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106. Sugar-Sweetened Beverages and Risk of Metabolic Syndrome and Type 2 Diabetes: A meta-analysis

Author

Despres, J.-P., Bray, G. A., Malik, V. S., Willett, W. C., Popkin, B. M., and Hu, F. B.

Abstract

OBJECTIVEConsumption of sugar-sweetened beverages (SSBs), which include soft drinks, fruit drinks, iced tea, and energy and vitamin water drinks has risen across the globe. Regular consumption of SSBs has been associated with weight gain and risk of overweight and obesity, but the role of SSBs in the development of related chronic metabolic diseases, such as metabolic syndrome and type 2 diabetes, has not been quantitatively reviewed.RESEARCH DESIGN AND METHODSWe searched the MEDLINE database up to May 2010 for prospective cohort studies of SSB intake and risk of metabolic syndrome and type 2 diabetes. We identified 11 studies (three for metabolic syndrome and eight for type 2 diabetes) for inclusion in a random-effects meta-analysis comparing SSB intake in the highest to lowest quantiles in relation to risk of metabolic syndrome and type 2 diabetes.RESULTSBased on data from these studies, including 310,819 participants and 15,043 cases of type 2 diabetes, individuals in the highest quantile of SSB intake (most often 1–2 servings/day) had a 26% greater risk of developing type 2 diabetes than those in the lowest quantile (none or

Published
2010
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110. Measurement of active coagulation factors in Autoplex-T with colorimetric active site-specific assay technology

Author

Lundblad Roger L, Edward D. Gomperts, De Vreker R, Kenneth G. Mann, Jenny Rj, Baker D, Hartshorn J, Bergstrom J, Henry S. Kingdon, and Bray G

Subjects
Streptavidin, medicine.medical_treatment, Biotin, Peptide, Factor VIIa, Factor XIa, Factor IXa, Amino Acid Chloromethyl Ketones, Substrate Specificity, chemistry.chemical_compound, medicine, Humans, Biotinylation, Clotting factor, chemistry.chemical_classification, Protease, Chromatography, Binding Sites, medicine.diagnostic_test, Hematology, Blood Coagulation Factors, Coagulation, chemistry, Evaluation Studies as Topic, Immunoassay, Immunology, Factor Xa, Colorimetry, Prothrombin
Abstract

SummaryAutoplex® -T is a partially activated prothrombin complex concentrate used primarily for the treatment of patients expressing factor VIII inhibitors. While Autoplex® -T has a demonstrated record of clinical effectiveness, the procoagulant composition of this material has not been reported. This absence of composition data is a reflection of the lack of techniques appropriate for accurately measuring an individual protease such as factor IXa in complex mixtures of similar proteases. The development of Colorimetric Active Site-Specific ImmunoAssay technology (CASSIA) has permitted the accurate analysis of the coagulant enzymes present in Autoplex® -T. Ten lots of Autoplex® -T were reacted with both biotinylated phenylalanylprolylarginine chloromethylketone and biotinylated glutamylglycylarginine chloromethylketone. Only activated forms of the clotting factors present in Autoplex® -T react with the peptide chloromethylketones and were thus separated from the other proteins present in Autoplex® -T by adsorption onto streptavidin. The individual proteins bound to streptavidin were then detected with specific antibodies. Mean results from the analysis of ten lots of Autoplex® -T (mean values) are as follows: factor XIa, 5.9 nM or 0.8 μg/ml; factor Xa, 46.5 nM or 2.1 μg/ml; factor IXa, 177.8 nM or 11.7 μg/ml; factor VIIa, 68.6 nM or 3.3 μg/ml and factor IIa, 5.3 nM or 0.2 μg/ml. These results are discussed with respect to the mechanism of action of Autoplex® -T in the treatment of factor VIII inhibitor patients.

Published
1998

112. Effect of diet composition on energy expenditure during weight loss: the POUNDS LOST Study

Author

Bray, G A, primary, Smith, S R, additional, DeJonge, L, additional, de Souza, R, additional, Rood, J, additional, Champagne, C M, additional, Laranjo, N, additional, Carey, V, additional, Obarzanek, E, additional, Loria, C M, additional, Anton, S D, additional, Ryan, D H, additional, Greenway, F L, additional, Williamson, D, additional, and Sacks, F M, additional

Published
2011
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126. Obesity:Preventing and managing the global epidemic

Author

Akram, D. S., Astrup, Arne, Atinmo, T., Boissin, J. L., Bray, G. A., Carroll, K. K., Chitson, P., Chunming, C., Dietz, W. H., Hill, J. O., Jéquier, E., Komodiki, C., Matsuzawa, Y., Mollentze, W. F., Moosa, K., Noor, M. I., Reddy, K. S., Seidell, J., Tanphaichitr, V., Uauy, R., Zimmet, P., Akram, D. S., Astrup, Arne, Atinmo, T., Boissin, J. L., Bray, G. A., Carroll, K. K., Chitson, P., Chunming, C., Dietz, W. H., Hill, J. O., Jéquier, E., Komodiki, C., Matsuzawa, Y., Mollentze, W. F., Moosa, K., Noor, M. I., Reddy, K. S., Seidell, J., Tanphaichitr, V., Uauy, R., and Zimmet, P.

Published
2000

132. Sympathoadrenal system and metabolism

Author

Bray, G. A., Bouchard, C., James, W. P. T., Astrup, A., Macdonald, I. A., Bray, G. A., Bouchard, C., James, W. P. T., Astrup, A., and Macdonald, I. A.

Published
1998

135. New end station for the study of gases, liquids, and solid films at the MAX laboratory

Author

Svensson, S, Forsell, JO, Siegbahn, H, Ausmees, A, Bray, G, Sodergren, S, Sundin, S, Osborne, SJ, Aksela, S, Nommiste, E, Jauhiainen, J, Jurvansuu, M, Karvonen, J, Barta, P, Salaneck, WR, Evaldsson, A, Logdlund, M, Fahlman, A, Svensson, S, Forsell, JO, Siegbahn, H, Ausmees, A, Bray, G, Sodergren, S, Sundin, S, Osborne, SJ, Aksela, S, Nommiste, E, Jauhiainen, J, Jurvansuu, M, Karvonen, J, Barta, P, Salaneck, WR, Evaldsson, A, Logdlund, M, and Fahlman, A

Abstract

A new end station equipped with a very high-resolution SES-200 electron energy analyzer has been constructed for the study of gases and soft molecular materials. The analyzer is rotatable around the direction of the photon beam, allowing angular-dependent, Addresses: Svensson S, UNIV UPPSALA, DEPT PHYS, BOX 530, S-75121 UPPSALA, SWEDEN. UNIV OULU, DEPT PHYS SCI, FIN-90570 OULU, FINLAND. LINKOPING UNIV, DEPT PHYS & MEASUREMENT TECHNOL, S-58183 LINKOPING, SWEDEN.

Published
1996

137. FAST DISSOCIATION OF NEUTRAL DOUBLY-EXCITED STATES ABOVE THE S-2P IONIZATION THRESHOLD IN H2S

Author

SVENSSON, S, AKSELA, H, KIVIMAKI, A, SAIRANEN, OP, AUSMEES, A, OSBORNE, SJ, DEBRITO, AN, NOMMISTE, E, BRAY, G, AKSELA, S, SVENSSON, S, AKSELA, H, KIVIMAKI, A, SAIRANEN, OP, AUSMEES, A, OSBORNE, SJ, DEBRITO, AN, NOMMISTE, E, BRAY, G, and AKSELA, S

Abstract

A very rapid dissociation of core doubly excited stares in a molecule has been observed for the first time. The channel is identified in the Anger electron spectra of H2S where the resonating structures, at higher kinetic energy than the normal Auger LVV, Addresses: SVENSSON S, UNIV UPPSALA, DEPT PHYS, BOX 530, S-75121 UPPSALA, SWEDEN. UNIV OULU, DEPT PHYS, SF-90570 OULU, FINLAND. LUND UNIV, MAX LAB, FINNISH SYNCHROTRON RADIAT FACIL, S-22100 LUND, SWEDEN. ESTONIAN ACAD SCI, INST PHYS, 2400 TARTU, ESTONIA.

Published
1995

141. Material control for a reprocessing plant

Author

Rundquist, D., primary, Bray, G., additional, Donelson, S., additional, Glancy, J., additional, Gozani, T., additional, Harris, L., additional, McNamera, R., additional, Pence, D., additional, and Ringham, M., additional

Published
1976
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143. Tunable excitation x-ray-fluorescence spectroscopy in phase-analysis of high-Tc superconductors

Author

Butorin, S.M, Guo, J.H., Wassdahl, N, Bray, G, Glans, Peter, Wiell, T, Duda, L.C., Nordgren, J, Lundström, T, Klauda, M, Markl, J, Fink, C, Saemannischenko, G, Butorin, S.M, Guo, J.H., Wassdahl, N, Bray, G, Glans, Peter, Wiell, T, Duda, L.C., Nordgren, J, Lundström, T, Klauda, M, Markl, J, Fink, C, and Saemannischenko, G

Abstract

O Kalpha x-ray fluorescence of YBa2Cu3O7-delta and Sr0.85Nd0.15CuO2 samples containing CO3(2-) impurities, as well as pure BaCO3, have been studied using tunable monochromatic synchrotron radiation excitation. When the excitation energy is set to the most intense features in the O 1s absorption edge of cuprates and to bound states above this edge the O Kalpha spectra recorded are very similar to those of pure BaCO3 even if the admixture of CO3(2-) is small. The observed changes in the O Kalpha profiles of multi-phase YBa2Cu3O7-delta and Sr0.85Nd0.15CuO2 samples are discussed in terms of different x-ray absorption cross sections for O in the main phase and in the CO3(2-) fraction.

Published
1994

144. Measurement and interpretation of plasma ammonia.

Author

Lee, H. J., Halliday, N., and Bray, G. P.

Abstract

The article discusses the interpretation and measurement of plasma ammonia in patients. Topics covered include the guidance to lessen errors in the measurement of ammonia, information on ammonia metabolism and role of ammonia in liver disease. Also mentioned is the effect of ammonia on hepatic encephalopathy.

Published
2014
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149. Determination of the lifetime width of the argon L1-hole state

Author

Glans, Peter, LaVilla, R.E., Ohno, M, Svensson, S, Bray, G, Wassdahl, N, Nordgren, J, Glans, Peter, LaVilla, R.E., Ohno, M, Svensson, S, Bray, G, Wassdahl, N, and Nordgren, J

Abstract

The width of the argon 2s level was experimentally obtained from x-ray emission-spectroscopy (2.25+/-0.15 eV) and x-ray photoelectron-spectroscopy (XPS) (2.25+/-0.05 eV) measurements. A theoretical value of 1.85 eV was obtained by a Green's-function calculation. A high-energy satellite located 2.7+/-0.2 eV above the L1-M2,3 x-ray emission transition was confirmed and identified as the 2s(-1)3p-1-->3p-2 double-hole transition. The XPS measurement of the argon 2s ionization energy gave a value of 326.25(5) eV.

Published
1993

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