101. THE CHARACTERISTICS OF Fl AND BACKCROSS HYBRIDS BETWEEN “HIGH LEUKAEMIA” (AKR) AND “AUTOIMMUNE” (NZB) MOUSE STRAINS*
- Author
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Holmes, Margaret C and Burnet, FM
- Abstract
SummaryWhen female NZB mice were crossed with male AKR, the F1 hybrids were more long-lived than either parent.Conversion from negative to positive Coombs test occurred much later than in NZB mice and 3–4 months earlier in F1 females than in males.Kidney lesions were much rarer, but when they occurred they were of the same quality as in NZB mice. The incidence in backcrosses would suggest that a single gene pair is concerned.Thymic lesions in the F1 group showed both the pre-lymphoma nodules of AKR and the germinal centres and other changes characteristic of NZB. Both were much more extensive in female than in male mice.Development of primary thymoma was delayed and many of the “prelymphoma” nodules showed no sign of activity, and would presumably not have initiated a frank lymphoma-leukaemia.Lymphomatous tumours commencing in the thymus or elsewhere had a lower incidence and appeared later in the F1 than in AKR. In the backeross to AKR a considerable number of early thymomas of AKR type were seen.Reticulum cell tumours of the spleen (48), plasmacytomas (16), and lymphoepithelial tumours of the thymus (5) were found amongst 161 neoplastic conditions in the 3 groups.Australian Journal of Experimental Biology and Medical Science (1966) 44, 235–250; doi:10.1038/icb.1966.24
- Published
- 1966
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