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101. Allgemeinärzte und andere 'kreative Köpfe'. Entwicklung einer Öffentlichkeitskampagne zum Thema Antibiotikaverordnungen in Zusammenarbeit mit Studierenden des Fachs Kommunikationsdesign

Author

Altiner, A, Brand, T, Garbe, K, Leyh, M, Kamradt, M, Kaufmann-Kolle, P, Uhlmann, L, Voss, A, Wensing, M, Weber, D, and Wollny, A

Subjects
Antibiotikaverordnungen bei akuten Atemwegsinfekten, Interventionsentwicklung, ddc: 610, Verzahnung von Allgemeinmedizin und Kommunikationsdesign, 610 Medical sciences, Medicine
Abstract

Hintergrund: In der BMG geförderten Studie „Verbesserung des Umgangs mit Antibiotika bei akuten Atemwegsinfekten in der deutschen Primärversorgung (Change-3)“ arbeiten Wissenschaftler des allgemeinmedizinischen Instituts der Universitätsmedizin Rostock mit Hochschullehrern[zum vollständigen Text gelangen Sie über die oben angegebene URL], 52. Kongress für Allgemeinmedizin und Familienmedizin

Published
2018
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102. Synthetic simulations of the extragalactic sky seen by eROSITA

Author

Clerc, N., Ramos-Ceja, M., Ridl, J., Lamer, G., Brunner, H., Hofmann, F., Comparat, J., Pacaud, F., Käfer, F., Reiprich, T., Merloni, A., Schmid, C., Brand, T., Wilms, J., Friedrich, P., Finoguenov, A., Dauser, T., Kreykenbohm, I., Institut de recherche en astrophysique et planétologie (IRAP), Université Toulouse III - Paul Sabatier (UT3), Université Fédérale Toulouse Midi-Pyrénées-Université Fédérale Toulouse Midi-Pyrénées-Observatoire Midi-Pyrénées (OMP), Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS), Max Planck Institute for Extraterrestrial Physics (MPE), Max-Planck-Gesellschaft, Argelander Institute for Astronomy (AlfA), Rheinische Friedrich-Wilhelms-Universität Bonn, Leibniz-Institut für Astrophysik Potsdam (AIP), Argelander-Institut für Astronomie (AlfA), Dr. Karl-Remeis-Sternwarte, Erlangen Centre for Astroparticle Physics (ECAP), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU)-Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Friedrich-Alexander Universität Erlangen-Nürnberg (FAU), Department of Physics [Helsinki], Falculty of Science [Helsinki], University of Helsinki-University of Helsinki, Institut national des sciences de l'Univers (INSU - CNRS)-Université Toulouse III - Paul Sabatier (UT3), and Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Université Fédérale Toulouse Midi-Pyrénées-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Météo France-Centre National d'Études Spatiales [Toulouse] (CNES)-Centre National de la Recherche Scientifique (CNRS)-Institut de Recherche pour le Développement (IRD)-Centre National de la Recherche Scientifique (CNRS)

Subjects
[SDU.ASTR.CO]Sciences of the Universe [physics]/Astrophysics [astro-ph]/Cosmology and Extra-Galactic Astrophysics [astro-ph.CO], ComputingMilieux_MISCELLANEOUS
Abstract

International audience

Published
2018
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107. Superdiversity, population health and health care : opportunities and challenges in a changing world

Author

Phillimore, J. A., Bradby, Hannah, Brand, T., Phillimore, J. A., Bradby, Hannah, and Brand, T.

Abstract

Objectives: Ethno-national approaches to research public health and migrant outcomes have dominated for decades but lack efficacy in a globalised world and in view of the intractable nature of health outcome inequalities for migrant and minority groups. This article highlights some of the challenges and opportunities associated with a superdiversity perspective in public health research. Superdiversity and ethno-national approaches: Migration patterns have changed with more people arriving from more places and the diversification of diversity meaning that the ethno-national categories utilised in public health research have reduced explanatory potential. The example of maternal and perinatal mortality in the United Kingdom: Adjusting UK perinatal mortality rates by five ethnic groups based on assumptions of relationships between high levels of risk and ethnic groups masks the scale of inequality faced by groups wherein mortality rates are increasing and highlights some of the difficulties associated with using ethno-national classifications. A superdiversity perspective: A superdiversity approach moves beyond ethno-nationalism to socially locate groups focussing on commonalities and differences across spaces and characteristics and employing intracategorical or anticategorical approaches. Conclusions: Superdiversity brings new levels of demographic complexity and fluidity. Greater reflexivity is needed in diversity research with justification of classifications used for analysis necessary when research questions are developed.

Published
2019
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108. Gut Microbial Associations to Plasma Metabolites Linked to Cardiovascular Phenotypes and Risk

Author

Kurilshikov, A., Munckhof, I.C.L. van den, Chen, L, Bonder, M.J., Schraa, K., Rutten, J.H.W., Riksen, N.P., Graaf, J. de, Oosting, M., Sanna, S., Joosten, L.A.B., Graaf, M. van der, Brand, T, Koonen, D.P., van Faassen, M., Slagboom, P.Eline, Xavier, R.J., Kuipers, F., Hofker, M.H., Wijmenga, C., Netea, M.G., Zhernakova, A., Fu, J., Kurilshikov, A., Munckhof, I.C.L. van den, Chen, L, Bonder, M.J., Schraa, K., Rutten, J.H.W., Riksen, N.P., Graaf, J. de, Oosting, M., Sanna, S., Joosten, L.A.B., Graaf, M. van der, Brand, T, Koonen, D.P., van Faassen, M., Slagboom, P.Eline, Xavier, R.J., Kuipers, F., Hofker, M.H., Wijmenga, C., Netea, M.G., Zhernakova, A., and Fu, J.

Abstract

Contains fulltext : 204147.pdf (publisher's version ) (Closed access), RATIONALE: Altered gut microbial composition has been linked to cardiovascular diseases (CVDs), but its functional links to host metabolism and immunity in relation to CVD development remain unclear. OBJECTIVES: To systematically assess functional links between the microbiome and the plasma metabolome, cardiometabolic phenotypes, and CVD risk and to identify diet-microbe-metabolism-immune interactions in well-documented cohorts. METHODS AND RESULTS: We assessed metagenomics-based microbial associations between 231 plasma metabolites and microbial species and pathways in the population-based LLD (Lifelines DEEP) cohort (n=978) and a clinical obesity cohort (n=297). After correcting for age, sex, and body mass index, the gut microbiome could explain

Published
2019

110. Converting habits of antibiotic use for respiratory tract infections in German primary care - study protocol of the cluster-randomized controlled CHANGE-3 trial

Author

Wollny, A., Altiner, A., Brand, T. van den, Garbe, K., Kamradt, M., Kaufmann-Kolle, P., Leyh, M., Poss-Doering, R., Szecsenyi, J., Uhlmann, L., Voss, Arwed, Weber, D., Wensing, M., Loffler, C., Wollny, A., Altiner, A., Brand, T. van den, Garbe, K., Kamradt, M., Kaufmann-Kolle, P., Leyh, M., Poss-Doering, R., Szecsenyi, J., Uhlmann, L., Voss, Arwed, Weber, D., Wensing, M., and Loffler, C.

Abstract

Contains fulltext : 202225.pdf (publisher's version ) (Open Access), BACKGROUND: The overuse of antibiotics is a major cause for the worldwide rise of antibiotic resistance. Although it is well known that acute respiratory tract infections (ARTI) are mainly caused by viruses and are often self limiting, antibiotics are too frequently prescribed in primary care. CHANGE-3 examines whether a complex intervention focusing on improving communication and provision of prescribing feedback reduces antibiotic use in patients suffering from ARTI. METHODS/DESIGN: The CHANGE-3 trial is a cluster-randomized controlled trial nested within a web-based public campaign conducted in two regions in Germany. A total of 114 medical practices will be included. Practices randomized to the intervention will receive a practice-specific antibiotic-prescription feedback and an educational outreach visit. During the visit the whole practice team will receive an introduction to e-learning modules addressing patient-centered communication on antibiotics. Furthermore, the practices will receive tablet PCs with information on antibiotics and the treatment of ARTI to be presented to patients. Practices randomized to the control will provide care as usual. The primary outcome measure is the antibiotic prescribing rate for patients with a history of ARTI. Data collected before the intervention, during the intervention and after the intervention will be compared. The use of narrow- vs. broad-spectrum antibiotics will be analyzed as a secondary outcome. A process evaluation is also part of the trial. DISCUSSION: This study should contribute to the growing body of research on reducing antibiotic prescription. TRIAL REGISTRATION: ISRCTN, ISRCTN15061174 . Registered retrospectively on 13 July 2018.

Published
2019

111. Large expert-curated database for benchmarking document similarity detection in biomedical literature search

Author

Brown, P., Zhou, Y., Tan, A. -C., El-Esawi, M. A., Liehr, T., Blanck, O., Gladue, D. P., Almeida, G. M. F., Cernava, T., Sorzano, C. O., Yeung, A. W. K., Engel, M. S., Chandrasekaran, A. R., Muth, T., Staege, M. S., Daulatabad, S. V., Widera, D., Zhang, J., Meule, A., Honjo, K., Pourret, O., Yin, C. -C., Zhang, Z., Cascella, M., Flegel, W. A., Goodyear, C. S., van Raaij, M. J., Bukowy-Bieryllo, Z., Campana, L. G., Kurniawan, N. A., Lalaouna, D., Huttner, F. J., Ammerman, B. A., Ehret, F., Cobine, P. A., Tan, E. -C., Han, H., Xia, W., Mccrum, C., Dings, R. P. M., Marinello, F., Nilsson, H., Nixon, B., Voskarides, K., Yang, L., Costa, V. D., Bengtsson-Palme, J., Bradshaw, W., Grimm, D. G., Kumar, N., Martis, E., Prieto, D., Sabnis, S. C., Amer, S. E. D. R., Liew, A. W. C., Perco, P., Rahimi, F., Riva, G., Zhang, C., Devkota, H. P., Ogami, K., Basharat, Z., Fierz, W., Siebers, R., Tan, K. H., Boehme, K. A., Brenneisen, P., Brown, J. A. L., Dalrymple, B. P., Harvey, D. J., Ng, G., Werten, S., Bleackley, M., Dai, Z., Dhariwal, R., Gelfer, Y., Hartmann, M. D., Miotla, P., Tamaian, R., Govender, P., Gurney-Champion, O. J., Kauppila, J. H., Zhang, X., Echeverria, N., Subhash, S., Sallmon, H., Tofani, M., Bae, T., Bosch, O., Cuiv, P. O., Danchin, A., Diouf, B., Eerola, T., Evangelou, E., Filipp, F., Klump, H., Kurgan, L., Smith, S. S., Terrier, O., Tuttle, N., Ascher, D. B., Janga, S. C., Schulte, L. N., Becker, D., Browngardt, C., Bush, S. J., Gaullier, G., Ide, K., Meseko, C., Werner, G. D. A., Zaucha, J., Al-Farha, A. A., Greenwald, N. F., Popoola, S. I., Rahman, S., Xu, J., Yang, S. Y., Hiroi, N., Alper, O. M., Baker, C. I., Bitzer, M., Chacko, G., Debrabant, B., Dixon, R., Forano, E., Gilliham, M., Kelly, S., Klempnauer, K. -H., Lidbury, B. A., Lin, M. Z., Lynch, I., Ma, W., Maibach, E. W., Mather, D. E., Nandakumar, K. S., Ohgami, R. S., Parchi, P., Tressoldi, P., Xue, Y., Armitage, C., Barraud, P., Chatzitheochari, S., Coelho, L. P., Diao, J., Doxey, A. C., Gobet, A., Hu, P., Kaiser, S., Mitchell, K. M., Salama, M. F., Shabalin, I. G., Song, H., Stevanovic, D., Yadollahpour, A., Zeng, E., Zinke, K., Alimba, C. G., Beyene, T. J., Cao, Z., Chan, S. S., Gatchell, M., Kleppe, A., Piotrowski, M., Torga, G., Woldesemayat, A. A., Cosacak, M. I., Haston, S., Ross, S. A., Williams, R., Wong, A., Abramowitz, M. K., Effiong, A., Lee, S., Abid, M. B., Agarabi, C., Alaux, C., Albrecht, D. R., Atkins, G. J., Beck, C. R., Bonvin, A. M. J. J., Bourke, E., Brand, T., Braun, R. J., Bull, J. A., Cardoso, P., Carter, D., Delahay, R. M., Ducommun, B., Duijf, P. H. G., Epp, T., Eskelinen, E. -L., Fallah, M., Farber, D. B., Fernandez-Triana, J., Feyerabend, F., Florio, T., Friebe, M., Furuta, S., Gabrielsen, M., Gruber, J., Grybos, M., Han, Q., Heinrich, M., Helantera, H., Huber, M., Jeltsch, A., Jiang, F., Josse, C., Jurman, G., Kamiya, H., de Keersmaecker, K., Kristiansson, E., de Leeuw, F. -E., Li, J., Liang, S., Lopez-Escamez, J. A., Lopez-Ruiz, F. J., Marchbank, K. J., Marschalek, R., Martin, C. S., Miele, A. E., Montagutelli, X., Morcillo, E., Nicoletti, R., Niehof, M., O'Toole, R., Ohtomo, T., Oster, H., Palma, J. -A., Paterson, R., Peifer, M., Portilla, M., Portillo, M. C., Pritchard, A. L., Pusch, S., Raghava, G. P. S., Roberts, N. J., Ross, K., Schuele, B., Sergeant, K., Shen, J., Stella, A., Sukocheva, O., Uversky, V. N., Vanneste, S., Villet, M. H., Viveiros, M., Vorholt, J. A., Weinstock, C., Yamato, M., Zabetakis, I., Zhao, X., Ziegler, A., Aizat, W. M., Atlas, L., Bridges, K. M., Chakraborty, S., Deschodt, M., Domingues, H. S., Esfahlani, S. S., Falk, S., Guisado, J. L., Kane, N. C., Kueberuwa, G., Lau, C. L., Liang, D., Liu, E., Luu, A. M., Ma, C., Ma, L., Moyer, R., Norris, A. D., Panthee, S., Parsons, J. R., Peng, Y., Pinto, I. M., Reschke, C. R., Sillanpaa, E., Stewart, C. J., Uhle, F., Yang, H., Zhou, K., Zhu, S., Ashry, M., Bergsland, N., Berthold, M., Chen, C. -E., Colella, V., Cuypers, M., Eskew, E. A., Fan, X., Gajda, M., Gonzalezlez-Prendes, R., Goodin, A., Graham, E. B., Groen, E. J. N., Gutierrez-Sacristan, A., Habes, M., Heffler, E., Higginbottom, D. B., Janzen, T., Jayaraman, J., Jibb, L. A., Jongen, S., Kinyanjui, T., Koleva-Kolarova, R. G., Li, Z., Liu, Y. -P., Lund, B. A., Lussier, A. A., Mier, P., Moore, M. D., Nagler, K., Orme, M. W., Pearson, J. A., Prajapati, A. S., Saito, Y., Troder, S. E., Uchendu, F., Verloh, N., Voutchkova, D. D., Abu-Zaid, A., Bakkach, J., Baumert, P., Dono, M., Hanson, J., Herbelet, S., Hobbs, E., Kulkarni, A., Liu, S., Loft, N. D., Reddan, T., Senghore, T., Vindin, H., Xu, H., Bannon, R., Chen, B., Cheung, J. T. K., Cooper, J., Esnakula, A. K., Feghali, K. A., Ghelardi, E., Gnasso, A., Horbar, J., Lai, H. M., Ma, R., Pan, Z., Peres, M. A., Pranata, R., Seow, E., Sydes, M., Testoni, I., Westermair, A. L., Yang, Y., Afnan, M., Albiol, J., Albuquerque, L. G., Amir, S., Amiya, E., Amorim, R. M., An, Q., Andersen, S. U., Aplin, J. D., Argyropoulos, C., Asmann, Y. W., Assaeed, A. M., Atanasov, A. G., Atchison, D. A., Avery, S. V., Avillach, P., Baade, P. D., Backman, L., Badie, C., Baldi, A., Ball, E., Bardot, O., Barnett, A. G., Basner, M., Batra, J., Bazanova, O. M., Beale, A., Beddoe, T., Bell, M. L., Berezikov, E., Berners-Price, S., Bernhardt, P., Berry, E., Bessa, T. B., Billington, C., Birch, J., Blakely, R. D., Blaskovich, M. A. T., Blum, R., Boelaert, M., Bogdanos, D., Bosch, C., Bourgoin, T., Bouvard, D., Boykin, L. M., Bradley, G., Braun, D., Brownlie, J., Bruhl, A., Burt, A., Butler, L. M., Byrareddy, S. N., Byrne, H. J., Cabantous, S., Calatayud, S., Candal, E., Carlson, K., Casillas, S., Castelvetro, V., Caswell, P. T., Cavalli, G., Cerovsky, V., Chagoyen, M., Chen, C. -S., Chen, D. F., Chen, H., Chen, J. -T., Chen, Y., Cheng, C., Cheng, J., Chinapaw, M., Chinopoulos, C., Cho, W. C. S., Chong, L., Chowdhury, D., Chwalibog, A., Ciresi, A., Cockcroft, S., Conesa, A., Cook, P. A., Cooper, D. N., Coqueret, O., Corea, E. M., Costa, A., Costa, E., Coupland, C., Crawford, S. Y., Cruz, A. D., Cui, H., Cui, Q., Culver, D. C., D'Angiulli, A., Dahms, T. E. S., Daigle, F., Dalgleish, R., Danielsen, H. E., Darras, S., Davidson, S. M., Day, D. A., Degirmenci, V., Demaison, L., Devriendt, K., Ding, J., Dogan, Y., Dong, X. C., Donner, C. F., Dressick, W., Drevon, C. A., Duan, H., Ducho, C., Dumaz, N., Dwarakanath, B. S., Ebell, M. H., Eisenhardt, S., Elkum, N., Engel, N., Erickson, T. B., Fairhead, M., Faville, M. J., Fejzo, M. S., Festa, F., Feteira, A., Flood-Page, P., Forsayeth, J., Fox, S. A., Franks, S. J., Frentiu, F. D., Frilander, M. J., Fu, X., Fujita, S., Galea, I., Galluzzi, L., Gani, F., Ganpule, A. P., Garcia-Alix, A., Gedye, K., Giordano, M., Giunta, C., Gleeson, P. A., Goarant, C., Gong, H., Gora, D., Gough, M. J., Goyal, R., Graham, K. E., Grande-Perez, A., Graves, P. M., Greidanus, H., Grice, D., Grunau, C., Gumulya, Y., Guo, Y., Gurevich, V. V., Gusev, O., Hacker, E., Hage, S. R., Hagen, G., Hahn, S., Haller, D. M., Hammerschmidt, S., Han, J., Han, R., Handfield, M., Hapuarachchi, H. C., Harder, T., Hardingham, J. E., Heck, M., Heers, M., Hew, K. F., Higuchi, Y., Hilaire, C. St., Hilton, R., Hodzic, E., Hone, A., Hongoh, Y., Hu, G., Huber, H. P., Hueso, L. E., Huirne, J., Hurt, L., Idborg, H., Ikeo, K., Ingley, E., Jakeman, P. M., Jensen, A., Jia, H., Jia, S., Jiang, J., Jiang, X., Jin, Y., Jo, D., Johnson, A. M., Johnston, M., Jonscher, K. R., Jorens, P. G., Jorgensen, J. O. L., Joubert, J. W., Jung, S. -H., Junior, A. M., Kahan, T., Kamboj, S. K., Kang, Y. -K., Karamanos, Y., Karp, N. A., Kelly, R., Kenna, R., Kennedy, J., Kersten, B., Khalaf, R. A., Khalid, J. M., Khatlani, T., Khider, T., Kijanka, G. S., King, S. R. B., Kluz, T., Knox, P., Kobayashi, T., Koch, K. -W., Kohonen-Corish, M. R. J., Kong, X., Konkle-Parker, D., Korpela, K. M., Kostrikis, L. G., Kraiczy, P., Kratz, H., Krause, G., Krebsbach, P. H., Kristensen, S. R., Kumari, P., Kunimatsu, A., Kurdak, H., Kwon, Y. D., Lachat, C., Lagisz, M., Laky, B., Lammerding, J., Lange, M., Larrosa, M., Laslett, A. L., Laverman, G. D., Leclair, E. E., Lee, K. -W., Lee, M. -Y., Lee, M. -S., Li, G., Lieb, K., Lim, Y. Y., Lindsey, M. L., Line, P. -D., Liu, D., Liu, F., Liu, H., Lloyd, V. K., Lo, T. -W., Locci, E., Loidl, J., Lorenzen, J., Lorkowski, S., Lovell, N. H., Lu, H., Lu, W., Lu, Z., Luengo, G. S., Lundh, L. -G., Lysy, P. A., Mabb, A., Mack, H. G., Mackey, D. A., Mahdavi, S. R., Maher, P., Maher, T., Maity, S. N., Malgrange, B., Mamoulakis, C., Mangoni, A. A., Manke, T., Manstead, A. S. R., Mantalaris, A., Marsal, J., Marschall, H. -U., Martin, F. L., Martinez-Raga, J., Martinez-Salas, E., Mathieu, D., Matsui, Y., Maza, E., Mccutcheon, J. E., Mckay, G. J., Mcmillan, B., Mcmillan, N., Meads, C., Medina, L., Merrick, B. A., Metzger, D. W., Meunier, F. A., Michaelis, M., Micheau, O., Mihara, H., Mintz, E. M., Mizukami, T., Moalic, Y., Mohapatra, D. P., Monteiro, A., Montes, M., Moran, J. V., Morozov, S. Y., Mort, M., Murai, N., Murphy, D. J., Murphy, S. K., Murray, S. A., Naganawa, S., Nammi, S., Nasios, G., Natoli, R. M., Nguyen, F., Nicol, C., van Nieuwerburgh, F., Nilsen, E. B., Nobile, C. J., O'Mahony, M., Ohlsson, S., Olatunbosun, O., Olofsson, P., Ortiz, A., Ostrikov, K., Otto, S., Outeiro, T. F., Ouyang, S., Paganoni, S., Page, A., Palm, C., Paradies, Y., Parsons, M. H., Parsons, N., Pascal, P., Paul, E., Peckham, M., Pedemonte, N., Pellizzon, M. A., Petrelli, M., Pichugin, A., Pinto, C. J. C., Plevris, J. N., Pollesello, P., Polz, M., Ponti, G., Porcelli, P., Prince, M., Quinn, G. P., Quinn, T. J., Ramula, S., Rappsilber, J., Rehfeldt, F., Reiling, J. H., Remacle, C., Rezaei, M., Riddick, E. W., Ritter, U., Roach, N. W., Roberts, D. D., Robles, G., Rodrigues, T., Rodriguez, C., Roislien, J., Roobol, M. J., Rowe, A., Ruepp, A., van Ruitenbeek, J., Rust, P., Saad, S., Sack, G. H., Santos, M., Saudemont, A., Sava, G., Schrading, S., Schramm, A., Schreiber, M., Schuler, S., Schymkowitz, J., Sczyrba, A., Seib, K. L., Shi, H. -P., Shimada, T., Shin, J. -S., Shortt, C., Silveyra, P., Skinner, D., Small, I., Smeets, P. A. M., So, P. -W., Solano, F., Sonenshine, D. E., Song, J., Southall, T., Speakman, J. R., Srinivasan, M. V., Stabile, L. P., Stasiak, A., Steadman, K. J., Stein, N., Stephens, A. W., Stewart, D. I., Stine, K., Storlazzi, C., Stoynova, N. V., Strzalka, W., Suarez, O. M., Sultana, T., Sumant, A. V., Summers, M. J., Sun, G., Tacon, P., Tanaka, K., Tang, H., Tanino, Y., Targett-Adams, P., Tayebi, M., Tayyem, R., Tebbe, C. C., Telfer, E. E., Tempel, W., Teodorczyk-Injeyan, J. A., Thijs, G., Thorne, S., Thrift, A. G., Tiffon, C., Tinnefeld, P., Tjahjono, D. H., Tolle, F., Toth, E., Del Tredici, A. L., Tsapas, A., Tsirigotis, K., Turak, A., Tzotzos, G., Udo, E. E., Utsumi, T., Vaidyanathan, S., Vaillant, M., Valsesia, A., Vandenbroucke, R. E., Veiga, F. H., Vendrell, M., Vesk, P. A., Vickers, P., Victor, V. M., Villemur, R., Vohl, M. -C., Voolstra, C. R., Vuillemin, A., Wakelin, S., Waldron, L., Walsh, L. J., Wang, A. Y., Wang, F., Wang, Y., Watanabe, Y., Weigert, A., Wen, J. -C., Wham, C., White, E. P., Wiener, J., Wilharm, G., Wilkinson, S., Willmann, R., Wilson, C., Wirth, B., Wojan, T. R., Wolff, M., Wong, B. M., Wu, T. -W., Wuerbel, H., Xiao, X., Xu, D., Xu, J. W., Xue, B., Yalcin, S., Yan, H., Yang, E. -C., Yang, S., Yang, W., Ye, Y., Ye, Z. -Q., Yli-Kauhaluoma, J., Yoneyama, H., Yu, Y., Yuan, G. -C., Yuh, C. -H., Zaccolo, M., Zeng, C., Zevnik, B., Zhang, L., Zhang, Y., Zhang, Z. -Y., Zhao, Y., Zhou, M., Zuberbier, T., Aanei, C. M., Ahmad, R., Al-Lawama, M., Alanio, A., Allardyce, J., Alonso-Caneiro, D., Atack, J. M., Baier, D., Bansal, A., Benezeth, Y., Berbesque, C., Berrevoet, F., Biedermann, P. H. W., Bijleveld, E., Bittner, F., Blombach, F., van den Bos, W., Boudreau, S. A., Bramoweth, A. D., Braubach, O., Cai, Y., Campbell, M., Catry, T., Chen, X., Cheng, S., Chung, H. -J., Chavez-Fumagalli, M. A., Conway, A., Costa, B. M., Cyr, N., Dean, L. T., Denzel, M. S., Dlamini, S. V., Dudley, K. J., Dufies, M., Ecke, T., Eckweiler, D., Eixarch, E., El-Adawy, H., Emmrich, J. V., Eustace, A. J., Falter-Wagner, C. M., Farhoudi, R., Fuss, J., Gao, J., Gill, M. R., Gloyn, L., Goggs, R., Govinden, U., Greene, G., Greiff, V., Grundle, D. 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Abstract

Document recommendation systems for locating relevant literature have mostly relied on methods developed a decade ago. This is largely due to the lack of a large offline gold-standard benchmark of relevant documents that cover a variety of research fields such that newly developed literature search techniques can be compared, improved and translated into practice. To overcome this bottleneck, we have established the RElevant LIterature SearcH consortium consisting of more than 1500 scientists from 84 countries, who have collectively annotated the relevance of over 180 000 PubMed-listed articles with regard to their respective seed (input) article/s. The majority of annotations were contributed by highly experienced, original authors of the seed articles. The collected data cover 76% of all unique PubMed Medical Subject Headings descriptors. No systematic biases were observed across different experience levels, research fields or time spent on annotations. More importantly, annotations of the same document pairs contributed by different scientists were highly concordant. We further show that the three representative baseline methods used to generate recommended articles for evaluation (Okapi Best Matching 25, Term Frequency-Inverse Document Frequency and PubMed Related Articles) had similar overall performances. Additionally, we found that these methods each tend to produce distinct collections of recommended articles, suggesting that a hybrid method may be required to completely capture all relevant articles. The established database server located at https://relishdb.ict.griffith.edu.au is freely available for the downloading of annotation data and the blind testing of new methods. We expect that this benchmark will be useful for stimulating the development of new powerful techniques for title and title/abstract-based search engines for relevant articles in biomedical science.

Published
2019

112. SIRENA: Software for Athena X-IFU event reconstruction

Author

Ministerio de Economía y Competitividad (España), European Commission, Ceballos, María Teresa, Cobo, Beatriz, Peille, Philippe, Wilms, Jörn, Brand, T., Dauser, T., Bandler, S., Smith, S., Ministerio de Economía y Competitividad (España), European Commission, Ceballos, María Teresa, Cobo, Beatriz, Peille, Philippe, Wilms, Jörn, Brand, T., Dauser, T., Bandler, S., and Smith, S.

Abstract

SIRENA is a software prolotype package currently in development for the reconstruction of the energy of the X-ray events detected by the X-IFU instrument of the Athena observatory. During this development phase it is integrated in a larger project for Athena end-t<>-end simolations (SIXTE), where X-IFU data can be simulated, initially triggered and finally, energy reconstructed, thus helping in the assessment of different instrument configurations. SIRENA implements different analysis and triggering algorithms with the aim of testing their performance in terms of energy resolution and computing resources. The best performance algorithms, optimized for in-flight use, will be finally implernented on board in the X-IFU Digital Readout Electronics (ORE) unit.

Published
2019

113. 'Kinderen helpen ons om anders te kijken' : Missing Chapter Foundation werkt samen met Waterschap Vallei en Veluwe : case study

Author

Brand, T. and Brand, T.

Abstract

Overheden lopen het risico op een tunnelvisie waardoor ze de aansluiting met de maatschappij verliezen. ‘Van buiten naar binnen denken’ is het devies. Juist waterschappen staan vanwege de klimaatverandering voor grote opgaven. Terwijl tienduizenden scholieren de straat op gaan voor een beter klimaatbeleid, werken waterschappen al geruime tijd aan het aanpassen van de leefomgeving en het beperken van de CO2-uitstoot. “Maar daar kan nog wel een tandje bij. Klimaat gaat over de nabije en verre toekomst en kinderen zijn daarbij heel belangrijke adviseurs voor ons,” zegt dijkgraaf Tanja Klip-Martin over het inschakelen van een Raad van Kinderen.

Published
2019

114. A Micromechanical INS/GPS System for Small Satellites

Author

Barbour, N, Brand, T, Haley, R, Socha, M, Stoll, J, Ward, P, and Weinberg, M

Subjects
Space Communications, Spacecraft Communications, Command And Tracking
Abstract

The cost and complexity of large satellite space missions continue to escalate. To reduce costs, more attention is being directed toward small lightweight satellites where future demand is expected to grow dramatically. Specifically, micromechanical inertial systems and microstrip global positioning system (GPS) antennas incorporating flip-chip bonding, application specific integrated circuits (ASIC) and MCM technologies will be required. Traditional microsatellite pointing systems do not employ active control. Many systems allow the satellite to point coarsely using gravity gradient, then attempt to maintain the image on the focal plane with fast-steering mirrors. Draper's approach is to actively control the line of sight pointing by utilizing on-board attitude determination with micromechanical inertial sensors and reaction wheel control actuators. Draper has developed commercial and tactical-grade micromechanical inertial sensors, The small size, low weight, and low cost of these gyroscopes and accelerometers enable systems previously impractical because of size and cost. Evolving micromechanical inertial sensors can be applied to closed-loop, active control of small satellites for micro-radian precision-pointing missions. An inertial reference feedback control loop can be used to determine attitude and line of sight jitter to provide error information to the controller for correction. At low frequencies, the error signal is provided by GPS. At higher frequencies, feedback is provided by the micromechanical gyros. This blending of sensors provides wide-band sensing from dc to operational frequencies. First order simulation has shown that the performance of existing micromechanical gyros, with integrated GPS, is feasible for a pointing mission of 10 micro-radians of jitter stability and approximately 1 milli-radian absolute error, for a satellite with 1 meter antenna separation. Improved performance micromechanical sensors currently under development will be suitable for a range of micro-nano-satellite applications.

Published
1995

115. New kids on the block: The Popeye domain containing (POPDC) protein family acting as a novel class of cAMP effector proteins in striated muscle

Author

Brand, T, Schindler, Medical Research Council (MRC), British Heart Foundation, The Magdi Yacoub Institute, and Association Francaise Contre les Myopathies

Subjects
Biochemistry & Molecular Biology, Popeye domain containing, Protein interaction, 0601 Biochemistry And Cell Biology, Limb-girdle muscular dystrophy, cAMP signalling, Heart disease, Stress-induced bradycardia, Atrioventricular block
Abstract

The cyclic 3’,5’-adenosine monophosphate (cAMP) signalling pathway constitutes an ancient signal transduction pathway present in prokaryotes and eukaryotes. Previously, it was thought that in eukaryotes three effector proteins mediate cAMP signalling, namely protein kinase A (PKA), exchange factor directly activated by cAMP (EPAC) and the cyclic-nucleotide gated channels. However, recently a novel family of cAMP effector proteins emerged and was termed the Popeye domain containing (POPDC) family, which consists of three members POPDC1, POPDC2 and POPDC3. POPDC proteins are transmembrane proteins, which are abundantly present in striated and smooth muscle cells. POPDC proteins bind cAMP with high affinity comparable to PKA. Presently, their biochemical activity is poorly understood. However, mutational analysis in animal models as well as the disease phenotype observed in patients carrying missense mutations suggests that POPDC proteins are acting by modulating membrane trafficking of interacting proteins. In this review, we will describe the current knowledge about this gene family and also outline the apparent gaps in our understanding of their role in cAMP signalling and beyond.

Published
2017

119. Wool production in Dohne Merino, Dormer, Merino and South African Mutton Merino lambs.

Author

Van der Merwe, D. A., Brand, T. S., and Hoffman, L. C.

Subjects
*WOOL, *LAMBS, *MERINO sheep, *SHEEP, *GROWTH rate, *SHEEP diseases
Abstract

In this study, the wool growth of Dohne Merino, Dormer, Merino and South African Mutton Merino (SAMM) lambs reared on a feedlot diet (10.62 MJ ME/kg feed, 20.7% crude protein) was monitored from about two months old until the lambs were shorn as yearlings. The 100 cm2 patches on the left sides of the lambs were sheared monthly and the clippings were weighed to determine the wool growth rate. At approximately one year old, the lambs were shorn and the fleeces were weighed. A mid rib fleece sample was also retrieved from each lamb for quality analysis. Merino lambs presented the highest wool growth rates (12.943 g/day) and fleece weights (6.140 kg), whereas Dormer lambs exhibited the lowest values for these traits (8.487 g/day and 3.330 kg, respectively (P <0.05)). The lack of differences between Dohne Merino (9.720 g/day and 4.671 kg) and SAMM (10.553 g/day and 4.158 kg) lambs for these wool growth rate and fleece weight traits was attributed to disparities in live weight (86.8 kg and 105.2 kg, respectively (P <0.05), with heavier SAMM lambs offsetting the expected variations in fleece weight. Wool from Dohne Merino and Merino sheep had the finest fibre diameters (<21 µm), followed by SAMM wool (22-23 µm), with Dormers producing coarse wool (>27 µm). These results could be used as guidelines in sheep production to predict the income contribution of wool from these breeds. [ABSTRACT FROM AUTHOR]

Published
2020
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120. Effect of extrusion on the rumen undegradable protein fraction of lupins.

Author

Brand, T. S. and Jordaan, L.

Subjects
*LUPINES, *LUPINUS albus, *PROTEINS, *LOW temperatures, *RUMINANTS
Abstract

Lupins are highly degradable in the rumen, and do not provide enough bypass protein for highproducing ruminant animals. The effects of extrusion on dry matter (DM) and crude protein (CP) rumen degradability of Lupinus albus and Lupinus angustifolius were determined in situ. Samples of both types of lupin were extruded at maximum temperature, which reached 116 °C. Six Dohne Merino wethers fitted with rumen cannulas were used in this trial. Samples were incubated in the rumen at intervals of 0, 2, 4, 12, 36, and 48 hours. This procedure was repeated in two sheep per treatment and in three periods, giving a total of six observations for each variable. Extrusion lowered the soluble fraction of CP and increased the potential degradable fraction without affecting its rate of degradation. It also lowered the effective degradability of CP of both types of lupin by 28% at an outflow rate of 0.08% per hour. No differences were observed between types. Extrusion modified the ruminal degradation parameters and decreased effective rumen degradation, especially at faster outflow rates. Thus, the rumen undegradable protein (RUP) fraction of lupins was increased by extrusion and lupins could be used more efficiently in ruminant diets. This study showed that the benefits of extrusion could be reached at a relatively low temperature of 116 °C to reduce the possibility of heat damage. [ABSTRACT FROM AUTHOR]

Published
2020
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121. Premium lamb production of South African sheep breed types under feedlot conditions.

Author

van der Merwe, D. A., Brand, T. S., and Hoffman, L. C.

Subjects
*FEEDLOTS, *LAMBS, *SHEEP breeds, *METABOLIZABLE energy values, *BODY weight, *EWES
Abstract

An increasing number of producers opt to finish their lambs in on-farm feedlots. Therefore, detailed production information is required to implement precision finishing of lambs of different genotypes. Precision finishing monitors growth, feed intake and efficiency to optimize management. In this study, feedlot production characteristics of Dohne Merino, Dormer, Dorper, Meatmaster, Merino, Namaqua Afrikaner, and South African Mutton Merino (SAMM) lambs were evaluated. The lambs were reared in a feedlot and fed a diet with 10.41 MJ metabolizable energy (ME)/kg feed and 19.06% crude protein. Feed intake and body weight were recorded weekly from an initial weight of 30 kg until they had the subcutaneous fat cover needed to produce an A2 carcass. Subcutaneous fat was measured on the Longissimus lumborum muscle with an ultrasound scanner. Dorper, Meatmaster and Namaqua Afrikaner had the shortest rearing periods in the feedlot, and were market ready at a lower live weight (P <0.05). As a result, these lambs consumed less feed in the feedlot. Namaqua Afrikaner and Merino lambs were least efficient: 7.08 and 5.63 kg feed/kg gain, respectively. Dohne Merino, Dormer, Dorper, and Meatmaster rams and Dorper ewes were more efficient; approximately 3.58 kg feed/kg gain. Dohne Merino and Dormer rams had the highest growth rates: approximately 465 g/day. The end weights described in this study could be used as an indication for producers of the ideal slaughter weights for breeds of different maturity types. [ABSTRACT FROM AUTHOR]

Published
2020
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122. Effect of including canola meal in diets of slaughter ostriches (Struthio camelus var. domesticus).

Author

Brand, T. S., van der Merwe, J., and Hoffman, L. C.

Subjects
*OSTRICHES, *SOYBEAN meal, *ANIMAL nutrition, *SLAUGHTERING, *THYROID gland, *CANOLA, *ERECTOR spinae muscles
Abstract

Canola meal (CM) is a locally produced protein source that may be less expensive than soybean meal (SBM). This study evaluated the effects of replacing 0%, 25%, 50%, 75%, and 100% SBM with CM in diets for slaughter ostriches. The CM was added at the expense of SBM and other concentrates, with minor changes in other ingredients. Birds (n = 15 per treatment) were reared from 77 to 337 days old on the trial diets, which were supplied ad libitum for starter, grower, and finisher phases. Bodyweights and feed intake were measured during these phases. No differences (P >0.05) were found between treatments for live weight at the end of each phase, dry matter intake (DMI), average daily gain (ADG) and feed conversion ratio (FCR) over all the growth phases. Although no differences were observed in live weight at the end of each phase, the birds reared on the diet with 50% CM were heaviest at slaughter, and birds reared with 100% CM were lightest (P <0.05). Differences (P <0.05) between diets were observed for the weight at slaughter, weights of the liver and thyroid glands and the pH of the cold carcass. However, no differences (P >0.05) were observed between diets for fat pad weight, dressing percentage, and weights of thighs and Muscularis gastrocnemius. The results indicate that CM could replace SBM in the diets of slaughter ostriches without affecting production traits and slaughter yields. [ABSTRACT FROM AUTHOR]

Published
2020
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123. Predicting the growth and feed intake of Boer goats in a feedlot system.

Author

Brand, T. S., Van Der Merwe, D. A., Raffrenato, E., and Hoffman, L. C.

Subjects
*GOATS, *GOAT diseases, *METABOLIZABLE energy values, *WEIGHT gain, *LINEAR equations, *ANIMAL feeds, *LIVESTOCK growth
Abstract

This research sought to develop a mathematical model to predict the growth and feed intake of Boer goat kids destined for slaughter. Data were collected from castrated kids that were housed in individual pens and fed diets that varied in energy content (11.3, 12.0, and 12.7 MJ metabolizable energy (ME)/kg feed). Growth and feed intake were monitored weekly for 20 weeks, from the time that the kids weighed 22.2 ± 3.5 kg until they were slaughtered at 48.3 ± 0.8 kg. The linear equation (bodyweight = 0.202 age - 5.241 (R² = 0.84)) was found to predict the growth of kids between 126 and 266 days old. Correlations between expressions of intake and bodyweight were evaluated, cumulative feed intake and bodyweight being most highly correlated (r = 0.93). Linear models were developed to predict cumulative feed intake from bodyweight for goats fed each diet. Regression coefficients were compared between diets, with the slope of the equation for goats on the low energy diet (6.74 ± 0.25) being greater than that of the medium (5.80 ± 0.23) and high energy diets (5.82 ± 0.23). This indicates that goats on the medium and high energy diets gained weight more efficiently than those on the low energy diet. The results from this study can be used by goat producers to predict the growth and intake of goats and determine the ideal feedlot finishing period for optimal productivity. [ABSTRACT FROM AUTHOR]

Published
2020
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128. LGMD AUTOSOMAL RESSESSIVE AND DOMINANT

Author

Nelson, I., primary, De Ridder, W., additional, Asselbergh, B., additional, De Paepe, B., additional, Beuvin, M., additional, Ben Yaou, R., additional, Boland, A., additional, Deleuze, J., additional, Maisonobe, T., additional, Eymard, B., additional, De Bleecker, J., additional, Symoens, S., additional, Schindler, R., additional, Brand, T., additional, Töpf, A., additional, Johnson, K., additional, Straub, V., additional, De Jonghe, P., additional, Baets, J., additional, and Bonne, G., additional

Published
2018
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139. Venn Diagrams or Karnaugh Maps but Not Both. Part 2

Author

Brand, T. E. and Sherlock, A. J.

Abstract

This is the second of two articles giving examples on the use of Karnaugh Maps in solving problems in set theory and in Boolean algebra. Simplification techniques of the maps are concisely included. For Part 1, see volume 1, number 7, pp4-7, November 1972. (DT)

Published
1973

142. Sustainable reduction of antibiotic-induced antimicrobial resistance (ARena) in German ambulatory care: study protocol of a cluster randomised trial

Author

Kamradt, M., Kaufmann-Kolle, P., Andres, E., Brand, T. van den, Klingenberg, A., Glassen, K., Poss-Doering, R., Uhlmann, L., Hees, K., Weber, D., Gutscher, A., Wambach, V., Szecsenyi, J., Wensing, M., Kamradt, M., Kaufmann-Kolle, P., Andres, E., Brand, T. van den, Klingenberg, A., Glassen, K., Poss-Doering, R., Uhlmann, L., Hees, K., Weber, D., Gutscher, A., Wambach, V., Szecsenyi, J., and Wensing, M.

Abstract

Contains fulltext : 190981.pdf (publisher's version ) (Open Access), BACKGROUND: Despite many initiatives to enhance the rational use of antibiotics, there remains substantial room for improvement. The overall aim of this study is to optimise the appropriate use of antibiotics in German ambulatory care in patients with acute non-complicated infections (respiratory tract infections, such as bronchitis, sinusitis, tonsillitis and otitis media), community-acquired pneumonia and non-complicated cystitis, in order to counter the advancing antimicrobial resistance development. METHODS: A three-armed cluster randomised trial will be conducted in 14 practice networks in two German federal states (Bavaria and North Rhine-Westphalia) and an added cohort that reflects standard care. The trial is accompanied by a process evaluation. Each arm will receive a different set of implementation strategies. Arm A receives a standard set, comprising of e-learning on communication with patients and quality circles with data-based feedback for physicians, information campaigns for the public, patient information material and performance-based additional reimbursement. Arm B receives this standard set plus e-learning on communication with patients and quality circles with data-based feedback tailored for non-physician health professionals of the practice team and information material for tablet computers (culture sensitive). Arm C receives the standard set as well as a computerised decision support system and quality circles in local multidisciplinary groups. The study aims to recruit 193 practices which will provide data on 23,934 patients each year (47,867 patients in total). The outcome evaluation is based on claims data and refers to established indicators of the European Surveillance of Antimicrobial Consumption Network (ESAC-Net). Primary and secondary outcomes relate to prescribing of antibiotics, which will be analysed in multivariate regression models. The process evaluation is based on interviews with surveys among physicians, non-physician health

Published
2018

144. Verdieping Warmte en Koude uit Drinkwater

Author

Heijnen, L., Bel, N. van, Bloemendal, M., Brand, T. van den, Snip, L., Heijnen, L., Bel, N. van, Bloemendal, M., Brand, T. van den, and Snip, L.

Abstract

Drinkwater is een goede potentiële bron voor thermische energie ten behoeve van de verwarming en koeling van gebouwen. Begin 2017 zijn in Nederland ongeveer zeven systemen operationeel die thermische energie uit drinkwater halen en wordt een aantal nieuwe systemen aangelegd. Er is nog maar weinig bekend over de effecten van de temperatuursverandering ten gevolge van de energie-uitwisseling en de toepassing van een warmtewisselaar op de drinkwaterkwaliteit. Ook over de energetische en economische opbrengst van dergelijke systemen is nog veel onbekend. Voor drinkwaterbedrijven is het relevant om meer inzicht te krijgen in die risico’s omdat de opvatting is dat toepassing van WKD een positieve milieu-impact moet hebben en de drinkwaterkwaliteit nooit in gevaar mag brengen. In dit onderzoek zijn twee bestaande WKD-systemen geselecteerd voor een verdiepende studie gericht op microbiologische risico’s, economisch rendement en milieu-impact (LCA).

Published
2018

145. Milieuwinst en waterkwaliteitseffecten van thermische energie uit drinkwater

Author

Oesterholt, F., Bloemendal, M., Bel, N. van, Brand, T. van den, Oesterholt, F., Bloemendal, M., Bel, N. van, and Brand, T. van den

Abstract

Vrijwel alle drinkwaterbedrijven hebben ambities voor een klimaatneutrale bedrijfsvoering. Een aantal drinkwaterbedrijven probeert met opwekking van duurzame energie hun CO2-voetafdruk te verlagen. Een bijzondere manier van energieopwekking is de levering van thermische energie uit drinkwater, kortweg TED. Toepassing van TED moet een positieve milieu-impact hebben en de drinkwaterkwaliteit mag nooit in gevaar komen. Daarom is het voor drinkwaterbedrijven belangrijk om meer inzicht te krijgen in de risico’s van deze technologie. KWR Watercycle Research Institute heeft twee bestaande TED-systemen nader onderzocht op microbiologische risico’s, economisch rendement en milieu-impact (LCA). In dit artikel zijn de resultaten van het onderzoek kort samengevat.

Published
2018

146. Regenwater als bron voor drinkwater in Nederland : weegt milieuwinst op tegen de kosten?

Author

Hofman-Caris, R., Waal, L. de, Brand, T. van den, Aa, R. van der, Hoek, J.P. van der, Hofman-Caris, R., Waal, L. de, Brand, T. van den, Aa, R. van der, and Hoek, J.P. van der

Abstract

Veel consumenten hebben het idee dat ze hun milieu-impact kunnen verkleinen door zelf uit regenwater drinkwater te maken. We hebben een levenscyclusanalyse en een kostenberekening gemaakt voor decentrale zuivering van regenwater op het niveau van een stadswijk en een individuele woning in het buitengebied. Op wijkniveau zijn de kosten acceptabel, maar voor een individuele woning zijn ze erg hoog. De meerkosten staan niet in verhouding tot de te behalen milieuwinst. Belangrijke praktisch problemen zijn dat er in dichtbebouwde stadswijken te weinig regen valt voor alle inwoners en dat er te weinig ruimte is om een dergelijke zuivering te plaatsen.

Published
2018

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