chan, Kwok Wai Lo, Timothy Tak Chun Yip, Roger Kai Cheong Ngan, Michael Kahn, Maria Li Lung, Nai Ki Mak, O12 Role of micro-RNA in NPC biology, Fei-Fei Liu, O13 Expansion of EBNA1- and LMP2-specific effector T lymphocytes from patients with nasopharyngeal carcinoma without enhancement of regulatory T cells, Wafa Khaali; Juliette Thariat; Laurence Fantin; Flavia Spirito; Meriem Khyatti; El Khalil Ben Driss; Sylvain Olivero; Janet Maryanski; Alain Doglio, O14 The experience of patients’ life after amifostine radiotherapy treatment (ART) for nasopharyngeal carcinoma (NPC), Mengxue Xia, Yunfei Xia, Hui Chang, Rachel Shaw, O15 Analysis of mitochondrial DNA mutation in latent membrane protein-1 positive nasopharyngeal carcinoma, Pudji Rahaju, O16 Factors influencing treatment adherence of nasopharyngeal cancer and the clinical outcomes: a hospital-based study, Mardiah Suci Hardianti, Sindhu Wisesa, Kartika Widayati Taroeno-Harijadi, Ibnu Purwanto, Bambang Hariwiyanto, Wigati Dhamiyati, Johan Kurnianda, O17 Chromosomal breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells: in relation to matrix association region/scaffold attachment region, Sang-Nee Tan, Sai-Peng Sim, O18 Expression of p53 (wild type) on nasopharyngeal carcinoma stem cell that resistant to radiotherapy, Muhtarum Yusuf, Ahmad C Romdhoni, Widodo Ario K, Fedik Abdul Rantam, O19 Mathematical model of nasopharyngeal carcinoma in cellular level, Sugiyanto, Lina Aryati, Fajar Adi-Kusumo, Mardiah Suci Hardianti, O20 Differential expression of microRNA-21 on nasopharyngeal carcinoma plasma patient, SY Bintoro, R Oktriani, C. Herawati, A Surono, Sofia M. Haryana, O21 Therapeutic targeting of an oncogenic fibroblast growth factor-FGF19, which promotes proliferation and induces EMT of carcinoma cells through activating ERK and AKT signaling, L. Zhong, L. Li, B. B. Ma, A. T. Chan, Q. Tao, O22 Resist nasopharyngeal carcinoma (NPC): next generation T cells for the adoptive immunotherapy of NPC, M. Kalra, M. Ngo, S. Perna, A. Leen, N. Lapteva, C. M. Rooney, S. Gottschalk, O23 The correlation of heat shock protein 70 expressions and staging of nasopharyngeal carcinoma, Elida Mustikaningtyas, Sri Herawati, Achmad C Romdhoni, O24 Epstein-Barr virus serological profiles of nasopharyngeal carcinoma - A tribute to Werner Henle, Mingfang Ji, YaruiXu, Weimin Cheng, ShengxiangGe, Fugui Li, M. H. Ng, O25 Targeting the apoptosis pathway using combination TLR3 agonist with anti-survivin molecule (YM-155) in nasopharyngeal carcinoma, Louise SY Tan, Benjamin Wong, CM Lim, O26 The resistance mechanism of nasopharyngeal cancer stem cells to cisplatin through expression of CD44, Hsp70, p53 (wild type), Oct-4, and ß-catenin encoded-genes, Achmad C Romdhoni, Fedik A. Rantam, Widodo Ario Kentjono, P1 Prevalence of nasopharyngeal carcinoma patients at Departement of Otorhinolaringology-Head and Neck Surgery, Dr. Hasan Sadikin general hospital, Bandung, Indonesia in 2010-2014, Deasy Z Madani, Nur Akbar, Agung Dinasti Permana, P2 Case report on pediatric nasopharyngeal carcinoma at Dr. Sardjito Hospital, Yogyakarta, Camelia Herdini, Sagung Rai Indrasari, Jajah Fachiroh, Dwi Hartati, T. Baning Rahayudjati, P3 Report on loco regionally advanced nasopharyngeal cancer patients treated with induction chemotherapy followed by concurrent chemo-radiation therapy, Iswandi Darwis, Susanna Hilda Hutajulu, Bambang Hariwiyanto, Wigati Dhamiyati, Ibnu Purwanto, Kartika Widayati Taroeno-Hariadi, Johan Kurnianda, P4 Sex and age differences in the survival of patients with nasopharyngeal carcinoma, Sindhu Wisesa, Mardiah Suci Hardianti, Susanna Hilda Hutajulu, Kartika Widayati Taroeno-Harijadi, Ibnu Purwanto, Camelia Herdini, Wigati Dhamiyati, Johan Kurnianda, P5 Impact of delayed diagnosis and delayed therapy in the treatment outcome of patients with nasopharyngeal carcinoma, Khoirul Anwar, Susanna Hilda Hutajulu, Sagung Rai Indrasari, Sri Retna Dwidanarti, Ibnu Purwanto, Kartika Widayati Taroeno-Hariadi, Johan Kurnianda, P6 Anaysis of pretreatment anemia in nasopharyngeal cancer patients undergoing neoadjuvant therapy, Dominicus Wendhy Pramana, Susanna Hilda Hutajulu, Bambang Hariwiyanto, Wigati Dhamiyati, Ibnu Purwanto, Kartika Widayati Taroeno-Hariadi, Johan Kurnianda, P7 Results of treatment with neoadjuvant cisplatin-5FU in locally advanced nasopharyngeal carcinoma: a local experience, Diah Ari Safitri, Susanna Hilda Hutajulu, Camelia Herdini, Sri Retna Dwi Danarti, Ibnu Purwanto, Kartika Widayati Taroeno-Hariadi, Johan Kurnianda, P8 Geriatrics with nasopharyngeal cancer, Suryo A Taroeno, Sindhu Wisesa, Kartika Widayati Taroeno-Hariadi, Ibnu Purwanto, Bambang Hariwiyanto, Wigati Dhamiyati, Johan Kurnianda, P9 Correlation of lymphocyte to monocyte and neutrophil to lymphocyte ratio to the response of cisplatin chemoradiotheraphy in locally advance nasopharyngeal carcinoma, I. Wijaya, A. Oehadian, D. Prasetya, P10 Prediction of nasopharyngeal carcinoma risk by Epstein-Barr virus seromarkers and environmental co-factors: the gene-environment interaction study on nasopharyngeal carcinoma in Taiwan, Wan-Lun Hsu, Yin-Chu Chien, Kelly J Yu, Cheng-Ping Wang, Ching-Yuan Lin, Yung-An Tsou, Yi-Shing Leu, Li-Jen Liao, Yen-Liang Chang191,192, Jenq-Yuh Ko, Chun-Hun Hua, Ming-Shiang Wu, Chu-Hsing Kate Hsiao, Jehn-Chuan Lee, Ming-Hsui Tsai, Skye Hung-Chun Cheng, Pei-Jen Lou, Allan Hildesheim, Chien-Jen Chen, P11 Non-viral risk factors for nasopharyngeal carcinoma in West Sumatra, Indonesia, Sukri Rahman, Bestari J. Budiman, Novialdi, Rahmadona, Dewi Yuri Lestari, P12 New prototype Vidas EBV IgA quick: performance on Chinese and Moroccan populations, C. Yin, A. Foussadier, E. Blein, C. Chen, N. Bournet Ammour, M. Khiatti, S. Cao, P13 The expression of EBV-LMP1 and VEGF as predictors and plasma EBV-DNA levels as early marker of distant metastasis after therapy in nasopharyngeal cancer, Dewi Syafriyetti Soeis Marzaini, P14 Characteristics and factors influencing subjects refusal for blood samples retrieval: lesson from NPC case control study in Yogyakarta – Indonesia, Dwi Hartati, Baning Rahayujati, Camelia Herdini, Jajah Fachiroh, P15 Expression of microRNA BART-7-3p and mRNA PTEN on blood plasma of patients with nasopharyngeal carcinoma, L. Gunawan, S. Mubarika Haryana, A. Surono, C. Herawati, P16 IgA response to native early antigen (IgA-EAext) of Epstein-Barr virus (EBV) in healthy population and nasopharyngeal carcinoma (NPC) patients: the potential for diagnosis and screening tools, Michael Hartono, Jajah Fachiroh, Umi Intansari, Dewi Kartikawati Paramita, P17 IgA responses against Epstein-Barr Virus Early Antigen (EBV-EA) peptides as potential candidates of nasopharyngeal carcinoma detection marker, Akmal Akbar, Jajah Fachiroh, Dewi Kartikawati Paramita, P18 Association between smoking habit and IgA-EBV titer among healthy individuals in Yogyakarta, Indonesia, Benny Hermawan, T Baning Rahayudjati, Dewi K Paramita, Jajah Fachiroh, P19 Epstein-Barr virus IgA titer comparison of healthy non-family individuals and healthy first degree family of NPV patients, Gabriella Argy, Jajah Fachiroh, Dewi Kartikawati Paramita, Susanna Hilda Hutajulu, P20 Identification of EBV Early Antigen (EA) derived peptides for NPC diagnosis, Theodora Caroline Sihotang, Jajah Fachiroh, Umi Intansari, Dewi Kartikawati Paramita, P21 Host-pathogen study: relative expression of mRNA BRLF1 Epstein-Barr virus as a potential biomarker for tumor progressivity and polymorphisms of TCRBC and TCRGC2 host genes related to genetic susceptibility on nasopharyngeal carcinoma, Daniel Joko Wahyono, Purnomo Soeharso, Dwi Anita Suryandari, Lisnawati, Zanil Musa, Bambang Hermani, P22 In vitro efficacy of silvestrol and episilvestrol, isolated from Borneo, on nasopharyngeal carcinoma, a major cancer in Borneo, Maelinda Daker, Yeo Jiun Tzen, Norhasimah Bakar, Asma’ Saiyidatina Aishah Abdul Rahman, Munirah Ahmad, Yeo Tiong Chia, Alan Khoo Soo Beng, P23 The expression of mir-141 in patients with nasopharyngeal cancer, Widyandani Sasikirana, Tirta Wardana, Muhammad Radifar, Cita Herawati, Agus Surono, Sofia Mubarika Haryana
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- 2016
104. Additional file 4: of Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Burton, Anya, Byrnes, Graham, Stone, Jennifer, Rulla Tamimi, Heine, John, Celine Vachon, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria, Scott, Christopher, Hipwell, John, Dickens, Caroline, SchĂźz, Joachim, Aribal, Mustafa, Bertrand, Kimberly, Kwong, Ava, Giles, Graham, Hopper, John, GĂłmez, Beatriz PĂŠrez, PollĂĄn, Marina, Soo-Hwang Teo, Shivaani Mariapun, Taib, Nur, MartĂN Lajous, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Anath Flugelman, Giske Ursin, Qureshi, Samera, Huiyan Ma, Eunjung Lee, Sirous, Reza, Mehri Sirous, Lee, Jong, Jisun Kim, Dorria Salem, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Kee-Seng Chia, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, Gils, Carla Van, Wanders, Johanna, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin, Boyd, Norman, Dos-Santos-Silva, Isabel, and McCormack, Valerie
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is Table S4 presenting mean differences in MD measures between processed images and the corresponding raw digital image, by percent density and breast area categories. (DOC 30 kb)
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- 2016
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105. Additional file 3: of MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes
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Ardin, Maude, Cahais, Vincent, Castells, Xavier, Liacine Bouaoun, Byrnes, Graham, Herceg, Zdenko, Jiri Zavadil, and Olivier, Magali
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Screenshots of MutSpec tools inputs and outputs in Galaxy. (PPT 2468Â kb)
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- 2016
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106. Additional file 1: of Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Burton, Anya, Byrnes, Graham, Stone, Jennifer, Rulla Tamimi, Heine, John, Celine Vachon, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria, Scott, Christopher, Hipwell, John, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa, Bertrand, Kimberly, Kwong, Ava, Giles, Graham, Hopper, John, Gómez, Beatriz Pérez, Pollán, Marina, Soo-Hwang Teo, Shivaani Mariapun, Taib, Nur, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Anath Flugelman, Giske Ursin, Qureshi, Samera, Huiyan Ma, Eunjung Lee, Sirous, Reza, Mehri Sirous, Lee, Jong, Jisun Kim, Dorria Salem, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Kee-Seng Chia, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, Gils, Carla Van, Wanders, Johanna, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin, Boyd, Norman, Dos-Santos-Silva, Isabel, and McCormack, Valerie
- Abstract
is Table S1 presenting percent density, dense area and total breast area in raw–processed image pairs and in SFM–processed digital image pairs, by reader. (DOC 33 kb)
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- 2016
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107. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries
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Freisling, Heinz Pisa, Pedro T. Ferrari, Pietro Byrnes, Graham Moskal, Aurelie Dahm, Christina C. Vergnaud, Anne-Claire Boutron-Ruault, Marie-Christine Fagherazzi, Guy and Cadeau, Claire Kuehn, Tilman Neamat-Allah, Jasmine Buijsse, Brian Boeing, Heiner Halkjaer, Jytte Tjonneland, Anne and Hansen, Camilla P. Ramon Quiros, J. Travier, Noemie and Molina-Montes, Esther Amiano, Pilar Huerta, Jose M. and Barricarte, Aurelio Khaw, Kay-Tee Wareham, Nicholas Key, Tim J. Romaguera, Dora Lu, Yunxia Lassale, Camille M. Naska, Androniki Orfanos, Philippos Trichopoulou, Antonia Masala, Giovanna Pala, Valeria Berrino, Franco Tumino, Rosario and Ricceri, Fulvio de Magistris, Maria Santucci Bueno-de-Mesquita, H. Bas Ocke, Marga C. Sonestedt, Emily Ericson, Ulrika and Johansson, Mattias Skeie, Guri Weiderpass, Elisabete and Braaten, Tonje Peeters, Petra H. M. Slimani, Nadia
- Abstract
Various food patterns have been associated with weight change in adults, but it is unknown which combinations of nutrients may account for such observations. We investigated associations between main nutrient patterns and prospective weight change in adults. This study includes 235,880 participants, 25-70 years old, recruited between 1992 and 2000 in 10 European countries. Intakes of 23 nutrients were estimated from country-specific validated dietary questionnaires using the harmonized EPIC Nutrient DataBase. Four nutrient patterns, explaining 67 % of the total variance of nutrient intakes, were previously identified from principal component analysis. Body weight was measured at recruitment and self-reported 5 years later. The relationship between nutrient patterns and annual weight change was examined separately for men and women using linear mixed models with random effect according to center controlling for confounders. Mean weight gain was 460 g/year (SD 950) and 420 g/year (SD 940) for men and women, respectively. The annual differences in weight gain per one SD increase in the pattern scores were as follows: principal component (PC) 1, characterized by nutrients from plant food sources, was inversely associated with weight gain in men (-22 g/year; 95 % CI -33 to -10) and women (-18 g/year; 95 % CI -26 to -11). In contrast, PC4, characterized by protein, vitamin B2, phosphorus, and calcium, was associated with a weight gain of +41 g/year (95 % CI +2 to +80) and +88 g/year (95 % CI +36 to +140) in men and women, respectively. Associations with PC2, a pattern driven by many micro-nutrients, and with PC3, a pattern driven by vitamin D, were less consistent and/or non-significant. We identified two main nutrient patterns that are associated with moderate but significant long-term differences in weight gain in adults.
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- 2016
108. Additional file 3: of Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Burton, Anya, Byrnes, Graham, Stone, Jennifer, Rulla Tamimi, Heine, John, Celine Vachon, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria, Scott, Christopher, Hipwell, John, Dickens, Caroline, SchĂźz, Joachim, Aribal, Mustafa, Bertrand, Kimberly, Kwong, Ava, Giles, Graham, Hopper, John, GĂłmez, Beatriz PĂŠrez, PollĂĄn, Marina, Soo-Hwang Teo, Shivaani Mariapun, Taib, Nur, MartĂN Lajous, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Anath Flugelman, Giske Ursin, Qureshi, Samera, Huiyan Ma, Eunjung Lee, Sirous, Reza, Mehri Sirous, Lee, Jong, Jisun Kim, Dorria Salem, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Kee-Seng Chia, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, Gils, Carla Van, Wanders, Johanna, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin, Boyd, Norman, Dos-Santos-Silva, Isabel, and McCormack, Valerie
- Abstract
is Table S3 presenting correlation of MD measures in inter-reader repeats. (DOC 29 kb)
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- 2016
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109. Additional file 7: of Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Burton, Anya, Byrnes, Graham, Stone, Jennifer, Rulla Tamimi, Heine, John, Celine Vachon, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria, Scott, Christopher, Hipwell, John, Dickens, Caroline, SchĂźz, Joachim, Aribal, Mustafa, Bertrand, Kimberly, Kwong, Ava, Giles, Graham, Hopper, John, GĂłmez, Beatriz PĂŠrez, PollĂĄn, Marina, Soo-Hwang Teo, Shivaani Mariapun, Taib, Nur, MartĂN Lajous, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Anath Flugelman, Giske Ursin, Qureshi, Samera, Huiyan Ma, Eunjung Lee, Sirous, Reza, Mehri Sirous, Lee, Jong, Jisun Kim, Dorria Salem, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Kee-Seng Chia, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, Gils, Carla Van, Wanders, Johanna, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin, Boyd, Norman, Dos-Santos-Silva, Isabel, and McCormack, Valerie
- Abstract
is Information 1 showing calibration equations for the conversion of raw vDA to processed vDA, and Information 2 showing calibration equations for the conversion of processed vDA to raw vDA. (DOC 41 kb)
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- 2016
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110. Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study
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Zamora-Ros, Raul Rinaldi, Sabina Tsilidis, Konstantinos K. and Weiderpass, Elisabete Boutron-Ruault, Marie-Christine and Rostgaard-Hansen, Agnetha Linn Tjonneland, Anne Clavel-Chapelon, Francoise Mesrine, Sylvie Katzke, Verena A. Kuehn, Tilman and Foerster, Jana Boeing, Heiner Trichopoulou, Antonia and Lagiou, Pagona Klinaki, Eleni Masala, Giovanna Sieri, Sabina and Ricceri, Fulvio Tumino, Rosario Mattiello, Amalia and Peeters, Petra H. M. Bueno-de-Mesquita, H. B(as) Engeset, Dagrun and Skeie, Guri Argueelles, Marcial Agudo, Antonio Sanchez, Maria-Jose Chirlaque, Maria-Dolores Barricarte, Aurelio and Chamosa, Saioa Almquist, Martin Tosovic, Ada Hennings, Joakim Sandstrom, Maria Schmidt, Julie A. Khaw, Kay-Thee and Wareham, Nicholas J. Cross, Amanda J. Slimani, Nadia Byrnes, Graham Romieu, Isabelle Riboli, Elio Franceschi, Silvia
- Abstract
Incidence rates of differentiated thyroid carcinoma (TC) have increased in many countries. Adiposity and dietary risk factors may play a role, but little is known on the influence of energy intake and macronutrient composition. The aim of this study was to investigate the associations between TC and the intake of energy, macronutrients, glycemic index (GI) and glycemic load in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. The study included 477,274 middle-age participants (70.2% women) from ten European countries. Dietary data were collected using country-specific validated dietary questionnaires. Total carbohydrates, proteins, fats, saturated, monounsaturated and polyunsaturated fats (PUFA), starch, sugar, and fiber were computed as g/1,000 kcal. Multivariable Cox regression was used to calculate multivariable adjusted hazard ratios (HR) and 95% confidence interval (CI) by intake quartile (Q). After a mean follow-up time of 11 years, differentiated TC was diagnosed in 556 participants (90% women). Overall, we found significant associations only with total energy (HRQ4vs.Q1, 1.29; 95% CI, 1.00-1.68) and PUFA intakes (HRQ4vs.Q1, 0.74; 95% CI, 0.57-0.95). However, the associations with starch and sugar intake and GI were significantly heterogeneous across body mass index (BMI) groups, i.e., positive associations with starch and GI were found in participants with a BMI25 and with sugar intake in those with BMI
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- 2016
111. Additional file 2: of Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Burton, Anya, Byrnes, Graham, Stone, Jennifer, Rulla Tamimi, Heine, John, Celine Vachon, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria, Scott, Christopher, Hipwell, John, Dickens, Caroline, SchĂźz, Joachim, Aribal, Mustafa, Bertrand, Kimberly, Kwong, Ava, Giles, Graham, Hopper, John, GĂłmez, Beatriz PĂŠrez, PollĂĄn, Marina, Soo-Hwang Teo, Shivaani Mariapun, Taib, Nur, MartĂN Lajous, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Anath Flugelman, Giske Ursin, Qureshi, Samera, Huiyan Ma, Eunjung Lee, Sirous, Reza, Mehri Sirous, Lee, Jong, Jisun Kim, Dorria Salem, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Kee-Seng Chia, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, Gils, Carla Van, Wanders, Johanna, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin, Boyd, Norman, Dos-Santos-Silva, Isabel, and McCormack, Valerie
- Abstract
is Table S2 presenting mean MD measures of inter-reader repeats, by reader and image type. (DOC 29 kb)
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- 2016
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112. Additional file 2: of MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes
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Ardin, Maude, Cahais, Vincent, Castells, Xavier, Liacine Bouaoun, Byrnes, Graham, Herceg, Zdenko, Jiri Zavadil, and Olivier, Magali
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Example of NMF analysis with combined matrices from different analyses. Matrices from two different analyses may be combined in a single matrix to analyse samples from analysis 1 and 2 together. This matrix should contain a header with sample IDs and have 96 rows describing the 6 SBS types in their sequence context. The matrix should be formatted as tab-delimited text to be accepted as input of MutSpec-NMF. (PPT 348Â kb)
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- 2016
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113. Additional file 6: of Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Burton, Anya, Byrnes, Graham, Stone, Jennifer, Rulla Tamimi, Heine, John, Celine Vachon, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria, Scott, Christopher, Hipwell, John, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa, Bertrand, Kimberly, Kwong, Ava, Giles, Graham, Hopper, John, Gómez, Beatriz Pérez, Pollán, Marina, Soo-Hwang Teo, Shivaani Mariapun, Taib, Nur, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Anath Flugelman, Giske Ursin, Qureshi, Samera, Huiyan Ma, Eunjung Lee, Sirous, Reza, Mehri Sirous, Lee, Jong, Jisun Kim, Dorria Salem, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Kee-Seng Chia, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, Gils, Carla Van, Wanders, Johanna, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin, Boyd, Norman, Dos-Santos-Silva, Isabel, and McCormack, Valerie
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is Figure S2 showing Bland–Altman plots for within-system and within-reader standardized vDA measures. (DOCX 79 kb)
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- 2016
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114. Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer
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Fernandez-Cuesta, Lynnette Perdomo, Sandra Avogbe, Patrice H. and Leblay, Noemie Delhomme, Tiffany M. Gaborieau, Valerie and Abedi-Ardekani, Behnoush Chanudet, Estelle Olivier, Magali and Zaridze, David Mukeria, Anush Vilensky, Marta Holcatova, Ivana Polesel, Jerry Simonato, Lorenzo Canova, Cristina and Lagiou, Pagona Brambilla, Christian Brambilla, Elisabeth and Byrnes, Graham Scelo, Ghislaine Le Calvez-Kelm, Florence and Foll, Matthieu McKay, James D. Brennan, Paul
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neoplasms - Abstract
Circulating tumor DNA (ctDNA) is emerging as a key potential biomarker for post-diagnosis surveillance but it may also play a crucial role in the detection of pre-clinical cancer. Small-cell lung cancer (SCLC) is an excellent candidate for early detection given there are no successful therapeutic options for late-stage disease, and it displays almost universal inactivation of TP53. We assessed the presence of TP53 mutations in the cell-free DNA (cfDNA) extracted from the plasma of 51 SCLC cases and 123 non-cancer controls. We identified mutations using a pipeline specifically designed to accurately detect variants at very low fractions. We detected TP53 mutations in the cfDNA of 49% SCLC patients and 11.4% of non-cancer controls. When stratifying the 51 initial SCLC cases by stage, TP53 mutations were detected in the cfDNA of 35.7% early-stage and 54.1% late-stage SCLC patients. The results in the controls were further replicated in 10.8% of an independent series of 102 non-cancer controls. The detection of TP53 mutations in 11% of the 225 non-cancer controls suggests that somatic mutations in cfDNA among individuals without any cancer diagnosis is a common occurrence, and poses serious challenges for the development of ctDNA screening tests. (C) 2016 Published by Elsevier B.V.
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- 2016
115. Additional file 5: of Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Burton, Anya, Byrnes, Graham, Stone, Jennifer, Rulla Tamimi, Heine, John, Celine Vachon, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria, Scott, Christopher, Hipwell, John, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa, Bertrand, Kimberly, Kwong, Ava, Giles, Graham, Hopper, John, Gómez, Beatriz Pérez, Pollán, Marina, Soo-Hwang Teo, Shivaani Mariapun, Taib, Nur, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Anath Flugelman, Giske Ursin, Qureshi, Samera, Huiyan Ma, Eunjung Lee, Sirous, Reza, Mehri Sirous, Lee, Jong, Jisun Kim, Dorria Salem, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Kee-Seng Chia, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, Gils, Carla Van, Wanders, Johanna, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin, Boyd, Norman, Dos-Santos-Silva, Isabel, and McCormack, Valerie
- Abstract
is Figure S1 showing Bland–Altman plots for vMD measures, by mammography system and reader for: (A) percent mammographic density, (B) dense area and (C) breast area. Y axes to the same scale for comparisons. (DOCX 138 kb)
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- 2016
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116. Investigation of DNA repair-related SNPs underlying susceptibility to papillary thyroid carcinoma reveals MGMT as a novel candidate gene in Belarusian children exposed to radiation
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Lonjou, Christine, primary, Damiola, Francesca, additional, Moissonnier, Monika, additional, Durand, Geoffroy, additional, Malakhova, Irina, additional, Masyakin, Vladimir, additional, Le Calvez-Kelm, Florence, additional, Cardis, Elisabeth, additional, Byrnes, Graham, additional, Kesminiene, Ausrele, additional, and Lesueur, Fabienne, additional
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- 2017
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117. Unique DNA methylation signature in HPV-positive head and neck squamous cell carcinomas
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Degli Esposti, Davide, primary, Sklias, Athena, additional, Lima, Sheila C., additional, Beghelli-de la Forest Divonne, Stéphanie, additional, Cahais, Vincent, additional, Fernandez-Jimenez, Nora, additional, Cros, Marie-Pierre, additional, Ecsedi, Szilvia, additional, Cuenin, Cyrille, additional, Bouaoun, Liacine, additional, Byrnes, Graham, additional, Accardi, Rosita, additional, Sudaka, Anne, additional, Giordanengo, Valérie, additional, Hernandez-Vargas, Hector, additional, Pinto, Luis Felipe Ribeiro, additional, Van Obberghen-Schilling, Ellen, additional, and Herceg, Zdenko, additional
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- 2017
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118. Correction: Corrigendum: Modelling mutational landscapes of human cancers in vitro
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Olivier, Magali, primary, Weninger, Annette, additional, Ardin, Maude, additional, Huskova, Hana, additional, Castells, Xavier, additional, Vallée, Maxime P., additional, McKay, James, additional, Nedelko, Tatiana, additional, Muehlbauer, Karl-Rudolf, additional, Marusawa, Hiroyuki, additional, Alexander, John, additional, Hazelwood, Lee, additional, Byrnes, Graham, additional, Hollstein, Monica, additional, and Zavadil, Jiri, additional
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- 2017
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119. Risks for Relatives
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Hopper, John L, primary, Dite, Gillian S, additional, and Byrnes, Graham B, additional
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- 2017
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120. MA11.05 A Case-Control Study to Test the Use of ctDNA in the Early Detection of SCLC Reveals TP53 Mutations in Non-Cancer Controls
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Fernandez-Cuesta, Lynnette, primary, Perdomo, Sandra, additional, Avogbe, Patrice, additional, Leblay, Noémie, additional, Delhomme, Tiffany, additional, Gaborieau, Valerie, additional, Abedi-Ardekani, Behnoush, additional, Chanudet, Estelle, additional, Olivier, Magali, additional, Zaridze, David, additional, Mukeria, Anush, additional, Vilensky, Marta, additional, Holcatova, Ivana, additional, Polesel, Jerry, additional, Simonato, Lorenzo, additional, Canova, Cristina, additional, Lagiou, Pagona, additional, Brambilla, Christian, additional, Brambilla, Elisabeth, additional, Byrnes, Graham, additional, Scelo, Ghislaine, additional, Le Calvez-Kelm, Florence, additional, Foll, Matthieu, additional, Mckay, James, additional, and Brennan, Paul, additional
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- 2017
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121. P3.03-015 BAP1 is Inactivated by Copy Number Loss, Mutation, and/or Loss of Expression in More Than 70% Malignant Peritoneal Mesotheliomas
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Leblay, Noémie, primary, Leprêtre, Frédéric, additional, Le Stang, Nolwenn, additional, Gautier-Stein, Amandine, additional, Villeneuve, Laurent, additional, Isaac, Sylvie, additional, Maillet, Denis, additional, Galateau-Sallé, Françoise, additional, Villenet, Céline, additional, Sebda, Shéhérazade, additional, Byrnes, Graham, additional, Mckay, James, additional, Figeac, Martin, additional, Glehen, Olivier, additional, Gilly, François-Noël, additional, Foll, Matthieu, additional, Fernandez-Cuesta, Lynnette, additional, and Brevet, Marie, additional
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- 2017
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122. Inflammatory Cytokines and Lung Cancer Risk in 3 Prospective Studies
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Brenner, Darren R., primary, Fanidi, Anouar, additional, Grankvist, Kjell, additional, Muller, David C., additional, Brennan, Paul, additional, Manjer, Jonas, additional, Byrnes, Graham, additional, Hodge, Allison, additional, Severi, Gianluca, additional, Giles, Graham G., additional, Johansson, Mikael, additional, and Johansson, Mattias, additional
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- 2016
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123. Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Burton, Anya, primary, Byrnes, Graham, additional, Stone, Jennifer, additional, Tamimi, Rulla M., additional, Heine, John, additional, Vachon, Celine, additional, Ozmen, Vahit, additional, Pereira, Ana, additional, Garmendia, Maria Luisa, additional, Scott, Christopher, additional, Hipwell, John H., additional, Dickens, Caroline, additional, Schüz, Joachim, additional, Aribal, Mustafa Erkin, additional, Bertrand, Kimberly, additional, Kwong, Ava, additional, Giles, Graham G., additional, Hopper, John, additional, Pérez Gómez, Beatriz, additional, Pollán, Marina, additional, Teo, Soo-Hwang, additional, Mariapun, Shivaani, additional, Taib, Nur Aishah Mohd, additional, Lajous, Martín, additional, Lopez-Riduara, Ruy, additional, Rice, Megan, additional, Romieu, Isabelle, additional, Flugelman, Anath Arzee, additional, Ursin, Giske, additional, Qureshi, Samera, additional, Ma, Huiyan, additional, Lee, Eunjung, additional, Sirous, Reza, additional, Sirous, Mehri, additional, Lee, Jong Won, additional, Kim, Jisun, additional, Salem, Dorria, additional, Kamal, Rasha, additional, Hartman, Mikael, additional, Miao, Hui, additional, Chia, Kee-Seng, additional, Nagata, Chisato, additional, Vinayak, Sudhir, additional, Ndumia, Rose, additional, van Gils, Carla H., additional, Wanders, Johanna O. P., additional, Peplonska, Beata, additional, Bukowska, Agnieszka, additional, Allen, Steve, additional, Vinnicombe, Sarah, additional, Moss, Sue, additional, Chiarelli, Anna M., additional, Linton, Linda, additional, Maskarinec, Gertraud, additional, Yaffe, Martin J., additional, Boyd, Norman F., additional, dos-Santos-Silva, Isabel, additional, and McCormack, Valerie A., additional
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- 2016
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124. A statistical framework to model the meeting-in-the-middle principle using metabolomic data: application to hepatocellular carcinoma in the EPIC study
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Assi, Nada Fages, Anne Vineis, Paolo Chadeau-Hyam, Marc and Stepien, Magdalena Duarte-Salles, Talita Byrnes, Graham and Boumaza, Houda Knueppel, Sven Kuehn, Tilman Palli, Domenico and Bamia, Christina Boshuizen, Hendriek Bonet, Catalina and Overvad, Kim Johansson, Mattias Travis, Ruth Gunter, Marc J. and Lund, Eiliv Dossus, Laure Elena-Herrmann, Benedicte and Riboli, Elio Jenab, Mazda Viallon, Vivian Ferrari, Pietro
- Abstract
Metabolomics is a potentially powerful tool for identification of biomarkers associated with lifestyle exposures and risk of various diseases. This is the rationale of the ‘meeting-in-the-middle’ concept, for which an analytical framework was developed in this study. In a nested case-control study on hepatocellular carcinoma (HCC) within the European Prospective Investigation into Cancer and nutrition (EPIC), serum H-1 nuclear magnetic resonance (NMR) spectra (800 MHz) were acquired for 114 cases and 222 matched controls. Through partial least square (PLS) analysis, 21 lifestyle variables (the ‘predictors’, including information on diet, anthropometry and clinical characteristics) were linked to a set of 285 metabolic variables (the ‘responses’). The three resulting scores were related to HCC risk by means of conditional logistic regressions. The first PLS factor was not associated with HCC risk. The second PLS metabolomic factor was positively associated with tyrosine and glucose, and was related to a significantly increased HCC risk with OR = 1.11 (95% CI: 1.02, 1.22, P = 0.02) for a 1SD change in the responses score, and a similar association was found for the corresponding lifestyle component of the factor. The third PLS lifestyle factor was associated with lifetime alcohol consumption, hepatitis and smoking, and had negative loadings on vegetables intake. Its metabolomic counterpart displayed positive loadings on ethanol, glutamate and phenylalanine. These factors were positively and statistically significantly associated with HCC risk, with 1.37 (1.05, 1.79, P = 0.02) and 1.22 (1.04, 1.44, P = 0.01), respectively. Evidence of mediation was found in both the second and third PLS factors, where the metabolomic signals mediated the relation between the lifestyle component and HCC outcome. This study devised a way to bridge lifestyle variables to HCC risk through NMR metabolomics data. This implementation of the ‘meeting-in-the-middle’ approach finds natural applications in settings characterised by high-dimensional data, increasingly frequent in the omics generation.
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- 2015
125. The 12p13.33/RAD52 Locus and Genetic Susceptibility to Squamous Cell Cancers of Upper Aerodigestive Tract
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Delahaye-Sourdeix, Manon Oliver, Javier Timofeeva, Maria N. and Gaborieau, Valerie Johansson, Mattias Chabrier, Amelie and Wozniak, Magdalena B. Brenner, Darren R. Vallee, Maxime P. and Anantharaman, Devasena Lagiou, Pagona Holcatova, Ivana and Richiardi, Lorenzo Kjaerheim, Kristina Agudo, Antonio and Castellsague, Xavier Macfarlane, Tatiana V. Barzan, Luigi and Canova, Cristina Thakker, Nalin S. Conway, David I. Znaor, Ariana Healy, Claire M. Ahrens, Wolfgang Zaridze, David and Szeszenia-Dabrowska, Neonilia Lissowska, Jolanta Fabianova, Eleonora Mates, Ioan Nicolae Bencko, Vladimir Foretova, Lenka Janout, Vladimir Curado, Maria Paula Koifman, Sergio and Menezes, Ana Wuensch-Filho, Victor Eluf-Neto, Jose and Boffetta, Paolo Fernandez Garrote, Leticia Serraino, Diego and Lener, Marcin Jaworowska, Ewa Lubinski, Jan Boccia, Stefania and Rajkumar, Thangarajan Samant, Tanuja A. Mahimkar, Manoj B. and Matsuo, Keitaro Franceschi, Silvia Byrnes, Graham and Brennan, Paul McKay, James D.
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enzymes and coenzymes (carbohydrates) ,fungi ,genetic processes - Abstract
Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
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- 2015
126. Welding fumes and lung cancer: a meta-analysis of case-control and cohort studies.
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Kumar Honaryar, Manoj, Lunn, Ruth M., Luce, Danièle, Ahrens, Wolfgang, 't Mannetje, Andrea, Hansen, Johnni, Bouaoun, Liacine, Loomis, Dana, Byrnes, Graham, Vilahur, Nadia, Stayner, Leslie, Guha, Neela, and Honaryar, Manoj Kumar
- Abstract
Background: An estimated 110 million workers are exposed to welding fumes worldwide. Welding fumes are classified by the International Agency for Research on Cancer as carcinogenic to humans (group 1), based on sufficient evidence of lung cancer from epidemiological studies.Objective: To conduct a meta-analysis of case-control and cohort studies on welding or exposure to welding fumes and risk of lung cancer, accounting for confounding by exposure to asbestos and tobacco smoking.Methods: The literature was searched comprehensively in PubMed, reference lists of relevant publications and additional databases. Overlapping populations were removed. Meta-relative risks (mRRs) were calculated using random effects models. Publication bias was assessed using funnel plot, Eggers's test and Begg's test.Results: Forty-five studies met the inclusion criteria (20 case-control, 25 cohort/nested case-control), which reduced to 37 when overlapping study populations were removed. For 'ever' compared with 'never' being a welder or exposed to welding fumes, mRRs and 95% CIs were 1.29 (1.20 to 1.39; I2=26.4%; 22 studies) for cohort studies, 1.87 (1.53 to 2.29; I2=44.1%; 15 studies) for case-control studies and 1.17 (1.04 to 1.38; I2=41.2%) for 8 case-control studies that adjusted for smoking and asbestos exposure. The mRRs were 1.32 (95% CI 1.20 to 1.45; I2=6.3%; 15 studies) among 'shipyard welders', 1.44 (95% CI 1.07 to 1.95; I2=35.8%; 3 studies) for 'mild steel welders' and 1.38 (95% CI 0.89 to 2.13; I2=68.1%; 5 studies) among 'stainless steel welders'. Increased risks persisted regardless of time period, geographic location, study design, occupational setting, exposure assessment method and histological subtype.Conclusions: These results support the conclusion that exposure to welding fumes increases the risk of lung cancer, regardless of the type of steel welded, the welding method (arc vs gas welding) and independent of exposure to asbestos or tobacco smoking. [ABSTRACT FROM AUTHOR]- Published
- 2019
- Full Text
- View/download PDF
127. Molecular features of premenopausal breast cancers in Latin American women: Pilot results from the PRECAMA study.
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Olivier, Magali, Bouaoun, Liacine, Villar, Stephanie, Robitaille, Alexis, Cahais, Vincent, Heguy, Adriana, Byrnes, Graham, Le Calvez-Kelm, Florence, Torres-Mejía, Gabriela, Alvarado-Cabrero, Isabel, Imani-Razavi, Fazlollah Shahram, Inés Sánchez, Gloria, Jaramillo, Roberto, Porras, Carolina, Rodriguez, Ana Cecilia, Garmendia, Maria Luisa, Soto, José Luis, Romieu, Isabelle, Porter, Peggy, and Guenthoer, Jamie
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PERIMENOPAUSE ,BREAST cancer treatment ,CANCER in women ,LATIN American women ,IMMUNOHISTOCHEMISTRY - Abstract
Background: In Latin America (LA), there is a high incidence rate of breast cancer (BC) in premenopausal women, and the genomic features of these BC remain unknown. Here, we aim to characterize the molecular features of BC in young LA women within the framework of the PRECAMA study, a multicenter population-based case–control study of BC in premenopausal women. Methods: Pathological tumor tissues were collected from incident cases from four LA countries. Immunohistochemistry (IHC) was performed centrally for ER, PR, HER2, Ki67, EGFR, CK5/6, and p53 protein markers. Targeted deep sequencing was done on genomic DNA extracted from formalin-fixed, paraffin-embedded tumor tissues and their paired blood samples to screen for somatic mutations in eight genes frequently mutated in BC. A subset of samples was analyzed by exome sequencing to identify somatic mutational signatures. Results: The majority of cases were positive for ER or PR (168/233; 72%), and 21% were triple-negative (TN), mainly of basal type. Most tumors were positive for Ki67 (189/233; 81%). In 126 sequenced cases, TP53 and PIK3CA were the most frequently mutated genes (32.5% and 21.4%, respectively), followed by AKT1 (9.5%). TP53 mutations were more frequent in HER2-enriched and TN IHC subtypes, whereas PIK3CA/AKT1 mutations were more frequent in ER-positive tumors, as expected. Interestingly, a higher proportion of G:C>T:A mutations was observed in TP53 in PRECAMA cases compared with TCGA and METABRIC BC series (27% vs 14%). Exome-wide mutational patterns in 10 TN cases revealed alterations in signal transduction pathways and major contributions of mutational signatures caused by altered DNA repair pathways. Conclusions: These pilot results on PRECAMA tumors give a preview of the molecular features of premenopausal BC in LA. Although the overall mutation burden was as expected from data in other populations, mutational patterns observed in TP53 and exome-wide suggested possible differences in mutagenic processes giving rise to these tumors compared with other populations. Further -omics analyses of a larger number of cases in the near future will enable the investigation of relationships between these molecular features and risk factors. [ABSTRACT FROM AUTHOR]
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- 2019
- Full Text
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128. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study
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Moskal, Aurelie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjonneland, Anne, Petersen, Kristina E. N., Dahm, Christina C., Plambeck Hansen, Camilla, Affret, Aurelie, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Kuhn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-De-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Huerta Castano, Jose M., Quiros, Jose R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay-Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., Slimani, Nadia, Moskal, Aurelie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjonneland, Anne, Petersen, Kristina E. N., Dahm, Christina C., Plambeck Hansen, Camilla, Affret, Aurelie, Boutron-Ruault, Marie-Christine, Cadeau, Claire, Kuhn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-De-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Huerta Castano, Jose M., Quiros, Jose R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay-Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., and Slimani, Nadia
- Abstract
Background: Much of the current literature on diet-colorectal cancer (CRC) associations focused on studies of single foods/nutrients, whereas less is known about nutrient patterns. We investigated the association between major nutrient patterns and CRC risk in participants of the European Prospective Investigation into Cancer and Nutrition (EPIC) study. Methods: Among 477 312 participants, intakes of 23 nutrients were estimated from validated dietary questionnaires. Using results from a previous principal component (PC) analysis, four major nutrient patterns were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were computed for the association of each of the four patterns and CRC incidence using multivariate Cox proportional hazards models with adjustment for established CRC risk factors. Results: During an average of 11 years of follow-up, 4517 incident cases of CRC were documented. A nutrient pattern characterised by high intakes of vitamins and minerals was inversely associated with CRC (HR per 1 s.d. = 0.94, 95% CI: 0.92-0.98) as was a pattern characterised by total protein, riboflavin, phosphorus and calcium (HR (1 s.d.) = 0.96, 95% CI: 0.93-0.99). The remaining two patterns were not significantly associated with CRC risk. Conclusions: Analysing nutrient patterns may improve our understanding of how groups of nutrients relate to CRC.
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- 2016
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129. Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Burton, Anya, Byrnes, Graham, Stone, Jennifer, Tamimi, Rulla M, Heine, John, Vachon, Celine, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria Luisa, Scott, Christopher, Hipwell, John H, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa Erkin, Bertrand, Kimberly, Kwong, Ava, Giles, Graham G, Hopper, John, Pérez Gómez, Beatriz, Pollán, Marina, Teo, Soo-Hwang, Mariapun, Shivaani, Taib, Nur Aishah Mohd, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Flugelman, Anath Arzee, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, Sirous, Reza, Sirous, Mehri, Lee, Jong Won, Kim, Jisun, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Chia, Kee-Seng, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, van Gils, Carla H, Wanders, Johanna O P, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna M, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin J, Boyd, Norman F, Dos-Santos-Silva, Isabel, McCormack, Valerie A, Burton, Anya, Byrnes, Graham, Stone, Jennifer, Tamimi, Rulla M, Heine, John, Vachon, Celine, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria Luisa, Scott, Christopher, Hipwell, John H, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa Erkin, Bertrand, Kimberly, Kwong, Ava, Giles, Graham G, Hopper, John, Pérez Gómez, Beatriz, Pollán, Marina, Teo, Soo-Hwang, Mariapun, Shivaani, Taib, Nur Aishah Mohd, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Flugelman, Anath Arzee, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, Sirous, Reza, Sirous, Mehri, Lee, Jong Won, Kim, Jisun, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Chia, Kee-Seng, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, van Gils, Carla H, Wanders, Johanna O P, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna M, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin J, Boyd, Norman F, Dos-Santos-Silva, Isabel, and McCormack, Valerie A
- Published
- 2016
130. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study
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Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Moskal, Aurélie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjønneland, Anne, Petersen, Kristina EN, Dahm, Christina C., Hansen, Camilla Plambeck, Affret, Aurélie, Boutron-Ruault, Marie Christine, Cadeau, Claire, Kühn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-de-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Castaño, José M Huerta, Quirós, José R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., Slimani, Nadia, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Moskal, Aurélie, Freisling, Heinz, Byrnes, Graham, Assi, Nada, Fahey, Michael T., Jenab, Mazda, Ferrari, Pietro, Tjønneland, Anne, Petersen, Kristina EN, Dahm, Christina C., Hansen, Camilla Plambeck, Affret, Aurélie, Boutron-Ruault, Marie Christine, Cadeau, Claire, Kühn, Tilman, Katzke, Verena, Iqbal, Khalid, Boeing, Heiner, Trichopoulou, Antonia, Bamia, Christina, Naska, Androniki, Masala, Giovanna, de Magistris, Maria Santucci, Sieri, Sabina, Tumino, Rosario, Sacerdote, Carlotta, Peeters, Petra H., Bueno-de-Mesquita, Bas H., Engeset, Dagrun, Licaj, Idlir, Skeie, Guri, Ardanaz, Eva, Buckland, Genevieve, Castaño, José M Huerta, Quirós, José R., Amiano, Pilar, Molina-Portillo, Elena, Winkvist, Anna, Myte, Robin, Ericson, Ulrika, Sonestedt, Emily, Perez-Cornago, Aurora, Wareham, Nick, Khaw, Kay Tee, Huybrechts, Inge, Tsilidis, Konstantinos K., Ward, Heather, Gunter, Marc J., and Slimani, Nadia
- Published
- 2016
131. Main nutrient patterns are associated with prospective weight change in adults from 10 European countries
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Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Freisling, Heinz, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C., Vergnaud, Anne Claire, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P., Quirós, J. Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M., Barricarte, Aurelio, Khaw, Kay Tee, Wareham, Nicholas, Key, Tim J., Romaguera, Dora, Lu, Yunxia, Lassale, Camille M., Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra H M, Slimani, Nadia, Infection & Immunity, Cancer, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Freisling, Heinz, Pisa, Pedro T., Ferrari, Pietro, Byrnes, Graham, Moskal, Aurelie, Dahm, Christina C., Vergnaud, Anne Claire, Boutron-Ruault, Marie Christine, Fagherazzi, Guy, Cadeau, Claire, Kühn, Tilman, Neamat-Allah, Jasmine, Buijsse, Brian, Boeing, Heiner, Halkjær, Jytte, Tjonneland, Anne, Hansen, Camilla P., Quirós, J. Ramón, Travier, Noémie, Molina-Montes, Esther, Amiano, Pilar, Huerta, José M., Barricarte, Aurelio, Khaw, Kay Tee, Wareham, Nicholas, Key, Tim J., Romaguera, Dora, Lu, Yunxia, Lassale, Camille M., Naska, Androniki, Orfanos, Philippos, Trichopoulou, Antonia, Masala, Giovanna, Pala, Valeria, Berrino, Franco, Tumino, Rosario, Ricceri, Fulvio, de Magistris, Maria Santucci, Bueno-de-Mesquita, H. Bas, Ocké, Marga C., Sonestedt, Emily, Ericson, Ulrika, Johansson, Mattias, Skeie, Guri, Weiderpass, Elisabete, Braaten, Tonje, Peeters, Petra H M, and Slimani, Nadia
- Published
- 2016
132. Mammographic density assessed on paired raw and processed digital images and on paired screen-film and digital images across three mammography systems
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Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Burton, Anya, Byrnes, Graham, Stone, Jennifer, Tamimi, Rulla M, Heine, John, Vachon, Celine, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria Luisa, Scott, Christopher, Hipwell, John H, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa Erkin, Bertrand, Kimberly, Kwong, Ava, Giles, Graham G, Hopper, John, Pérez Gómez, Beatriz, Pollán, Marina, Teo, Soo-Hwang, Mariapun, Shivaani, Taib, Nur Aishah Mohd, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Flugelman, Anath Arzee, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, Sirous, Reza, Sirous, Mehri, Lee, Jong Won, Kim, Jisun, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Chia, Kee-Seng, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, van Gils, Carla H, Wanders, Johanna O P, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna M, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin J, Boyd, Norman F, Dos-Santos-Silva, Isabel, McCormack, Valerie A, Epi Kanker Team A, Cancer, JC onderzoeksprogramma Kanker, Burton, Anya, Byrnes, Graham, Stone, Jennifer, Tamimi, Rulla M, Heine, John, Vachon, Celine, Ozmen, Vahit, Pereira, Ana, Garmendia, Maria Luisa, Scott, Christopher, Hipwell, John H, Dickens, Caroline, Schüz, Joachim, Aribal, Mustafa Erkin, Bertrand, Kimberly, Kwong, Ava, Giles, Graham G, Hopper, John, Pérez Gómez, Beatriz, Pollán, Marina, Teo, Soo-Hwang, Mariapun, Shivaani, Taib, Nur Aishah Mohd, Lajous, Martín, Lopez-Riduara, Ruy, Rice, Megan, Romieu, Isabelle, Flugelman, Anath Arzee, Ursin, Giske, Qureshi, Samera, Ma, Huiyan, Lee, Eunjung, Sirous, Reza, Sirous, Mehri, Lee, Jong Won, Kim, Jisun, Salem, Dorria, Kamal, Rasha, Hartman, Mikael, Miao, Hui, Chia, Kee-Seng, Nagata, Chisato, Vinayak, Sudhir, Ndumia, Rose, van Gils, Carla H, Wanders, Johanna O P, Peplonska, Beata, Bukowska, Agnieszka, Allen, Steve, Vinnicombe, Sarah, Moss, Sue, Chiarelli, Anna M, Linton, Linda, Maskarinec, Gertraud, Yaffe, Martin J, Boyd, Norman F, Dos-Santos-Silva, Isabel, and McCormack, Valerie A
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- 2016
133. Energy and macronutrient intake and risk of differentiated thyroid carcinoma in the European Prospective Investigation into Cancer and Nutrition study
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Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Zamora-Ros, Raul, Rinaldi, Sabina, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Boutron-Ruault, Marie Christine, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Katzke, Verena A., Kühn, Tilman, Förster, Jana, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H M, Bueno-De-Mesquita, H. B., Engeset, Dagrun, Skeie, Guri, Argüelles, Marcial, Agudo, Antonio, Sánchez, María José, Chirlaque, María Dolores, Barricarte, Aurelio, Chamosa, Saioa, Almquist, Martin, Tosovic, Ada, Hennings, Joakim, Sandström, Maria, Schmidt, Julie A., Khaw, Kay Thee, Wareham, Nicholas J., Cross, Amanda J., Slimani, Nadia, Byrnes, Graham, Romieu, Isabelle, Riboli, Elio, Franceschi, Silvia, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, MS MDL 1, Infection & Immunity, Zamora-Ros, Raul, Rinaldi, Sabina, Tsilidis, Konstantinos K., Weiderpass, Elisabete, Boutron-Ruault, Marie Christine, Rostgaard-Hansen, Agnetha Linn, Tjønneland, Anne, Clavel-Chapelon, Françoise, Mesrine, Sylvie, Katzke, Verena A., Kühn, Tilman, Förster, Jana, Boeing, Heiner, Trichopoulou, Antonia, Lagiou, Pagona, Klinaki, Eleni, Masala, Giovanna, Sieri, Sabina, Ricceri, Fulvio, Tumino, Rosario, Mattiello, Amalia, Peeters, Petra H M, Bueno-De-Mesquita, H. B., Engeset, Dagrun, Skeie, Guri, Argüelles, Marcial, Agudo, Antonio, Sánchez, María José, Chirlaque, María Dolores, Barricarte, Aurelio, Chamosa, Saioa, Almquist, Martin, Tosovic, Ada, Hennings, Joakim, Sandström, Maria, Schmidt, Julie A., Khaw, Kay Thee, Wareham, Nicholas J., Cross, Amanda J., Slimani, Nadia, Byrnes, Graham, Romieu, Isabelle, Riboli, Elio, and Franceschi, Silvia
- Published
- 2016
134. Influenza Vaccine for Healthy Working Adults
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Nichol, Kristin L., Byrnes, Graham B., Kelly, Heath, Muennig, Peter, Chu, Susan Y., Singleton, James A., McCauley, Mary Mason, Orenstein, Walter A., Hughes, James M., Mawle, Alison C., Modlin, John F., Bridges, Carolyn Buxton, Meltzer, Martin I., and Thompson, William W.
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Influenza vaccines -- Economic aspects - Published
- 2001
135. Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: the EPIC study
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Zamora-Ros, Raul, Rinaldi, Sabina, Biessy, Carine, Tjonneland, Anne, Halkjaer, Jytte, Fournier, Agnes, Boutron-Ruault, Marie-Christine, Mesrine, Sylvie, Tikk, Kaja, Fortner, Renee T., Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Papatesta, Eleni-Maria, Masala, Giovanna, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Polidoro, Silvia, Peeters, Petra H. M., Bueno-de-Mesquita, H. B(as), Weiderpass, Elisabete, Lund, Eiliv, Argueelles, Marcial, Agudo, Antonio, Molina-Montes, Esther, Navarro, Carmen, Barricarte, Aurelio, Larranaga, Nerea, Manjer, Jonas, Almquist, Martin, Sandstrom, Maria, Hennings, Joakim, Tsilidis, Konstantinos K., Schmidt, Julie A., Khaw, Kay-Thee, Wareham, Nicholas J., Romieu, Isabelle, Byrnes, Graham, Gunter, Marc J., Riboli, Elio, and Franceschi, Silvia
- Subjects
HORMONAL FACTORS ,Adult ,Male ,CANCER-RISK ,VARIANTS ,Contraceptives, Oral, Hormonal ,POOLED ANALYSIS ,REPLACEMENT THERAPY ,Young Adult ,Pregnancy ,Risk Factors ,Journal Article ,Humans ,COHORT ,hormone use ,Prospective Studies ,Thyroid Neoplasms ,menstrual factors ,differentiated thyroid carcinoma ,Life Style ,Reproductive History ,METAANALYSIS ,Research Support, Non-U.S. Gov't ,Incidence ,ORAL-CONTRACEPTIVES ,Estrogen Replacement Therapy ,WOMEN ,Cell Differentiation ,Middle Aged ,Prognosis ,Menstruation ,Europe ,Female ,HEALTH ,reproductive factors ,Menopause ,EPIC ,Follow-Up Studies - Abstract
Differentiated thyroid carcinoma (TC) is threefold more common in women than in men and, therefore, a role of female hormones in the etiology of differentiated TC has been suggested. We assessed these hypotheses in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Among 345,157 women (mean age 51) followed for an average of 11 years, 508 differentiated TC cases were identified. Hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated using Cox proportional hazards regression models. No significant associations were observed between differentiated TC risk and number of pregnancies, breast feeding, menopausal status, and age at menarche and at menopause. Significant associations were found with history of infertility problems (HR 1.70; 95% CI 1.12-2.60), a recent pregnancy (HR for ≤ 5 vs.5 years before recruitment 3.87; 95% CI 1.43-10.46), menopause type (HR for surgical vs. natural menopause: 2.16; 95% CI 1.41-3.31), oral contraceptive (OC) use at recruitment (HR: 0.48; 95% CI 0.25-0.92) and duration of OC use (HR for ≥ 9 vs. ≤ 1 year: 0.66; 95% CI: 0.50-0.89). An increased risk was also found with hormone replacement therapy use at recruitment (HR = 1.30, 95% CI 1.02-1.67), but this was not significant after adjustment for type of menopause (HR = 1.22, 95% CI 0.95-1.57). Overall, our findings do not support a strong role of reproductive and menstrual factors, and female hormone use in the etiology of differentiated TC. The few observed associations may be real or accounted for by increased surveillance in women who had infertility problems, recent pregnancies or underwent surgical menopause.
- Published
- 2014
136. Nutrient Patterns and Their Food Sources in an International Study Setting: Report from the EPIC Study
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Moskal, Aurelie Pisa, Pedro T. Ferrari, Pietro Byrnes, Graham Freisling, Heinz Boutron-Ruault, Marie-Christine and Cadeau, Claire Nailler, Laura Wendt, Andrea Kuehn, Tilman and Boeing, Heiner Buijsse, Brian Tjonneland, Anne Halkjaer, Jytte Dahm, Christina C. Chiuve, Stephanie E. Quiros, Jose R. Buckland, Genevieve Molina-Montes, Esther Amiano, Pilar and Huerta Castano, Jose M. Barricarte Gurrea, Aurelio Khaw, Kay-Tee Lentjes, Marleen A. Key, Timothy J. Romaguera, Dora and Vergnaud, Anne-Claire Trichopoulou, Antonia Bamia, Christina and Orfanos, Philippos Palli, Domenico Pala, Valeria Tumino, Rosario Sacerdote, Carlotta de Magistris, Maria Santucci and Bueno-de-Mesquita, H. Bas Ocke, Marga C. Beulens, Joline W. J. and Ericson, Ulrika Drake, Isabel Nilsson, Lena M. Winkvist, Anna Weiderpass, Elisabete Hjartaker, Anette Riboli, Elio and Slimani, Nadia
- Abstract
Background: Compared to food patterns, nutrient patterns have been rarely used particularly at international level. We studied, in the context of a multi-center study with heterogeneous data, the methodological challenges regarding pattern analyses. Methodology/Principal Findings: We identified nutrient patterns from food frequency questionnaires (FFQ) in the European Prospective Investigation into Cancer and Nutrition (EPIC) Study and used 24-hour dietary recall (24-HDR) data to validate and describe the nutrient patterns and their related food sources. Associations between lifestyle factors and the nutrient patterns were also examined. Principal component analysis (PCA) was applied on 23 nutrients derived from country-specific FFQ combining data from all EPIC centers (N = 477,312). Harmonized 24-HDRs available for a representative sample of the EPIC populations (N = 34,436) provided accurate mean group estimates of nutrients and foods by quintiles of pattern scores, presented graphically. An overall PCA combining all data captured a good proportion of the variance explained in each EPIC center. Four nutrient patterns were identified explaining 67% of the total variance: Principle component (PC) 1 was characterized by a high contribution of nutrients from plant food sources and a low contribution of nutrients from animal food sources; PC2 by a high contribution of micro-nutrients and proteins; PC3 was characterized by polyunsaturated fatty acids and vitamin D; PC4 was characterized by calcium, proteins, riboflavin, and phosphorus. The nutrients with high loadings on a particular pattern as derived from country-specific FFQ also showed high deviations in their mean EPIC intakes by quintiles of pattern scores when estimated from 24-HDR. Center and energy intake explained most of the variability in pattern scores. Conclusion/Significance: The use of 24-HDR enabled internal validation and facilitated the interpretation of the nutrient patterns derived from FFQs in term of food sources. These outcomes open research opportunities and perspectives of using nutrient patterns in future studies particularly at international level.
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- 2014
137. Thyroid-Stimulating Hormone, Thyroglobulin, and Thyroid Hormones and Risk of Differentiated Thyroid Carcinoma: The EPIC Study
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Rinaldi, Sabina Plummer, Martyn Biessy, Carine Tsilidis, Konstantinos K. Ostergaard, Jane Nautrup Overvad, Kim and Tjonneland, Anne Halkjaer, Jytte Boutron-Ruault, Marie-Christine and Clavel-Chapelon, Francoise Dossus, Laure Kaaks, Rudolf and Lukanova, Annekatrin Boeing, Heiner Trichopoulou, Antonia and Lagiou, Pagona Trichopoulos, Dimitrios Palli, Domenico and Agnoli, Claudia Tumino, Rosario Vineis, Paolo Panico, Salvatore Bueno-de-Mesquita, H. Bas Peeters, Petra H. and Weiderpass, Elisabete Lund, Eiliv Quiros, J. Ramon Agudo, Antonio Molina, Esther Larranaga, Nerea Navarro, Carmen and Ardanaz, Eva Manjer, Jonas Almquist, Martin Sandstrom, Maria and Hennings, Joakim Khaw, Kay-Tee Schmidt, Julie Travis, Ruth C. Byrnes, Graham Scalbert, Augustin Romieu, Isabelle and Gunter, Marc Riboli, Elio Franceschi, Silvia
- Abstract
Background Increased levels of thyroglobulin (Tg) and thyroid-stimulating hormone (TSH) are associated with differentiated thyroid carcinoma (TC) risk, but strong epidemiological evidence is lacking. Methods Three hundred fifty-seven incident TC case patients (n = 300 women and 57 men; mean age at blood collection = 51.5 years) were identified in the EPIC cohort study and matched with 2 (women) or 3 (men) control subjects using incidence density sampling. Matching included study center, sex, age, date, time, and fasting status at blood collection. Levels of total and free (f) thyroxine (T4) and triiodo-thyronine (T3), TSH, Tg, and anti-Tg antibodies (TgAb) were measured by commercially available immunoassays. Odds ratios (ORs) and 95% confidence intervals (CIs) were computed using conditional logistic regression. All statistical tests were two-sided. Results TC risk was positively associated with Tg (OR for the highest vs lowest quartile = 9.15; 95% CI = 5.28 to 15.90; P < .001) and negatively associated with TSH level (OR = 0.56; 95% CI = 0.38 to 0.81; P = .001). Odds ratios were not modified by adjustment for weight and height and were consistent across sexes, age groups, and countries. The association with Tg was stronger in follicular than papillary TC. The odds ratio for TgAb-positivity was 1.50 (95% CI = 1.05 to 2.15; P = .03). Among case patients, TSH level was stable over time, whereas Tg level was higher in proximity to TC diagnosis. Areas under the receiver operating characteristic curve were 57% and 74% for TSH and Tg level, respectively. Conclusions High Tg levels precede by up to 8 years the detection of TC, pointing to a long sojourn time of the disease. Low TSH levels may predispose to TC onset. Neither marker has sufficient accuracy to be a screening test.
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- 2014
138. Main nutrient patterns and colorectal cancer risk in the European Prospective Investigation into Cancer and Nutrition study
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Moskal, Aurélie, primary, Freisling, Heinz, additional, Byrnes, Graham, additional, Assi, Nada, additional, Fahey, Michael T, additional, Jenab, Mazda, additional, Ferrari, Pietro, additional, Tjønneland, Anne, additional, Petersen, Kristina EN, additional, Dahm, Christina C, additional, Hansen, Camilla Plambeck, additional, Affret, Aurélie, additional, Boutron-Ruault, Marie-Christine, additional, Cadeau, Claire, additional, Kühn, Tilman, additional, Katzke, Verena, additional, Iqbal, Khalid, additional, Boeing, Heiner, additional, Trichopoulou, Antonia, additional, Bamia, Christina, additional, Naska, Androniki, additional, Masala, Giovanna, additional, de Magistris, Maria Santucci, additional, Sieri, Sabina, additional, Tumino, Rosario, additional, Sacerdote, Carlotta, additional, Peeters, Petra H, additional, Bueno-de-Mesquita, Bas H, additional, Engeset, Dagrun, additional, Licaj, Idlir, additional, Skeie, Guri, additional, Ardanaz, Eva, additional, Buckland, Genevieve, additional, Castaño, José M Huerta, additional, Quirós, José R, additional, Amiano, Pilar, additional, Molina-Portillo, Elena, additional, Winkvist, Anna, additional, Myte, Robin, additional, Ericson, Ulrika, additional, Sonestedt, Emily, additional, Perez-Cornago, Aurora, additional, Wareham, Nick, additional, Khaw, Kay-Tee, additional, Huybrechts, Inge, additional, Tsilidis, Konstantinos K, additional, Ward, Heather, additional, Gunter, Marc J, additional, and Slimani, Nadia, additional
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- 2016
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139. KRASmutations in blood circulating cell-free DNA: a pancreatic cancer case-control
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Le Calvez-Kelm, Florence, primary, Foll, Matthieu, additional, Wozniak, Magdalena B., additional, Delhomme, Tiffany M., additional, Durand, Geoffroy, additional, Chopard, Priscilia, additional, Pertesi, Maroulio, additional, Fabianova, Eleonora, additional, Adamcakova, Zora, additional, Holcatova, Ivana, additional, Foretova, Lenka, additional, Janout, Vladimir, additional, Vallee, Maxime P., additional, Rinaldi, Sabina, additional, Brennan, Paul, additional, McKay, James D., additional, Byrnes, Graham B., additional, and Scelo, Ghislaine, additional
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- 2016
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140. Elucidating Genomic Characteristics of Lung Cancer Progression from In Situ to Invasive Adenocarcinoma
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Vinayanuwattikun, Chanida, primary, Le Calvez-Kelm, Florence, additional, Abedi-Ardekani, Behnoush, additional, Zaridze, David, additional, Mukeria, Anush, additional, Voegele, Catherine, additional, Vallée, Maxime, additional, Purnomosari, Dewajani, additional, Forey, Nathalie, additional, Durand, Geoffroy, additional, Byrnes, Graham, additional, Mckay, James, additional, Brennan, Paul, additional, and Scelo, Ghislaine, additional
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- 2016
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141. Identification of Circulating Tumor DNA for the Early Detection of Small-cell Lung Cancer
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Fernandez-Cuesta, Lynnette, primary, Perdomo, Sandra, additional, Avogbe, Patrice H., additional, Leblay, Noemie, additional, Delhomme, Tiffany M., additional, Gaborieau, Valerie, additional, Abedi-Ardekani, Behnoush, additional, Chanudet, Estelle, additional, Olivier, Magali, additional, Zaridze, David, additional, Mukeria, Anush, additional, Vilensky, Marta, additional, Holcatova, Ivana, additional, Polesel, Jerry, additional, Simonato, Lorenzo, additional, Canova, Cristina, additional, Lagiou, Pagona, additional, Brambilla, Christian, additional, Brambilla, Elisabeth, additional, Byrnes, Graham, additional, Scelo, Ghislaine, additional, Le Calvez-Kelm, Florence, additional, Foll, Matthieu, additional, McKay, James D., additional, and Brennan, Paul, additional
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- 2016
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142. Abstract 3137: NGS-based detection of KRAS hotspot mutations in plasma cell-free DNA of pancreatic cancer cases
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Le Calvez-Kelm, Florence, primary, Foll, Matthieu, additional, Wozniak, Magdalena B., additional, Durand, Geoffroy, additional, Chopard, Priscilia, additional, Pertesi, Maroulio, additional, Delhomme, Tiffany, additional, Holcatova, Ivana, additional, Foretova, Lenka, additional, Janout, Vladimir, additional, Fabianova, Eleonora, additional, Vallée, Maxime P., additional, Brennan, Paul, additional, McKay, James D., additional, Byrnes, Graham, additional, and Scélo, Ghislaine, additional
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- 2016
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143. Abstract 3156: NGS-based screening for TP53 mutations in circulating cell-free DNA: A first step towards early detection of lung cancers
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Avogbe, Patrice H., primary, Delhomme, Tiffany, additional, Leblay, Noémie, additional, Le Calvez-Kelm, Florence, additional, Chopard, Priscilia, additional, Gaborieau, Valérie, additional, Scelo, Ghislaine, additional, Abedi-Ardekani, Behnoush, additional, Zaridze, David, additional, Mukeria, Anush, additional, Byrnes, Graham, additional, Brennan, Paul, additional, Fernandez-Cuesta, Lynnette, additional, Foll, Matthieu, additional, and McKay, James D., additional
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- 2016
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144. TP53Variations in Human Cancers: New Lessons from the IARC TP53 Database and Genomics Data
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Bouaoun, Liacine, primary, Sonkin, Dmitriy, additional, Ardin, Maude, additional, Hollstein, Monica, additional, Byrnes, Graham, additional, Zavadil, Jiri, additional, and Olivier, Magali, additional
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- 2016
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145. MutSpec: a Galaxy toolbox for streamlined analyses of somatic mutation spectra in human and mouse cancer genomes
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Ardin, Maude, primary, Cahais, Vincent, additional, Castells, Xavier, additional, Bouaoun, Liacine, additional, Byrnes, Graham, additional, Herceg, Zdenko, additional, Zavadil, Jiri, additional, and Olivier, Magali, additional
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- 2016
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146. The 12p13.33/RAD52 locus and genetic susceptibility to squamous cell cancers of upper aerodigestive tract
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Delahaye-Sourdeix, Manon, Oliver, Javier, Timofeeva, Maria N, Gaborieau, Valérie, Johansson, Mattias, Chabrier, Amélie, Wozniak, Magdalena B, Brenner, Darren R, Vallée, Maxime P, Anantharaman, Devasena, Lagiou, Pagona, Holcátová, Ivana, Richiardi, Lorenzo, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V, Barzan, Luigi, Canova, Cristina, Thakker, Nalin S, Conway, David I, Znaor, Ariana, Healy, Claire M, Ahrens, Wolfgang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Fabianova, Eleonora, Mates, Ioan Nicolae, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Curado, Maria Paula, Koifman, Sergio, Menezes, Ana, Wünsch-Filho, Victor, Eluf-Neto, José, Boffetta, Paolo, Garrote, Leticia Fernández, Serraino, Diego, Lener, Marcin, Jaworowska, Ewa, Lubiński, Jan, Boccia, Stefania, Rajkumar, Thangarajan, Samant, Tanuja A, Mahimkar, Manoj B, Matsuo, Keitaro, Franceschi, Silvia, Byrnes, Graham, Brennan, Paul, McKay, James D, Delahaye-Sourdeix, Manon, Oliver, Javier, Timofeeva, Maria N, Gaborieau, Valérie, Johansson, Mattias, Chabrier, Amélie, Wozniak, Magdalena B, Brenner, Darren R, Vallée, Maxime P, Anantharaman, Devasena, Lagiou, Pagona, Holcátová, Ivana, Richiardi, Lorenzo, Kjaerheim, Kristina, Agudo, Antonio, Castellsagué, Xavier, Macfarlane, Tatiana V, Barzan, Luigi, Canova, Cristina, Thakker, Nalin S, Conway, David I, Znaor, Ariana, Healy, Claire M, Ahrens, Wolfgang, Zaridze, David, Szeszenia-Dabrowska, Neonilia, Lissowska, Jolanta, Fabianova, Eleonora, Mates, Ioan Nicolae, Bencko, Vladimir, Foretova, Lenka, Janout, Vladimir, Curado, Maria Paula, Koifman, Sergio, Menezes, Ana, Wünsch-Filho, Victor, Eluf-Neto, José, Boffetta, Paolo, Garrote, Leticia Fernández, Serraino, Diego, Lener, Marcin, Jaworowska, Ewa, Lubiński, Jan, Boccia, Stefania, Rajkumar, Thangarajan, Samant, Tanuja A, Mahimkar, Manoj B, Matsuo, Keitaro, Franceschi, Silvia, Byrnes, Graham, Brennan, Paul, and McKay, James D
- Abstract
Genetic variants located within the 12p13.33/RAD52 locus have been associated with lung squamous cell carcinoma (LUSC). Here, within 5,947 UADT cancers and 7,789 controls from 9 different studies, we found rs10849605, a common intronic variant in RAD52, to be also associated with upper aerodigestive tract (UADT) squamous cell carcinoma cases (OR = 1.09, 95% CI: 1.04-1.15, p = 6x10(-4)). We additionally identified rs10849605 as a RAD52 cis-eQTL inUADT(p = 1x10(-3)) and LUSC (p = 9x10(-4)) tumours, with the UADT/LUSC risk allele correlated with increased RAD52 expression levels. The 12p13.33 locus, encompassing rs10849605/RAD52, was identified as a significant somatic focal copy number amplification in UADT(n = 374, q-value = 0.075) and LUSC (n = 464, q-value = 0.007) tumors and correlated with higher RAD52 tumor expression levels (p = 6x10(-48) and p = 3x10(-29) in UADT and LUSC, respectively). In combination, these results implicate increased RAD52 expression in both genetic susceptibility and tumorigenesis of UADT and LUSC tumors.
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- 2015
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147. Genomic Characterization of Large-Cell Neuroendocrine Lung Tumors
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Fernandez-Cuesta, Lynnette, Peifer, Martin, George, Julie, De Reynies, Aurelien, Sun, Ruping, Altmueller, Janine, Nuernberg, Peter, Olivier, Magali, Ardin, Maude, Blum, Yuna, Laffaire, Julien, Elarouci, Nabila, Petel, Fabien, Mckay, James, Byrnes, Graham, Nagy-Mignotte, Helene, Moro-Sibilot, Denis, Brambilla, Christian, Lantuejoul, Sylvie, Mcleer, Anne, Soltermann, Alex, Brustugun, Odd T., Helland, Aslaug, Solberg, Steinar, Lund-Iversen, Marius, Ansen, Sascha, Wright, Gavin, Russell, Prudence A., Solomon, Benjamin J., Roz, Luca, Pastorino, Ugo, Petersen, Iver, Clement, Joachim H., Saenger, Joerg, Zander, Thomas, Buettner, Reinhard, Haas, Stefan, Brambilla, Elisabeth, Thomas, Roman K., Fernandez-Cuesta, Lynnette, Peifer, Martin, George, Julie, De Reynies, Aurelien, Sun, Ruping, Altmueller, Janine, Nuernberg, Peter, Olivier, Magali, Ardin, Maude, Blum, Yuna, Laffaire, Julien, Elarouci, Nabila, Petel, Fabien, Mckay, James, Byrnes, Graham, Nagy-Mignotte, Helene, Moro-Sibilot, Denis, Brambilla, Christian, Lantuejoul, Sylvie, Mcleer, Anne, Soltermann, Alex, Brustugun, Odd T., Helland, Aslaug, Solberg, Steinar, Lund-Iversen, Marius, Ansen, Sascha, Wright, Gavin, Russell, Prudence A., Solomon, Benjamin J., Roz, Luca, Pastorino, Ugo, Petersen, Iver, Clement, Joachim H., Saenger, Joerg, Zander, Thomas, Buettner, Reinhard, Haas, Stefan, Brambilla, Elisabeth, and Thomas, Roman K.
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- 2015
148. Reproductive and menstrual factors and risk of differentiated thyroid carcinoma: The EPIC study
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Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Zamora-Ros, Raul, Rinaldi, Sabina, Biessy, Carine, Tjonneland, Anne, Halkjaer, Jytte, Fournier, Agnes, Boutron-Ruault, Marie-Christine, Mesrine, Sylvie, Tikk, Kaja, Fortner, Renee T., Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Papatesta, Eleni-Maria, Masala, Giovanna, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Polidoro, Silvia, Peeters, Petra H. M., Bueno-de-Mesquita, H. B(as), Weiderpass, Elisabete, Lund, Eiliv, Argueelles, Marcial, Agudo, Antonio, Molina-Montes, Esther, Navarro, Carmen, Barricarte, Aurelio, Larranaga, Nerea, Manjer, Jonas, Almquist, Martin, Sandstrom, Maria, Hennings, Joakim, Tsilidis, Konstantinos K., Schmidt, Julie A., Khaw, Kay-Thee, Wareham, Nicholas J., Romieu, Isabelle, Byrnes, Graham, Gunter, Marc J., Riboli, Elio, Franceschi, Silvia, Epi Kanker Team 1, JC onderzoeksprogramma Kanker, Cancer, Zamora-Ros, Raul, Rinaldi, Sabina, Biessy, Carine, Tjonneland, Anne, Halkjaer, Jytte, Fournier, Agnes, Boutron-Ruault, Marie-Christine, Mesrine, Sylvie, Tikk, Kaja, Fortner, Renee T., Boeing, Heiner, Foerster, Jana, Trichopoulou, Antonia, Trichopoulos, Dimitrios, Papatesta, Eleni-Maria, Masala, Giovanna, Tagliabue, Giovanna, Panico, Salvatore, Tumino, Rosario, Polidoro, Silvia, Peeters, Petra H. M., Bueno-de-Mesquita, H. B(as), Weiderpass, Elisabete, Lund, Eiliv, Argueelles, Marcial, Agudo, Antonio, Molina-Montes, Esther, Navarro, Carmen, Barricarte, Aurelio, Larranaga, Nerea, Manjer, Jonas, Almquist, Martin, Sandstrom, Maria, Hennings, Joakim, Tsilidis, Konstantinos K., Schmidt, Julie A., Khaw, Kay-Thee, Wareham, Nicholas J., Romieu, Isabelle, Byrnes, Graham, Gunter, Marc J., Riboli, Elio, and Franceschi, Silvia
- Published
- 2015
149. Evaluation of Human Papillomavirus Antibodies and Risk of Subsequent Head and Neck Cancer
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Kreimer, Aimee R. Johansson, Mattias Waterboer, Tim Kaaks, Rudolf Chang-Claude, Jenny Drogen, Dagmar Tjonneland, Anne and Overvad, Kim Ramon Quiros, J. Gonzalez, Carlos A. Jose Sanchez, Maria Larranaga, Nerea Navarro, Carmen Barricarte, Aurelio Travis, Ruth C. Khaw, Kay-Tee Wareham, Nick and Trichopoulou, Antonia Lagiou, Pagona Trichopoulos, Dimitrios and Peeters, Petra H. M. Panico, Salvatore Masala, Giovanna and Grioni, Sara Tumino, Rosario Vineis, Paolo and Bueno-de-Mesquita, H. Bas Laurell, Goran Hallmans, Goran and Manjer, Jonas Ekstrom, Johanna Skeie, Guri Lund, Eiliv and Weiderpass, Elisabete Ferrari, Pietro Byrnes, Graham Romieu, Isabelle Riboli, Elio Hildesheim, Allan Boeing, Heiner and Pawlita, Michael Brennan, Paul
- Abstract
Purpose Human papillomavirus type 16 (HPV16) infection is causing an increasing number of oropharyngeal cancers in the United States and Europe. The aim of our study was to investigate whether HPV antibodies are associated with head and neck cancer risk when measured in prediagnostic sera. Methods We identified 638 participants with incident head and neck cancers (patients; 180 oral cancers, 135 oropharynx cancers, and 247 hypopharynx/larynx cancers) and 300 patients with esophageal cancers as well as 1,599 comparable controls from within the European Prospective Investigation Into Cancer and Nutrition cohort. Prediagnostic plasma samples from patients (collected, on average, 6 years before diagnosis) and control participants were analyzed for antibodies against multiple proteins of HPV16 as well as HPV6, HPV11, HPV18, HPV31, HPV33, HPV45, and HPV52. Odds ratios (ORs) of cancer and 95% CIs were calculated, adjusting for potential confounders. All-cause mortality was evaluated among patients using Cox proportional hazards regression. Results HPV16 E6 seropositivity was present in prediagnostic samples for 34.8% of patients with oropharyngeal cancer and 0.6% of controls (OR, 274; 95% CI, 110 to 681) but was not associated with other cancer sites. The increased risk of oropharyngeal cancer among HPV16 E6 seropositive participants was independent of time between blood collection and diagnosis and was observed more than 10 years before diagnosis. The all-cause mortality ratio among patients with oropharyngeal cancer was 0.30 (95% CI, 0.13 to 0.67), for patients who were HPV16 E6 seropositive compared with seronegative. Conclusion HPV16 E6 seropositivity was present more than 10 years before diagnosis of oropharyngeal cancers. (C) 2013 by American Society of Clinical Oncology
- Published
- 2013
150. Integrative genomic profiling of large-cell neuroendocrine carcinomas reveals distinct subtypes of high-grade neuroendocrine lung tumors.
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George, Julie, Alexandrov, Ludmil B., Seidel, Danila, Leenders, Frauke, Maas, Lukas, Müller, Christian, Dahmen, Ilona, Delhomme, Tiffany M., Ardin, Maude, Leblay, Noemie, Byrnes, Graham, Sun, Ruping, De Reynies, Aurélien, McLeer-Florin, Anne, Bosco, Graziella, Malchers, Florian, Menon, Roopika, Altmüller, Janine, Becker, Christian, and Nürnberg, Peter
- Subjects
LUNG cancer ,NEUROENDOCRINE tumors ,CARCINOMA ,SQUAMOUS cell carcinoma ,RESPIRATORY organs - Abstract
Pulmonary large-cell neuroendocrine carcinomas (LCNECs) have similarities with other lung cancers, but their precise relationship has remained unclear. Here we perform a comprehensive genomic (n = 60) and transcriptomic (n = 69) analysis of 75 LCNECs and identify two molecular subgroups: "type I LCNECs" with bi-allelic TP53 and STK11/KEAP1 alterations (37%), and "type II LCNECs" enriched for bi-allelic inactivation of TP53 and RB1 (42%). Despite sharing genomic alterations with adenocarcinomas and squamous cell carcinomas, no transcriptional relationship was found; instead LCNECs form distinct transcriptional subgroups with closest similarity to SCLC. While type I LCNECs and SCLCs exhibit a neuroendocrine profile with ASCL1
high /DLL3high /NOTCHlow , type II LCNECs bear TP53 and RB1 alterations and differ from most SCLC tumors with reduced neuroendocrine markers, a pattern of ASCL1low /DLL3low /NOTCHhigh , and an upregulation of immune-related pathways. In conclusion, LCNECs comprise two molecularly defined subgroups, and distinguishing them from SCLC may allow stratified targeted treatment ofhigh -grade neuroendocrine lung tumors. [ABSTRACT FROM AUTHOR]- Published
- 2018
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