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У статті досліджується сучасний стан робочого місця викладача закладу вищої освіти в умовах дистанційного навчання та віддаленої роботи, що спричинено перш за все пандемією COVID-19 і введенням воєнного стану в Україні, який оголошено після повномасштабного воєнного вторгнення рф. Зокрема, аналізується нормативно-правове забезпечення діяльності викладачів у дистанційному освітньому середовищі. Виокремлено ключові аспекти, які визначають особливості організації робочого місця викладача закладу вищої освіти в умовах дистанційного навчання, такі як: технічне забезпечення; організація освітнього процесу; психологічні аспекти; нормативно-правові гарантії тощо. Зазначено, що впровадження дистанційного навчання «знецінило» попередню роботу із насиченням закладів освіти, зокрема – закладів вищої освіти комп’ютерною технікою та підключенням комунікацій, перш за все орієнтованих на використання в режимі фізичної присутності в приміщеннях ЗВО. Також акцентовано увагу на проблемі забезпечення фізичної безпеки викладачів ЗВО і здобувачів вищої освіти та їх термінового дистанційного навчання ключових основ освітнього процесу, орієнтованого на те, що Міжнародна організація стандартизації (ISO) називає спільною діяльністю (Collaborative activities), яку забезпечують спільні робочі місця (Collaborative workplace). Послідовно викладено положення міжнародних стандартів, так і норми національного законодавства, що регулюють вимоги та гарантії організації робочого місця викладача ЗВО за ієрархічною структурою. Підкреслено, що регулювання професійної діяльності викладача ЗВО при виконанні дистанційної роботи на рівні норм законів більш-менш вирішено, то запровадження підзаконних документів та локальних актів ЗВО, які регламентують дистанційне навчання є неприпустимо повільним та шкодить якості вищої освіти. Відзначено, що українське законодавство та практика його застосування при дистанційному навчанні, залишили здобувачів вищої освіти та викладачів ЗВО наодинці щодо необхідності забезпечення безпечних та ефективних умов у нових реаліях. Бракує рекомендацій щодо організації та оснащення робочого місця здобувача вищої освіти. Зазначене у певному демпфірується творчими практиками викладачів ЗВО. Зроблено висновок, що головною причиною інтенсивного розвитку системи дистанційного навчання в Україні є його інтеграційна спроможність, а п’ятирічний український досвід проведення дистанційного навчання в особливих умовах вимагає більш швидкого державного регулювання цієї форми освіти та проведення відповідних академічних досліджень тощо.

PurposeDeveloping innovative precision and personalized cancer therapeutics is essential to enhance cancer survivability, particularly for prevalent cancer types such as colorectal cancer. This study aims to demonstrate various approaches for discovering new targets for precision therapies using artificial intelligence (AI) on a Polish cohort of colorectal cancer patients. MethodsWe analyzed 71 patients with histopathologically confirmed advanced resectional colorectal adenocarcinoma. Whole exome sequencing was performed on tumor and peripheral blood samples, while RNA sequencing (RNAseq) was conducted on tumor samples. We employed three approaches to identify potential targets for personalized and precision therapies. First, using our in-house neoantigen calling pipeline, ARDentify, combined with an AI-based model trained on immunopeptidomics mass spectrometry data (ARDisplay), we identified neoepitopes in the cohort. Second, based on recurrent mutations found in our patient cohort, we selected corresponding cancer cell lines and utilized knock-out gene dependency scores to identify synthetic lethality genes. Third, an AI-based model trained on cancer cell line data was employed to identify cell lines with genomic profiles similar to selected patients. Copy number variants and recurrent single nucleotide variants in these cell lines, along with gene dependency data, were used to find personalized synthetic lethality pairs. ResultsWe identified approximately 8,700 unique neoepitopes, but none were shared by more than two patients, indicating limited potential for shared neoantigenic targets across our cohort. Additionally, we identified three synthetic lethality pairs: the well-known APC-CTNNB1 and BRAF-DUSP4 pairs, along with the recently described APC-TCF7L2 pair, which could be significant for patients with APC and BRAF variants. Furthermore, by leveraging the identification of similar cancer cell lines, we uncovered a potential gene pair, VPS4A and VPS4B, with therapeutic implications. ConclusionOur study highlights three distinct approaches for identifying potential therapeutic targets in cancer patients. Each approach yielded valuable insights into our cohort, underscoring the relevance and utility of these methodologies in the development of precision and personalized cancer therapies. Importantly, we developed a novel AI model that aligns tumors with representative cell lines using RNAseq and methylation data. This model enables us to identify cell lines closely resembling patient tumors, facilitating accurate selection of models needed for in vitro validation.

It is common knowledge that no signals having the form of a sequence of weighted Dirac deltas, as they are currently modelled so, are present, in reality, at the output of analog-to-digital converters (ADC). No such signals are available in the otherwise large variety of physical signals. This has been illustrated in many works and shown by means of measurements. However, it is highly intriguing that the same papers (with the exception of this article) consider it necessary to model the signals at the output of ADC via sequences of Dirac deltas because only such an approach allows to describe the aliasing effect occurring in the spectra of these signals. But due to this incorrect description such an approach is obviously incomprehensible to everyone. In accepting this, however, it has been overlooked that this does not have to be the case at all. The effect of aliasing in the spectrum of a sampled signal may be explained by modeling this signal as a weighted step function. Moreover, such an approach offers also a quantitatively more accurate result for this spectrum than the one obtained using the current method. All that is illustrated in this paper that focuses on this specific theme.

The use of information technologies, in particular virtual reality (VR), is becoming a topical issue in the professional training of natural science teachers. The study aims to assess the effectiveness of a professional development program that utilizes virtual reality as an educational tool to enhance the quality of training for natural science teachers. The obtained results testify to the positive impact of the VR use on various aspects of teachers’ professional training. The study found that the attitude towards technology improved significantly after the VR introduction (from 65% to 72%). The percentage of positive responses regarding the feasibility of using STEM (Science, Technology, Engineering and Mathematics) technologies in education increased by 25%. Student feedback emphasizes the importance of integrating new technologies into STEM education. Further research should examine the training needs of STEM teachers in different educational contexts, explore effective technology integration strategies, and assess their impact on student outcomes.

The paper discusses the possibility of using groundwater as a source of water supply for Mykolaiv during emergencies or military operations. A hydrogeological model of the Mykolaiv groundwater field was developed to investigate the water exchange pattern and sources of operational groundwater reserves in the Upper Sarmatian aquifer, which is a primary source of drinking groundwater in the Mykolaiv area. The influence of various factors on water-bearing capacity of the Upper Sarmatian sediments was assessed, including the vulnerability of the fresh groundwater to the intrusion of brackish water from the Bug Estuary. The study also examined the feasibility of operating the aquifer under forced conditions, depending on the duration of emergency periods or military operations.

This article presents the visual and instrumental investigations, along with the necessary engineering and technical decisions, for restoring load-bearing structures of multi-storey residential buildings damaged by fire due to war. It is economically advisable to replace and strengthen 20% of the emergency floor slabs and 16% of the load-bearing walls to allow residents to return to their homes as soon as possible. The temperature during the fire was determined using specific samples of damaged materials, building structures, and equipment, which allowed for a more accurate assessment of the damage to brick walls and prefabricated reinforced concrete floor slabs. The possibility of further use of the building was also determined based on a survey and necessary measurements of its structures, including the determination of physical and mechanical characteristics (crack width, flexures, concrete strength, brick grade, and mortar grade). The prefabricated reinforced concrete round hollow floor slabs had delaminated along the ribs between the hollows, showing sagging. The bricks had changed colour and were destroyed to a depth of 120 mm (internal walls were destroyed to this depth on both sides). Considering the extent of the damage to the load-bearing structures, it is recommended that the inter-floor ceilings, load-bearing walls, and partitions be replaced and strengthened. For structures that do not require replacement or reinforcement, the justification for their continued safe operation has been completed in accordance with the construction standards and regulations in force in Ukraine.

Heart valve diseases are a prevalent cardiovascular pathology worldwide, affecting nearly 2.5% of the population. Degenerative aortic stenosis is the most common form of heart valve disease. The treatment options include surgical or transcatheter procedures. There are two main categories of valve prostheses available: mechanical heart valves constructed from synthetic materials and bioprosthetic heart valves made from natural biomaterials. The choice of valve type depends on various factors, including the underlying medical condition, suitability for anticoagulation, valve durability, and the patient’s age and preferences. Mechanical heart valves have the advantage of long-term durability. However, patients receiving mechanical implants are subjected to lifelong anticoagulation therapy with an increased risk of thromboembolism and bleeding. Natural biomaterials do not require long-term anticoagulation. However, they experience degenerative changes leading to structural valve deterioration (SVD) that may require reoperation. The purpose of this article is to review the role of natural biological materials used for aortic valve replacement or repair, assess their biomedical and clinical advantages and limitations, and analyze the direction and perspectives of future development.

На сьогодні, успішна корекція аортального стенозу проводиться з використанням як хірургічних, так і транскатетерних методик, які в свою чергу, не позбавлені різноманітних можливих ускладнень, одним з яких виступає гостре пошкодження нирок (ГПН). Метою роботи було оцінити частоту та визначити предиктори гострого пошкодження нирок в післяопераційному періоді у пацієнтів зі стенозом аортального клапана, залежно від застосованого методу хірургічного лікування. Методи. До ретроспективного відкритого дослідження було включено 126 пацієнтів зі стенозом аортального клапана, які отримували лікування протягом 2018-2022 р.р. в клініці ДУ «Інститут серця Міністерства охорони здоров’я України». Залежно від способу корекції аортального стенозу усі пацієнти були розділені на 2 групи – перша група, у якій корекція аортального стенозу проводилась шляхом транскатетерної імплантації аортального клапана (група TAVI, n = 47) та друга група, у якій корекція аортального стенозу проводилася за рахунок протезування аортального клапана біологічним протезом (група БіоПАК, n = 52). Порівняння досліджуваних груп проводилося щодо показників передопераційного, інтраопераційного та раннього післяопераційного періоду. ГПН визначалось на основі KDIGO критеріїв. Статистичну обробку отриманих результатів проведено на персональному комп’ютері за допомогою програми «MedCalc». Результати. Пацієнти, яким в подальшому проводили TAVI (Група 1), характеризувалися істотно старшим віком (р=0,002), на 10,4% достовірно нижчим рівнем гемоглобіну (р=0,001) та вищою оцінкою операційного ризику за EuroSCOREII (р

Pathologists can label pathologies differently, making it challenging to yield consistent assessments in the absence of one ground truth. To address this problem, we present a deep learning (DL) approach that draws on a cohort of experts, weighs each contribution, and is robust to noisy labels. We collected 100,495 annotations on 20,099 candidate amyloid beta neuropathologies (cerebral amyloid angiopathy (CAA), and cored and diffuse plaques) from three institutions, independently annotated by five experts. DL methods trained on a consensus-of-two strategy yielded 12.6-26% improvements by area under the precision recall curve (AUPRC) when compared to those that learned individualized annotations. This strategy surpassed individual-expert models, even when unfairly assessed on benchmarks favoring them. Moreover, ensembling over individual models was robust to hidden random annotators. In blind prospective tests of 52,555 subsequent expert-annotated images, the models labeled pathologies like their human counterparts (consensus model AUPRC = 0.74 cored; 0.69 CAA). This study demonstrates a means to combine multiple ground truths into a common-ground DL model that yields consistent diagnoses informed by multiple and potentially variable expert opinions.

The possibility of more dynamic development of economic, social, and political relations of Ukraine with the countries of Central and Eastern Europe, including with Poland and the countries of the European Union, is the basis of the idea of building railway lines of the European standard. Political and socio-economic circumstances in Ukraine require acceleration of the necessary organizational, technical, technological, and economic research. Implementation of such a large-scale project in Ukraine can be carried out with the participation of foreign partners. The partners' decision to participate in the project will be based on the results of the project analysis. It has been proven that not only the cost of design, search and construction and installation works for a certain infrastructure, but also the method of its calculation will be of great importance for making a reasoned decision. There is a well-founded need to consider the cost of performing works on the station infrastructure complex, both the port economy itself and railway stations in the port's catchment area. The preliminary assessment of the project should begin with its proper identification in the context of a broader investment program due to its impact on the economic, social, and political components of the European Union. There is a well-founded need to determine the geographical area on which the cargo flow can be generated. An essential element of the societal analysis is that the magnitude of the effect decreases significantly as the time interval decreases, and the elasticity results are much higher with national-level data than when using regional-level data. The mentioned provisions are important factors to consider in the project analysis of the introduction of the European track on the railway network of Ukraine in view of making a positive decision for Ukraine regarding the participation of foreign partners in this project and its financing.

Abstract The progression of human degenerative and hypoxic/ischemic diseases is accompanied by widespread cell death. One death process linking iron-catalyzed reactive species with lipid peroxidation is ferroptosis, which shows hallmarks of both programmed and necrotic death in vitro. While evidence of ferroptosis in neurodegenerative disease is indicated by iron accumulation and involvement of lipids, a stable marker for ferroptosis has not been identified. Its prevalence is thus undetermined in human pathophysiology, impeding recognition of disease areas and clinical investigations with candidate drugs. Here, we identified ferroptosis marker antigens by analyzing surface protein dynamics and discovered a single protein, Fatty Acid-Binding Protein 5 (FABP5), which was stabilized at the cell surface and specifically elevated in ferroptotic cell death. Ectopic expression and lipidomics assays demonstrated that FABP5 drives redistribution of redox-sensitive lipids and ferroptosis sensitivity in a positive-feedback loop, indicating a role as a functional biomarker. Notably, immunodetection of FABP5 in mouse stroke penumbra and in hypoxic postmortem patients was distinctly associated with hypoxically damaged neurons. Retrospective cell death characterized here by the novel ferroptosis biomarker FABP5 thus provides first evidence for a long-hypothesized intrinsic ferroptosis in hypoxia and inaugurates a means for pathological detection of ferroptosis in tissue.

This paper crowns efforts, made by its author, aiming in showing and proving that the current formula for calculation of the spectra of output signals at A/D converters requires a correcting factor in it. A number of partial results obtained and published in the last years are referred to here. They paved the way to a fully satisfactory and correct result; it is presented in this work. The corrected formula for spectrum calculation is derived using a description of the output signal of an A/D converter by means of the so-called Dirac comb, however not in a direct form, but with taking into account physical reality. In addition, the paper contains a number of interpretative remarks, comments, and explanations - clarifying those matters that have so far been omitted in analyses of the sampling process, despite the fact that they raised various types of doubts.

Supraventricular macro re-entry tachyarrhythmias occupy the leading places among all types of tachyarrhythmias. The most common in this category is typical atrial flutter (AFL). This heart rhythm disorder has a negative impact on the patients’ quality of life. Its complications can lead to disability and death due to possible thromboembolism. Therapeutic treatment is limited in effectiveness. The main method of intervention is catheter radiofrequency ablation (RFA). The standard approach of RFA of AFL is performed without the use of navigation systems under fluoroscopy guidance. However, this results in an increased radiation exposure to the patient and the medical personnel. Modern technologies in the field of invasive electrophysiology make it possible to create anatomical models of heart and reproduce the spread of electrical excitation. However, the routine use of additional navigation methods remains controversial. The aim. To compare the duration of RFA of typical AFL and radiation exposure with the use of anatomical and propagation mapping. Materials and methods. This study is based on the analysis of the treatment results obtained for 53 patients at the National Amosov Institute of Cardiovascular Surgery in the period from 2014 to 2023. Depending on imaging methods, the patients were divided into two groups. The first group included 27 patients with an anatomical mapping of the right atrium. The second group included 26 patients with propagation mapping. Results. In all the patients we have achieved a bidirectional conduction block through cavotricuspid isthmus. In the first group, the total duration of confirming the diagnosis and creating the anatomical model was 312 ± 26 seconds. The mean time to the moment of AFL termination and restoration of sinus rhythm was 230 ± 19 seconds. The average duration of the procedure was 41.5 ± 3.5 minutes, the average fluoroscopy time was 120 ± 10 seconds, the average dose area product (DAP) was 15 ± 1.3 Gy·cm2. In the second group, the average time for creating a 3D propagation model of right atrium and verifying the diagnosis was 748 ± 65 seconds. The average time from the first application to the termination of tachycardia was 227 ± 20 seconds. The average duration of the procedure was 55 ± 4.7 minutes, X-ray time was 93 ± 8 seconds, average DAP was 13 ± 1.1 Gy·cm2. The duration of the procedure in the second group was significantly longer (p = 0.03), however, the radiation exposure and DAP were not statistically different (p = 0.31) between the observation groups. Conclusions. The use of propagation mapping increases the time of the procedure by 24.5% and does not give a significant advantage in reducing the radiation exposure. The use of a navigation system during cavotricuspid isthmus RFA is recommended for concomitant radical treatment of complex supraventricular arrhythmias, such as atrial fibrillation.

The article presents innovative approaches to improving the risk management process in the context of developing a strategy for foreign economic activity of enterprise. To identify risks and choose the optimal strategy for foreign economic activity of enterprises (FEA), economic and mathematical modelling was used using the risk matrix and the criteria of Bayes, Laplace, Wald, Savage, Hurwitz, Hodge-Lehman. To approbate the results of the study, enterprises of the pharmaceutical industry were selected. According to the theory of games, in order to improve the risk management process, elements of the payment matrix have been applied, which characterize the profit of pharmaceutical enterprises in foreign economic activity. The use of the Hurwitz criterion, which is a criterion of pessimism-optimism, made it possible to choose the optimal strategy for the selected enterprises. The developed matrix of risks of foreign economic activity (strategic, operational, financial and external) for the selection of the optimal strategy of foreign economic activity through the use of economic and mathematical modelling should be used to determine the risks of the greatest impact at different stages of foreign economic activity using the theory of games. The presented matrix of risks of foreign economic activity is built for domestic enterprises of the pharmaceutical industry and is aimed at improving the process of risk management of foreign economic activity, which will enable enterprises of the pharmaceutical industry to predict risks at the early stages of activity and take into account in the general concept of the strategy of foreign economic activity of enterprises. The pharmaceutical industry of Ukraine was chosen for research because it is the most popular in modern conditions, and, according to the results of the analytical review, very high-risk. That is why the use of economic and mathematical modelling for risk calculation allows to optimize the economic behaviour of domestic pharmaceutical enterprises, while providing a reliable basis for making sound strategic decisions in the process of risk management in the context of developing a strategy for foreign economic activity. The risk management process, consisting of 7 stages and 18 steps, has been improved, and innovative tools have been proposed that facilitate the implementation of risk management in the enterprise in the process of developing a foreign trade strategy. The use of economic and mathematical modelling in risk forecasting and the formation of a foreign economic activity strategy will help enterprise managers to significantly increase management efficiency, reduce risks at the stage of planning foreign economic activity. The article improves the risk management process, which consists of 7 stages and 18 steps, and offers innovative tools that facilitate the implementation of risk management in the enterprise in the process of developing a foreign trade strategy. The use of economic and mathematical modelling in risk forecasting and the formation of a foreign economic activity strategy will help enterprise managers to significantly increase management efficiency, reduce risks at the stage of planning foreign economic activity.

Introduction. When making decisions under uncertainty, Savage's criterion is sometimes used, or the criterion of minimizing regrets [1]. Usually, in the literature, this decision situation is described in matrix language. In other words, both the number of decision alternatives and the number of states of nature are finite. Of particular interest are situations where the admissible domain of decision variants is a convex set, and the regrets with respect to each state of nature are expressed by convex functions. In this paper, we propose numerical methods for minimizing Savage's regret function, constructed based on the subgradient projection method with automatic step size adjustment [2, 3]. The convergence of these methods is demonstrated. Goal. In the article, the Savage function is defined as a function that expresses the maximum regret value, assumed to be a convex function with respect to the decision factors. This function measures the effectiveness of each decision relative to the set of states of nature. It is important to note that computing the values of these functions is complex because of the need to know the optimal solution for each state of nature. This difficulty is successfully overcome in the process of solving the problem of minimizing functions on convex sets, thanks to parallel solutions of m "internal" algorithms based on the number of states of nature, and one external algorithm, aimed at minimizing the Savage function. Each of the m+1 algorithms represent modifications of the subgradient projection method with a programmable way of adjusting the step size. Depending on the complexity of the constraints and the required precision, three theorems have been proven, confirming the convergence of the investigated methods. Results obtained. Constructive numerical algorithms have been developed for determining optimal decision alternatives under uncertainty, when the number of states of nature is finite, the admissible domain of control factors is convex and compact, and the Savage regret function serves as a decision criterion. The convergence of the corresponding algorithms to the set of optimal solutions has been proven, without knowing the exact values of the Savage function. Instead, estimates obtained from parallel runs of algorithms were used, aimed at determining optimal solutions for each state of nature. Conclusions. Uncertainty poses significant difficulties in designing and making decisions. Any decision made under uncertainty represents a certain risk or a certain regret. In cases where the number of states of nature is finite, the decision domain is convex, the target function with respect to each state of nature is convex, and the Savage regret function is adopted as the decision criterion, the decision-making problem can be successfully solved using numerical algorithms based on the generalized gradient method. The implementation of the algorithm is relatively simple, and the fields of application can be very diverse.

Social networks play an important role in the modern management of socio-cultural activities. Due to the widespread use of the Internet and the growing popularity of social media, these platforms have become an important tool for communication, information sharing, promotion of cultural events, and public engagement in cultural and socio-cultural initiatives. Social media provides an opportunity for organizations and cultural institutions to engage audiences through advertising campaigns, content marketing, viral marketing, and other methods. This allows you to draw attention to cultural events, exhibitions, performances, concerts and attract more spectators and participants. The aim of the article is to study the theoretical aspects of the use of social networks in the management of socio-cultural activities, as well as to analyze the practical experience of using social networks in the socio-cultural sphere and to develop recommendations for the optimal use of social media in the management of socio-cultural activities. The methods: analysis of literary sources, synthesis, system analysis, generalization, analysis of social network data, content analysis. It is found that social networks make it possible to preserve, popularize and talk eloquently about cultural heritage. Cultural organisations can share stories, photographs, videos and other materials that reveal national and cultural identity. It is researched that social networks facilitate interaction between cultural organizations, creators, and audiences. They create a fertile ground for cooperation and partnership, allowing organizations to co-host cultural events and engage the target audience. It is determined that social networks provide tools for tracking the efficiency of cultural events and analyzing audience data. It helps cultural organizations customize their programs and events to suit the interests and needs of their audiences. Social media has been found to allow for the creation of communities and forums where people can discuss topics related to culture, art, traditions, and more. This helps to keep the community active and share ideas. It is noted that the use of social networks by the management of socio-cultural activities also has its own challenges and risks. For example, the possibility of disseminating inaccurate information or negative reviews can negatively affect the reputation of cultural organizations. Therefore, it is important to be attentive and skillful in the management of social networks in order to achieve a positive impact on socio-cultural activities. Nowadays, social networks serve as a virtual social space for the interaction of individuals, resulting in the formation of a complex multi-level network of civic ties. Internet technologies form a new sphere of information interaction, which leads to the emergence of new types of social relations that unfold the social potential of citizens. Social networks become a favorable environment for civic activity, being a platform for communication between individuals and groups in the political, cultural, and social spheres.

Artykuł prezentuje wyniki badania zielonych pul w budżetach obywatelskich (dalej: BO), czyli wydzielonych środków przeznaczonych na sfinansowanie projektów o charakterze prośrodowiskowym. Tego typu rozwiązanie wprowadzono w N = 17 ośrodkach. Stanowiły one 6% miast powyżej 5 tys. mieszkańców, które zorganizowały BO w latach 2020–2022. Na projekty w ramach zielonych pul przeznaczano przeciętnie 10% środków w budżecie obywatelskim. W większości miast za projekty „zielone” uznano zadania polegające na tworzeniu i modernizacji terenów zieleni, jak również na pielęgnacji i sadzeniu roślinności. Rzadziej w ramach zielonych pul dopuszczano wnioski dotyczące małej retencji i gospodarki wodnej, organizacji wydarzeń czy opieki i ochrony nad zwierzętami. Wyniki analizy projektów wybranych do realizacji pokazują umiarkowaną efektywność badanego rozwiązania. Przeciętnie aż 62% środków przewidzianych na projekty „zielone” przeznaczono na roślinność. Skuteczność zielonych pul w poszczególnych miastach była jednak zróżnicowana. W niektórych ośrodkach do realizacji trafiały projekty „zielone” tylko z nazwy, które skupiały się raczej na rozwoju infrastruktury do rekreacji niż na poprawie stanu środowiska miejskiego. Poprawa funkcjonowania zielonych pul wymaga w pierwszej kolejności uszczelnienia lokalnych regulacji. Warto również rozważyć dopuszczenie szerszego katalogu zadań wpływających na adaptację miast do zmian klimatu, związanych np. ze zrównoważoną mobilnością czy transformacją energetyczną.

This year-long experimental study, conducted in Kitakyushu, Japan, evaluates the performance of a retrofitted Trombe wall designed to cultivate hydroponically grown basil plants, aiming to enhance its year-round usability. The results show that the addition of plants reduced overheating and moderated temperature fluctuations, but also led to a 30.2% decrease in absorption and a 49.4% decrease in dissipation efficiency compared to a traditional Trombe wall. Seasonal variations influenced the suitability of the space for cultivation, with optimal conditions occurring in spring and summer, while autumn and winter posed challenges due to extreme temperature fluctuations. The daily energy balance was largely unaffected by factors such as leaf transpiration, spontaneous evaporation, additional ventilation, or increased appliance use, as these were overshadowed by the primary thermal processes: solar gains and conductive losses. Although the modified TW still provided passive heating, its energy output was reduced to approximately 10,000 MJ annually, compared to the baseline 14,000 MJ. The study suggests that alternative designs, including increased thermal mass, improved ventilation and better plant selection and could improve both cultivation and energy efficiency. Ultimately, while the green TW is best suited for seasonal use, it offers ecological and social benefits, such as local food production and CO2 fixation, highlighting its potential for integration into sustainable architectural practices.

This paper reviews the ecosystem of GATE, an open-source Monte Carlo toolkit for medical physics. Based on the shoulders of Geant4, the principal modules (geometry, physics, scorers) are described with brief descriptions of some key concepts (Volume, Actors, Digitizer). The main source code repositories are detailed together with the automated compilation and tests processes (Continuous Integration). We then described how the OpenGATE collaboration managed the collaborative development of about one hundred developers during almost 20 years. The impact of GATE on medical physics and cancer research is then summarized, and examples of a few key applications are given. Finally, future development perspectives are indicated.

A multicriteria parametric optimization of nonlinear robust control with two degrees of freedom by a discrete-continuous plant has been developed to increase accuracy and reduce sensitivity to uncertain plant parameters. Such plants are mounted on a moving base, on which sensors for angles, angular velocities and angular accelerations are installed. To increase the accuracy of control, systems with two degrees of freedom, which include control with feedback and a closed-loop, and with direct connections and open-loop control of the setting and disturbing effects, are used. The multicriteria optimization of nonlinear robust control with two degrees of freedom by a discrete-continuous plant is reduced to the solution of the Hamilton-Jacobi-Isaacs equations. The robust control target vector is calculated as a solution of a zero-sum antagonistic vector game. The vector payoffs of this game are direct indexes performance vector presented in the system in different modes of its operation. The calculation of the vector payoffs of this game is related to the simulation of the synthesized nonlinear system for different operating modes of the system, input signals and values of the plant parameters. The solutions of this vector game are calculated on the basis of the system of Pareto-optimal solutions, taking into account the binary relations of preferences, on the basis of the stochastic metaheuristic of Archimedes optimization algorithm by several swarms. Thanks to the synthesis of nonlinear robust control with two degrees of freedom by a discrete-continuous object, it is shown that the use of synthesized controllers made it possible to increase the accuracy of control of an electromechanical system with distributed parameters of the mechanical part to reduce the time of transient processes by 1.5–2 times, reduce dispersion of errors by 1.3 times and reduce the sensitivity of the system to changes in the plant parameters in comparison with typical controllers used in existing systems. Further improvement of control accuracy is restrained by energy limitations of executive mechanisms and information limitations of measuring devices.

Neuroblastoma is the most common extracranial solid tumor in children. Amplification of the MYCN gene has been observed in approximately 20%–30% of tumors. It is strongly correlated with advanced-stage disease, rapid tumor progression, resistance to chemotherapy and poor outcomes independent of patient age and stage of advanced disease. MYCN amplification identifies high-risk patients. To assess neuroblastoma tumors with MYCN amplification we used paraffin-embedded tissue sections in 57 patients and intraoperative tumor imprints in 10 patients by fluorescence in situ hybridization (FISH). Positive results for MYCN amplification have been observed in twelve patients’ paraffin-embedded tissue sections and in three patients’ intraoperative tumor imprints, which represents 22.4% of all patients tested in the analysis. Fluorescence in situ hybridization is a highly sensitive and useful technique for detecting MYCN amplification on paraffin-embedded tissue sections of neuroblastoma tumors and intraoperative tumor imprints thus facilitating therapeutic decisions based on the presence or absence of this important biologic marker. The presence of structural changes, regardless of MYCN gene amplification status, influences the clinical behavior of neuroblastoma. High-Density SNP Arrays have emerged as the perfect tools for detecting these changes due to their exceptional accuracy, sensitivity and ability to analyze copy number and allele information. Consequently, they are proven to be highly valuable in the genomic diagnosis of immature neuroectodermal tumors.

Здійснено аналіз зірки Василя Пачовського «Розсипані перли» (1901) в аспекті відомого в українській поезії початку ХХ століття принципу не розташовувати поруч віршовані твори з однаковою формою. За цією ознакою стисло розглянуто композицію збірок любовних віршів попередників В. Пачовського – І. Франка та П. Карманського. У «Зівялому листі» І. Франка (1896) відсутнє розташування поруч поезій із тотожною формою. У збірці П. Карманського «З теки самовбивці» (1899) представлено низку прикладів розташування поруч творів з однаковою формою. Уведено поняття коефіцієнта збігів форми (відношення кількості повторів до кількості віршів збірки). У П. Карманського він становить 8,3 %. У збірці В. Пачовського загалом простежено тенденцію до розташування поруч творів різної форми. Розглянуто також пари віршів, у яких поет намагається урізноманітнити форму за допомогою строфіки (у творах «Вічно весни повертають…» і «Як зазуля весну чує…»), римування («Шумка» та «Орлиний лет»), уведення системного внутрішнього римування («Ой нависли мої мисли…», «І знов був я на забаві…»). Виділено шість випадків повторень форми в розташованих поруч поезіях. Коефіцієнт повторень форми у збірці – 5 %. Проаналізовано такі пари віршів: «На що їхав на забаву…» та «Ой як море стогне горе…», «Чому то як море филює…» та «Ганусю, схили ся на груди», «Ой нависли мої мисли…» та «І знов був я на забаві…», «Зонці Р. (Ой ти сьмішку, сьмій ся, сьмій!)» та «Як мине дитинний рай», «Дамен-Валс» та «Знов я бачу їх на муку…», «Моя Стефцю, моя зірко…» та «Найдені перли (В альбом Стефані М.)». Показано, що своєрідним «виправданням» збігів форми у «сусідніх» віршах збірки є їхня змістова єдність. Іноді одна поезія виступає продовженням іншої. Запропоновано вивчити у аспекті форми інші збірки поета.

El propósito de este trabajo fue valorar la percepción de igualdad de trato y discriminación en estudiantes de secundaria y examinar la valoración sobre los distintos factores metodológicos que influyen en la igualdad de trato y discriminación en EF. La muestra estuvo compuesta por 706 estudiantes (375 chicos y 331 chicas) con una edad media de 13.05 años (DE= .93). El instrumento de recogida de datos fue el Cuestionario de Percepción de Igualdad y Discriminación en EF y el análisis se realizó utilizando la prueba de normalidad Kolmogorov-Smirnov y la prueba de comparación de medias U de Mann-Whitney. Los resultados demuestran que existen diferencias significativas en la percepción de igualdad de trato con valores medios más altos en las chicas y en la percepción de discriminación con mayores puntajes en los chicos. A su vez, en los factores metodológicos relacionados con el lenguaje sexista y el feedback se presentan diferencias por sexo que corroboran la mayor percepción de discriminación en los chicos y de igualdad en las chicas. En conclusión, las formas de interacción utilizadas por el profesor tienen gran influencia sobre las percepciones del alumnado con relación a los estereotipos de género en el contexto de la EF.

The phenolic compounds in the leaves of 12 species of birch trees of the subgenera Neurobetula, Betulenta, and Betula were biochemically profiled using HPTLC. The duration of the vegetation period was found to be significantly related to the content of total phenols (r = 0.74) and flavonoids in leaves (r = 0.65). The correlations for Neurobetula plants were 0.86 and 0.91, respectively. The relationship between the duration of the growing season and the concentration of phenolic compounds in Betula plants was inverse (r =-0.84). A cluster analysis of phytochemical profiles revealed that the studied birch species form groups that coincide with the subgenera proposed by De Jong due to an affinity with the qualitative composition of phenolic compounds. A multiple correlation analysis confirmed the relationship between the qualitative composition of phenolic compounds and the morphological characteristics of the leaves. The results of phytochemical profiling revealed that the qualitative composition of polyphenols in the leaves of 12 birch species is quite specific, allowing the use of individual compounds as additional differential biochemical characters in identifying species and hybrids and studying their potential role in plant adaptation to habitat conditions. Key words: Betula, chemosystematics, introduction, flavonoids, tannins, 1. Introduction The plants of the genus Betula L. play an important role in the flora of the temperate forest zone, as well as the boreal and sub-arctic zones (Furlow [...]

The article is devoted to determining the specifics of war injuries among people of various ages living in the deoccupied Kyiv and Kharkiv regions of Ukraine. The purpose of the research is to determine the residents’ traumatic experience in the de-occupied territories of Ukraine caused by the Russian-Ukrainian war. The direct effects of PTSD concern intimate relationships such as marriage, social interactions, decreased productivity, and decreased resilience. This study shows that PTSD symptoms are more common for respondents over fifty years of age, who have deficit of social resources. It has been proven that the severity of PTSD symptoms in the residents of the deoccupied Kharkiv region is statistically significantly lower than the symptoms of the residents of the de-occupied Kyiv region, which is due to the longer occupation and more pronounced joy from liberation. Therefore, the appearance of PTSD symptoms in a more delayed period is likely.

In modern traction drive systems for electric rolling stock with induction traction motors, vector systems have found the greatest use as control systems. The reduction of losses in the traction drive system and, as a result, the reduction of electrical energy consumption depends on the accuracy of regulation of the controlled parameters. An analysis of studies devoted to the development of vector control systems has shown that taking into account the saturation of the magnetic system of an induction motor increases the accuracy of adjusting the controlled parameters. This study proposes a method for taking into account the saturation of the motor magnetic circuit through the main motor inductance, as a function of the magnetic circuit flux linkage. On the basis of the proposed method in the MATLab software environment, a simulation vector control system was performed with and without saturation. Comparison of the simulation results showed that neglect of saturation leads to an increase in the slip of the motor rotor by 0.0111 relative units and, as a result, to a decrease in the efficiency of the rotor by 1.02%.