930 results on '"Boyle, F."'
Search Results
102. End-of-life decision-making: a randomised controlled trial of a structured intervention for patients with advanced cancer: O65
- Author
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STEIN, R, SHARPE, L, CLARKE, S, GLARE, P, BOYLE, F, and DUNN, S
- Published
- 2005
103. Antitumor effects of an antibody-carboxypeptidase g2 conjugate in combination with a benzoic acid mustard prodrug
- Author
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Blakey, D. C., Valcaccia, B. E., East, S., Wright, A. F., Boyle, F. T., Springer, C. J., Burke, P. J., Melton, R. G., and Bagshawe, K. D.
- Published
- 1993
- Full Text
- View/download PDF
104. Beating the barriers: recruitment of people with intellectual disability to participate in research
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Lennox, N., Taylor, M., Rey-Conde, T., Bain, C., Purdie, D. M., and Boyle, F.
- Published
- 2005
105. Weaning practices in phenylketonuria vary between health professionals in Europe
- Author
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Pinto, A., Adams, S., Ahring, K., Allen, H., Almeida, M.F., Garcia-Arenas, D., Arslan, N., Assoun, M., Altinok, Y. Atik, Barrio-Carreras, D., Quintana, A. Belanger, Bernabei, S.M., Bontemps, C., Boyle, F., Bruni, G., Bueno-Delgado, M., Caine, G., Carvalho, R., Chrobot, A., Chyz, K., Cochrane, B., Correia, C., Corthouts, K., Daly, A., Leo, S. De, Desloovere, A., Meyer, A, Theux, A. De, Didycz, B., Dijsselhof, M.E., Dokoupil, K., Drabik, J., Dunlop, C., Eberle-Pelloth, W., Eftring, K., Ekengren, J., Errekalde, I., Evans, S., Foucart, A., Fokkema, L., Francois, L., French, M., Forssell, E., Gingell, C., Goncalves, C., Ozel, H. Gokmen, Grimsley, A., Gugelmo, G., Gyure, E., Heller, C., Hensler, R., Jardim, I., Joost, C., Jorg-Streller, M., Jouault, C., Jung, A., Kanthe, M., Koc, N., Kok, I.L., Kozanoglu, T., Kumru, B., Lang, F., Lang, K., Liegeois, I., Liguori, A., Lilje, R., Lubina, O., Manta-Vogli, P., Mayr, D., Meneses, C., Newby, C., Meyer, U., Mexia, S., Nicol, C., Och, U., Olivas, S.M., Pedron-Giner, C., Pereira, R., Plutowska-Hoffmann, K., Purves, J., Dionigi, A. Re, Reinson, K., Robert, M., Robertson, L., Rocha, J.C., Rohde, C., Rosenbaum-Fabian, S., Rossi, A, Ruiz, M., Saligova, J., Gutierrez-Sanchez, A., Schlune, A., Schulpis, K., Serrano-Nieto, J., Skarpalezou, A., Skeath, R., Slabbert, A., Straczek, K., Gizewska, M., Terry, A., Wegberg, A.M.J. van, Zuvadelli, J., MacDonald, A., Pinto, A., Adams, S., Ahring, K., Allen, H., Almeida, M.F., Garcia-Arenas, D., Arslan, N., Assoun, M., Altinok, Y. Atik, Barrio-Carreras, D., Quintana, A. Belanger, Bernabei, S.M., Bontemps, C., Boyle, F., Bruni, G., Bueno-Delgado, M., Caine, G., Carvalho, R., Chrobot, A., Chyz, K., Cochrane, B., Correia, C., Corthouts, K., Daly, A., Leo, S. De, Desloovere, A., Meyer, A, Theux, A. De, Didycz, B., Dijsselhof, M.E., Dokoupil, K., Drabik, J., Dunlop, C., Eberle-Pelloth, W., Eftring, K., Ekengren, J., Errekalde, I., Evans, S., Foucart, A., Fokkema, L., Francois, L., French, M., Forssell, E., Gingell, C., Goncalves, C., Ozel, H. Gokmen, Grimsley, A., Gugelmo, G., Gyure, E., Heller, C., Hensler, R., Jardim, I., Joost, C., Jorg-Streller, M., Jouault, C., Jung, A., Kanthe, M., Koc, N., Kok, I.L., Kozanoglu, T., Kumru, B., Lang, F., Lang, K., Liegeois, I., Liguori, A., Lilje, R., Lubina, O., Manta-Vogli, P., Mayr, D., Meneses, C., Newby, C., Meyer, U., Mexia, S., Nicol, C., Och, U., Olivas, S.M., Pedron-Giner, C., Pereira, R., Plutowska-Hoffmann, K., Purves, J., Dionigi, A. Re, Reinson, K., Robert, M., Robertson, L., Rocha, J.C., Rohde, C., Rosenbaum-Fabian, S., Rossi, A, Ruiz, M., Saligova, J., Gutierrez-Sanchez, A., Schlune, A., Schulpis, K., Serrano-Nieto, J., Skarpalezou, A., Skeath, R., Slabbert, A., Straczek, K., Gizewska, M., Terry, A., Wegberg, A.M.J. van, Zuvadelli, J., and MacDonald, A.
- Abstract
Contains fulltext : 205374.pdf (publisher's version ) (Open Access), Background: In phenylketonuria (PKU), weaning is considered more challenging when compared to feeding healthy infants. The primary aim of weaning is to gradually replace natural protein from breast milk or standard infant formula with solids containing equivalent phenylalanine (Phe). In addition, a Phe-free second stage L-amino acid supplement is usually recommended from around 6months to replace Phe-free infant formula. Our aim was to assess different weaning approaches used by health professionals across Europe. Methods: A cross sectional questionnaire (survey monkey(R)) composed of 31 multiple and single choice questions was sent to European colleagues caring for inherited metabolic disorders (IMD). Centres were grouped into geographical regions for analysis. Results: Weaning started at 17-26weeks in 85% (n=81/95) of centres, >26weeks in 12% (n=11/95) and<17weeks in 3% (n=3/95). Infant's showing an interest in solid foods, and their age, were important determinant factors influencing weaning commencement. 51% (n=48/95) of centres introduced Phe containing foods at 17-26weeks and 48% (n=46/95) at >26weeks. First solids were mainly low Phe vegetables (59%, n=56/95) and fruit (34%, n=32/95).A Phe exchange system to allocate dietary Phe was used by 52% (n=49/95) of centres predominantly from Northern and Southern Europe and 48% (n=46/95) calculated most Phe containing food sources (all centres in Eastern Europe and the majority from Germany and Austria). Some centres used a combination of both methods.A second stage Phe-free L-amino acid supplement containing a higher protein equivalent was introduced by 41% (n=39/95) of centres at infant age 26-36weeks (mainly from Germany, Austria, Northern and Eastern Europe) and 37% (n=35/95) at infant age>1y mainly from Southern Europe. 53% (n=50/95) of centres recommended a second stage Phe-free L-amino acid supplement in a spoonable or semi-solid form. Conclusions: Weaning strategies vary throughout European PKU centres. There
- Published
- 2019
106. Phase 1 trial of olaparib and oral cyclophosphamide in BRCA breast cancer, recurrent BRCA ovarian cancer, non-BRCA triple-negative breast cancer, and non-BRCA ovarian cancer
- Author
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Lee, CK, Scott, C, Lindeman, GJ, Hamilton, A, Lieschke, E, Gibbs, E, Asher, R, Badger, H, Paterson, R, Macnab, L, Kwan, EM, Francis, PA, Boyle, F, Friedlander, M, Lee, CK, Scott, C, Lindeman, GJ, Hamilton, A, Lieschke, E, Gibbs, E, Asher, R, Badger, H, Paterson, R, Macnab, L, Kwan, EM, Francis, PA, Boyle, F, and Friedlander, M
- Abstract
BACKGROUND: We conducted a Phase 1 study to evaluate safety and activity of olaparib tablets and oral cyclophosphamide. METHODS: Patients had metastatic breast cancer (BC) or recurrent high-grade serous ovarian cancer (HGSOC), performance status 0-2, and ≤3 lines of prior therapy. Patients were treated using a dose escalation strategy with cohort expansion once maximal tolerated dose (MTD) was determined. Dose level 1 (DL1): olaparib 300 mg bid, cyclophosphamide 50 mg on days 1, 3, and 5, weekly. DL2: olaparib 300 mg bid, cyclophosphamide 50 mg, days 1-5 weekly. RESULTS: Of 32 patients, 23 had HGSOC (germline BRCA mutation [gBRCAm] 70%) and 9 had BC (gBRCAm 67%). Four were treated at DL1 and 28 at DL2, the MTD. Haematological adverse events (AEs) were most common: grade 3/4 AEs: lymphopenia 75%, anaemia 31%, neutropenia 37%, thrombocytopenia 47%. Two permanently discontinued treatment due to haematological AEs. In BC, no objective response was reported. Unconfirmed objective response was 48% and 64% for all HGSOC and gBRCAm subset, respectively. CA125 responses were 70% (all HGSOC) and 92% (gBRCAm). CONCLUSIONS: In HGSOC and BC, olaparib 300 mg bid and cyclophosphamide 50 mg on days 1-5 weekly were tolerable and active, particularly in gBRCAm, and is worthy of further investigation.
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- 2019
107. Weaning practices in phenylketonuria vary between health professionals in Europe.
- Author
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UCL - (SLuc) Service d'endocrinologie et de nutrition, Pinto, A, Adams, S, Ahring, K, Allen, H, Almeida, M F, Garcia-Arenas, D, Arslan, N, Assoun, M, Atik Altınok, Y, Barrio-Carreras, D, Belanger Quintana, A, Bernabei, S M, Bontemps, C, Boyle, F, Bruni, G, Bueno-Delgado, M, Caine, G, Carvalho, R, Chrobot, A, Chyż, K, Cochrane, B, Correia, C, Corthouts, K, Daly, A, De Leo, S, Desloovere, A, De Meyer, A, De Theux, A, Didycz, B, Dijsselhof, M E, Dokoupil, K, Drabik, J, Dunlop, C, Eberle-Pelloth, W, Eftring, K, Ekengren, J, Errekalde, I, Evans, S, Foucart, Audrey, Fokkema, L, François, L, French, M, Forssell, E, Gingell, C, Gonçalves, C, Gökmen Özel, H, Grimsley, A, Gugelmo, G, Gyüre, E, Heller, C, Hensler, R, Jardim, I, Joost, C, Jörg-Streller, M, Jouault, C, Jung, A, Kanthe, M, Koç, N, Kok, I L, Kozanoğlu, T, Kumru, B, Lang, F, Lang, K, Liegeois, I, Liguori, A, Lilje, R, Ļubina, O, Manta-Vogli, P, Mayr, D, Meneses, C, Newby, C, Meyer, U, Mexia, S, Nicol, C, Och, U, Olivas, S M, Pedrón-Giner, C, Pereira, R, Plutowska-Hoffmann, K, Purves, J, Re Dionigi, A, Reinson, K, Robert, M, Robertson, L, Rocha, J C, Rohde, C, Rosenbaum-Fabian, S, Rossi, A, Ruiz, M, Saligova, J, Gutiérrez-Sánchez, A, Schlune, A, Schulpis, K, Serrano-Nieto, J, Skarpalezou, A, Skeath, R, Slabbert, A, Straczek, K, Giżewska, M, Terry, A, Thom, R, Tooke, A, Tuokkola, J, van Dam, E, van den Hurk, T A M, van der Ploeg, E M C, Vande Kerckhove, K, Van Driessche, M, van Wegberg, A M J, van Wyk, K, Vasconcelos, C, Velez García, V, Wildgoose, J, Winkler, T, Żółkowska, J, Zuvadelli, J, MacDonald, A, UCL - (SLuc) Service d'endocrinologie et de nutrition, Pinto, A, Adams, S, Ahring, K, Allen, H, Almeida, M F, Garcia-Arenas, D, Arslan, N, Assoun, M, Atik Altınok, Y, Barrio-Carreras, D, Belanger Quintana, A, Bernabei, S M, Bontemps, C, Boyle, F, Bruni, G, Bueno-Delgado, M, Caine, G, Carvalho, R, Chrobot, A, Chyż, K, Cochrane, B, Correia, C, Corthouts, K, Daly, A, De Leo, S, Desloovere, A, De Meyer, A, De Theux, A, Didycz, B, Dijsselhof, M E, Dokoupil, K, Drabik, J, Dunlop, C, Eberle-Pelloth, W, Eftring, K, Ekengren, J, Errekalde, I, Evans, S, Foucart, Audrey, Fokkema, L, François, L, French, M, Forssell, E, Gingell, C, Gonçalves, C, Gökmen Özel, H, Grimsley, A, Gugelmo, G, Gyüre, E, Heller, C, Hensler, R, Jardim, I, Joost, C, Jörg-Streller, M, Jouault, C, Jung, A, Kanthe, M, Koç, N, Kok, I L, Kozanoğlu, T, Kumru, B, Lang, F, Lang, K, Liegeois, I, Liguori, A, Lilje, R, Ļubina, O, Manta-Vogli, P, Mayr, D, Meneses, C, Newby, C, Meyer, U, Mexia, S, Nicol, C, Och, U, Olivas, S M, Pedrón-Giner, C, Pereira, R, Plutowska-Hoffmann, K, Purves, J, Re Dionigi, A, Reinson, K, Robert, M, Robertson, L, Rocha, J C, Rohde, C, Rosenbaum-Fabian, S, Rossi, A, Ruiz, M, Saligova, J, Gutiérrez-Sánchez, A, Schlune, A, Schulpis, K, Serrano-Nieto, J, Skarpalezou, A, Skeath, R, Slabbert, A, Straczek, K, Giżewska, M, Terry, A, Thom, R, Tooke, A, Tuokkola, J, van Dam, E, van den Hurk, T A M, van der Ploeg, E M C, Vande Kerckhove, K, Van Driessche, M, van Wegberg, A M J, van Wyk, K, Vasconcelos, C, Velez García, V, Wildgoose, J, Winkler, T, Żółkowska, J, Zuvadelli, J, and MacDonald, A
- Abstract
BACKGROUND: In phenylketonuria (PKU), weaning is considered more challenging when compared to feeding healthy infants. The primary aim of weaning is to gradually replace natural protein from breast milk or standard infant formula with solids containing equivalent phenylalanine (Phe). In addition, a Phe-free second stage L-amino acid supplement is usually recommended from around 6 months to replace Phe-free infant formula. Our aim was to assess different weaning approaches used by health professionals across Europe. METHODS: A cross sectional questionnaire (survey monkey®) composed of 31 multiple and single choice questions was sent to European colleagues caring for inherited metabolic disorders (IMD). Centres were grouped into geographical regions for analysis. RESULTS: Weaning started at 17-26 weeks in 85% (n = 81/95) of centres, >26 weeks in 12% (n = 11/95) and < 17 weeks in 3% (n = 3/95). Infant's showing an interest in solid foods, and their age, were important determinant factors influencing weaning commencement. 51% (n = 48/95) of centres introduced Phe containing foods at 17-26 weeks and 48% (n = 46/95) at >26 weeks. First solids were mainly low Phe vegetables (59%, n = 56/95) and fruit (34%, n = 32/95).A Phe exchange system to allocate dietary Phe was used by 52% (n = 49/95) of centres predominantly from Northern and Southern Europe and 48% (n = 46/95) calculated most Phe containing food sources (all centres in Eastern Europe and the majority from Germany and Austria). Some centres used a combination of both methods.A second stage Phe-free L-amino acid supplement containing a higher protein equivalent was introduced by 41% (n = 39/95) of centres at infant age 26-36 weeks (mainly from Germany, Austria, Northern and Eastern Europe) and 37% (n = 35/95) at infant age > 1y mainly from Southern Europe. 53% (n = 50/95) of centres recommended a second stage Phe-free L-amino acid supplement in a spoonable or semi-solid form. CONCLUSIONS: Weaning strategies vary throu
- Published
- 2019
108. Beyond the headlines: Fetal movement awareness is an important stillbirth prevention strategy
- Author
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Flenady, V, Ellwood, D, Bradford, B, Coory, M, Middleton, P, Gardener, G, Radestad, I, Homer, C, Davies-Tuck, M, Forster, D, Gordon, A, Groom, K, Crowther, C, Walker, S, Foord, C, Warland, J, Murphy, M, Said, J, Boyle, F, O'Donoghue, K, Cronin, R, Sexton, J, Weller, M, McCowan, L, Flenady, V, Ellwood, D, Bradford, B, Coory, M, Middleton, P, Gardener, G, Radestad, I, Homer, C, Davies-Tuck, M, Forster, D, Gordon, A, Groom, K, Crowther, C, Walker, S, Foord, C, Warland, J, Murphy, M, Said, J, Boyle, F, O'Donoghue, K, Cronin, R, Sexton, J, Weller, M, and McCowan, L
- Published
- 2019
109. A phase III wait-listed randomised controlled trial of novel targeted inter-professional clinical education intervention to improve cancer patients' reported pain outcomes (The Cancer Pain Assessment (CPAS) Trial): Study protocol
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Phillips, JL, Heneka, N, Lovell, M, Lam, L, Davidson, P, Boyle, F, McCaffrey, N, Fielding, S, Shaw, T, Phillips, JL, Heneka, N, Lovell, M, Lam, L, Davidson, P, Boyle, F, McCaffrey, N, Fielding, S, and Shaw, T
- Abstract
© 2019 The Author(s). Background: Variations in care models contribute to cancer pain being under-recognised and under-treated in half of all patients with cancer. International and national cancer pain management guidelines are achievable with minimal investment but require practice changes. While much of the cancer pain research over the preceding decades has focused on management interventions, little attention has been given to achieving better adherence to recommended cancer pain guideline screening and assessment practices. This trial aims to reduce unrelieved cancer pain by improving cancer and palliative doctors' and nurses' ('clinicians') pain assessment capabilities through a targeted inter-professional clinical education intervention delivered to participants' mobile devices ('mHealth'). Methods: A wait-listed, randomised control trial design. Cancer and/or palliative care physicians and nurses employed at one of the six participating sites across Australia will be eligible to participate in this trial and, on enrolment, will be allocated to the active or wait-listed arm. Participants allocated to the active arm will be invited to complete the mHealth cancer pain assessment intervention. In this trial, mHealth is defined as medical or public health practice supported by mobile devices (i.e. phones, patient monitoring devices, personal digital assistants and other wireless devices). This mHealth intervention integrates three evidence-based elements, namely: the COM-B theoretical framework; spaced learning pedagogy; and audit and feedback. This intervention will be delivered via the QStream online platform to participants' mobile devices over four weeks. The trial will determine if a tailored mHealth intervention, targeting clinicians' cancer pain assessment capabilities, is effective in reducing self-reported cancer pain scores, as measured by a Numerical Rating Scale (NRS). Discussion: If this mHealth intervention is found to be effective, in addition to
- Published
- 2019
110. Screening and Audit as Service-Level Strategies to Support Implementation of Australian Guidelines for Cancer Pain Management in Adults: A Feasibility Study
- Author
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Lovell, M, Birch, MR, Luckett, T, Phillips, J, Davidson, PM, Agar, M, Boyle, F, Lovell, M, Birch, MR, Luckett, T, Phillips, J, Davidson, PM, Agar, M, and Boyle, F
- Abstract
© 2019 Background: Pain in people with cancer is common but often under-recognized and under-treated. Guidelines can improve the quality of pain care, but need targeted strategies to support implementation. Aim: To test the feasibility of two service-level strategies for supporting guideline implementation: a screening system and medical record audit. Design: Multimethods. Setting: One oncology outpatient service, and one palliative care outpatient and inpatient service. Participants: Patients with advanced cancer. Methods: Patients were screened in the waiting room with a modified version of the Edmonton Symptom Assessment System-revised either electronically or in paper-based format. Feasibility indicated the percentage of patients successfully screened from the total number attending the services. An audit assessed adherence to key indicators of pain assessment and management. Feasibility thresholds were set at 75% incidence for screening and a median of 30 minutes per patient for audit. Results: Of 452 patient visits, 95% (n = 429)were successfully screened, 34% (n = 155)electronically and 61% (n = 274)paper-based. Electronic pain screening was technically challenging and time-intensive for nurses. Thirty-one patients consented to have their records audited. The median audit time was 37.5 minutes (range 10-120 minutes). Variability arose from the number and type of record (outpatient or inpatient). Adherence to indicators varied from 63% (pain assessment at first presentation)to 94% (regular pain assessment and medication prescribed at regular intervals). Conclusions: This study confirmed the need to implement evidence-based guidelines for cancer pain and generated useful insights into the feasibility of pain screening and audit.
- Published
- 2019
111. Change in Blood Pressure Variability Among Treated Elderly Hypertensive Patients and Its Association With Mortality
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Chowdhury, Enayet, Nelson, M.R., Wing, L.M.H., Jennings, G.L.R., Beilin, L.J., Reid, Christopher, Bruce, A., Beckinsale, P., Thompson, J., McMurchie, M., Fraser, G., Gleave, D., Cope, V., DeLooze, F., Moore, S., Dibben, C., Newbury, J., McDermott, B., Willson, K., Bear, C., Harrap, S., Johnston, C., Ryan, P., Brown, M., Fletcher, P., Feneley, M., Dewar, E., Marley, J., Moss, J., Webb, P., Glasziou, P., Boyle, F., Primrose, J., Piterman, L., De Looze, F., Dickinson, J., Gambrill, J., Joseph, P., Donnan, G., Morgan, T., Whitworth, J., MacMahon, S., Silagy, C., Chowdhury, Enayet, Nelson, M.R., Wing, L.M.H., Jennings, G.L.R., Beilin, L.J., Reid, Christopher, Bruce, A., Beckinsale, P., Thompson, J., McMurchie, M., Fraser, G., Gleave, D., Cope, V., DeLooze, F., Moore, S., Dibben, C., Newbury, J., McDermott, B., Willson, K., Bear, C., Harrap, S., Johnston, C., Ryan, P., Brown, M., Fletcher, P., Feneley, M., Dewar, E., Marley, J., Moss, J., Webb, P., Glasziou, P., Boyle, F., Primrose, J., Piterman, L., De Looze, F., Dickinson, J., Gambrill, J., Joseph, P., Donnan, G., Morgan, T., Whitworth, J., MacMahon, S., and Silagy, C.
- Abstract
Background: Information is scarce regarding effects of antihypertensive medication on blood pressure variability (BPV) and associated clinical outcomes. We examined whether antihypertensive treatment changes BPV over time and whether such change (decline or increase) has any association with long-term mortality in an elderly hypertensive population. Methods and Results: We used data from a subset of participants in the Second Australian National Blood Pressure study (n=496) aged ≥65 years who had 24-hour ambulatory blood pressure recordings at study entry (baseline) and then after a median of 2 years while on treatment (follow-up). Weighted day-night systolic BPV was calculated for both baseline and follow-up as a weighted mean of daytime and nighttime blood pressure standard deviations. The annual rate of change in BPV over time was calculated from these BPV estimates. Furthermore, we classified both BPV estimates as high and low based on the baseline median BPV value and then classified BPV changes into stable: low BPV, stable: high BPV, decline: high to low, and increase: low to high. We observed an annual decline (mean±SD: −0.37±1.95; 95% CI, −0.54 to −0.19; P<0.001) in weighted day-night systolic BPV between baseline and follow-up. Having constant stable: high BPV was associated with an increase in all-cause mortality (hazard ratio: 3.03; 95% CI, 1.67–5.52) and cardiovascular mortality (hazard ratio: 3.70; 95% CI, 1.62–8.47) in relation to the stable: low BPV group over a median 8.6 years after the follow-up ambulatory blood pressure monitoring. Similarly, higher risk was observed in the decline: high to low group. Conclusions: Our results demonstrate that in elderly hypertensive patients, average BPV declined over 2 years of follow-up after initiation of antihypertensive therapy, and having higher BPV (regardless of any change) was associated with increased long-term mortality.
- Published
- 2019
112. Better health literacy
- Author
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Ostini, R., Kairuz, T., Summers, J., Swinburne, G., Boyle, F., Emmerton, Lynne, Duncan, G., Ostini, R., Kairuz, T., Summers, J., Swinburne, G., Boyle, F., Emmerton, Lynne, and Duncan, G.
- Published
- 2019
113. Pain Management
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Boyle, F. M., primary and Grossman, S. A., additional
- Published
- 1999
- Full Text
- View/download PDF
114. ZD9331
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Boyle, F. Thomas, primary, Stephens, Trevor C., additional, Averbuch, S. D., additional, and Jackman, Ann L., additional
- Published
- 1999
- Full Text
- View/download PDF
115. Present interest gifts in trust: donor and donee problems.
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Boyle, F. Ladson
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Crummey trusts -- Laws, regulations and rules - Published
- 1994
116. Couple distress after sudden infant or perinatal death: A 30-month follow up
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VANCE, J C, BOYLE, F M, NAJMAN, J M, and THEARLE, M J
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- 2002
117. Trastuzumab (Herceptin)
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Boyle, F
- Published
- 2001
118. The Antitumour Activity of ZD9331, a Non-Polyglutamatable Quinazoline Thymidylate Synthase Inhibitor
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Jackman, Ann L., primary, Kimbell, Rosemary, additional, Brown, Melody, additional, Brunton, Lisa, additional, Harrap, Kenneth R., additional, Wardleworth, J. Michael, additional, and Boyle, F. Thomas, additional
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- 1995
- Full Text
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119. Breast cancer survivors. -letter
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Boyle, F and Forbes, J
- Published
- 2008
120. Weaning practices in phenylketonuria vary between health professionals in Europe
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Pinto, A., primary, Adams, S., additional, Ahring, K., additional, Allen, H., additional, Almeida, M.F., additional, Garcia-Arenas, D., additional, Arslan, N., additional, Assoun, M., additional, Atik Altınok, Y., additional, Barrio-Carreras, D., additional, Belanger Quintana, A., additional, Bernabei, S.M., additional, Bontemps, C., additional, Boyle, F., additional, Bruni, G., additional, Bueno-Delgado, M., additional, Caine, G., additional, Carvalho, R., additional, Chrobot, A., additional, Chyż, K., additional, Cochrane, B., additional, Correia, Carla, additional, Corthouts, K., additional, Daly, A., additional, De Leo, S., additional, Desloovere, A., additional, De Meyer, A., additional, De Theux, A., additional, Didycz, B., additional, Dijsselhof, M.E., additional, Dokoupil, K., additional, Drabik, J., additional, Dunlop, C., additional, Eberle-Pelloth, W., additional, Eftring, K., additional, Ekengren, J., additional, Errekalde, I., additional, Evans, S., additional, Foucart, A., additional, Fokkema, L., additional, François, L., additional, French, M., additional, Forssell, E., additional, Gingell, C., additional, Gonçalves, C., additional, Gökmen Özel, H., additional, Grimsley, A., additional, Gugelmo, G., additional, Gyüre, E., additional, Heller, C., additional, Hensler, R., additional, Jardim, I., additional, Joost, C., additional, Jörg-Streller, M., additional, Jouault, C., additional, Jung, A., additional, Kanthe, M., additional, Koç, N., additional, Kok, I.L., additional, Kozanoğlu, T., additional, Kumru, B., additional, Lang, F., additional, Lang, K., additional, Liegeois, I., additional, Liguori, A., additional, Lilje, R., additional, Ļubina, O., additional, Manta-Vogli, P., additional, Mayr, D., additional, Meneses, C., additional, Newby, C., additional, Meyer, U., additional, Mexia, S., additional, Nicol, C., additional, Och, U., additional, Olivas, S.M., additional, Pedrón-Giner, C., additional, Pereira, R., additional, Plutowska-Hoffmann, K., additional, Purves, J., additional, Re Dionigi, A., additional, Reinson, K., additional, Robert, M., additional, Robertson, L., additional, Rocha, J.C., additional, Rohde, C., additional, Rosenbaum-Fabian, S., additional, Rossi, A., additional, Ruiz, M., additional, Saligova, J., additional, Gutiérrez-Sánchez, A., additional, Schlune, A., additional, Schulpis, K., additional, Serrano-Nieto, J., additional, Skarpalezou, A., additional, Skeath, R., additional, Slabbert, A., additional, Straczek, K., additional, Giżewska, M., additional, Terry, A., additional, Thom, R., additional, Tooke, A., additional, Tuokkola, J., additional, van Dam, E., additional, van den Hurk, T.A.M., additional, van der Ploeg, E.M.C., additional, Vande Kerckhove, K., additional, Van Driessche, M., additional, van Wegberg, A.M.J., additional, van Wyk, K., additional, Vasconcelos, C., additional, Velez García, V., additional, Wildgoose, J., additional, Winkler, T., additional, Żółkowska, J., additional, Zuvadelli, J., additional, and MacDonald, A., additional
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- 2019
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121. Structure-Teratogenicity Relationships Among Antifungal Triazoles
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Flint, Oliver P., primary and Boyle, F. Thomas, additional
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- 1990
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122. Drug Discovery: A Chemist’s Approach
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Boyle, F. Thomas, primary
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- 1990
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123. Early feeding practices in infants with phenylketonuria across Europe
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Pinto, A., Adams, S., Ahring, K., Allen, H., Almeida, M. F., Garcia-Arenas, D., Arslan, N., Assoun, M., Atik Altınok, Y., Barrio-Carreras, D., Belanger Quintana, A., Bernabei, S. M., Bontemps, C., Boyle, F., Bruni, G., Bueno-Delgado, M., Caine, G., Carvalho, R., Chrobot, A., Chyż, K., Cochrane, B., Correia, C., Corthouts, K., Daly, A., De Leo, S., Desloovere, A., De Meyer, A., De Theux, A., Didycz, B., Dijsselhof, M. E., Dokoupil, K., Drabik, J., Dunlop, C., Eberle-Pelloth, W., Eftring, K., Ekengren, J., Errekalde, I., Evans, S., Foucart, A., Fokkema, L., François, L., French, M., Forssell, E., Gingell, C., Gonçalves, C., Gökmen Özel, H., Grimsley, A., Gugelmo, G., Gyüre, E., Heller, C., Hensler, R., Jardim, I., Joost, C., Jörg-Streller, M., Jouault, C., Jung, A., Kanthe, M., Koç, N., Kok, I. L., Kozanoğlu, T., Kumru, B., Lang, F., Lang, K., Liegeois, I., Liguori, A., Lilje, R., Ļubina, O., Manta-Vogli, P., Mayr, D., Meneses, C., Newby, C., Meyer, U., Mexia, S., Nicol, C., Och, U., Olivas, S. M., Pedrón-Giner, C., Pereira, R., Plutowska-Hoffmann, K., Purves, J., Re Dionigi, A., Reinson, K., Robert, M., Robertson, L., Rocha, J. C., Rohde, C., Rosenbaum-Fabian, S., Rossi, A., Ruiz, M., Saligova, J., Gutiérrez-Sánchez, A., Schlune, A., Schulpis, K., Serrano-Nieto, J., Skarpalezou, A., Skeath, R., Slabbert, A., Straczek, K., Giżewska, M., Terry, A., Thom, R., Tooke, A., Tuokkola, J., van Dam, E., van den Hurk, T. A.M., van der Ploeg, E. M.C., Vande Kerckhove, K., Van Driessche, M., van Wegberg, A. M.J., van Wyk, K., Vasconcelos, C., Velez García, V., Wildgoose, J., Winkler, T., Żółkowska, J., Zuvadelli, J., MacDonald, A., Pinto, A., Adams, S., Ahring, K., Allen, H., Almeida, M. F., Garcia-Arenas, D., Arslan, N., Assoun, M., Atik Altınok, Y., Barrio-Carreras, D., Belanger Quintana, A., Bernabei, S. M., Bontemps, C., Boyle, F., Bruni, G., Bueno-Delgado, M., Caine, G., Carvalho, R., Chrobot, A., Chyż, K., Cochrane, B., Correia, C., Corthouts, K., Daly, A., De Leo, S., Desloovere, A., De Meyer, A., De Theux, A., Didycz, B., Dijsselhof, M. E., Dokoupil, K., Drabik, J., Dunlop, C., Eberle-Pelloth, W., Eftring, K., Ekengren, J., Errekalde, I., Evans, S., Foucart, A., Fokkema, L., François, L., French, M., Forssell, E., Gingell, C., Gonçalves, C., Gökmen Özel, H., Grimsley, A., Gugelmo, G., Gyüre, E., Heller, C., Hensler, R., Jardim, I., Joost, C., Jörg-Streller, M., Jouault, C., Jung, A., Kanthe, M., Koç, N., Kok, I. L., Kozanoğlu, T., Kumru, B., Lang, F., Lang, K., Liegeois, I., Liguori, A., Lilje, R., Ļubina, O., Manta-Vogli, P., Mayr, D., Meneses, C., Newby, C., Meyer, U., Mexia, S., Nicol, C., Och, U., Olivas, S. M., Pedrón-Giner, C., Pereira, R., Plutowska-Hoffmann, K., Purves, J., Re Dionigi, A., Reinson, K., Robert, M., Robertson, L., Rocha, J. C., Rohde, C., Rosenbaum-Fabian, S., Rossi, A., Ruiz, M., Saligova, J., Gutiérrez-Sánchez, A., Schlune, A., Schulpis, K., Serrano-Nieto, J., Skarpalezou, A., Skeath, R., Slabbert, A., Straczek, K., Giżewska, M., Terry, A., Thom, R., Tooke, A., Tuokkola, J., van Dam, E., van den Hurk, T. A.M., van der Ploeg, E. M.C., Vande Kerckhove, K., Van Driessche, M., van Wegberg, A. M.J., van Wyk, K., Vasconcelos, C., Velez García, V., Wildgoose, J., Winkler, T., Żółkowska, J., Zuvadelli, J., and MacDonald, A.
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- 2018
124. Madarosis: a qualitative study to assess perceptions and experience of Australian patients with early breast cancer treated with taxane-based chemotherapy.
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Antill Y.C., Smith K., Winstanley J., Boyle F., O'Reilly A., White M., Antill Y.C., Smith K., Winstanley J., Boyle F., O'Reilly A., and White M.
- Abstract
Purpose: Eyebrow and eyelash loss (madarosis) is a common and distressing side effect of chemotherapy for which no protective strategies have yet been developed. The purpose of this study was to develop an overview of perceptions and experiences of women undergoing taxane-based treatment for early breast cancer. Method(s): A total of 25 women with a diagnosis of invasive early breast cancer participated in a focus group (n = 5), ages ranging from 35 to 64 (median 50), all had completed therapy with a taxane-based chemotherapy treatment. This focus group used targeted questions to explore participants' perceptions and experience of madarosis during and following chemotherapy and identified issues associated with impact of madarosis on quality of life (QoL). Thematic analysis was conducted to identify important issues experienced by participants. Result(s): Seven themes emerged from the data: (1) timing of regrowth and permanent changes, (2) meaning/importance of eyebrow/eyelashes, (3) preparedness/information given, (4) impact of the hair loss of self, (5) impact of hair loss on others, (6) physiological side effects of loss of eyebrows/eyelashes, and (7) management of loss of eyebrows/eyelashes. In addition, participants noted physical symptoms of eye irritation during their treatment that they attributed to madarosis. Conclusion(s): This study highlights the significant impact of madarosis on patients, providing the first published analysis of patient's attitude and perception of eyelash and eyebrow loss during chemotherapy. Further research in this area is required and will be benefitted from the development of a dedicated instrument/questionnaire that can capture and measure the impact of madarosis on QoL and allow development of clinical trial strategies.Copyright © 2017, Springer-Verlag GmbH Germany.
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- 2018
125. Care in subsequent pregnancies following stillbirth : an international survey of parents
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Wojcieszek, A. M., Boyle, F. M., Belizán, J. M., Cassidy, J., Cassidy, P., Erwich, J. J. H. M., Farrales, L., Gross, M. M., Heazell, A. E. P., Leisher, S. H., Mills, T., Murphy, M., Pettersson, K., Ravaldi, C., Ruidiaz, J., Siassakos, D., Silver, R. M., Storey, C., Vannacci, A., Middleton, P., Ellwood, D., Flenady, V., Wojcieszek, A. M., Boyle, F. M., Belizán, J. M., Cassidy, J., Cassidy, P., Erwich, J. J. H. M., Farrales, L., Gross, M. M., Heazell, A. E. P., Leisher, S. H., Mills, T., Murphy, M., Pettersson, K., Ravaldi, C., Ruidiaz, J., Siassakos, D., Silver, R. M., Storey, C., Vannacci, A., Middleton, P., Ellwood, D., and Flenady, V.
- Abstract
Objective: To assess the frequency of additional care, and parents' perceptions of quality, respectful care, in pregnancies subsequent to stillbirth. Design: Multi‐language web‐based survey. Setting: International. Population: A total of 2716 parents, from 40 high‐ and middle‐income countries. Methods: Data were obtained from a broader survey of parents' experiences following stillbirth. Data were analysed using descriptive statistics and stratified by geographic region. Subgroup analyses explored variation in additional care by gestational age at index stillbirth. Main outcome measures: Frequency of additional care, and perceptions of quality, respectful care. Results: The majority (66%) of parents conceived their subsequent pregnancy within 1 year of stillbirth. Additional antenatal care visits and ultrasound scans were provided for 67% and 70% of all parents, respectively, although there was wide variation across geographic regions. Care addressing psychosocial needs was less frequently provided, such as additional visits to a bereavement counsellor (10%) and access to named care provider's phone number (27%). Compared with parents whose stillbirth occurred at ≤ 29 weeks of gestation, parents whose stillbirth occurred at ≥ 30 weeks of gestation were more likely to receive various forms of additional care, particularly the option for early delivery after 37 weeks. Around half (47-63%) of all parents felt that elements of quality, respectful care were consistently applied, such as spending enough time with parents and involving parents in decision‐making. Conclusions: Greater attention is required to providing thoughtful, empathic and collaborative care in all pregnancies following stillbirth. Specific education and training for health professionals is needed.
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- 2018
126. Health care experiences among women diagnosed with gestational breast cancer
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Hammarberg, K, Sullivan, E, Javid, N, Duncombe, G, Halliday, L, Boyle, F, Saunders, C, Ives, A, Dickinson, JE, Fisher, J, Hammarberg, K, Sullivan, E, Javid, N, Duncombe, G, Halliday, L, Boyle, F, Saunders, C, Ives, A, Dickinson, JE, and Fisher, J
- Abstract
© 2017 John Wiley & Sons Ltd Gestational breast cancer (GBC) presents many challenges for women and the clinicians who care for them. The aim of this study was to explore the health care experiences of women diagnosed with GBC to inform and improve clinical care of women in this predicament. Semi-structured interviews were conducted with 17 women who had been diagnosed with GBC in the previous 5 years. The overarching themes for perceived quality of care were “communication” and “comprehensive care.” “Communication” had two sub themes: “interdisciplinary communication” (the way health professionals from different disciplines communicated with each other about the management of the woman's care) and “patient communication” (how they communicated this to the woman). The “comprehensive care” theme incorporated three sub themes: “the spirit” (psychological care); “the mind” (information provision); and “the body” (management of treatment side effects). Women's own accounts of positive and negative experiences of GBC care provide unique and specific insights which improve understanding of their concerns and needs. The findings can inform advances in quality and efficacy of clinical care; offer guidance for obstetricians, oncologists and allied health professionals about the needs of women diagnosed with GBC and how care can be optimised; and inform the development of resources to assist women and their families.
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- 2018
127. Early feeding practices in infants with phenylketonuria across Europe
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Afdeling Dietetiek, Other research (not in main researchprogram), Pinto, A., Adams, S., Ahring, K., Allen, H., Almeida, M. F., Garcia-Arenas, D., Arslan, N., Assoun, M., Atik Altınok, Y., Barrio-Carreras, D., Belanger Quintana, A., Bernabei, S. M., Bontemps, C., Boyle, F., Bruni, G., Bueno-Delgado, M., Caine, G., Carvalho, R., Chrobot, A., Chyż, K., Cochrane, B., Correia, C., Corthouts, K., Daly, A., De Leo, S., Desloovere, A., De Meyer, A., De Theux, A., Didycz, B., Dijsselhof, M. E., Dokoupil, K., Drabik, J., Dunlop, C., Eberle-Pelloth, W., Eftring, K., Ekengren, J., Errekalde, I., Evans, S., Foucart, A., Fokkema, L., François, L., French, M., Forssell, E., Gingell, C., Gonçalves, C., Gökmen Özel, H., Grimsley, A., Gugelmo, G., Gyüre, E., Heller, C., Hensler, R., Jardim, I., Joost, C., Jörg-Streller, M., Jouault, C., Jung, A., Kanthe, M., Koç, N., Kok, I. L., Kozanoğlu, T., Kumru, B., Lang, F., Lang, K., Liegeois, I., Liguori, A., Lilje, R., Ļubina, O., Manta-Vogli, P., Mayr, D., Meneses, C., Newby, C., Meyer, U., Mexia, S., Nicol, C., Och, U., Olivas, S. M., Pedrón-Giner, C., Pereira, R., Plutowska-Hoffmann, K., Purves, J., Re Dionigi, A., Reinson, K., Robert, M., Robertson, L., Rocha, J. C., Rohde, C., Rosenbaum-Fabian, S., Rossi, A., Ruiz, M., Saligova, J., Gutiérrez-Sánchez, A., Schlune, A., Schulpis, K., Serrano-Nieto, J., Skarpalezou, A., Skeath, R., Slabbert, A., Straczek, K., Giżewska, M., Terry, A., Thom, R., Tooke, A., Tuokkola, J., van Dam, E., van den Hurk, T. A.M., van der Ploeg, E. M.C., Vande Kerckhove, K., Van Driessche, M., van Wegberg, A. M.J., van Wyk, K., Vasconcelos, C., Velez García, V., Wildgoose, J., Winkler, T., Żółkowska, J., Zuvadelli, J., MacDonald, A., Afdeling Dietetiek, Other research (not in main researchprogram), Pinto, A., Adams, S., Ahring, K., Allen, H., Almeida, M. F., Garcia-Arenas, D., Arslan, N., Assoun, M., Atik Altınok, Y., Barrio-Carreras, D., Belanger Quintana, A., Bernabei, S. M., Bontemps, C., Boyle, F., Bruni, G., Bueno-Delgado, M., Caine, G., Carvalho, R., Chrobot, A., Chyż, K., Cochrane, B., Correia, C., Corthouts, K., Daly, A., De Leo, S., Desloovere, A., De Meyer, A., De Theux, A., Didycz, B., Dijsselhof, M. E., Dokoupil, K., Drabik, J., Dunlop, C., Eberle-Pelloth, W., Eftring, K., Ekengren, J., Errekalde, I., Evans, S., Foucart, A., Fokkema, L., François, L., French, M., Forssell, E., Gingell, C., Gonçalves, C., Gökmen Özel, H., Grimsley, A., Gugelmo, G., Gyüre, E., Heller, C., Hensler, R., Jardim, I., Joost, C., Jörg-Streller, M., Jouault, C., Jung, A., Kanthe, M., Koç, N., Kok, I. L., Kozanoğlu, T., Kumru, B., Lang, F., Lang, K., Liegeois, I., Liguori, A., Lilje, R., Ļubina, O., Manta-Vogli, P., Mayr, D., Meneses, C., Newby, C., Meyer, U., Mexia, S., Nicol, C., Och, U., Olivas, S. M., Pedrón-Giner, C., Pereira, R., Plutowska-Hoffmann, K., Purves, J., Re Dionigi, A., Reinson, K., Robert, M., Robertson, L., Rocha, J. C., Rohde, C., Rosenbaum-Fabian, S., Rossi, A., Ruiz, M., Saligova, J., Gutiérrez-Sánchez, A., Schlune, A., Schulpis, K., Serrano-Nieto, J., Skarpalezou, A., Skeath, R., Slabbert, A., Straczek, K., Giżewska, M., Terry, A., Thom, R., Tooke, A., Tuokkola, J., van Dam, E., van den Hurk, T. A.M., van der Ploeg, E. M.C., Vande Kerckhove, K., Van Driessche, M., van Wegberg, A. M.J., van Wyk, K., Vasconcelos, C., Velez García, V., Wildgoose, J., Winkler, T., Żółkowska, J., Zuvadelli, J., and MacDonald, A.
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- 2018
128. Development and pilot testing of a Decision Aid (DA) for women with early-stage breast cancer considering contralateral prophylactic mastectomy
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Ager, B, Jansen, J, Porter, D, Phillips, KA, Glassey, R, Rankin, N, Musiello, T, Boyle, F, Zdenkowski, N, Skandarajah, A, Saunders, C, Sundaresan, P, De Abreu Lourenco, R, Butow, P, Ager, B, Jansen, J, Porter, D, Phillips, KA, Glassey, R, Rankin, N, Musiello, T, Boyle, F, Zdenkowski, N, Skandarajah, A, Saunders, C, Sundaresan, P, De Abreu Lourenco, R, and Butow, P
- Abstract
© 2018 Elsevier Ltd Objective: Describe the development, acceptability and feasibility of a Decision Aid (DA) for women with early-stage breast cancer (BC) at average contralateral breast cancer (CBC) risk considering contralateral prophylactic mastectomy (CPM). Methods: The DA was developed using the International Patient Decision Aid Standards (IPDAS) and the Ottawa Decision Support Framework. It provides evidence-based information about CPM in a booklet format combining text, graphs and images of surgical options. Twenty-three women with a history of early-stage breast cancer were interviewed in person or over the phone using a ‘think aloud approach’. Framework analysis was used to code and analyse data. Results: Twenty-three women participated in the study. Mean age of participants was 58.6 years and time since diagnosis ranged from 14 months to 21 years. Five women had CPM and eighteen had not. Women strongly endorsed the DA. Many felt validated by a section on appearance and found information on average risk of recurrence and metastases helpful, however, noted the importance of discussing personal risk with their surgeon. Many requested more information on surgery details (time taken, recovery) and costs of the different options. Conclusion: The DA was acceptable to women, including the format, content and proposed implementation strategies. Practical and financial issues are important to women in considering treatment options. Practice implications: Women appreciate information about CPM at diagnosis and emphasised the importance of discussing potential downsides of the procedure in addition to benefits. The DA was considered acceptable to facilitate such discussions.
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- 2018
129. Accreditation Standard Guideline Initiative for Tai Chi and Qigong Instructors and Training Institutions.
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Oh, B, Yeung, A, Klein, P, Larkey, L, Ee, C, Zaslawski, C, Knobf, T, Payne, P, Stener-Victorin, E, Lee, R, Choi, W, Chun, M, Bonucci, M, Lang, H-D, Pavlakis, N, Boyle, F, Clarke, S, Back, M, Yang, P, Wei, Y, Guo, X, Weng, C-HD, Irwin, MR, Elfiky, AA, Rosenthal, D, Oh, B, Yeung, A, Klein, P, Larkey, L, Ee, C, Zaslawski, C, Knobf, T, Payne, P, Stener-Victorin, E, Lee, R, Choi, W, Chun, M, Bonucci, M, Lang, H-D, Pavlakis, N, Boyle, F, Clarke, S, Back, M, Yang, P, Wei, Y, Guo, X, Weng, C-HD, Irwin, MR, Elfiky, AA, and Rosenthal, D
- Abstract
Evidence of the health and wellbeing benefits of Tai Chi and Qigong (TQ) have emerged in the past two decades, but TQ is underutilized in modern health care in Western countries due to lack of promotion and the availability of professionally qualified TQ instructors. To date, there are no government regulations for TQ instructors or for training institutions in China and Western countries, even though TQ is considered to be a part of Traditional Chinese medicine that has the potential to manage many chronic diseases. Based on an integrative health care approach, the accreditation standard guideline initiative for TQ instructors and training institutions was developed in collaboration with health professionals, integrative medicine academics, Tai Chi and Qigong master instructors and consumers including public safety officers from several countries, such as Australia, Canada, China, Germany, Italy, Korea, Sweden and USA. In this paper, the rationale for organizing the Medical Tai Chi and Qigong Association (MTQA) is discussed and the accreditation standard guideline for TQ instructors and training institutions developed by the committee members of MTQA is presented. The MTQA acknowledges that the proposed guidelines are broad, so that the diversity of TQ instructors and training institutions can be integrated with recognition that these guidelines can be developed with further refinement. Additionally, these guidelines face challenges in understanding the complexity of TQ associated with different principles, philosophies and schools of thought. Nonetheless, these guidelines represent a necessary first step as primary resource to serve and guide health care professionals and consumers, as well as the TQ community.
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- 2018
130. Protocol for a phase III pragmatic stepped wedge cluster randomised controlled trial comparing the effectiveness and cost-effectiveness of screening and guidelines with, versus without, implementation strategies for improving pain in adults with cancer attending outpatient oncology and palliative care services: The Stop Cancer PAIN trial
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Luckett, T, Phillips, J, Agar, M, Lam, L, Davidson, PM, McCaffrey, N, Boyle, F, Shaw, T, Currow, DC, Read, A, Hosie, A, Lovell, M, Luckett, T, Phillips, J, Agar, M, Lam, L, Davidson, PM, McCaffrey, N, Boyle, F, Shaw, T, Currow, DC, Read, A, Hosie, A, and Lovell, M
- Abstract
© 2018 The Author(s). Background: Pain is a common and distressing symptom in people with cancer, but is under-recognised and under-treated. Australian guidelines for 'Cancer Pain Management in Adults' are available on the Cancer Council Australia Cancer Guideline Wiki. This study aims to evaluate the effectiveness and cost-effectiveness of a suite of guideline implementation strategies for improving pain outcomes in adults with cancer in oncology and palliative care outpatient settings. Methods: The study will use a stepped-wedge cluster randomised controlled design, with oncology and palliative care outpatient services as the clusters. Patients will be eligible if they are adults with cancer and pain presenting to participating services during the study period. During an initial control arm, services will routinely screen patients for average and worst pain over the past 24 h using a 0-10 numerical rating scale (NRS) and have unfettered access to online guidelines. During the intervention arm, staff at each service will be encouraged to use: 1) a patient education booklet and self-management resource; 2) an online spaced learning cancer pain education module for clinicians from different disciplines; and 3) audit and feedback of service performance on key indices of cancer pain screening, assessment and management. Service-based clinical change champions will lead implementation of these strategies. The trial's primary outcome will be the probability that patients initially screened as having moderate-severe (≥5/10 NRS) worst pain experience a clinically important improvement one week later, defined as ≥ 30% reduction. Secondary outcomes will include patient empowerment and quality of life, carer experience, and cost-effectiveness. For the main analysis, linear mixed models will be used, accounting for clustering and the longitudinal design. Eighty-two patients per service at six services (N = 492) will provide > 90% power. A qualitative sub-study and analyses of
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- 2018
131. Implementation and evaluation of a quality improvement initiative to reduce late gestation stillbirths in Australia: Safer Baby Bundle study protocol.
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Andrews, C. J., Ellwood, D., Middleton, P. F., Gordon, A., Nicholl, M., Homer, C. S. E., Morris, J., Gardener, G., Coory, M., Davies-Tuck, M., Boyle, F. M., Callander, E., Bauman, A., Flenady, V. J., and Safer Baby Bundle collaborators
- Subjects
PREGNANCY ,STILLBIRTH ,MOTHERHOOD ,MATERNAL health services - Abstract
Background: In 2015, the stillbirth rate after 28 weeks (late gestation) in Australia was 35% higher than countries with the lowest rates globally. Reductions in late gestation stillbirth rates have steadily improved in Australia. However, to amplify and sustain reductions, more needs to be done to reduce practice variation and address sub-optimal care. Implementing bundles for maternity care improvement in the UK have been associated with a 20% reduction in stillbirth rates. A similar approach is underway in Australia; the Safer Baby Bundle (SBB) with five elements: 1) supporting women to stop smoking in pregnancy, 2) improving detection and management of fetal growth restriction, 3) raising awareness and improving care for women with decreased fetal movements, 4) improving awareness of maternal safe going-to-sleep position in late pregnancy, 5) improving decision making about the timing of birth for women with risk factors for stillbirth.Methods: This is a mixed-methods study of maternity services across three Australian states; Queensland, Victoria and New South Wales. The study includes evaluation of 'targeted' implementer sites (combined total approximately 113,000 births annually, 50% of births in these states) and monitoring of key outcomes state-wide across all maternity services. Progressive implementation over 2.5 years, managed by state Departments of Health, commenced from mid-2019. This study will determine the impact of implementing the SBB on maternity services and perinatal outcomes, specifically for reducing late gestation stillbirth. Comprehensive process, impact, and outcome evaluations will be conducted using routinely collected perinatal data, pre- and post- implementation surveys, clinical audits, focus group discussions and interviews. Evaluations explore the views and experiences of clinicians embedding the SBB into routine practice as well as women's experience with care and the acceptability of the initiative.Discussion: This protocol describes the evaluation of the SBB initiative and will provide evidence for the value of a systematic, but pragmatic, approach to strategies to reduce the evidence-practice gaps across maternity services. We hypothesise successful implementation and uptake across three Australian states (amplified nationally) will be effective in reducing late gestation stillbirths to that of the best performing countries globally, equating to at least 150 lives saved annually.Trial Registration: The Safer Baby Bundle Study was retrospectively registered on the ACTRN12619001777189 database, date assigned 16/12/2019. [ABSTRACT FROM AUTHOR]- Published
- 2020
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132. New anti-cancer drugs: out of the black hole and coming to a clinic near you
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Boyle, F
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- 2001
133. Health care experiences among women diagnosed with gestational breast cancer
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Hammarberg, K, Sullivan, E, Javid, N, Duncombe, G, Halliday, L, Boyle, F, Saunders, C, Ives, A, Dickinson, JE, and Fisher, J
- Subjects
Adult ,Pregnancy ,Delivery of Health Care, Integrated ,Communication ,Humans ,Breast Neoplasms ,Interdisciplinary Communication ,Female ,Oncology & Carcinogenesis ,Professional-Patient Relations ,Middle Aged ,Qualitative Research ,Quality of Health Care - Abstract
© 2017 John Wiley & Sons Ltd Gestational breast cancer (GBC) presents many challenges for women and the clinicians who care for them. The aim of this study was to explore the health care experiences of women diagnosed with GBC to inform and improve clinical care of women in this predicament. Semi-structured interviews were conducted with 17 women who had been diagnosed with GBC in the previous 5 years. The overarching themes for perceived quality of care were “communication” and “comprehensive care.” “Communication” had two sub themes: “interdisciplinary communication” (the way health professionals from different disciplines communicated with each other about the management of the woman's care) and “patient communication” (how they communicated this to the woman). The “comprehensive care” theme incorporated three sub themes: “the spirit” (psychological care); “the mind” (information provision); and “the body” (management of treatment side effects). Women's own accounts of positive and negative experiences of GBC care provide unique and specific insights which improve understanding of their concerns and needs. The findings can inform advances in quality and efficacy of clinical care; offer guidance for obstetricians, oncologists and allied health professionals about the needs of women diagnosed with GBC and how care can be optimised; and inform the development of resources to assist women and their families.
- Published
- 2017
134. P008 - Patients’ quality of life and side effect perceptions in monarchE, a study of abemaciclib plus endocrine therapy in adjuvant treatment of HR+, HER2-, node-positive, high-risk, early breast cancer
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Tolaney, S., Blancas, I., Im, Y.-H., Rastogi, P., Brown, J., Shahir, A., Zimmermann, A., and Boyle, F.
- Published
- 2021
- Full Text
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135. Parents’ and healthcare professionals’ experiences of care after stillbirth in low‐ and middle‐income countries: a systematic review and meta‐summary
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Shakespeare, C, primary, Merriel, A, additional, Bakhbakhi, D, additional, Baneszova, R, additional, Barnard, K, additional, Lynch, M, additional, Storey, C, additional, Blencowe, H, additional, Boyle, F, additional, Flenady, V, additional, Gold, K, additional, Horey, D, additional, Mills, T, additional, and Siassakos, D, additional
- Published
- 2018
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136. Early feeding practices in infants with phenylketonuria across Europe
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Pinto, A., primary, Adams, S., additional, Ahring, K., additional, Allen, H., additional, Almeida, M.F., additional, Garcia-Arenas, D., additional, Arslan, N., additional, Assoun, M., additional, Atik Altınok, Y., additional, Barrio-Carreras, D., additional, Belanger Quintana, A., additional, Bernabei, S.M., additional, Bontemps, C., additional, Boyle, F., additional, Bruni, G., additional, Bueno-Delgado, M., additional, Caine, G., additional, Carvalho, R., additional, Chrobot, A., additional, Chyż, K., additional, Cochrane, B., additional, Correia, C., additional, Corthouts, K., additional, Daly, A., additional, De Leo, S., additional, Desloovere, A., additional, De Meyer, A., additional, De Theux, A., additional, Didycz, B., additional, Dijsselhof, M.E., additional, Dokoupil, K., additional, Drabik, J., additional, Dunlop, C., additional, Eberle-Pelloth, W., additional, Eftring, K., additional, Ekengren, J., additional, Errekalde, I., additional, Evans, S., additional, Foucart, A., additional, Fokkema, L., additional, François, L., additional, French, M., additional, Forssell, E., additional, Gingell, C., additional, Gonçalves, C., additional, Gökmen Özel, H., additional, Grimsley, A., additional, Gugelmo, G., additional, Gyüre, E., additional, Heller, C., additional, Hensler, R., additional, Jardim, I., additional, Joost, C., additional, Jörg-Streller, M., additional, Jouault, C., additional, Jung, A., additional, Kanthe, M., additional, Koç, N., additional, Kok, I.L., additional, Kozanoğlu, T., additional, Kumru, B., additional, Lang, F., additional, Lang, K., additional, Liegeois, I., additional, Liguori, A., additional, Lilje, R., additional, Ļubina, O., additional, Manta-Vogli, P., additional, Mayr, D., additional, Meneses, C., additional, Newby, C., additional, Meyer, U., additional, Mexia, S., additional, Nicol, C., additional, Och, U., additional, Olivas, S.M., additional, Pedrón-Giner, C., additional, Pereira, R., additional, Plutowska-Hoffmann, K., additional, Purves, J., additional, Re Dionigi, A., additional, Reinson, K., additional, Robert, M., additional, Robertson, L., additional, Rocha, J.C., additional, Rohde, C., additional, Rosenbaum-Fabian, S., additional, Rossi, A., additional, Ruiz, M., additional, Saligova, J., additional, Gutiérrez-Sánchez, A., additional, Schlune, A., additional, Schulpis, K., additional, Serrano-Nieto, J., additional, Skarpalezou, A., additional, Skeath, R., additional, Slabbert, A., additional, Straczek, K., additional, Giżewska, M., additional, Terry, A., additional, Thom, R., additional, Tooke, A., additional, Tuokkola, J., additional, van Dam, E., additional, van den Hurk, T.A.M., additional, van der Ploeg, E.M.C., additional, Vande Kerckhove, K., additional, Van Driessche, M., additional, van Wegberg, A.M.J., additional, van Wyk, K., additional, Vasconcelos, C., additional, Velez García, V., additional, Wildgoose, J., additional, Winkler, T., additional, Żółkowska, J., additional, Zuvadelli, J., additional, and MacDonald, A., additional
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- 2018
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137. Abstract P1-15-01: Final analysis of SWOG S0230/Prevention of early menopause study (POEMS)
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Moore, HCF, primary, Unger, JM, additional, Phillips, K-A, additional, Boyle, F, additional, Hitre, E, additional, Moseley, A, additional, Porter, D, additional, Francis, PA, additional, Goldstein, LJ, additional, Gomez, HL, additional, Vallejos, CS, additional, Partridge, AH, additional, Dakhil, SR, additional, Garcia, AA, additional, Gralow, J, additional, Lombard, JM, additional, Forbes, JF, additional, Martino, S, additional, Barlow, WE, additional, Fabian, CJ, additional, Minasian, L, additional, Meyskens, FL, additional, Gelber, RD, additional, Hortobagyi, GN, additional, and Albain, KS, additional
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- 2018
- Full Text
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138. International validation of the European Organisation for Research and Treatment of Cancer QLQ-BRECON23 quality-of-life questionnaire for women undergoing breast reconstruction
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Winters, Z E, primary, Afzal, M, additional, Rutherford, C, additional, Holzner, B, additional, Rumpold, G, additional, da Costa Vieira, R A, additional, Hartup, S, additional, Flitcroft, K, additional, Bjelic-Radisic, V, additional, Oberguggenberger, A, additional, Panouilleres, M, additional, Mani, M, additional, Catanuto, G, additional, Douek, M, additional, Kokan, J, additional, Sinai, P, additional, King, M T, additional, Spillane, A, additional, Snook, K, additional, Boyle, F, additional, French, J, additional, Elder, E, additional, Chalmers, B, additional, Kabir, M, additional, Campbell, I, additional, Wong, A, additional, Flay, H, additional, Scarlet, J, additional, Weis, J, additional, Giesler, J, additional, Bliem, B, additional, Nagele, E, additional, del Angelo, N, additional, Andrade, V, additional, Assump¸ão Garcia, D, additional, Bonnetain, F, additional, Kjelsberg, M, additional, William-Jones, S, additional, Fleet, A, additional, Hathaway, S, additional, Elliott, J, additional, Galea, M, additional, Dodge, J, additional, Chaudhy, A, additional, Williams, R, additional, Cook, L, additional, Sethi, S, additional, Turton, P, additional, Henson, A, additional, Gibb, J, additional, Bonomi, R, additional, Funnell, S, additional, Noren, C, additional, Ooi, J, additional, Cocks, S, additional, Dawson, L, additional, Patel, H, additional, Bailey, L, additional, Chatterjee, S, additional, Goulden, K, additional, Kirk, S, additional, Osborne, W, additional, Harter, L, additional, Sharif, M A, additional, Corcoran, S, additional, Smith, J, additional, Prasad, R, additional, Doran, A, additional, Power, A, additional, Devereux, L, additional, Cannon, J, additional, Latham, S, additional, Arora, P, additional, Ridgway, S, additional, Coulding, M, additional, Roberts, R, additional, Absar, M, additional, Hodgkiss, T, additional, Connolly, K, additional, Johnson, J, additional, Doyle, K, additional, Lunt, N, additional, Cooper, M, additional, Fuchs, I, additional, Peall, L, additional, Taylor, L, additional, and Nicholson, A, additional
- Published
- 2017
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139. Nitrate Nutrition and Temperature Effects on Wheat: a Synthesis of Plant Growth and Nitrogen Uptake in Relation to Metabolic and Physiological Processes
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LAWLOR, D. W., BOYLE, F. A., KEYS, A. J., KENDALL, A. C., and YOUNG, A. T.
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- 1988
140. Nitrate Nutrition and Temperature Effects on Wheat: Enzyme Composition, Nitrate and Total Amino Acid Content of Leaves
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LAWLOR, D. W., BOYLE, F. A., KENDALL, A. C., and KEYS, A. J.
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- 1987
141. Nitrate Nutrition and Temperature Effects on Wheat: Photosynthesis and Photorespiration of Leaves
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LAWLOR, D. W., BOYLE, F. A., YOUNG, A. T., KEYS, A. J., and KENDALL, A. C.
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- 1987
142. Nitrate Nutrition and Temperature Effects on Wheat: Soluble Components of Leaves and Carbon Fluxes to Amino Acids and Sucrose
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LAWLOR, D. W., BOYLE, F. A., YOUNG, A. T., KENDALL, A. C., and KEYS, A. J.
- Published
- 1987
143. Neurophysiological and clinical outcomes in chemotherapy-induced neuropathy in cancer
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Kandula, T, Farrar, MA, Kiernan, MC, Krishnan, AV, Goldstein, D, Horvath, L, Grimison, P, Boyle, F, Baron-Hay, S, Park, SB, Kandula, T, Farrar, MA, Kiernan, MC, Krishnan, AV, Goldstein, D, Horvath, L, Grimison, P, Boyle, F, Baron-Hay, S, and Park, SB
- Abstract
Chemotherapy induced peripheral neuropathy (CIPN) is a significant toxicity of cancer treatment, with the potential to affect long-term function and quality of life in cancer survivors. There remains a lack of consensus around optimal assessment techniques. While current approaches to CIPN assessment are focused on clinical grading scales, it is becoming increasingly evident that a more comprehensive multimodal assessment package is necessary to accurately characterise the impact of CIPN as well as gauge the utility of neuroprotective mechanisms. Neurophysiological techniques provide objective biomarkers and may enable early detection of toxicity while patient reported outcomes are necessary to determine the significance of symptoms to individual patients. In addition to providing an objective assessment, clinical neurophysiological techniques provide important insights into the contributory pathophysiological mechanisms of CIPN with different chemotherapy agents. There is a paucity of implementation of these techniques in the clinical trial setting. The present Review aims to facilitate the use of neurophysiological studies as part of comprehensive assessment packages for the monitoring of CIPN by summarising current understanding of neurophysiological changes that underlie the development of neuropathy, clinical presentations and patient reported outcomes as well as advantages and limitations of current techniques for the neurophysiological assessment of CIPN.
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- 2017
144. Eyelash and eyebrow madarosis: A qualitative study to assess the perceptions and experience of Australian patients with breast cancer.
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White M., Morris K., Winstanley J., Boyle F., O'Reily A., Antill Y., White M., Morris K., Winstanley J., Boyle F., O'Reily A., and Antill Y.
- Abstract
Introduction: Chemotherapy-induced eyebrow and eyelash loss (madarosis) is a common and distressing side effect experienced by women undergoing treatment for breast cancer. Objective(s): To explore patient's perceptions and experience of madarosis during and after chemotherapy and identify issues associated with the impact of madarosis on quality of life (QOL) as a first step towards developing a new QOL tool. Method(s): Women with a diagnosis of invasive breast cancer, who had completed adjuvant chemotherapy, were invited to participate in a guided focus group. The groups (lead by one investigator KM), explored perceptions and experiences of madarosis, discussed using targeted questions. Thematic analysis was conducted to identify important issues experienced by patients. Result(s): 25 women participated in one of five groups, ages ranging from 35-64 (median 50). All had completed adjuvant therapy with a minimum of four cycles of Taxane-based treatment. Seven themes emerged from the data: (1) Meaning and importance of eyebrows/eyelashes (2) Preparedness/Information provided (3) Impact of hair loss on[Fself (4) Impact of hair loss on others (5) Physiological side effects of loss of eyebrows/eyelashes (6) Management of loss of eyebrows/eyelashes and (7) Timing of regrowth and permanent changes. A range of emotional issues caused by madarosis were reported, together with side effects of dry eyes, excessive tearing and soreness/redness. Conclusion(s): This study highlights the significant impact of madarosis on patients, both emotionally and physiologically. Further research in this area is needed and interventional trials will benefit from development of a dedicated instrument/questionnaire which captures and measures the impact of madarosis on QOL.
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- 2017
145. Determining breast cancer recurrence following completion of active treatment: A novel approach using linked administrative health data.
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Preen, D, Kemp-Casey, A, Roughead, E, Lopez, D, Bulsara, M, Boyle, F, Saunders, C, Preen, D, Kemp-Casey, A, Roughead, E, Lopez, D, Bulsara, M, Boyle, F, and Saunders, C
- Abstract
ObjectivesAlthough outcomes for the majority of women diagnosed with primary breast cancer are good, with five-year survival exceeding 90%, some women will experience cancer recurrence and ultimately die from the disease. It is important for patients, clinicians and health service planners to know the risk of recurrence once initial treatment for primary breast cancer is completed. However, none of Australia’s State or Territory cancer registries routinely report on cancer recurrence which could be used to evaluate this issue. To address this absence of direct reporting, we aimed to determine the incidence of cancer recurrence in Australian clinical practice after completion of treatment for primary breast cancer, using a range of linked health data sources. ApproachWe performed a retrospective cohort study using linked health data from New South Wales (NSW), Australia. Data were linked from six data collections: i) Cancer Registry, ii) Admitted Patient Data Collection, iii) Pharmaceutical Benefits Scheme claims, iv) Medicare (outpatient) claims, v) Death Registry; and the vi) NSW 45 and Up Study. We identified 2416 women diagnosed with primary invasive breast cancer during 2003-2008 in NSW who had not had a recurrence by 18 months post-diagnosis. Unit-level hospital, pharmacy and outpatient claims were used to identify services indicative of recurrence. Incidence of recurrence was calculated and multivariate Cox regression used to identify baseline and active treatment characteristics predictive of cancer recurrence up to six years post-diagnosis. ResultsA total of 217 women (9.0%) had a hospital, pharmacy or outpatient claim indicating breast cancer recurrence between 18 months and six years post-diagnosis. Overall annual cumulative incidence of recurrence was 3.3%. Recurrence was significantly higher for women with node-positive (4.8% vs. 2.5% annually, adjHR=1.7, 95%CI=1.3-2.3) or hormone receptor-negative (3.8% vs. 3.1% annually, adjHR=1.3
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- 2017
146. Translating Research into Community Practice: The Healthy Living after Cancer Partnership Project
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Eakin, E, Hayes, S, Reeves, M, Goode, A, Vardy, J, Boyle, F, Haas, M, Hiller, J, Mishra, G, Jefford, M, Koczwara, B, Saunders, C, Chapman, K, Boltong, A, Lane, K, Baldwin, P, Robertson, A, Millar, L, McKiernan, S, Demark-Wahnefried, W, Courneya, K, Robson, E, Eakin, E, Hayes, S, Reeves, M, Goode, A, Vardy, J, Boyle, F, Haas, M, Hiller, J, Mishra, G, Jefford, M, Koczwara, B, Saunders, C, Chapman, K, Boltong, A, Lane, K, Baldwin, P, Robertson, A, Millar, L, McKiernan, S, Demark-Wahnefried, W, Courneya, K, and Robson, E
- Published
- 2017
147. A Case of Opioid Toxicity on Conversion From Extended-Release Oxycodone and Naloxone to Extended-Release Oxycodone in a Patient With Liver Dysfunction.
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Franklin, AE, Lovell, MR, Boyle, F, Franklin, AE, Lovell, MR, and Boyle, F
- Published
- 2017
148. Turbulent Skin Friction of Dilute Polymer Solutions in Rough Pipes
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Brandt, H., McDonald, A. T., Boyle, F. W., and Wells, C. Sinclair, editor
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- 1969
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149. Health care experiences among women diagnosed with gestational breast cancer
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Hammarberg, K., primary, Sullivan, E., additional, Javid, N., additional, Duncombe, G., additional, Halliday, L., additional, Boyle, F., additional, Saunders, C., additional, Ives, A., additional, Dickinson, J.E., additional, and Fisher, J., additional
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- 2017
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150. Patients’ experiences and perspectives of multiple concurrent symptoms in advanced cancer: a semi-structured interview study
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Dong, ST, Butow, PN, Tong, A, Agar, M, Boyle, F, Forster, BC, Stockler, M, and Lovell, MR
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Self Care ,Male ,Neoplasms ,Palliative Care ,Humans ,Female ,Oncology & Carcinogenesis ,Aged - Abstract
© 2015, Springer-Verlag Berlin Heidelberg. Purpose: Patients with advanced cancer typically experience multiple concurrent symptoms, which have a detrimental impact on patient outcomes. No studies to date have qualitatively explored advanced cancer patients’ perceptions of multiple symptoms in oncology and palliative care settings. Understanding the experience of multiple symptoms can inform integrated clinical pathways for treating, assessing and reducing symptom burden. This study aims to describe the beliefs, attitudes and experiences of patients with multiple symptoms in advanced cancer. Methods: Semi-structured interviews were conducted with 58 advanced cancer patients (23 inpatients and 35 outpatients), recruited purposively from two palliative care centres and two hospital-based oncology departments in Sydney, Australia. Transcripts were analysed thematically. Results: Six major themes were identified: imminence of death and deterioration (impending death, anticipatory fear); overwhelming loss of control (symptom volatility, debilitating exhaustion, demoralisation, isolation); impinging on autonomy and identity (losing independence, refusal to a diminished self, self-advocacy, reluctance to burden others); psychological adaptation (accepting the impossibility of recovery, seeking distractions, maintaining hope, mindfulness, accommodating self-limitations), burden of self-management responsibility (perpetual self-monitoring, ambiguity in self-report, urgency of decision making, optimising management); and valuing security and empowerment (safety in coordinated care, compassionate care, fear of medical abandonment, dependence on social support). Patients transitioning from oncology to palliative care settings were more vulnerable to self-management burden. Conclusion: Multiple symptoms have a profound impact on patients’ autonomy, function and psychological state. Multiple symptom management and integrated care is needed to empower advanced cancer patients and reduce their struggles with self-management burden, hopelessness, isolation, fear of abandonment and mortality anxieties.
- Published
- 2015
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